ketamine has been researched along with Endotoxin Shock in 24 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although ketamine administration decreased the severity of hypotension and acidosis in endotoxemic rats, ketamine administration may not have additive beneficial antiinflammatory effects during hypothermia." | 7.72 | The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Takemoto, Y; Taniguchi, T; Yamamoto, K, 2004) |
| "The effects of norepinephrine and dobutamine were compared during endotoxin shock in dogs anesthetized either with enflurane (E: 1." | 7.68 | Adrenergic support during anesthesia in experimental endotoxin shock: norepinephrine versus dobutamine. ( de Rood, M; Engelman, E; Gilbart, E; Van der Linden, P; Vincent, JL, 1991) |
| "The ketamine-treated rats were injected with 100 mg/kg of ketamine intramuscularly 30 min before LPS (0." | 5.29 | Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. ( Koga, K; Matsumoto, T; Ogata, M; Shigematsu, A; Takenaka, I, 1994) |
| "Although ketamine administration decreased the severity of hypotension and acidosis in endotoxemic rats, ketamine administration may not have additive beneficial antiinflammatory effects during hypothermia." | 3.72 | The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Takemoto, Y; Taniguchi, T; Yamamoto, K, 2004) |
| "The effects of norepinephrine and dobutamine were compared during endotoxin shock in dogs anesthetized either with enflurane (E: 1." | 3.68 | Adrenergic support during anesthesia in experimental endotoxin shock: norepinephrine versus dobutamine. ( de Rood, M; Engelman, E; Gilbart, E; Van der Linden, P; Vincent, JL, 1991) |
| "Patients with septic shock commonly require endotracheal intubation under general anaesthesia in the operating theatre, the emergency department, and the intensive care unit." | 3.01 | The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial. ( Almenesey, T; Fathy, S; Gado, AA; Hamden, GA; Hasanin, A; Hosny, O; Mokhtar, A; Mostafa, M; Ramzy, E; Safina, AG; Sarhan, K, 2021) |
| "Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist that provides both amnesia and analgesia without depressing respiratory drive or blood pressure." | 1.48 | A Non-Comparative Prospective Pilot Study of Ketamine for Sedation in Adult Septic Shock. ( Boyer, NL; Mount, CA; Reese, JM; Sullivan, VF, 2018) |
| "Septic shock was replicated by intraperitoneal injection of 20 mg/kg lipopolysaccharide (LPS)." | 1.34 | [Effect of ketamine on endotoxin-induced septic shock in rats and its mechanism]. ( Liu, H; Xiao, H; Xu, HW; Zhang, L, 2007) |
| "We reviewed 159 septic shock patients admitted to our intensive care unit (ICU) over a 40-month period to study the association between induction agent and clinical outcome, including vasopressor, inotrope, and steroid therapy." | 1.34 | Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. ( McKeown, DW; Ray, DC, 2007) |
| "Ketamine could increase the expression of HSP70 in rat liver, restrain the release of TNF-alpha caused by endotoxin, and raise the survival rates of rats with septic shock." | 1.31 | [The effect of ketamine on the expression of HSP70 induced by endotoxin in liver of rat]. ( Liu, B; Wang, Q; Xiao, H; Zhang, L, 2001) |
| "coli bacteremia was studied in rats and compared to the effect of two other anesthetic procedures in previously published studies." | 1.30 | E. Coli bacteremia-induced changes in the skeletal muscle microcirculation vary with anesthetics. ( Garrison, RN; Harris, PD; Lüebbe, AS, 1998) |
| "The ketamine-treated rats were injected with 100 mg/kg of ketamine intramuscularly 30 min before LPS (0." | 1.29 | Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model. ( Koga, K; Matsumoto, T; Ogata, M; Shigematsu, A; Takenaka, I, 1994) |
