ketamine has been researched along with Delirium of Mixed Origin in 67 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "None of the three study arms - haloperidol, ketamine, or both drugs combined - was significantly superior to placebo for prevention of postoperative brain dysfunction and delirium (P = 0." | 9.41 | Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. ( Brügger, J; Gysi, B; Hollinger, A; Huber, J; Rentsch, K; Riegger, H; Rüst, CA; Schmid, HR; Siegemund, M; Steiner, L; Surbeck, M; Toft, K; Tran, F, 2021) |
| "Low doses of ketamine are commonly used to decrease opiates tolerance, hyperalgesia and delirium in perioperative theatre but these properties have never been studied in intensive care unit (ICU) patients." | 9.27 | Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind control trial. ( Bazin, JE; Cayot, S; Chartier, C; Constantin, JM; Futier, E; Godet, T; Guerin, R; Jabaudon, M; Morand, D; Perbet, S; Pereira, B; Verdonk, F, 2018) |
| "There is limited but promising evidence that haloperidol and ketamine can be used to prevent delirium." | 9.27 | Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDe): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. ( Blum, A; Hollinger, A; Riegger, H; Seifert, B; Siegemund, M; Toft, K; Zehnder, T, 2018) |
| "A single subanaesthetic dose of ketamine did not decrease delirium in older adults after major surgery, and might cause harm by inducing negative experiences." | 9.24 | Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. ( Abdallah, AB; Arya, VK; Avidan, MS; Downey, RJ; Emmert, DA; Fritz, BA; Grocott, HP; Hudetz, JA; Inouye, SK; Jacobsohn, E; Lee, YH; Mashour, GA; Maybrier, HR; Muench, MR; Noh, GJ; Pagel, PS; Pryor, KO; Rogers, EM; Veselis, RA; Vlisides, PE; Waberski, W; Waszynski, CM; Yulico, H, 2017) |
| "After cardiac surgery using cardiopulmonary bypass, ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect." | 9.14 | Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. ( Byrne, AJ; Gandhi, SD; Hudetz, AG; Hudetz, JA; Iqbal, Z; Pagel, PS; Patterson, KM; Warltier, DC, 2009) |
| "5 micrograms/kg dexmedetomidine is effective in attenuating the cardiostimulatory and postanesthetic delirium effects of ketamine." | 9.08 | Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. ( Levänen, J; Mäkelä, ML; Scheinin, H, 1995) |
| "The effect of ketamine on postoperative delirium remains unclear but its administration may offer some protection towards POCD." | 8.98 | Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. ( Beck-Schimmer, B; Hovaguimian, F; Puhan, M; Tschopp, C, 2018) |
| "Ketamine induced delirium-like behavior in mice and increased tau amounts in serum of mice." | 8.31 | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking. ( Dong, Y; Liang, F; Ren, X; Song, A; Wu, X; Xie, Z; Yang, Y; Zhang, S; Zhang, Y, 2023) |
| "Over 28 months at two large community hospitals, all medical records were retrospectively searched for all patients age 18 years or greater with prehospital ketamine intramuscular (IM) administration for excited delirium and identified illicit and prescription substance co-ingestions." | 8.02 | Prehospital Ketamine Administration for Excited Delirium with Illicit Substance Co-Ingestion and Subsequent Intubation in the Emergency Department. ( Alter, SM; Clayton, LM; Hennekens, CH; Hughes, PG; Parks, DJ; Polley, SE; Shih, RD; Solano, JJ, 2021) |
| " SDDK was used in 210 ED encounters, while dissociative sedation ketamine for severe agitation/excited delirium was used in 37 ED encounters." | 7.96 | Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020) |
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 7.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| "This pilot study establishes groundwork for further studies to investigate if the ketamine dose can decrease the incidence of postoperative delirium in the initial 90 minutes after surgery without decreasing its analgesic effect." | 7.91 | Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. ( Gupta, DK; Muckler, VC; Plyler, SS; Rice, AN; Titch, JF, 2019) |
| "S-ketamine has neuroprotective properties as a dissociative anaesthetic." | 7.11 | Effects of subanaesthetic S-ketamine on postoperative delirium and cognitive function in elderly patients undergoing non-cardiac thoracic surgery: a protocol for a randomised, double-blinded, placebo-controlled and positive-controlled, non-inferiority tri ( Gu, Y; Liu, L; Tang, C; Wei, W; Yao, Y; Zhang, A; Zheng, X; Zhou, M, 2022) |
| "Opioid consumption, pain levels, hyperalgesia at the incision site, and delirium scores were assessed 48 h postoperatively." | 6.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
| "Ketamine has a role for agitation management in the prehospital setting; however, emergency personnel education and ketamine protocols should be utilized to aid in safe and effective pharmacotherapy and provide guidance on the management of adverse events." | 6.58 | Ketamine for the Acute Management of Excited Delirium and Agitation in the Prehospital Setting. ( Linder, LM; Ross, CA; Weant, KA, 2018) |
| "(R)-Ketamine (10 mg/kg) was administrated i." | 5.62 | (R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation. ( Hashimoto, K; Ma, L; Qu, Y; Shan, J; Wan, X; Zhang, J, 2021) |
| "Ketamine is a noncompetitive N-methyl-D-aspartic acid receptor antagonist, making it an effective dissociative agent." | 5.46 | A Novel Agent for Management of Agitated Delirium: A Case Series of Ketamine Utilization in the Pediatric Emergency Department. ( Kopec, KT; Kowalski, JM; Lavelle, J; Osterhoudt, K, 2017) |
