ketamine has been researched along with Pulmonary Hypertension in 10 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The safety of ketamine in children with pulmonary hypertension has been debated because of conflicting results of prior studies in which changes in mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) have been widely variable." | 7.83 | Hemodynamic response to ketamine in children with pulmonary hypertension. ( Cardwell, KA; Darst, JR; Fagan, TE; Friesen, RH; Ivy, DD; Miyamoto, SD; Nichols, CS; Pan, Z; Twite, MD; Wilson, N, 2016) |
| "The use of a combination of dexmedetomidine and ketamine to provide procedural sedation in a 12-year old boy with a diagnosis of idopathic pulmonary hypertension and a behavioral disorder, undergoing diagnostic cardiac catheterization, is presented." | 7.75 | Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension. ( Felix, DE; Munro, HM; Nykanen, DG, 2009) |
| "In the presence of sevoflurane, ketamine did not increase pulmonary vascular resistance in spontaneously breathing children with severe pulmonary hypertension." | 7.74 | Ketamine does not increase pulmonary vascular resistance in children with pulmonary hypertension undergoing sevoflurane anesthesia and spontaneous ventilation. ( Boltz, MG; Chu, LF; Feinstein, JA; Hammer, GB; Kamra, K; Perry, SB; Philip, BM; Ramamoorthy, C; Terwey, H; Williams, GD, 2007) |
| "To study the effects of ketamine on structurally remodeled pulmonary arteries from rats with hypoxic pulmonary hypertension (PH) and the effects of ketamine on endothelium-dependent and -independent relaxation, rats were exposed to hypobaric hypoxia (air at 380 mm Hg for 10 days)." | 7.69 | Vasodilatory effects of ketamine on pulmonary arteries in rats with chronic hypoxic pulmonary hypertension. ( Maruyama, J; Maruyama, K; Miyasaka, K; Muneyuki, M; Yokochi, A, 1995) |
| "Ketamine is a drug often used for procedural sedation or as adjunct agent for general sedation in children with congenital heart disease." | 6.58 | Hemodynamic effects of ketamine in children with congenital heart disease and/or pulmonary hypertension. ( Flores, S; Gray, SB; Loomba, RS, 2018) |
| "Ketamine appears to be a safe anesthetic option for children with PAH." | 5.36 | Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010) |
| "The safety of ketamine in children with pulmonary hypertension has been debated because of conflicting results of prior studies in which changes in mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) have been widely variable." | 3.83 | Hemodynamic response to ketamine in children with pulmonary hypertension. ( Cardwell, KA; Darst, JR; Fagan, TE; Friesen, RH; Ivy, DD; Miyamoto, SD; Nichols, CS; Pan, Z; Twite, MD; Wilson, N, 2016) |
| "Monocrotaline (MCT) is commonly used to experimentally induce pulmonary hypertension (PH), which might lead to chronic heart failure." | 3.76 | Analysis of heart rate variability in a rat model of induced pulmonary hypertension. ( Bernardes, J; Brandão-Nogueira, A; Gonçalves, H; Henriques-Coelho, T; Leite-Moreira, A; Rocha, AP, 2010) |
| "The use of a combination of dexmedetomidine and ketamine to provide procedural sedation in a 12-year old boy with a diagnosis of idopathic pulmonary hypertension and a behavioral disorder, undergoing diagnostic cardiac catheterization, is presented." | 3.75 | Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension. ( Felix, DE; Munro, HM; Nykanen, DG, 2009) |
| "In the presence of sevoflurane, ketamine did not increase pulmonary vascular resistance in spontaneously breathing children with severe pulmonary hypertension." | 3.74 | Ketamine does not increase pulmonary vascular resistance in children with pulmonary hypertension undergoing sevoflurane anesthesia and spontaneous ventilation. ( Boltz, MG; Chu, LF; Feinstein, JA; Hammer, GB; Kamra, K; Perry, SB; Philip, BM; Ramamoorthy, C; Terwey, H; Williams, GD, 2007) |
