ketamine has been researched along with Complex Regional Pain Syndrome in 57 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is a narrative review of intravenous ketamine infusions for the treatment of complex regional pain syndrome (CRPS)." | 9.41 | Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response. ( Lii, TR; Singh, V, 2023) |
| "A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS)." | 9.14 | Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine. ( Drummond, PD; Finch, PM; Knudsen, L, 2009) |
| "This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients." | 9.13 | Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) |
| "This systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine." | 8.91 | A systematic review of ketamine for complex regional pain syndrome. ( Connolly, SB; Harden, RN; Prager, JP, 2015) |
| "Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response." | 8.31 | Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023) |
| "This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients." | 8.31 | Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome. ( Hong, SW; Hwang, MS; Kim, JH; Kim, M; Kim, SH, 2023) |
| " Neuropathic pain represents the first indication to use ketamine, followed, with a good to moderate utility, by other situations (fibromyalgia, complex regional pain syndrome, central neuropathic pain, peripheral neuropathic pain, nociceptive pain, sensitization, opioid withdrawal, palliative care, depression)." | 8.12 | Ketamine in chronic pain: A Delphi survey. ( Amodéo, JM; André, G; Barmaki, M; Collard, O; Colomb, C; Créac'h, C; de Chazeron, I; de Montgazon, G; Deleens, R; Delorme, C; Dixneuf, V; Dy, L; Gaillard, J; Gov, C; Kieffer, X; Lanteri-Minet, M; Le Borgne, JM; Le Caër, F; Maamar, F; Maindet, C; Marcaillou, F; Morel, V; Pickering, G; Plantevin, F; Pluchon, YM; Riant, T; Rioult, B; Rostaing, S; Salvat, E; Sep Hieng, V; Sorel, M; Vergne-Salle, P; Voute, M, 2022) |
| " Thirty-one clinics used ketamine for chronic pain treatment." | 8.12 | Ketamine therapy for chronic pain in The Netherlands: a nationwide survey. ( Bharwani, KD; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2022) |
| "The objective of this study was to assess the effectiveness of a low-dose intravenous S-ketamine treatment on refractory pain in patients with Complex Regional Pain Syndrome (CRPS)." | 8.02 | Effect of intravenous low-dose S-ketamine on pain in patients with Complex Regional Pain Syndrome: A retrospective cohort study. ( Bharwani, KD; de Vos, CC; Dirckx, M; Frankema, SPG; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2021) |
| "To find and reach a consensus on the usage of ketamine in the treatment of complex regional pain syndrome and to determine a reference protocol for future studies." | 7.91 | Intravenous Ketamine Infusion for Complex Regional Pain Syndrome: Survey, Consensus, and a Reference Protocol. ( Anderson, S; Foorsov, V; Getson, P; Harbut, RE; Harden, RN; Herndon, C; Moskovitz, P; Xu, J, 2019) |
| "To evaluate the changes in glutamate/GABA balance of intracortical excitability produced by ketamine, delivered at subanaesthetic dose to treat patients with complex regional pain syndrome (CRPS)." | 7.88 | A reappraisal of the mechanisms of action of ketamine to treat complex regional pain syndrome in the light of cortical excitability changes. ( Armessen, C; Ayache, SS; Lefaucheur, JP; Locko, B; Sorel, M; Zrek, N, 2018) |
| "Previous reports have indicated that ketamine anesthesia may produce significant improvement if not complete recovery of patients with complex regional pain syndrome (CRPS)." | 7.81 | CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. ( Becerra, L; Borsook, D; Kiefer, RT; Morris, S; Moulton, EA; Pendse, G; Rohr, P; Schwartzman, RJ; Wallin, D, 2015) |
| "Although ketamine is beneficial in treating complex regional pain syndrome (CRPS), a subset of patients respond poorly to therapy." | 7.81 | Analgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome. ( Ajit, SK; Alexander, GM; Aradillas-Lopez, E; Barrett, JE; Douglas, SR; Perreault, M; Qureshi, RA; Sacan, A; Schwartzman, RJ; Shenoda, BB, 2015) |
| "This study determined the pharmacokinetics and pharmacodynamics of (R)- and (S)-ketamine and (R)- and (S)-norketamine following a 5-day moderate dose, as a continuous (R,S)-ketamine infusion in complex regional pain syndrome (CRPS) patients." | 7.77 | Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome. ( Goldberg, ME; Mager, DE; Schwartzman, RJ; Torjman, MC; Wainer, IW, 2011) |
| "A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket." | 7.76 | A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. ( Bupp, JE; Furimsky, A; Goldberg, ME; Green, CE; Iyer, L; Moaddel, R; Tanga, MJ; Torjman, MC; Venkata, SL; Wainer, IW, 2010) |
| "To describe the treatment of an intractable complex regional pain syndrome I (CRPS-I) patient with anesthetic doses of ketamine supplemented with midazolam." | 7.74 | Complete recovery from intractable complex regional pain syndrome, CRPS-type I, following anesthetic ketamine and midazolam. ( Altemeyer, KH; Kiefer, RT; Ploppa, A; Rohr, P; Schwartzman, RJ, 2007) |