| "Ketamine has a rapid, predictable onset within three to four minutes when given by intramuscular (IM) injection." | 5.43 | Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System. ( Glass, DM; Hutchcraft, MG; Scaggs, TR; Weir, WB, 2016) |
| "None of the three study arms - haloperidol, ketamine, or both drugs combined - was significantly superior to placebo for prevention of postoperative brain dysfunction and delirium (P = 0." | 5.41 | Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial. ( Brügger, J; Gysi, B; Hollinger, A; Huber, J; Rentsch, K; Riegger, H; Rüst, CA; Schmid, HR; Siegemund, M; Steiner, L; Surbeck, M; Toft, K; Tran, F, 2021) |
| "Low doses of ketamine are commonly used to decrease opiates tolerance, hyperalgesia and delirium in perioperative theatre but these properties have never been studied in intensive care unit (ICU) patients." | 5.27 | Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind control trial. ( Bazin, JE; Cayot, S; Chartier, C; Constantin, JM; Futier, E; Godet, T; Guerin, R; Jabaudon, M; Morand, D; Perbet, S; Pereira, B; Verdonk, F, 2018) |
| "There is limited but promising evidence that haloperidol and ketamine can be used to prevent delirium." | 5.27 | Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial (PRIDe): a phase IV multicenter, randomized, placebo-controlled, double-blind clinical trial of ketamine versus haloperidol for prevention of postoperative delirium. ( Blum, A; Hollinger, A; Riegger, H; Seifert, B; Siegemund, M; Toft, K; Zehnder, T, 2018) |
| "A single subanaesthetic dose of ketamine did not decrease delirium in older adults after major surgery, and might cause harm by inducing negative experiences." | 5.24 | Intraoperative ketamine for prevention of postoperative delirium or pain after major surgery in older adults: an international, multicentre, double-blind, randomised clinical trial. ( Abdallah, AB; Arya, VK; Avidan, MS; Downey, RJ; Emmert, DA; Fritz, BA; Grocott, HP; Hudetz, JA; Inouye, SK; Jacobsohn, E; Lee, YH; Mashour, GA; Maybrier, HR; Muench, MR; Noh, GJ; Pagel, PS; Pryor, KO; Rogers, EM; Veselis, RA; Vlisides, PE; Waberski, W; Waszynski, CM; Yulico, H, 2017) |
| "After cardiac surgery using cardiopulmonary bypass, ketamine attenuates postoperative delirium concomitant with an anti-inflammatory effect." | 5.14 | Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. ( Byrne, AJ; Gandhi, SD; Hudetz, AG; Hudetz, JA; Iqbal, Z; Pagel, PS; Patterson, KM; Warltier, DC, 2009) |
| "5 micrograms/kg dexmedetomidine is effective in attenuating the cardiostimulatory and postanesthetic delirium effects of ketamine." | 5.08 | Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. ( Levänen, J; Mäkelä, ML; Scheinin, H, 1995) |
| "The effect of ketamine on postoperative delirium remains unclear but its administration may offer some protection towards POCD." | 4.98 | Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. ( Beck-Schimmer, B; Hovaguimian, F; Puhan, M; Tschopp, C, 2018) |
| "Ketamine induced delirium-like behavior in mice and increased tau amounts in serum of mice." | 4.31 | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking. ( Dong, Y; Liang, F; Ren, X; Song, A; Wu, X; Xie, Z; Yang, Y; Zhang, S; Zhang, Y, 2023) |
| "Over 28 months at two large community hospitals, all medical records were retrospectively searched for all patients age 18 years or greater with prehospital ketamine intramuscular (IM) administration for excited delirium and identified illicit and prescription substance co-ingestions." | 4.02 | Prehospital Ketamine Administration for Excited Delirium with Illicit Substance Co-Ingestion and Subsequent Intubation in the Emergency Department. ( Alter, SM; Clayton, LM; Hennekens, CH; Hughes, PG; Parks, DJ; Polley, SE; Shih, RD; Solano, JJ, 2021) |
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 3.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| " SDDK was used in 210 ED encounters, while dissociative sedation ketamine for severe agitation/excited delirium was used in 37 ED encounters." | 3.96 | Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience. ( Campbell, MJ; Casserly, E; Fertel, BS; Lam, SW; Meldon, SW; Mo, H; Wells, EJ, 2020) |
| "This pilot study establishes groundwork for further studies to investigate if the ketamine dose can decrease the incidence of postoperative delirium in the initial 90 minutes after surgery without decreasing its analgesic effect." | 3.91 | Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients. ( Gupta, DK; Muckler, VC; Plyler, SS; Rice, AN; Titch, JF, 2019) |
| " The objective is to demonstrate that ketamine, given as a single intramuscular injection for violent and agitated patients, including those with suspected excited delirium syndrome (ExDS), is both safe and effective during the prehospital phase of care, and allows for the rapid sedation and control of this difficult patient population." | 3.80 | Prehospital use of i.m. ketamine for sedation of violent and agitated patients. ( Braghiroli, J; Chait, R; Scheppke, KA; Shalaby, M, 2014) |
| "The belief that ketamine, in the doses used for ED PPS, causes frequent emergence delirium is flawed." | 3.75 | What is the nature of the emergence phenomenon when using intravenous or intramuscular ketamine for paediatric procedural sedation? ( Bell, A; Cardwell, R; Cashion, G; Chand, D; Fincher, G; Treston, G, 2009) |
| "The ability of a number of drugs to abolish the emergence delirium and unpleasant dreams which follow anaesthesia induced with 2 mg/kg ketamine was studied." | 3.66 | Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions. ( Dundee, JW; Fee, JP; Johnston, HM; Lilburn, JK; Nair, SG, 1978) |
