Page last updated: 2024-09-28

alpha Mannosidase B Deficiency

Synonyms(9)

Synonym
Alpha-Mannosidase B Deficiency
Alpha-D-Mannosidosis
Mannosidosis, alpha B, Lysosomal
Mannosidosis, alpha B Lysosomal
Lysosomal Alpha B Mannosidosis
Alpha-Mannosidosis, Type I
alpha-Mannosidase Deficiency
alpha Mannosidase B Deficiency
Lysosomal alpha-D-Mannosidase Deficiency

Research

Studies (55)

TimeframeStudies, This Condition (%)All Conditions %
pre-199017 (30.91)23.3326
1990's26 (47.27)12.5806
2000's3 (5.45)18.1394
2010's8 (14.55)28.8240
2020's1 (1.82)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
ethanolamine0low10
busulfan0low10
2-propanol0low10
ketamine0low10
propofol0low10
sevoflurane0low10
thyroxine0low20
triiodothyronine0low20
sucrose0low10
lactose0low10
cycloheximide0low10
methylprednisolone0low10
2-naphthol0low10
alpha-aminopyridine0low10
mannose0low110
acetylglucosamine0low20
1-deoxynojirimycin0low10
7-amino-1-naphthol0low10
atracurium0low10
swainsonine0low110
cisatracurium0low10
8-amino-1,3,6-naphthalenetrisulfonic acid0low10
n-acetylglucosaminylasparagine0low10
glycogen0low10
n-acetylneuraminic acid0low20
glucosamine0low20
glycosides0low20
isomethyleugenol0low20
thiopental0low10
myelin basic protein0low20
dexmedetomidine0low10
cytochalasin b0low10
dolichols0low10
g(m2) ganglioside0low20
acid phosphatase0low10
thimerosal0low10
eye0low50

