ketamine has been researched along with Aging in 49 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Excerpt | Relevance | Reference |
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"An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
"An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 7.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
"The ketamine CRI rate was 19." | 5.56 | Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques. ( Biscola, NP; Christe, KL; Colman, RJ; Havton, LA, 2020) |
" Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 5.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
"While the effects of varenicline across the different behavioral tasks were modest, these data suggest that varenicline may have potential as a repurposed drug for disorders of cognition associated with aging (e." | 3.83 | Effects of the nicotinic agonist varenicline on the performance of tasks of cognition in aged and middle-aged rhesus and pigtail monkeys. ( Callahan, PM; Plagenhoef, M; Terry, AV, 2016) |
"The main objective of this study was to compare the effects of ketamine and xylazine in aging rats when coadministered intraperitoneally at high anesthetic doses." | 3.81 | Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats. ( Burns, P; Giroux, MC; Hélie, P; Vachon, P, 2015) |
"An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.68 | Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis. ( Mares, P; Rokyta, R; Velísek, L; Velísková, J, 1990) |
"An anticonvulsant action of ketamine, a noncompetitive NMDA receptor antagonist (1-40 mg/kg IP), on the metrazol-induced seizures was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days." | 3.67 | Effects of ketamine on metrazol-induced seizures during ontogenesis in rats. ( Blanková-Vanková, S; Mares, P; Mikolásová, R; Velísek, L, 1989) |
"As part of an ophthalmic and anthropometric survey of two free-breeding rhesus monkey (Macaca mulatta) populations, intraocular pressure (IOP) of 114 animals was measured under ketamine catalepsia with the use of a floating-tip pneumatonometer." | 3.66 | Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two free-breeding colonies. ( Bito, LZ; DeRousseau, CJ; Merritt, SQ, 1979) |
"Additionally, trisomy 21 (P = 0." | 2.76 | Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study. ( Bodian, C; Chakravarti, S; Hollinger, I; Hossain, S; Kin, N; Krol, M; Mittnacht, AJ; Nguyen, K; Srivastava, S; Weismann, C, 2011) |
"The ketamine beta-t1/2s were not dose related." | 2.68 | A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies. ( Domino, EF; Fekete, G; Kovacs, V; Stetson, P; Zsigmond, EK, 1997) |
