Page last updated: 2024-10-29

ketamine and Shingles

ketamine has been researched along with Shingles in 8 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

Excerpt	Relevance	Reference
"Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine."	7.71	[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001)
" The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved."	5.29	Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996)
"Four patients with postherpetic neuralgia had their pain alleviated by epidural administration of ketamine."	3.71	[Usefulness of epidural administration of ketamine for relief of postherpetic neuralgia]. ( Ikeda, M; Machida, K; Mikawa, Y; Mizuno, J; Sugimoto, S, 2001)
"A 74 year-old woman with a 6-month history of RSD following herpes zoster on her right arm was treated with stellate ganglion blocks (SGB), continuous epidural block (CEB) and continuous intravenous infusion of ketamine known as one of the NMDA receptor blockers."	3.69	[A case of RSD with complete disappearance of symptoms following intravenous ketamine infusion combined with stellate ganglion block and continuous epidural block]. ( Arakawa, H; Kato, J; Kishimoto, N; Ogawa, S; Suzuki, H; Suzuki, T, 1995)
"A post-herpetic neuralgia is thought to be a neuropathic pain due to the irreversible nerve injury and sensitization."	2.41	[Herpes zoster and post-herpetic neuralgia]. ( Hashizume, K, 2001)
" The result strongly suggests a synergy from this combination that warrants a formal study of the dose-response relationship involved in this treatment and the mechanism by which this effect is achieved."	1.29	Epidural coadministration of ketamine, morphine and bupivacaine attenuates post-herpetic neuralgia--a case report. ( Cherng, CH; Ho, ST; Liaw, WJ; Shen, TT; Wong, CS, 1996)

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (37.50)	18.2507
2000's	4 (50.00)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Griffin, JR	1
Davis, MD	1
Quan, D	1
Wellish, M	1
Gilden, DH	1
Lovitt, S	1
Kishimoto, N	1
Kato, J	1
Suzuki, T	1
Arakawa, H	1
Ogawa, S	1
Suzuki, H	1
Wong, CS	1
Shen, TT	1
Liaw, WJ	1
Cherng, CH	1
Ho, ST	1
Klepstad, P	1
Borchgrevink, PC	1
Mizuno, J	1
Sugimoto, S	1
Ikeda, M	2
Machida, K	1
Mikawa, Y	1
Hashizume, K	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]			Phase 2	13 participants (Actual)	Interventional	2017-05-23	Terminated (stopped due to Efficacy was not seen after interim analysis)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

Intervention	Intensity score (Mean)
Topical KeAmLi Combo	62.7
Topical Ketamine	63.1
Topical Amitriptyline	69.2
Topical Lidocaine	65.8
Topical Vehicle	61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,

Intervention	mN (Mean)
	Mechanical Detection Threshold	Mechanical Pain Threshold
Topical Amitriptyline	3.573423965	152.4768146
Topical KeAmLi Combo	3.519376956	152.3293608
Topical Ketamine	3.464204768	135.9
Topical Lidocaine	3.546037659	126.9
Topical Vehicle	3.525692637	148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes