Page last updated: 2024-09-27

Sphincter of Oddi Dysfunction

Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter.

Synonyms(3)

Synonym
Sphincter of Oddi Dysfunction
Sphincter of Oddi Dyskinesia
Sphincter of Oddi Stenosis

Research

Studies (36)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's10 (27.78)18.1394
2010's25 (69.44)28.8240
2020's1 (2.78)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaldehyde0low10
acetone0low10
benzene0low10
glycine0low10
nitrates0low20
trimethylamine0low10
diclofenac0low10
indomethacin0medium41
ketamine0low10
mebeverine0low10
neostigmine0medium21
nifedipine0low10
nitroglycerin0low10
trimebutine0low10
phenylalanine0medium11
carbon disulfide0low10
pentane0low10
thiazoles0low10
ursodeoxycholic acid0low10
nitazoxanide0low10
nitrosobis(2-oxopropyl)amine0low10
duloxetine hydrochloride0low10
technetium tc 99m pentetate0medium21
morphine0medium41
morphinans0low10
sincalide0low30
eluxadoline0medium11
technetium tc 99m mebrofenin0low10
cholecystokinin0low40
motilin0low10
gastrins0low20
phosphatidylcholines0low10
vasoactive intestinal peptide0low10
naloxegol0low10
rome0low10
da 81590medium11