" Pharmacokinetic parameters (T1/2 and AUC) increased and drug clearance decreased with aging, which strongly suggests that drug exposure is associated with the physiological results." | 1.43 | Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia. ( Beaudry, F; Burns, P; Giroux, MC; Hélie, P; Santamaria, R; Vachon, P, 2016) |
"Ketamine is a NMDA receptor (NMDAR) antagonist used in pediatric anesthesia." | 1.42 | Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice. ( Bénard, M; Brasse-Lagnel, C; Dupré, N; Gonzalez, BJ; Henry, VJ; Jégou, S; Lecointre, M; Leroux-Nicollet, I; Marret, S; Ramdani, Y; Roy, V; Vézier, C, 2015) |
" The rate constant of elimination of both drugs was greatly decreased and the elimination half-life was significantly greater in old compared with young rats." | 1.39 | Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats. ( Beaudry, F; Carrier, D; Castel, A; Vachon, P; Veilleux-Lemieux, D, 2013) |
"Body weight was decreased on PNDs 8-18 in PCP-treated pups and PNDs 8-10 in KET-treated pups." | 1.35 | Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats. ( Boctor, SY; Ferguson, SA; Wang, C, 2008) |
"Ketamine hydrochloride was administered intravenously to unpremedicated and xylazine-treated calves." | 1.27 | The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride. ( Waterman, AE, 1984) |
Timeframe | Studies, this research(%) | All Research% |
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pre-1990 | 10 (20.41) | 18.7374 |
1990's | 9 (18.37) | 18.2507 |
2000's | 11 (22.45) | 29.6817 |
2010's | 16 (32.65) | 24.3611 |
2020's | 3 (6.12) | 2.80 |
Authors | Studies |
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Mielke, N | 1 |
Johnson, S | 1 |
Bahl, A | 1 |
Fadladdin, YAJ | 1 |
Xue, M | 1 |
Zhang, X | 8 |
Chen, J | 3 |
Liu, F | 1 |
Xu, J | 3 |
Xie, J | 1 |
Yang, Y | 4 |
Yu, W | 1 |
Qiu, H | 1 |
Xue, J | 2 |
Jiang, J | 3 |
Liu, Y | 10 |
Shallom, SJ | 1 |
Zelazny, AM | 1 |
Giri, AR | 1 |
Kaur, N | 1 |
Yarrarapu, SNS | 1 |
Rottman Pietrzak, KA | 1 |
Santos, C | 1 |
Lowman, PE | 1 |
Niaz, S | 1 |
Franco, PM | 1 |
Sanghavi, DK | 1 |
Zhu, D | 1 |
Liang, R | 1 |
Li, Z | 4 |
Cheng, L | 1 |
Ren, J | 1 |
Guo, Y | 2 |
Wang, M | 2 |
Chai, H | 1 |
Niu, Q | 1 |
Yang, S | 2 |
Bai, J | 2 |
Yu, H | 2 |
Zhang, H | 2 |
Qin, X | 1 |
Sahrakorpi, N | 1 |
Engberg, E | 1 |
Stach-Lempinen, B | 1 |
Tammelin, TH | 1 |
Kulmala, J | 1 |
Roine, RP | 1 |
Koivusalo, SB | 1 |
Cheng, W | 1 |
Pang, H | 1 |
Campen, MJ | 1 |
Zhang, J | 6 |
Li, Y | 5 |
Gao, J | 1 |
Ren, D | 1 |
Ji, X | 1 |
Rothman, N | 1 |
Lan, Q | 1 |
Zheng, Y | 2 |
Leng, S | 1 |
Hu, Z | 2 |
Tang, J | 4 |
Dong, Q | 2 |
Song, N | 1 |
Qin, N | 1 |
Chen, C | 1 |
Sun, X | 2 |
Easton, J | 1 |
Mulder, H | 1 |
Plyler, E | 1 |
Neale, G | 1 |
Walker, E | 1 |
Li, Q | 1 |
Ma, X | 2 |
Chen, X | 4 |
Huang, IC | 1 |
Yasui, Y | 1 |
Ness, KK | 1 |
Hudson, MM | 1 |
Robison, LL | 1 |
Wang, Z | 3 |
Subota, A | 1 |
Spotswood, N | 1 |
Roach, M | 1 |
Goodarzi, Z | 1 |
Holroyd-Leduc, J | 1 |
