ketamine has been researched along with Aggression in 18 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine is a dissociative anesthetic that has been shown to have antidepressant effects in humans and has been proposed as a potential treatment for mood disorders such as posttraumatic stress disorder and aggression." | 8.31 | A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice. ( Aaflaq, S; Bartsch, CJ; Jacobs, JT; Li, Z; Nordman, JC; Qasem, E; Skinner, S; Smith, M; Summa, F; Thompson, R, 2023) |
| "The dose-response effects of ketamine, an intravenous anesthetic with psychotomimetic properties which is a ketone derivative of phencyclidine, were evaluated in several experimental animal models of aggression." | 7.67 | Effects of ketamine on experimental animal models of aggression. ( Monteiro-de-Lima, TC; Morato, GS; Takahashi, RN, 1984) |
| "Ketamine is a dissociative anesthetic in human and veterinary clinic, as well as an abuse drug that acts on several neurotransmitter systems." | 5.72 | Ketamine acutely impairs memory consolidation and repeated exposure promotes stereotyped behavior without changing anxiety- and aggression-like parameters in adult zebrafish. ( Franscescon, F; Michelotti, P; Müller, TE; Pereira, ME; Rosemberg, DB, 2022) |
| "The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) has recently been suggested as an ideal antidepressant for treating animal models of depression." | 3.96 | Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions. ( Chou, D, 2020) |
| "After peri-adolescence isolation rearing (IS) and subchronic ketamine (KET) treatment, adult, selectively bred Wistar rats (named WISKET) mimic abnormal behaviors reminiscent of human schizophrenia, including reduced prepulse-inhibition of startle reflex, disturbances in cognition, locomotor activity and thermoregulation, decreased pain sensitivity and electrophysiological alterations." | 3.91 | Impaired GAD1 expression in schizophrenia-related WISKET rat model with sex-dependent aggressive behavior and motivational deficit. ( Benedek, G; Büki, A; Ducza, E; Horvath, G; Kekesi, G, 2019) |
| "The current experiments explore aggression and medial prefrontal cortex (mPFC) glutamate as consequences of withdrawal from intermittent access to EtOH and changes in aggression and mPFC glutamate caused by NMDAR antagonists memantine and ketamine." | 3.81 | Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice. ( DeBold, JF; Holly, EN; Hwa, LS; Miczek, KA; Nathanson, AJ; Newman, EL; Shimamoto, A; Tayeh, JK; Wilens, AR, 2015) |
| "The dose-response effects of ketamine, an intravenous anesthetic with psychotomimetic properties which is a ketone derivative of phencyclidine, were evaluated in several experimental animal models of aggression." | 3.67 | Effects of ketamine on experimental animal models of aggression. ( Monteiro-de-Lima, TC; Morato, GS; Takahashi, RN, 1984) |
| "Ketamine is a non-competitive glutamatergic antagonist that induces analgesia and anesthesia." | 1.48 | Ketamine modulates aggressive behavior in adult zebrafish. ( Michelotti, P; Pereira, ME; Quadros, VA; Rosemberg, DB, 2018) |
| "Ketamine was administered for agitation on 32 visits involving 27 patients." | 1.42 | Ketamine use for acute agitation in the emergency department. ( Campillo, A; Castillo, EM; Davie, T; Hopper, AB; Vilke, GM; Wilson, MP, 2015) |
| " Eight patients developed adverse reactions, 3 of which required further evaluation in the emergency department." | 1.37 | Safety of deep sedation in an urban oral and maxillofacial surgery training program. ( Braidy, HF; Singh, P; Ziccardi, VB, 2011) |
| " We conclude that 5 to 10 mg/kg oral ketamine in water which has a bioavailability of approximately 20% is a useful agent for the preinduction of patients who aggressively refuse medical treatment." | 1.28 | [Oral ketamine as preferred preanesthetic medication of uncooperative patients]. ( Jacobs, FE; Neckel, W; Tolksdorf, W, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 7 (38.89) | 24.3611 |
| 2020's | 6 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Michelotti, P | 2 |
| Franscescon, F | 1 |
| Müller, TE | 1 |
| Rosemberg, DB | 2 |
| Pereira, ME | 2 |
| Nordman, JC | 2 |
| Bartsch, CJ | 2 |
| Li, Z | 2 |
| Parker, LA | 1 |
| Krebs, K | 1 |
| Pan, PL | 1 |
| Varner, KM | 1 |
| Hoddinott, KL | 1 |
| Aaflaq, S | 1 |
| Jacobs, JT | 1 |
| Smith, M | 1 |
| Summa, F | 1 |
| Skinner, S | 1 |
| Qasem, E | 1 |
| Thompson, R | 1 |
| Chou, D | 2 |
| Kim, HK | 1 |
| Leonard, JB | 1 |
| Corwell, BN | 1 |
| Connors, NJ | 1 |
| Smith-Martinez, LA | 1 |
| Chatham, LN | 1 |
| Muthukanagaraj, P | 1 |
