Page last updated: 2024-10-29

ketamine and Asystole

ketamine has been researched along with Asystole in 18 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
" The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of asphyxial cardiac arrest (ACA)."7.91The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest. ( Akhatov, N; Baigenzhin, A; Barlow, N; Dahl, V; Karibekov, T; Kondratiev, T; Konkayev, A; Konkayeva, M; Kuklin, V; Tveita, T, 2019)
" Of the nine patients who received ketamine, two had documented cardiac events; one remained clinically stable and the other developed multiple arrhythmias, including recurrent episodes of asystole."7.88Ketamine infusion for refractory status epilepticus: A case report of cardiac arrest. ( Farrokh, S; Geocadin, R; Koffman, L; Lewin, J; Yan Yiu, H; Ziai, W, 2018)
"Ketamine appears to be a safe anesthetic option for children with PAH."5.36Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010)
" There was no demonstrable difference in post-induction hypotension between ketamine-based and midazolam-based PHEA."4.12Cardiovascular complications of prehospital emergency anaesthesia in patients with return of spontaneous circulation following medical cardiac arrest: a retrospective comparison of ketamine-based and midazolam-based induction protocols. ( Keeliher, C; Khan-Cheema, H; King, C; Lewinsohn, A; McLachlan, S; Sherren, P; Sherrin, J, 2022)
" The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of asphyxial cardiac arrest (ACA)."3.91The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest. ( Akhatov, N; Baigenzhin, A; Barlow, N; Dahl, V; Karibekov, T; Kondratiev, T; Konkayev, A; Konkayeva, M; Kuklin, V; Tveita, T, 2019)
" Of the nine patients who received ketamine, two had documented cardiac events; one remained clinically stable and the other developed multiple arrhythmias, including recurrent episodes of asystole."3.88Ketamine infusion for refractory status epilepticus: A case report of cardiac arrest. ( Farrokh, S; Geocadin, R; Koffman, L; Lewin, J; Yan Yiu, H; Ziai, W, 2018)
"Cardiac arrest is a leading cause of death and disability worldwide."1.46General anesthetics protects against cardiac arrest-induced brain injury by inhibiting calcium wave propagation in zebrafish. ( Du, JL; Wang, B; Wang, YW; Xu, DJ; Zhao, X; Zheng, Y, 2017)
"Three patients experienced cardiac arrest without death, all associated with laryngospasm."1.43Procedural Sedation Outside of the Operating Room Using Ketamine in 22,645 Children: A Report From the Pediatric Sedation Research Consortium. ( Chumpitazi, CE; Grunwell, JR; Kamat, PP; McCracken, CE; Roback, MG; Scherrer, PD; Stockwell, JA; Stormorken, AG; Travers, C, 2016)
"Asystolic cardiac arrest for 8 minutes was induced in 73 rats with a mixture of potassium chloride and esmolol."1.42Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model? ( Bendel, S; Grandgirard, D; Haenggi, M; Jakob, SM; Leib, SL; Pereira, A; Putzu, A; Schlickeiser, J; Springe, D; Takala, J, 2015)