Park, EA | 1 |
Graves, SA | 1 |
Menda, Y | 1 |
Halim, AA | 1 |
Alsayed, B | 1 |
Embarak, S | 1 |
Yaseen, T | 1 |
Dabbous, S | 1 |
Fontaine, O | 1 |
Dueluzeau, R | 1 |
Raibaud, P | 1 |
Chabanet, C | 1 |
Popoff, MR | 1 |
Badoual, J | 1 |
Gabilan, JC | 1 |
Andremont, A | 1 |
Gómez, L | 1 |
Andrés, S | 1 |
Sánchez, J | 1 |
Alonso, JM | 1 |
Rey, J | 1 |
López, F | 1 |
Jiménez, A | 1 |
Yan, Z | 1 |
Zhou, L | 1 |
Zhao, Y | 3 |
Wang, J | 7 |
Huang, L | 2 |
Hu, K | 1 |
Liu, H | 4 |
Wang, H | 3 |
Guo, Z | 1 |
Song, Y | 1 |
Huang, H | 4 |
Yang, R | 1 |
Owen, TW | 1 |
Al-Kaysi, RO | 1 |
Bardeen, CJ | 1 |
Cheng, Q | 1 |
Wu, S | 1 |
Cheng, T | 1 |
Zhou, X | 1 |
Wang, B | 4 |
Zhang, Q | 4 |
Wu, X | 2 |
Yao, Y | 3 |
Ochiai, T | 1 |
Ishiguro, H | 2 |
Nakano, R | 2 |
Kubota, Y | 2 |
Hara, M | 1 |
Sunada, K | 1 |
Hashimoto, K | 1 |
Kajioka, J | 1 |
Fujishima, A | 1 |
Jiao, J | 3 |
Gai, QY | 3 |
Wang, W | 2 |
Zang, YP | 2 |
Niu, LL | 2 |
Fu, YJ | 3 |
Wang, X | 6 |
Yao, LP | 1 |
Qin, QP | 1 |
Wang, ZY | 1 |
Liu, J | 4 |
Aleksic Sabo, V | 1 |
Knezevic, P | 1 |
Borges-Argáez, R | 1 |
Chan-Balan, R | 1 |
Cetina-Montejo, L | 1 |
Ayora-Talavera, G | 1 |
Sansores-Peraza, P | 1 |
Gómez-Carballo, J | 1 |
Cáceres-Farfán, M | 1 |
Jang, J | 1 |
Akin, D | 1 |
Bashir, R | 1 |
Yu, Z | 1 |
Zhu, J | 2 |
Jiang, H | 1 |
He, C | 2 |
Xiao, Z | 1 |
Sun, Q | 1 |
Han, D | 1 |
Lei, H | 1 |
Zhao, K | 2 |
Zhu, L | 1 |
Li, X | 4 |
Fu, H | 2 |
Wilson, BK | 1 |
Step, DL | 1 |
Maxwell, CL | 1 |
Gifford, CA | 1 |
Richards, CJ | 1 |
Krehbiel, CR | 1 |
Warner, JM | 1 |
Doerr, AJ | 1 |
Erickson, GE | 1 |
Guretzky, JA | 1 |
Rasby, RJ | 1 |
Watson, AK | 1 |
Klopfenstein, TJ | 1 |
Sun, Y | 4 |
Liu, Z | 3 |
Pham, TD | 1 |
Lee, BK | 1 |
Yang, FC | 1 |
Wu, KH | 1 |
Lin, WP | 1 |
Hu, MK | 1 |
Lin, L | 3 |
Shao, J | 1 |
Sun, M | 1 |
Xu, G | 1 |
Xu, N | 1 |
Wang, R | 1 |
Liu, S | 1 |
He, H | 1 |
Dong, X | 2 |
Yang, M | 2 |
Yang, Q | 1 |
Duan, S | 1 |
Yu, Y | 2 |
Han, J | 2 |
Zhang, C | 4 |
Chen, L | 2 |
Yang, X | 2 |
Li, W | 3 |
Wang, T | 2 |
Campbell, DA | 1 |
Gao, K | 1 |
Zager, RA | 1 |
Johnson, ACM | 1 |
Guillem, A | 1 |
Keyser, J | 1 |
Singh, B | 1 |
Steubl, D | 1 |
Schneider, MP | 1 |
Meiselbach, H | 1 |
Nadal, J | 1 |
Schmid, MC | 1 |
Saritas, T | 1 |
Krane, V | 1 |
Sommerer, C | 1 |
Baid-Agrawal, S | 1 |
Voelkl, J | 1 |
Kotsis, F | 1 |
Köttgen, A | 1 |
Eckardt, KU | 1 |
Scherberich, JE | 1 |
Li, H | 4 |
Yao, L | 2 |
Sun, L | 3 |
Zhu, Z | 1 |
Naren, N | 1 |
Zhang, XX | 2 |
Gentile, GL | 1 |
Rupert, AS | 1 |
Carrasco, LI | 1 |
Garcia, EM | 1 |
Kumar, NG | 1 |
Walsh, SW | 1 |
Jefferson, KK | 1 |
Guest, RL | 1 |
Samé Guerra, D | 1 |
Wissler, M | 1 |
Grimm, J | 1 |
Silhavy, TJ | 1 |
Lee, JH | 2 |
Yoo, JS | 1 |
Kim, Y | 1 |
Kim, JS | 2 |
Lee, EJ | 1 |
Roe, JH | 1 |
Delorme, M | 1 |
Bouchard, PA | 1 |
Simon, M | 1 |
Simard, S | 1 |
