ketamine has been researched along with Aging in 49 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "The ketamine CRI rate was 19." | 5.56 | Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques. ( Biscola, NP; Christe, KL; Colman, RJ; Havton, LA, 2020) |
| " Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 5.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
| "While the effects of varenicline across the different behavioral tasks were modest, these data suggest that varenicline may have potential as a repurposed drug for disorders of cognition associated with aging (e." | 3.83 | Effects of the nicotinic agonist varenicline on the performance of tasks of cognition in aged and middle-aged rhesus and pigtail monkeys. ( Callahan, PM; Plagenhoef, M; Terry, AV, 2016) |
| "The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses." | 3.81 | Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats. ( Burns, P; Giroux, MC; Hélie, P; Vachon, P, 2015) |
| "An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
| "An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
| "As part of an ophthalmic and anthropometric survey of two free-breeding rhesus monkey (Macaca mulatta) populations, intraocular pressure (IOP) of 114 animals was measured under ketamine catalepsia with the use of a floating-tip pneumatonometer." | 3.66 | Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two free-breeding colonies. ( Bito, LZ; DeRousseau, CJ; Merritt, SQ, 1979) |
| "Additionally, trisomy 21 (P = 0." | 2.76 | Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study. ( Bodian, C; Chakravarti, S; Hollinger, I; Hossain, S; Kin, N; Krol, M; Mittnacht, AJ; Nguyen, K; Srivastava, S; Weismann, C, 2011) |
| "The ketamine beta-t1/2s were not dose related." | 2.68 | A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies. ( Domino, EF; Fekete, G; Kovacs, V; Stetson, P; Zsigmond, EK, 1997) |
| " Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 1.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
| "Ketamine is a NMDA receptor (NMDAR) antagonist used in pediatric anesthesia." | 1.42 | Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice. ( Bénard, M; Brasse-Lagnel, C; Dupré, N; Gonzalez, BJ; Henry, VJ; Jégou, S; Lecointre, M; Leroux-Nicollet, I; Marret, S; Ramdani, Y; Roy, V; Vézier, C, 2015) |
| " The rate constant of elimination of both drugs was greatly decreased and the elimination half-life was significantly greater in old compared with young rats." | 1.39 | Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats. ( Beaudry, F; Carrier, D; Castel, A; Vachon, P; Veilleux-Lemieux, D, 2013) |
| "Body weight was decreased on PNDs 8-18 in PCP-treated pups and PNDs 8-10 in KET-treated pups." | 1.35 | Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. ( Boctor, SY; Ferguson, SA; Wang, C, 2008) |
| "Ketamine hydrochloride was administered intravenously to unpremedicated and xylazine-treated calves." | 1.27 | The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride. ( Waterman, AE, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (20.41) | 18.7374 |
| 1990's | 9 (18.37) | 18.2507 |
| 2000's | 11 (22.45) | 29.6817 |
| 2010's | 16 (32.65) | 24.3611 |
| 2020's | 3 (6.12) | 2.80 |
| Authors | Studies |
|---|---|
| Mielke, N | 1 |
| Johnson, S | 1 |
| Bahl, A | 1 |
