Page last updated: 2024-10-29

ketamine and Acathisia, Drug-Induced

ketamine has been researched along with Acathisia, Drug-Induced in 15 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
" This was reached in 74 cases with only one dose of ketamine, in 26 cases a second dose was needed, a same number needed nitrous oxide in addition and 9 times a second dose and nitrous oxide was given."3.69[Analgetic ketamine feasible in ambulance emergency care]. ( Ansem, RP; Foudraine, JF; Hartman, JA; Rutten, FL; van Loenen, E, 1994)
"Management of postoperative pain and emergence agitation following adenotonsillectomy in pediatrics has been a major challenge for anesthesiologists."2.78Ketamine improves postoperative pain and emergence agitation following adenotonsillectomy in children. A randomized clinical trial. ( Amin, A; Eghbal, MH; Sahmeddini, MA; Taregh, S, 2013)
" Eight patients developed adverse reactions, 3 of which required further evaluation in the emergency department."1.37Safety of deep sedation in an urban oral and maxillofacial surgery training program. ( Braidy, HF; Singh, P; Ziccardi, VB, 2011)
"Ketamine is a safe and effective sedative for emergency department procedures in children."1.31Predictors of adverse events with intramuscular ketamine sedation in children. ( Green, SM; Ho, M; Hummel, CB; Kuppermann, N; Rothrock, SG, 2000)
"Tachycardia was the most common physical examination finding."1.31Ketamine abusers presenting to the emergency department: a case series. ( Bayer, MJ; McKay, CA; Vieira, L; Weiner, AL, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's2 (13.33)18.2507
2000's5 (33.33)29.6817
2010's5 (33.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Roxas, N1
Ahuja, C1
Isom, J1
Wilkinson, ST1
Capurso, N1
Tan, D1
Xia, H1
Sun, S1
Wang, F1
Eghbal, MH1
Taregh, S1
Amin, A1
Sahmeddini, MA1
Higa, KK1
Ji, B1
Buell, MR1
Risbrough, VB1
Powell, SB1
Young, JW1
Geyer, MA1
Zhou, X1
Tsai, PS1
Hsu, YW1
Lin, CS1
Ko, YP1
Huang, CJ1
Dahmani, S1
Stany, I1
Brasher, C1
Lejeune, C1
Bruneau, B1
Wood, C1
Nivoche, Y1
Constant, I1
Murat, I1
Braidy, HF1
Singh, P1
Ziccardi, VB1
Green, SM2
Sherwin, TS1
Santiveri, X1
Moltò, L1
Rodríguez, C1
Sandín, F1
Vilaplana, J1
Castillo, J1
Brina, P1
Giuliano, G1
Migliarese, MC1
Montanari, C1
Pagnoni, B1
Ansem, RP1
Hartman, JA1
Foudraine, JF1
van Loenen, E1
Rutten, FL1
Marai, W1
Kuppermann, N1
Rothrock, SG1
Hummel, CB1
Ho, M1
Weiner, AL1
Vieira, L1
McKay, CA1
Bayer, MJ1
Venturini, AH1
Parietti, A1
Giménez, JC1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Check Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine. A Multi-Center, Randomized Double-Blind, Clinical Control Trial.[NCT02657031]Phase 454 participants (Actual)Interventional2016-03-17Completed
Prospective Cohort Study Evaluating Incidence and Correlation Between Pain and Emergence Delirium After Adenotonsillectomy in Preschool Children[NCT01096797]Phase 4150 participants (Actual)Interventional2009-11-30Completed
Caudal Versus Intravenous Magnesium Sulfate In The Prevention OF Emergence Agitation After Sevoflurane Anesthesia For Lower Abdominal Surgeries In Children.[NCT03846284]93 participants (Actual)Interventional2017-10-08Active, not recruiting
Effectivity of 0.5 mg/kg Propofol in the End of Anesthesia to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Inhalation Anesthesia[NCT03528954]54 participants (Actual)Interventional2018-05-31Completed
Changes of the Short Portable Mental Status Questionnaire (SPMSQ-E) After Ketamine Administration on Ophthalmic Surgery in Geriatric Population.[NCT02049411]Phase 280 participants (Actual)Interventional2013-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Anxiety

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum anxiety. A change of 0 mm corresponds to no change in anxiety level, and a negative value indicates worsening of the anxiety after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm33.7
Study Arm21.2

Headache Following Intervention

Reduction in 100 mm Visual Analog Scale (VAS) Score. Positive values represent a reduction in headache severity. The maximum possible change in VAS score is 100 mm, representing the complete relief of a maximally severe headache. A change of 0 mm corresponds to no change in headache severity, and a negative value indicates worsening of the headache after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm63.5
Study Arm43.5

