Page last updated: 2024-09-27

Excessive Periodic Sleep-Related Leg Movements

Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)

Synonyms(8)

Synonym
Nocturnal Myoclonus Syndrome
Periodic Leg Movements, Excessive, Sleep-Related
Excessive Periodic Sleep-Related Leg Movements
Periodic Limb Movement Disorder
Sleep Myoclonus Syndrome
Periodic Movement Disorder, Sleep
Sleep-Related Periodic Leg Movements, Excessive
Sleep Disorder, Periodic Movements

Research Excerpts

Treatment

ExcerptReference
"Antidepressant-induced periodic limb movement disorder (PLMD) may limit the tolerability of some antidepressant medications and interfere with treatment response."( Berman, S; Fasiczka, A; Nofzinger, EA; Thase, ME, 2000)

Research

Studies (150)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's80 (53.33)18.1394
2010's52 (34.67)28.8240
2020's18 (12.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
carbamates0low10
bupropion0low20
melatonin0medium52
urea0low10
homovanillic acid0low20
hydroxyindoleacetic acid0low10
acetazolamide0low10
amitriptyline0medium11
baclofen0low10
benserazide0low10
caffeine0low20
carbamazepine0low30
clebopride0low10
clomipramine0low10
clonazepam0low60
valproic acid0medium11
fentanyl0low10
ketamine0low10
lorazepam0low10
methylphenidate0low30
mianserin0medium11
mirtazapine0medium21
modafinil0medium11
apnea0medium41
nifedipine0low10
oxidopamine0low10
oxybutynin0medium21
piracetam0low10
pirenzepine0low10
ropinirole0medium41
temazepam0low10
zopiclone0low20
apomorphine0medium21
levodopa0medium204
thiophenes0medium31
thiazoles0low30
ferrous sulfate0low10
glucaric acid0low10
methyldopa0low10
paroxetine0low10
pergolide0medium61
fomesafen0low10
cabergoline0medium31
atomoxetine hydrochloride0low10
n 0437, (-)-isomer0medium31
6-sulfatoxymelatonin0medium11
fluorodeoxyglucose f180low10
sertraline0medium31
nicotine0low10
fibrinogen0low10
carbidopa, levodopa drug combination0low20
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide0medium11
pramipexole0medium124
tacrolimus0low10
cocaine0low10
levetiracetam0low10
naloxone0low10
casein kinase ii0low10
ergoline0medium31
acebutolol0low10
ent-dextilidine0low10
beta-endorphin0low10
sodium oxybate0low10
natriuretic peptide, brain0low10
ferric oxide, saccharated0low10
deoxyguanosine0low10
sapropterin0low10
olanzapine0low20
8-hydroxy-2'-deoxyguanosine0low10
eye0low10
ferric carboxymaltose0low10
carbidopa0medium42