Lellouche, F | 1 |
D'Urzo, KA | 1 |
Mok, F | 1 |
D'Urzo, AD | 1 |
Koneru, B | 1 |
Lopez, G | 1 |
Farooqi, A | 1 |
Conkrite, KL | 1 |
Nguyen, TH | 1 |
Macha, SJ | 1 |
Modi, A | 1 |
Rokita, JL | 1 |
Urias, E | 1 |
Hindle, A | 1 |
Davidson, H | 1 |
Mccoy, K | 1 |
Nance, J | 1 |
Yazdani, V | 1 |
Irwin, MS | 1 |
Wheeler, DA | 1 |
Maris, JM | 1 |
Diskin, SJ | 1 |
Reynolds, CP | 1 |
Abhilash, L | 1 |
Kalliyil, A | 1 |
Sheeba, V | 1 |
Hartley, AM | 2 |
Meunier, B | 2 |
Pinotsis, N | 1 |
Maréchal, A | 2 |
Xu, JY | 1 |
Genko, N | 1 |
Haraux, F | 1 |
Rich, PR | 1 |
Kamalanathan, M | 1 |
Doyle, SM | 1 |
Xu, C | 1 |
Achberger, AM | 1 |
Wade, TL | 1 |
Schwehr, K | 1 |
Santschi, PH | 1 |
Sylvan, JB | 1 |
Quigg, A | 1 |
Leong, W | 1 |
Xu, W | 2 |
Gao, S | 1 |
Zhai, X | 1 |
Wang, C | 3 |
Gilson, E | 1 |
Ye, J | 1 |
Lu, Y | 1 |
Yan, R | 1 |
Zhang, Y | 6 |
You, Q | 1 |
Cai, Q | 1 |
Yang, D | 1 |
Gu, S | 1 |
Dai, H | 1 |
Zhao, X | 1 |
Gui, C | 1 |
Gui, J | 1 |
Wu, PK | 1 |
Hong, SK | 1 |
Starenki, D | 1 |
Oshima, K | 1 |
Shao, H | 1 |
Gestwicki, JE | 1 |
Tsai, S | 1 |
Park, JI | 1 |
Wang, Y | 7 |
Zhao, R | 1 |
Gu, Z | 1 |
Dong, C | 2 |
Guo, G | 1 |
Li, L | 4 |
Barrett, HE | 1 |
Meester, EJ | 1 |
van Gaalen, K | 1 |
van der Heiden, K | 1 |
Krenning, BJ | 1 |
Beekman, FJ | 1 |
de Blois, E | 1 |
de Swart, J | 1 |
Verhagen, HJ | 1 |
Maina, T | 1 |
Nock, BA | 1 |
Norenberg, JP | 1 |
de Jong, M | 1 |
Gijsen, FJH | 1 |
Bernsen, MR | 1 |
Martínez-Milla, J | 1 |
Galán-Arriola, C | 1 |
Carnero, M | 1 |
Cobiella, J | 1 |
Pérez-Camargo, D | 1 |
Bautista-Hernández, V | 1 |
Rigol, M | 1 |
Solanes, N | 1 |
Villena-Gutierrez, R | 1 |
Lobo, M | 1 |
Mateo, J | 1 |
Vilchez-Tschischke, JP | 1 |
Salinas, B | 1 |
Cussó, L | 1 |
López, GJ | 1 |
Fuster, V | 1 |
Desco, M | 1 |
Sanchez-González, J | 1 |
Ibanez, B | 1 |
van den Berg, P | 1 |
Schweitzer, DH | 1 |
van Haard, PMM | 1 |
Geusens, PP | 1 |
van den Bergh, JP | 1 |
Zhu, X | 1 |
Huang, X | 2 |
Xu, H | 2 |
Yang, G | 2 |
Lin, Z | 1 |
Salem, HF | 1 |
Nafady, MM | 1 |
Kharshoum, RM | 1 |
Abd El-Ghafar, OA | 1 |
Farouk, HO | 1 |
Domiciano, D | 1 |
Nery, FC | 1 |
de Carvalho, PA | 1 |
Prudente, DO | 1 |
de Souza, LB | 1 |
Chalfun-Júnior, A | 1 |
Paiva, R | 1 |
Marchiori, PER | 1 |
Lu, M | 2 |
An, Z | 1 |
Li, J | 8 |
Du, S | 1 |
Zhou, H | 1 |
Cui, J | 1 |
Wu, W | 1 |
Song, J | 1 |
Lian, Q | 1 |
Uddin Ahmad, Z | 1 |
Gang, DD | 1 |
Konggidinata, MI | 1 |
Gallo, AA | 1 |
Zappi, ME | 1 |
Yang, TWW | 1 |
Johari, Y | 1 |
Burton, PR | 1 |
Earnest, A | 1 |
Shaw, K | 1 |
Hare, JL | 1 |
Brown, WA | 1 |
Kim, GA | 1 |
Han, S | 1 |
Choi, GH | 1 |
Choi, J | 1 |
Lim, YS | 1 |
Gallo, A | 1 |
Cancelli, C | 1 |
Ceron, E | 1 |
Covino, M | 1 |
Capoluongo, E | 1 |
Pocino, K | 1 |
Ianiro, G | 1 |
Cammarota, G | 1 |
Gasbarrini, A | 1 |
Montalto, M | 1 |
Somasundar, Y | 1 |
Lu, IC | 1 |
