Agitated Emergence

Synonym
Postanesthetic Excitement
Emergence Agitation
Emergence Delirium
Anesthesia Emergence Delirium
Emergence Excitement
Agitated Emergence

Excerpt	Reference
"Emergence delirium is typically assessed using the published and validated Pediatric Emergence Delirium (PAED) Scale."	( Archilla, CA; Bender, BM; Driscoll, JN; Hossain, MJ; Klim, CM; Mychaskiw, G; Wei, JL, 2017)
"Emergence delirium is defined as a cognitive disturbance during emergence from general anesthesia resulting in hallucinations, delusions and confusion manifested by agitation, restlessness, involuntary physical movement and extreme flailing in bed."	( Badeaux, J; Bonanno, LS; FitzSimons, J; Pierce, S, 2017)
"Postanesthesia emergence delirium is a motor agitation state complicating pediatric anesthesia."	( Anagnostopoulou, M; Kalliardou, E; Kouptsova, E; Malisiova, A; Mavri, M; Tsiotou, AG, 2018)
"Emergence delirium is a common complication of sevoflurane anesthesia in children."	( Choi, EK; Kim, WJ; Lee, S; Park, SJ, 2018)
"Emergence delirium is a common complication in children, especially in preschool children undergoing ophthalmic surgery."	( Chen, Q; Chi, W; Fang, Z; Gan, X; Lin, Y; Liu, Y; Liu, YZ; Shen, W; Wang, Q, 2018)
"Emergence agitation is common after nasal surgery under general anesthesia and may lead to serious consequences for the patient, including an increased risk of injury, pain, hemorrhage, and self-extubation."	( Choi, SS; Jo, JY; Jung, KW; Kim, HJ; Ku, S; Park, H; Park, SU, 2019)
"Emergence delirium is common following sevoflurane anesthesia, and can lead to patient harm and escalation of nursing care."	( Cusick, J; Lalwani, K; Martin, CS; Piper, L; Treggiari, MM; Yanez, ND, 2020)
"Emergence delirium is a well-known phenomenon that may be encountered after general anesthesia."	( Gutman, DA; Hassid, M; Jeanes, Z; Redding, AT; Romeo, D, 2020)
"Emergence delirium is a common complication in paediatric anaesthesia associated with significant morbidity."	( Aoyama, K; Englesakis, M; Levin, DN; Maynes, JT; Pechlivanoglou, P; Petre, MA, 2021)
"Pediatric emergence delirium is a psychomotor disorder occurring in the early postanesthetic stage."	( Han, X; Liu, X; Sun, X; Wang, Q, 2022)
"Emergence agitation is a common paediatric complication after inhalational anaesthesia."	( Lei, DX; She, YJ; Wang, LY; Wu, CJ; Wu, ZY; Zhao, Q, 2022)
"Emergence agitation is a common clinical condition in children."	( Afshari, A; Falcon, L; Garioud, ALB; Mondrup, F; Nielsen, BN, 2023)

