Page last updated: 2024-09-28

Gargoylism, Hunter Syndrome

Synonyms(11)

Synonym
Hunter Syndrome Gargoylism
I2S Deficiency
Gargoylism, Hunter Syndrome
Mucopolysaccharidosis Type 2
Iduronate 2-Sulfatase Deficiency
Mucopolysaccharidosis Type II
Hunter Syndrome
Iduronate Sulfatase Deficiency
Hunter's Syndrome
Mucopolysaccharidosis 2
Sulfoiduronate Sulfatase Deficiency

Research Excerpts

Overview

ExcerptReference
"Hunter syndrome is one of a heterogeneous group of recessively inherited mucopolysaccharide storage diseases (MPS) with similar biochemical defects manifested by impairments in mucopolysaccharide catabolism with variable but progressive clinical courses."( Barst, S; Boorin, MR; Crespi, P; Kreidstein, A; Lebowitz, P, 1994)
"Hunter syndrome (Mucopolysaccharidosis type II) is a rare X-linked recessive lysosomal storage disorder caused by the deficiency of the enzyme iduronate-2-sulfatase (IDS)."( Corsolini, F; Di Duca, M; Filocamo, M; Gatti, R; Regis, S; Ricci, V; Stroppiano, M, 2003)
"Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of the primary storage substrate, glycosaminoglycans (GAGs)."( Arguello, A; Astarita, G; Bhalla, A; Blumenfeld, JR; Cahan, H; Chiu, CL; Davis, SS; Diaz, D; Earr, TK; Escolar, ML; Fang, M; Fiore, D; Harris, JM; Nguyen, HN; Ravi, R; Scearce-Levie, K; Troyer, MD; Wang, J; Zhu, Y, 2020)

Context

ExcerptReference
"Hunter syndrome has a wide variance of clinical phenotypes ranging from mild to severe."( Barst, S; Boorin, MR; Crespi, P; Kreidstein, A; Lebowitz, P, 1994)

Treatment

ExcerptReference
"Neurological involvement in X-linked mucopolysaccharidosis type II (Hunter syndrome) is indicative of more severe disease, but is not attenuated by current enzyme replacement therapy which does not significantly penetrate the blood-brain barrier."( Davies, NP; Davison, JE; Gissen, P; Hendriksz, CJ; Peet, AC; Sun, Y, 2010)

Research

Studies (147)

TimeframeStudies, This Condition (%)All Conditions %
pre-199055 (37.41)23.3326
1990's8 (5.44)12.5806
2000's16 (10.88)18.1394
2010's49 (33.33)28.8240
2020's19 (12.93)9.53
DrugIndicatedRelationship StrengthStudiesTrials
choline0low10
salicylic acid0low10
lactic acid0low10
glycine0low10
inositol0low10
nitrous oxide0low10
baclofen0low10
cetylpyridinium0low10
chloroquine0low10
chlorpromazine0low10
enflurane0low10
ethosuximide0low10
fentanyl0low10
hydroxychloroquine0low10
2-propanol0low20
ketamine0low10
meperidine0low10
midazolam0low10
pamidronate0low10
promethazine0low10
propofol0low30
sevoflurane0low10
thalidomide0low10
prednisolone0low10
alanine0low20
aspartic acid0low10
galactose0low20
lactose0low10
threonine0low10
arginine0low10
catechin0low10
malondialdehyde0low20
durapatite0low10
d-alpha tocopherol0low10
tocopherols0low10
fucose0low20
fluorescein-5-isothiocyanate0low10
mannose0low20
neodymium0low10
technetium0low10
acetylglucosamine0low10
galactosamine0low50
glutamic acid0low10
acetylgalactosamine0low10
acridine orange0low10
glucose, (beta-d)-isomer0low10
n-acetylaspartic acid0low10
fructose-1-phosphate0low30
tyloxapol0low10
4-methylumbelliferyl sulfate0low10
delta-tocopherol0low10
pyridinoline0low10
deoxypyridinoline0low10
kifunensine0low10
torcetrapib0low10
angiotensin ii0low10
iduronate 2-sulfate0low30
glycogen0low20
n-acetylneuraminic acid0low10
mannose-6-phosphate0low30
glucosamine0low80
epiglucan0low10
ouabain0low10
iduronate0low190
c(alpha)-formylglycine0low10
retinol0low10
keratan sulfate0low20
bromochloroacetic acid0low10
glycosides0low10
pica0low10
dermatan sulfate0medium281
hymecromone0low30
kaempferol0low10
genistein0low60
daidzein0low20
coenzyme q100low10
naloxone0low10
dexmedetomidine0low10
sulfur0low10
cysteine0low10
ammonium sulfate0low10
i(3)so3-galactosylceramide0low20
g(m2) ganglioside0low10
acid phosphatase0low10
jaw0low10
oligonucleotides0low20
vendex0low10
sodium ethylxanthate0low10
glycolipids0low40
chondroitin0low130
heparitin sulfate0low270
phytoestrogens0low10
g(m3) ganglioside0low10
hyaluronoglucosaminidase0low50
chondroitin sulfates0medium61
eye0low20

