Page last updated: 2024-10-29

ketamine and Adverse Drug Event

ketamine has been researched along with Adverse Drug Event in 36 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"Ketamine is frequently used in the management of refractory chronic pain."8.98[Ketamine and chronic pain: A narrative review of its efficacy and its adverse events]. ( Micallef, J; Morel, V; Pickering, G, 2018)
"Esketamine, the S-enantiomer of ketamine, has recently emerged as a therapy for treatment-resistant depression (TRD), showing both rapid antidepressant action and good efficacy and high safety."8.31Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study. ( Andriola, I; Barlati, S; Bassetti, R; Chiappini, S; Clerici, M; d'Andrea, G; De Filippis, S; Dell'Osso, B; Di Nicola, M; Martinotti, G; Pettorruso, M; Sensi, S; Vita, A, 2023)
"This multi-center, retrospective cohort study evaluated adult patients who received analgesic and sub-dissociative dose ketamine for the management of acute pain between May 5, 2018, and August 30, 2021, in 21 emergency departments at academic, community, and critical access hospitals across four states."8.31Efficacy of analgesic and sub-dissociative dose ketamine for acute pain in the emergency department. ( Beaudrie-Nunn, AN; Bellolio, F; Canterbury, EA; Mara, KC; Wieruszewski, ED; Woods, EJ, 2023)
"To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team."8.12Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022)
"Esketamine is the S-enantiomer of racemic ketamine and has been approved by the Food and Drug Administration for the management of treatment resistant depression, demonstrating effective and long-lasting benefits."8.12Association of intranasal esketamine, a novel 'standard of care' treatment and outcomes in the management of patients with treatment-resistant depression: protocol of a prospective cohort observational study of naturalistic clinical practice. ( Do, A; Giacobbe, P; Gutierrez, G; Hawken, E; Karthikeyan, G; Lam, RW; Milev, R; Ravindran, N; Rosenblat, J; Schaffer, A; Swainson, J; Vazquez, G, 2022)
"The xylazine/ketamine anesthesia test is widely used as a predictor of the emetic potential of pharmacological compounds in rats."7.91Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats. ( Bonassoli, VT; Heckman, PRA; Nelissen, E; Prickaerts, J; Suay, D; van Goethem, NP; van Hagen, BTJ; Wouters, C, 2019)
" The most common treatment-emergent adverse events associated with ketamine/esketamine are dissociation, anxiety, nausea, increased blood pressure, and headache."6.72Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. ( Cao, B; Ceban, F; Chau, EH; Gill, H; Ho, RC; Kratiuk, K; Kumar, A; Lee, JG; Lee, Y; Lin, K; Lipsitz, O; Lui, LMW; Mansur, RB; McIntyre, RS; Nasri, F; Rodrigues, NB; Rosenblat, JD; Subramaniapillai, M; Swainson, J, 2021)
" A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes."6.55Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017)
"Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist first developed as an anesthetic, has shown significant promise as a medication with rapid antidepressant properties in treatment-resistant depression."5.41The antidepressant actions of ketamine and its enantiomers. ( Henter, ID; Johnston, JN; Zarate, CA, 2023)
"In non-intubated general anesthesia, the combination of subclinical doses of esketamine and propofol did reduce circulatory and respiratory depression, injection pain, and other adverse effects, while the incidence of esketamine's own side effects such as neuropsychiatric reactions did not increase, and the combination of the two did not cause the occurrence of new and more serious adverse reactions, and the combination of the two was safe and effective."5.41Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis. ( Chen, H; Ding, X; Fu, Q; Li, P; Liu, Q; Xiang, G; Xu, L, 2023)
"A prospective, randomized, controlled, double-blind clinical trial to assess the effect of tramadol and ketamine, 50 mg, added to ropivacaine in brachial plexus anesthesia."5.19Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block? ( Senel, AC; Timurkaynak, A; Ukinc, O, 2014)
"Ketamine is frequently used in the management of refractory chronic pain."4.98[Ketamine and chronic pain: A narrative review of its efficacy and its adverse events]. ( Micallef, J; Morel, V; Pickering, G, 2018)
"Esketamine, the S-enantiomer of ketamine, has recently emerged as a therapy for treatment-resistant depression (TRD), showing both rapid antidepressant action and good efficacy and high safety."4.31Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study. ( Andriola, I; Barlati, S; Bassetti, R; Chiappini, S; Clerici, M; d'Andrea, G; De Filippis, S; Dell'Osso, B; Di Nicola, M; Martinotti, G; Pettorruso, M; Sensi, S; Vita, A, 2023)
