Renal Colic

A severe intermittent and spasmodic pain in the lower back radiating to the groin, scrotum, and labia which is most commonly caused by a kidney stone (RENAL CALCULUS) passing through the URETER or by other urinary track blockage. It is often associated with nausea, vomiting, fever, restlessness, dull pain, frequent urination, and HEMATURIA.

Synonym
Renal Colic

Excerpt	Reference
"(1) Renal colic is an acute syndrome involving unilateral flank pain, linked to an obstruction in the upper urinary tract."	( , 2009)
"Renal colic is generated by hyperperistalsis of the obstructed ureter."	( Hess, B, 2011)
"Renal colic is classically sudden in onset, unilateral, and radiates from loin to groin."	( Maxwell, AP; Xavier, A, 2011)
"Renal colic is typically characterized by the sudden onset of severe pain radiating from the flank to the groin and its acute management in emergency departments essentially aims at rapid pain relief."	( Helmy, S; Salem, A; Yakoot, M; Yousef, S, 2014)
"Sixty percent of renal colics are due to stones below pelvic brim."	( Dhanasekaran, AK; Elangovan, A; John, B; KandaSwamy, GV; Vedanayagam, KS; Viswaroop, B, 2015)
"Renal colic is acute pain caused by urinary stones."	( Afshar, K; Eftekhari, A; Jafari, S; MacNeily, AE; Marks, AJ, 2015)
"Pain from renal colic is often severe and incapacitating."	( Chang, SL; Steinberg, PL, 2016)
"Renal colic is one of the most intense pains known to humans."	( Del Rosario-Santiago, M; Garduño-Arteaga, ML; Maldonado-Avila, M; Manzanilla-Garcia, HA; Rios-Davila, VM; Rodriguez-Nava, P; Rosas-Nava, JE; Vela-Mollinedo, RA, 2017)
"Renal colic is a common, acute presentation of urolithiasis that requires immediate pain relief."	( Cameron, PA; Mitra, B; Pathan, SA, 2018)
"Adult renal colic is a frequent lombo-abdominal painful syndrome in emergencies."	( Boukadida, L; Boukef, R; Chabaane, W; Haj Ali, A; Jebali, C; Ousgi, A, 2017)
"Renal colic is a prevalent cause of abdominal pain in the emergency department."	( Baigi, V; Entezari, P; Hedayatshodeh, M; Jalili, M; Mirfazaelian, H; Shirani, F, 2019)
"Renal colic is one of the most common painful disorders in patients referred to the emergency department."	( Mirzaee, M; Nazemian, N; Torabi, M, 2020)
"Acute renal colic is one of the common causes of referral to the hospitals."	( Astaraki, P; Kalantari, A; Rezaei, B; Salimi, R, 2021)
"Renal colic is a common cause of pain; however, there have been few reports of treating this pain with regional anesthesia."	( Bechis, SK; Finneran, JJ; Ilfeld, BM, 2020)
"Renal colic is the pain experienced by a patient when a renal calculus (kidney stone) causes partial or complete obstruction of part of the renal outflow tract."	( Bedford, E; Chester, V; Fakis, A; Jackson, R; Johnson, G; Mason, S; Ratan, H; Sherman, R; Tabner, A, 2022)
"Renal colic is described as one of the worst types of pain, and effective analgesia in the shortest possible time is of paramount importance."	( Cao, Y; Jia, LC; Li, HW; Liu, BL; Liu, CZ; Pei, XL; Qu, ZC; Shi, GX; Tu, JF; Wang, LQ; Yan, SY; Yang, JW; Yao, WH, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	24 (12.06)	23.3326
1990's	0 (0.00)	12.5806
2000's	2 (1.01)	18.1394
2010's	123 (61.81)	28.8240
2020's	50 (25.13)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	2	0
phloroglucinol	medium	2	2
glycerol	low	2	0
nitrites	low	1	0
nitrous oxide	medium	1	1
uric acid	low	8	0
urea	low	1	0
hydroxyindoleacetic acid	low	1	0
acetazolamide	low	3	0
albuterol	medium	1	1
benzbromarone	low	1	0
bupivacaine	low	1	0
chlorothiazide	low	1	0
fentanyl	medium	8	4
furosemide	low	1	0
haloperidol	medium	1	1
hexamethonium	low	2	0
hydrochlorothiazide	low	1	0
ibuprofen	medium	1	1
iodixanol	low	1	0
iohexol	low	1	0
meperidine	medium	2	1
nefopam	medium	1	1
nifedipine	medium	3	2
aminosalicylic acid	low	1	0
papaverine	medium	4	3
phenolphthalein	low	1	0
prazosin	low	1	0
procaine	low	3	0
trimethoprim	low	1	0
phentolamine	low	1	0
aminopyrine	low	1	0
ethyl chloride	low	1	0
tromethamine	medium	3	2
methylprednisolone	low	1	0
isoxazoles	medium	2	2
aminophylline	low	1	0
docusate	low	1	0
potassium citrate	low	1	0
streptomycin	low	1	0
gadolinium	low	1	0
magnesium sulfate	medium	4	3
tricalcium phosphate	low	3	0
trolamine salicylate	low	1	0
calcium oxalate	low	3	0
tramadol	medium	1	1
substance p	medium	1	1
fomesafen	low	2	0
iobitridol	low	1	0
aceclofenac	medium	1	1
tadalafil	medium	2	2
tamsulosin	medium	23	6
cinacalcet	low	1	0
dexketoprofen trometamol	medium	3	2
eunalgit	low	1	0
noscapine	medium	1	1
dipyrone	low	2	0
bromochloroacetic acid	low	1	0
drotaverin	medium	1	1
D-fructopyranose	low	1	0
dinoprostone	low	1	0
codeine	medium	1	1
naloxone	low	1	0
topiramate	low	1	0
silodosin	medium	1	1
butylscopolammonium bromide	medium	5	2
struvite	low	1	0
scopolamine hydrobromide	low	1	0
jaw	low	1	0
technetium tc 99m sestamibi	low	1	0
spasmofen	medium	1	1
tetracycline	low	1	0
mobiflex	medium	1	1
lornoxicam	medium	2	2
rome	low	1	0
lactoferrin	low	1	0
allopurinol	low	1	0

