ketamine and Itching
ketamine has been researched along with Itching in 17 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging." | 7.88 | NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation. ( Huang, Y; Li, S; Qin, J; Shen, L; Wang, W, 2018) |
| "Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging." | 3.88 | NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation. ( Huang, Y; Li, S; Qin, J; Shen, L; Wang, W, 2018) |
| "The ketamine group was administered a ketamine bolus and infusion during surgery." | 2.71 | Intraoperative intravenous ketamine in combination with epidural analgesia: postoperative analgesia after renal surgery. ( Karaman, H; Kararmaz, A; Kaya, S; Ozyilmaz, MA; Turhanoglu, S, 2003) |
| "IVPCA ketamine in combination with morphine provides superior postsurgical pain relief at lower dosage and with fewer side effects than morphine alone." | 2.68 | Comparison of morphine and morphine with ketamine for postoperative analgesia. ( Colclough, GW; Javery, KB; Steger, HG; Ussery, TW, 1996) |
| "This will promote the research and treatment of pruritus and depression." | 1.48 | The behavioral study on the interactive aggravation between pruritus and depression. ( Bai, Y; Feng, YP; Li, H; Wang, XD; Yang, G, 2018) |
Research
Studies (17)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kwatra, SG | 1 |
| Kambala, A | 1 |
| Cornman, H | 1 |
| Reddy, SV | 1 |
| Cohen, SP | 1 |
| Ferreira, S | 1 |
| Azevedo, A | 1 |
| Velho, GC | 1 |
| Sanches, M | 1 |
| Selores, M | 1 |
| Lee, HG | 1 |
| Grossman, SK | 1 |
| Valdes-Rodriguez, R | 1 |
| Berenato, F | 1 |
| Korbutov, J | 1 |
| Chan, YH | 1 |
| Lavery, MJ | 1 |
| Yosipovitch, G | 2 |
| Jaller, JA | 1 |
| Shen, L | 1 |
| Wang, W | 1 |
| Li, S | 1 |
| Qin, J | 1 |
| Huang, Y | 1 |
| Wang, XD | 1 |
| Yang, G | 1 |
| Bai, Y | 1 |
| Feng, YP | 1 |
| Li, H | 1 |
| Poterucha, TJ | 2 |
| Murphy, SL | 2 |
| Davis, MD | 3 |
| Sandroni, P | 2 |
| Rho, RH | 2 |
| Warndahl, RA | 2 |
| Weiss, WT | 2 |
| Griffin, JR | 1 |
| Cardis, MA | 1 |
| Pasieka, HB | 1 |
| Adam, F | 1 |
| Horvath, G | 1 |
| Joo, G | 1 |
| Kekesi, G | 1 |
| Farkas, I | 1 |
| Tuboly, G | 1 |
| Petrovszki, Z | 1 |
| Benedek, G | 1 |
| Kararmaz, A | 1 |
| Kaya, S | 1 |
| Karaman, H | 1 |
| Turhanoglu, S | 1 |
| Ozyilmaz, MA | 1 |
| Javery, KB | 1 |
| Ussery, TW | 1 |
| Steger, HG | 1 |
| Colclough, GW | 1 |
| Chia, YY | 2 |
| Liu, K | 2 |
| Liu, YC | 1 |
| Chang, HC | 1 |
| Wong, CS | 1 |
| Fischer, M | 1 |
| Steinborn, A | 1 |
| Tan, PH | 1 |
| Kuo, MC | 1 |
| Kao, PF | 1 |
Clinical Trials (7)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?[NCT00486902] | 188 participants (Actual) | Interventional | 2006-07-31 | Completed | |||
| The Use of Ketamine as Rescue Analgesia in the Recovery Room Following Opioid Administration. A Double-blind Randomised Trial in Postoperative Patients.[NCT00163969] | Phase 4 | 40 participants | Interventional | 2002-04-30 | Completed | ||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.[NCT06010056] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery[NCT06021717] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
| Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT02363270] | 48 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study[NCT01835262] | Phase 4 | 90 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Mechanical Thresholds (Mechanical Detection and Pain).