Protein Targets (795)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
D(2) dopamine receptor021730
D(4) dopamine receptor012316
D(3) dopamine receptor022428
D(2) dopamine receptor019423
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase6006
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
thioredoxin reductase160016
GALC protein2002
GLI family zinc finger 3160016
nuclear receptor subfamily 1, group I, member 3140014
cytochrome P450 family 3 subfamily A polypeptide 4160016
glucocorticoid receptor [Homo sapiens]130013
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha140014
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A140014
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 2290029
Bloom syndrome protein isoform 1110011
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 1130013
geminin230023
peripheral myelin protein 22100010
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 14004
Gamma-aminobutyric acid receptor subunit pi105015
ATP-binding cassette sub-family C member 3023023
Multidrug resistance-associated protein 4023023
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Carbonic anhydrase 120216
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Bile salt export pump030030
Glycogen phosphorylase, muscle form0202
Renin0303
Carbonic anhydrase 10319
Carbonic anhydrase 20318
Carbonic anhydrase 20202
Cytochrome P450 1A20404
Carbonic anhydrase 30216
Cathepsin B0101
Cytochrome P450 3A40606
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C014014
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2D60808
Cytochrome P450 2A60415
Cytochrome P450 2C9 0505
5-hydroxytryptamine receptor 2A016016
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-1105015
Translocator protein0202
Gamma-aminobutyric acid receptor subunit delta105015
Gamma-aminobutyric acid receptor subunit gamma-2105217
Gamma-aminobutyric acid receptor subunit alpha-5105015
Gamma-aminobutyric acid receptor subunit alpha-3105015
Cannabinoid receptor 10101
Arachidonate 5-lipoxygenase-activating protein0101
Cytochrome P450 2B60114
Carbonic anhydrase 40215
Carbonic anhydrase 60215
Gamma-aminobutyric acid receptor subunit gamma-1105015
Gamma-aminobutyric acid receptor subunit alpha-2105015
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10406
Serum paraoxonase/arylesterase 10101
Dipeptidyl peptidase 40001
Gamma-aminobutyric acid receptor subunit alpha-4105015
Gamma-aminobutyric acid receptor subunit gamma-3105015
Endochitinase0101
Gamma-aminobutyric acid receptor subunit alpha-6105015
Adenosine receptor A2a0407
5-hydroxytryptamine receptor 2B013013
Sodium-dependent serotonin transporter010112
Delta-type opioid receptor0618
Cytochrome P450 2C190505
Delta-type opioid receptor0628
Mu-type opioid receptor08311
Carbonic anhydrase 5A, mitochondrial0216
Carbonic anhydrase0102
Kappa-type opioid receptor0516
Carbonic anhydrase 70215
Carbonic anhydrase0101
D(1A) dopamine receptor7108
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0102
Gamma-aminobutyric acid receptor subunit alpha-1105217
Gamma-aminobutyric acid receptor subunit beta-3105015
Gamma-aminobutyric acid receptor subunit beta-2105217
Cholinesterase0202
Carbonic anhydrase 0101
Mu-type opioid receptor0617
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0405
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70326
Carbonic anhydrase 90216
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0102
Carbonic anhydrase 30101
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0101
Sigma intracellular receptor 20202
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10718
Renin0101
Carbonic anhydrase 0102
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
GABA theta subunit105015
Canalicular multispecific organic anion transporter 1023023
Carbonic anhydrase 40202
Carbonic anhydrase 150103
Acidic mammalian chitinase0101
Carbonic anhydrase 130204
Carbonic anhydrase 70101
Gamma-aminobutyric acid receptor subunit epsilon105015
Carbonic anhydrase 0101
Carbonic anhydrase 140216
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Carbonic anhydrase 5B, mitochondrial0216
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
USP1 protein, partial9009
NFKB1 protein, partial6006
GLS protein180018
cytochrome P450 2D6140014
cytochrome P450 2D6 isoform 19009
D(1A) dopamine receptor140014
chromobox protein homolog 1200020
atrial natriuretic peptide receptor 2 precursor5005
serine/threonine-protein kinase mTOR isoform 18008
muscarinic acetylcholine receptor M19009
Solute carrier family 22 member 1 0506
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 4014014
Albumin0022
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B1013013
Muscarinic acetylcholine receptor M2016119
Muscarinic acetylcholine receptor M4016017
Muscarinic acetylcholine receptor M10707
Muscarinic acetylcholine receptor M30606
Muscarinic acetylcholine receptor M40606
Muscarinic acetylcholine receptor M50606
Muscarinic acetylcholine receptor M5016017
Alpha-2A adrenergic receptor015015
Muscarinic acetylcholine receptor M20606