Mills, MR | 1 |
Qian, LY | 1 |
Olivares, X | 1 |
Ryabov, AD | 1 |
Collins, TJ | 1 |
Zhao, L | 1 |
Doddipatla, S | 1 |
Thomas, AM | 1 |
Nikolayev, AA | 1 |
Galimova, GR | 1 |
Azyazov, VN | 1 |
Mebel, AM | 1 |
Kaiser, RI | 1 |
Guo, S | 1 |
Yang, P | 1 |
Yu, X | 3 |
Wu, Y | 2 |
Yu, B | 2 |
Han, B | 1 |
George, MW | 1 |
Moor, MB | 1 |
Bonny, O | 1 |
Langenberg, E | 1 |
Paik, H | 1 |
Smith, EH | 1 |
Nair, HP | 1 |
Hanke, I | 1 |
Ganschow, S | 1 |
Catalan, G | 1 |
Domingo, N | 1 |
Schlom, DG | 1 |
Assefa, MK | 1 |
Wu, G | 2 |
Hayton, TW | 1 |
Becker, B | 1 |
Enikeev, D | 1 |
Netsch, C | 1 |
Gross, AJ | 1 |
Laukhtina, E | 1 |
Glybochko, P | 1 |
Rapoport, L | 1 |
Herrmann, TRW | 1 |
Taratkin, M | 1 |
Dai, W | 1 |
Shi, J | 2 |
Carreno, J | 1 |
Kloner, RA | 1 |
Pickersgill, NA | 1 |
Vetter, JM | 1 |
Kim, EH | 1 |
Cope, SJ | 1 |
Du, K | 1 |
Venkatesh, R | 1 |
Giardina, JD | 1 |
Saad, NES | 1 |
Bhayani, SB | 1 |
Figenshau, RS | 1 |
Eriksson, J | 1 |
Landfeldt, E | 1 |
Ireland, S | 1 |
Jackson, C | 1 |
Wyatt, E | 1 |
Gaudig, M | 1 |
Stancill, JS | 1 |
Happ, JT | 1 |
Broniowska, KA | 1 |
Hogg, N | 1 |
Corbett, JA | 1 |
Tang, LF | 1 |
Bi, YL | 1 |
Fan, Y | 2 |
Sun, YB | 1 |
Wang, AL | 1 |
Xiao, BH | 1 |
Wang, LF | 1 |
Qiu, SW | 1 |
Guo, SW | 1 |
Wáng, YXJ | 1 |
Sun, J | 2 |
Chu, S | 1 |
Pan, Q | 1 |
Li, D | 2 |
Zheng, S | 2 |
Ma, L | 1 |
Wang, L | 3 |
Hu, T | 1 |
Wang, F | 1 |
Han, Z | 1 |
Yin, Z | 1 |
Ge, X | 1 |
Xie, K | 1 |
Lei, P | 1 |
Dias-Santagata, D | 1 |
Lennerz, JK | 1 |
Sadow, PM | 1 |
Frazier, RP | 1 |
Govinda Raju, S | 1 |
Henry, D | 1 |
Chung, T | 1 |
Kherani, J | 1 |
Rothenberg, SM | 1 |
Wirth, LJ | 1 |
Marti, CN | 1 |
Choi, NG | 1 |
Bae, SJ | 1 |
Ni, L | 1 |
Luo, X | 1 |
Dai, T | 1 |
Lee, R | 1 |
Fleischer, AS | 1 |
Wemhoff, AP | 1 |
Ford, CR | 1 |
Kleppinger, EL | 1 |
Helms, K | 1 |
Bush, AA | 1 |
Luna-Abanto, J | 1 |
García Ruiz, L | 1 |
Laura Martinez, J | 1 |
Álvarez Larraondo, M | 1 |
Villoslada Terrones, V | 1 |
Dukic, L | 1 |
Maric, N | 1 |
Simundic, AM | 1 |
Chogtu, B | 1 |
Ommurugan, B | 1 |
Thomson, SR | 1 |
Kalthur, SG | 1 |
Benidir, M | 1 |
El Massoudi, S | 1 |
El Ghadraoui, L | 1 |
Lazraq, A | 1 |
Benjelloun, M | 1 |
Errachidi, F | 1 |
Cassar, M | 1 |
Law, AD | 1 |
Chow, ES | 1 |
Giebultowicz, JM | 1 |
Kretzschmar, D | 1 |
Salonurmi, T | 1 |
Nabil, H | 1 |
Ronkainen, J | 1 |
Hyötyläinen, T | 1 |
Hautajärvi, H | 1 |
Savolainen, MJ | 1 |
Tolonen, A | 1 |
Orešič, M | 1 |
Känsäkoski, P | 1 |
Rysä, J | 1 |
Hakkola, J | 1 |
Hukkanen, J | 1 |
Zhu, N | 1 |
Du, Q | 1 |
Hao, P | 1 |
Cao, X | 1 |
Li, CX | 1 |
Zhao, S | 1 |
Luo, XM | 1 |
Feng, JX | 1 |
Gonzalez-Cotto, M | 1 |
Guo, L | 2 |
Karwan, M | 1 |
Sen, SK | 1 |
Barb, J | 1 |
Collado, CJ | 1 |
Elloumi, F | 1 |
Palmieri, EM | 1 |
Boelte, K | 1 |
Kolodgie, FD | 1 |
Finn, AV | 1 |
Biesecker, LG | 1 |
McVicar, DW | 1 |