Protein Targets (489)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
glucocerebrosidase3003
Alpha-mannosidase0101
alpha-galactosidase1001
Trehalase 0101
lysosomal alpha-glucosidase preproprotein1001
Trehalase0101
Maltase-glucoamylase, intestinal0101
Trehalase 0101
Lysosomal acid glucosylceramidase0202
Alpha-galactosidase A0101
Alpha-glucosidase MAL620101
Lactase-phlorizin hydrolase0101
Lysosomal alpha-glucosidase0202
Beta-glucosidase A0101
Sucrase-isomaltase, intestinal0101
Alpha-1B adrenergic receptor0202
Sucrase-isomaltase, intestinal0101
Alpha-1D adrenergic receptor0202
Beta-glucosidase0101
Protein-lysine 6-oxidase0202
Alpha-mannosidase 20101
Glycogen debranching enzyme0101
Glycogen debranching enzyme0101
Alpha-glucosidase MAL320101
Alpha-1A adrenergic receptor0202
Oligo-1,6-glucosidase IMA10101
Alpha-glucosidase MAL120202
Oxysterols receptor LXR-beta0101
Spike glycoprotein2013
Alpha-amylase 0101
Trehalose synthase/amylase TreS0101
Lactase-phlorizin hydrolase 0101
Oxysterols receptor LXR-alpha0101
Neutral alpha-glucosidase AB0202
Ceramide glucosyltransferase0101
Lysosomal acid glucosylceramidase0101
Probable maltase-glucoamylase 20101
Beta-glucosidase 0101
Lysosomal alpha-glucosidase0101
Cytosolic beta-glucosidase0101
Non-lysosomal glucosylceramidase0101
Putative alpha-glucosidase0101
Luciferase2002
RAR-related orphan receptor gamma6006
GLI family zinc finger 37007
AR protein8008
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor7007
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha120012
peroxisome proliferator-activated receptor delta6006
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x6006
thyroid hormone receptor beta isoform 29009
nuclear factor erythroid 2-related factor 2 isoform 18008
DNA repair and recombination protein RadA0011
Voltage-dependent calcium channel gamma-2 subunit6006
Cellular tumor antigen p536006
Cytochrome P450 1A20101
Cytochrome P450 2A60101
Sulfotransferase 1A1 0001
Glutamate receptor 26006
Cytochrome P450 2A50101
Sulfotransferase 1E10001
Sulfotransferase 1A10001
Sulfotransferase 2A10001
hypoxia-inducible factor 1 alpha subunit3003
aldehyde dehydrogenase 1 family, member A15005
activating transcription factor 65005
thyroid hormone receptor beta isoform a6006
heat shock protein beta-14004
lamin isoform A-delta10100010
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Nrf22002
USP1 protein, partial7007
TDP1 protein7007
Smad34004
67.9K protein4004
chromobox protein homolog 17007
serine/threonine-protein kinase PLK13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)4004
geminin9009
DNA polymerase kappa isoform 13003
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10101
Guanine nucleotide-binding protein G1001
Putative glycosyltransferase WbgO0001
Cytochrome P450 3A40101
Cannabinoid receptor 10101
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
thyroid stimulating hormone receptor3003
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0101
Neutrophil cytosol factor 10101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0101
Kappa-type opioid receptor0011
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0011
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0101
NPYLR7B0011
Amine oxidase [flavin-containing] A 0011
Small conductance calcium-activated potassium channel protein 30112
Chain A, 2-oxoglutarate Oxygenase1001
15-lipoxygenase, partial2002
apical membrane antigen 1, AMA14004
thyroid stimulating hormone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 46006
EWS/FLI fusion protein3003
glucocorticoid receptor [Homo sapiens]6006
estrogen-related nuclear receptor alpha9009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lethal factor (plasmid)2002
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Bile salt export pump0404
Matrix metalloproteinase-90101
Disintegrin and metalloproteinase domain-containing protein 171001
Canalicular multispecific organic anion transporter 10303
interleukin 81001
glp-1 receptor, partial4004
pregnane X receptor2002
ATAD5 protein, partial2002
Fumarate hydratase2002
PPM1D protein2002
farnesoid X nuclear receptor4004
polyprotein2002
P531001
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
RPL19A0011
IDH14004
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor2002
cellular tumor antigen p53 isoform a3003
nuclear factor erythroid 2-related factor 2 isoform 24004
nuclear factor NF-kappa-B p105 subunit isoform 12002
ras-related protein Rab-9A2002
heat shock protein HSP 90-alpha isoform 20002
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 12002
transactivating tegument protein VP16 [Human herpesvirus 1]0101
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 14004
COUP transcription factor 2 isoform a0101
Gamma-aminobutyric acid receptor subunit pi44210
Transmembrane protease serine 20011
Glucose transporter0101
Hexose transporter 1 0101
Interferon beta5005
Procathepsin L0011
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Solute carrier family 2, facilitated glucose transporter member 10202
Gamma-aminobutyric acid receptor subunit beta-144210
Gamma-aminobutyric acid receptor subunit delta44210
Gamma-aminobutyric acid receptor subunit gamma-244311
Gamma-aminobutyric acid receptor subunit alpha-544210
Gamma-aminobutyric acid receptor subunit alpha-344210
Gamma-aminobutyric acid receptor subunit gamma-144210
Gamma-aminobutyric acid receptor subunit alpha-244210
Gamma-aminobutyric acid receptor subunit alpha-444210
Gamma-aminobutyric acid receptor subunit gamma-344210
Gamma-aminobutyric acid receptor subunit alpha-644210
Alpha-synuclein2002
Nuclear receptor ROR-gamma1001
Eukaryotic initiation factor 4A-I0101
Gamma-aminobutyric acid receptor subunit alpha-144311
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Gamma-aminobutyric acid receptor subunit beta-344210
Gamma-aminobutyric acid receptor subunit beta-244311
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