Protein Targets (1,039)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
GLS protein	16	0	0	16
GLI family zinc finger 3	26	0	0	26
estrogen receptor 2 (ER beta)	10	0	0	10
progesterone receptor	16	0	0	16
retinoid X nuclear receptor alpha	19	0	0	19
G	17	0	0	17
peroxisome proliferator activated receptor gamma	14	0	0	14
cytochrome P450 2C9 precursor	12	0	0	12
chromobox protein homolog 1	21	0	0	21
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
geminin	29	0	0	29
lamin isoform A-delta10	24	0	0	24
ATP-binding cassette sub-family C member 3	0	31	0	31
Multidrug resistance-associated protein 4	0	31	0	32
Bile salt export pump	0	40	0	40
Interferon beta	20	0	0	20
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Transthyretin	0	0	2	4
Mitogen-activated protein kinase 1	0	2	0	2
Histamine H2 receptor	14	0	0	15
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Inositol hexakisphosphate kinase 1	17	0	0	17
cytochrome P450 2C9, partial	17	0	0	17
RAR-related orphan receptor gamma	25	0	0	25
ATAD5 protein, partial	13	0	0	13
Microtubule-associated protein tau	11	0	0	11
Smad3	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
thyroid stimulating hormone receptor	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	20	0	0	20
EWS/FLI fusion protein	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	23	0	0	23
estrogen-related nuclear receptor alpha	24	0	0	24
estrogen nuclear receptor alpha	35	0	0	35
aryl hydrocarbon receptor	12	0	0	12
thyroid hormone receptor beta isoform 2	17	0	0	17
peripheral myelin protein 22	12	0	0	12
cytochrome P450 3A4 isoform 1	14	0	0	14
Gamma-aminobutyric acid receptor subunit pi	14	1	0	15
Solute carrier family 22 member 6	0	8	0	8
Carbonic anhydrase 12	0	6	1	11
UDP-glucuronosyltransferase 1A9	0	2	0	5
Bile salt export pump	0	6	0	6
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	12	1	19
Carbonic anhydrase 2	0	13	2	20
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	1	4
Prostaglandin G/H synthase 1	0	8	0	9
Carbonic anhydrase 3	0	6	1	9
Cytochrome P450 3A4	0	9	2	12
Cytochrome P450 2D6	0	6	1	7
Cytochrome P450 2C9	0	18	0	19
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	14	1	0	15
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	14	1	0	15
Gamma-aminobutyric acid receptor subunit gamma-2	14	1	0	15
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	13	0	0	13
Gamma-aminobutyric acid receptor subunit alpha-5	14	1	0	15
Gamma-aminobutyric acid receptor subunit alpha-3	14	1	0	15
Arachidonate 5-lipoxygenase-activating protein	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	2	0	4
Carbonic anhydrase 4	0	7	1	11
Prostaglandin G/H synthase 1	0	8	0	8
Carbonic anhydrase 6	0	6	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	14	1	0	15
Gamma-aminobutyric acid receptor subunit alpha-2	14	1	0	15
Gamma-aminobutyric acid receptor subunit alpha-4	14	1	0	15
Gamma-aminobutyric acid receptor subunit gamma-3	14	1	0	15
Gamma-aminobutyric acid receptor subunit alpha-6	14	1	0	15
Carbonic anhydrase 5A, mitochondrial	0	6	2	12
Prostaglandin G/H synthase 2	0	9	1	11
Carbonic anhydrase 7	0	6	1	10
Nuclear receptor ROR-gamma	5	0	0	5
Cytochrome P450 2J2	0	14	0	14
Gamma-aminobutyric acid receptor subunit alpha-1	14	1	0	15
Gamma-aminobutyric acid receptor subunit beta-3	14	1	0	15
Gamma-aminobutyric acid receptor subunit beta-2	14	1	0	15
Carbonic anhydrase 9	0	7	1	12
GABA theta subunit	14	1	0	15
Canalicular multispecific organic anion transporter 1	0	29	0	29
Carbonic anhydrase 15	0	4	0	5
Carbonic anhydrase 13	0	6	0	9
Gamma-aminobutyric acid receptor subunit epsilon	14	1	0	15
Carbonic anhydrase 14	0	6	1	11
Carbonic anhydrase 5B, mitochondrial	0	6	1	11
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	11	0	0	11
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	16	0	0	16
GALC protein	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	19	0	0	19
glucocorticoid receptor [Homo sapiens]	18	0	0	18
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	2	0	2
arylsulfatase A	9	0	0	9
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
Bloom syndrome protein isoform 1	7	0	0	7
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
survival motor neuron protein isoform d	10	0	0	10
muscleblind-like protein 1 isoform 1	6	0	0	6
Carbonic anhydrase	0	2	0	2
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	6	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
