ketamine has been researched along with Nervous System Disorders in 24 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain." | 9.10 | Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002) |
| "Report a case of central diabetes insipidus (DI) associated with ketamine infusion." | 7.80 | Transient central diabetes insipidus induced by ketamine infusion. ( Felner, EI; Hatab, SZ; Kamat, P; Singh, A, 2014) |
| " Since sedation of animals is necessary to avoid artifacts, a mixture of ketamine and xylazine is frequently used for anesthesia." | 7.72 | Ketamine/xylazine anesthesia for radiologic imaging of neurologically impaired rats: dose response, respiratory depression, and management of complications. ( Dittmar, MS; Fehm, NP; Horn, M; Vatankhah, B, 2004) |
| "Depression is a common psychiatric symptom in numerous neurological disorders." | 6.82 | (R)-ketamine as prophylactic and therapeutic drug for neurological disorders: Beyond depression. ( Hashimoto, K; Wang, X; Yang, J, 2022) |
| "Both lidocaine an adrenaline at the scheduled doses showed low sensitivity and specificity as a simulated iv epidural test dose." | 5.20 | [Epidural anaesthesia: Simulated intravascular test dose with S(+) ketamine, lidocaine and adrenaline. A prospective, randomized, double blind and placebo controlled study]. ( Errando, CL; Higueras, R; Soriano-Bru, JL, 2015) |
| "The aim of the present study was to clarify the neurophysiological changes associated with analgesic and behavioral effects of low-dose ketamine HCl in patients suffering from chronic neuropathic pain." | 5.10 | Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study. ( Kato, J; Kojima, T; Matsuura, M; Nagashima, M; Oga, K; Ogawa, S; Saeki, S, 2002) |
| "Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist used recently for analgesia in patients with chronic pain." | 5.09 | Clinical experience with oral ketamine. ( Enarson, MC; Hays, H; Woodroffe, MA, 1999) |
| "Report a case of central diabetes insipidus (DI) associated with ketamine infusion." | 3.80 | Transient central diabetes insipidus induced by ketamine infusion. ( Felner, EI; Hatab, SZ; Kamat, P; Singh, A, 2014) |
| " Since sedation of animals is necessary to avoid artifacts, a mixture of ketamine and xylazine is frequently used for anesthesia." | 3.72 | Ketamine/xylazine anesthesia for radiologic imaging of neurologically impaired rats: dose response, respiratory depression, and management of complications. ( Dittmar, MS; Fehm, NP; Horn, M; Vatankhah, B, 2004) |
| " In cell cultures, CgTx inhibited hypoxia-induced 45Ca accumulation and neuronal injury minimally, compared to the NMDA antagonist ketamine." | 3.68 | Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury. ( Clark, WM; Madden, KP; Marcoux, FW; Probert, AW; Rivier, J; Weber, ML; Zivin, JA, 1990) |
| "Depression is a common psychiatric symptom in numerous neurological disorders." | 2.82 | (R)-ketamine as prophylactic and therapeutic drug for neurological disorders: Beyond depression. ( Hashimoto, K; Wang, X; Yang, J, 2022) |
| "Laryngospasm was observed in 6 patients without statistical difference between the 2 groups." | 2.77 | Ketamine with and without midazolam for gastrointestinal endoscopies in children. ( Brecelj, J; Orel, R; Trop, TK, 2012) |
| "Monitoring for pain, sedation, postoperative nausea/vomiting, dizziness, and pruritus was performed by anesthesiologists blinded to the study allocation." | 2.71 | Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. ( Acharya, A; Kumar, P; Pan, AK; Rudra, A, 2005) |