Qu, F | 1 |
Deng, Z | 1 |
Xie, Y | 2 |
Chen, Z | 2 |
Luo, W | 1 |
Xiong, D | 1 |
Zhao, D | 1 |
Fang, J | 1 |
Zhou, Z | 1 |
Niu, PP | 1 |
Song, B | 1 |
Xu, YM | 1 |
Zhang, Z | 2 |
Qiu, N | 1 |
Yin, J | 1 |
Guo, W | 1 |
Liu, M | 2 |
Liu, T | 2 |
Chen, D | 5 |
Luo, K | 1 |
He, Z | 2 |
Zheng, G | 1 |
Xu, F | 1 |
Sun, W | 1 |
Yin, F | 1 |
van Hest, JCM | 1 |
Du, L | 2 |
Shi, X | 1 |
Kang, S | 1 |
Duan, W | 1 |
Zhang, S | 2 |
Feng, J | 2 |
Qi, N | 1 |
Shen, G | 1 |
Ren, H | 1 |
Shang, Q | 1 |
Zhao, W | 2 |
Yang, Z | 2 |
Jiang, X | 2 |
Alame, M | 1 |
Cornillot, E | 1 |
Cacheux, V | 1 |
Tosato, G | 1 |
Four, M | 1 |
De Oliveira, L | 1 |
Gofflot, S | 1 |
Delvenne, P | 1 |
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Ye, JN | 1 |
Jia, XB | 1 |
Yang, TD | 1 |
Kin, N | 1 |
Weismann, C | 1 |
Chakravarti, S | 1 |
Bodian, C | 1 |
Hossain, S | 1 |
Krol, M | 1 |
Hollinger, I | 1 |
Nguyen, K | 1 |
Mittnacht, AJ | 1 |
Cone, FE | 1 |
Steinhart, MR | 1 |
Oglesby, EN | 1 |
Kalesnykas, G | 1 |
Pease, ME | 1 |
Quigley, HA | 1 |
Sherrill, LK | 1 |
Stanis, JJ | 1 |
Gulley, JM | 1 |
Chaves, AA | 1 |
Dech, SJ | 1 |
Nakayama, T | 1 |
Hamlin, RL | 1 |
Bauer, JA | 1 |
Carnes, CA | 1 |
Beals, JK | 1 |
Carter, LB | 2 |
Jevtovic-Todorovic, V | 2 |
Eilers, H | 1 |
Niemann, C | 1 |
Akbas, M | 1 |
Akbas, H | 1 |
Yegin, A | 1 |
Sahin, N | 1 |
Titiz, TA | 1 |
Venkatesan, R | 1 |
Nagarajan, P | 1 |
Rajaretnam, RS | 1 |
Majumdar, SS | 1 |
Cordebar, R | 1 |
Kessler, MJ | 1 |
Rawlins, RG | 1 |
London, WT | 1 |
Waterman, AE | 2 |
Hargrove, JC | 1 |
Heavner, JE | 1 |
Guthrie, RD | 1 |
Morton, WR | 1 |
Fernie, S | 1 |
Wrenshall, E | 1 |
Malcolm, S | 1 |
Bryce, F | 1 |
Arnold, DL | 1 |
Roder, JD | 1 |
Sangiah, S | 1 |
Luhmann, HJ | 1 |
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Velísek, L | 2 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Evaluation of a Peri-Operative Continuous Bilateral Erector Spinae Plane (ESP) Continuous Catheter After Open Cardiac Surgery in Adults[NCT03901612] | Phase 4 | 0 participants (Actual) | Interventional | 2019-01-05 | Withdrawn (stopped due to covid and surgeon left) | ||
Bilateral Erector Spinae Plane (ESP) Catheters Versus Single Shot ESP Block for Open Heart Surgery in Infants[NCT03593642] | 40 participants (Actual) | Interventional | 2018-10-01 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for ketamine and Aging
Article | Year |
---|---|
Topics: Adult; Aging; Aluminum; Alzheimer Disease; Animals; Anti-Bacterial Agents; Artemisia annua; Body Mas | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Clinically important drug interactions with intravenous anaesthetics in older patients.
Topics: Aged; Aging; Anesthetics, Intravenous; Barbiturates; Benzodiazepines; Drug Interactions; Etomidate; | 2003 |
Newborn anaesthesia: pharmacological considerations.
