Franceschetti-Zwahlen-Klein Syndrome

A hereditary disorder occurring in two forms: the complete form (Franceschetti's syndrome) is characterized by antimongoloid slant of the palpebral fissures, COLOBOMA of the lower lid, MICROGNATHIA and hypoplasia of the ZYGOMATIC ARCHES, and CONGENITAL MICROTIA. It is transmitted as an autosomal trait. The incomplete form (Treacher Collins syndrome) is characterized by the same anomalies in less pronounced degree. It occurs sporadically, but an autosomal dominant mode of transmission is suspected. (Dorland, 27th ed)

Synonyms(5)

Synonym
Treacher Collins Syndrome
Franceschetti-Zwahlen-Klein Syndrome
Mandibulofacial Dysostosis
Mandibulofacial Dysostosis (MFD1)
Treacher Collins-Franceschetti Syndrome

Research Excerpts

Overview

Excerpt	Reference
"Treacher Collins syndrome is a congenital craniofacial malformation affecting the structures derived from the first and second brachial arches."	( Gui, L; Liu, J; Niu, F; Tang, X; Yu, B; Zhang, Z, 2009)
"Treacher Collins syndrome is an autosomal dominant disorder of craniofacial development with an incidence of I in 40,000 to in 70,000 live births."	( Aydin, B; Beken, S; Dilli, D; Dinlen, N; Okumuş, N; Zenciroğlu, A, 2014)

Treatment

Excerpt	Reference
"The optimal timing and treatment of Treacher Collins syndrome with regard to zygomatico-orbital osseous reconstruction has not been fully established."	( Bradley, JP; Fan, KL; Federico, C; Kawamoto, HK, 2012)

Research

Studies (174)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	100 (57.47)	23.3326
1990's	20 (11.49)	12.5806
2000's	22 (12.64)	18.1394
2010's	28 (16.09)	28.8240
2020's	4 (2.30)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	2
lactic acid	low	1
5,6-dihydroorotate	low	2
iodine	low	1
nitrous oxide	low	1
orotic acid	low	2
pyridoxine	low	1
aminopropionitrile	low	1
acetazolamide	low	2
aspirin	low	2
caffeine	low	1
flumazenil	low	1
flunitrazepam	low	1
halothane	low	3
lidocaine	low	1
isoflurane	low	1
isoniazid	low	1
2-propanol	low	10
ketamine	low	2
apnea	low	1
phenacetin	low	1
phenobarbital	low	1
primidone	low	1
procainamide	low	1
propofol	low	2
propranolol	low	1
sevoflurane	low	1
terbutaline	low	1
thalidomide	low	7
prednisone	low	1
alanine	low	1
lysine	low	1
uridine	low	1
medroxyprogesterone acetate	low	1
valine	low	1
arginine	low	1
pyrimidine	low	1
ephedrine	low	1
medroxyprogesterone	low	1
glycopyrrolate	low	1
durapatite	low	1
streptomycin	low	1
titanium	low	2
calcium phosphate, dibasic, anhydrous	low	1
calcium phosphate, monobasic, anhydrous	low	1
tricalcium phosphate	low	1
calcium sulfate	low	1
trolamine salicylate	low	3
propiconazole	low	36
paroxetine	low	1
fomesafen	low	1
calcium pyrophosphate	low	1
atropine	low	1
elastin	low	1
inositol 3-phosphate	low	5
rocuronium	low	1
tretinoin	low	5
retinol	low	5
isomethyleugenol	low	1
mercaptopurine	low	1
digoxin	low	1
quinine	low	1
etretinate	low	3
isotretinoin	low	3
phenylephrine hydrochloride	low	26
dexmedetomidine	low	1
fluorapatite	low	1
jaw	low	6
endothelin-1	low	1
ubiquinone	low	2
cx 5461	low	1
salicylates	low	1
transforming growth factor beta	low	1
chondroitin sulfates	low	1
alcian blue	low	1
eye	low	13