Muscarinic acetylcholine receptor M1016221
Angiotensin-converting enzyme0707
Alpha-2B adrenergic receptor014014
Alpha-2C adrenergic receptor015015
5-hydroxytryptamine receptor 1A012012
Muscarinic acetylcholine receptor M3015016
D(1A) dopamine receptor013520
D(1B) dopamine receptor0416
UDP-glucuronosyltransferase 1A40104
Sodium-dependent noradrenaline transporter 021223
Histamine H2 receptor0729
Alpha-1D adrenergic receptor010010
5-hydroxytryptamine receptor 2A014317
5-hydroxytryptamine receptor 2C015116
5-hydroxytryptamine receptor 1B010010
5-hydroxytryptamine receptor 1D0808
5-hydroxytryptamine receptor 1F0808
5-hydroxytryptamine receptor 60606
Histamine H1 receptor0303
Sodium-dependent serotonin transporter019221
5-hydroxytryptamine receptor 7 0808
5-hydroxytryptamine receptor 5A0606
5-hydroxytryptamine receptor 5B0606
Histamine H1 receptor010212
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0405
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0808
5-hydroxytryptamine receptor 2B015116
Alpha-1A adrenergic receptor012113
Histamine H2 receptor83013
5-hydroxytryptamine receptor 6011012
5-hydroxytryptamine receptor 70303
Voltage-dependent N-type calcium channel subunit alpha-1B0202
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Sodium-dependent dopamine transporter 019221
Potassium voltage-gated channel subfamily H member 2015015
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0405
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0404
5-hydroxytryptamine receptor 4 0606
Nuclear receptor subfamily 3 group C member 3 0707
Sodium channel protein type 2 subunit alpha0202
Ataxin-2110011
Sigma non-opioid intracellular receptor 1018018
5-hydroxytryptamine receptor 3B0808
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0303
Sodium channel protein type 10 subunit alpha0202
ATAD5 protein, partial130013
TDP1 protein200020
Microtubule-associated protein tau6006
lamin isoform A-delta10180018
neuropeptide S receptor isoform A3003
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, 2-oxoglutarate Oxygenase6006
Luciferase7007
acetylcholinesterase7007
phosphopantetheinyl transferase110011
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma100010
AR protein200020
aldehyde dehydrogenase 1 family, member A1100010
estrogen receptor 2 (ER beta)6006
progesterone receptor8008
regulator of G-protein signaling 4150015
farnesoid X nuclear receptor6006
estrogen nuclear receptor alpha230023
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma8008
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a110011
thyroid stimulating hormone receptor8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)100010
Histone H2A.x5005
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C19 precursor4004
cytochrome P450 2C9 precursor6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
vitamin D3 receptor isoform VDRA9009
potassium voltage-gated channel subfamily H member 2 isoform d100010
thyroid hormone receptor beta isoform 2140014
mitogen-activated protein kinase 18008
nuclear receptor ROR-gamma isoform 16006
cytochrome P450 3A4 isoform 1100010
lethal factor (plasmid)5005
Voltage-dependent calcium channel gamma-2 subunit5005
Cellular tumor antigen p53150015
Integrin beta-32002
Integrin alpha-IIb2002
5-hydroxytryptamine receptor 1A08412
Tryptophan 5-hydroxylase 10202
Alpha-1B adrenergic receptor09110
D0909
D(3) dopamine receptor0819
Alpha-2B adrenergic receptor09110
Glutamate receptor 26006
D(2) dopamine receptor0505
Alpha-2C adrenergic receptor09110
Alpha-2A adrenergic receptor09110
Alpha-1D adrenergic receptor0718
D(1B) dopamine receptor0303
D(4) dopamine receptor0415
Spike glycoprotein130114
E3 ubiquitin-protein ligase Mdm20101
D0101
D0505
ATPase family AAA domain-containing protein 56006
ATP-dependent phosphofructokinase160016
glp-1 receptor, partial3003
IDH15005
67.9K protein5005
activating transcription factor 63003
histone acetyltransferase KAT2A isoform 17007
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
EWS/FLI fusion protein7007
M-phase phosphoprotein 89009
Zinc finger protein mex-50011
POsterior Segregation0011
Genome polyprotein0101
Replicase polyprotein 1ab0213
Hexokinase-20101
Acetylcholine receptor subunit alpha0314
Acetylcholine receptor subunit gamma0314
Integrin alpha-50101
Acetylcholine receptor subunit beta0314
UDP-glucuronosyltransferase 2B70205
Neuronal acetylcholine receptor subunit beta-20315
UDP-glucuronosyltransferase 1-60102
UDP-glucuronosyltransferase 1A1 0101
Sodium-dependent dopamine transporter011011
Neuronal acetylcholine receptor subunit beta-40315
Neuronal acetylcholine receptor subunit alpha-30314
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70325
Neuronal acetylcholine receptor subunit alpha-40315
Acetylcholine receptor subunit delta0314
pregnane X nuclear receptor130013
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor3003
DNA polymerase beta2002
DNA polymerase kappa isoform 15005
Potassium channel subfamily K member 20022
Cholinesterase0202
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0112
Adenosine receptor A30303
