| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| clonazepam | [no description available] | medium | 4 | 0 | 1,4-benzodiazepinone;
monochlorobenzenes | anticonvulsant;
anxiolytic drug;
GABA modulator |
| nordazepam | [no description available] | medium | 3 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative |
| diazepam | [no description available] | medium | 3 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic |
| flunitrazepam | [no description available] | medium | 43 | 0 | 1,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes | anxiolytic drug;
GABAA receptor agonist;
sedative |
| flunitrazepam | [no description available] | medium | 43 | 1 | 1,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes | anxiolytic drug;
GABAA receptor agonist;
sedative |
| lorazepam | [no description available] | medium | 3 | 0 | benzodiazepine | |
| nitrazepam | [no description available] | medium | 5 | 0 | 1,4-benzodiazepinone;
C-nitro compound | anticonvulsant;
antispasmodic drug;
drug metabolite;
GABA modulator;
sedative |
| cm 7116 | [no description available] | medium | 2 | 0 | benzodiazepine | |
| oxazepam | [no description available] | medium | 4 | 0 | 1,4-benzodiazepinone;
organochlorine compound | anxiolytic drug;
environmental contaminant;
xenobiotic |
| temazepam | [no description available] | medium | 2 | 0 | benzodiazepine | |
| chlordesmethyldiazepam | [no description available] | medium | 2 | 0 | benzodiazepine | |
| halazepam | [no description available] | medium | 2 | 0 | organic molecular entity | |
| n-desmethylflunitrazepam | [no description available] | medium | 2 | 0 | | |
| 7-aminonitrazepam | [no description available] | medium | 3 | 0 | benzodiazepine | |
| 7-aminoclonazepam | [no description available] | medium | 4 | 0 | benzodiazepine | |
| ro 5-3438 | [no description available] | medium | 2 | 0 | | |
| n-desmethylflunitrazepam | [no description available] | medium | 8 | 0 | | |
| ro 05-4082 | [no description available] | medium | 2 | 0 | | |
| meclonazepam | [no description available] | medium | 1 | 0 | | |
| ro 11-6893 | [no description available] | medium | 1 | 0 | | |
| methacrylic acid | [no description available] | medium | 1 | 0 | alpha,beta-unsaturated monocarboxylic acid | |
| lauryl methacrylate | [no description available] | medium | 1 | 0 | | |
| ethylene dimethacrylate | [no description available] | medium | 1 | 0 | enoate ester | allergen;
cross-linking reagent;
polymerisation monomer |
| n-methyl-n-(trimethylsilyl)trifluoroacetamide | [no description available] | medium | 1 | 0 | monocarboxylic acid amide;
N-silyl compound;
trifluoroacetamide | chromatographic reagent |
| 6-o-monoacetylmorphine | [no description available] | medium | 3 | 0 | morphinane alkaloid | |
| cocaine | [no description available] | medium | 3 | 0 | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic |
| methadone | [no description available] | medium | 3 | 0 | benzenes;
diarylmethane;
ketone;
tertiary amino compound | |
| codeine | [no description available] | medium | 1 | 0 | morphinane alkaloid;
organic heteropentacyclic compound | antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic |
| morphine | [no description available] | medium | 4 | 0 | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic |
| dihydrocodeine | [no description available] | medium | 1 | 0 | morphinane alkaloid | |
| buprenorphine | [no description available] | medium | 3 | 0 | morphinane alkaloid | delta-opioid receptor antagonist;
kappa-opioid receptor antagonist;
mu-opioid receptor agonist;
opioid analgesic |
| paroxetine | [no description available] | medium | 1 | 0 | aromatic ether;
benzodioxoles;
organofluorine compound;
piperidines | antidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor |
| trazodone | [no description available] | medium | 1 | 0 | monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
triazolopyridine | adrenergic antagonist;
antidepressant;
anxiolytic drug;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor |
| n-methyl-n-(tert-butyldimethylsilyl)trifluoroacetamide | [no description available] | medium | 1 | 0 | monocarboxylic acid amide;
N-silyl compound;
trifluoroacetamide | chromatographic reagent |