Protein Targets (899)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma150015
GLI family zinc finger 3140014
AR protein230023
aldehyde dehydrogenase 1 family, member A1120012
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha110011
estrogen nuclear receptor alpha210021
peroxisome proliferator-activated receptor delta100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
activating transcription factor 6110011
v-jun sarcoma virus 17 oncogene homolog (avian)8008
Histone H2A.x9009
thyroid hormone receptor beta isoform a4004
heat shock protein beta-19009
nuclear factor erythroid 2-related factor 2 isoform 1120012
lamin isoform A-delta10180018
Voltage-dependent calcium channel gamma-2 subunit5005
Glutamate receptor 25218
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Fibrinogen C domain-containing protein 10101
Putative glycosyltransferase WbgO0001
Cytochrome P450 3A40304
Cannabinoid receptor 10101
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Telomerase reverse transcriptase0101
Amyloid-beta precursor protein0505
Reverse transcriptase/RNaseH 0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Carbonic anhydrase 107011
Carbonic anhydrase 207011
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 09212
Proton-coupled amino acid transporter 10202
Adenosine deaminase0001
Carbonic anhydrase 40002
glucocerebrosidase5005
DNA polymerase kappa isoform 18008
histone acetyltransferase KAT2A isoform 17007
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase150015
phosphopantetheinyl transferase9009
NFKB1 protein, partial4004
GLS protein9009
thyroid stimulating hormone receptor5005
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 2190019
cytochrome P450 2C19 precursor6006
chromobox protein homolog 18008
flap endonuclease 17007
DNA polymerase iota isoform a (long)7007
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)5005
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase8008
Chain A, Ferritin light chain5005
arylsulfatase A6006
Bloom syndrome protein isoform 18008
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 08211
Glutamate receptor ionotropic, NMDA 2B08211
Glutamate receptor ionotropic, NMDA 2C08211
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D08211
Glutamate receptor ionotropic, NMDA 3B08211
Glutamate receptor ionotropic, NMDA 3A08211
ATAD5 protein, partial6006
regulator of G-protein signaling 44004
67.9K protein6006
D(1A) dopamine receptor4004
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi82111
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Gamma-aminobutyric acid type B receptor subunit 20213
Gamma-aminobutyric acid type B receptor subunit 20202
Bile salt export pump013013
Gamma-aminobutyric acid receptor subunit beta-182111
Gamma-aminobutyric acid receptor subunit delta82111
Gamma-aminobutyric acid receptor subunit gamma-282212
Gamma-aminobutyric acid receptor subunit alpha-582111
Gamma-aminobutyric acid receptor subunit alpha-382111
Gamma-aminobutyric acid receptor subunit gamma-182111
Gamma-aminobutyric acid receptor subunit alpha-282111
Gamma-aminobutyric acid receptor subunit alpha-482111
Gamma-aminobutyric acid receptor subunit gamma-382111
Gamma-aminobutyric acid receptor subunit alpha-682111
Gamma-aminobutyric acid receptor subunit alpha-182212
Gamma-aminobutyric acid receptor subunit beta-382111
Gamma-aminobutyric acid receptor subunit beta-282212
GABA theta subunit82111
Canalicular multispecific organic anion transporter 10909
Gamma-aminobutyric acid receptor subunit epsilon82111
Gamma-aminobutyric acid type B receptor subunit 10213
Gamma-aminobutyric acid type B receptor subunit 10101
nuclear receptor subfamily 1, group I, member 39009
thyroid stimulating hormone receptor6006
Cellular tumor antigen p53150015
Nuclear receptor ROR-gamma4004
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, 2-oxoglutarate Oxygenase6006
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Microtubule-associated protein tau7007
peripheral myelin protein 22 isoform 14004
DNA polymerase beta2002
DNA polymerase eta isoform 13003
survival motor neuron protein isoform d6006
neuropeptide S receptor isoform A2002
Prostaglandin G/H synthase 1 0101