| "In this RCT, the primary objective is to demonstrate that an intermittent esketamine dosing regimen is non-inferior to a continuous esketamine dosing regimen at 3 months follow-up." | 7.30 | Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2). ( Baart, SJ; Bharwani, KD; de Vos, CC; Dik, WA; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Redekop, K; Siepman, TAM, 2023) |
| "Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism." | 6.48 | Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012) |
| "Ketamine is an open-channel NMDA blocker that only acts on those receptors whose Mg(2+) block has been lifted." | 6.47 | The use of ketamine in complex regional pain syndrome: possible mechanisms. ( Alexander, GM; Grothusen, JR; Schwartzman, RJ, 2011) |
| "Ketamine has been the focus of various studies involving the treatment of CRPS; however, currently, there is incomplete data from evidence-based studies." | 6.47 | Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome. ( Cooper, N; Domsky, R; Goldberg, ME; Hirsh, RA; Sabia, M; Torjman, MC; Wainer, IW, 2011) |
| "CRPS is also known as algodystrophy, causalgia, or reflex sympathetic dystrophy (RSD)." | 5.56 | Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020) |
| "Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction." | 5.43 | A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016) |
| "Ketamine is a centrally acting agent believed to work through blockade of N-methyl-D- aspartate receptors and is being increasingly used for the treatment of refractory CRPS, although the basis for the drug's effects and efficacy at different stages of the syndrome remains unclear." | 5.42 | Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice. ( Clark, JD; Huang, TT; Kingery, WS; Leu, D; Tajerian, M; Yang, P, 2015) |
| "This is a narrative review of intravenous ketamine infusions for the treatment of complex regional pain syndrome (CRPS)." | 5.41 | Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response. ( Lii, TR; Singh, V, 2023) |
| "We present a case of severe complex regional pain syndrome type 1 that was treated with oral ketamine." | 5.34 | Oral ketamine for the treatment of type I complex regional pain syndrome. ( Bayona, MJ; Cerdá-Olmedo, G; De Andrés, JA; Mínguez, A; Monsalve, V; Samper, JM; Villanueva-Perez, VL, 2007) |
| "A double-blind placebo-controlled crossover trial was used to determine the effects of topical ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, on the sensory disturbances in 20 patients with complex regional pain syndrome (CRPS)." | 5.14 | Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine. ( Drummond, PD; Finch, PM; Knudsen, L, 2009) |
| "This open-label trial suggests benefit in pain reduction, associated CRPS symptoms, improved quality of life and ability to work following anesthetic ketamine in previously refractory CRPS patients." | 5.13 | Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study. ( Altemeyer, KH; Dieterich, HJ; Grothusen, J; Kiefer, RT; Koffler, S; Ploppa, A; Rohr, P; Schwartzman, RJ; Unertl, K, 2008) |
| "This systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine." | 4.91 | A systematic review of ketamine for complex regional pain syndrome. ( Connolly, SB; Harden, RN; Prager, JP, 2015) |
| "Although the pain of fibromyalgia usually is not preceded by an injury to the involved tissue, whereas that of the complex regional pain syndrome usually starts at a site of prior trauma or surgery, both disorders may share a common mechanism-pathologic sensitization of brain mechanisms that integrate nociceptive signals-and both apparently respond to treatment with ketamine, an anesthetic-analgesic agent whose actions include blockade of N-methyl-D-aspartate receptors." | 4.86 | Fibromyalgia and the complex regional pain syndrome: similarities in pathophysiology and treatment. ( Wurtman, RJ, 2010) |
| "Ketamine infusions are frequently employed for refractory complex regional pain syndrome (CRPS), but there are limited data on factors associated with treatment response." | 4.31 | Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study. ( Cheng, J; Cohen, SJ; Cohen, SP; Khunsriraksakul, C; Moon, JY; Parker, E; Patel, N; Samen-Akinsiku, CDK; Yoo, Y; Yuan, X, 2023) |
| "This study was performed to compare the perfusion index (PI) between affected and unaffected limbs in patients with complex regional pain syndrome (CRPS); it also evaluated the usefulness of the PI for monitoring the response to intravenous ketamine infusion therapy in such patients." | 4.31 | Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome. ( Hong, SW; Hwang, MS; Kim, JH; Kim, M; Kim, SH, 2023) |
| " Thirty-one clinics used ketamine for chronic pain treatment." | 4.12 | Ketamine therapy for chronic pain in The Netherlands: a nationwide survey. ( Bharwani, KD; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2022) |
