Page last updated: 2024-10-29

ketamine and Hypothermia

ketamine has been researched along with Hypothermia in 31 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.

Research Excerpts

ExcerptRelevanceReference
"Dogs in which anesthesia was induced with a benzodiazepine plus propofol or ketamine became hypothermic; the extent of hypothermia was more profound for the propofol combination."9.22Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy. ( Bornkamp, JL; DiGangi, BA; Harrison, K; Isaza, NM; Pablo, L; Robertson, S, 2016)
"Core hypothermia during the first hour of anesthesia was less after induction of anesthesia with ketamine than propofol."9.09Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. ( Ikeda, T; Kazama, T; Niwa, K; Sato, S; Sessler, DI; Shimada, C; Toriyama, S, 2001)
"Although ketamine administration decreased the severity of hypotension and acidosis in endotoxemic rats, ketamine administration may not have additive beneficial antiinflammatory effects during hypothermia."7.72The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Takemoto, Y; Taniguchi, T; Yamamoto, K, 2004)
"Mild hypothermia is a common complication during spinal anesthesia and may induce a serious adverse outcome."6.71Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol. ( Kinoshita, T; Ogawa, R; Shimada, Y; Suzuki, M, 2004)
"Ketamine was used in 63/79 patients (80%)."5.56Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine. ( Ciccotto, G; Iwuchukwu, IO; Khan, F; Khandker, N; McGrade, H; Menon, U; Poongkunran, M; Ramsay, E; Sabharwal, V; Talahma, M, 2020)
" Cardiopulmonary instability was more common, and hypothermia was less common in the sedation groups of pentazocine/midazolam and fentanyl/midazolam, compared to the general anesthesia group of air/oxygen/sevoflurane (AOS)."5.41Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review. ( Arvanitaki, Z; Gavriilidou, A; Haidich, AB; Mataftsi, A; Seliniotaki, AK; Ziakas, N, 2023)
"Dogs in which anesthesia was induced with a benzodiazepine plus propofol or ketamine became hypothermic; the extent of hypothermia was more profound for the propofol combination."5.22Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy. ( Bornkamp, JL; DiGangi, BA; Harrison, K; Isaza, NM; Pablo, L; Robertson, S, 2016)
"Core hypothermia during the first hour of anesthesia was less after induction of anesthesia with ketamine than propofol."5.09Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. ( Ikeda, T; Kazama, T; Niwa, K; Sato, S; Sessler, DI; Shimada, C; Toriyama, S, 2001)
" Here we compared the effects of two anaesthetic reagents-a ketamine/xylazine combination, and tribromoethanol (Avertin)-on the rates of implantation and development to term of mouse zygotes transferred into the oviducts of CD-1 foster mothers, and evaluated whether hypothermia caused by anaesthetics after the ET operation could be overcome by postoperative incubation of the foster mothers."3.72Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse. ( Bagis, H; Dinnyes, A; Odaman Mercan, H, 2004)
"8% used inhalants (particularly isoflurane) for anesthesia, and ketamine, propofol, and butorphanol were the most commonly used injectable agents."3.72Evaluation of the use of anesthesia and analgesia in reptiles. ( Read, MR, 2004)
"Although ketamine administration decreased the severity of hypotension and acidosis in endotoxemic rats, ketamine administration may not have additive beneficial antiinflammatory effects during hypothermia."3.72The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Takemoto, Y; Taniguchi, T; Yamamoto, K, 2004)
" Both ASP and GLU produced a hyperthermic response in all animals, including those in which hypothermia was induced by reserpine."3.69Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats. ( Gupta, MC; Singh, J, 1997)
"Mild hypothermia is a common complication during spinal anesthesia and may induce a serious adverse outcome."2.71Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol. ( Kinoshita, T; Ogawa, R; Shimada, Y; Suzuki, M, 2004)
"Ketamine was used in 63/79 patients (80%)."1.56Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine. ( Ciccotto, G; Iwuchukwu, IO; Khan, F; Khandker, N; McGrade, H; Menon, U; Poongkunran, M; Ramsay, E; Sabharwal, V; Talahma, M, 2020)
"Morphine has long been known to have potent effects on body temperature."1.31Involvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in mice. ( Akpolat, M; Dokmeci, D; Dokmeci, I; Dost, T; Karadag, CH; Ulugol, A, 2000)
"In studies of experimentally induced retrograde amnesia (RA), as the interval between training and the amnestic treatment is lengthened, amnesia decreases (4)."1.30Ketaset-Rompun extends the temporal gradient for hypothermia-induced retrograde amnesia. ( Metzger, MM; Riccio, DC, 1999)
"Halothane was most effective in producing anaesthesia in Monodelphis domestica."1.27An evaluation of three anaesthetic regimes in the gray short-tailed opossum (Monodelphis domestica). ( Bowman, TA; Drozdowicz, CK; Keller, LS; Lang, CM; Rice, L, 1988)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19903 (9.68)18.7374
1990's4 (12.90)18.2507
2000's11 (35.48)29.6817
2010's9 (29.03)24.3611
2020's4 (12.90)2.80