Arginase 0303
Pancreatic triacylglycerol lipase0303
Prothrombin0123
Prostaglandin G/H synthase 10112
Aldo-keto reductase family 1 member B10909
Carbonic anhydrase 40405
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60203
Sucrase-isomaltase, intestinal0101
Adenosine receptor A10102
Adenosine receptor A2a0203
Prostaglandin G/H synthase 20404
Mu-type opioid receptor07312
Delta-type opioid receptor07110
Kappa-type opioid receptor07211
Xanthine dehydrogenase/oxidase0404
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10303
Beta-secretase 10202
Prostaglandin G/H synthase 20202
Carbonic anhydrase 30101
Dihydroorotate dehydrogenase 0202
TDP1 protein140014
Smad32002
interferon gamma precursor0001
Alpha-synuclein1102
PPM1D protein3003
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
Spike glycoprotein0347
Replicase polyprotein 1ab0347
glucose-6-phosphate 1-dehydrogenase isoform b0101
Transmembrane protease serine 20347
Dihydrofolate reductase 0101
DNA ligase0101
Interferon beta9009
Riboflavin-binding protein0011
Major prion protein0033
Histidine-rich protein PFHRP-II0102
Procathepsin L0347
Muscarinic acetylcholine receptor M20707
Muscarinic acetylcholine receptor M40606
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0718
Replicase polyprotein 1a0347
Replicase polyprotein 1ab0347
Replicase polyprotein 1ab0549
Spike glycoprotein0101
Replicase polyprotein 1ab0549
Muscarinic acetylcholine receptor M10606
Ribosyldihydronicotinamide dehydrogenase [quinone]0101
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0718
DNA ligase 10101
Muscarinic acetylcholine receptor M30606
Serine/threonine-protein kinase mTOR0101
Nuclear receptor subfamily 4 group A member 20011
Spike glycoprotein63413
Calcium-dependent protein kinase 10011
MO15-related protein kinase Pfmrk 0202
DNA ligase A0101
Potassium voltage-gated channel subfamily H member 20808
Sigma intracellular receptor 20202
Phosphoethanolamine N-methyltransferase0101
Ataxin-27007
Sigma non-opioid intracellular receptor 10909
Angiotensin-converting enzyme 2 0347
Cysteine proteinase falcipain 2a 0101
Cysteine proteinase falcipain 2a 0101
Proteasome subunit beta type-110001
acetylcholinesterase7007
Fumarate hydratase1001
USP1 protein, partial6006
Thrombopoietin3003
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)110011
progesterone receptor110011
NADPH oxidase 10101
cytochrome P450 family 3 subfamily A polypeptide 4120012
glucocorticoid receptor [Homo sapiens]120012
estrogen-related nuclear receptor alpha180018
farnesoid X nuclear receptor9009
pregnane X nuclear receptor120012
G6006
cytochrome P450 2D66006
polyprotein1001
peroxisome proliferator activated receptor gamma8008
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
Snq2p0002
caspase-33003
IDH12002
Adenylate cyclase type 1 0202
Caspase-72002
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a6006
vitamin D3 receptor isoform VDRA4004
potassium voltage-gated channel subfamily H member 2 isoform d5005
caspase-32002
thyroid hormone receptor beta isoform 29009
histone deacetylase 9 isoform 34004
mitogen-activated protein kinase 13003
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A4004
serine/threonine-protein kinase mTOR isoform 12002
geminin140014
peripheral myelin protein 22100010
M-phase phosphoprotein 84004
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0506
Polyunsaturated fatty acid lipoxygenase ALOX15B2103
Glutamate receptor ionotropic, NMDA 2D0303
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0303
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Bile salt export pump0202
5-hydroxytryptamine receptor 40808
Potassium channel subfamily K member 20101
Epidermal growth factor receptor0303
HLA class I histocompatibility antigen, B alpha chain 6006
Albumin0112
Albumin0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Major prion protein0011
Integrin beta-35016
Cytochrome P450 1A20112
Tyrosine-protein kinase Fyn0303
ATP-dependent translocase ABCB10326
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Integrin alpha-IIb5016
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50202
Cys-loop ligand-gated ion channel0101
Calmodulin-10314
Cytochrome P450 2D60213