Excerpt	Reference
"Although pediatric emergence delirium (ED) is common, preventive and therapeutic pharmacological treatment is the matter of an international controversial discussion and evidence on different options is partially vague."	( Baehner, T; Bode, C; Ellerkmann, RK; Erdfelder, F; Hoeft, A; Hoehne, C; Huett, C, 2017)
"Visual disturbance contributes to emergence delirium in preschool children undergoing ophthalmic surgery with sevoflurane, and prophylactic eyepatch treatment can reduce emergence delirium."	( Chen, Q; Chi, W; Fang, Z; Gan, X; Lin, Y; Liu, Y; Liu, YZ; Shen, W; Wang, Q, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	88 (34.65)	28.8240
2020's	166 (65.35)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	1	0
3,4-dihydroxyphenylacetic acid	low	1	0
melatonin	medium	8	3
nitrous oxide	medium	1	1
propionic acid	low	1	0
uric acid	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
homovanillic acid	low	1	0
hydroxyindoleacetic acid	low	1	0
acetaminophen	medium	2	1
baclofen	low	1	0
caffeine	medium	1	1
clonidine	medium	5	3
cyclobenzaprine	low	1	0
diphenhydramine	medium	1	1
droperidol	low	1	0
fentanyl	medium	13	9
flurbiprofen	medium	1	1
fp 83	medium	1	1
gabapentin	medium	3	2
haloperidol	low	1	0
lidocaine	medium	4	3
isoflurane	low	2	0
ketamine	medium	14	5
ketorolac	low	2	0
midazolam	medium	22	11
apnea	low	1	0
nefopam	medium	1	1
neostigmine	medium	1	1
propofol	medium	36	20
risperidone	low	1	0
sevoflurane	medium	67	42
succinylcholine	medium	1	1
tranexamic acid	low	1	0
physostigmine	low	1	0
phenylephrine	medium	1	1
mannitol	medium	2	1
pyridostigmine bromide	low	1	0
glycopyrrolate	low	1	0
hexafluoroisopropanol	medium	1	1
xenon	medium	3	2
magnesium sulfate	medium	6	2
tramadol	medium	3	2
sufentanil	medium	6	2
desflurane	medium	4	2
alfentanil	medium	4	3
remifentanil	medium	9	6
atropine	medium	1	1
ropivacaine	medium	2	1
esketamine	medium	2	2
ramelteon	medium	7	4
rocuronium	medium	1	1
tropisetron	low	1	0
etomidate	low	2	0
thiopental	low	1	0
dezocine	low	1	0
bilirubin	low	1	0
hydromorphone	medium	1	1
oxycodone	low	2	0
dexmedetomidine	medium	97	52
nalbuphine	medium	3	1
palonosetron	low	1	0
remimazolam	medium	9	3
ribose	low	1	0
lurasidone hydrochloride	low	1	0
scopolamine hydrobromide	low	1	0
oligonucleotides	low	1	0
suvorexant	low	1	0
quetiapine fumarate	low	1	0
piperidines	medium	4	3
interleukin-8	low	1	0
minocycline	medium	1	1
humulin s	low	1	0
olanzapine	low	1	0