Protein Targets (746)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	21	0	0	21
GLI family zinc finger 3	24	0	0	24
AR protein	24	0	0	24
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	18	0	0	18
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator-activated receptor delta	9	0	0	9
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	4	0	0	4
thyroid hormone receptor beta isoform a	9	0	0	9
heat shock protein beta-1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	21	0	0	21
lamin isoform A-delta10	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Glutamate receptor 2	11	0	0	11
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	13	0	0	13
GALC protein	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
glucocorticoid receptor [Homo sapiens]	18	0	0	18
estrogen-related nuclear receptor alpha	23	0	0	23
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	8	0	0	8
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	21	0	0	21
Bloom syndrome protein isoform 1	9	0	0	9
geminin	18	0	0	18
peripheral myelin protein 22	7	0	0	7
survival motor neuron protein isoform d	5	0	0	5
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	7	6	2	15
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	18
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	25	0	25
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	8	1	14
Carbonic anhydrase 2	0	8	1	13
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	4	1	6
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	5	1	7
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	6	1	7
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	3	1	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	7	6	2	15
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	6	2	15
Gamma-aminobutyric acid receptor subunit gamma-2	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-5	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-3	7	6	2	15
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	3	1	5
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	7	6	2	15
Gamma-aminobutyric acid receptor subunit alpha-2	7	6	2	15
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	5
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	6	2	15
Gamma-aminobutyric acid receptor subunit gamma-3	7	6	2	15
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	6	2	15
Adenosine receptor A2a	0	4	0	6
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	3	1	4
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	4	1	5
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	7	2	16
Gamma-aminobutyric acid receptor subunit beta-3	7	6	2	15
Gamma-aminobutyric acid receptor subunit beta-2	7	6	2	15
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	7	6	2	15
Canalicular multispecific organic anion transporter 1	0	18	0	18
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	6	2	15
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	1	0	1
Adenosine deaminase	0	0	0	1
ATAD5 protein, partial	7	0	0	7
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
TDP1 protein	20	0	0	20
Microtubule-associated protein tau	6	0	0	6
D(1A) dopamine receptor	4	0	0	4
neuropeptide S receptor isoform A	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	10	0	0	10
NFKB1 protein, partial	1	0	0	1
GLS protein	9	0	0	9
thyroid stimulating hormone receptor	8	0	0	8
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	10	0	0	10
flap endonuclease 1	5	0	0	5
DNA polymerase iota isoform a (long)	9	0	0	9
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	7	0	0	7
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	1	0	0	1
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	2	2	9
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
pregnane X nuclear receptor	16	0	0	16
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	5	0	6
5-hydroxytryptamine receptor 4	0	6	0	6
Muscarinic acetylcholine receptor M2	0	7	2	12
Muscarinic acetylcholine receptor M4	0	5	1	8
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	6	2	11
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	7	2	11
Alpha-1D adrenergic receptor	0	3	1	5
5-hydroxytryptamine receptor 2C	0	6	1	7
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	2	0	0	3
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
farnesoid X nuclear receptor	11	0	0	11
thyroid stimulating hormone receptor	12	0	0	12
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform 2	14	0	0	14
nuclear receptor ROR-gamma isoform 1	8	0	0	8
Potassium channel subfamily K member 2	0	2	1	3
Cholinesterase	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	6	1	7
Replicase polyprotein 1ab	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	4	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	7	0	0	7
Alpha-2A adrenergic receptor	0	2	3	6
Alpha-1B adrenergic receptor	0	6	1	7
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	2	3	6
Alpha-2B adrenergic receptor	0	2	1	3
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	3	1	4
Alpha-1A adrenergic receptor	0	6	1	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	6	0	0	6
PAX8	0	0	0	1
SMAD family member 2	6	0	0	6
PPM1D protein	1	0	0	1
SMAD family member 3	6	0	0	6
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
Smad3	2	0	0	2
estrogen receptor 2 (ER beta)	10	0	0	10
progesterone receptor	13	0	0	13
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	4	0	0	4
peroxisome proliferator activated receptor gamma	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
tumor necrosis factor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Interferon beta	9	0	0	9
Cellular tumor antigen p53	16	0	0	16
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	6	0	8
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	7	0	0	7
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Endothelin-1 receptor	0	2	1	3
USP1 protein, partial	5	0	0	5
G	8	0	0	8
aryl hydrocarbon receptor	8	0	0	8
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
endonuclease IV	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Bile salt export pump	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	4	8
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
5-hydroxytryptamine receptor 1A	0	4	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
TAR DNA-binding protein 43	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Luciferase	6	0	0	6
vitamin D3 receptor isoform VDRA	8	0	0	8
Albumin	0	2	2	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
acetylcholinesterase	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
histone acetyltransferase KAT2A isoform 1	5	0	0	5
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chain A, Ferritin light chain	4	0	0	4
Parkin	4	0	0	4
Caspase-7	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
caspase-3	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Alpha-2B adrenergic receptor	0	2	1	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	8	1	9
Cellular retinoic acid-binding protein 1	0	0	2	2
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Sodium channel protein type 4 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
mitogen-activated protein kinase 1	3	0	0	3
Potassium channel subfamily K member 3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
PINK1	2	0	0	2
Glucocorticoid receptor	0	6	2	8
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Spike glycoprotein	5	0	0	5
pregnane X receptor	6	0	0	6
nonstructural protein 1	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Estrogen receptor	0	1	1	2
Sex hormone-binding globulin	0	0	1	1
Progesterone receptor	0	2	1	3
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	0	3
Alpha-synuclein	1	2	0	3
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Estrogen receptor beta	0	1	1	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Fumarate hydratase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
polyprotein	1	0	0	1
hemoglobin subunit beta	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
5-hydroxytryptamine receptor 1A	0	1	1	2
Quinolone resistance protein NorA	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	1	5
Sodium-dependent dopamine transporter	0	2	0	2
Beta-adrenergic receptor kinase 1	0	1	2	3
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	4	1	5
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	2	1	3
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Transporter	0	2	0	2
Cytochrome P450 1A2	0	0	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
glp-1 receptor, partial	3	0	0	3
beta-2 adrenergic receptor	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
dopamine D1 receptor	1	0	0	1
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	3
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	2	3	5
Beta-1 adrenergic receptor	0	2	2	4
Beta-2 adrenergic receptor	0	2	0	3
Beta-3 adrenergic receptor	0	2	2	4
D(2) dopamine receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
D(3) dopamine receptor	0	1	0	1
D(1A) dopamine receptor	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	3
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	4	1	6
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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