| Fadladdin, YAJ | 1 |
| Xue, M | 1 |
| Zhang, X | 8 |
| Chen, J | 3 |
| Liu, F | 1 |
| Xu, J | 3 |
| Xie, J | 1 |
| Yang, Y | 4 |
| Yu, W | 1 |
| Qiu, H | 1 |
| Xue, J | 2 |
| Jiang, J | 3 |
| Liu, Y | 10 |
| Shallom, SJ | 1 |
| Zelazny, AM | 1 |
| Giri, AR | 1 |
| Kaur, N | 1 |
| Yarrarapu, SNS | 1 |
| Rottman Pietrzak, KA | 1 |
| Santos, C | 1 |
| Lowman, PE | 1 |
| Niaz, S | 1 |
| Franco, PM | 1 |
| Sanghavi, DK | 1 |
| Zhu, D | 1 |
| Liang, R | 1 |
| Li, Z | 4 |
| Cheng, L | 1 |
| Ren, J | 1 |
| Guo, Y | 2 |
| Wang, M | 2 |
| Chai, H | 1 |
| Niu, Q | 1 |
| Yang, S | 2 |
| Bai, J | 2 |
| Yu, H | 2 |
| Zhang, H | 2 |
| Qin, X | 1 |
| Sahrakorpi, N | 1 |
| Engberg, E | 1 |
| Stach-Lempinen, B | 1 |
| Tammelin, TH | 1 |
| Kulmala, J | 1 |
| Roine, RP | 1 |
| Koivusalo, SB | 1 |
| Cheng, W | 1 |
| Pang, H | 1 |
| Campen, MJ | 1 |
| Zhang, J | 6 |
| Li, Y | 5 |
| Gao, J | 1 |
| Ren, D | 1 |
| Ji, X | 1 |
| Rothman, N | 1 |
| Lan, Q | 1 |
| Zheng, Y | 2 |
| Leng, S | 1 |
| Hu, Z | 2 |
| Tang, J | 4 |
| Dong, Q | 2 |
| Song, N | 1 |
| Qin, N | 1 |
| Chen, C | 1 |
| Sun, X | 2 |
| Easton, J | 1 |
| Mulder, H | 1 |
| Plyler, E | 1 |
| Neale, G | 1 |
| Walker, E | 1 |
| Li, Q | 1 |
| Ma, X | 2 |
| Chen, X | 4 |
| Huang, IC | 1 |
| Yasui, Y | 1 |
| Ness, KK | 1 |
| Hudson, MM | 1 |
| Robison, LL | 1 |
| Wang, Z | 3 |
| Subota, A | 1 |
| Spotswood, N | 1 |
| Roach, M | 1 |
| Goodarzi, Z | 1 |
| Holroyd-Leduc, J | 1 |
| Park, EA | 1 |
| Graves, SA | 1 |
| Menda, Y | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 7 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 6 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 4 |
| Chen, L | 2 |
| Yang, X | 2 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 3 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
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| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
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| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
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| Vilchez-Tschischke, JP | 1 |
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| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
| Nafady, MM | 1 |
| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
| Nery, FC | 1 |
| de Carvalho, PA | 1 |
| Prudente, DO | 1 |
| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
| Paiva, R | 1 |
| Marchiori, PER | 1 |
| Lu, M | 2 |
| An, Z | 1 |
| Li, J | 8 |
| Du, S | 1 |
| Zhou, H | 1 |
| Cui, J | 1 |
| Wu, W | 1 |
| Song, J | 1 |
| Lian, Q | 1 |
| Uddin Ahmad, Z | 1 |
| Gang, DD | 1 |
| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
| Zappi, ME | 1 |
| Yang, TWW | 1 |
| Johari, Y | 1 |
| Burton, PR | 1 |
| Earnest, A | 1 |
| Shaw, K | 1 |
| Hare, JL | 1 |
| Brown, WA | 1 |
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| Choi, GH | 1 |
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| Lim, YS | 1 |
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| Gasbarrini, A | 1 |
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| Ryabov, AD | 1 |
| Collins, TJ | 1 |
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| Doddipatla, S | 1 |
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| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