5-hydroxytryptamine receptor 2A	0	8	0	8
Androgen receptor	0	3	0	3
Translocator protein	0	1	1	2
Cannabinoid receptor 1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	4	0	4
Serum paraoxonase/arylesterase 1	0	6	0	6
Dipeptidyl peptidase 4	0	1	0	2
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	4	1	5
5-hydroxytryptamine receptor 2B	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Delta-type opioid receptor	0	10	1	13
Cytochrome P450 2C19	0	5	0	5
Delta-type opioid receptor	0	11	4	16
Mu-type opioid receptor	0	10	4	17
Carbonic anhydrase	0	3	0	3
Kappa-type opioid receptor	0	8	1	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	3	2	0	5
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	8	1	10
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	12	1	13
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	6	0	6
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	5	0	5
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	5	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
glp-1 receptor, partial	4	0	0	4
regulator of G-protein signaling 4	10	0	0	10
NPYLR7B	0	0	1	1
thyroid stimulating hormone receptor	7	0	0	7
flap endonuclease 1	4	0	0	4
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	0	2	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-3 adrenergic receptor	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	3	2	6
ATP-dependent phosphofructokinase	10	0	0	10
interleukin 8	4	0	0	4
TDP1 protein	21	0	0	21
AR protein	23	0	0	23
IDH1	8	0	0	8
transcriptional regulator ERG isoform 3	3	0	0	3
ras-related protein Rab-9A	8	0	0	8
Polyphenol oxidase 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	16	0	0	16
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	1	1	2
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	6	0	0	6
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
USP1 protein, partial	13	0	0	13
Chain A, Ferritin light chain	1	0	0	1
Luciferase	14	0	0	14
15-lipoxygenase, partial	6	0	0	6
pregnane X nuclear receptor	21	0	0	21
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
histone deacetylase 9 isoform 3	4	0	0	4
Nicotinate phosphoribosyltransferase	0	2	0	2
ORF73	0	0	2	2
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
thioredoxin glutathione reductase	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
calpain II, partial	0	1	0	1
Skn7p	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
envelope glycoprotein	0	1	0	1
nonstructural protein 1	7	0	0	7
farnesoid X nuclear receptor	12	0	0	12
cytochrome P450 2D6	14	0	0	14
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
photoreceptor-specific nuclear receptor	0	1	0	1
Histone H2A.x	8	0	0	8
cytochrome P450 2C19 precursor	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
perilipin-5	0	3	0	3
vitamin D3 receptor isoform VDRA	7	0	0	7
nuclear receptor corepressor 2 isoform 2	0	1	0	1
perilipin-1	0	3	0	3
heat shock protein beta-1	6	0	0	6
DNA polymerase beta	2	0	0	2
mitogen-activated protein kinase 1	10	0	0	10
serine/threonine-protein kinase PLK1	2	0	0	2
peroxisome proliferator-activated receptor gamma isoform 2	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	3	0	3
histone acetyltransferase KAT2A isoform 1	5	0	0	5
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
streptokinase A precursor	0	0	1	1
Eyes absent homolog 2	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Polymerase acidic protein	0	0	1	1
Estrogen receptor	0	0	1	1
Adenosine receptor A3	0	4	0	4
Alpha-1B adrenergic receptor	0	14	3	17
Multidrug resistance-associated protein 1	0	3	0	3
Alpha-synuclein	2	1	0	3
5-hydroxytryptamine receptor 2B	0	10	0	10
Alpha-1A adrenergic receptor	0	15	3	18
Monocarboxylate transporter 1	0	1	0	1
Spike glycoprotein	21	1	1	23
Eyes absent homolog 3	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Solute carrier family 22 member 6	0	7	0	9
Estrogen receptor beta	0	0	1	1
Monocarboxylate transporter 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Bile acid receptor	0	0	1	1
Solute carrier family 22 member 12	0	1	0	1
Eyes absent homolog 3	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
M17 leucyl aminopeptidase	0	1	0	1
M1-family alanyl aminopeptidase	0	1	0	1
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	3	2	5
Potassium channel subfamily K member 9	0	1	0	1
acetylcholinesterase	10	0	0	10