| " While patient safety in anaesthesia has greatly improved, the risk of neurological and psychiatric adverse effects of anaesthetics remains and is the focus of continued investigation." | 2.39 | Neurological and psychiatric adverse effects of anaesthetics: epidemiology and treatment. ( Klafta, JM; Young, CJ; Zacny, JP, 1995) |
| "Ketamine was used in most severe cases." | 1.42 | Preliminary results of the global audit of treatment of refractory status epilepticus. ( Ferlisi, M; Grade, M; Hocker, S; Shorvon, S; Trinka, E, 2015) |
| "Asystolic cardiac arrest for 8 minutes was induced in 73 rats with a mixture of potassium chloride and esmolol." | 1.42 | Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? ( Bendel, S; Grandgirard, D; Haenggi, M; Jakob, SM; Leib, SL; Pereira, A; Putzu, A; Schlickeiser, J; Springe, D; Takala, J, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.50) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Yang, J | 1 |
| Hashimoto, K | 1 |
| de Carvalho Cartágenes, S | 1 |
| Fernandes, LMP | 1 |
| Carvalheiro, TCVS | 1 |
| de Sousa, TM | 1 |
| Gomes, ARQ | 1 |
| Monteiro, MC | 1 |
| de Oliveira Paraense, RS | 1 |
| Crespo-López, ME | 1 |
| Lima, RR | 1 |
| Fontes-Júnior, EA | 1 |
| Prediger, RD | 1 |
| Maia, CSF | 1 |
| Higueras, R | 1 |
| Errando, CL | 1 |
| Soriano-Bru, JL | 1 |
| Hatab, SZ | 1 |
| Singh, A | 1 |
| Felner, EI | 1 |
| Kamat, P | 1 |
| Ferlisi, M | 1 |
| Hocker, S | 1 |
| Grade, M | 1 |
| Trinka, E | 1 |
| Shorvon, S | 1 |
| Bendel, S | 1 |
| Springe, D | 1 |
| Pereira, A | 1 |
| Grandgirard, D | 1 |
| Leib, SL | 1 |
| Putzu, A | 1 |
| Schlickeiser, J | 1 |
| Jakob, SM | 1 |
| Takala, J | 1 |
| Haenggi, M | 1 |
| Patel, P | 1 |
| Sun, L | 1 |
| Brecelj, J | 1 |
| Trop, TK | 1 |
| Orel, R | 1 |
| Oga, K | 1 |
| Kojima, T | 1 |
| Matsuura, M | 1 |
| Nagashima, M | 1 |
| Kato, J | 1 |
| Saeki, S | 1 |
| Ogawa, S | 1 |
| Fredriksson, A | 1 |
| Archer, T | 1 |
| Dittmar, MS | 1 |
| Fehm, NP | 1 |
| Vatankhah, B | 1 |
| Horn, M | 1 |
| Kumar, P | 1 |
| Rudra, A | 1 |
| Pan, AK | 1 |
| Acharya, A | 1 |
| Himmelseher, S | 1 |
| Durieux, ME | 1 |
| Smith, FJ | 1 |
| Bartel, PR | 1 |
| Hugo, JM | 1 |
| Becker, PJ | 1 |
| Klafta, JM | 1 |
| Zacny, JP | 1 |
| Young, CJ | 1 |
| Enarson, MC | 1 |
| Hays, H | 1 |
| Woodroffe, MA | 1 |
| Sang, CN | 1 |
| McDowall, DG | 1 |
| Akeson, J | 1 |
| Berntman, L | 1 |
| Messeter, K | 1 |
| Earley, B | 1 |
| Burke, M | 1 |
| Leonard, BE | 1 |
| Gouret, CJ | 1 |
| Junien, JL | 1 |
| Takadera, T | 1 |
| Suzuki, R | 1 |
| Mohri, T | 1 |
| Madden, KP | 1 |
| Clark, WM | 1 |
| Marcoux, FW | 1 |
| Probert, AW | 1 |
| Weber, ML | 1 |
| Rivier, J | 1 |
| Zivin, JA | 1 |
| Malinovsky, JM | 1 |
| Mussini, JM | 1 |
| Cozian, A | 1 |
| Lepage, JY | 1 |
| Cavaillé, P | 1 |
| Pinaud, M | 1 |
| de Dieuleveult, C | 1 |
| Souron, R | 1 |
| Rapkin, RH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759] | Phase 1 | 240 participants (Anticipated) | Interventional | 2021-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for ketamine and Nervous System Disorders
| Article | Year |
|---|---|
(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: Beyond depression.
Topics: Antidepressive Agents; Dementia; Depression; Humans; Ketamine; Nervous System Diseases; Stroke | 2022 |
Revising a dogma: ketamine for patients with neurological injury?