"This multi-center, retrospective cohort study evaluated adult patients who received analgesic and sub-dissociative dose ketamine for the management of acute pain between May 5, 2018, and August 30, 2021, in 21 emergency departments at academic, community, and critical access hospitals across four states."4.31Efficacy of analgesic and sub-dissociative dose ketamine for acute pain in the emergency department. ( Beaudrie-Nunn, AN; Bellolio, F; Canterbury, EA; Mara, KC; Wieruszewski, ED; Woods, EJ, 2023)
"To report on an unusual case of ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion (SIADH) in an individual managed by an outpatient pain specialty team."4.12Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. ( Lau, A; van Bockxmeer, JJ; Varshney, V, 2022)
"Esketamine is the S-enantiomer of racemic ketamine and has been approved by the Food and Drug Administration for the management of treatment resistant depression, demonstrating effective and long-lasting benefits."4.12Association of intranasal esketamine, a novel 'standard of care' treatment and outcomes in the management of patients with treatment-resistant depression: protocol of a prospective cohort observational study of naturalistic clinical practice. ( Do, A; Giacobbe, P; Gutierrez, G; Hawken, E; Karthikeyan, G; Lam, RW; Milev, R; Ravindran, N; Rosenblat, J; Schaffer, A; Swainson, J; Vazquez, G, 2022)
"The xylazine/ketamine anesthesia test is widely used as a predictor of the emetic potential of pharmacological compounds in rats."3.91Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats. ( Bonassoli, VT; Heckman, PRA; Nelissen, E; Prickaerts, J; Suay, D; van Goethem, NP; van Hagen, BTJ; Wouters, C, 2019)
"Esketamine was approved for adults with treatment-resistant depression (TRD) in conjunction with an oral antidepressant, and for treating depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior."2.82Craving and addictive potential of esketamine as side effects? ( Orsolini, L; Salvi, V; Volpe, U, 2022)
" The most common treatment-emergent adverse events associated with ketamine/esketamine are dissociation, anxiety, nausea, increased blood pressure, and headache."2.72Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. ( Cao, B; Ceban, F; Chau, EH; Gill, H; Ho, RC; Kratiuk, K; Kumar, A; Lee, JG; Lee, Y; Lin, K; Lipsitz, O; Lui, LMW; Mansur, RB; McIntyre, RS; Nasri, F; Rodrigues, NB; Rosenblat, JD; Subramaniapillai, M; Swainson, J, 2021)
" Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture acute and longer-term side effects associated with repeated ketamine treatments."2.66Development of the Ketamine Side Effect Tool (KSET). ( Bayes, AJ; Dong, V; Fam, J; Fraguas, R; Gálvez, V; Glue, P; Loo, CK; Martin, D; McLoughlin, DM; McShane, R; Murrough, JW; Riva-Posse, P; Schoevers, R; Short, B; Vulovic, V; Zarate, CA, 2020)
" A literature review was performed to ascertain potential side effects and/or adverse events when using ketamine for analgesia purposes."2.55Ketamine for Pain Management-Side Effects & Potential Adverse Events. ( Allen, CA; Ivester, JR, 2017)
" Results Potential avenues investigated to minimise psychotomimetic effects associated with ketamine administration include the following: (1) altering dosing and infusion rates; (2) route of administration; (3) enantiomer choice; (4) co-administration with mood stabilisers of antipsychotics; and (5) use of alternative N-methyl-d-aspartate (NMDA)-modulating agents."2.55Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review. ( Cha, DS; Cooper, MD; Kakar, R; Lee, Y; McIntyre, RS; Rosenblat, JD, 2017)
"We conducted a systematic review and meta-analysis to evaluate the incidence of adverse events in the emergency department (ED) during procedural sedation in the paediatric population."2.53Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis. ( Anderson, JL; Barrionuevo, P; Bellolio, MF; Erwin, PJ; Gilani, WI; Hess, EP; Murad, MH; Puls, HA; Wang, Z, 2016)
"We recommend the Ketamine Side Effect Tool (KSET) as a comprehensive safety monitoring tool for acute and longer term side effects."1.72The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry. ( Bayes, A; Brunoni, AR; Fam, J; Galvez, V; Glue, P; Loo, CK; Martin, D; McLoughlin, DM; McShane, R; Murrough, JW; Parikh, S; Park, L; Riva-Posse, P; Schoevers, R; Short, B; Tor, PC; Veraart, J; Zarate, CA, 2022)
"Using the FDA Adverse Event Reporting System (FAERS) database (March 2019-March 2020), we analysed esketamine-related adverse events (AEs) to detect and characterize relevant safety signals."1.62Post-Marketing Safety Concerns with Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System. ( Barbui, C; Gastaldon, C; Kane, JM; Raschi, E; Schoretsanitis, G, 2021)
"Ketamine was the sole drug administered in 156/194 (80."1.62Is medicinal ketamine associated with urinary dysfunction issues? Assessment of both the European Medicines Agency (EMA) and the UK Yellow Card Scheme pharmacovigilance database-related reports. ( Castiglione, F; Chiappini, S; Salonia, A; Schifano, F; Schifano, N, 2021)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.33)18.7374
1990's0 (0.00)18.2507
2000's1 (2.78)29.6817
2010's13 (36.11)24.3611
2020's19 (52.78)2.80