| " Neuropathic pain represents the first indication to use ketamine, followed, with a good to moderate utility, by other situations (fibromyalgia, complex regional pain syndrome, central neuropathic pain, peripheral neuropathic pain, nociceptive pain, sensitization, opioid withdrawal, palliative care, depression)." | 4.12 | Ketamine in chronic pain: A Delphi survey. ( Amodéo, JM; André, G; Barmaki, M; Collard, O; Colomb, C; Créac'h, C; de Chazeron, I; de Montgazon, G; Deleens, R; Delorme, C; Dixneuf, V; Dy, L; Gaillard, J; Gov, C; Kieffer, X; Lanteri-Minet, M; Le Borgne, JM; Le Caër, F; Maamar, F; Maindet, C; Marcaillou, F; Morel, V; Pickering, G; Plantevin, F; Pluchon, YM; Riant, T; Rioult, B; Rostaing, S; Salvat, E; Sep Hieng, V; Sorel, M; Vergne-Salle, P; Voute, M, 2022) |
| "The objective of this study was to assess the effectiveness of a low-dose intravenous S-ketamine treatment on refractory pain in patients with Complex Regional Pain Syndrome (CRPS)." | 4.02 | Effect of intravenous low-dose S-ketamine on pain in patients with Complex Regional Pain Syndrome: A retrospective cohort study. ( Bharwani, KD; de Vos, CC; Dirckx, M; Frankema, SPG; Huygen, FJPM; Mangnus, TJP; Stronks, DL, 2021) |
| "This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS." | 3.96 | Optimizing the Treatment of CRPS With Ketamine. ( Alexander, J; Bavry, E; Kirkpatrick, AF; Qiu, P; Saghafi, A; Schwartzman, R; Yang, K, 2020) |
| "To find and reach a consensus on the usage of ketamine in the treatment of complex regional pain syndrome and to determine a reference protocol for future studies." | 3.91 | Intravenous Ketamine Infusion for Complex Regional Pain Syndrome: Survey, Consensus, and a Reference Protocol. ( Anderson, S; Foorsov, V; Getson, P; Harbut, RE; Harden, RN; Herndon, C; Moskovitz, P; Xu, J, 2019) |
| "To evaluate the changes in glutamate/GABA balance of intracortical excitability produced by ketamine, delivered at subanaesthetic dose to treat patients with complex regional pain syndrome (CRPS)." | 3.88 | A reappraisal of the mechanisms of action of ketamine to treat complex regional pain syndrome in the light of cortical excitability changes. ( Armessen, C; Ayache, SS; Lefaucheur, JP; Locko, B; Sorel, M; Zrek, N, 2018) |
| "The efficacy of ketamine in relieving complex regional pain syndrome (CRPS) lacks predictive factors." | 3.88 | Three-phase Bone Scintigraphy Can Predict the Analgesic Efficacy of Ketamine Therapy in CRPS. ( Armessen, C; Beatrix, JC; Boucheneb, S; Domec, AM; Harache, B; Lecompte, O; Lefaucheur, JP; Locko, B; Robert, J; Sorel, M, 2018) |
| "Ketamine provides relief for a subset of patients with complex regional pain syndrome (CRPS)." | 3.83 | Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome. ( Ajit, SK; Alexander, GM; Shenoda, BB, 2016) |
| "Previous reports have indicated that ketamine anesthesia may produce significant improvement if not complete recovery of patients with complex regional pain syndrome (CRPS)." | 3.81 | CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome. ( Becerra, L; Borsook, D; Kiefer, RT; Morris, S; Moulton, EA; Pendse, G; Rohr, P; Schwartzman, RJ; Wallin, D, 2015) |
| "Although ketamine is beneficial in treating complex regional pain syndrome (CRPS), a subset of patients respond poorly to therapy." | 3.81 | Analgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome. ( Ajit, SK; Alexander, GM; Aradillas-Lopez, E; Barrett, JE; Douglas, SR; Perreault, M; Qureshi, RA; Sacan, A; Schwartzman, RJ; Shenoda, BB, 2015) |
| "This study determined the pharmacokinetics and pharmacodynamics of (R)- and (S)-ketamine and (R)- and (S)-norketamine following a 5-day moderate dose, as a continuous (R,S)-ketamine infusion in complex regional pain syndrome (CRPS) patients." | 3.77 | Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome. ( Goldberg, ME; Mager, DE; Schwartzman, RJ; Torjman, MC; Wainer, IW, 2011) |
| "A parallel chiral/achiral LC-MS/MS assay has been developed and validated to measure the plasma and urine concentrations of the enantiomers of ketamine, (R)- and (S)-Ket, in complex regional pain syndrome (CRPS) patients receiving a 5-day continuous infusion of a sub-anesthetic dose of (R,S)-Ket." | 3.76 | A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. ( Bupp, JE; Furimsky, A; Goldberg, ME; Green, CE; Iyer, L; Moaddel, R; Tanga, MJ; Torjman, MC; Venkata, SL; Wainer, IW, 2010) |
| "To describe the unusual course of postdural puncture headache (PDPH) after pump implantation for intrathecal baclofen (ITB) administration in patients with complex regional pain syndrome (CRPS)-related dystonia." | 3.75 | Postdural puncture headache in complex regional pain syndrome: a retrospective observational study. ( Delhaas, EM; Marinus, J; Munts, AG; van Hilten, JJ; Voormolen, JH, 2009) |
| "To describe the treatment of an intractable complex regional pain syndrome I (CRPS-I) patient with anesthetic doses of ketamine supplemented with midazolam." | 3.74 | Complete recovery from intractable complex regional pain syndrome, CRPS-type I, following anesthetic ketamine and midazolam. ( Altemeyer, KH; Kiefer, RT; Ploppa, A; Rohr, P; Schwartzman, RJ, 2007) |
| "In this RCT, the primary objective is to demonstrate that an intermittent esketamine dosing regimen is non-inferior to a continuous esketamine dosing regimen at 3 months follow-up." | 3.30 | Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2). ( Baart, SJ; Bharwani, KD; de Vos, CC; Dik, WA; Dirckx, M; Huygen, FJPM; Mangnus, TJP; Redekop, K; Siepman, TAM, 2023) |