| trifluoroacetic acid | [no description available] | medium | 1 | 0 | fluoroalkanoic acid | human xenobiotic metabolite;
NMR chemical shift reference compound;
reagent |
| heroin | [no description available] | medium | 1 | 0 | morphinane alkaloid | mu-opioid receptor agonist;
opioid analgesic;
prodrug |
| chlordiazepoxide | [no description available] | medium | 1 | 0 | benzodiazepine | |
| midazolam | [no description available] | medium | 2 | 0 | imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound | anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative |
| alprazolam | [no description available] | medium | 1 | 0 | organochlorine compound;
triazolobenzodiazepine | anticonvulsant;
anxiolytic drug;
GABA agonist;
muscle relaxant;
sedative;
xenobiotic |
| bromazepam | [no description available] | medium | 1 | 0 | organic molecular entity | |
| cyamemazine | [no description available] | medium | 1 | 0 | phenothiazines | |
| n-methyl-3,4-methylenedioxyamphetamine | [no description available] | medium | 1 | 0 | amphetamines;
benzodioxoles | neurotoxin |
| methylene chloride | [no description available] | medium | 1 | 0 | chloromethanes;
volatile organic compound | carcinogenic agent;
polar aprotic solvent;
refrigerant |
| triazolam | [no description available] | medium | 2 | 0 | triazolobenzodiazepine | sedative |
| alpha-hydroxytriazolam | [no description available] | medium | 1 | 0 | triazolobenzodiazepine | |
| 4-hydroxytriazolam | [no description available] | medium | 1 | 0 | triazolobenzodiazepine | |
| 2,5-dihydroxybenzoic acid | [no description available] | medium | 1 | 0 | dihydroxybenzoic acid | EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite |
| phencyclidine | [no description available] | medium | 1 | 0 | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug |
| ketamine | [no description available] | medium | 1 | 0 | cyclohexanones;
monochlorobenzenes;
secondary amino compound | analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic |
| dextropropoxyphene | [no description available] | medium | 1 | 0 | 1-benzyl-3-(dimethylamino)-2-methyl-1-phenylpropyl propanoate | mu-opioid receptor agonist;
opioid analgesic |
| 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine | [no description available] | medium | 1 | 0 | | |
| fluorescamine | [no description available] | medium | 2 | 0 | | |
| cotinine | [no description available] | medium | 1 | 0 | N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid | antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite |
| nicotine | [no description available] | medium | 1 | 0 | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic |
| benzoylecgonine | [no description available] | medium | 1 | 0 | benzoate ester;
tropane alkaloid | epitope;
human xenobiotic metabolite;
marine xenobiotic metabolite;
plant metabolite |
| didesethylflurazepam | [no description available] | medium | 1 | 0 | 1,4-benzodiazepinone;
monofluorobenzenes;
organochlorine compound;
primary amino compound | anticonvulsant;
anxiolytic drug;
drug metabolite;
GABAA receptor agonist;
sedative |
| flurazepam | [no description available] | medium | 1 | 0 | 1,4-benzodiazepinone;
monofluorobenzenes;
organochlorine compound;
tertiary amino compound | anticonvulsant;
anxiolytic drug;
GABAA receptor agonist;
sedative |
| 1-hydroxymethylmidazolam | [no description available] | medium | 1 | 0 | aromatic primary alcohol;
imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound | drug metabolite;
human blood serum metabolite;
human urinary metabolite |
| cetyltrimethylammonium ion | [no description available] | medium | 1 | 0 | quaternary ammonium ion | |
| sodium azide | [no description available] | medium | 1 | 0 | inorganic sodium salt | antibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen |
| amphetamine | [no description available] | medium | 1 | 0 | primary amine | |
| methamphetamine | [no description available] | medium | 1 | 0 | amphetamines;
secondary amine | central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic |
| estazolam | [no description available] | medium | 1 | 0 | triazoles;
triazolobenzodiazepine | anticonvulsant;
anxiolytic drug;
GABA modulator |
| gyki 52466 | [no description available] | low | 0 | 0 | benzodiazepine | |
| prazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| sch 16134 | [no description available] | low | 0 | 0 | benzodiazepine | |
| telenzepine | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4-Methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| tetrazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| ketazolam | [no description available] | low | 0 | 0 | benzodiazepine | |
| doxefazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| pinazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| metaclazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| n-desmethylclobazam | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7-acetamidonitrazepam | [no description available] | low | 0 | 0 | benzodiazepine | |
| afdx 116 | [no description available] | low | 0 | 0 | benzodiazepine | |
| tifluadom | [no description available] | low | 0 | 0 | benzodiazepine | |
| afdx 384 | [no description available] | low | 0 | 0 | benzodiazepine | |
| aq-ra 741 | [no description available] | low | 0 | 0 | benzodiazepine | |
| auranthine | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4,7,8-Trimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| bms 214662 | [no description available] | low | 0 | 0 | benzenes;
benzodiazepine;
imidazoles;
nitrile;
sulfonamide;
thiophenes | antineoplastic agent;
apoptosis inducer;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor |
| 11-[2-[4-(2-aminoethyl)-1-piperazinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7-methyl-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 2,4-bis(4-methoxyphenyl)-4-methyl-1,2,3,5-tetrahydro-1,5-benzodiazepine | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7-chloro-5,10-dihydrothieno[3,4-b][1,5]benzodiazepin-4-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7,8-dimethyl-1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-4-phenyl-3H-1,5-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| l 364373 | [no description available] | low | 0 | 0 | benzodiazepine | |
| cycloanthranilylproline | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4-(2-hydroxyphenyl)-8,9-dimethyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 2-methyl-3-phenyl-3H-1,5-benzodiazepin-4-amine | [no description available] | low | 0 | 0 | benzodiazepine | |
| N-[3-(4-chlorophenyl)-2-methyl-3H-1,5-benzodiazepin-4-yl]benzamide | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7-chloro-5-(4-fluorophenyl)-4-(1-oxopropyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4-methyl-1-piperazinecarbodithioic acid [2-[(2-methyl-3-phenyl-3H-1,5-benzodiazepin-4-yl)amino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | benzodiazepine | |
| 2-ethyl-4-[[(3-methyl-2-benzofuranyl)-oxomethyl]amino]-1H-1,5-benzodiazepine-3-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4-[(2-chloro-6-fluorophenyl)-oxomethyl]-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| 7-chloro-4-[(2-fluorophenyl)-oxomethyl]-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| cfm 2 | [no description available] | low | 0 | 0 | benzodiazepine | |
| 4,8-dimethyl-1-(phenylmethyl)-3H-1,5-benzodiazepin-2-one | [no description available] | low | 0 | 0 | benzodiazepine | |
| gv 150013x | [no description available] | low | 0 | 0 | benzodiazepine | |
| l 365260 | [no description available] | low | 0 | 0 | benzodiazepine | |
| N-[2-[[11-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepin-8-yl]sulfonylamino]ethyl]carbamic acid tert-butyl ester | [no description available] | low | 0 | 0 | benzodiazepine | |
| aszonalenin | [no description available] | low | 0 | 0 | benzodiazepine;
zwitterion | |
| gsk525762a | [no description available] | low | 0 | 0 | benzodiazepine | |
| clozapine | [no description available] | low | 0 | 0 | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound | adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic |
| olanzapine | [no description available] | low | 0 | 0 | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine | antiemetic;
dopaminergic antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
serotonin uptake inhibitor |
| flumezapine | [no description available] | low | 0 | 0 | benzodiazepine | |
| ro 24-7429 | [no description available] | low | 0 | 0 | benzodiazepine | |
| desmethylolanzapine | [no description available] | low | 0 | 0 | benzodiazepine | |