Page last updated: 2024-08-05 11:54:38
oxetanes
Any oxacycle that is oxetane or its substituted derivatives.
ChEBI ID: 38784
Members (4)
Member | Definition | Role |
---|---|---|
AZD1979 | A carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist. | AZD1979 |
crenolanib | A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia. | crenolanib |
oxetane | A saturated organic heteromonocyclic parent that is a four-membered ring comprising of three carbon atoms and an oxygen atom. | oxetane |
oxetanocin a | A nucleoside analogue found in Bacillus megaterium in which an adenine moiety is attached to position 2 of a of an oxetane ring which is substituted at positions 3 and 4 by hydroxymethyl groups. | oxetanocin A |
Research
Studies (274)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 10 (3.65) | 18.7374 |
1990's | 20 (7.30) | 18.2507 |
2000's | 65 (23.72) | 29.6817 |
2010's | 136 (49.64) | 24.3611 |
2020's | 43 (15.69) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 4 (1.45%) | 5.53% |
Reviews | 20 (7.27%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 251 (91.27%) | 84.16% |