NFKB1 protein, partial	10	0	0	10
muscarinic acetylcholine receptor M1	11	0	0	11
Proteasome subunit beta type-11	0	0	0	1
phosphopantetheinyl transferase	8	0	0	8
Fumarate hydratase	7	0	0	7
Thrombopoietin	4	0	0	4
caspase 7, apoptosis-related cysteine protease	3	0	0	3
NADPH oxidase 1	0	1	0	1
polyprotein	7	0	0	7
67.9K protein	8	0	0	8
Snq2p	0	0	0	1
caspase-3	3	0	0	3
Adenylate cyclase type 1	0	3	0	3
Caspase-7	1	0	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
cytochrome P450 2D6 isoform 1	8	0	0	8
cellular tumor antigen p53 isoform a	4	0	0	4
D(1A) dopamine receptor	5	0	0	5
caspase-3	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	7	0	0	7
M-phase phosphoprotein 8	6	0	0	6
lethal factor (plasmid)	7	0	0	7
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	9	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transmembrane protease serine 2	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Epidermal growth factor receptor	0	4	0	4
Albumin	0	7	4	11
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Integrin beta-3	4	0	0	4
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	2	1	3
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	5	0	6
Muscarinic acetylcholine receptor M4	0	5	0	6
ATP-dependent translocase ABCB1	0	7	0	10
Muscarinic acetylcholine receptor M1	0	7	0	7
Muscarinic acetylcholine receptor M3	0	6	0	6
Muscarinic acetylcholine receptor M4	0	6	0	6
Integrin alpha-IIb	4	0	0	4
5-hydroxytryptamine receptor 1A	0	5	0	5
Muscarinic acetylcholine receptor M5	0	6	0	6
Muscarinic acetylcholine receptor M5	0	5	0	6
Alpha-2A adrenergic receptor	0	9	2	13
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M2	0	7	1	8
Muscarinic acetylcholine receptor M1	0	6	0	7
Angiotensin-converting enzyme	0	7	0	7
D(2) dopamine receptor	0	6	1	10
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	1	11
Alpha-2C adrenergic receptor	0	9	1	12
D	0	5	0	5
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1A	0	5	0	5
Alpha-2B adrenergic receptor	0	7	4	11
D(2) dopamine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	4	0	5
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	4	0	6
D(4) dopamine receptor	0	6	1	10
D(1B) dopamine receptor	0	3	0	5
Adenylate cyclase type 3	0	3	0	3
Alpha-2C adrenergic receptor	0	6	4	10
UDP-glucuronosyltransferase 1A4	0	1	0	3
Alpha-2A adrenergic receptor	0	6	4	10
Alpha-1D adrenergic receptor	0	10	3	14
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	6	0	6
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	12	3	17
D(1B) dopamine receptor	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	0	3
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	8	0	8
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	2	0	2
D(4) dopamine receptor	0	4	0	4
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Histamine H1 receptor	0	6	0	6
Mu-type opioid receptor	0	14	7	23
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
D(3) dopamine receptor	0	7	1	11
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	5	0	5
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	12	2	16
Kappa-type opioid receptor	0	12	3	17
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	5	0	5
Gastrin/cholecystokinin type B receptor	0	2	0	2
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	1	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2C	0	4	0	4
Sodium channel protein type 7 subunit alpha	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	19	0	19
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	8
Sodium channel protein type 5 subunit alpha	0	6	0	6
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 2D	0	4	0	4
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	4	0	4
D	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Proteasome subunit beta type-7	0	0	0	1
Ataxin-2	7	0	0	7
Sigma non-opioid intracellular receptor 1	0	9	1	10
Angiotensin-converting enzyme 2	0	2	1	3
Sodium channel protein type 3 subunit alpha	0	4	0	4
Glutamate receptor ionotropic, NMDA 3A	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	3	0	3
PPM1D protein	4	0	0	4
PINK1	1	0	0	1
Parkin	6	0	0	6
huntingtin isoform 2	2	0	0	2
nuclear receptor ROR-gamma isoform 1	8	0	0	8
Glycine receptor subunit alpha-1	0	0	1	1
Extracellular calcium-sensing receptor	0	0	1	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	8
Kappa-type opioid receptor	0	5	1	8
