ketamine has been researched along with Bradyarrhythmia in 20 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Tracings were analyzed for evidence of apnea, periodic breathing and/or bradycardia by a pulmonologist unaware of the anesthetic technique utilized." | 9.06 | Postoperative apnea in former preterm infants: prospective comparison of spinal and general anesthesia. ( Broadman, LM; Fink, R; Hannallah, RS; Rice, LJ; Ruttimann, UE; Welborn, LG, 1990) |
| " In a controlled study, we evaluated the effects of yohimbine, an antagonist of xylazine, on the anesthesia induced by this anesthetic combination in cats." | 7.67 | Effect of yohimbine on xylazine-ketamine anesthesia in cats. ( Hsu, WH; Lu, ZX, 1984) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 6.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "Medetomidine-based premedication protocols led to various bradyarrhythmias." | 5.69 | Sedative effects and changes in cardiac rhythm with intravenous premedication of medetomidine, butorphanol and ketamine in dogs. ( Eberspächer-Schweda, E; Schöndorfer, B; Vogl, C, 2023) |
| " NMDA receptor antagonists versus no treatment, placebo, oral sweet solution, or non-pharmacological intervention One RCT evaluated using oral ketamine (10 mg/kg body weight) versus sugar syrup (66." | 5.41 | Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023) |
| "We evaluated the use of continuous infusion of ketamine to reduce intraoperative remifentanil side effects, such as bradycardia and hypotension, and to improve postoperative analgesia from balanced anesthesia with remifentanil." | 5.13 | [Balanced anesthesia with continuous ketamine reduces adverse effects of remifentanil]. ( Onaka, M; Yamamoto, H, 2008) |
| " Tracings were analyzed for evidence of apnea, periodic breathing and/or bradycardia by a pulmonologist unaware of the anesthetic technique utilized." | 5.06 | Postoperative apnea in former preterm infants: prospective comparison of spinal and general anesthesia. ( Broadman, LM; Fink, R; Hannallah, RS; Rice, LJ; Ruttimann, UE; Welborn, LG, 1990) |
| "The objective of this study was to compare the development of clinically significant hypotension or bradycardia (ie, negative hemodynamic event) between critically ill adults receiving sedation with ketamine and either propofol or dexmedetomidine." | 4.12 | Hemodynamic Effects of Ketamine Compared With Propofol or Dexmedetomidine as Continuous ICU Sedation. ( Atchley, E; Bauer, A; Benken, S; Meyer, R; Pulver, M; Tesoro, E, 2022) |
| " The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)." | 3.73 | Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006) |
| " In a controlled study, we evaluated the effects of yohimbine, an antagonist of xylazine, on the anesthesia induced by this anesthetic combination in cats." | 3.67 | Effect of yohimbine on xylazine-ketamine anesthesia in cats. ( Hsu, WH; Lu, ZX, 1984) |
| " Propofol-based sedation is simple, easy to use, and effective, but is not without cardiovascular and respiratory adverse effects." | 2.82 | A randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP. ( Goyal, R; Hasnain, S; Mittal, S; Shreevastava, S, 2016) |
| "Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect." | 2.77 | Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012) |
| "Cardiac arrhythmias were observed in 21 (53·8%) dogs." | 1.40 | Management and complications of anaesthesia during balloon valvuloplasty for pulmonic stenosis in dogs: 39 cases (2000 to 2012). ( Monteiro-Steagall, BP; Ramos, RV; Steagall, PV, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 6 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atchley, E | 1 |
| Tesoro, E | 1 |
| Meyer, R | 1 |
| Bauer, A | 1 |
| Pulver, M | 1 |
| Benken, S | 1 |
| Kamohara, H | 1 |
| Kamohara, T | 1 |
| Hikasa, Y | 1 |
| Schöndorfer, B | 1 |
| Vogl, C | 1 |
| Eberspächer-Schweda, E | 1 |
| Persad, E | 1 |
| Pizarro, AB | 1 |
| Bruschettini, M | 1 |
| Krenz, JR | 1 |
| Medeiros, K | 1 |
| Lupez, K | 1 |
| Emerling, AD | 1 |
| Fisher, J | 1 |
| Walrath, B | 1 |
| Drew, B | 1 |
| Tsukamoto, A | 1 |
| Niino, N | 1 |
| Sakamoto, M | 1 |
| Ohtani, R | 1 |
| Inomata, T | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Ramos, RV | 1 |
| Monteiro-Steagall, BP | 1 |
| Steagall, PV | 1 |
| Espahbodi, E | 1 |
| Sanatkar, M | 1 |
| Sadrossadat, H | 1 |
| Darabi Vafsi, ME | 1 |
| Azarshahin, M | 1 |
| Shoroughi, M | 1 |
| Goyal, R | 1 |
| Hasnain, S | 1 |
| Mittal, S | 1 |
| Shreevastava, S | 1 |
| Onaka, M | 1 |
| Yamamoto, H | 1 |
| Krimins, RA | 1 |
| Ko, JC | 1 |
| Weil, AB | 1 |
| Payton, ME | 1 |
| Constable, PD | 1 |
| Ayatollahi, V | 1 |
| Behdad, S | 1 |
| Kargar, S | 1 |
| Yavari, T | 1 |
| Sharma, AK | 1 |
| Kumar, N | 1 |
| Dimri, U | 1 |
| Hoque, M | 1 |
| Maiti, SK | 1 |
| Gupta, OP | 1 |
| Shahi, A | 1 |
| Mensour, M | 1 |
| Pineau, R | 1 |
| Sahai, V | 1 |
| Michaud, J | 1 |
| Errando, CL | 1 |
| Murcia, M | 1 |
| Gimeno, A | 1 |
| Herrera, R | 1 |
| Hsu, WH | 1 |
| Lu, ZX | 1 |
| Tripathi, M | 1 |
| Saxena, GC | 1 |
| Welborn, LG | 1 |
| Rice, LJ | 1 |
| Hannallah, RS | 1 |
| Broadman, LM | 1 |
| Ruttimann, UE | 1 |
| Fink, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| A Randomized, Controlled Trial to Compare the Efficacy and Safety Profile of a Remimazolam-alfentanil Combination With a Propofol-alfentanil Combination for ERCP[NCT04658173] | 1,000 participants (Anticipated) | Interventional | 2020-12-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for ketamine and Bradyarrhythmia
| Article | Year |
|---|---|
Non-opioid analgesics for procedural pain in neonates.
Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei | 2023 |
8 trials available for ketamine and Bradyarrhythmia
| Article | Year |
|---|---|
Sedative effects and changes in cardiac rhythm with intravenous premedication of medetomidine, butorphanol and ketamine in dogs.
Topics: Animals; Bradycardia; Butorphanol; Dog Diseases; Dogs; Heart Rate; Hypnotics and Sedatives; Ketamine | 2023 |
Ketamine or atropine: which one better prevents oculocardiac reflex during eye surgery? A prospective randomized clinical trial.
Topics: Anesthesia, General; Arrhythmias, Cardiac; Atropine; Bradycardia; Child; Child, Preschool; Humans; K | 2015 |
A randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP.
Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recover | 2016 |
[Balanced anesthesia with continuous ketamine reduces adverse effects of remifentanil].
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Bradycar | 2008 |
Hemodynamic effects in dogs after intramuscular administration of a combination of dexmedetomidine-butorphanol-tiletamine-zolazepam or dexmedetomidine-butorphanol-ketamine.
Topics: Analgesia; Animals; Blood Pressure; Bradycardia; Butorphanol; Cardiac Output; Cross-Over Studies; De | 2012 |
Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.
Topics: Adult; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Ephedrine; Female; Humans; Hypote | 2012 |
Low dose ketamine: an ideal supplementary anaesthesia for spinal block.
Topics: Anesthesia, Intravenous; Bradycardia; Diazepam; Double-Blind Method; Female; Humans; Hypotension; Ke | 1992 |
Postoperative apnea in former preterm infants: prospective comparison of spinal and general anesthesia.
Topics: Anesthesia, General; Anesthesia, Spinal; Apnea; Bradycardia; Hernia, Inguinal; Humans; Infant, Newbo | 1990 |
11 other studies available for ketamine and Bradyarrhythmia
| Article | Year |
|---|---|
Hemodynamic Effects of Ketamine Compared With Propofol or Dexmedetomidine as Continuous ICU Sedation.
Topics: Adult; Bradycardia; Dexmedetomidine; Hemodynamics; Humans; Hypnotics and Sedatives; Hypotension; Int | 2022 |
Reversal effects of atipamezole, flumazenil, and 4-aminopyridine on bradycardia and increases in blood pressures induced by medetomidine, midazolam, and ketamine in isoflurane-anesthetized cats.
Topics: 4-Aminopyridine; Animals; Blood Pressure; Bradycardia; Cat Diseases; Cats; Flumazenil; Heart Rate; I | 2022 |
Retrospective evaluation of ketamine versus droperidol on time to restraint removal in agitated emergency department patients.
Topics: Bradycardia; Droperidol; Emergency Service, Hospital; Humans; Ketamine; Psychomotor Agitation; Respi | 2023 |
Rapid Ketamine Infusion at an Analgesic Dose Resulting in Transient Hypotension and Bradycardia in the Emergency Department.
Topics: Analgesics; Bradycardia; Emergency Service, Hospital; Humans; Hypotension; Infusions, Intravenous; K | 2020 |
The validity of anesthetic protocols for the surgical procedure of castration in rats.
Topics: Administration, Inhalation; Anesthesia; Anesthetics; Animal Experimentation; Animals; Bradycardia; B | 2018 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Management and complications of anaesthesia during balloon valvuloplasty for pulmonic stenosis in dogs: 39 cases (2000 to 2012).
Topics: Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Arrhythmias, Card | 2014 |
Romifidine-ketamine anaesthesia in atropine and triflupromazine pre-medicated buffalo calves.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics, Dissociative; Animals; Atropine; Bradycardia; Buffal | 2004 |
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana | 2006 |
[Anesthesia in a patient with Angelman syndrome].
Topics: Adolescent; Androstanols; Anesthesia, Inhalation; Anesthesia, Intravenous; Angelman Syndrome; Bradyc | 2007 |
Effect of yohimbine on xylazine-ketamine anesthesia in cats.
Topics: Anesthesia; Animals; Bradycardia; Cat Diseases; Cats; Female; Heart Block; Heart Rate; Ketamine; Mal | 1984 |