ketamine has been researched along with MODS in 4 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The use of etomidate as the sedative agent in this context has been challenged because it might cause a reversible adrenal insufficiency, potentially associated with increased in-hospital morbidity." | 5.14 | Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. ( Adnet, F; Albizzati, S; Anguel, N; Beltramini, A; Bertrand, L; Bollaert, PE; Brun-Buisson, C; Chollet-Xemard, C; Combes, X; Dhaouadi, M; Gamand, P; Jabre, P; Lapostolle, F; Lebail, G; Lefrant, JY; Maxime, V; Megarbane, B; Perdrizet, D; Ricard, JD; Ricard-Hibon, A; Vicaut, E; Vivien, B, 2009) |
| "To assess the effect of continuous hemodiafiltration (CHDF) on ketamine and midazolam kinetics in multiple organ dysfunction syndrome (MODS)." | 5.09 | Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome. ( Ishihara, H; Matsuki, A; Okawa, H; Sakai, I; Tsubo, T, 2001) |
| " In this study, we examined whether (R)-ketamine could prevent against lethal sepsis-induced systemic inflammation and inflammatory organ injury." | 4.02 | (R)-Ketamine ameliorates lethal inflammatory responses and multi-organ injury in mice induced by cecum ligation and puncture. ( Hashimoto, K; Hashimoto, Y; Ma, L; Qu, Y; Shan, J; Wan, X; Zhang, J, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Ma, L | 1 |
| Hashimoto, Y | 1 |
| Wan, X | 1 |
| Shan, J | 1 |
| Qu, Y | 1 |
| Hashimoto, K | 1 |
| Jabre, P | 1 |
| Combes, X | 1 |
| Lapostolle, F | 1 |
| Dhaouadi, M | 1 |
| Ricard-Hibon, A | 1 |
| Vivien, B | 1 |
| Bertrand, L | 1 |
| Beltramini, A | 1 |
| Gamand, P | 1 |
| Albizzati, S | 1 |
| Perdrizet, D | 1 |
| Lebail, G | 1 |
| Chollet-Xemard, C | 1 |
| Maxime, V | 1 |
| Brun-Buisson, C | 1 |
| Lefrant, JY | 1 |
| Bollaert, PE | 1 |
| Megarbane, B | 1 |
| Ricard, JD | 1 |
| Anguel, N | 1 |
| Vicaut, E | 1 |
| Adnet, F | 1 |
| Suliburk, J | 1 |
| Helmer, K | 1 |
| Moore, F | 1 |
| Mercer, D | 1 |
| Tsubo, T | 1 |
| Sakai, I | 1 |
| Okawa, H | 1 |
| Ishihara, H | 1 |
| Matsuki, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Etomidate Versus Propofol As An Anesthesia Induction Agent For Patients Undergoing CABG Surgery, Assessing Hemodynamic Stability. A Single Blinded, Randomized Controlled Trial.[NCT06068764] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-12-05 | Recruiting | ||
| Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity[NCT00440102] | Phase 4 | 655 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| The Prevention of Post Operative Cognitive Dysfunction by Ketamine: a Prospective Multicenter Randomized Blinded Placebo-controlled Trial in Elderly Patients Undergoing Elective Orthopaedic Surgery[NCT02892916] | Phase 3 | 307 participants (Actual) | Interventional | 2017-03-20 | Completed | ||
| Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketamine and MODS
| Article | Year |
|---|---|
The gut in systemic inflammatory response syndrome and sepsis. Enzyme systems fighting multiple organ failure.
Topics: Anesthetics, Dissociative; Animals; Gastrointestinal Tract; Heme Oxygenase (Decyclizing); Infections | 2008 |
2 trials available for ketamine and MODS
| Article | Year |
|---|---|
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial.
Topics: Adrenal Insufficiency; Aged; Anesthetics, Intravenous; Critical Illness; Etomidate; Female; France; | 2009 |
Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome.
Topics: Analgesics; Anti-Anxiety Agents; Female; Glasgow Coma Scale; Hemodiafiltration; Humans; Ketamine; Ma | 2001 |
1 other study available for ketamine and MODS
| Article | Year |
|---|---|
(R)-Ketamine ameliorates lethal inflammatory responses and multi-organ injury in mice induced by cecum ligation and puncture.
Topics: Animals; Biomarkers; Cecum; Cytokines; Disease Models, Animal; Inflammation; Inflammation Mediators; | 2021 |