| "S-ketamine has neuroprotective properties as a dissociative anaesthetic." | 3.11 | Effects of subanaesthetic S-ketamine on postoperative delirium and cognitive function in elderly patients undergoing non-cardiac thoracic surgery: a protocol for a randomised, double-blinded, placebo-controlled and positive-controlled, non-inferiority tri ( Gu, Y; Liu, L; Tang, C; Wei, W; Yao, Y; Zhang, A; Zheng, X; Zhou, M, 2022) |
| "Opioid consumption, pain levels, hyperalgesia at the incision site, and delirium scores were assessed 48 h postoperatively." | 2.82 | The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial. ( Bornemann-Cimenti, H; Edler, A; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2016) |
| "Ketamine has been used as an anaesthetic drug for over 50 years and has an established safety record." | 2.79 | The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) study: protocol for an international multicentre randomised controlled trial. ( Arya, VK; Avidan, MS; Ben Abdallah, A; Chen, Y; Choi, S; Downey, RJ; Escallier, KE; Fritz, BA; Grocott, HP; Hudetz, JA; Inouye, SK; Jacobsohn, E; Kaiser, H; Mashour, GA; Maybrier, HR; Muench, MR; Noh, G; Pagel, PS; Pong, R; Pryor, K; Veselis, RA, 2014) |
| " Dosing recommendations however are often based on strategies used in patients with normal body habitus." | 2.66 | Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium. ( Barletta, JF; Erstad, BL, 2020) |
| "Ketamine has a role for agitation management in the prehospital setting; however, emergency personnel education and ketamine protocols should be utilized to aid in safe and effective pharmacotherapy and provide guidance on the management of adverse events." | 2.58 | Ketamine for the Acute Management of Excited Delirium and Agitation in the Prehospital Setting. ( Linder, LM; Ross, CA; Weant, KA, 2018) |
| "Ketamine may be a safe and feasible analgesic for medical and cardiac ICU patients who received mechanical ventilation support as an opioid-sparing agent without adverse hemodynamic effects." | 1.72 | Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study. ( Ahn, HY; Chung, CR; Jung, H; Ko, RE; Lee, J; Suh, GY; Yang, JH, 2022) |
| "(R)-Ketamine (10 mg/kg) was administrated i." | 1.62 | (R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation. ( Hashimoto, K; Ma, L; Qu, Y; Shan, J; Wan, X; Zhang, J, 2021) |
| "Ketamine is a noncompetitive N-methyl-D-aspartic acid receptor antagonist, making it an effective dissociative agent." | 1.46 | A Novel Agent for Management of Agitated Delirium: A Case Series of Ketamine Utilization in the Pediatric Emergency Department. ( Kopec, KT; Kowalski, JM; Lavelle, J; Osterhoudt, K, 2017) |
| "Ketamine has a rapid, predictable onset within three to four minutes when given by intramuscular (IM) injection." | 1.43 | Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System. ( Glass, DM; Hutchcraft, MG; Scaggs, TR; Weir, WB, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (20.90) | 18.7374 |
| 1990's | 3 (4.48) | 18.2507 |
| 2000's | 5 (7.46) | 29.6817 |
| 2010's | 27 (40.30) | 24.3611 |
| 2020's | 18 (26.87) | 2.80 |
| Authors | Studies |
|---|---|
| Solano, JJ | 1 |
| Clayton, LM | 1 |
| Parks, DJ | 1 |
| Polley, SE | 1 |
| Hughes, PG | 1 |
| Hennekens, CH | 1 |
| Shih, RD | 1 |
| Alter, SM | 1 |
| Liu, J | 1 |
| Yu, D | 1 |
| Li, J | 1 |
| Barreto Chang, OL | 1 |
| Kreuzer, M | 1 |
| Morgen, DF | 1 |
| Possin, KL | 1 |
| García, PS | 1 |
| Appelbaum, PS | 1 |
| Ren, X | 1 |
| Zhang, S | 1 |
| Yang, Y | 1 |
| Song, A | 1 |
| Liang, F | 1 |
| Zhang, Y | 1 |
| Dong, Y | 1 |
| Wu, X | 1 |
| Xie, Z | 1 |
| Wei, W | 1 |
| Zhang, A | 1 |
| Liu, L | 1 |
| Zheng, X | 1 |
| Tang, C | 1 |
| Zhou, M | 1 |
| Gu, Y | 1 |
| Yao, Y | 1 |
| Nathan, N | 1 |
| Jung, H | 1 |
| Lee, J | 1 |
| Ahn, HY | 1 |
| Yang, JH | 1 |
| Suh, GY | 1 |
| Ko, RE | 1 |
| Chung, CR | 1 |
| Weiss, KJ | 1 |
| Lanzillotta, C | 1 |
| Lin, Y | 1 |
| Jiang, M | 1 |
| Springer, B | 1 |
| Yip, WL | 1 |
| Rex Pui Kin, L | 1 |
| Magdalene, YT | 1 |
| Nike Kwai Cheung, L | 1 |
| Matthew Sik, HT | 1 |
| Mo, H | 1 |
| Campbell, MJ | 1 |
| Fertel, BS | 1 |
| Lam, SW | 1 |
| Wells, EJ | 1 |
| Casserly, E | 1 |
| Meldon, SW | 1 |
| Erstad, BL | 1 |
| Barletta, JF | 1 |
| Hollinger, A | 2 |
| Rüst, CA | 1 |
| Riegger, H | 2 |
| Gysi, B | 1 |
| Tran, F | 1 |
| Brügger, J | 1 |
| Huber, J | 1 |
| Toft, K | 2 |
| Surbeck, M | 1 |
| Schmid, HR | 1 |
| Rentsch, K | 1 |
| Steiner, L | 1 |
| Siegemund, M | 2 |
| Kim, HK | 1 |
| Leonard, JB | 1 |
| Corwell, BN | 1 |
| Connors, NJ | 1 |
| Zhang, J | 1 |
| Ma, L | 1 |
| Wan, X | 1 |
| Shan, J | 1 |
| Qu, Y | 1 |
| Hashimoto, K | 1 |
| Eisenach, JC | 1 |
| Avidan, MS | 2 |
| Maybrier, HR | 2 |
| Abdallah, AB | 1 |
| Jacobsohn, E | 2 |
| Vlisides, PE | 1 |
| Pryor, KO | 1 |
| Veselis, RA | 2 |
| Grocott, HP | 2 |
| Emmert, DA | 1 |
| Rogers, EM | 1 |
| Downey, RJ | 2 |
| Yulico, H | 1 |
| Noh, GJ | 1 |
| Lee, YH | 1 |
| Waszynski, CM | 1 |
| Arya, VK | 2 |
| Pagel, PS | 3 |
| Hudetz, JA | 3 |
| Muench, MR | 2 |
| Fritz, BA | 2 |
| Waberski, W | 1 |
| Inouye, SK | 2 |
| Mashour, GA | 2 |
| Ziemann, S | 1 |
| Coburn, M | 1 |
| Gonin, P | 1 |
| Beysard, N | 1 |
| Yersin, B | 1 |
| Carron, PN | 1 |
| Linder, LM | 1 |
| Ross, CA | 1 |
| Weant, KA | 1 |
| Schmitz, A | 1 |
| Weiss, M | 1 |
| Kellenberger, C | 1 |
| O'Gorman Tuura, R | 1 |
| Klaghofer, R | 1 |
| Scheer, I | 1 |
| Makki, M | 1 |
| Sabandal, C | 1 |
| Buehler, PK | 1 |
| Seifert, B | 1 |
| Blum, A | 1 |
| Zehnder, T | 1 |
| Shurtleff, V | 1 |
| Radosevich, JJ | 1 |
| Patanwala, AE | 1 |
| Hovaguimian, F | 1 |
| Tschopp, C | 1 |
| Beck-Schimmer, B | 1 |
| Puhan, M | 1 |
| Perbet, S | 2 |
| Verdonk, F | 1 |
| Godet, T | 2 |
| Jabaudon, M | 1 |
| Chartier, C | 1 |
| Cayot, S | 1 |
| Guerin, R | 1 |
| Morand, D | 1 |