"Two patients (10%) experienced a cardiac arrest, and both required unplanned admission to the authors' pediatric intensive care unit (PICU) postoperatively."1.37General anesthesia for children with severe heart failure. ( Haynes, SR; Murphy, TW; Ranger, MR; Smith, JH, 2011)
"Ketamine appears to be a safe anesthetic option for children with PAH."1.36Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine. ( Bair, E; Bratton, SL; Feinstein, JA; Hammer, GB; Kamra, K; Kuan, CC; Maan, H; Ramamoorthy, C; Williams, GD, 2010)
"midazolam was 43."1.31Intravenous midazolam significantly enhances the lethal effect of thiopental but not that of ketamine in mice. ( Ben-Shlomo, I; Hadash, O; Katz, Y; Rosenbaum, A, 2001)
"Asphyxial cardiopulmonary arrest was induced and, after and 8 min cardiac arrest nonintervention interval, a standardized protocol of manual CPR with mechanical ventilation was performed."1.30Anesthetic regimen effects on a pediatric porcine model of asphyxial arrest. ( Ginn, A; Jasani, MS; Nadkarni, VM; Salzman, SK; Tice, LL, 1997)
"Unexpected cardiac arrest occurred in two horses during routine surgical anaesthesia."1.27Cardiac arrest during anaesthesia in two horses. ( Kellagher, RE; Watney, GC, 1986)
" A dosage of 30 to 40 mg of ketamine HCl/kg of body weight and 1."1.26Intravenously administered ketamine HCl and diazepam for anesthesia of raptors. ( Duke, GE; Redig, PT, 1976)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19903 (16.67)18.7374
1990's2 (11.11)18.2507
2000's3 (16.67)29.6817
2010's8 (44.44)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
King, C1
Lewinsohn, A1
Keeliher, C1
McLachlan, S1
Sherrin, J1
Khan-Cheema, H1
Sherren, P1
Ornowska, M1
Wormsbecker, A1
Andolfatto, G1
Leung, TS1
Khan, I1
Medvedev, G1
Kuklin, V1
Akhatov, N1
Kondratiev, T1
Konkayev, A1
Baigenzhin, A1
Konkayeva, M1
Karibekov, T1
Barlow, N1
Tveita, T1
Dahl, V1
Xu, DJ1
Wang, B1
Zhao, X1
Zheng, Y1
Du, JL1
Wang, YW1
Koffman, L1
Yan Yiu, H1
Farrokh, S1
Lewin, J1
Geocadin, R1
Ziai, W1
Bendel, S1
Springe, D1
Pereira, A1
Grandgirard, D1
Leib, SL1
Putzu, A1
Schlickeiser, J1
Jakob, SM1
Takala, J1
Haenggi, M1
Grunwell, JR1
Travers, C1
McCracken, CE1
Scherrer, PD1
Stormorken, AG1
Chumpitazi, CE1
Roback, MG1
Stockwell, JA1
Kamat, PP1
Burmon, C1
Adamakos, F1
Filardo, M1
Motov, S1
Williams, GD1
Maan, H1
Ramamoorthy, C1
Kamra, K1
Bratton, SL1
Bair, E1
Kuan, CC1
Hammer, GB1
Feinstein, JA1
Murphy, TW1
Smith, JH1
Ranger, MR1
Haynes, SR1
Ferrera, R1
Michel, P1
Reid, KH1
Paskitti, M1
Guo, SZ1
Schmelzer, T1
Iyer, V1
Schöning, B1
Sommer, K1
Koch, H1
Busund, R1
Balteskard, L1
Rønning, G1
Høgåsen, K1
Revhaug, A1
Jasani, MS1
Salzman, SK1
Tice, LL1
Ginn, A1
Nadkarni, VM1
Ben-Shlomo, I1
Rosenbaum, A1
Hadash, O1
Katz, Y1
Redig, PT1
Duke, GE1
Kellagher, RE1
Watney, GC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Triple-blind Placebo Controlled Trial of Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival and Neurological Outcome[NCT04009759]Phase 1240 participants (Anticipated)Interventional2021-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for ketamine and Asystole