Topics: Aging; Anesthesia; Anesthesia, Inhalation; Cardiovascular Diseases; Dose-Response Relationship, Drug | 1986 |
4 trials available for ketamine and Aging
Article | Year |
---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Factors affecting the decision to defer endotracheal extubation after surgery for congenital heart disease: a prospective observational study.
Topics: Adolescent; Aging; Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Dissociative; Anesthetic | 2011 |
Comparison of the effects of clonidine and ketamine added to ropivacaine on stress hormone levels and the duration of caudal analgesia.
Topics: Adjuvants, Anesthesia; Aging; Amides; Anesthesia, Caudal; Anesthetics, Dissociative; Anesthetics, Lo | 2005 |
A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies.
Topics: Aging; Anesthetics, Intravenous; Body Surface Area; Body Weight; Calibration; Child; Child, Preschoo | 1997 |
42 other studies available for ketamine and Aging
Article | Year |
---|---|
Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques.
Topics: Aging; Anesthetics, Dissociative; Animals; Electromyography; Female; Ketamine; Macaca mulatta; Muscl | 2020 |
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
Topics: Aging; Anesthetics; Animals; Brain; Female; Ketamine; Light; Mice, Inbred C57BL; Microglia; Nerve Ne | 2021 |
Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity.
Topics: Aging; Animals; Apoptosis; Cerebral Cortex; Environment; GABAergic Neurons; Ketamine; Mice, Inbred C | 2017 |
Sex-dependent changes in ketamine-induced locomotor activity and ketamine pharmacokinetics in preweanling, adolescent, and adult rats.
Topics: Aging; Animals; Animals, Newborn; Dopamine; Excitatory Amino Acid Antagonists; Female; Hippocampus; | 2019 |
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt.
Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Female; Gene Expression Regulation, Deve | 2013 |
Effect of maternal deprivation on acetylcholinesterase activity and behavioral changes on the ketamine-induced animal model of schizophrenia.
Topics: Acetylcholinesterase; Aging; Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; | 2013 |
Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats.
Topics: Age Factors; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Drug Therapy, Combination; Human | 2013 |
Failed response to repeat intravenous ketamine infusions in geriatric patients with major depressive disorder.
Topics: Aged; Aging; Depressive Disorder, Treatment-Resistant; Female; Humans; Infusions, Intravenous; Ketam | 2014 |
Impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats.
Topics: Aging; Animals; Apoptosis; CA1 Region, Hippocampal; Cerebral Cortex; Dose-Response Relationship, Dru | 2014 |
Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice.
Topics: Aging; Animals; Behavior, Animal; Cerebral Cortex; Disks Large Homolog 4 Protein; Excitatory Amino A | 2015 |
Anesthetic and pathological changes following high doses of ketamine and xylazine in Sprague Dawley rats.
Topics: Aging; Anesthesia; Animals; Body Temperature; Cornea; Drug Combinations; Heart Rate; Infusions, Pare | 2015 |
Physiological, pharmacokinetic and liver metabolism comparisons between 3-, 6-, 12- and 18-month-old male Sprague Dawley rats under ketamine-xylazine anesthesia.
Topics: Aging; Anesthesia; Anesthetics; Animals; Blinking; Heart Rate; Injections, Intraperitoneal; Ketamine | 2016 |
Effects of the nicotinic agonist varenicline on the performance of tasks of cognition in aged and middle-aged rhesus and pigtail monkeys.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cognition; Drug Repositioning; Excitatory A | 2016 |
Effect of ketamine anesthesia on cognitive function and immune function in young rats.
Topics: Aging; Anesthesia; Animals; Apoptosis; Behavior, Animal; Cognition; Hippocampus; Immunity; Interleuk | 2016 |
Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia.
Topics: Adjuvants, Anesthesia; Aging; Anesthesia; Anesthetics, Dissociative; Animals; Electroencephalography | 2008 |
Neonatal PCP is more potent than ketamine at modifying preweaning behaviors of Sprague-Dawley rats.
Topics: Aging; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Body Weight; Carnitine; Excit | 2008 |
Characterization of arterial wave reflection in healthy bonnet macaques: feasibility of applanation tonometry.
Topics: Aging; Animals; Arteries; Brachial Artery; Echocardiography; Female; Heart Rate; Heart Ventricles; K | 2009 |
[Effect of orexin-A on recovery from ketamine anesthesia in aged rats].
Topics: Aging; Anesthesia Recovery Period; Anesthetics, Dissociative; Animals; Cognition; Delayed Emergence | 2009 |
The effects of anesthesia, mouse strain and age on intraocular pressure and an improved murine model of experimental glaucoma.
Topics: Acepromazine; Aging; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Axons; | 2012 |
Age-dependent effects of repeated amphetamine exposure on working memory in rats.