| "Studies on oral ketamine for cancer and neuropathic pain have shown mixed results which could be partially due to significant differences in hepatic metabolism." | 2.48 | Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. ( Baker, K; Berger, AM; Handel, D; Mannes, AJ; Ruppert, SL; Soto, E; Stewart, DR; Zlott, D, 2012) |
| "Ketamine has been the focus of various studies involving the treatment of CRPS; however, currently, there is incomplete data from evidence-based studies." | 2.47 | Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome. ( Cooper, N; Domsky, R; Goldberg, ME; Hirsh, RA; Sabia, M; Torjman, MC; Wainer, IW, 2011) |
| "Ketamine is an open-channel NMDA blocker that only acts on those receptors whose Mg(2+) block has been lifted." | 2.47 | The use of ketamine in complex regional pain syndrome: possible mechanisms. ( Alexander, GM; Grothusen, JR; Schwartzman, RJ, 2011) |
| "The diagnosis and management of complex regional pain syndrome is often challenging." | 2.47 | Complex regional pain syndrome of the upper extremity. ( Koman, LA; Li, Z; Patterson, RW; Smith, BP; Smith, TL, 2011) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "CRPS is also known as algodystrophy, causalgia, or reflex sympathetic dystrophy (RSD)." | 1.56 | Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. ( Mundluru, T; Saraghi, M, 2020) |
| "Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction." | 1.43 | A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. ( Russo, MA; Santarelli, DM, 2016) |
| " We investigated the efficacy of ketamine in anaesthetic dosage in chronic, refractory CRPS patients that had failed available standard therapies." | 1.43 | Results of the Treatment of Chronic, Refractory CRPS with Ketamine Infusions: a Preliminary Report. ( Puchalski, P; Zyluk, A, 2016) |
| "Ketamine is a centrally acting agent believed to work through blockade of N-methyl-D- aspartate receptors and is being increasingly used for the treatment of refractory CRPS, although the basis for the drug's effects and efficacy at different stages of the syndrome remains unclear." | 1.42 | Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice. ( Clark, JD; Huang, TT; Kingery, WS; Leu, D; Tajerian, M; Yang, P, 2015) |
| "Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0." | 1.42 | Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. ( Cheung, CW; Choi, SW; Irwin, M; Liman, S; Ng, KF; Qiu, Q; Tai, W; Wong, KL, 2015) |
| "We present a case of severe complex regional pain syndrome type 1 that was treated with oral ketamine." | 1.34 | Oral ketamine for the treatment of type I complex regional pain syndrome. ( Bayona, MJ; Cerdá-Olmedo, G; De Andrés, JA; Mínguez, A; Monsalve, V; Samper, JM; Villanueva-Perez, VL, 2007) |
| "A chronic pain syndrome, similar to the complex regional pain syndrome (CRPS) described in human beings, was diagnosed in a cow with persisting severe pelvic limb lameness." | 1.33 | Continuous extradural analgesia in a cow with complex regional pain syndrome. ( Bergadano, A; Moens, Y; Schatzmann, U, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (17.54) | 29.6817 |
| 2010's | 34 (59.65) | 24.3611 |
| 2020's | 13 (22.81) | 2.80 |
| Authors | Studies |
|---|---|
| Voute, M | 1 |
| Riant, T | 1 |
| Amodéo, JM | 1 |
| André, G | 1 |
| Barmaki, M | 1 |
| Collard, O | 1 |
| Colomb, C | 1 |
| Créac'h, C | 1 |
| Deleens, R | 1 |
| Delorme, C | 1 |
| de Montgazon, G | 1 |
| Dixneuf, V | 1 |
| Dy, L | 1 |
| Gaillard, J | 1 |
| Gov, C | 1 |
| Kieffer, X | 1 |
| Lanteri-Minet, M | 1 |
| Le Borgne, JM | 1 |
| Le Caër, F | 1 |
| Maamar, F | 1 |
| Maindet, C | 1 |
| Marcaillou, F | 1 |
| Plantevin, F | 1 |
| Pluchon, YM | 1 |
| Rioult, B | 1 |
| Rostaing, S | 1 |
| Salvat, E | 1 |
| Sep Hieng, V | 1 |
| Sorel, M | 3 |
| Vergne-Salle, P | 1 |
| Morel, V | 1 |
| de Chazeron, I | 1 |
| Pickering, G | 1 |
| Cohen, SP | 1 |
| Khunsriraksakul, C | 1 |
| Yoo, Y | 1 |
| Parker, E | 1 |
| Samen-Akinsiku, CDK | 1 |
| Patel, N | 1 |
| Cohen, SJ | 1 |
| Yuan, X | 1 |
| Cheng, J | 1 |
| Moon, JY | 1 |
| Hong, SW | 1 |
| Hwang, MS | 1 |
| Kim, JH | 1 |
| Kim, M | 2 |
| Kim, SH | 1 |
| Mangnus, TJP | 3 |
| Dirckx, M | 3 |
| Bharwani, KD | 3 |
| Baart, SJ | 1 |
| Siepman, TAM | 1 |
| Redekop, K | 1 |
| Dik, WA | 1 |
| de Vos, CC | 2 |
| Huygen, FJPM | 3 |
| Lii, TR | 1 |
| Singh, V | 1 |
| Limerick, G | 1 |
| Christo, DK | 1 |
| Tram, J | 1 |
| Moheimani, R | 1 |
| Manor, J | 1 |
| Chakravarthy, K | 1 |
| Karri, J | 1 |
| Christo, PJ | 1 |
| Grinshpun, G | 1 |
| Shenoda, BB | 3 |
| Krevolin, LE | 1 |
| Sherman, M | 1 |
| Kirkpatrick, AF | 2 |
| Saghafi, A | 1 |
| Yang, K | 1 |
| Qiu, P | 1 |
| Alexander, J | 1 |
| Bavry, E | 1 |
| Schwartzman, R | 1 |
| Zhu, X | 1 |
| Kohan, LR | 1 |
| Goldstein, RB | 1 |
| Mundluru, T | 1 |
| Saraghi, M | 1 |
| Pande, R | 1 |
| Parikh, A | 1 |
| Shenoda, B | 1 |
| Ramanathan, S | 1 |
| Alexander, GM | 5 |
| Schwartzman, RJ | 9 |
| Ajit, SK | 3 |
| Frankema, SPG | 1 |
| Stronks, DL | 2 |
| Mandyam, MC | 1 |
| Ahuja, NK | 1 |
| Pasek, TA | 1 |
| Crowley, K | 1 |
| Campese, C | 1 |
| Lauer, R | 1 |
| Yang, C | 1 |
| Zhao, J | 1 |
| Wang, Y | 1 |