Authors

AuthorsStudies
Bailey, KT1
Jantre, SR1
Lawrence, FR1
Hankenson, FC1
Del Valle, JM1
Gavriilidou, A1
Seliniotaki, AK1
Arvanitaki, Z1
Ziakas, N1
Haidich, AB1
Mataftsi, A1
Eshar, D1
Beaufrère, H1
Sabharwal, V1
Poongkunran, M1
Talahma, M1
Iwuchukwu, IO1
Ramsay, E1
Khan, F1
Menon, U1
Ciccotto, G1
Khandker, N1
McGrade, H1
Rufiange, M1
Leung, VSY1
Simpson, K1
Pang, DSJ1
Tsukamoto, A2
Konishi, Y1
Kawakami, T1
Koibuchi, C1
Sato, R1
Kanai, E1
Inomata, T2
Niino, N1
Sakamoto, M1
Ohtani, R1
Vujović, KS1
Vučković, S1
Đurović, A1
Knežević, NN1
Prostran, M1
Murphy, TJ1
Murnane, KS1
Lawthaweesawat, C1
Harris, R1
Isara, W1
Pongpirul, K1
Slater, CA1
Jackson, A1
Muldoon, PP1
Dawson, A1
O'Brien, M1
Soll, LG1
Abdullah, R1
Carroll, FI1
Tapper, AR1
Miles, MF1
Banks, ML1
Bettinger, JC1
Damaj, IM1
Bornkamp, JL1
Robertson, S1
Isaza, NM1
Harrison, K1
DiGangi, BA1
Pablo, L1
Neves, G1
Antonio, CB1
Betti, AH1
Pranke, MA1
Fraga, CA1
Barreiro, EJ1
Noël, F1
Rates, SM1
Sakamoto, T1
Kawaguchi, M1
Kakimoto, M1
Inoue, S1
Takahashi, M1
Furuya, H1
Bagis, H1
Odaman Mercan, H1
Dinnyes, A1
Read, MR1
Taniguchi, T1
Kanakura, H1
Takemoto, Y1
Yamamoto, K1
Stegmann, GF1
Kinoshita, T1
Suzuki, M1
Shimada, Y1
Ogawa, R1
Sharma, AK1
Kumar, N1
Dimri, U1
Hoque, M1
Maiti, SK1
Gupta, OP1
Shahi, A1
Johnston, NA1
Bosgraaf, C1
Cox, L1
Reichensperger, J1
Verhulst, S1
Patten, C1
Toth, LA1
Bansinath, M1
Nivarthi, RN1
Turndorf, H1
Singh, J1
Gupta, MC1
Stoskopf, MK1
Spelman, LH1
Sumner, PW1
Redmond, DP1
Jochem, WJ1
Levine, JF1
Metzger, MM1
Riccio, DC1
Ulugol, A1
Dost, T1
Dokmeci, D1
Akpolat, M1
Karadag, CH1
Dokmeci, I1
Ikeda, T1
Kazama, T1
Sessler, DI1
Toriyama, S1
Niwa, K1
Shimada, C1
Sato, S1
Bruins Slot, LA1
Tarayre, JP1
Koek, W1
Ribet, JP1
Colpaert, FC1
Waterman, A1
Keller, LS1
Drozdowicz, CK1
Rice, L1
Bowman, TA1
Lang, CM1
Fahim, I1
Ismail, M1
Osman, OH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder - Fear of Harm Phenotype[NCT05209217]20 participants (Anticipated)Observational2019-06-04Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for ketamine and Hypothermia