Authors

AuthorsStudies
Chen, M1
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W2
Ding, D1
Kelly, R1
Morgan, RE1
van Staden, CJ1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Afshari, CA1
Hamadeh, HK1
Karakatsoulis, GN1
Tsapakis, EM1
Fountoulakis, KN1
van Bockxmeer, JJ1
Lau, A1
Varshney, V1
Bayes, A1
Short, B2
Zarate, CA3
Park, L1
Murrough, JW2
McLoughlin, DM2
Riva-Posse, P2
Schoevers, R2
Veraart, J1
Parikh, S1
Glue, P2
Fam, J2
McShane, R2
Galvez, V2
Martin, D2
Tor, PC1
Brunoni, AR1
Loo, CK2
Orsolini, L1
Salvi, V1
Volpe, U1
Vazquez, G1
Gutierrez, G1
Rosenblat, J1
Schaffer, A1
Swainson, J2
Karthikeyan, G1
Ravindran, N1
Lam, RW1
Do, A1
Giacobbe, P1
Hawken, E1
Milev, R1
Palamar, JJ1
Johnston, JN1
Henter, ID1
Chiappini, S2
d'Andrea, G1
De Filippis, S1
Di Nicola, M1
Andriola, I1
Bassetti, R1
Barlati, S1
Pettorruso, M1
Sensi, S1
Clerici, M1
Dell'Osso, B1
Vita, A1
Martinotti, G1
Beaudrie-Nunn, AN1
Wieruszewski, ED1
Woods, EJ1
Bellolio, F1
Mara, KC1
Canterbury, EA1
Chen, H1
Ding, X1
Xiang, G1
Xu, L1
Liu, Q1
Fu, Q1
Li, P1
Bozymski, KM1
Crouse, EL1
Titus-Lay, EN1
Ott, CA1
Nofziger, JL1
Kirkwood, CK1
Zhong, L1
Li, H1
Zhao, B1
Dong, V1
Vulovic, V1
Bayes, AJ1
Fraguas, R1
Gastaldon, C1
Raschi, E1
Kane, JM1
Barbui, C1
Schoretsanitis, G1
Schifano, N1
Castiglione, F1
Salonia, A1
Schifano, F1
Zhan, Z1
Wang, X1
Chen, Q1
Xiao, Z1
Zhang, B1
Meissner, K1
Henthorn, TK1
Ceban, F1
Rosenblat, JD2
Kratiuk, K1
Lee, Y2
Rodrigues, NB1
Gill, H1
Subramaniapillai, M1
Nasri, F1
Lui, LMW1
Lipsitz, O1
Kumar, A1
Lee, JG1
Chau, EH1
Cao, B1
Lin, K1
Ho, RC1
Mansur, RB1
McIntyre, RS2
Allen, CA1
Ivester, JR1
Hurwitz, J1
Pickering, G1
Morel, V1
Micallef, J1
Nelissen, E1
van Goethem, NP1
Bonassoli, VT1
Heckman, PRA1
van Hagen, BTJ1
Suay, D1
Wouters, C1
Prickaerts, J1
Senel, AC1
Ukinc, O1
Timurkaynak, A1
Cooper, MD1
Cha, DS1
Kakar, R1
Mora, AG1
Ganem, VJ1
Ervin, AT1
Maddry, JK1
Bebarta, VS1
Bellolio, MF1
Puls, HA1
Anderson, JL1
Gilani, WI1
Murad, MH1
Barrionuevo, P1
Erwin, PJ1
Wang, Z1
Hess, EP1
Hashimoto, K1
Wood, DM1
Greene, SL1
Dargan, PI1
Berde, C1
Cairns, B1
Wardell, WM1
Tsianco, MC1
Anavekar, SN1
Davis, HT1
Ndiritu, CG1
Enos, LR1
Robertson, DM1