Topics: Aging; Amphetamine; Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, | 2013 |
Age and anesthetic effects on murine electrocardiography.
Topics: Aging; Anesthetics, Combined; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electrocardi | 2003 |
Neurotoxicity of nitrous oxide and ketamine is more severe in aged than in young rat brain.
Topics: Aging; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Cerebral Cortex; Female; Ketamin | 2003 |
The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain.
Topics: Aging; Anesthetics; Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Female; Ket | 2005 |
Hematologic and serum biochemical values in aged female bonnet macaques (Macaca radiata) anesthetized with ketamine hydrochloride.
Topics: Aging; Alkaline Phosphatase; Anesthetics, Dissociative; Animals; Animals, Laboratory; Blood Chemical | 2006 |
[Importance of the ketamine-flunitrazepam combination in elective abortion].
Topics: Abortion, Induced; Adolescent; Adult; Aging; Anesthesia; Consciousness; Female; Flunitrazepam; Human | 1984 |
The hemogram, serum biochemistry, and electrolyte profile of aged rhesus monkeys (Macaca mulatta).
Topics: Age Factors; Aging; Alkaline Phosphatase; Anesthesia; Animals; Blood Cell Count; Blood Proteins; Ele | 1983 |
The pharmacokinetics of ketamine administered intravenously in calves and the modifying effect of premedication with xylazine hydrochloride.
Topics: Aging; Animals; Cattle; Female; Half-Life; Injections, Intravenous; Ketamine; Kinetics; Male; Preane | 1984 |
Age dependent ketamine pharmacodynamics in the pigtail monkey (Macaca nemestrina).
Topics: Aging; Animals; Electroencephalography; Half-Life; Haplorhini; Injections, Intravenous; Ketamine; Ki | 1980 |
Normative hematologic and serum biochemical values for adult and infant rhesus monkeys (Macaca mulatta) in a controlled laboratory environment.
Topics: Aging; Animals; Animals, Laboratory; Blood Cell Count; Blood Chemical Analysis; Blood Specimen Colle | 1994 |
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D | 1996 |
Hypoxia-induced dysfunction in developing rat neocortex.
Topics: Aging; Anesthetics, Intravenous; Animals; Calcium; Extracellular Space; Hypoxia; In Vitro Techniques | 1997 |
Pharmacological extension of the sensitive period for imprinting in Gallus domesticus.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Animals, Newborn; Chickens; Darkness; Excitatory Amino Ac | 1997 |
N-methyl-D-aspartate receptor blockade affects polysialylated neural cell adhesion molecule expression and synaptic density during striatal development.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Corpus Striatum; Dizocilpine Maleate; Gene Expression R | 1999 |
On-bipolar cells and depolarising third-order neurons as the origin of the ERG-b-wave in the RCS rat.
Topics: Aging; Animals; Butyric Acid; Cell Polarity; Electroretinography; Extracellular Space; Ketamine; Mag | 2001 |
Intraocular pressure of rhesus monkey (Macaca mulatta). I. An initial survey of two free-breeding colonies.
Topics: Aging; Animals; Circadian Rhythm; Female; Glaucoma; Haplorhini; Intraocular Pressure; Ketamine; Long | 1979 |
Influence of age and sex on the duration of action ketamine in the rat [proceedings].
Topics: Aging; Animals; Female; Ketamine; Male; Rats; Sex Factors; Time Factors | 1977 |
Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg(2+)-free medium.
Topics: Aging; Animals; Cerebral Cortex; Culture Media; Electrodes; Electrophysiology; In Vitro Techniques; | 1991 |
Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis.
Topics: Aging; Animals; Ataxia; Bicuculline; Ketamine; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inb | 1990 |
Influence of xenobiotics on bile flow and bile composition in rats--methodological approach.
Topics: Aging; Anesthesia; Animals; Bile; Body Water; Cholesterol; Female; Ketamine; Methods; Nephrectomy; R | 1990 |
Effects of ketamine on metrazol-induced seizures during ontogenesis in rats.
Topics: Aging; Animals; Behavior, Animal; Ketamine; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Re | 1989 |
Ontogenetic development of ketamine-induced sleeping time and electrocorticographic changes in rats.
Topics: Aging; Animals; Electroencephalography; Female; Ketamine; Male; Rats; Rats, Inbred Strains; Sleep | 1989 |
Ketamine selectively suppresses synchronized afterdischarges in immature hippocampus.
Topics: Aging; Animals; Aspartic Acid; Evoked Potentials; Hippocampus; Iontophoresis; Ketamine; Membrane Pot | 1986 |