| Büki, A | 1 |
| Horvath, G | 1 |
| Benedek, G | 1 |
| Ducza, E | 1 |
| Kekesi, G | 1 |
| Quadros, VA | 1 |
| Ye, L | 1 |
| Ko, CY | 1 |
| Huang, Y | 1 |
| Zheng, C | 1 |
| Zheng, Y | 1 |
| Hopper, AB | 1 |
| Vilke, GM | 1 |
| Castillo, EM | 1 |
| Campillo, A | 1 |
| Davie, T | 1 |
| Wilson, MP | 1 |
| Hwa, LS | 1 |
| Nathanson, AJ | 1 |
| Shimamoto, A | 1 |
| Tayeh, JK | 1 |
| Wilens, AR | 1 |
| Holly, EN | 1 |
| Newman, EL | 1 |
| DeBold, JF | 1 |
| Miczek, KA | 1 |
| Braidy, HF | 1 |
| Singh, P | 1 |
| Ziccardi, VB | 1 |
| Chan, WP | 1 |
| Chilvers, CR | 1 |
| Takahashi, RN | 1 |
| Morato, GS | 1 |
| Monteiro-de-Lima, TC | 1 |
| Bachenberg, KL | 1 |
| Roberts, JR | 1 |
| Geeting, GK | 1 |
| Neckel, W | 1 |
| Jacobs, FE | 1 |
| Tolksdorf, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn (stopped due to Trial never received funding.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketamine and Aggression
| Article | Year |
|---|---|
Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Benzodiazepines; Delirium; Emergency Service, Hospi | 2021 |
17 other studies available for ketamine and Aggression
| Article | Year |
|---|---|
Ketamine acutely impairs memory consolidation and repeated exposure promotes stereotyped behavior without changing anxiety- and aggression-like parameters in adult zebrafish.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Hydrocortisone; Ketamine; Memory Consolidation; Ster | 2022 |
Opposing effects of NMDA receptor antagonists on early life stress-induced aggression in mice.
Topics: Adverse Childhood Experiences; Aggression; Animals; Dizocilpine Maleate; Humans; Ketamine; Memantine | 2022 |
Treatment and outcome following substantial ketamine overdose in a dog.
Topics: Aggression; Animals; Dog Diseases; Dogs; Drug Overdose; Iatrogenic Disease; Ketamine; Male; Treatmen | 2023 |
A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice.
Topics: Adverse Childhood Experiences; Aggression; Animals; Anxiety; Depression; Fear; Humans; Ketamine; Mic | 2023 |
Brain-derived neurotrophic factor in the ventrolateral periaqueductal gray contributes to (2R,6R)-hydroxynorketamine-mediated actions.
Topics: Aggression; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Female; K | 2020 |
Intramuscular Ketamine Protocol as an Alternative to Physical Restraints for Electroconvulsive Therapy Administration in a Psychotic Patient: A Case Report.
Topics: Aged; Aggression; Anesthesia; Anesthetics, Dissociative; Electroconvulsive Therapy; Female; Humans; | 2019 |
Impaired GAD1 expression in schizophrenia-related WISKET rat model with sex-dependent aggressive behavior and motivational deficit.
Topics: Aggression; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Glutamate De | 2019 |
Ketamine modulates aggressive behavior in adult zebrafish.
Topics: Age Factors; Aggression; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonist | 2018 |
Ketamine metabolite (2R,6R)-hydroxynorketamine enhances aggression via periaqueductal gray glutamatergic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aggression; Animals; Behavior, Animal; Dose-Response Relations | 2019 |
Ketamine use for acute agitation in the emergency department.
Topics: Adult; Aged; Aggression; Alcoholic Intoxication; Anesthetics, Dissociative; Antipsychotic Agents; Be | 2015 |
Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Topics: Aggression; Animals; Behavior, Animal; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Ke | 2015 |
Safety of deep sedation in an urban oral and maxillofacial surgery training program.
Topics: Adjuvants, Anesthesia; Adult; Age Factors; Aggression; Akathisia, Drug-Induced; Ambulatory Surgical | 2011 |
Induction of anaesthesia in the home.
Topics: Adult; Aggression; Anesthesia; Anesthetics, Dissociative; Home Care Services, Hospital-Based; Humans | 2002 |
Effects of ketamine on experimental animal models of aggression.
Topics: Aggression; Animals; Apomorphine; Dose-Response Relationship, Drug; Humans; Ketamine; Male; Mice; Mi | 1984 |
Oral ketamine for the management of combative autistic adult.
Topics: Administration, Oral; Adult; Aggression; Autistic Disorder; Excitatory Amino Acid Antagonists; Human | 1998 |
Intramuscular ketamine for the rapid tranquilization of the uncontrollable, violent, and dangerous adult patient.
Topics: Adult; Aggression; Anesthetics, Dissociative; Emergency Service, Hospital; HIV Seropositivity; Human | 2001 |
[Oral ketamine as preferred preanesthetic medication of uncooperative patients].
Topics: Administration, Oral; Adult; Aggression; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Int | 1992 |