| "To study the effects of ketamine on structurally remodeled pulmonary arteries from rats with hypoxic pulmonary hypertension (PH) and the effects of ketamine on endothelium-dependent and -independent relaxation, rats were exposed to hypobaric hypoxia (air at 380 mm Hg for 10 days)." | 3.69 | Vasodilatory effects of ketamine on pulmonary arteries in rats with chronic hypoxic pulmonary hypertension. ( Maruyama, J; Maruyama, K; Miyasaka, K; Muneyuki, M; Yokochi, A, 1995) |
| "Ketamine is a drug often used for procedural sedation or as adjunct agent for general sedation in children with congenital heart disease." | 2.58 | Hemodynamic effects of ketamine in children with congenital heart disease and/or pulmonary hypertension. ( Flores, S; Gray, SB; Loomba, RS, 2018) |
| "Ketamine appears to be a safe anesthetic option for children with PAH." | 1.36 | Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loomba, RS | 1 |
| Gray, SB | 1 |
| Flores, S | 1 |
| Williams, GD | 3 |
| Friesen, RH | 3 |
| Twite, MD | 1 |
| Nichols, CS | 1 |
| Cardwell, KA | 1 |
| Pan, Z | 1 |
| Darst, JR | 1 |
| Wilson, N | 1 |
| Fagan, TE | 1 |
| Miyamoto, SD | 1 |
| Ivy, DD | 1 |
| Munro, HM | 1 |
| Felix, DE | 1 |
| Nykanen, DG | 1 |
| Maan, H | 1 |
| Ramamoorthy, C | 2 |
| Kamra, K | 2 |
| Bratton, SL | 1 |
| Bair, E | 1 |
| Kuan, CC | 1 |
| Hammer, GB | 2 |
| Feinstein, JA | 2 |
| Gonçalves, H | 1 |
| Henriques-Coelho, T | 1 |
| Bernardes, J | 1 |
| Rocha, AP | 1 |
| Brandão-Nogueira, A | 1 |
| Leite-Moreira, A | 1 |
| Philip, BM | 1 |
| Chu, LF | 1 |
| Boltz, MG | 1 |
| Terwey, H | 1 |
| Perry, SB | 1 |
| Maruyama, K | 1 |
| Maruyama, J | 1 |
| Yokochi, A | 1 |
| Muneyuki, M | 1 |
| Miyasaka, K | 1 |
| Alswang, M | 1 |
| Tarnow, J | 1 |
| Hess, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure During Congenital Pulmonary Stenosis Balloon Dilatation[NCT05582213] | 40 participants (Actual) | Interventional | 2022-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ketamine and Pulmonary Hypertension
| Article | Year |
|---|---|
Hemodynamic effects of ketamine in children with congenital heart disease and/or pulmonary hypertension.
Topics: Anesthesia; Anesthetics, Dissociative; Cardiac Surgical Procedures; Child; Heart Defects, Congenital | 2018 |
Administration of ketamine to children with pulmonary hypertension is safe: pro-con debate: Pro Argument.
Topics: Humans; Hypertension, Pulmonary; Ketamine; Lung; Perioperative Care | 2012 |
8 other studies available for ketamine and Pulmonary Hypertension
| Article | Year |
|---|---|
Hemodynamic response to ketamine in children with pulmonary hypertension.
Topics: Adolescent; Analgesics; Arterial Pressure; Cardiac Output; Child; Child, Preschool; Cohort Studies; | 2016 |
Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension.
Topics: Anesthetics, Dissociative; Cardiac Catheterization; Child; Dexmedetomidine; Drug Therapy, Combinatio | 2009 |
Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine.
Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Blood Pressure; Cardiac Surgical Procedu | 2010 |
Analysis of heart rate variability in a rat model of induced pulmonary hypertension.
Topics: Animals; Disease Models, Animal; Electrocardiography; Entropy; Heart Rate; Hypertension, Pulmonary; | 2010 |
Ketamine does not increase pulmonary vascular resistance in children with pulmonary hypertension undergoing sevoflurane anesthesia and spontaneous ventilation.
Topics: Adolescent; Anesthesia, Inhalation; Cardiac Catheterization; Child; Child, Preschool; Drug Synergism | 2007 |
Vasodilatory effects of ketamine on pulmonary arteries in rats with chronic hypoxic pulmonary hypertension.
Topics: Acetylcholine; Animals; Arginine; Dinoprost; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; | 1995 |
Changes in carbon dioxide tension and oxygen saturation during deep sedation for paediatric cardiac catheterization.
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Blood Pressure; Carbon | 1996 |
[Pulmonary hypertension and pulmonary edema caused by intravenous ketamine (author's transl)].
Topics: Anesthesia, General; Coronary Disease; Fentanyl; Humans; Hypertension, Pulmonary; Hypoxia; Injection | 1978 |