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0303
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Adenosine receptor A30101
Adenosine receptor A2a0315
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10417
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0202
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0113
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Guanine deaminase0101
thyroid stimulating hormone receptor8008
nuclear factor erythroid 2-related factor 2 isoform 21001
Vpr1001
Bile salt export pump0404
Major prion protein0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2J20404
Frizzled-80011
P2X purinoceptor 40202
Chain A, Protein kinase CK2, alpha Subunit0101
Chain A, PROTEIN KINASE CK2, alpha SUBUNIT0101
Chain A, Protein Kinase Ck2, Alpha Subunit0101
Chain A, Ferritin light chain3003
endonuclease IV3003
dopamine D1 receptor4004
Thrombopoietin3003
Parkin2002
NPC intracellular cholesterol transporter 1 precursor3003
peripheral myelin protein 22 isoform 15005
ras-related protein Rab-9A5005
DNA polymerase iota isoform a (long)5005
Serine/threonine-protein kinase Sgk10101
Ribosyldihydronicotinamide dehydrogenase [quinone]0314
Casein kinase II subunit alpha 0101
Casein kinase II subunit alpha'0202
Cyclin-A20101
Cyclin-dependent kinase 20101
Casein kinase II subunit beta0202
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0202
Cyclin-A10101
Dual specificity mitogen-activated protein kinase kinase 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Ribosomal protein S6 kinase alpha-10101
Casein kinase II subunit alpha 30202
Single-stranded DNA cytosine deaminase1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Fumarate hydratase7007
PPM1D protein2002
caspase 7, apoptosis-related cysteine protease3003
polyprotein7007
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-33003
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Interferon beta6006
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Trypanothione reductase0202
Trypanothione reductase0101
Proteasome subunit alpha type-60011
Inositol monophosphatase 16006
Envelope glycoprotein0033
Angiotensin-converting enzyme 2 0011
2,3-bisphosphoglycerate-independent phosphoglycerate mutase2002
Gamma-aminobutyric acid receptor subunit pi0505
Gamma-aminobutyric acid receptor subunit delta0505
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Neuronal acetylcholine receptor subunit alpha-40326
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit beta-20326
Gamma-aminobutyric acid receptor subunit alpha-10516
Gamma-aminobutyric acid receptor subunit beta-10516
Gamma-aminobutyric acid receptor subunit gamma-20516
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30516
Translocator protein0101
Translocator protein0303
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50516
Gamma-aminobutyric acid receptor subunit alpha-30516
Gamma-aminobutyric acid receptor subunit alpha-20516
Gamma-aminobutyric acid receptor subunit beta-20516
Gamma-aminobutyric acid receptor subunit alpha-40516
Gamma-aminobutyric acid receptor subunit epsilon0505
Gamma-aminobutyric acid receptor subunit alpha-60516
Gamma-aminobutyric acid receptor subunit gamma-10505
Gamma-aminobutyric acid receptor subunit gamma-30505
Gamma-aminobutyric acid receptor subunit theta0505
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Amyloid-beta precursor protein0202
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Liver carboxylesterase 10102
Glutamate receptor ionotropic, NMDA 1 0304
Lysosomal Pro-X carboxypeptidase0101
Glutamate receptor ionotropic, NMDA 2A 0304
Glutamate receptor ionotropic, NMDA 2C0304
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10102
Sodium-dependent dopamine transporter0303
Glutamate receptor ionotropic, NMDA 2D0304
Glutamate receptor ionotropic, NMDA 3B0304
Leukotriene B4 receptor 20102
Glutamate receptor ionotropic, NMDA 3A0304
Transporter014116
Thymidine kinase, cytosolic0102
Deoxycytidine kinase0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
Nuclear receptor subfamily 1 group I member 20022
ATP-dependent translocase ABCB10405
Kappa-type opioid receptor0224
Mu-type opioid receptor0427
Delta-type opioid receptor0517
Kappa-type opioid receptor0427
Mu-type opioid receptor0203
Sigma non-opioid intracellular receptor 10303
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0023
bromodomain adjacent to zinc finger domain 2B3003
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
Histone deacetylase 30303
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40303
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 433003
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60303
Histone deacetylase 90303
Histone deacetylase 50303
ClpP2002
lysosomal alpha-glucosidase preproprotein3003
Solute carrier family 22 member 80001
Smad35005
hypothetical protein, conserved3003
alpha-galactosidase1001
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Uracil nucleotide/cysteinyl leukotriene receptor0101
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 34004
