Compounds > ketamine
Page last updated: 2024-10-29

ketamine and Neuromuscular Blockade

ketamine has been researched along with Neuromuscular Blockade in 10 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.

Research Excerpts

ExcerptRelevanceReference
"5 mg/kg could improve intubating conditions for tracheal intubation without neuromuscular blockade and preserve hemodynamic stability during sevoflurane inhalation induction with alfentanil in children."9.15The effect of ketamine on tracheal intubating conditions without neuromuscular blockade during sevoflurane induction in children. ( Kim, JY; Kim, KM; Kim, KS; Kwak, HJ; Lee, SY; Min, SK, 2011)
"Propofol or remifentanil anesthesia was associated with a higher incidence of OCR during pediatric strabismus surgery than sevoflurane and desflurane anesthesia, when either ketamine or midazolam was used as an induction agent."5.14Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery. ( Choi, SR; Chung, CJ; Lee, JH; Lee, SC; Park, SW, 2009)
"In this large, pediatric multicenter registry, fentanyl, midazolam, and ketamine were the most commonly used induction agents, and the majority of tracheal intubations involved neuromuscular blockade."3.81Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. ( Brown, CA; Howell, JD; Hsing, DD; Montgomery, V; Nadkarni, VM; Nishisaki, A; Parker, MM; Tarquinio, KM; Turner, DA; Walls, RM, 2015)
"Rocuronium 0."2.68Thiopental-rocuronium versus ketamine-rocuronium for rapid-sequence intubation in parturients undergoing cesarean section. ( Assaf, BA; Baraka, AS; Sayyid, SS, 1997)
"Intubation of the trachea and mechanical ventilation are ubiquitous painful procedures in the neonatal intensive care unit that are poorly assessed and treated."2.49Sedation and analgesia to facilitate mechanical ventilation. ( Colby, CE; Nemergut, ME; Yaster, M, 2013)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nemergut, ME1
Yaster, M1
Colby, CE1
Tarquinio, KM1
Howell, JD1
Montgomery, V1
Turner, DA1
Hsing, DD1
Parker, MM1
Brown, CA1
Walls, RM1
Nadkarni, VM1
Nishisaki, A1
Kudchadkar, SR1
Shaffner, DH1
Kim, MH1
Oh, AY1
Han, SH1
Kim, JH1
Hwang, JW1
Jeon, YT1
Choi, SR1
Park, SW1
Lee, JH1
Lee, SC1
Chung, CJ1
Kim, KS1
Kwak, HJ1
Min, SK1
Lee, SY1
Kim, KM1
Kim, JY1
Messieha, ZS1
Guirguis, S1
Hanna, S1
Kimura, F1
Wada, M1
Kudo, T1
Hashimoto, H1
Ishihara, H1
Hirota, K1
Baraka, AS1
Sayyid, SS1
Assaf, BA1
Whitsel, BL1
Favorov, O1
Delemos, KA1
Lee, C1
Tommerdahl, M1
Essick, GK1
Nakhle, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium[NCT02483611]Phase 448 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Duration

"The clinical duration is the elapsed time for T1 recovery = 25% (Dur25%) of the original value of T1 after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Median)
Group M82.68
Group ML86.33
Group C64.8

Final Recovery Index

"The final recovery index is the elapsed time between the T1 recovery = 25% (Dur25%) and T4 / T1 = 80% (TOF = 80%) after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M27.97
Group ML33.81
Group C21.51

HR - M1 (Heart Rate in the Moment 1)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The measure of heart rate was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of heart rate was performed when the patient arrived in the operating room

Interventionbeats/min (Mean)
Group M79.94
Group ML77.25
Group C73.66

HR - M2 (Heart Rate in the Moment 2)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before induction of anesthesia

Interventionbeats/min (Mean)
Group M74.69
Group ML73.69
Group C75.40

HR - M3 (Heart Rate in the Moment 3)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)

Interventionbeats/min (Mean)
Group M72.94
Group ML74.19
Group C75.40

HR - M4 (Heart Rate in the Moment 4)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the end of the study solutions infusion. This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of heart rate was performed five minutes after M3 (in the end of the X and Y solutions infusion)

Interventionbeats/min (Mean)
Group M71.94
Group ML72.25
Group C65.07

HR - M5 (Heart Rate in the Moment 5)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the tracheal intubation

Interventionbeats/min (Mean)
Group M67.56
Group ML69.31
Group C64.27

HR - M6 (Heart Rate in the Moment 6)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of heart rate was performed one minute after the tracheal intubation

Interventionbeats/min (Mean)
Group M66.50
Group ML68.19
Group C65.13

HR - M7a (Heart Rate in the Moment 7a)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 15 minutes after the traqueal intubation.This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of heart rate was performed 15 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M68.94
Group ML68.19
Group C67.13

HR - M7b (Heart Rate in the Moment 7b)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of heart rate was performed 30 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M67.44
Group ML68.38
Group C64.00

HR - M7c (Heart Rate in the Moment 7c)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of heart rate was performed 45 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M65.75
Group ML65.75
Group C62.33

HR - M7d (Heart Rate in the Moment 7d)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of heart rate was performed 60 minutes after the traqueal intubation

Interventionbeats/min (Mean)
Group M66.19
Group ML65.31
Group C61.93

HR - M7e (Heart Rate in the Moment 7e)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of heart rate was performed 75 minutes after the traqueal intubation

Interventionbeats/min (Median)
Group M66.50
Group ML63.00
Group C58.00

HR - M7f (Heart Rate in the Moment 7f)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of heart rate was performed 90 minutes after the traqueal intubation