Mu-type opioid receptor	0	6	1	10
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
endonuclease IV	3	0	0	3
dopamine D1 receptor	2	0	0	2
pregnane X receptor	2	0	0	2
peripheral myelin protein 22 isoform 1	7	0	0	7
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
Glucocorticoid receptor	0	4	0	4
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
Multidrug and toxin extrusion protein 1	0	7	0	7
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	5
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	4	0	4
Cytochrome c oxidase subunit 2	0	2	0	2
Fatty acid-binding protein, liver	0	3	0	3
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	4	1	5
Aldo-keto reductase family 1 member B1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	5
UDP-glucuronosyltransferase 1A3	0	0	0	5
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	6	0	6
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	4	0	5
P2Y purinoceptor 12	0	2	0	2
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Chain A, Cruzipain	2	0	0	2
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 7	0	1	0	3
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	5	0	7
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	1	0	3
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
neuropeptide S receptor isoform A	3	0	0	3
Sodium/bile acid cotransporter	0	2	0	2
NPC1-like intracellular cholesterol transporter 1	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	5	3	9
Sigma non-opioid intracellular receptor 1	0	4	1	5
thyrotropin-releasing hormone receptor	1	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
glucocerebrosidase	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
Histamine H1 receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Alpha-1A adrenergic receptor	0	9	4	17
5-hydroxytryptamine receptor 2A	0	1	0	1
Alpha-1B adrenergic receptor	0	9	4	15
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Hsf1 protein	0	0	2	2
Guanine nucleotide-binding protein G	3	0	0	3
hypothetical protein, conserved	2	0	0	2
alpha-galactosidase	2	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	4
Albumin	0	1	0	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	3	0	4
Substance-P receptor	0	3	0	3
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	3	0	3
Caspase-9	0	3	0	3
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Androgen receptor	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chymotrypsinogen A	0	1	0	1
Acetylcholinesterase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	2	2
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Adenosine receptor A1	0	3	0	3
UDP-glucuronosyltransferase 1A8	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Tubulin beta 8B	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Tubulin beta-4A chain	0	0	2	2
Tubulin beta chain	0	0	2	2
Tubulin alpha-3C chain	0	0	2	2
Tubulin alpha-1B chain	0	0	2	2
Tubulin alpha-4A chain	0	0	2	2
Tubulin beta-4B chain	0	0	2	2
Tubulin beta-3 chain	0	0	2	2
Tubulin beta-2A chain	0	0	2	2
Tubulin beta-8 chain	0	0	2	2
Tubulin beta-2B chain	0	1	0	1
Tubulin alpha-3E chain	0	0	2	2
Tubulin alpha-1A chain	0	0	2	2
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Tubulin alpha-1C chain	0	0	2	2
Tubulin beta-6 chain	0	0	2	2
Tubulin beta-2B chain	0	0	2	2
Tubulin beta-1 chain	0	0	2	2
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	1	4
Vascular endothelial growth factor receptor 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	3
Nuclear receptor subfamily 4 group A member 2	0	1	0	1
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
G-protein coupled receptor 55	0	1	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
ClpP	1	0	0	1
estrogen receptor beta isoform 1	0	2	0	2
Alpha-1A adrenergic receptor	0	3	3	6
Alpha-1A adrenergic receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	3	0	3
Nischarin	0	1	0	1
Beta-secretase 1	0	1	0	1
interferon gamma precursor	0	0	0	1
Solute carrier family 22 member 3	0	1	0	1
Beta-casein	0	1	0	1
Interstitial collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	4	0	4
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphodiesterase	0	1	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (199)

Protein Targets (1,039)

Renal Colic

Synonyms(1)

Research Excerpts

Overview

Research

Studies (199)

Drugs Studied (102)

Protein Targets (1,039)