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Thermal Threshold Detection (Warmth and Heat Pain)
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
Cumulative Hydrocodone/Acetaminophen for Supplemental Analgesia to Treat Breakthrough Pain
Cumulative hydrocodone/acetaminophen for supplemental analgesia to treat breakthrough pain for 72 hours following cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | tablets (Median) |
|---|---|
| Ketamine | 10 |
| Placebo | 9 |
Disturbing Dreams
Number of subject reporting disturbing dreams at 72 hours post cesarean delivery (NCT00486902)
Timeframe: 72 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 0 |
| Placebo | 0 |
Number of Subjects Requiring Supplemental Analgesia in the First 24 Hours Following Cesarean Delivery
Request for oral hydrocodone/acetaminophen for pain not controlled by around the clock non-steroidal antiflammatory drugs in the first 24 hours following cesarean delivery. (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 64 |
| Placebo | 66 |
Pain Score (0-10) at 2 Weeks Following Cesarean Delivery
Numeric rating for pain score (0 to 10) reported at 2 weeks following cesarean delivery. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 2 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 2 |
| Placebo | 2.6 |
Postoperative Nausea
Number of subjects reporting nausea in first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 27 |
| Placebo | 30 |
Postoperative Vomiting
Number of subjects that vomited in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 13 |
| Placebo | 13 |
Postperative Pruritus
Number of subjects with pruritus in the first 24 hours following cesarean delivery (NCT00486902)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Ketamine | 12 |
| Placebo | 19 |
Verbal Pain Scores (0 to 10) at First Analgesia Request
Numeric rating of pain scores (NRS) scale (0 to 10) at time of supplemental analgesia request. Zero is no pain and 10 is worst pain imaginable. (NCT00486902)
Timeframe: 24 hours
| Intervention | Scores on a scale (Median) |
|---|---|
| Ketamine | 3 |
| Placebo | 4 |
Overall Rate of Feeling Unreality
Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) (NCT02363270)
Timeframe: 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| IV Push Group | 22 |
| IV Drip Group | 13 |
Numeric Rating Scale of Pain
"We will compare efficacy as a difference between 2 groups in pain score at 30 minutes post-analgesic administration. The primary outcome is the difference between 2 groups in pain score at 30 minutes.~Pain will be measured via Numeric rating scale from 0 to 10 with 0 being no pain, 5 being moderate pain, and 10 being severe pain" (NCT01835262)
Timeframe: 30 minutes
| Intervention | Units on a scale (Mean) |
|---|---|
| Morphine | 3.93 |
| Ketamine Group | 4.07 |
Reviews
1 review available for ketamine and Itching
| Article | Year |
|---|---|
[Patient-controlled analgesia. Pain and Locoregional Anesthesia Committee and the Standards Committee of the French Society of Anesthesia and Intensive Care].
Topics: Analgesia, Patient-Controlled; Antiemetics; Droperidol; Drug Administration Routes; Drug Synergism; | 2009 |
Trials
4 trials available for ketamine and Itching
| Article | Year |
|---|---|
Intraoperative intravenous ketamine in combination with epidural analgesia: postoperative analgesia after renal surgery.
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthesia, General; Anesthetics, Dissociative; Anes | 2003 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Comparison of morphine and morphine with ketamine for postoperative analgesia.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Diskectomy; Double-Blind Metho | 1996 |
Adding ketamine in a multimodal patient-controlled epidural regimen reduces postoperative pain and analgesic consumption.
Topics: Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Dissociative; A | 1998 |
Patient-controlled epidural analgesia with morphine or morphine plus ketamine for post-operative pain relief.
Topics: Abdomen; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Arousal | 1999 |
Other Studies
12 other studies available for ketamine and Itching
| Article | Year |
|---|---|
Ketamine Infusions for Treatment-Resistant Neuropathic Pruritus.
Topics: Cervical Vertebrae; Humans; Ketamine; Pruritus | 2023 |
Epidermolysis Bullosa Pruriginosa successfully treated with concomitant topical and systemic agents.
Topics: Administration, Topical; Amitriptyline; Analgesics; Drug Therapy, Combination; Epidermolysis Bullosa | 2020 |
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability.
Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy, | 2017 |
Successful Treatment of Epidermal Nevus-associated Pruritus with Topical Ketamine-Amitriptyline-Lidocaine.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Antipruritics; Drug Combinations; Forehead; Hu | 2018 |
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation.
Topics: Analgesia; Animals; Butadienes; Extracellular Signal-Regulated MAP Kinases; Injections, Spinal; Keta | 2018 |
The behavioral study on the interactive aggravation between pruritus and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chloroquine; Depression; Depressive Disorder; Dise | 2018 |
Topical amitriptyline-ketamine for the treatment of brachioradial pruritus.
Topics: Administration, Cutaneous; Adult; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Forearm; Huma | 2013 |
Topical amitriptyline combined with topical ketamine for the management of recalcitrant localized pruritus: a retrospective pilot study.
Topics: Administration, Topical; Adult; Aged; Amitriptyline; Chronic Disease; Female; Follow-Up Studies; Hum | 2013 |
Amitriptyline/Ketamine as therapy for neuropathic pruritus and pain secondary to herpes zoster.
Topics: Administration, Cutaneous; Amitriptyline; Analgesics; Drug Combinations; Gels; Herpes Zoster; Humans | 2015 |
Safety of Topical Neuromodulators for the Treatment of Pruritus.
Topics: Administration, Topical; Aged, 80 and over; Amitriptyline; Analgesics, Non-Narcotic; Dose-Response R | 2016 |
Inhibition of itch-related responses at spinal level in rats.
Topics: 5-Methoxytryptamine; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Drug Interaction | 2011 |
Therapy-resistant erythrodermia-related pruritus: effective treatment with ketamine hydrochloride.
Topics: Dermatitis, Exfoliative; Excitatory Amino Acid Antagonists; Humans; Ketamine; Middle Aged; Pruritus | 1999 |