ketamine and Cholera Infantum studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

Excerpt	Relevance	Reference
" The most common treatment-emergent adverse events associated with ketamine/esketamine are dissociation, anxiety, nausea, increased blood pressure, and headache."	6.72	Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. ( Cao, B; Ceban, F; Chau, EH; Gill, H; Ho, RC; Kratiuk, K; Kumar, A; Lee, JG; Lee, Y; Lin, K; Lipsitz, O; Lui, LMW; Mansur, RB; McIntyre, RS; Nasri, F; Rodrigues, NB; Rosenblat, JD; Subramaniapillai, M; Swainson, J, 2021)
"Citrullinemia has been identified as a simple, sensitive and suitable biomarker for radiation-induced injury associated with gastrointestinal ARS (GI-ARS)."	5.43	Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. ( Ascah, A; Authier, S; Bujold, K; Donini, O; Hartman, D; Hauer-Jensen, M; Hendrickson, HP; Naraghi, H; Pouliot, M; Pugsley, MK; Rumage, A; Sebastian, M; Stamatopoulos, J; Wong, K, 2016)
"Ketamine did not prevent LPS induced gastrointestinal ileus, nor did it improve gastric emptying."	3.73	Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation. ( Gonzalez, EA; Mercer, DW; Moore, FA; Moore-Olufemi, SD; Suliburk, JW; Weisbrodt, N, 2005)
" The most common treatment-emergent adverse events associated with ketamine/esketamine are dissociation, anxiety, nausea, increased blood pressure, and headache."	2.72	Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. ( Cao, B; Ceban, F; Chau, EH; Gill, H; Ho, RC; Kratiuk, K; Kumar, A; Lee, JG; Lee, Y; Lin, K; Lipsitz, O; Lui, LMW; Mansur, RB; McIntyre, RS; Nasri, F; Rodrigues, NB; Rosenblat, JD; Subramaniapillai, M; Swainson, J, 2021)
"Ketamine is an N-methyl-d-aspartate receptor antagonist, a dissociative anaesthetic agent and a treatment option for major depression, treatment-resistant depression, and bipolar disorder."	2.58	Management of complications of ketamine abuse: 10 years' experience in Hong Kong. ( Hong, YL; Lai, PT; Ng, CF; Tam, YH; Wong, JH; Yee, CH, 2018)
"Ketamine is a dissociative anesthetic and substance of abuse."	2.50	Ketamine: an update on its abuse. ( Anderson, PD; Bokor, G, 2014)
"Citrullinemia has been identified as a simple, sensitive and suitable biomarker for radiation-induced injury associated with gastrointestinal ARS (GI-ARS)."	1.43	Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. ( Ascah, A; Authier, S; Bujold, K; Donini, O; Hartman, D; Hauer-Jensen, M; Hendrickson, HP; Naraghi, H; Pouliot, M; Pugsley, MK; Rumage, A; Sebastian, M; Stamatopoulos, J; Wong, K, 2016)

Research

Studies (16)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants With Any Type of Airway Obstruction

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (31.25)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (25.00)	29.6817
2010's	6 (37.50)	24.3611
2020's	1 (6.25)	2.80

Authors	Studies
Ceban, F	1
Rosenblat, JD	1
Kratiuk, K	1
Lee, Y	1
Rodrigues, NB	1
Gill, H	1
Subramaniapillai, M	1
Nasri, F	1
Lui, LMW	1
Lipsitz, O	1
Kumar, A	1
Lee, JG	1
Chau, EH	1
Cao, B	1
Lin, K	1
Ho, RC	1
Mansur, RB	1
Swainson, J	1
McIntyre, RS	1
Liu, SYW	1
Ng, SKK	1
Tam, YH	2
Yee, SCH	1
Lai, FPT	1
Hong, CYL	1
Chiu, PWY	1
Ng, EKW	1
Ng, CF	2
Fallon, MT	1
Wilcock, A	1
Kelly, CA	1
Paul, J	1
Lewsley, LA	1
Norrie, J	1
Laird, BJA	1
Hong, YL	1
Yee, CH	1
Wong, JH	1
Lai, PT	1
Bokor, G	1
Anderson, PD	1
Bujold, K	1
Hauer-Jensen, M	1
Donini, O	1
Rumage, A	1
Hartman, D	1
Hendrickson, HP	1
Stamatopoulos, J	1
Naraghi, H	1
Pouliot, M	1
Ascah, A	1
Sebastian, M	1
Pugsley, MK	1
Wong, K	1
Authier, S	1
Pambianco, DJ	1
Adam, F	1
Medhi, B	1
Kaur, S	1
Sarangi, SC	1
Suliburk, JW	2
Gonzalez, EA	1
Moore-Olufemi, SD	1
Weisbrodt, N	1
Moore, FA	1
Mercer, DW	2
Shemesh, E	1
Bat, L	1
Yahav, J	1
Niv, Y	1
Jonas, A	1
Rozen, P	1
Stoianov, E	1
Koeva, T	1
Danev, S	1
Goranova, M	1
Kunovski, M	1
Mendenhall, MK	1
Ahlgren, EW	1
Feins, NR	1
Briciu, RM	1
Filipescu, Z	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Pilot Study of the Use of Oral Ketamine for Treatment of Vaso-Occlusive Pain in Adolescents and Young Adults[NCT05378555]	Phase 3	10 participants (Anticipated)	Interventional	2023-05-01	Recruiting
Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy[NCT02643979]	Phase 4	22 participants (Actual)	Interventional	2016-01-01	Terminated (stopped due to Lack of Enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The Anesthesiologist caring for the patient during the upper endoscopy made note of any obstructive events defined on a scale ranging from the patient audibly snoring (obstructing) to the patient obstructing and requiring assistance such as a chin lift or jaw thrust to relieve the obstruction and continue to move air adequately. (NCT02643979)
Timeframe: Day 1