| Wang, D | 1 |
| Xu, J | 1 |
| Herndon, C | 1 |
| Anderson, S | 1 |
| Getson, P | 1 |
| Foorsov, V | 1 |
| Harbut, RE | 2 |
| Moskovitz, P | 1 |
| Harden, RN | 2 |
| Beatrix, JC | 1 |
| Locko, B | 2 |
| Armessen, C | 2 |
| Domec, AM | 1 |
| Lecompte, O | 1 |
| Boucheneb, S | 1 |
| Harache, B | 1 |
| Robert, J | 1 |
| Lefaucheur, JP | 2 |
| Zrek, N | 1 |
| Ayache, SS | 1 |
| O'Connell, NE | 1 |
| Wand, BM | 1 |
| McAuley, J | 1 |
| Marston, L | 1 |
| Moseley, GL | 1 |
| Birklein, F | 1 |
| O'Neill, D | 1 |
| Schlereth, T | 1 |
| Connolly, SB | 1 |
| Prager, JP | 1 |
| Douglas, SR | 1 |
| Qureshi, RA | 1 |
| Sacan, A | 1 |
| Perreault, M | 2 |
| Barrett, JE | 1 |
| Aradillas-Lopez, E | 1 |
| Goebel, A | 1 |
| Jayaseelan, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound Guided Versus Fluoroscopy Guided Lumber Sympathetic Block in Chronic Lower Limb Ischemia[NCT06073795] | 60 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| Long-term Pain Modulation by Intravenous Esketamine in Complex Regional Pain Syndrome: a Non-inferiority Study[NCT05212571] | 60 participants (Anticipated) | Interventional | 2022-04-19 | Enrolling by invitation | |||
| Infrared (FLIR) Imaging as a Monitor for Sympathetic Blocks in Complex Regional Pain Syndrome (CRPS)[NCT05693337] | 30 participants (Actual) | Observational | 2023-01-09 | Completed | |||
| Pilot Study on the Assessment of Motor Imaging Skills in Patients With Complex Regional Pain Syndrome (CRPS)[NCT04703348] | 129 participants (Actual) | Interventional | 2021-01-12 | Completed | |||
| Comparison of Gut Microbial Composition and Function in CRPS Patients vs. Healthy Individuals[NCT05473338] | 250 participants (Anticipated) | Observational | 2022-04-14 | Active, not recruiting | |||
| Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
| Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash[NCT01566448] | Phase 2 | 30 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Oral Ketamine for Control of Chronic Pain in Children[NCT01369680] | Phase 1 | 12 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| A Safe Ketamine-Based Therapy for Treatment Resistant Depression[NCT01179009] | 20 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| (2R,6R)-Hydroxynorketamine a Novel Therapeutic Analgesic for the Treatment of Neuropathic Pain: A Randomized Double Blind Cross-Over Trial.[NCT05864053] | Phase 1/Phase 2 | 25 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia[NCT02987855] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2018-12-15 | Withdrawn (stopped due to Withdrawn [COVID restrictions prevent patient enrollment or treatment. Clinical Trial facility is being closed due to viral limitations and loss of staff to perform]) | ||
| Ketamine Frequency Treatment for Major Depressive Disorder[NCT00646087] | Phase 4 | 0 participants (Actual) | Interventional | 2008-03-31 | Withdrawn (stopped due to Pilot study determined that this study would not be feasible.) | ||
| Spreading Depolarization and Ketamine Suppression[NCT02501941] | Phase 1 | 10 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in pain score as reported at baseline and after the use of ketamine mouthwash on a numeric scale from 0 to 10, with 0 representing no pain and 10 representing the worst pain. (NCT01566448)
Timeframe: 1 hour after baseline
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 2 |
Sleep quality, as reported by the subject on a numeric scale (1-10) will be used as a surrogate marker of quality of life with 0 indicating no sleep and 10 indicating the best sleep you have had. (NCT01566448)
Timeframe: Day 1 after start of ketamine mouthwashes
| Intervention | score on a scale (Median) |
|---|---|
| Ketamine | 1 |
Change of topical lidocaine uses in 24 hour period (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes
| Intervention | lidocaine doses per day (Median) |
|---|---|
| Ketamine | 1 |
Change in IV morphine equivalents of opioid requirements (NCT01566448)
Timeframe: Days 1 after start of ketamine mouthwashes
| Intervention | IV morphine equivalents (Median) |
|---|---|
| Ketamine | 12 |
"Baseline neurocognitive testing will be done before study drug is given. Subjects will be reassessed for any changes in neurocognitive scores at end of dosing (week 2) and at three weeks off study drug (week 14). Significant changes were measured at week 14 compared to baseline. Week 2 was measured to inform future studies.~The neurocognitive scores are standardized scores with a mean of 100; low scores correlate with low neurocognitive function, while high scores correlate with high function. A significant change is defined as greater than or equal to 10% decrease in scores." (NCT01369680)
Timeframe: At 14 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 0 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 0 |
| Ketamine 1.5 mg/kg/Dose | 0 |
Pharmacokinetic testing will be done during chronic ketamine administration on subjects consenting to additional testing one week into study drug administration. This is to further describe the activity of ketamine in the blood of children when administered chronically and to enable comparison of any clinical effect or toxicity with steady state levels of ketamine in children. (NCT01369680)