TAR DNA-binding protein 433003
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Hypoxia-inducible factor 1-alpha0101
GABA theta subunit44210
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0011
Gamma-aminobutyric acid receptor subunit epsilon44210
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0002
thioredoxin reductase4004
thioredoxin glutathione reductase1001
PINK11001
Parkin1001
bromodomain adjacent to zinc finger domain 2B3003
euchromatic histone-lysine N-methyltransferase 25005
neutrophil cytosol factor 10101
mitogen-activated protein kinase 12002
Solute carrier family 2, facilitated glucose transporter member 30101
Solute carrier family 2, facilitated glucose transporter member 40101
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
peripheral myelin protein 225005
Alpha-2A adrenergic receptor0112
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0112
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Histamine H2 receptor2002
Glutaminyl-peptide cyclotransferase0101
Chain A, Ferritin light chain3003
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
regulator of G-protein signaling 42002
arylsulfatase A1001
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor2002
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10224
Gamma-aminobutyric acid receptor subunit gamma-20325
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10303
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30325
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50224
Sodium- and chloride-dependent GABA transporter 20303
Sodium- and chloride-dependent GABA transporter 30303
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30224
Gamma-aminobutyric acid receptor subunit alpha-20224
Gamma-aminobutyric acid receptor subunit beta-20224
Sodium- and chloride-dependent betaine transporter0303
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40224
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0202
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60224
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30202
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0202
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 32002
Glutamate receptor ionotropic, NMDA 1 0202
Sodium channel protein type 4 subunit alpha0101
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, cellulase0011
Chain A, cellulase0011
Chain A, Galectin-30011
Chain A, Anti-tumor lectin0101
Galectin-30101
Galectin-90011
Galectin-80011
Beta-galactoside-binding lectin0101
Galectin-10113
Galectin-30112
Galectin-30113
Galectin-70011
Alpha 1,4 galactosyltransferase0001
Alpha-mannosidase 2C10202
Fucose-binding lectin PA-IIL0101
CD209 antigen0101
acetylcholinesterase2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nonstructural protein 11001
G4004
nuclear receptor subfamily 1, group I, member 22002
muscleblind-like protein 1 isoform 12002
Nuclear receptor subfamily 1 group I member 20022
HLA class I histocompatibility antigen, B alpha chain 4004
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Androgen receptor0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Inositol hexakisphosphate kinase 14004
Nuclear receptor subfamily 1 group I member 20011
cytochrome P450 2C9, partial4004
ATP-dependent phosphofructokinase2002
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
GLS protein2002
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
muscarinic acetylcholine receptor M11001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90001
5-hydroxytryptamine receptor 40202
Carbonic anhydrase 10101
Carbonic anhydrase 20213
Aldo-keto reductase family 1 member B10202
Gamma-aminobutyric acid receptor subunit alpha-10002
Gamma-aminobutyric acid receptor subunit beta-10002
Gamma-aminobutyric acid receptor subunit alpha-20002
Gamma-aminobutyric acid receptor subunit alpha-30002
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit alpha-40002
Gamma-aminobutyric acid receptor subunit gamma-20002
Prostaglandin G/H synthase 10101
Sodium-dependent noradrenaline transporter 0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 2B0202
Fatty-acid amide hydrolase 10202
UDP-glucuronosyltransferase 1A80001
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Carbonic anhydrase 90112
Chain A, Alpha-mannosidase Ii0101
Chain A, ALPHA-MANNOSIDASE II0101
Chain A, Alpha-mannosidase Ii0101
Lysosomal alpha-mannosidase0101
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA0202
Alpha-mannosidase 20101
Alpha-1,2-mannosidase family protein0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Glycoside hydrolase family 920101
Glycoside hydrolase family 920101
Alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase, putative0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Putative alpha-1,2-mannosidase0101
Alpha-1,2-mannosidase family protein0101
alpha-1,2-Mannosidase 0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, Cruzipain1001
phosphopantetheinyl transferase1001
Caspase 6, apoptosis-related cysteine peptidase0001
SMAD family member 21001
SMAD family member 31001
Microtubule-associated protein tau1001
hypothetical protein, conserved1001
cytochrome P450 2D61001
toll-like receptor 90101
caspase recruitment domain family, member 150101
thyrotropin-releasing hormone receptor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
vitamin D3 receptor isoform VDRA1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
histone deacetylase 9 isoform 31001
huntingtin isoform 21001
importin subunit beta-1 isoform 11001
neurotensin receptor type 10011
receptor-interacting serine/threonine-protein kinase 2 isoform 10101
flap endonuclease 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Integrin beta-31001
Integrin alpha-IIb1001
large T antigen0101
Beta lactamase (plasmid)0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10002
Prothrombin0011
Androgen receptor0101
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]