Nausea

Reduction in 100 mm Visual Analog Scale (VAS) Score. The maximum possible change in VAS score is 100 mm, representing the complete relief of maximum nausea. A change of 0 mm corresponds to no change in nausea level, and a negative value indicates worsening of the nausea after the medication. (NCT02657031)
Timeframe: 0-60 minutes

Interventionmm (Mean)
Control Arm38.9
Study Arm22.9

The Number of Participants Experiencing Vomiting

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm2
Study Arm3

The Number of Patients Experiencing Restlessness

Yes/No (NCT02657031)
Timeframe: 0-60 minutes

Interventionparticipants (Number)
Control Arm3
Study Arm3

Reviews

2 reviews available for ketamine and Acathisia, Drug-Induced

ArticleYear
Effect of ancillary drugs on sevoflurane related emergence agitation in children undergoing ophthalmic surgery: a Bayesian network meta-analysis.
    BMC anesthesiology, 2019, 08-01, Volume: 19, Issue:1

    Topics: Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Anesthetics, Inhalation; Bayes Theo

2019
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010
Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies.
    British journal of anaesthesia, 2010, Volume: 104, Issue:2

    Topics: Akathisia, Drug-Induced; Analgesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics

2010

Trials

5 trials available for ketamine and Acathisia, Drug-Induced

ArticleYear
Ketamine improves postoperative pain and emergence agitation following adenotonsillectomy in children. A randomized clinical trial.
    Middle East journal of anaesthesiology, 2013, Volume: 22, Issue:2

    Topics: Adenoidectomy; Adolescent; Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Child; C

2013
Ketamine but not propofol provides additional effects on attenuating sevoflurane-induced emergence agitation in midazolam premedicated pediatric patients.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:11

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Dissociative; Anesthetics, Inhalat

2008
Incidence and severity of recovery agitation after ketamine sedation in young adults.
    The American journal of emergency medicine, 2005, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Analgesics; Anesthesia Recovery Period; Crying; Emergenc

2005
[Sedation and analgesia with propofol plus low-dose ketamine for retrobulbar block].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:9

    Topics: Aged; Aged, 80 and over; Akathisia, Drug-Induced; Ambulatory Surgical Procedures; Analgesics, Non-Na

2006
[Flunitrazepam (Ro 5-4200): a new benzodiazepinic derivative. Comparative double blind study with diazepam to control the psychomotor reactions of ketamine].
    Revista espanola de anestesiologia y reanimacion, 1977, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Anti-Anxiety Agents; Diazepam; Dilatation and Cure

1977

Other Studies

8 other studies available for ketamine and Acathisia, Drug-Induced

ArticleYear
A Potential Case of Acute Ketamine Withdrawal: Clinical Implications for the Treatment of Refractory Depression.
    The American journal of psychiatry, 2021, Volume: 178, Issue:7

    Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Hum

2021
Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.
    The international journal of neuropsychopharmacology, 2015, Jun-02, Volume: 18, Issue:11

    Topics: Akathisia, Drug-Induced; Animals; Cohort Studies; Excitatory Amino Acid Antagonists; Female; GABAerg

2015
Safety of deep sedation in an urban oral and maxillofacial surgery training program.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2011, Volume: 69, Issue:8

    Topics: Adjuvants, Anesthesia; Adult; Age Factors; Aggression; Akathisia, Drug-Induced; Ambulatory Surgical

2011
[General anesthesia with continuous-infusion ketamine].
    Minerva anestesiologica, 1980, Volume: 46, Issue:8

    Topics: Akathisia, Drug-Induced; Anesthesia, General; Anesthesia, Intravenous; Hemodynamics; Humans; Infusio

1980
[Analgetic ketamine feasible in ambulance emergency care].
    Nederlands tijdschrift voor geneeskunde, 1994, Nov-12, Volume: 138, Issue:46

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Akathisia, Drug-Induced; Child; Cognition Disorders; Eme

1994
Exaggerated psychomotor response to intravenous bolus dose administration of ketamine.
    Ethiopian medical journal, 1994, Volume: 32, Issue:2

    Topics: Adult; Akathisia, Drug-Induced; Asthma; Female; Humans; Injections, Intravenous; Ketamine; Uterine H

1994
Predictors of adverse events with intramuscular ketamine sedation in children.
    Annals of emergency medicine, 2000, Volume: 35, Issue:1

    Topics: Adolescent; Age Distribution; Airway Obstruction; Akathisia, Drug-Induced; Analysis of Variance; Ane

2000
Ketamine abusers presenting to the emergency department: a case series.
    The Journal of emergency medicine, 2000, Volume: 18, Issue:4

    Topics: Akathisia, Drug-Induced; Anesthetics, Dissociative; Anxiety; Chest Pain; Connecticut; Diagnosis, Dif

2000