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C9 0404
Polyunsaturated fatty acid lipoxygenase ALOX150505
Angiotensin-converting enzyme0202
D(2) dopamine receptor0506
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0303
Sphingomyelin phosphodiesterase0101
D0202
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0303
D(2) dopamine receptor0101
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0405
D(4) dopamine receptor0304
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40103
Alpha-2A adrenergic receptor0303
Alpha-1D adrenergic receptor0303
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter0303
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0707
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50304
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0808
5-hydroxytryptamine receptor 1B0404
Trypanothione reductase0404
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0101
Histamine H1 receptor0112
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0204
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0505
D(3) dopamine receptor0506
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
5-hydroxytryptamine receptor 2B0606
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0303
Histamine H2 receptor6006
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
5-hydroxytryptamine receptor 70202
Cytochrome P450 2J20303
Gastrin/cholecystokinin type B receptor0101
Proteasome subunit alpha type-60012
D(2) dopamine receptor0203
Calmodulin 0123
Aldehyde oxidase 10101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0404
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10404
Aldehyde oxidase0303
Glutamate receptor ionotropic, NMDA 2A0404
Glutamate receptor ionotropic, NMDA 2B0404
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0303
Sodium channel protein type 9 subunit alpha0101
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0303
Inositol hexakisphosphate kinase 16006
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial6006
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20001
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0303
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10102
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20102
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
importin subunit beta-1 isoform 14004
snurportin-14004
GTP-binding nuclear protein Ran isoform 11001
Rap guanine nucleotide exchange factor 32002
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Luciferase6006
EWS/FLI fusion protein9009
Neuraminidase 0404
Parkin2002
pyruvate kinase3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
aryl hydrocarbon receptor4004
NPC intracellular cholesterol transporter 1 precursor3003
cytochrome P450 2C9 precursor5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
rac GTPase-activating protein 1 isoform a0202
pyruvate kinase PKM isoform b2002
Carbonic anhydrase 120405
Aldo-keto reductase family 1 member B100101
Transthyretin0202
Estrogen receptor0617
Glucocorticoid receptor02111
Aldehyde dehydrogenase, mitochondrial0101
Ornithine decarboxylase2002
Androgen receptor0407
Tyrosinase0202
Aromatase0202
Urease subunit alpha0101
Aldo-keto reductase family 1 member B10505
Polyunsaturated fatty acid lipoxygenase ALOX150101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Amine oxidase [flavin-containing] A0303
UDP-glucuronosyltransferase 1A1 0303
Amine oxidase [flavin-containing] B0404
Substance-P receptor0303
Carbonic anhydrase 70304
Estrogen receptor0011
Urease subunit beta0101
Inositol monophosphatase 13003
Transporter0101
Substance-K receptor0303
Estrogen receptor beta0617
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0202
ATPase family AAA domain-containing protein 54004
Prenyltransferase homolog0002
Estrogen receptor beta0011
Alpha-1B adrenergic receptor 0011
Alpha-1A adrenergic receptor0011
nuclear receptor ROR-gamma isoform 13003
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Nuclear receptor subfamily 1 group I member 20011
Delta-type opioid receptor0517
Delta-type opioid receptor0426
Mu-type opioid receptor0437
Kappa-type opioid receptor0224
Kappa-type opioid receptor0415
Mu-type opioid receptor0304