| Bazin, JE | 1 |
| Futier, E | 1 |
| Pereira, B | 1 |
| Constantin, JM | 2 |
| Mion, G | 1 |
| Hayhurst, CJ | 1 |
| Farrin, E | 1 |
| Hughes, CG | 2 |
| Plyler, SS | 1 |
| Muckler, VC | 1 |
| Titch, JF | 1 |
| Gupta, DK | 1 |
| Rice, AN | 1 |
| Escallier, KE | 1 |
| Chen, Y | 1 |
| Ben Abdallah, A | 1 |
| Noh, G | 1 |
| Pryor, K | 1 |
| Kaiser, H | 1 |
| Pong, R | 1 |
| Choi, S | 1 |
| Weingart, SD | 1 |
| Trueger, NS | 1 |
| Wong, N | 1 |
| Scofi, J | 1 |
| Singh, N | 1 |
| Rudolph, SS | 1 |
| Scheppke, KA | 1 |
| Braghiroli, J | 1 |
| Shalaby, M | 1 |
| Chait, R | 1 |
| Schultz, CH | 1 |
| Wilson, JT | 1 |
| Kowalski, JM | 1 |
| Kopec, KT | 1 |
| Lavelle, J | 1 |
| Osterhoudt, K | 1 |
| Orena, EF | 1 |
| King, AB | 1 |
| Strote, J | 1 |
| Vincent, JL | 1 |
| Shehabi, Y | 1 |
| Walsh, TS | 1 |
| Pandharipande, PP | 1 |
| Ball, JA | 1 |
| Spronk, P | 1 |
| Longrois, D | 1 |
| Strøm, T | 1 |
| Conti, G | 1 |
| Funk, GC | 1 |
| Badenes, R | 1 |
| Mantz, J | 1 |
| Spies, C | 1 |
| Takala, J | 1 |
| Bornemann-Cimenti, H | 1 |
| Wejbora, M | 1 |
| Michaeli, K | 1 |
| Edler, A | 1 |
| Sandner-Kiesling, A | 1 |
| Scaggs, TR | 1 |
| Glass, DM | 1 |
| Hutchcraft, MG | 1 |
| Weir, WB | 1 |
| Patterson, KM | 1 |
| Iqbal, Z | 1 |
| Gandhi, SD | 1 |
| Byrne, AJ | 1 |
| Hudetz, AG | 1 |
| Warltier, DC | 1 |
| Treston, G | 1 |
| Bell, A | 1 |
| Cardwell, R | 1 |
| Fincher, G | 1 |
| Chand, D | 1 |
| Cashion, G | 1 |
| Chen, J | 1 |
| Li, W | 1 |
| Hu, X | 1 |
| Wang, D | 1 |
| Sharma, CV | 1 |
| Stacey, S | 1 |
| Yate, P | 1 |
| Weatherall, A | 1 |
| Venclovas, R | 1 |
| Kudoh, A | 1 |
| Grace, RF | 1 |
| Casagrande, AM | 1 |
| Currie, MA | 1 |
| Currie, AL | 1 |
| Jago, RH | 1 |
| Restall, J | 1 |
| Thompson, MC | 1 |
| Levänen, J | 1 |
| Mäkelä, ML | 1 |
| Scheinin, H | 1 |
| Gutstein, HB | 1 |
| Lilburn, JK | 2 |
| Dundee, JW | 7 |
| Nair, SG | 1 |
| Fee, JP | 1 |
| Johnston, HM | 1 |
| Houlton, PJ | 1 |
| Downing, JW | 2 |
| Brock-Utne, JG | 1 |
| Donahue, PJ | 1 |
| Dineen, PS | 1 |
| Bovill, J | 1 |
| Coppel, DL | 1 |
| Bovill, JG | 3 |
| Sussman, DR | 1 |
| Mahomedy, YH | 1 |
| Coleman, AJ | 1 |
| Mahomedy, MC | 1 |
| Albin, MS | 1 |
| Bunegin, L | 1 |
| Massopust, LC | 1 |
| Jannetta, PJ | 1 |
| Clarke, RS | 3 |
| Knox, JW | 2 |
| Pandit, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients[NCT05752409] | 120 participants (Anticipated) | Interventional | 2021-10-08 | Recruiting | |||
| The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery: a Protocol for Randomized, Double-blinded, placebo-and Positive-controlled, Non-inferiority Trial[NCT05242692] | Early Phase 1 | 780 participants (Anticipated) | Interventional | 2022-03-10 | Recruiting | ||
| Baden PRIDe Trial - Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial[NCT02433041] | Phase 4 | 200 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
| Caffeine and Neurologic Recovery Following Surgery and General Anesthesia[NCT03577730] | Early Phase 1 | 71 participants (Actual) | Interventional | 2018-07-10 | Completed | ||
| Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery：a Prospective, Multicenter, Double-blind, Randomized Controlled Trial[NCT03606941] | 1,100 participants (Actual) | Interventional | 2018-09-07 | Completed | |||
| Effectiveness and Safety of Methylene Blue for Prevention of Postoperative Neurocognitive Disorders in Patients Undergoing Pancreatic Tumor Surgery: A Prospective Randomized Controlled Clinical Trial[NCT04529265] | 314 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Analgesic Effects of Low-dose S-ketamine in Patients Undergoing Major Spine Fusion Surgery: A Double-blinded, Randomized Controlled Trial[NCT04964219] | Phase 4 | 164 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac and Nonneurosurgical Surgery[NCT04341844] | 248 participants (Actual) | Interventional | 2019-01-14 | Completed | |||
| The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial[NCT01690988] | Phase 3 | 746 participants (Actual) | Interventional | 2014-02-01 | Completed | ||
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| Comparison of The Effectiveness of Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg and 4 mcg/kg in Children Undergoing MRI at Cipto Mangunkusumo Hospital[NCT05091151] | 94 participants (Actual) | Interventional | 2019-02-01 | Completed | |||
| The Effect and Contribution of a Perioperative Ketamine Infusion in an Established Enhanced Recovery Pathway[NCT04625283] | Phase 4 | 1,544 participants (Anticipated) | Interventional | 2021-04-12 | Enrolling by invitation | ||
| Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures[NCT03442179] | 24 participants (Actual) | Observational | 2019-02-13 | Active, not recruiting | |||
| Cardiovascular and Neuropsychiatric Side Effects in Ketamine Analgesic Infusions in Acute Pain[NCT03979105] | 300 participants (Actual) | Observational | 2017-07-01 | Completed | |||
| Comparison of Ketamine 0.1 mg/kg, 0.2 mg/kg, and 0.3 mg/kg Intravenous Doses for Acute Pain in the Emergency Department: A Prospective, Randomized, Double-blind, Active-controlled, Clinical Trial[NCT03896230] | Phase 4 | 11 participants (Actual) | Interventional | 2019-05-03 | Terminated (stopped due to Due to resource limitations the study was on hold and was then terminated.) | ||
| Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.[NCT02793986] | 296 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia: a Comparison Between Intraoperative Sedation With Fentanyl, Fentanyl-dexmedetomidine and Fentanyl-propofol[NCT03120442] | 600 participants (Anticipated) | Interventional | 2017-06-14 | Enrolling by invitation | |||
| Epidemiology of Weaning From Invasive Mechanical Ventilation in COVID-19. Observational and Multicenter Study.[NCT05049200] | 326 participants (Actual) | Observational [Patient Registry] | 2020-04-01 | Completed | |||
| Southern Medical University Clinical Research Project Initiative：Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis[NCT03406494] | 800 participants (Anticipated) | Interventional | 2018-03-31 | Not yet recruiting | |||
| Impact of Night-time Dexmedetomidine-esketamine Infusion on Sleep Quality of Patients With Mechanical Ventilation in ICU: a Randomized Controlled Trial[NCT05718024] | Phase 4 | 174 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646] | Phase 4 | 154 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218] | 88 participants (Anticipated) | Interventional | 2023-10-16 | Recruiting | |||
| Efficacy of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery: A Randomized, Double-blind Trial[NCT06062550] | Phase 4 | 312 participants (Anticipated) | Interventional | 2023-10-31 | Not yet recruiting | ||
| Impact of Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia on Long-term Outcomes After Scoliosis Correction Surgery: Follow-up of a Randomized Trial[NCT06087510] | Phase 4 | 312 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| Effects of Low-dose Dexmedetomidine-esketamine Combined Nasal Administration at Night on Perioperative Sleep Quality in Breast Cancer Patients: a Randomized, Double-blind, Placebo-controlled Trial[NCT05732064] | Phase 4 | 180 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| Low-dose S-ketamine and Dexmedetomidine in Combination With Opioids for Patient-controlled Analgesia After Scoliosis Correction Surgery: a Randomized, Double-blind, Placebo-controlled Trial[NCT04791059] | Phase 4 | 200 participants (Actual) | Interventional | 2021-04-09 | Completed | ||
| ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn (stopped due to Trial never received funding.) | ||
| The Prevention of Post Operative Cognitive Dysfunction by Ketamine: a Prospective Multicenter Randomized Blinded Placebo-controlled Trial in Elderly Patients Undergoing Elective Orthopaedic Surgery[NCT02892916] | Phase 3 | 307 participants (Actual) | Interventional | 2017-03-20 | Completed | ||
| Positive Imagery Therapy and the Incidence of Emergence Reactions With the Use of Ketamine[NCT04746079] | 180 participants (Anticipated) | Interventional | 2021-02-05 | Recruiting | |||
| [NCT01506622] | 222 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| Total Intravenous Anesthesia With Remifentanil-propofol Admixture Using Single-infusion Technique[NCT04394897] | 96 participants (Actual) | Observational | 2013-03-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Behavioral Pain Scale, on a scale ranging from 3 to 12 when 3 is no pain and 12 is maximum pain (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 3 |
| Control | 3 |
Visual Analogue Scale (mm, 0-100, 0 = no pain, 100 = worst pain imaginable) (NCT03577730)
Timeframe: Data gathered from postoperative day 0-3. Final results were based on all values combined over this time period, per protocol.
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 40 |
| Control | 39 |
Trail Making Test scores (seconds, 10-300,10 = fastest reported completion, 300 = maximum time allowed for completion). The change was calculated from the value at post anesthesia minus value at baseline. Higher values are considered to be worse outcomes. (NCT03577730)
Timeframe: morning of surgery baseline compared to postanesthesia care unit. Postanesthesia care unit measurement approximately 60 minutes after end of surgery
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 10 |
| Control | 16 |
Postoperative opioid consumption, oral morphine equivalents (mg) (NCT03577730)
Timeframe: through postoperative day 3
| Intervention | oral morphine equivalents (mg) (Median) |
|---|---|
| Experimental | 77 |
| Control | 51 |
Negative Affect Score (n, 10-50, 10 = least negative affect, 50 = most negative affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 12 |
| Control | 12 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-A) (n, 0-21, 0 = normal, 21 = presence of severe anxiety symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 2 |
Number (n) of participants with positive screens (score ≥8) using the Hospitalized Anxiety and Depression Scale (HADS-D) (n, 0-21, 0 = normal, 21 = presence of severe depression symptoms) (NCT03577730)
Timeframe: baseline through postoperative day 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 2 |
| Control | 1 |
Number (n) of participants who has experienced at least one episode of delirium by the postoperative day 3 time point, as determined by daily Confusion Assessment Method (CAM). (NCT03577730)
Timeframe: By afternoon of postoperative day (POD) 3
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental | 7 |
| Control | 14 |
Positive Affect Score (n, 10-50, 10 = least positive affect, 50 = most positive affect) via PANAS (Positive and Negative Affect Schedule) (NCT03577730)
Timeframe: postoperative day 3
| Intervention | score on a scale (Median) |
|---|---|
| Experimental | 35 |
| Control | 35 |
Self-report instrument for measuring sleep quality. Visual Analogue Scale (mm, 0-100, 0 =Deep sleep , 100 =Light sleep) (NCT03577730)
Timeframe: Preoperative (once before surgery on day of surgery)
| Intervention | score on a scale (Mean) |
|---|---|
| Experimental | 58 |
| Control | 56 |
Time from surgical dressing on to anesthetic emergence (min) (NCT03577730)
Timeframe: Duration of time from surgical dressing completion to anesthetic emergence (min); generally expected to be between 10 and 60 minutes
| Intervention | Minutes (Median) |
|---|---|