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| Yu, X | 3 |
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| Hanke, I | 1 |
| Ganschow, S | 1 |
| Catalan, G | 1 |
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| Assefa, MK | 1 |
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| Hayton, TW | 1 |
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| Shi, J | 2 |
| Carreno, J | 1 |
| Kloner, RA | 1 |
| Pickersgill, NA | 1 |
| Vetter, JM | 1 |
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| Cope, SJ | 1 |
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| Venkatesh, R | 1 |
| Giardina, JD | 1 |
| Saad, NES | 1 |
| Bhayani, SB | 1 |
| Figenshau, RS | 1 |
| Eriksson, J | 1 |
| Landfeldt, E | 1 |
| Ireland, S | 1 |
| Jackson, C | 1 |
| Wyatt, E | 1 |
| Gaudig, M | 1 |
| Stancill, JS | 1 |
| Happ, JT | 1 |
| Broniowska, KA | 1 |
| Hogg, N | 1 |
| Corbett, JA | 1 |
| Tang, LF | 1 |
| Bi, YL | 1 |
| Fan, Y | 2 |
| Sun, YB | 1 |
| Wang, AL | 1 |
| Xiao, BH | 1 |
| Wang, LF | 1 |
| Qiu, SW | 1 |
| Guo, SW | 1 |
| Wáng, YXJ | 1 |
| Sun, J | 2 |
| Chu, S | 1 |
| Pan, Q | 1 |
| Li, D | 2 |
| Zheng, S | 2 |
| Ma, L | 1 |
| Wang, L | 3 |
| Hu, T | 1 |
| Wang, F | 1 |
| Han, Z | 1 |
| Yin, Z | 1 |
| Ge, X | 1 |
| Xie, K | 1 |
| Lei, P | 1 |
| Dias-Santagata, D | 1 |
| Lennerz, JK | 1 |
| Sadow, PM | 1 |
| Frazier, RP | 1 |
| Govinda Raju, S | 1 |
| Henry, D | 1 |
| Chung, T | 1 |
| Kherani, J | 1 |
| Rothenberg, SM | 1 |
| Wirth, LJ | 1 |
| Marti, CN | 1 |
| Choi, NG | 1 |
| Bae, SJ | 1 |
| Ni, L | 1 |
| Luo, X | 1 |
| Dai, T | 1 |
| Lee, R | 1 |
| Fleischer, AS | 1 |
| Wemhoff, AP | 1 |
| Ford, CR | 1 |
| Kleppinger, EL | 1 |
| Helms, K | 1 |
| Bush, AA | 1 |
| Luna-Abanto, J | 1 |
| García Ruiz, L | 1 |
| Laura Martinez, J | 1 |
| Álvarez Larraondo, M | 1 |
| Villoslada Terrones, V | 1 |
| Dukic, L | 1 |
| Maric, N | 1 |
| Simundic, AM | 1 |
| Chogtu, B | 1 |
| Ommurugan, B | 1 |
| Thomson, SR | 1 |
| Kalthur, SG | 1 |
| Benidir, M | 1 |
| El Massoudi, S | 1 |
| El Ghadraoui, L | 1 |
| Lazraq, A | 1 |
| Benjelloun, M | 1 |
| Errachidi, F | 1 |
| Cassar, M | 1 |
| Law, AD | 1 |
| Chow, ES | 1 |
| Giebultowicz, JM | 1 |
| Kretzschmar, D | 1 |
| Salonurmi, T | 1 |
| Nabil, H | 1 |
| Ronkainen, J | 1 |
| Hyötyläinen, T | 1 |
| Hautajärvi, H | 1 |
| Savolainen, MJ | 1 |
| Tolonen, A | 1 |
| Orešič, M | 1 |
| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
| Hukkanen, J | 1 |
| Zhu, N | 1 |
| Du, Q | 1 |
| Hao, P | 1 |
| Cao, X | 1 |
| Li, CX | 1 |
| Zhao, S | 1 |
| Luo, XM | 1 |
| Feng, JX | 1 |
| Gonzalez-Cotto, M | 1 |
| Guo, L | 2 |
| Karwan, M | 1 |
| Sen, SK | 1 |
| Barb, J | 1 |
| Collado, CJ | 1 |
| Elloumi, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults[NCT03901612] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-05 | Withdrawn (stopped due to covid and surgeon left) | ||
| Bilateral Erector Spinae Plane (ESP) Catheters Versus Single Shot ESP Block for Open Heart Surgery in Infants[NCT03593642] | 40 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for ketamine and Aging
| Article | Year |
|---|---|
Topics: Adult; Aging; Aluminum; Alzheimer Disease; Animals; Anti-Bacterial Agents; Artemisia annua; Body Mas | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Clinically important drug interactions with intravenous anaesthetics in older patients.