Mu-type opioid receptor0516
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10202
thyrotropin-releasing hormone receptor1001
Fucose-binding lectin PA-IIL0202
CD209 antigen0303
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Transthyretin0011
Chain A, Transthyretin0011
acid sphingomyelinase1001
glp-1 receptor, partial2002
BRCA11001
15-lipoxygenase, partial4004
SMAD family member 25005
SMAD family member 35005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
P531001
Alpha-mannosidase0101
hexokinase-4 isoform 12002
glucokinase regulatory protein2002
glycogen synthase kinase-3 beta isoform 10022
tyrosine-protein kinase Yes1001
Maltase-glucoamylase, intestinal0202
Steroid hormone receptor ERR20101
Tyrosine-protein kinase ABL10101
Triosephosphate isomerase0101
Sex hormone-binding globulin0011
Cyclin-dependent kinase 10202
Sialidase0202
Solute carrier family 2, facilitated glucose transporter member 10202
Steroid hormone receptor ERR10202
Cyclin-dependent kinase 40101
Ornithine decarboxylase0101
Proto-oncogene tyrosine-protein kinase Src0101
Cystic fibrosis transmembrane conductance regulator0011
17-beta-hydroxysteroid dehydrogenase type 10202
Solute carrier family 2, facilitated glucose transporter member 40101
G2/mitotic-specific cyclin-B10202
Dipeptidyl peptidase 40101
Androgen receptor0202
Protein kinase C alpha type0101
cAMP-dependent protein kinase catalytic subunit alpha0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A 0101
G1/S-specific cyclin-D10101
Thromboxane-A synthase 0101
Cruzipain0101
DNA (cytosine-5)-methyltransferase 10101
Dipeptidyl peptidase 40202
Adenosine receptor A2a0202
Adenosine receptor A10303
Sodium-dependent serotonin transporter0202
RAC-alpha serine/threonine-protein kinase0101
Cystic fibrosis transmembrane conductance regulator0011
Testosterone 17-beta-dehydrogenase 30202
17-beta-hydroxysteroid dehydrogenase type 20202
Acetylcholinesterase0101
Alpha-glucosidase MAL320101
Signal transducer and activator of transcription 30101
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ABL20101
Tyrosine-protein kinase SYK0101
Dual specificity mitogen-activated protein kinase kinase 40101
Quinone oxidoreductase0001
Cytoplasmic tyrosine-protein kinase BMX0101
Mitogen-activated protein kinase 100202
Oxysterols receptor LXR-beta0101
Amine oxidase [flavin-containing] B0101
Xanthine dehydrogenase/oxidase0202
Oxysterols receptor LXR-alpha0101
Mitogen-activated protein kinase 140202
Tissue alpha-L-fucosidase0101
Integrase 0202
Carboxylic ester hydrolase 0101
Solute carrier organic anion transporter family member 1B30202
Dipeptidyl peptidase 30202
DNA (cytosine-5)-methyltransferase 3-like0101
Sialidase-20303
DNA (cytosine-5)-methyltransferase 3A0101
Solute carrier organic anion transporter family member 1B10202
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Genome polyprotein 0101
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
GALC protein1001
lysosomal alpha-glucosidase preproprotein1001
caspase-1 isoform alpha precursor1001
Acetylcholinesterase0202
Nuclear factor NF-kappa-B p105 subunit0101
Genome polyprotein0101
Caspase-71001
Small conductance calcium-activated potassium channel protein 30101
Cholinesterase0202
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Carbonic anhydrase 90203
Oleandomycin glycosyltransferase0001
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
TAR DNA-binding protein 431001
Sodium/myo-inositol cotransporter 20101
Chymotrypsinogen A0101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, Cruzipain2002
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain B, Transthyretin0011
Chain A, Transthyretin0011
Chain B, Transthyretin0011
apical membrane antigen 1, AMA12002
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Polyphenol oxidase 20204
G2/mitotic-specific cyclin-B20101
Cationic trypsin0101
Protein E60101
Neuraminidase0101
Interstitial collagenase0101
Cytochrome P450 1A10202
Myeloperoxidase0101
Tyrosine-protein kinase Yes0101
Beta-glucuronidase0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Serine/threonine-protein kinase pim-10101
Tyrosinase0202
G2/mitotic-specific cyclin-B0101
Glycogen synthase kinase-3 beta0101