Reviews

12 reviews available for ketamine and Adverse Drug Event

ArticleYear
[The role of ketamine in the treatment of treatment-resistant bipolar depression].
    Psychiatrike = Psychiatriki, 2021, Volume: 32, Issue:Supplement

    Topics: Antidepressive Agents; Bipolar Disorder; Depression; Depressive Disorder, Treatment-Resistant; Drug-

2021
Craving and addictive potential of esketamine as side effects?
    Expert opinion on drug safety, 2022, Volume: 21, Issue:6

    Topics: Adult; Bupropion; Craving; Depressive Disorder, Major; Drug-Related Side Effects and Adverse Reactio

2022
The antidepressant actions of ketamine and its enantiomers.
    Pharmacology & therapeutics, 2023, Volume: 246

    Topics: Antidepressive Agents; Depression; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine

2023
Analysis of the efficacy of subclinical doses of esketamine in combination with propofol in non-intubated general anesthesia procedures - a systematic review and meta-analysis.
    BMC anesthesiology, 2023, 07-21, Volume: 23, Issue:1

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Propof

2023
Esketamine: A Novel Option for Treatment-Resistant Depression.
    The Annals of pharmacotherapy, 2020, Volume: 54, Issue:6

    Topics: Administration, Intranasal; Administration, Oral; Adult; Antidepressive Agents; Blood Pressure; Depr

2020
Development of the Ketamine Side Effect Tool (KSET).
    Journal of affective disorders, 2020, 04-01, Volume: 266

    Topics: Chronic Pain; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Reproducibility of

2020
Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders.
    CNS drugs, 2021, Volume: 35, Issue:9

    Topics: Administration, Intranasal; Administration, Intravenous; Antidepressive Agents; Anxiety; Disease Man

2021
Ketamine for Pain Management-Side Effects & Potential Adverse Events.
    Pain management nursing : official journal of the American Society of Pain Management Nurses, 2017, Volume: 18, Issue:6

    Topics: Analgesics; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain; Pain Management

2017
[Ketamine and chronic pain: A narrative review of its efficacy and its adverse events].
    Therapie, 2018, Volume: 73, Issue:6

    Topics: Analgesics; Chronic Pain; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Pain Ma

2018
Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2017, Volume: 18, Issue:6

    Topics: Depressive Disorder, Major; Drug-Related Side Effects and Adverse Reactions; Excitatory Amino Acid A

2017
Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis.
    BMJ open, 2016, 06-15, Volume: 6, Issue:6

    Topics: Anesthetics, Dissociative; Child; Conscious Sedation; Drug-Related Side Effects and Adverse Reaction

2016
The eye and adverse drug effects. Some selected considerations.
    Minnesota medicine, 1972, Volume: 55, Issue:10

    Topics: Acetazolamide; Amyl Nitrite; Anesthesia; Chloramphenicol; Chloroquine; Contraceptives, Oral; Dexamet

1972

Trials

1 trial available for ketamine and Adverse Drug Event

ArticleYear
Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block?
    BioMed research international, 2014, Volume: 2014

    Topics: Adult; Amides; Analgesics, Opioid; Anesthesia; Brachial Plexus; Brachial Plexus Block; Double-Blind

2014

Other Studies

23 other studies available for ketamine and Adverse Drug Event

ArticleYear
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022, Volume: 69, Issue:5

    Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hyponatremia; Inappropriate ADH Syndrome; K

2022
The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry.
    Journal of affective disorders, 2022, 07-01, Volume: 308

    Topics: Administration, Intranasal; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Drug-Re

2022
Unintentional Ketamine Overdose in the Operating Room - Mixing Up the Ampules.
    AORN journal, 2022, Volume: 115, Issue:5

    Topics: Analgesics, Opioid; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Operating Roo

2022
Association of intranasal esketamine, a novel 'standard of care' treatment and outcomes in the management of patients with treatment-resistant depression: protocol of a prospective cohort observational study of naturalistic clinical practice.
    BMJ open, 2022, 09-01, Volume: 12, Issue:9

    Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resist

2022
Adverse drug effects as a deterrent against willingness to use in the future among nightclub/festival attendees.
    Drug and alcohol review, 2023, Volume: 42, Issue:6

    Topics: Adult; Drug-Related Side Effects and Adverse Reactions; Holidays; Humans; Illicit Drugs; Ketamine; M

2023
Esketamine in treatment-resistant depression patients comorbid with substance-use disorder: A viewpoint on its safety and effectiveness in a subsample of patients from the REAL-ESK study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2023, Volume: 74

    Topics: Administration, Intranasal; Adult; Antidepressive Agents; Comorbidity; Depression; Depressive Disord

2023
Efficacy of analgesic and sub-dissociative dose ketamine for acute pain in the emergency department.
    The American journal of emergency medicine, 2023, Volume: 70

    Topics: Acute Pain; Adult; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug-Related Side Effects an

2023
Comparison of Ketamine Alone and Subanesthetic Dose of Ketamine-Fentanyl for Regional Anesthesia in Children.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2020, Volume: 30, Issue:1

    Topics: Administration, Intravenous; Analgesia; Anesthesia, Intravenous; Child; Child, Preschool; Drug-Relat

2020
Post-Marketing Safety Concerns with Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System.
    Psychotherapy and psychosomatics, 2021, Volume: 90, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Drug-Related Side Effects and Adverse Reactions; Female; Hu

2021
Is medicinal ketamine associated with urinary dysfunction issues? Assessment of both the European Medicines Agency (EMA) and the UK Yellow Card Scheme pharmacovigilance database-related reports.
    Lower urinary tract symptoms, 2021, Volume: 13, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Drug-Related Side Effects and Adverse Reactions; Humans; Ke

2021
Comparative efficacy and side-effect profile of ketamine and esketamine in the treatment of unipolar and bipolar depression: protocol for a systematic review and network meta-analysis.
    BMJ open, 2021, 02-12, Volume: 11, Issue:2

    Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Humans; Ketamine; Meta-Analysis a

2021
How relevant is stereoselectivity to the side-effects of ketamine?
    British journal of anaesthesia, 2021, Volume: 127, Issue:1

    Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Iatrogenic Disease; Ketamine; Stereoisomeri

2021
Can We Finally Dispense With Ketamine's Many Myths?
    The Journal of emergency medicine, 2018, Volume: 54, Issue:5

    Topics: Anesthetics, Dissociative; Antidepressive Agents; Drug-Related Side Effects and Adverse Reactions; E

2018
Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats.
    Neuroscience letters, 2019, 04-23, Volume: 699

    Topics: Anesthesia; Animals; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions;

2019
En Route Use of Analgesics in Nonintubated, Critically Ill Patients Transported by U.S. Air Force Critical Care Air Transport Teams.
    Military medicine, 2016, Volume: 181, Issue:5 Suppl

    Topics: Adult; Aerospace Medicine; Afghan Campaign 2001-; Air Ambulances; Analgesics; Critical Care; Critica

2016
Detrimental Side Effects of Repeated Ketamine Infusions in the Brain.
    The American journal of psychiatry, 2016, 10-01, Volume: 173, Issue:10

    Topics: Brain; Depressive Disorder, Treatment-Resistant; Drug-Related Side Effects and Adverse Reactions; Hu

2016
Five-year trends in self-reported recreational drugs associated with presentation to a UK emergency department with suspected drug-related toxicity.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2013, Volume: 20, Issue:4

    Topics: Amphetamine-Related Disorders; Cocaine-Related Disorders; Drug-Related Side Effects and Adverse Reac

2013
Developmental pharmacology across species: promise and problems.
    Anesthesia and analgesia, 2000, Volume: 91, Issue:1

    Topics: Adult; Age Factors; Analgesics; Anesthetics; Animals; Animals, Laboratory; Animals, Newborn; Brain;

2000
Postmarketing surveillance of new drugs: II. Case studies.
    Journal of clinical pharmacology, 1979, Volume: 19, Issue:4

    Topics: Azauridine; Bacteriuria; Contraceptives, Oral; Costs and Cost Analysis; Double-Blind Method; Drug-Re

1979
Adverse reactions to drugs in a veterinary hospital.
    Journal of the American Veterinary Medical Association, 1977, Aug-15, Volume: 171, Issue:4

    Topics: Amphotericin B; Anaphylaxis; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Chloral Hydrate;

1977