| "Ketamine was used as the main anaesthetic." | 1.28 | Ketamine anaesthesia in a patient with septic shock. ( Kirvelä, M; Lindgren, L; Randell, T; Yli-Hankala, A, 1992) |
| "The influence of anesthesia on endotoxin shock patterns in the rat was examined." | 1.27 | Anesthetic-induced changes in cardiovascular and small intestinal responses to endotoxin in the rat. ( Brackett, DJ; Schaefer, CF; Tompkins, P; Wilson, MF, 1984) |
| "Therefore, data obtained from septic shock studies applying pentobarbital have to be evaluated carefully." | 1.27 | Comparison of ketamine and pentobarbital anesthesia with the conscious state in a porcine model of Pseudomonas aeruginosa septicemia. ( Blümel, G; Pfeiffer, UJ; Worek, FS; Zeravik, J; Zimmermann, GJ, 1988) |
| "Ketamine was found to raise the systemic arterial blood pressure but not necessarily the perfusion in hypovolaemic states." | 1.25 | The cardiovascular effects of ketamine in hypotensive states. ( Jenkins, LC; Wong, DH, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 5 (20.83) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cong, N | 1 |
| Tian, T | 1 |
| Hu, B | 1 |
| Xue, FS | 1 |
| Hasanin, A | 2 |
| Fathy, S | 2 |
| Mostafa, M | 1 |
| Ramzy, E | 1 |
| Sarhan, K | 1 |
| Almenesey, T | 1 |
| Safina, AG | 1 |
| Hosny, O | 1 |
| Hamden, GA | 1 |
| Gado, AA | 1 |
| Mokhtar, A | 1 |
| Cardinale, M | 1 |
| Mathais, Q | 1 |
| Nguyen, C | 1 |
| Bordes, J | 1 |
| Meaudre, E | 1 |
| Reese, JM | 1 |
| Sullivan, VF | 1 |
| Boyer, NL | 1 |
| Mount, CA | 1 |
| Barbi, E | 1 |
| Rizzello, E | 1 |
| Taddio, A | 1 |
| Zhang, L | 2 |
| Xiao, H | 2 |
| Liu, B | 1 |
| Wang, Q | 1 |
| Taniguchi, T | 4 |
| Kanakura, H | 3 |
| Takemoto, Y | 3 |
| Kidani, Y | 2 |
| Yamamoto, K | 4 |
| Song, XM | 1 |
| Li, JG | 1 |
| Wang, YL | 1 |
| Zhou, Q | 1 |
| Du, ZH | 1 |
| Jia, BH | 1 |
| Hu, ZF | 1 |
| Li, P | 1 |
| Xu, HW | 1 |
| Liu, H | 1 |
| Ray, DC | 1 |
| McKeown, DW | 1 |
| Schaefer, CF | 1 |
| Brackett, DJ | 1 |
| Tompkins, P | 1 |
| Wilson, MF | 1 |
| Clark, RB | 1 |
| White, FA | 1 |
| Koga, K | 1 |
| Ogata, M | 1 |
| Takenaka, I | 1 |
| Matsumoto, T | 1 |
| Shigematsu, A | 1 |
| Lüebbe, AS | 1 |
| Harris, PD | 1 |
| Garrison, RN | 1 |
| Shibata, K | 1 |
| Wong, DH | 1 |
| Jenkins, LC | 1 |
| Yli-Hankala, A | 1 |
| Kirvelä, M | 1 |
| Randell, T | 1 |
| Lindgren, L | 1 |
| Van der Linden, P | 2 |
| Gilbart, E | 2 |
| Engelman, E | 2 |
| de Rood, M | 2 |
| Vincent, JL | 2 |
| Schmartz, D | 1 |
| Modig, J | 1 |
| Worek, FS | 1 |
| Blümel, G | 1 |
| Zeravik, J | 1 |
| Zimmermann, GJ | 1 |
| Pfeiffer, UJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients: a Randomized Controlled Trial[NCT03844984] | Phase 3 | 43 participants (Actual) | Interventional | 2019-02-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketamine and Endotoxin Shock
| Article | Year |
|---|---|
Advance in anesthesiology.
Topics: Abortion, Septic; Adult; Anesthesia, General; Anesthesia, Local; Anesthesia, Obstetrical; Anesthesio | 1981 |
1 trial available for ketamine and Endotoxin Shock
| Article | Year |
|---|---|
The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial.
Topics: Adult; Anesthesia, General; Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Shock, Septic | 2021 |
22 other studies available for ketamine and Endotoxin Shock
| Article | Year |
|---|---|
Is addition of lidocaine to ketamine beneficial for rapid sequence endotracheal intubation in patients with septic shock?
Topics: Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Rapid Sequence Induction and Intubation; Sho | 2022 |
In response: Was ketamine-lidocaine an adequate hypnotic agent in patients with septic shock?
Topics: Anesthetics, Local; Humans; Hypnotics and Sedatives; Ketamine; Lidocaine; Shock, Septic | 2022 |
Reply to: The benefit of adding lidocaine to ketamine during rapid sequence endotracheal intubation in patients with septic shock: A randomised controlled trial.