Topics: Anesthetics, Dissociative; Cerebrovascular Circulation; Critical Care; Excitatory Amino Acid Antagon | 2005 |
Neurological and psychiatric adverse effects of anaesthetics: epidemiology and treatment.
Topics: Anesthetics; Droperidol; Humans; Ketamine; Nervous System Diseases; Risk Factors | 1995 |
NMDA-receptor antagonists in neuropathic pain: experimental methods to clinical trials.
Topics: Analgesics; Clinical Trials as Topic; Dextromethorphan; Excitatory Amino Acid Antagonists; Humans; K | 2000 |
Neurosurgical anaesthesia and intensive care.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia; Brain; Carbon Dioxide; Cerebrovascular Circulation; Criti | 1978 |
6 trials available for ketamine and Nervous System Disorders
| Article | Year |
|---|---|
[Epidural anaesthesia: Simulated intravascular test dose with S(+) ketamine, lidocaine and adrenaline. A prospective, randomized, double blind and placebo controlled study].
Topics: Adult; Anesthesia, Epidural; Double-Blind Method; Elective Surgical Procedures; Epinephrine; Female; | 2015 |
Ketamine with and without midazolam for gastrointestinal endoscopies in children.
Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; Drug Administrat | 2012 |
Effects of low-dose ketamine on neuropathic pain: An electroencephalogram-electrooculogram/behavioral study.
Topics: Aged; Anesthetics, Dissociative; Electroencephalography; Female; Hallucinations; Humans; Injections, | 2002 |
Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine.
Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anest | 2005 |
Anesthetic technique (sufentanil versus ketamine plus midazolam) and quantitative electroencephalographic changes after cardiac surgery.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Anesthetics, Combined; Anesthetics, Dissociative; An | 2006 |
Clinical experience with oral ketamine.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Chronic Disease; Female; Humans; K | 1999 |
13 other studies available for ketamine and Nervous System Disorders
| Article | Year |
|---|---|
"Special K" Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments.
Topics: Animals; Female; Ketamine; Nervous System Diseases; Oxidative Stress; Rats; Rats, Wistar | 2019 |
Transient central diabetes insipidus induced by ketamine infusion.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Anesthetics; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Child | 2014 |
Preliminary results of the global audit of treatment of refractory status epilepticus.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Dissociat | 2015 |
Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model?
Topics: Anesthetics; Animals; Apoptosis; Fentanyl; Heart Arrest; Hippocampus; Ketamine; Male; Medetomidine; | 2015 |
Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans.
Topics: Age Factors; Anesthesia; Anesthetics, General; Animals; Apoptosis; Cell Death; Humans; Infant, Newbo | 2009 |
Neurobehavioural deficits associated with apoptotic neurodegeneration and vulnerability for ADHD.
Topics: Animals; Animals, Newborn; Apoptosis; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2004 |
Ketamine/xylazine anesthesia for radiologic imaging of neurologically impaired rats: dose response, respiratory depression, and management of complications.
Topics: Anesthesia; Anesthetics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Infarcti | 2004 |
Cerebral haemodynamic and metabolic effects of hypnotics and analgesics.
Topics: Analgesics; Brain; Cerebrovascular Circulation; Humans; Hypnotics and Sedatives; Ketamine; Nervous S | 1992 |
A comparison of the psychopharmacological profiles of phencyclidine, ketamine and (+) SKF 10,047 in the trimethyltin rat model.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Ketamine; Learning; Male; Nervous Sy | 1990 |
Protection by ethanol of cortical neurons from N-methyl-D-aspartate-induced neurotoxicity is associated with blocking calcium influx.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultu | 1990 |
Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypoxia; Injections; Ischemia; Ketamine | 1990 |
[Neurotoxicity of ketamine and midazolam by intrathecal injection in the rabbit].
Topics: Animals; Injections, Spinal; Ketamine; Midazolam; Nervous System Diseases; Rabbits | 1989 |
Ketamine in neuroradiology.
Topics: Anesthetics; Cyclohexanes; Humans; Ketamine; Nervous System Diseases | 1971 |