| Experimental | 8 |
| Control | 10 |
Assessed via Confusion Assessment Method or Confusion Assessment Method for Intensive Care Unit (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 45 |
| Normal Saline (Placebo) | 40 |
| Ketamine (1 mg/kg) | 62 |
Assessed via Confusion Assessment Method or Confusion Assessment Method for Intensive care Unit (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 27 |
| Normal Saline (Placebo) | 18 |
| Ketamine (1 mg/kg) | 34 |
"Assessed from patients' medical charts. All morphine equivalent drugs consumed by patients perioperatively~Opioid Drugs included:~* Postoperatively while still in hospital, the list of pain medication used included Morphine, Hydromorphone, Meperidine, Nalbuphine, Oxycodone,Oxymorphone, Tramadol, bupivacaine, (Codeine, Fentanyl, Naloxone) Total Opiates (Morphine Equivalent) in milligrams The median(IQR) opioid consumption was compared across the three study groups Placebo vs. Lo-K (0.5 mg/kg) vs. Hi-K (1 mg/kg)" (NCT01690988)
Timeframe: Postoperative days 0-3
| Intervention | mg (Median) |
|---|---|
| Ketamine (0.5 mg/kg) | 88.9 |
| Normal Saline (Placebo) | 94.7 |
| Ketamine (1 mg/kg) | 78.7 |
"According to Confusion Assessment Method or Confusion Assessment Method for Intensive Care Unit criteria the number of patients that had any positive CAM on any day for all patients. The main effect evaluated will be to determine whether ketamine decreases delirium, table 3 of the protocol provides a useful guide for the potential findings of the current study with their implications.~To further clarify, delirium will be assessed on the day of surgery, when possible and on the subsequent three days POD 1-3, as long as as patients remain in the hospital and are assessable (i.e., not sedated to a RASS <-3). The assessments on POD 1-3 will be done twice daily, once in the morning and once in the afternoon. The primary outcome of the study includes only the delirium incidence on POD 1-3.~The primary comparison will be between the combined ketamine groups and the placebo group." (NCT01690988)
Timeframe: Delirium incidence on postoperative days 1-3, calculated by any positive CAM on any day for all patients
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg and 1 mg/kg) | 85 |
| Normal Saline (Placebo) | 43 |
"Assessed from patient-reported postoperative nausea and vomiting section of Behavioral Pain Scale or Behavioral Pain Scale (Non-Intubated) Patients where asked whether they currently have nausea/vomiting AM & PM the response choices: None, Mild, Moderate, Severe Incidence of nauseavomiting accounted for any positive reporting(Mild, moderate, or sever) Daily incidence accounted for any positive incidence AM/PM in each POD Any POD nausea/vomiting reports the incidence across day 1-3~The incidence of nausea and or vomiting was compared across the three study groups Placebo vs. Lo-K (0.5 mg/kg) vs. Hi-K (1 mg/kg) for POD 1-3 and overall." (NCT01690988)
Timeframe: Postoperative days 1-3
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketamine (0.5 mg/kg) | 72 |
| Normal Saline (Placebo) | 73 |
| Ketamine (1 mg/kg) | 64 |
Assessed by observer-based Behavioral Pain Scale or Behavioral Pain Scale (Non-Intubated) with subsequent administration of patient-reported Visual Analog Scale The behavioral pain scale has three domains and ranges from 3 to 15. The visual analog scale is a continuous scale from 0 to 100 mm. Daily Maximum Pain accounted for pain level in the AM or PM for both the VAS and the BPS/BPS-NI a higher value means a worse outcome. (NCT01690988)
Timeframe: Postoperative days 1-3, two assessment daily (morning and afternoon), with at least six hours between assessments
| Intervention | participants (Median) | |||||
|---|---|---|---|---|---|---|
| VAS day 1 | VAS day 2 | VAS day 3 | BPS/BPS-NI day 1 | BPS/BPS-NI 2 | BPS/BPS-NI 3 | |
| Ketamine (0.5 mg/kg ) | 70 | 56 | 46 | 4 | 4 | 3 |
| Ketamine (1 mg/kg) | 68 | 57.5 | 47 | 4 | 3 | 3 |
| Normal Saline (Placebo) | 63.5 | 59 | 52.5 | 4 | 3 | 3 |
"Frequency of adverse events secondary to ketamine including fatigue, dizziness, nausea, headache, feeling of unreality, changes in hearing or vision, mood changes, generalized discomfort, and hallucinations, changes in vital signs.~Adverse events were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| at 15 min post infusion | at 30 min post infusion | at 60 min post infusion | at 90 min post infusion | at 120 min post infusion | |
| Arm 1: 0.1 mg/kg Ketamine | 2 | 1 | 1 | 1 | 1 |
| Arm 1: 0.2 mg/kg Ketamine | 3 | 2 | 2 | 2 | 0 |
| Arm 1: 0.3 mg/kg Ketamine | 2 | 1 | 0 | 0 | 0 |
"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline pain score | Pain score at 15 min | Pain score at 30 min | Pain score at 60 min | Pain score at 90 min | |
| Arm 1: 0.3 mg/kg Ketamine | 7.5 | 2 | 6 | 5 | 2 |
| Arm 1: 0.2 mg/kg Ketamine | 8.5 | 6 | 5.75 | 7 | 7 |
"Pain score using Numerical Rating Scale (NRS) post ketamine infusion. The Numerical Rating Scale (NRS) ranges from 0-to-10 with 0 being no pain and lower numbers representing less pain, so in this case lower numbers will represent better outcomes.~Pain scores were reported at baseline and then at 15 min/30 min/60 min/90 min and 120 minutes post-infusion." (NCT03896230)
Timeframe: Within 2 hours post infusion completion
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Baseline pain score | Pain score at 15 min | Pain score at 30 min | Pain score at 60 min | Pain score at 90 min | Pain score at 120 min | |
| Arm 1: 0.1 mg/kg Ketamine | 9.4 | 5.25 | 5.25 | 5.25 | 4.5 | 4 |
8 reviews available for ketamine and Delirium of Mixed Origin
| Article | Year |
|---|---|
Hyperactive Delirium with Severe Agitation.