Topics: Humans; Intubation, Intratracheal; Ketamine; Lidocaine; Rapid Sequence Induction and Intubation; Sho | 2021 |
A Non-Comparative Prospective Pilot Study of Ketamine for Sedation in Adult Septic Shock.
Topics: Aged; Aged, 80 and over; APACHE; Female; Humans; Hypnotics and Sedatives; Intensive Care Units; Keta | 2018 |
Use of ketamine continuous infusion for pediatric sedation in septic shock.
Topics: Anesthetics, Dissociative; Child; Conscious Sedation; Humans; Infusions, Intravenous; Ketamine; Male | 2010 |
[The effect of ketamine on the expression of HSP70 induced by endotoxin in liver of rat].
Topics: Animals; Endotoxins; Escherichia coli; Female; HSP70 Heat-Shock Proteins; Ketamine; Liver; Male; Ran | 2001 |
Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats.
Topics: Anesthetics, Dissociative; Animals; Disease Models, Animal; Endotoxins; Hemodynamics; Hypnotics and | 2003 |
The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats.
Topics: Animals; Blood Gas Analysis; Body Temperature; Cytokines; Dose-Response Relationship, Drug; Hemodyna | 2003 |
The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia.
Topics: Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Te | 2004 |
[Protective effect of ketamine against septic shock in rats].
Topics: Analgesics; Animals; Disease Models, Animal; Hemodynamics; Interleukin-6; Ketamine; Male; Random All | 2004 |
[Effect of ketamine on endotoxin-induced septic shock in rats and its mechanism].
Topics: Anesthetics, Dissociative; Animals; Cyclic AMP; Disease Models, Animal; Female; HSP70 Heat-Shock Pro | 2007 |
Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock.
Topics: Aged; Anesthetics, Intravenous; Etomidate; Female; Fentanyl; Humans; Intensive Care Units; Ketamine; | 2007 |
Anesthetic-induced changes in cardiovascular and small intestinal responses to endotoxin in the rat.
Topics: Anesthesia; Animals; Blood; Blood Glucose; Blood Pressure; Carbon Dioxide; Enflurane; Gastrointestin | 1984 |
Ketamine suppresses tumor necrosis factor-alpha activity and mortality in carrageenan-sensitized endotoxin shock model.
Topics: Acidosis; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Carrageenan; Endotoxins; Hydrogen- | 1994 |
E. Coli bacteremia-induced changes in the skeletal muscle microcirculation vary with anesthetics.
Topics: Anesthetics; Animals; Bacteremia; Chloralose; Decerebrate State; Disease Models, Animal; Escherichia | 1998 |
Ketamine inhibits endotoxin-induced shock in rats.
Topics: Animals; Blood Gas Analysis; Endotoxins; Excitatory Amino Acid Antagonists; Hemodynamics; Injections | 2001 |
The cardiovascular effects of ketamine in hypotensive states.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Output; Cats; Heart Rate; Hemodynamics; Hypotension; | 1975 |
Ketamine anaesthesia in a patient with septic shock.
Topics: Aged; Anesthesia, Intravenous; Female; Humans; Ketamine; Laparotomy; Shock, Septic | 1992 |
Adrenergic support during anesthesia in experimental endotoxin shock: norepinephrine versus dobutamine.
Topics: Analysis of Variance; Anesthesia, General; Animals; Blood Gas Analysis; Dobutamine; Dogs; Drug Inter | 1991 |
Comparison of halothane, isoflurane, alfentanil, and ketamine in experimental septic shock.
Topics: Alfentanil; Animals; Dogs; Drug Evaluation, Preclinical; Escherichia coli; Halothane; Hemodynamics; | 1990 |
Positive effects of ketamine v. metomidate anesthesia on cardiovascular function, oxygen delivery and survival. Studies with a porcine endotoxin model.
Topics: Anesthesia, Intravenous; Animals; Female; Hemodynamics; Imidazoles; Ketamine; Male; Models, Biologic | 1987 |
Comparison of ketamine and pentobarbital anesthesia with the conscious state in a porcine model of Pseudomonas aeruginosa septicemia.
Topics: Anesthesia, Intravenous; Animals; Female; Hemodynamics; Ketamine; Male; Pentobarbital; Pseudomonas I | 1988 |