Protein Targets (696)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	15	0	0	15
USP1 protein, partial	9	0	0	9
TDP1 protein	14	0	0	14
vitamin D3 receptor isoform VDRA	6	0	0	6
importin subunit beta-1 isoform 1	1	0	0	1
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
geminin	16	0	0	16
DNA polymerase kappa isoform 1	3	0	0	3
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	3	2	5
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	6	0	0	6
endonuclease IV	3	0	0	3
RGS12	1	0	0	1
phosphopantetheinyl transferase	6	0	0	6
NFKB1 protein, partial	6	0	0	6
GLS protein	12	0	0	12
Microtubule-associated protein tau	7	0	0	7
Thrombopoietin	4	0	0	4
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	2	0	0	2
apical membrane antigen 1, AMA1	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
thyroid stimulating hormone receptor	13	0	0	13
hypothetical protein, conserved	2	0	0	2
regulator of G-protein signaling 4	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
Bloom syndrome protein isoform 1	7	0	0	7
lysosomal alpha-glucosidase preproprotein	3	0	0	3
peripheral myelin protein 22 isoform 1	5	0	0	5
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	11	0	0	11
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	4	0	0	4
M-phase phosphoprotein 8	6	0	0	6
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	1	1
muscarinic acetylcholine receptor M1	14	0	0	14
lamin isoform A-delta10	21	0	0	21
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	7	1	8
Zinc finger protein mex-5	0	0	1	1
ATP-dependent phosphofructokinase	7	0	0	7
RAR-related orphan receptor gamma	9	0	0	9
ATAD5 protein, partial	8	0	0	8
Smad3	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	3	0	0	3
EWS/FLI fusion protein	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	6	0	0	6
estrogen-related nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	19	0	0	19
peroxisome proliferator activated receptor gamma	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	9	0	0	9
peripheral myelin protein 22	9	0	0	9
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	5	1	16
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Bile salt export pump	0	27	0	27
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	2	0	2
Cytochrome P450 3A4	0	7	0	8
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2C9	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	10	5	1	16
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	10	5	1	16
Gamma-aminobutyric acid receptor subunit gamma-2	10	5	2	17
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	10	5	1	16
Gamma-aminobutyric acid receptor subunit alpha-3	10	5	1	16
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	2	0	2
Prostaglandin G/H synthase 1	0	5	0	5
Carbonic anhydrase 6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	10	5	1	16
Gamma-aminobutyric acid receptor subunit alpha-2	10	5	1	16
Gamma-aminobutyric acid receptor subunit alpha-4	10	5	1	16
Gamma-aminobutyric acid receptor subunit gamma-3	10	5	1	16
Gamma-aminobutyric acid receptor subunit alpha-6	10	5	1	16
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase 7	0	2	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	10	5	2	17
Gamma-aminobutyric acid receptor subunit beta-3	10	5	1	16
Gamma-aminobutyric acid receptor subunit beta-2	10	5	2	17
Carbonic anhydrase 9	0	2	0	2
GABA theta subunit	10	5	1	16
Canalicular multispecific organic anion transporter 1	0	14	0	14
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	10	5	1	16
Carbonic anhydrase 14	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
toxin B	0	0	0	1
ATP-dependent translocase ABCB1	0	6	0	9
Mu-type opioid receptor	0	11	1	12
Kappa-type opioid receptor	0	5	0	5
Mu-type opioid receptor	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	7	0	7
arylsulfatase A	6	0	0	6
D(1A) dopamine receptor	7	0	0	7
neuropeptide S receptor isoform A	2	0	0	2
GLI family zinc finger 3	10	0	0	10
AR protein	17	0	0	17
glucocorticoid receptor [Homo sapiens]	8	0	0	8
pregnane X nuclear receptor	10	0	0	10
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	11	0	13
5-hydroxytryptamine receptor 4	0	16	0	16
Muscarinic acetylcholine receptor M2	0	11	1	15
Muscarinic acetylcholine receptor M4	0	13	1	16
Muscarinic acetylcholine receptor M1	0	7	1	10
Muscarinic acetylcholine receptor M3	0	6	1	9
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M5	0	15	1	18
Muscarinic acetylcholine receptor M2	0	8	2	13
Muscarinic acetylcholine receptor M1	0	11	2	16
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	12	1	15
Alpha-1D adrenergic receptor	0	13	1	14
5-hydroxytryptamine receptor 2C	0	14	0	14
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	6	0	0	9
5-hydroxytryptamine receptor 7	0	4	0	4
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
67.9K protein	1	0	0	1
activating transcription factor 6	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	4	0	0	4
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
thyroid hormone receptor beta isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
nuclear receptor ROR-gamma isoform 1	4	0	0	4
lethal factor (plasmid)	4	0	0	4
Potassium channel subfamily K member 2	0	2	1	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	6	0	6
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	7	0	8
Adenosine receptor A1	0	4	0	5
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	1	4
Adenosine receptor A1	0	1	1	4
Adenosine receptor A2a	0	2	1	5
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	2	0	2
Chain A, Ferritin light chain	3	0	0	3
acetylcholinesterase	7	0	0	7
cytochrome P450 2D6	11	0	0	11
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	3	3
cytochrome P450 2D6 isoform 1	9	0	0	9
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	5	0	0	5
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	2	2
Solute carrier family 22 member 3	0	3	0	4
5-hydroxytryptamine receptor 1A	0	7	3	10
Alpha-2A adrenergic receptor	0	12	3	15
Alpha-1B adrenergic receptor	0	9	0	9
Alpha-2B adrenergic receptor	0	11	1	12
Alpha-1A adrenergic receptor	0	1	3	4
Alpha-2C adrenergic receptor	0	12	3	15
D	0	7	0	7
D(3) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 1A	0	10	0	10