ArticleYear
Safety profile of anesthetic modalities during laser treatment for retinopathy of prematurity: a systematic review.
    Journal of perinatology : official journal of the California Perinatal Association, 2023, Volume: 43, Issue:6

    Topics: Anesthetics; Child; Fentanyl; Humans; Hypothermia; Infant; Infant, Newborn; Ketamine; Lasers; Midazo

2023

Trials

4 trials available for ketamine and Hypothermia

ArticleYear
Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy.
    American journal of veterinary research, 2016, Volume: 77, Issue:4

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Benzodiazepines; Blood Pressure; Body Temperature; Dog

2016
Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2004, Volume: 71, Issue:2

    Topics: Adult; Aged; Anesthesia, Spinal; Anti-Infective Agents; Body Temperature; Female; Humans; Hypothermi

2004
Strategies for refinement of abdominal device implantation in mice: strain, carboxymethylcellulose, thermal support, and atipamezole.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2007, Volume: 46, Issue:2

    Topics: Abdomen; Anesthetics; Anesthetics, Combined; Animals; Body Temperature; Carboxymethylcellulose Sodiu

2007
Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia.
    Anesthesia and analgesia, 2001, Volume: 93, Issue:4

    Topics: Adult; Anesthesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Body Temperature; Female; He

2001

Other Studies

26 other studies available for ketamine and Hypothermia

ArticleYear
Evaluation of Active Warming and Surgical Draping for Perioperative Thermal Support in Laboratory Mice.
    Journal of the American Association for Laboratory Animal Science : JAALAS, 2022, 09-01, Volume: 61, Issue:5

    Topics: Animals; Body Temperature; Hypothermia; Ketamine; Mice; Plastics; Water; Xylazine

2022
Anesthetic effects of dexmedetomidine-ketamine-midazolam administered intramuscularly in five-striped palm squirrels (
    American journal of veterinary research, 2019, Volume: 80, Issue:12

    Topics: Anesthesia; Anesthetics; Animals; Dexmedetomidine; Female; Heart Rate; Hypothermia; Ketamine; Male;

2019
Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine.
    Epilepsy & behavior : E&B, 2020, Volume: 105

    Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Disease Management; Female; Hum

2020
Pre-warming following premedication limits hypothermia before and during anesthesia in Sprague-Dawley rats
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2021, Volume: 85, Issue:2

    Topics: Adjuvants, Anesthesia; Analgesics; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals;

2021
Pharmacological properties of various anesthetic protocols in 10-day-old neonatal rats.
    Experimental animals, 2017, Oct-30, Volume: 66, Issue:4

    Topics: Anesthesia; Anesthetics, Combined; Animals; Animals, Newborn; Butorphanol; Dose-Response Relationshi

2017
The validity of anesthetic protocols for the surgical procedure of castration in rats.
    Experimental animals, 2018, Jul-30, Volume: 67, Issue:3

    Topics: Administration, Inhalation; Anesthesia; Anesthetics; Animal Experimentation; Animals; Bradycardia; B

2018
Inhibition of neuronal nitric oxide synthase attenuate the hypothermic effect of ketamine-magnesium sulfate combination in rats.
    Journal of thermal biology, 2018, Volume: 74

    Topics: Animals; Body Temperature; Enzyme Inhibitors; Hypothermia; Ketamine; Magnesium Sulfate; Male; NG-Nit

2018
The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice.
    European journal of pharmacology, 2019, Jan-05, Volume: 842