Topics: Delirium; Emergency Service, Hospital; Humans; Hypnotics and Sedatives; Ketamine; Psychomotor Agitat | 2024 |
Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Benzodiazepines; Critical Illness; Deep Sed | 2020 |
Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium.
Topics: Acute Disease; Aggression; Antipsychotic Agents; Benzodiazepines; Delirium; Emergency Service, Hospi | 2021 |
Excited Delirium: A Systematic Review.
Topics: Antipsychotic Agents; Delirium; Female; Humans; Ketamine; Male; Psychomotor Agitation; Retrospective | 2018 |
Ketamine for the Acute Management of Excited Delirium and Agitation in the Prehospital Setting.
Topics: Algorithms; Delirium; Emergency Medical Services; Excitatory Amino Acid Antagonists; Humans; Ketamin | 2018 |
Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis.
Topics: Anesthetics, Dissociative; Cognitive Dysfunction; Delirium; Humans; Intraoperative Care; Ketamine; P | 2018 |
The role of anesthesia in the prevention of postoperative delirium: a systematic review.
Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics; Antipsychotic Agents; Checklist; Delirium; Dexame | 2016 |
The role of anesthesia in the prevention of postoperative delirium: a systematic review.
Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics; Antipsychotic Agents; Checklist; Delirium; Dexame | 2016 |
The role of anesthesia in the prevention of postoperative delirium: a systematic review.
Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics; Antipsychotic Agents; Checklist; Delirium; Dexame | 2016 |
The role of anesthesia in the prevention of postoperative delirium: a systematic review.
Topics: Analgesics, Non-Narcotic; Anesthesia; Anesthetics; Antipsychotic Agents; Checklist; Delirium; Dexame | 2016 |
Comfort and patient-centred care without excessive sedation: the eCASH concept.
Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Conscious Sedation; Critical Care; Deep Sedation; De | 2016 |
Comfort and patient-centred care without excessive sedation: the eCASH concept.
Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Conscious Sedation; Critical Care; Deep Sedation; De | 2016 |
Comfort and patient-centred care without excessive sedation: the eCASH concept.
Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Conscious Sedation; Critical Care; Deep Sedation; De | 2016 |
Comfort and patient-centred care without excessive sedation: the eCASH concept.
Topics: Analgesia; Analgesics, Opioid; Benzodiazepines; Conscious Sedation; Critical Care; Deep Sedation; De | 2016 |
16 trials available for ketamine and Delirium of Mixed Origin
43 other studies available for ketamine and Delirium of Mixed Origin
| Article | Year |
|---|---|
Prehospital Ketamine Administration for Excited Delirium with Illicit Substance Co-Ingestion and Subsequent Intubation in the Emergency Department.
Topics: Adolescent; Delirium; Eating; Emergency Service, Hospital; Humans; Intubation, Intratracheal; Ketami | 2021 |
Comment on:"Ketamine vs haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial".
Topics: Cognitive Dysfunction; Delirium; Double-Blind Method; Haloperidol; Humans; Ketamine | 2022 |
Ketamine-Associated Intraoperative Electroencephalographic Signatures of Elderly Patients With and Without Preoperative Cognitive Impairment.
Topics: Aged; Analgesics, Non-Narcotic; Cognitive Dysfunction; Delirium; Electroencephalography; Female; Hum | 2022 |
Excited Delirium, Ketamine, and Deaths in Police Custody.
Topics: Delirium; Humans; Ketamine; Law Enforcement; Male; Police; Restraint, Physical | 2022 |
Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking.
Topics: Animals; Delirium; Endosomes; Ketamine; Mice; Neurons; tau Proteins | 2023 |
Ketamine and the At-Risk Brain.
Topics: Anesthetics; Brain; Delirium; Humans; Ketamine; Postoperative Complications | 2022 |
Safety and feasibility of continuous ketamine infusion for analgosedation in medical and cardiac ICU patients who received mechanical ventilation support: A retrospective cohort study.
Topics: Adult; Analgesics; Analgesics, Opioid; Antipsychotic Agents; Delirium; Feasibility Studies; Fentanyl | 2022 |
The Case Against "Excited Delirium".
Topics: Death, Sudden; Delirium; Humans; Ketamine; Police; Problem Behavior | 2023 |
Tiletamine detected in a ketamine abuser with altered mental status.
Topics: Adult; Delirium; Humans; Ketamine; Male; Substance-Related Disorders; Tiletamine | 2020 |
Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience.
Topics: Adult; Analgesia; Anesthetics, Dissociative; Conscious Sedation; Delirium; Emergency Service, Hospit | 2020 |
(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation.
Topics: Animals; Cytokines; Delirium; Endotoxins; Ketamine; Lipopolysaccharides; Maze Learning; Mice | 2021 |
Ketamine fails to prevent postoperative delirium.
Topics: Delirium; Humans; Ketamine; Postoperative Complications | 2017 |
[Comment on: ketamine for prevention of postoperative delirium and pain].
Topics: Analgesics; Delirium; Humans; Ketamine; Pain; Pain, Postoperative; Postoperative Complications | 2017 |
Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit.
Topics: Academic Medical Centers; Aged; Coma; Critical Care Outcomes; Delirium; Dexmedetomidine; Female; Hum | 2020 |
Ketamine infusions for sedation in ICU.
Topics: Conscious Sedation; Delirium; Double-Blind Method; Humans; Intensive Care Units; Ketamine; Respirati | 2019 |
The effect of ketamine on delirium and opioid-induced hyperalgesia in the Intensive Care Unit.
Topics: Analgesics, Opioid; Critical Care; Delirium; Humans; Hyperalgesia; Hypnotics and Sedatives; Intensiv | 2018 |
Low-Dose Ketamine Infusion to Decrease Postoperative Delirium for Spinal Fusion Patients.
Topics: Aged; Analgesics; Analgesics, Opioid; Delirium; Female; Humans; Incidence; Ketamine; Male; Middle Ag | 2019 |
Ketamine infusion for sedation in ICU, response to Dr Mion.
Topics: Conscious Sedation; Delirium; Double-Blind Method; Humans; Intensive Care Units; Ketamine; Respirati | 2019 |
Delayed sequence intubation: a prospective observational study.