Protein Targets (454)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma7007
SMAD family member 23003
SMAD family member 33003
GLI family zinc finger 35005
AR protein6006
caspase 7, apoptosis-related cysteine protease2002
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor6006
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha7007
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor2002
activating transcription factor 62002
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x2002
Caspase-71001
caspase-31001
thyroid hormone receptor beta isoform 27007
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 17007
Voltage-dependent calcium channel gamma-2 subunit4004
Cellular tumor antigen p536006
Glutamate receptor 24004
ATPase family AAA domain-containing protein 55005
Ataxin-25005
TDP1 protein6006
lamin isoform A-delta109009
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor3003
cellular tumor antigen p53 isoform a3003
Endolysin0011
Integrin beta-32002
Integrin alpha-IIb2002
Luciferase6006
aldehyde dehydrogenase 1 family, member A13003
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Prostaglandin G/H synthase 1 0203
Transient receptor potential cation channel subfamily A member 10011
Bile salt export pump010010
Dihydrofolate reductase0101
Cytochrome c oxidase subunit 20202
Carbonic anhydrase 10203
Carbonic anhydrase 20203
Fatty acid-binding protein, liver0101
Transthyretin0013
Albumin0224
Prostaglandin G/H synthase 10304
Cytochrome P450 3A40415
Interleukin-80202
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Cytochrome P450 2C9 0203
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10303
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40101
Prostaglandin G/H synthase 10202
Sodium- and chloride-dependent GABA transporter 10202
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0202
UDP-glucuronosyltransferase 1A30002
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0202
Cytochrome P450 2J20202
Prostaglandin G/H synthase 20303
Prostaglandin G/H synthase 20203
Carbonic anhydrase 90102
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0202
Carbonic anhydrase 40101
Multidrug and toxin extrusion protein 10202
P2Y purinoceptor 120202
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
glp-1 receptor, partial2002
Fumarate hydratase2002
Smad32002
cytochrome P450 family 3 subfamily A polypeptide 46006
cytochrome P450 2D64004
polyprotein2002
IDH12002
aryl hydrocarbon receptor5005
potassium voltage-gated channel subfamily H member 2 isoform d1001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin6006
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Interferon beta5005
Alpha-synuclein2002
Spike glycoprotein4004
Canalicular multispecific organic anion transporter 10606
Delta-type opioid receptor0315
Mu-type opioid receptor0328
Mu-type opioid receptor0225
Delta-type opioid receptor0236
Kappa-type opioid receptor0303
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0416
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0416
Glutamate receptor ionotropic, NMDA 2B0416
Glutamate receptor ionotropic, NMDA 2C0416
Large neutral amino acids transporter small subunit 10203
Glutamate receptor ionotropic, NMDA 2D0416
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0416
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0416
Sodium- and chloride-dependent glycine transporter 20101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Cruzipain1001
interleukin 81001
Microtubule-associated protein tau3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
EWS/FLI fusion protein2002
G4004
67.9K protein2002
glucocerebrosidase1001
Parkin2002
bromodomain adjacent to zinc finger domain 2B3003
euchromatic histone-lysine N-methyltransferase 25005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor2002
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform a3003
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 13003
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A2002
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
HLA class I histocompatibility antigen, B alpha chain 4004
Procathepsin L0101
ATP-dependent translocase ABCB10303
Neuronal acetylcholine receptor subunit alpha-40101
Androgen receptor0011
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Thromboxane-A synthase 0202
Adenosine receptor A10102
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10202
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0203
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor2002
C-X-C chemokine receptor type 30101
Nuclear receptor ROR-gamma3003
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G3003
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Potassium voltage-gated channel subfamily H member 20303
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Inositol hexakisphosphate kinase 14004
Dehydrogenase/reductase SDR family member 90101
Solute carrier organic anion transporter family member 1B30203
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
cytochrome P450 2C9, partial4004
chromobox protein homolog 13003
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0303
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 31001
Sodium channel protein type 4 subunit alpha0202
Cholinesterase0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
Chain A, Beta-lactamase3003
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 13003
histone acetyltransferase KAT2A isoform 12002
Gamma-aminobutyric acid receptor subunit pi3003
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Gamma-aminobutyric acid receptor subunit epsilon3003
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0011
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Kappa-type opioid receptor0214
Kappa-type opioid receptor0214
Kappa-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0102
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
GLS protein2002
regulator of G-protein signaling 42002
arylsulfatase A1001
muscarinic acetylcholine receptor M12002
Cholinesterase0202
Acetylcholinesterase0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
thioredoxin reductase1001
phosphopantetheinyl transferase2002
ATAD5 protein, partial1001
USP1 protein, partial1001
NFKB1 protein, partial1001
Thrombopoietin1001
hypothetical protein, conserved2002
nonstructural protein 11001
beta-2 adrenergic receptor1001
Bloom syndrome protein isoform 11001
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
perilipin-50101
perilipin-10101
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 12002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Potassium channel subfamily K member 20011
Glutathione reductase, mitochondrial0202
Cytochrome P450 1A20101
Muscarinic acetylcholine receptor M20001
Muscarinic acetylcholine receptor M40001
Muscarinic acetylcholine receptor M50001
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Phospholipase A2, membrane associated0001
5-hydroxytryptamine receptor 2A0213
Alpha-1B adrenergic receptor0202
Muscarinic acetylcholine receptor M30001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Potassium voltage-gated channel subfamily A member 50101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
5-hydroxytryptamine receptor 2C0202
Adenosine receptor A2a0101
Adenosine receptor A10202
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0101
C-C chemokine receptor type 20202
Alpha-1A adrenergic receptor0202
Inositol monophosphatase 11001
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0203
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Sodium channel protein type 5 subunit alpha0101
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Sodium channel protein type 9 subunit alpha0101
Transient receptor potential cation channel subfamily A member 10011
Potassium channel subfamily K member 2 0101
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
ATP-dependent phosphofructokinase1001
PPM1D protein1001
pyruvate kinase1001
NPC intracellular cholesterol transporter 1 precursor1001
histone deacetylase 9 isoform 32002
huntingtin isoform 21001
pyruvate kinase PKM isoform a1001
lethal factor (plasmid)1001
Endothelin receptor type B1001
Endothelin-1 receptor1001
Signal transducer and activator of transcription 30101
Pyruvate-flavodoxin oxidoreductase0101
Anoctamin-10101
Carbonic anhydrase 40102
Carbonic anhydrase0102
Sodium/iodide cotransporter0101
Carbonic anhydrase 150102
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Carbonic anhydrase 120001
Plasma kallikrein0001
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30001
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Carbonic anhydrase 60001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
E3 ubiquitin-protein ligase XIAP0101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Monocarboxylate transporter 100001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0001
Sphingosine kinase 20202
Sphingosine kinase 10101
Chain A, Ferritin light chain1001
Cholecystokinin receptor type A0101
Cholecystokinin receptor type A0202
Gastrin/cholecystokinin type B receptor0112
Cholecystokinin receptor type A0224
Gastrin/cholecystokinin type B receptor0224
Gastrin/cholecystokinin type B receptor0202
Cholecystokinin receptor type A0202
Solute carrier organic anion transporter family member 1B20001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Ubiquitin carboxyl-terminal hydrolase 20101
Glucocorticoid receptor0011
Vitamin D3 receptor0112
Ileal sodium/bile acid cotransporter0101
TAR DNA-binding protein 431001
Sodium/bile acid cotransporter0101
G-protein coupled bile acid receptor 10011
Bile acid receptor0011
CDGSH iron-sulfur domain-containing protein 10202
M1-family alanyl aminopeptidase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]