Casein kinase II subunit alpha'0101
ATP-dependent translocase ABCB10112
Multidrug resistance-associated protein 1 0101
Aryl hydrocarbon receptor0101
Receptor-type tyrosine-protein kinase FLT30101
Prolyl endopeptidase0101
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
E3 ubiquitin-protein ligase XIAP0101
Cyclin-dependent kinase 60101
Cyclin-dependent-like kinase 5 0101
Cyclin homolog0101
Lactoylglutathione lyase0101
Cyclin-dependent kinase 5 activator 10101
Cytochrome P450 1B10202
Casein kinase II subunit alpha 30101
Inositol polyphosphate multikinase0101
Histone-lysine N-methyltransferase SETD70101
G2/mitotic-specific cyclin-B30101
Enoyl-acyl-carrier protein reductase 0101
3-oxoacyl-acyl-carrier protein reductase 0101
Aurora kinase B0101
Cyclin-dependent kinase 10101
NADPH oxidase 40101
CDGSH iron-sulfur domain-containing protein 10202
Inositol hexakisphosphate kinase 20101
Short transient receptor potential channel 50101
Chain A, ALPHA1,2-MANNOSIDASE0101
Chain A, ALPHA1,2-MANNOSIDASE0101
Chain A, Alpha-mannosidase II0101
Chain A, PUTATIVE ALPHA-1,2-MANNOSIDASE0101
Chain A, Putative Alpha-1,2-mannosidase0101
Chain B, Alpha-1,2-mannosidase0101
Chain A, PUTATIVE ALPHA-1,2-MANNOSIDASE0101
Alpha-1,2-mannosidase family protein0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Glycoside hydrolase family 920101
Glycoside hydrolase family 920101
Alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase family protein0101
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, cellulase0011
Chain A, cellulase0011
Chain A, Galectin-30011
Chain A, Anti-tumor lectin0101
Galectin-30101
Galectin-90011
Galectin-80011
Beta-galactoside-binding lectin0101
Galectin-10113
Galectin-30112
Galectin-30113
Galectin-70011
Alpha 1,4 galactosyltransferase0001
dopamine D1 receptor1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Carbonic anhydrase 30102
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase0001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
phosphoglycerate kinase1001
transcriptional regulator ERG isoform 32002
Alpha-mannosidase 2C10101
Liver carboxylesterase 10001
Kappa-type opioid receptor0203
ATP-dependent translocase ABCB10101
Translocator protein0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 2B10 0101
nuclear factor erythroid 2-related factor 2 isoform 22002
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Rap guanine nucleotide exchange factor 41001
Sialidase-40101
Sialidase-10101
Sialidase-30101
Histidine decarboxylase0011
Beta-2 adrenergic receptor0101
UDP-glucuronosyltransferase 1A80002
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)0101
Chain L, Igg2b-kappa 40-50 Fab (light Chain)0101
Chain A, Beta-lactamase1001
Chain A, Na, K-ATPase alpha subunit0011
STAT3, partial0101
Kruppel-like factor 50101
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Sodium/potassium-transporting ATPase subunit alpha-1 0203
Sodium/potassium-transporting ATPase subunit beta-10203
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Sodium/potassium-transporting ATPase subunit alpha-30102
Sodium/potassium-transporting ATPase subunit beta-20102
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Sodium/potassium-transporting ATPase subunit alpha-20203
Sodium/potassium-transporting ATPase subunit beta-30102
Sodium/potassium-transporting ATPase subunit gamma0102
Sodium/potassium-transporting ATPase subunit alpha-40102
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Geranylgeranyl pyrophosphate synthase0101
Farnesyl pyrophosphate synthase0202
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0101
luciferase0001
nuclear receptor subfamily 1, group I, member 21001
Fatty acid-binding protein, liver0101
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Nociceptin receptor0011
huntingtin isoform 21001
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Chloroquine resistance transporter0101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit alpha-60011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
interleukin 81001
pregnane X receptor1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Cholesteryl ester transfer protein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]