ketamine has been researched along with Hypovolemic in 7 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate and compare the cardiopulmonary effects of induction of anesthesia with isoflurane (Iso), ketamine-diazepam (KD), or propofol-diazepam (PD) in hypovolemic dogs." | 9.14 | The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog. ( Dyson, DH; Fayyaz, S; Kerr, CL; Mirakhur, KK, 2009) |
| "To assess whether subarachnoid ketamine has fewer hemodynamic effects than lidocaine in normal and hypovolemic pigs and to determine whether or not the effects of ketamine are dose-dependent." | 7.72 | [Ketamine for subarachnoid anesthesia during hypovolemia: preliminary study in pigs]. ( Errando, CL; Gil, F; López-Alarcón, D; Moliner, S; Peiró, CM; Sifre, C; Valía, JC, 2004) |
| " We reviewed and evaluated the current literature and identified 29 cases of DI related to medications commonly used in anesthesia such as propofol, dexmedetomidine, sevoflurane, ketamine, and opioids." | 5.22 | Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature. ( Harbell, MW; Kosiorek, HE; Kraus, MB; Reynolds, EG; Sharpe, EE; Van Decar, LM, 2022) |
| "To evaluate and compare the cardiopulmonary effects of induction of anesthesia with isoflurane (Iso), ketamine-diazepam (KD), or propofol-diazepam (PD) in hypovolemic dogs." | 5.14 | The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog. ( Dyson, DH; Fayyaz, S; Kerr, CL; Mirakhur, KK, 2009) |
| "To assess whether subarachnoid ketamine has fewer hemodynamic effects than lidocaine in normal and hypovolemic pigs and to determine whether or not the effects of ketamine are dose-dependent." | 3.72 | [Ketamine for subarachnoid anesthesia during hypovolemia: preliminary study in pigs]. ( Errando, CL; Gil, F; López-Alarcón, D; Moliner, S; Peiró, CM; Sifre, C; Valía, JC, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| David, EM | 1 |
| Pacharinsak, C | 1 |
| Jampachaisri, K | 1 |
| Hagan, L | 1 |
| Marx, JO | 1 |
| Huang, M | 1 |
| Watso, JC | 1 |
| Moralez, G | 1 |
| Cramer, MN | 1 |
| Hendrix, JM | 1 |
| Yoo, JK | 1 |
| Badrov, MB | 1 |
| Fu, Q | 1 |
| Hinojosa-Laborde, C | 1 |
| Crandall, CG | 1 |
| Van Decar, LM | 1 |
| Reynolds, EG | 1 |
| Sharpe, EE | 1 |
| Harbell, MW | 1 |
| Kosiorek, HE | 1 |
| Kraus, MB | 1 |
| Berthelsen, LF | 1 |
| Fayyaz, S | 1 |
| Kerr, CL | 1 |
| Dyson, DH | 1 |
| Mirakhur, KK | 1 |
| Bouchut, JC | 1 |
| Teyssedre, S | 1 |
| Errando, CL | 1 |
| Sifre, C | 1 |
| Moliner, S | 1 |
| López-Alarcón, D | 1 |
| Valía, JC | 1 |
| Gil, F | 1 |
| Peiró, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine[NCT03621085] | Phase 4 | 43 participants (Actual) | Interventional | 2018-06-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Tolerance to a simulated hemorrhagic challenge will be assessed, for both the placebo and ketamine limbs, by causing progressive central hypovolemia via lower-body negative pressure (LBNP). This progressive lower-body negative pressure challenge will be performed until the onset of syncopal symptoms (defined as: profound bradycardia, a precipitous drop in arterial blood pressure and accompanying narrowing of pulse pressure, a sustained systolic blood pressure less than 80 mmHg, and/or subjective symptoms such as light-headedness, sweating, nausea, or dizziness). The primary variable will be the quantification of lower-body negative pressure that is required to cause these symptoms. This quantification will be objectively measured via a cumulative stress index which is calculated as the sum of the product of the LBNP level and the duration of each level, until test termination (i.e., 40 mmHg x 3 min + 50 mmHg x 3 min, etc). (NCT03621085)
Timeframe: 12 month
| Intervention | mmHg x minutes (Mean) |
|---|---|
| Ketamine | 635 |
| Placebo | 649 |
Pain assessments will be conducted using a digital algometer to obtain maximum pain thresholds caused by pressure. This pain assessment technique is conducted by applying the tip of a hand-held digital algometer on the subject's digit. Force is gradually increased and the peak force is recorded when the subject first reports a painful sensation. Removal of the pressure from the algometer immediately relieves the painful sensation and the subject can voluntarily stop the test at any time. This assessment will be performed after the subject has received placebo and ketamine. (NCT03621085)
Timeframe: 12 months
| Intervention | Kilograms (Mean) |
|---|---|
| Ketamine | 3.3 |
| Placebo | 1.6 |
1 review available for ketamine and Hypovolemic
| Article | Year |
|---|---|
Perioperative Diabetes Insipidus Caused by Anesthetic Medications: A Review of the Literature.
Topics: Anesthesia; Anesthetics; Dexmedetomidine; Diabetes Insipidus; Electrolytes; Humans; Hypovolemia; Inc | 2022 |
2 trials available for ketamine and Hypovolemic
| Article | Year |
|---|---|
Low-dose ketamine affects blood pressure, but not muscle sympathetic nerve activity, during progressive central hypovolemia without altering tolerance.
Topics: Blood Pressure; Female; Heart Rate; Humans; Hypovolemia; Ketamine; Lower Body Negative Pressure; Mal | 2020 |
The cardiopulmonary effects of anesthetic induction with isoflurane, ketamine-diazepam or propofol-diazepam in the hypovolemic dog.
Topics: Anesthesia; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, | 2009 |
4 other studies available for ketamine and Hypovolemic
| Article | Year |
|---|---|
Use of Ketamine or Xylazine to Provide Balanced Anesthesia with Isoflurane in C57BL/6J Mice.
Topics: Anesthetics, Inhalation; Animals; Balanced Anesthesia; Crystalloid Solutions; Female; Hypovolemia; H | 2022 |
Ketamine: yay or neigh? Implications for cardiovascular regulation and considerations for field use.
Topics: Blood Pressure; Humans; Hypovolemia; Ketamine; Muscles; Sympathetic Nervous System | 2021 |
[About recommendations and experience in emergency paediatric anaesthesia].
Topics: Anesthesia; Anesthetics; Anesthetics, Dissociative; Child; Drainage; Emergency Medical Services; Gui | 2011 |
[Ketamine for subarachnoid anesthesia during hypovolemia: preliminary study in pigs].
Topics: Anesthesia, Spinal; Anesthetics, Dissociative; Animals; Hemodynamics; Hypovolemia; Ketamine; Random | 2004 |