Timeframe: At week 1
| Intervention | ng/mL (Mean) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 37.5 |
| Ketamine 0.5 mg/kg/Dose | 135 |
| Ketamine 1 mg/kg/Dose | 250 |
According to CTCae any dose causing grade 2 or worse toxicity will be an untolerated dose. Tolerability is defined as ability to take the medication for 2 weeks without having a grade 2 or worse toxicity. (NCT01369680)
Timeframe: Up to 2 weeks
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 3 |
| Ketamine 1 mg/kg/Dose | 3 |
| Ketamine 1.5 mg/kg/Dose | 1 |
"Subjects will be assessed for clinically significant change in pain scores during and after study drug administration. Significant change in pain scores were determined at week 2, though week 14 scores were collected as well.~Participants with a 2 point (or greater) decrease in pain scores compared to baseline were considered to have responded. The NRS scale was used, the scale ranges from 0-10, with 10 being the most pain." (NCT01369680)
Timeframe: Week 2
| Intervention | participants (Number) |
|---|---|
| Ketamine 0.25 mg/kg/Dose | 3 |
| Ketamine 0.5 mg/kg/Dose | 0 |
| Ketamine 1 mg/kg/Dose | 2 |
| Ketamine 1.5 mg/kg/Dose | 0 |
The Montgomery-Asberg Depression Rating Scale (MADRS) is a 10-item scale that measures the severity of depression, with a higher score indicating a higher level of depression. The range of scores is 0 to 60. (NCT01179009)
Timeframe: 8 weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| Ketamine 100-hour Infusion | -9.0 |
| Ketamine 40-minute Infusion | -6.4 |
14 reviews available for ketamine and Complex Regional Pain Syndrome
| Article | Year |
|---|---|
Ketamine for Complex Regional Pain Syndrome: A Narrative Review Highlighting Dosing Practices and Treatment Response.
Topics: Complex Regional Pain Syndromes; Humans; Infusions, Intravenous; Ketamine; Pain Management | 2023 |
Complex Regional Pain Syndrome: Evidence-Based Advances in Concepts and Treatments.
Topics: Child; Complex Regional Pain Syndromes; Female; Humans; Ketamine; Male; Pain Management; Pain Measur | 2023 |
Case Study of High-Dose Ketamine for Treatment of Complex Regional Pain Syndrome in the Pediatric Intensive Care Unit.
Topics: Adult; Advanced Practice Nursing; Analgesics; Complex Regional Pain Syndromes; Female; Humans; Inten | 2017 |
The Effect of Ketamine Infusion in the Treatment of Complex Regional Pain Syndrome: a Systemic Review and Meta-analysis.
Topics: Analgesics; Complex Regional Pain Syndromes; Dose-Response Relationship, Drug; Humans; Infusions, In | 2018 |
Interventions for treating pain and disability in adults with complex regional pain syndrome.
Topics: Adult; Analgesics; Calcitonin; Complex Regional Pain Syndromes; Diphosphonates; Disabled Persons; Gu | 2013 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
Complex regional pain syndrome: An optimistic perspective.
Topics: Analgesics; Autonomic Nervous System Diseases; Bone Density Conservation Agents; Complex Regional Pa | 2015 |
A systematic review of ketamine for complex regional pain syndrome.
Topics: Analgesics; Complex Regional Pain Syndromes; Humans; Ketamine | 2015 |
Fibromyalgia and the complex regional pain syndrome: similarities in pathophysiology and treatment.
Topics: Complex Regional Pain Syndromes; Fibromyalgia; Humans; Ketamine | 2010 |
Advances in translational neuropathic research: example of enantioselective pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief in complex regional pain syndrome.
Topics: Animals; Complex Regional Pain Syndromes; Drug Evaluation, Preclinical; Humans; Ketamine; Models, Bi | 2011 |
The use of ketamine in complex regional pain syndrome: possible mechanisms.
Topics: Anesthetics, Dissociative; Complex Regional Pain Syndromes; Humans; Ketamine; Neuralgia; Receptors, | 2011 |
Oral ketamine in the palliative care setting: a review of the literature and case report of a patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome.
Topics: Administration, Oral; Adult; Analgesics; Complex Regional Pain Syndromes; Female; Glomus Tumor; Huma | 2012 |
Complex regional pain syndrome of the upper extremity.
Topics: Adrenal Cortex Hormones; Analgesics; Anticonvulsants; Antidepressive Agents; Autonomic Nerve Block; | 2011 |
Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.
Topics: Complex Regional Pain Syndromes; Excitatory Amino Acid Antagonists; Humans; Ketamine | 2012 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
4 trials available for ketamine and Complex Regional Pain Syndrome
| Article | Year |
|---|---|
Intermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2).
Topics: Adult; Chronic Pain; Complex Regional Pain Syndromes; Humans; Ketamine; Quality of Life; Randomized | 2023 |
Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine.
Topics: Administration, Topical; Adult; Complex Regional Pain Syndromes; Double-Blind Method; Excitatory Ami | 2009 |
Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine.
Topics: Administration, Topical; Adult; Complex Regional Pain Syndromes; Double-Blind Method; Excitatory Ami | 2009 |
Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine.
