ketamine has been researched along with Inadequate Sleep in 10 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The dose-response effects of ketamine, an intravenous anesthetic with psychotomimetic properties which is a ketone derivative of phencyclidine, were evaluated in several experimental animal models of aggression." | 7.67 | Effects of ketamine on experimental animal models of aggression. ( Monteiro-de-Lima, TC; Morato, GS; Takahashi, RN, 1984) |
| "The dose-response effects of ketamine, an intravenous anesthetic with psychotomimetic properties which is a ketone derivative of phencyclidine, were evaluated in several experimental animal models of aggression." | 3.67 | Effects of ketamine on experimental animal models of aggression. ( Monteiro-de-Lima, TC; Morato, GS; Takahashi, RN, 1984) |
| "Ketamine effects were compared to changes during control (saline) injections and after 6 h gentle handling sleep deprivation (SD)." | 1.91 | Ketamine affects homeostatic sleep regulation in the absence of the circadian sleep-regulating component in freely moving rats. ( Détári, L; Hajnik, T; Sviatkó, K; Tóth, A, 2023) |
| "Several non-pharmacological treatments of depression upregulate adenosine concentration and/or adenosine A1 receptors (A1R) in the brain." | 1.42 | Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. ( Biber, K; Clement, HW; de Bartolomeis, A; Iasevoli, F; Idzko, M; Jacobson, KA; Normann, C; Schwarz, MK; Serchov, T; Tosh, DK; van Calker, D, 2015) |
| "While selective REM sleep deprivation had the same effects, combined influences of ketamine and REM-sleep deprivation led to a marked potentiation of their individual effects probably by simultaneous stimulation of the neurone system which determines the endogenous electrical activity of LGN cells." | 1.26 | Potentiation of ketamine effects on the spiking activity in the lateral geniculate nucleus by rapid eye movement (REM) sleep deprivation. ( Susic, V, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Melgers, M | 1 |
| Meijer, JH | 1 |
| Deboer, T | 1 |
| Tóth, A | 1 |
| Sviatkó, K | 1 |
| Détári, L | 1 |
| Hajnik, T | 1 |
| Orozco-Solis, R | 1 |
| Montellier, E | 1 |
| Aguilar-Arnal, L | 1 |
| Sato, S | 1 |
| Vawter, MP | 2 |
| Bunney, BG | 3 |
| Bunney, WE | 3 |
| Sassone-Corsi, P | 1 |
| DeVylder, J | 1 |
| Wang, XL | 1 |
| Yuan, K | 1 |
| Zhang, W | 1 |
| Li, SX | 1 |
| Gao, GF | 1 |
| Lu, L | 1 |
| Li, JZ | 1 |
| Walsh, DM | 1 |
| Stein, R | 1 |
| Cartagena, P | 1 |
| Barchas, JD | 1 |
| Schatzberg, AF | 1 |
| Myers, RM | 1 |
| Watson, SJ | 1 |
| Akil, H | 1 |
| Serchov, T | 1 |
| Clement, HW | 1 |
| Schwarz, MK | 1 |
| Iasevoli, F | 1 |
| Tosh, DK | 1 |
| Idzko, M | 1 |
| Jacobson, KA | 1 |
| de Bartolomeis, A | 1 |
| Normann, C | 1 |
| Biber, K | 1 |
| van Calker, D | 1 |
| Takahashi, RN | 1 |
| Morato, GS | 1 |
| Monteiro-de-Lima, TC | 1 |
| Susic, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646] | Phase 4 | 154 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketamine and Inadequate Sleep
| Article | Year |
|---|---|
Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.
Topics: Affect; Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder, Major; Humans; Ketami | 2020 |
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Topics: Animals; Antidepressive Agents; Chronobiology Disorders; CLOCK Proteins; Depressive Disorder, Major; | 2015 |
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Topics: Animals; Antidepressive Agents; Chronobiology Disorders; CLOCK Proteins; Depressive Disorder, Major; | 2015 |
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Topics: Animals; Antidepressive Agents; Chronobiology Disorders; CLOCK Proteins; Depressive Disorder, Major; | 2015 |
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.
Topics: Animals; Antidepressive Agents; Chronobiology Disorders; CLOCK Proteins; Depressive Disorder, Major; | 2015 |
Rapid-acting antidepressant strategies: mechanisms of action.
Topics: Depressive Disorder; Humans; Ketamine; Sleep Deprivation; Time Factors | 2012 |
7 other studies available for ketamine and Inadequate Sleep
| Article | Year |
|---|---|
Comparison of sleep deprivation and a low dose of ketamine on sleep and the electroencephalogram in Brown Norway rats.
Topics: Animals; Electroencephalography; Ketamine; Rats; Sleep; Sleep Deprivation; Sleep, REM | 2023 |
Ketamine affects homeostatic sleep regulation in the absence of the circadian sleep-regulating component in freely moving rats.
Topics: Animals; Circadian Rhythm; Electroencephalography; Humans; Ketamine; Rats; Sleep; Sleep Deprivation; | 2023 |
A Circadian Genomic Signature Common to Ketamine and Sleep Deprivation in the Anterior Cingulate Cortex.
Topics: Animals; Antidepressive Agents; Circadian Rhythm Signaling Peptides and Proteins; Computational Biol | 2017 |
Sleep as an Underused Target for Rapid Response in the Treatment of Depression and Suicidal Ideation.
Topics: Anesthetics, Dissociative; Deep Brain Stimulation; Depression; Humans; Ketamine; Sleep Deprivation; | 2016 |
Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a.
Topics: Animals; Carrier Proteins; Depression; Homer Scaffolding Proteins; Humans; Imipramine; Ketamine; Mic | 2015 |
Effects of ketamine on experimental animal models of aggression.
Topics: Aggression; Animals; Apomorphine; Dose-Response Relationship, Drug; Humans; Ketamine; Male; Mice; Mi | 1984 |
Potentiation of ketamine effects on the spiking activity in the lateral geniculate nucleus by rapid eye movement (REM) sleep deprivation.
Topics: Action Potentials; Animals; Cats; Geniculate Bodies; Ketamine; Sleep Deprivation; Sleep, REM; Wakefu | 1976 |