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
chaperonin-containing TCP-1 beta subunit homolog1001
flap endonuclease 15005
Synaptic vesicle glycoprotein 2A0202
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
15-lipoxygenase, partial2002
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA12002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
pyruvate kinase2002
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
Polyphenol oxidase 20001
Epidermal growth factor receptor0202
Plasma kallikrein0001
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0202
Polyunsaturated fatty acid lipoxygenase ALOX150404
Tyrosinase0101
Solute carrier family 15 member 10202
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase-like protein, putative0001
Monocarboxylate transporter 100001
phosphoglycerate kinase2002
Fatty acid-binding protein, liver0101
interleukin 82002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0202
Cytochrome P450 2C11 0101
Aromatase0101
Metabotropic glutamate receptor 10101
Acetylcholinesterase 0101
Nociceptin receptor0101
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear receptor ROR-gamma4004
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Carboxylic ester hydrolase 0101
Caspase 6, apoptosis-related cysteine peptidase0001
thioredoxin glutathione reductase2002
estrogen receptor beta isoform 10101
Cystathionine gamma-lyase0101
5-hydroxytryptamine receptor 3E0303
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
huntingtin isoform 21001
5-hydroxytryptamine receptor 3B0303
Endothelin receptor type B0101
5-hydroxytryptamine receptor 3A0202
Endothelin receptor type B0101
Endothelin-1 receptor0101
5-hydroxytryptamine receptor 1D0202
5-hydroxytryptamine receptor 70505
Alpha-1A adrenergic receptor0404
Type-2 angiotensin II receptor0303
5-hydroxytryptamine receptor 3A0505
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 3D0303
5-hydroxytryptamine receptor 3C0303
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
Transporter0202
G4004
HLA class I histocompatibility antigen, B alpha chain 4004
Inositol hexakisphosphate kinase 14004
cytochrome P450 2C9, partial4004
Histidine decarboxylase0011
Kappa-type opioid receptor0102
Beta-2 adrenergic receptor0102
UDP-glucuronosyltransferase 1A80001
Atrial natriuretic peptide receptor 10101
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Muscarinic acetylcholine receptor M40202
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10102
Transient receptor potential cation channel subfamily A member 10022
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20102
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
pregnane X receptor2002
nonstructural protein 12002
beta-2 adrenergic receptor1001
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
perilipin-50101
perilipin-10101
heat shock protein beta-11001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Glutathione reductase, mitochondrial0202
Phospholipase A2, membrane associated0001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Potassium voltage-gated channel subfamily A member 50101
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Thromboxane-A synthase 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Indoleamine 2,3-dioxygenase 10101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
C-C chemokine receptor type 20202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Myosin light chain kinase, smooth muscle0101
Potassium channel subfamily K member 2 0101
Indoleamine 2,3-dioxygenase 20101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
FAD-linked sulfhydryl oxidase ALR0001
Glucose-6-phosphate 1-dehydrogenase0101
Histamine H1 receptor0101
Alpha-1B adrenergic receptor0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Disintegrin and metalloproteinase domain-containing protein 172002
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Glyceraldehyde-3-phosphate dehydrogenase0101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
DNA repair protein RAD52 homolog0101
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Sodium-dependent noradrenaline transporter0101
Quinolone resistance protein NorA0101
Aldo-keto reductase family 1 member B10101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Rhodopsin kinase GRK10101
Sodium-dependent serotonin transporter0101
Beta-adrenergic receptor kinase 10001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Alpha-synuclein0101
Guanine nucleotide-binding protein G1001
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor DM10101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M20101
Beta-2 adrenergic receptor0101
Beta-3 adrenergic receptor0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 5A0101
Histamine H4 receptor0112
Nitric oxide synthase, brain0011
Transcriptional activator protein LuxR0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
Free fatty acid receptor 30011
Cytochrome P450 3A50101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Solute carrier organic anion transporter family member 1B10101
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]