Topics: Administration, Topical; Adult; Complex Regional Pain Syndromes; Double-Blind Method; Excitatory Ami | 2009 |
Reduction of allodynia in patients with complex regional pain syndrome: A double-blind placebo-controlled trial of topical ketamine.
Topics: Administration, Topical; Adult; Complex Regional Pain Syndromes; Double-Blind Method; Excitatory Ami | 2009 |
Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study.
Topics: Adult; Analgesics; Analysis of Variance; Complex Regional Pain Syndromes; Double-Blind Method; Drug | 2009 |
Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study.
Topics: Adult; Analgesics; Analysis of Variance; Complex Regional Pain Syndromes; Double-Blind Method; Drug | 2009 |
Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study.
Topics: Adult; Analgesics; Analysis of Variance; Complex Regional Pain Syndromes; Double-Blind Method; Drug | 2009 |
Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study.
Topics: Adult; Analgesics; Analysis of Variance; Complex Regional Pain Syndromes; Double-Blind Method; Drug | 2009 |
Efficacy of ketamine in anesthetic dosage for the treatment of refractory complex regional pain syndrome: an open-label phase II study.
Topics: Activities of Daily Living; Adolescent; Anesthetics, Dissociative; Complex Regional Pain Syndromes; | 2008 |
39 other studies available for ketamine and Complex Regional Pain Syndrome
| Article | Year |
|---|---|
Ketamine in chronic pain: A Delphi survey.
Topics: Chronic Pain; Complex Regional Pain Syndromes; Humans; Ketamine; Neuralgia; Pain, Intractable | 2022 |
Sympathetic Blocks as a Predictor for Response to Ketamine Infusion in Patients with Complex Regional Pain Syndrome: A Multicenter Study.
Topics: Autonomic Nerve Block; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic D | 2023 |
Usefulness of the perfusion index for monitoring the response to intravenous ketamine infusion therapy in patients with complex regional pain syndrome.
Topics: Analgesics; Complex Regional Pain Syndromes; Humans; Infusions, Intravenous; Ketamine; Perfusion Ind | 2023 |
Chronic Pain Syndromes: Complex Regional Pain Syndrome.
Topics: Chronic Pain; Complex Regional Pain Syndromes; Gabapentin; Humans; Ketamine; Physical Therapy Modali | 2023 |
Syndrome of Inappropriate Antidiuretic Hormone Release During Ketamine Infusion in Complex Regional Syndrome Patient Receiving Intrathecal Baclofen: A Case Report.
Topics: Baclofen; Complex Regional Pain Syndromes; Female; Humans; Inappropriate ADH Syndrome; Injections, I | 2019 |
Optimizing the Treatment of CRPS With Ketamine.
Topics: Chronic Pain; Complex Regional Pain Syndromes; Humans; Ketamine; Pain Measurement; Pain Threshold | 2020 |
Substantial Elevation of Liver Enzymes During Ketamine Infusion: A Case Report.
Topics: Analgesics; Chemical and Drug Induced Liver Injury; Complex Regional Pain Syndromes; Female; Humans; | 2020 |
Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine.
Topics: Anesthetics; Complex Regional Pain Syndromes; Humans; Ketamine; Pain; Reflex Sympathetic Dystrophy | 2020 |
Hsa-miR-605 regulates the proinflammatory chemokine CXCL5 in complex regional pain syndrome.
Topics: Analgesics; Cell Movement; Chemokine CXCL5; Complex Regional Pain Syndromes; Down-Regulation; HEK293 | 2021 |
Effect of intravenous low-dose S-ketamine on pain in patients with Complex Regional Pain Syndrome: A retrospective cohort study.
Topics: Analgesics; Complex Regional Pain Syndromes; Humans; Infusions, Intravenous; Ketamine; Pain, Intract | 2021 |
Ketamine therapy for chronic pain in The Netherlands: a nationwide survey.
Topics: Analgesics; Chronic Pain; Complex Regional Pain Syndromes; Humans; Ketamine; Netherlands | 2022 |
Ketamine-Induced Mania During Treatment for Complex Regional Pain Syndrome.
Topics: Analgesics; Animals; Bipolar Disorder; Complex Regional Pain Syndromes; Humans; Ketamine; Treatment | 2017 |
Intravenous Ketamine Infusion for Complex Regional Pain Syndrome: Survey, Consensus, and a Reference Protocol.
Topics: Analgesics; Complex Regional Pain Syndromes; Consensus; Humans; Infusions, Intravenous; Ketamine; Pa | 2019 |
Three-phase Bone Scintigraphy Can Predict the Analgesic Efficacy of Ketamine Therapy in CRPS.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Bone and Bones; Complex Regional Pain Syndromes; Female; | 2018 |
A reappraisal of the mechanisms of action of ketamine to treat complex regional pain syndrome in the light of cortical excitability changes.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cerebral Cortex; Complex Regional Pain Syndromes; Cortic | 2018 |
Analgesic Response to Intravenous Ketamine Is Linked to a Circulating microRNA Signature in Female Patients With Complex Regional Pain Syndrome.
Topics: Administration, Intravenous; Adult; Aged; Analgesics; Complex Regional Pain Syndromes; Female; Gene | 2015 |
Racemic ketamine 4.5-day infusion treatment of long-standing complex regional pain syndrome—a prospective service evaluation in five patients.
Topics: Adult; Analgesics; Complex Regional Pain Syndromes; Female; Humans; Infusions, Intravenous; Ketamine | 2015 |
Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Complex Regional Pain Syndromes; Disease Mod | 2015 |
Differential Efficacy of Ketamine in the Acute versus Chronic Stages of Complex Regional Pain Syndrome in Mice.