ArticleYear
The use of ketamine as a neuroprotective agent following cardiac arrest: A scoping review of current literature.
    CNS neuroscience & therapeutics, 2023, Volume: 29, Issue:1

    Topics: Brain Injuries, Traumatic; Heart Arrest; Humans; Ketamine; Neuroprotection; Neuroprotective Agents

2023

Trials

1 trial available for ketamine and Asystole

ArticleYear
[Heart arrest during dextran infusion despite hapten blockade].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1984, Volume: 19, Issue:1

    Topics: Aged; Anaphylaxis; Bronchial Spasm; Dextrans; Epinephrine; Heart Arrest; Humans; Infusions, Parenter

1984

Other Studies

16 other studies available for ketamine and Asystole

ArticleYear
Cardiovascular complications of prehospital emergency anaesthesia in patients with return of spontaneous circulation following medical cardiac arrest: a retrospective comparison of ketamine-based and midazolam-based induction protocols.
    Emergency medicine journal : EMJ, 2022, Volume: 39, Issue:9

    Topics: Aged; Anesthesia; Emergency Medical Services; Heart Arrest; Humans; Hypotension; Ketamine; Midazolam

2022
The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest.
    BMC anesthesiology, 2019, 11-20, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Animals; Asphyxia; Blood Gas Analysis; Brain Injuries; Cardiopulmonary Resuscita

2019
General anesthetics protects against cardiac arrest-induced brain injury by inhibiting calcium wave propagation in zebrafish.
    Molecular brain, 2017, 09-04, Volume: 10, Issue:1

    Topics: Anesthetics, General; Animals; Apoptosis; Brain; Brain Injuries; Calcium Signaling; Heart Arrest; Ke

2017
Ketamine infusion for refractory status epilepticus: A case report of cardiac arrest.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2018, Volume: 47

    Topics: Aged; Anticonvulsants; Female; Heart Arrest; Humans; Ketamine; Status Epilepticus

2018
Do different anesthesia regimes affect hippocampal apoptosis and neurologic deficits in a rodent cardiac arrest model?
    BMC anesthesiology, 2015, Jan-15, Volume: 15

    Topics: Anesthetics; Animals; Apoptosis; Fentanyl; Heart Arrest; Hippocampus; Ketamine; Male; Medetomidine;

2015
Procedural Sedation Outside of the Operating Room Using Ketamine in 22,645 Children: A Report From the Pediatric Sedation Research Consortium.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2016, Volume: 17, Issue:12

    Topics: Adolescent; Child; Child, Preschool; Emergency Service, Hospital; Female; Heart Arrest; Hospitals, G

2016
Acute pulmonary edema associated with ketamine-induced hypertension during procedural sedation in the ED.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:3

    Topics: Acute Disease; Anesthetics, Dissociative; Anti-Bacterial Agents; Arthralgia; Arthrocentesis; Cardiop

2017
Perioperative complications in children with pulmonary hypertension undergoing general anesthesia with ketamine.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:1

    Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Blood Pressure; Cardiac Surgical Procedu

2010
General anesthesia for children with severe heart failure.
    Pediatric cardiology, 2011, Volume: 32, Issue:2

    Topics: Adolescent; Anesthesia, General; Anesthetics, Dissociative; Child; Child, Preschool; Female; Health

2011
Protection of the ischemic heart during reperfusion: role of the low flow to avoid calcium overload into the myocardium in a pig model.
    Transplantation proceedings, 2002, Volume: 34, Issue:8

    Topics: Animals; Calcium; Disease Models, Animal; Excitatory Amino Acid Antagonists; Heart Arrest; Ketamine;

2002
Experience with ketamine and sodium pentobarbital as anesthetics in a rat model of cardiac arrest and resuscitation.
    Resuscitation, 2003, Volume: 57, Issue:2

    Topics: Anesthetics, Dissociative; Animals; Brain; Cardiopulmonary Resuscitation; Disease Models, Animal; He

2003
Fatal myocardial depression and circulatory collapse associated with complement activation induced by plasma infusion in severe porcine sepsis.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:1

    Topics: Albumins; Anesthesia, Inhalation; Animals; Blood Pressure; Blood Transfusion; Calcium; Cardiac Outpu

1995
Anesthetic regimen effects on a pediatric porcine model of asphyxial arrest.
    Resuscitation, 1997, Volume: 35, Issue:1

    Topics: Adjuvants, Anesthesia; Anesthesia, General; Anesthetics, Combined; Anesthetics, Dissociative; Anesth

1997
Intravenous midazolam significantly enhances the lethal effect of thiopental but not that of ketamine in mice.
    Pharmacological research, 2001, Volume: 44, Issue:6

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug

2001
Intravenously administered ketamine HCl and diazepam for anesthesia of raptors.
    Journal of the American Veterinary Medical Association, 1976, Nov-01, Volume: 169, Issue:9

    Topics: Anesthesia, General; Animals; Bird Diseases; Birds; Diazepam; Heart Arrest; Injections, Intravenous;

1976
Cardiac arrest during anaesthesia in two horses.
    The Veterinary record, 1986, Oct-04, Volume: 119, Issue:14

    Topics: Anesthesia; Animals; Electrocardiography; Heart Arrest; Heart Block; Heart Rate; Horse Diseases; Hor

1986