Number of Participants With Emergence Delirium

Intervention	Participants (Count of Participants)
Ketofol: Ketamine and Propofol	4
Propofol Only	3

Number of participants with emergence delirium measured from the procedure end until time of discharge. (NCT02643979)
Timeframe: Day 1

Number of Participants With Gagging Reaction

Intervention	Participants (Count of Participants)
Ketofol: Ketamine and Propofol	0
Propofol Only	0

"Number of participants with gagging or vomit-like reaction on endoscopic insertion" (NCT02643979)
Timeframe: Day 1

Number of Participants With Post-operative Nausea and/or Vomiting

Time to Recovery

Intervention	Participants (Count of Participants)
Ketofol: Ketamine and Propofol	2
Propofol Only	1

Intervention	Participants (Count of Participants)
Ketofol: Ketamine and Propofol	0
Propofol Only	0

Monitored via the electronic medical record system as the time between the anesthesia end time and when the patient was safe for discharge from the hospital. (NCT02643979)
Timeframe: Day 1

Total Dose of Propofol Used During the Procedure

Intervention	minutes (Mean)
Ketofol: Ketamine and Propofol	21
Propofol Only	25

Propofol doses are logged in the computerized Compurecord system used in the operating room. Patients involved in the study had their total Propofol dose required quantified and compared between groups who received Ketamine and groups who did not. (NCT02643979)
Timeframe: Day 1

Total Sedation Required to Allow Initiation of Procedure

Intervention	mg/kg (Mean)
Ketofol: Ketamine and Propofol	9.09
Propofol Only	39

Using the computerized record system, the amount of Propofol a patient required to allow for the procedure to start quantified and compared between groups. (NCT02643979)
Timeframe: Day 1

Article	Year
Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. CNS drugs, 2021, Volume: 35, Issue:9 Topics: Administration, Intranasal; Administration, Intravenous; Antidepressive Agents; Anxiety; Disease Man	2021
Management of complications of ketamine abuse: 10 years' experience in Hong Kong. Hong Kong medical journal = Xianggang yi xue za zhi, 2018, Volume: 24, Issue:2 Topics: Gastrointestinal Diseases; Humans; Ketamine; Substance-Related Disorders; Urologic Diseases	2018
Ketamine: an update on its abuse. Journal of pharmacy practice, 2014, Volume: 27, Issue:6 Topics: Gastrointestinal Diseases; Humans; Ketamine; Mental Disorders; Substance-Related Disorders; Urologic	2014
Future directions in endoscopic sedation. Gastrointestinal endoscopy clinics of North America, 2008, Volume: 18, Issue:4 Topics: Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Conscious Sedati	2008
[Patient-controlled analgesia. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care]. Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2 Topics: Analgesia, Patient-Controlled; Antiemetics; Droperidol; Drug Administration Routes; Drug Synergism;	2009
Pediatric surgery. Current concepts. Pediatric clinics of North America, 1974, Volume: 21, Issue:2 Topics: Abdomen; Ambulatory Care; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Burns; Child; Ch	1974

Article	Year
Oral Ketamine vs Placebo in Patients With Cancer-Related Neuropathic Pain: A Randomized Clinical Trial. JAMA oncology, 2018, 06-01, Volume: 4, Issue:6 Topics: Aged; Analgesics; Antineoplastic Agents; Anxiety; Cancer Pain; Cognition Disorders; Depression; Doub	2018
[Clinical study of combined anesthesia with ketamine and diazepam]. Khirurgiia, 1978, Volume: 31, Issue:6 Topics: Adolescent; Adult; Aged; Analgesia; Anesthesia, Intravenous; Blood Pressure; Clinical Trials as Topi	1978

Article	Year
Clinical pattern and prevalence of upper gastrointestinal toxicity in patients abusing ketamine. Journal of digestive diseases, 2017, Volume: 18, Issue:9 Topics: Abdominal Pain; Administration, Inhalation; Adolescent; Adult; Analgesics; Anemia; Case-Control Stud	2017
Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. Radiation research, 2016, Volume: 186, Issue:1 Topics: Acepromazine; Acute Radiation Syndrome; Animals; Biomarkers; Citrulline; Citrullinemia; Eating; Gast	2016
Effect of low dose of ketamine in sepsis with gastrointestinal complication. The Journal of trauma, 2010, Volume: 69, Issue:1 Topics: Anesthetics, Dissociative; Animals; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Ketam	2010
Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation. The Journal of surgical research, 2005, Volume: 127, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Body Fluids; Gastric Emptying; Gastric Mucosa;	2005
Ketamine attenuates early lipopolysaccharide-induced gastric dysfunction: role of stress-inducible phosphoproteins. The Journal of trauma, 2007, Volume: 62, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Anti-Inflammatory Agents; Body	2007
Ketamine anesthesia for pediatric gastrointestinal procedures. Israel journal of medical sciences, 1982, Volume: 18, Issue:7 Topics: Adolescent; Anesthesia, General; Atropine; Child; Child, Preschool; Diazepam; Endoscopy; Gastrointes	1982
Anesthetic considerations in surgery for gastrointestinal disease. The Surgical clinics of North America, 1979, Volume: 59, Issue:5 Topics: Aged; Anesthetics; Drug Interactions; Enflurane; Female; Gastrointestinal Diseases; Halothane; Human	1979
[Dissociated anesthesia]. Chirurgia, 1974, Volume: 23, Issue:6 Topics: Adult; Aged; Anesthesia, General; Anesthetics, Dissociative; Female; Gastrointestinal Diseases; Huma	1974

ketamine and Cholera Infantum