Topics: Acute Disease; Analgesics; Animals; Chronic Disease; Complex Regional Pain Syndromes; Disease Models | 2015 |
A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients.
Topics: Adrenergic alpha-Agonists; Adult; Analgesics; Anesthetics, Dissociative; Anti-Infective Agents, Loca | 2016 |
CNS Measures of Pain Responses Pre- and Post-Anesthetic Ketamine in a Patient with Complex Regional Pain Syndrome.
Topics: Adult; Brain; Brain Mapping; Complex Regional Pain Syndromes; Evoked Potentials, Somatosensory; Fema | 2015 |
The Effects of Long-Term Ketamine Treatment on Cognitive Function in Complex Regional Pain Syndrome: A Preliminary Study.
Topics: Adult; Analgesics; Cognition; Complex Regional Pain Syndromes; Female; Humans; Ketamine; Male; Middl | 2016 |
Hsa-miR-34a mediated repression of corticotrophin releasing hormone receptor 1 regulates pro-opiomelanocortin expression in patients with complex regional pain syndrome.
Topics: Adrenocorticotropic Hormone; alpha-MSH; beta-Endorphin; Body Mass Index; Complex Regional Pain Syndr | 2016 |
Results of the Treatment of Chronic, Refractory CRPS with Ketamine Infusions: a Preliminary Report.
Topics: Adult; Analgesics; Complex Regional Pain Syndromes; Female; Humans; Ketamine; Pain Measurement | 2016 |
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu | 2017 |
Postdural puncture headache in complex regional pain syndrome: a retrospective observational study.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Baclofen; Blood Patch, Epidural; Causality; Cerebrospi | 2009 |
Intravenous ketamine for CRPS: Making too much of too little?
Topics: Analgesics; Complex Regional Pain Syndromes; Humans; Injections, Intravenous; Ketamine | 2010 |
What is considered long-term pain relief in chronic pain management? Re: Sigtermans et al., Pain 2009;145:304-311.
Topics: Analgesics; Chronic Disease; Complex Regional Pain Syndromes; Cost-Benefit Analysis; Drug Administra | 2010 |
Development of a complicated pain syndrome following cyanide poisoning in a U.S. soldier.
Topics: Adult; Afghan Campaign 2001-; Analgesics; Complex Regional Pain Syndromes; Cyanides; Drug Contaminat | 2010 |
Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome.
Topics: Adolescent; Adult; Analgesics; Chromatography, Liquid; Complex Regional Pain Syndromes; Female; Huma | 2011 |
Response to Drs. Bell and Moore commentary regarding the use of intravenous ketamine for CRPS.
Topics: Analgesics; Complex Regional Pain Syndromes; Double-Blind Method; Humans; Injections, Intravenous; K | 2010 |
Regarding Bell and Moore, intravenous ketamine for CRPS: making too much of too little? Pain 2010;150:10-11.
Topics: Analgesics; Complex Regional Pain Syndromes; Humans; Injections, Intravenous; Ketamine | 2010 |
A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.
Topics: Analgesics; Biotransformation; Calibration; Chromatography, Liquid; Complex Regional Pain Syndromes; | 2010 |
A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.
Topics: Analgesics; Biotransformation; Calibration; Chromatography, Liquid; Complex Regional Pain Syndromes; | 2010 |
A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.
Topics: Analgesics; Biotransformation; Calibration; Chromatography, Liquid; Complex Regional Pain Syndromes; | 2010 |
A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome.
Topics: Analgesics; Biotransformation; Calibration; Chromatography, Liquid; Complex Regional Pain Syndromes; | 2010 |
Stereoselective and regiospecific hydroxylation of ketamine and norketamine.
Topics: Anesthetics, Dissociative; Complex Regional Pain Syndromes; Cytochrome P-450 Enzyme System; Humans; | 2012 |
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.
Topics: Adolescent; Adult; Aged; Analgesics; Complex Regional Pain Syndromes; Disease-Free Survival; Dose-Re | 2004 |
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.
Topics: Adolescent; Adult; Aged; Analgesics; Complex Regional Pain Syndromes; Disease-Free Survival; Dose-Re | 2004 |
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.
Topics: Adolescent; Adult; Aged; Analgesics; Complex Regional Pain Syndromes; Disease-Free Survival; Dose-Re | 2004 |
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.
Topics: Adolescent; Adult; Aged; Analgesics; Complex Regional Pain Syndromes; Disease-Free Survival; Dose-Re | 2004 |
Continuous extradural analgesia in a cow with complex regional pain syndrome.
Topics: Analgesics; Animals; Bupivacaine; Catheterization; Cattle; Complex Regional Pain Syndromes; Diagnosi | 2006 |
Oral ketamine for the treatment of type I complex regional pain syndrome.
Topics: Administration, Oral; Adult; Analgesics; Complex Regional Pain Syndromes; Female; Humans; Ketamine; | 2007 |
Complete recovery from intractable complex regional pain syndrome, CRPS-type I, following anesthetic ketamine and midazolam.
Topics: Adolescent; Analgesics; Complex Regional Pain Syndromes; Disease Progression; Female; Follow-Up Stud | 2007 |
Role of ketamine in 'vicarious pain'.
Topics: Analgesics; Anesthetics, Local; Brachial Plexus; Bupivacaine; Complex Regional Pain Syndromes; Human | 2008 |