ketamine has been researched along with Amnesia, Anterograde in 1 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Amnesia, Anterograde: Loss of the ability to form new memories beyond a certain point in time. This condition may be organic or psychogenic in origin. Organically induced anterograde amnesia may follow CRANIOCEREBRAL TRAUMA; SEIZURES; ANOXIA; and other conditions which adversely affect neural structures associated with memory formation (e.g., the HIPPOCAMPUS; FORNIX (BRAIN); MAMMILLARY BODIES; and ANTERIOR THALAMIC NUCLEI). (From Memory 1997 Jan-Mar;5(1-2):49-71)
| Excerpt | Relevance | Reference |
|---|---|---|
| "At 5 min, immediate recall, anterograde amnesia, retention in primary memory, short-term storage capacity, and intelligence quotient were less reduced after the isomers than racemic ketamine." | 2.70 | Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers. ( Durieux, ME; Himmelseher, S; Pfenninger, EG, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pfenninger, EG | 1 |
| Durieux, ME | 1 |
| Himmelseher, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Low Doses of Ketamine on Postoperative Quality of Recovery After Total Intravenous Anesthesia[NCT02571153] | Phase 4 | 135 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of stay at postanesthesia recovery room (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Saline Group | 82.9 |
| Ketamine 0.2 | 84.5 |
| Ketamine 0.4 | 86 |
Morphine consumption (mg) at PACU (about 90 to 120 minutes) (NCT02571153)
Timeframe: During the stay at postanesthesia recovery room (about 90 to 120 minutes)
| Intervention | mg (Mean) |
|---|---|
| Saline Group | 1.6 |
| Ketamine 0.2 | 0.9 |
| Ketamine 0.4 | 1.1 |
Occurrence of pain at the PACU. Average Pain will be calculated. The pain score will be evaluated using a 0-10 numeric pain rating scale, where zero mean no pain and 10 the worst imaginable pain. (NCT02571153)
Timeframe: 90 minutes postanesthesia at recovery room
| Intervention | units on a scale (Mean) |
|---|---|
| Saline Group | 3.8 |
| Ketamine 0.2 | 2.6 |
| Ketamine 0.4 | 2.8 |
Percentage of participants with postoperative nausea and vomiting at the PACU and during the hospital ward stay (NCT02571153)
Timeframe: 24 hours
| Intervention | percentage of participants (Number) |
|---|---|
| Saline Group | 30.8 |
| Ketamine 0.2 | 29.7 |
| Ketamine 0.4 | 39.5 |
Percentage of Participants with Tramadol during the ward stay (NCT02571153)
Timeframe: 24 hours
| Intervention | percentage of participants (Number) |
|---|---|
| Saline Group | 5.1 |
| Ketamine 0.2 | 10.8 |
| Ketamine 0.4 | 13.9 |
Quality of postoperative functional recovery assessed by the questionnaire QoR40 The quality of postoperative functional recovery was assessed by the QoR-40 questionnaire, which assesses five dimensions of recovery (physical comfort - 12 items; emotional state - 7 items; physical independence - 5 items; physiological support - 7 items; and pain - 7 items). Each item was rated on a five-point Likert scale: none of the time, some of the time, usually, most of the time, and all the time. The total score on the QoR-40 ranges from 40 (poorest quality of recovery) to 200 (best quality of recovery). The QoR-40 was administered by a blind investigator 24 hours after surgery. (NCT02571153)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Saline Group | 187.8 |
| Ketamine 0.2 | 189.6 |
| Ketamine 0.4 | 186.8 |
"The severity of postoperative pain was rated the higher score of pain (NRS) during the hospital ward stay.~Pain was evaluated using a 0-10 numeric pain rating scale (NRS), where zero meant no pain and 10 the worst imaginable pain." (NCT02571153)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Saline Group | 3.2 |
| Ketamine 0.2 | 2.8 |
| Ketamine 0.4 | 3.6 |
1 trial available for ketamine and Amnesia, Anterograde
| Article | Year |
|---|---|
Cognitive impairment after small-dose ketamine isomers in comparison to equianalgesic racemic ketamine in human volunteers.
Topics: Adult; Affect; Amnesia, Anterograde; Cognition Disorders; Cross-Over Studies; Double-Blind Method; E | 2002 |