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	7	0	7
Alpha-2A adrenergic receptor	0	8	0	8
Alpha-1D adrenergic receptor	0	9	0	9
D(1B) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1B	0	8	0	8
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	6	0	6
Delta-type opioid receptor	0	4	0	4
Alpha-1A adrenergic receptor	0	6	2	8
Alpha-1B adrenergic receptor	0	5	2	7
Alpha-1A adrenergic receptor	0	10	1	11
Spike glycoprotein	12	0	0	12
D(2) dopamine receptor	0	10	0	10
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	4	0	4
Nischarin	0	2	0	2
15-lipoxygenase, partial	2	0	0	2
Fumarate hydratase	4	0	0	4
PPM1D protein	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
polyprotein	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Interferon beta	4	0	0	4
D(1A) dopamine receptor	2	1	0	3
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Ataxin-2	4	0	0	4
Mu-type opioid receptor	0	9	8	17
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
huntingtin isoform 2	1	0	0	1
Cellular tumor antigen p53	10	0	0	10
Aldo-keto reductase family 1 member B1	0	6	0	6
Angiotensin-converting enzyme	0	8	0	8
5-hydroxytryptamine receptor 2A	0	11	0	11
Histamine H1 receptor	0	2	0	3
Histamine H1 receptor	0	11	1	12
5-hydroxytryptamine receptor 2B	0	14	0	14
Histamine N-methyltransferase	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
Sodium channel protein type 5 subunit alpha	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	7	0	7
Calcium release-activated calcium channel protein 1	0	1	0	1
Protein orai-2	0	1	0	1
Protein orai-3	0	1	0	1
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
glp-1 receptor, partial	5	0	0	5
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
mitogen-activated protein kinase 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
D(2) dopamine receptor	0	10	1	13
D(1A) dopamine receptor	0	8	0	9
D(3) dopamine receptor	0	9	1	12
N-acetyltransferase Eis	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	5	0	5
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	0	4
Glutamate receptor ionotropic, NMDA 3B	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	4	0	4
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	2	4
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	2	4
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	2	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	2	3
Transporter	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
D(4) dopamine receptor	0	6	1	9
Delta-type opioid receptor	0	6	0	6
Kappa-type opioid receptor	0	5	0	5
Delta-type opioid receptor	0	6	1	7
Kappa-type opioid receptor	0	6	3	9
Mu-type opioid receptor	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	5	0	5
caspase 7, apoptosis-related cysteine protease	5	0	0	5
estrogen receptor 2 (ER beta)	2	0	0	2
caspase-3	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	3	1	4
Amyloid-beta precursor protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	4
Aldo-keto reductase family 1 member C4	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Solute carrier family 22 member 6	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
G	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
survival motor neuron protein isoform d	5	0	0	5
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
nonstructural protein 1	2	0	0	2
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	7	0	7
Beta-2 adrenergic receptor	0	3	0	3
Integrin alpha-4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	7	0	7
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	4	0	4
D(2) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	3
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 3A	0	3	0	3
Histamine H2 receptor	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	7	0	7
Histamine H1 receptor	0	3	0	3
Sodium-dependent serotonin transporter	0	7	0	7
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	0	4
5-hydroxytryptamine receptor 2A	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	3	0	3
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 6	0	4	0	5
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	3	0	3
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
ClpP	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
alpha-galactosidase	2	0	0	2
IDH1	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	5	0	5
Neuronal acetylcholine receptor subunit alpha-7	0	2	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	5	0	6
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cholinesterase	0	4	0	5
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
Caspase-1	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
interleukin 8	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	3	1	4
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	3	1	4
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Histamine H3 receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Translocator protein	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
5-hydroxytryptamine receptor 3E	0	3	2	7
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
5-hydroxytryptamine receptor 3B	0	4	3	9
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	6	3	11
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
5-hydroxytryptamine receptor 3D	0	3	2	7
5-hydroxytryptamine receptor 3C	0	3	2	7
Solute carrier family 22 member 2	0	2	0	2
Integrin beta-3	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-4	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	1	2
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	3	1	4
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
dopamine D1 receptor	1	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Free fatty acid receptor 2	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Histone H2A.x	1	0	0	1
heat shock protein beta-1	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Orexin receptor type 1	0	2	0	2
Orexin receptor type 2	0	2	0	2
Orexin receptor type 1	0	1	0	1
Orexin receptor type 2	0	1	0	1
Substance-K receptor	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (254)

Protein Targets (696)

Agitated Emergence

Synonyms(6)

Research Excerpts

Overview

Treatment

Research

Studies (254)

Drugs Studied (89)

Protein Targets (696)