Topics: Aged; Aging; Anesthetics, Intravenous; Barbiturates; Benzodiazepines; Drug Interactions; Etomidate; | 2003 |
Newborn anaesthesia: pharmacological considerations.
Topics: Aging; Anesthesia; Anesthesia, Inhalation; Cardiovascular Diseases; Dose-Response Relationship, Drug | 1986 |
4 trials available for ketamine and Aging
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Comparison of the effects of clonidine and ketamine added to ropivacaine on stress hormone levels and the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Aging; Amides; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Lo | 2005 |
A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies.
Topics: Aging; Anesthetics, Intravenous; Body Surface Area; Body Weight; Calibration; Child; Child, Preschoo | 1997 |
42 other studies available for ketamine and Aging
| Article | Year |
|---|---|
Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques.
Topics: Aging; Anesthetics, Dissociative; Animals; Electromyography; Female; Ketamine; Macaca mulatta; Muscl | 2020 |
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
Topics: Aging; Anesthetics; Animals; Brain; Female; Ketamine; Light; Mice, Inbred C57BL; Microglia; Nerve Ne | 2021 |
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity.
Topics: Aging; Animals; Apoptosis; Cerebral Cortex; Environment; GABAergic Neurons; Ketamine; Mice, Inbred C | 2017 |
Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats.
Topics: Aging; Animals; Animals, Newborn; Dopamine; Excitatory Amino Acid Antagonists; Female; Hippocampus; | 2019 |
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt.
Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Female; Gene Expression Regulation, Deve | 2013 |
Effect of maternal deprivation on acetylcholinesterase activity and behavioral changes on the ketamine-induced animal model of schizophrenia.
Topics: Acetylcholinesterase; Aging; Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; | 2013 |
Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats.
Topics: Age Factors; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Drug Therapy, Combination; Human | 2013 |
Failed response to repeat intravenous ketamine infusions in geriatric patients with major depressive disorder.
Topics: Aged; Aging; Depressive Disorder, Treatment-Resistant; Female; Humans; Infusions, Intravenous; Ketam | 2014 |
Impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats.
Topics: Aging; Animals; Apoptosis; CA1 Region, Hippocampal; Cerebral Cortex; Dose-Response Relationship, Dru | 2014 |
Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice.
Topics: Aging; Animals; Behavior, Animal; Cerebral Cortex; Disks Large Homolog 4 Protein; Excitatory Amino A | 2015 |
Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats.
Topics: Aging; Anesthesia; Animals; Body Temperature; Cornea; Drug Combinations; Heart Rate; Infusions, Pare | 2015 |
Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia.
Topics: Aging; Anesthesia; Anesthetics; Animals; Blinking; Heart Rate; Injections, Intraperitoneal; Ketamine | 2016 |
Effects of the nicotinic agonist varenicline on the performance of tasks of cognition in aged and middle-aged rhesus and pigtail monkeys.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cognition; Drug Repositioning; Excitatory A | 2016 |
Effect of ketamine anesthesia on cognitive function and immune function in young rats.
Topics: Aging; Anesthesia; Animals; Apoptosis; Behavior, Animal; Cognition; Hippocampus; Immunity; Interleuk | 2016 |
Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia.
Topics: Adjuvants, Anesthesia; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Electroencephalography | 2008 |
Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats.
Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Body Weight; Carnitine; Excit | 2008 |
Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry.
Topics: Aging; Animals; Arteries; Brachial Artery; Echocardiography; Female; Heart Rate; Heart Ventricles; K | 2009 |
[Effect of orexin-A on recovery from ketamine anesthesia in aged rats].
Topics: Aging; Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Cognition; Delayed Emergence | 2009 |
The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma.