Interventionbeats/min (Median)
Group M66.00
Group ML61.00
Group C61.00

Latency

"The latency is computed as the elapsed time to reduce the response of T1 to 5% of the initial contraction force after the infusion of cisatracurium.~This outcome meansure was presented in seconds." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionseconds (Mean)
Group M139.70
Group ML151.30
Group C147.80

MAP - M1 (Mean Arterial Pressure in the Moment 1)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed when the patient arrived in the operating room

InterventionmmHg (Mean)
Group M94.63
Group ML88.75
Group C100.10

MAP - M2 (Mean Arterial Pressure in the Moment 2)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before induction of anesthesia

InterventionmmHg (Mean)
Group M87.63
Group ML84.69
Group C92.47

MAP - M3 (Mean Arterial Pressure in the Moment 3)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)

InterventionmmHg (Mean)
Group M75.88
Group ML73.88
Group C76.73

MAP - M4 (Mean Arterial Pressure in the Moment 4)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the end of the study solutions infusion.This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed five minutes after M3 (in the end of the X and Y solutions infusion)

InterventionmmHg (Median)
Group M69.00
Group ML63.00
Group C74.00

MAP - M5 (Mean Arterial Pressure in the Moment 5)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the tracheal intubation

InterventionmmHg (Median)
Group M62.50
Group ML61.50
Group C67.00

MAP - M6 (Mean Arterial Pressure in the Moment 6)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed one minute after the tracheal intubation

InterventionmmHg (Median)
Group M64.50
Group ML64.00
Group C69.00

MAP - M7a (Mean Arterial Pressure in the Moment 7a)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 15 minutes after the traqueal intubation. This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 15 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M66.00
Group ML61.50
Group C69.00

MAP - M7b (Mean Arterial Pressure in the Moment 7b)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 30 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M66.50
Group ML63.50
Group C68.00

MAP - M7c (Mean Arterial Pressure in the Moment 7c)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 45 minutes after the traqueal intubation

InterventionmmHg (Mean)
Group M69.25
Group ML63.00
Group C69.00

MAP - M7d (Mean Arterial Pressure in the Moment 7d)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 60 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M68.00
Group ML62.00
Group C66.00

MAP - M7e (Mean Arterial Pressure in the Moment 7e)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 75 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M68.00
Group ML66.00
Group C69.00

MAP - M7f (Mean Arterial Pressure in the Moment 7f)

In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 90 minutes after the traqueal intubation

InterventionmmHg (Median)
Group M64.00
Group ML64.50
Group C72.00

Recovery Index

"The recovery index is the elapsed time between the T1 recovery =25% (Dur25%) and T1 =75% (Dur75%) after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M20.08
Group ML20.26
Group C14.53

Spontaneous Recovery (T4/T1=90%)

"Spontaneous recovery is the elapsed time for the recovery of the TOF (T4 / T1) response to 90% of the original after infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: The participants were followed during the anesthetic - surgical procedure

Interventionminutes (Mean)
Group M120.20
Group ML126.70
Group C90.03

Total Duration (Dur95%)

"The total duration is the elapsed time for T1 recovery of the response to reach 95% of the initial after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes

Interventionminutes (Mean)
Group M113.20
Group ML120.10
Group C88.19

Reviews

1 review available for ketamine and Neuromuscular Blockade

ArticleYear
Sedation and analgesia to facilitate mechanical ventilation.
    Clinics in perinatology, 2013, Volume: 40, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Benzodiazepines; Clonidine; Humans; Hypnotics and Sedatives; Infant;

2013

Trials

4 trials available for ketamine and Neuromuscular Blockade

ArticleYear
The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial.
    Journal of clinical anesthesia, 2015, Volume: 27, Issue:7

    Topics: Adult; Androstanols; Anesthesia, General; Dose-Response Relationship, Drug; Double-Blind Method; Fem

2015
Effect of different anesthetic agents on oculocardiac reflex in pediatric strabismus surgery.
    Journal of anesthesia, 2009, Volume: 23, Issue:4

    Topics: Androstanols; Anesthesia; Anesthesia, General; Anesthetics; Anesthetics, Dissociative; Anesthetics,

2009
The effect of ketamine on tracheal intubating conditions without neuromuscular blockade during sevoflurane induction in children.
    Journal of anesthesia, 2011, Volume: 25, Issue:2

    Topics: Anesthetics, Inhalation; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Humans; Intuba

2011
Thiopental-rocuronium versus ketamine-rocuronium for rapid-sequence intubation in parturients undergoing cesarean section.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Adult; Androstanols; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Cesarea

1997

Other Studies

5 other studies available for ketamine and Neuromuscular Blockade

ArticleYear
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2015, Volume: 16, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Critical Illness; Female; Fentanyl; Hemodynamics; Humans; Hypno

2015
Pharmacologic recipes for tracheal intubation in the PICU: what's on the menu?
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2015, Volume: 16, Issue:3

    Topics: Critical Illness; Female; Fentanyl; Humans; Intubation, Intratracheal; Ketamine; Male; Midazolam; Ne

2015
Bispectral index monitoring (BIS) as a guide for intubation without neuromuscular blockade in office-based pediatric general anesthesia: a retrospective evaluation.
    Anesthesia progress, 2011,Spring, Volume: 58, Issue:1

    Topics: Administration, Oral; Adolescent; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthet

2011
[Case of Rett syndrome monitored with BIS and neuromuscular monitor during total intravenous anesthesia].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:6

    Topics: Adenoviridae; Androstanols; Anesthesia, Intravenous; Child; Consciousness Monitors; Female; Humans;

2011
SI neuron response variability is stimulus tuned and NMDA receptor dependent.
    Journal of neurophysiology, 1999, Volume: 81, Issue:6

    Topics: Action Potentials; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Functio

1999