Topics: Adolescent; Adult; Aged; Anesthetics, Dissociative; Conscious Sedation; Delirium; Emergency Service, | 2015 |
Prehospital use of i.m. ketamine for sedation of violent and agitated patients.
Topics: Anesthetics, Dissociative; Dangerous Behavior; Delirium; Emergency Medical Services; Emergency Medic | 2014 |
Prehospital use of i.m. ketamine for sedation of violent and agitated patients.
Topics: Anesthetics, Dissociative; Dangerous Behavior; Delirium; Emergency Medical Services; Emergency Medic | 2014 |
Prehospital use of i.m. ketamine for sedation of violent and agitated patients.
Topics: Anesthetics, Dissociative; Dangerous Behavior; Delirium; Emergency Medical Services; Emergency Medic | 2014 |
Prehospital use of i.m. ketamine for sedation of violent and agitated patients.
Topics: Anesthetics, Dissociative; Dangerous Behavior; Delirium; Emergency Medical Services; Emergency Medic | 2014 |
Ketamine for pre-hospital control of agitated delirious patients: promising but not yet ready for prime time.
Topics: Anesthetics, Dissociative; Delirium; Emergency Medical Services; Emergency Medical Technicians; Huma | 2014 |
Pharmacologic, physiologic, and psychological characteristics associated with emergence delirium in combat veterans.
Topics: Adult; Age Factors; Anesthesia; Anesthetics; Brain Injuries; Combat Disorders; Delirium; Female; Hum | 2014 |
A Novel Agent for Management of Agitated Delirium: A Case Series of Ketamine Utilization in the Pediatric Emergency Department.
Topics: Adolescent; Anesthetics, Dissociative; Delirium; Emergency Service, Hospital; Female; Humans; Inject | 2017 |
Caution When Using the Term and Diagnosis of Agitated Delirium.
Topics: Delirium; Diagnostic Errors; Emergency Service, Hospital; Humans; Ketamine; Psychomotor Agitation; R | 2016 |
Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System.
Topics: Adolescent; Adult; Delirium; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Female; | 2016 |
Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System.
Topics: Adolescent; Adult; Delirium; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Female; | 2016 |
Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System.
Topics: Adolescent; Adult; Delirium; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Female; | 2016 |
Prehospital Ketamine is a Safe and Effective Treatment for Excited Delirium in a Community Hospital Based EMS System.
Topics: Adolescent; Adult; Delirium; Emergency Service, Hospital; Excitatory Amino Acid Antagonists; Female; | 2016 |
What is the nature of the emergence phenomenon when using intravenous or intramuscular ketamine for paediatric procedural sedation?
Topics: Adolescent; Anesthesia Recovery Period; Anesthetics, Dissociative; Australia; Child; Child, Preschoo | 2009 |
Reducing post-cardiopulmonary bypass delirium: more ketamine or less etomidate?
Topics: Cardiac Surgical Procedures; Cardiopulmonary Bypass; Delirium; Humans; Ketamine; Male; Postoperative | 2011 |
Experience with a propofol-ketamine mixture for sedation during pediatric orthopedic surgery.
Topics: Adolescent; Anesthesia Recovery Period; Anesthesia, Conduction; Anesthetics, Combined; Anesthetics, | 2010 |
Hypnosis first, then dissociation.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Delirium; Hallucinations; Humans; Hypnosis; Ket | 2003 |
Propofol for office oral and maxillofacial anesthesia: the case against low-dose ketamine.
Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Dissoci | 2006 |
Ketamine: effect of literacy on emergence phenomena.
Topics: Adolescent; Adult; Afghanistan; Anesthesia, Intravenous; Delirium; Educational Status; Female; Hallu | 1984 |
Ketamine and military anaesthesia. The effect of heavy papaveretum premedication and Althesin induction on the incidence of emergence phenomena.
Topics: Adult; Alfaxalone Alfadolone Mixture; Anesthesia Recovery Period; Delirium; Humans; Ketamine; Milita | 1984 |
Potential physiologic mechanism for ketamine-induced emergence delirium.
Topics: Anesthetics, Dissociative; Brain; Delirium; Humans; Ketamine | 1996 |
Ketamine sequelae. Evaluation of the ability of various premedicants to attenuate its psychic actions.
Topics: Analgesics, Opioid; Anesthesia, Intravenous; Delirium; Female; Humans; Hypnotics and Sedatives; Keta | 1978 |
Ketamine-iorazepam. Attenuation of psychic sequelae of ketamine by lorazepam.
Topics: Adult; Anesthesia, Intravenous; Anti-Anxiety Agents; Delirium; Female; Humans; Ketamine; Lorazepam; | 1978 |
Intravenous ketamine anaesthesia for major abdominal surgery--an assessment of a technique and the influence of ataractic drugs on the psychomimetic effects of ketamine.
Topics: Abdomen; Adult; Cognition Disorders; Delirium; Female; Hallucinations; Humans; Injections, Intraveno | 1978 |
Human growth hormone.
Topics: Delirium; Growth Disorders; Growth Hormone; Humans; Injections, Intravenous; Ketamine | 1977 |
Emergence delirium following oral ketamine.
Topics: Administration, Oral; Child, Preschool; Delirium; Female; Humans; Ketamine; Preanesthetic Medication | 1992 |
A comparative evaluation of ketamine anesthesia in children and adults.
Topics: Adolescent; Adult; Age Factors; Airway Obstruction; Analgesia; Anesthesia, General; Anesthesia, Intr | 1974 |
Ketamine-induced postanesthetic delirium attenuated by tetrahydroaminoacridine.
Topics: Acridines; Analysis of Variance; Anesthesia, Intravenous; Animals; Delirium; Disease Models, Animal; | 1974 |
The effect of dosage and premedication on the action of ketamine.
Topics: Analgesics; Anesthesia, General; Anesthetics; Atropine; Blood Pressure; Cyclohexanes; Delirium; Diaz | 1970 |
Clinical studies of induction agents. XXXVI: Ketamine.
Topics: Adult; Analgesics; Anesthesia, Intravenous; Anesthetics; Atropine; Attitude to Health; Blood Pressur | 1970 |
Problems with ketamine in adults.
Topics: Adult; Anesthetics; Benperidol; Cyclohexanes; Delirium; Diazepam; Humans; Hypertension; Injections, | 1971 |