Topics: Acepromazine; Aging; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Axons; | 2012 |
Age-dependent effects of repeated amphetamine exposure on working memory in rats.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, | 2013 |
Age and anesthetic effects on murine electrocardiography.
Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi | 2003 |
Neurotoxicity of nitrous oxide and ketamine is more severe in aged than in young rat brain.
Topics: Aging; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Cerebral Cortex; Female; Ketamin | 2003 |
The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain.
Topics: Aging; Anesthetics; Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Female; Ket | 2005 |
Hematologic and serum biochemical values in aged female bonnet macaques (Macaca radiata) anesthetized with ketamine hydrochloride.
Topics: Aging; Alkaline Phosphatase; Anesthetics, Dissociative; Animals; Animals, Laboratory; Blood Chemical | 2006 |
[Importance of the ketamine-flunitrazepam combination in elective abortion].
Topics: Abortion, Induced; Adolescent; Adult; Aging; Anesthesia; Consciousness; Female; Flunitrazepam; Human | 1984 |
The hemogram, serum biochemistry, and electrolyte profile of aged rhesus monkeys (Macaca mulatta).
Topics: Age Factors; Aging; Alkaline Phosphatase; Anesthesia; Animals; Blood Cell Count; Blood Proteins; Ele | 1983 |
The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride.
Topics: Aging; Animals; Cattle; Female; Half-Life; Injections, Intravenous; Ketamine; Kinetics; Male; Preane | 1984 |
Age dependent ketamine pharmacodynamics in the pigtail monkey (Macaca nemestrina).
Topics: Aging; Animals; Electroencephalography; Half-Life; Haplorhini; Injections, Intravenous; Ketamine; Ki | 1980 |
Normative hematologic and serum biochemical values for adult and infant rhesus monkeys (Macaca mulatta) in a controlled laboratory environment.
Topics: Aging; Animals; Animals, Laboratory; Blood Cell Count; Blood Chemical Analysis; Blood Specimen Colle | 1994 |
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D | 1996 |
Hypoxia-induced dysfunction in developing rat neocortex.
Topics: Aging; Anesthetics, Intravenous; Animals; Calcium; Extracellular Space; Hypoxia; In Vitro Techniques | 1997 |
Pharmacological extension of the sensitive period for imprinting in Gallus domesticus.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Chickens; Darkness; Excitatory Amino Ac | 1997 |
N-methyl-D-aspartate receptor blockade affects polysialylated neural cell adhesion molecule expression and synaptic density during striatal development.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Corpus Striatum; Dizocilpine Maleate; Gene Expression R | 1999 |
On-bipolar cells and depolarising third-order neurons as the origin of the ERG-b-wave in the RCS rat.
Topics: Aging; Animals; Butyric Acid; Cell Polarity; Electroretinography; Extracellular Space; Ketamine; Mag | 2001 |
Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two free-breeding colonies.
Topics: Aging; Animals; Circadian Rhythm; Female; Glaucoma; Haplorhini; Intraocular Pressure; Ketamine; Long | 1979 |
Influence of age and sex on the duration of action ketamine in the rat [proceedings].
Topics: Aging; Animals; Female; Ketamine; Male; Rats; Sex Factors; Time Factors | 1977 |
Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg(2+)-free medium.
Topics: Aging; Animals; Cerebral Cortex; Culture Media; Electrodes; Electrophysiology; In Vitro Techniques; | 1991 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Influence of xenobiotics on bile flow and bile composition in rats--methodological approach.
Topics: Aging; Anesthesia; Animals; Bile; Body Water; Cholesterol; Female; Ketamine; Methods; Nephrectomy; R | 1990 |
Effects of ketamine on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Behavior, Animal; Ketamine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Re | 1989 |
Ontogenetic development of ketamine-induced sleeping time and electrocorticographic changes in rats.
Topics: Aging; Animals; Electroencephalography; Female; Ketamine; Male; Rats; Rats, Inbred Strains; Sleep | 1989 |
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Pot | 1986 |