    Topics: Animals; Azepines; Body Temperature; Hypothermia; Indoles; Ketamine; Male; Mice; Receptor, Serotonin

2019
Prehospital Care of the 13 Hypothermic, Anesthetized Patients in the Thailand Cave Rescue.
    The New England journal of medicine, 2019, 04-04, Volume: 380, Issue:14

    Topics: Anesthetics, Dissociative; Caves; Emergency Medical Services; Humans; Hypothermia; Ketamine; Male; R

2019
Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Body Temperature; Central Nervous Syst

2016
New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia.
    Behavioural brain research, 2013, Jan-15, Volume: 237

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Barbiturates

2013
The effect of hypothermia on myogenic motor-evoked potentials to electrical stimulation with a single pulse and a train of pulses under propofol/ketamine/fentanyl anesthesia in rabbits.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:6

    Topics: Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Gas Analysi

2003
Exposure to warmer postoperative temperatures reduces hypothermia caused by anaesthesia and significantly increases the implantation rate of transferred embryos in the mouse.
    Laboratory animals, 2004, Volume: 38, Issue:1

    Topics: Anesthetics; Animals; Embryo Implantation; Embryo Transfer; Embryonic and Fetal Development; Ethanol

2004
Evaluation of the use of anesthesia and analgesia in reptiles.
    Journal of the American Veterinary Medical Association, 2004, Feb-15, Volume: 224, Issue:4

    Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Butorphanol; Humans; Hypothermi

2004
The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:4

    Topics: Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Te

2004
Midazolam/ketamine induction and isoflurane maintenance of anaesthesia in a 2-month-old, hand-raised African buffalo (Syncerus caffer).
    Journal of the South African Veterinary Association, 2004, Volume: 75, Issue:1

    Topics: Anesthetics, Combined; Anesthetics, Inhalation; Animals; Buffaloes; Hypnotics and Sedatives; Hypoten

2004
Romifidine-ketamine anaesthesia in atropine and triflupromazine pre-medicated buffalo calves.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2004, Volume: 51, Issue:9-10

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics, Dissociative; Animals; Atropine; Bradycardia; Buffal

2004
Role of nitric oxide-mediated signal transduction in hypothermia induced by intravenous anesthetics.
    Annals of the New York Academy of Sciences, 1997, Mar-15, Volume: 813

    Topics: Anesthetics, Intravenous; Animals; Cerebellum; Cyclic GMP; Hypothermia; Ketamine; Mice; Nitric Oxide

1997
Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
    Indian journal of physiology and pharmacology, 1997, Volume: 41, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Analgesia; Analgesics, Opioid; Animals; Aspartic Acid; Body Temperatur

1997
The impact of water temperature on core body temperature of North American river otters (Lutra canadensis) during simulated oil spill recovery washing protocols.
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 1997, Volume: 28, Issue:4

    Topics: Aerosols; Anesthesia; Anesthetics, Dissociative; Animals; Body Temperature; Detergents; Drug Combina

1997
Ketaset-Rompun extends the temporal gradient for hypothermia-induced retrograde amnesia.
    Physiology & behavior, 1999, Volume: 66, Issue:5

    Topics: Adrenergic alpha-Agonists; Amnesia, Retrograde; Analysis of Variance; Anesthetics, Dissociative; Ani

1999
Involvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:5

    Topics: Analgesics, Opioid; Animals; Body Temperature Regulation; Enzyme Inhibitors; Excitatory Amino Acid A

2000
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:4

    Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag

2002
Accidental hypothermia during anaesthesia in dogs and cats.
    The Veterinary record, 1975, Apr-05, Volume: 96, Issue:14

    Topics: Alfaxalone Alfadolone Mixture; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals;

1975
An evaluation of three anaesthetic regimes in the gray short-tailed opossum (Monodelphis domestica).
    Laboratory animals, 1988, Volume: 22, Issue:3

    Topics: Anesthesia; Animals; Halothane; Hypothermia; Ketamine; Opossums; Pentobarbital; Xylazine

1988
Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat.
    British journal of pharmacology, 1973, Volume: 48, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Ergotamine;

1973