Page last updated: 2024-10-29

ketamine and Hypercapnia

ketamine has been researched along with Hypercapnia in 9 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
"Although it has been reported that ketamine attenuates hypercapnia-induced cerebral vasodilation, the mechanism remains unknown."7.71L-arginine and nitroglycerin restore hypercapnia-induced cerebral vasodilation in rabbits after its attenuation by ketamine. ( Dohi, S; Iida, H; Nagase, K, 2002)
"The purpose of this study is to investigate the hypothesis that ketamine, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, attenuates hypoxia-induced striatal dopamine release in vivo."7.69Ketamine antagonizes hypoxia-induced dopamine release in rat striatum. ( Chiou, AL; Lin, JC; Wang, Y; Yang, ST, 1995)
"The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased."7.65Response to hypercapnia under ketamine anaesthesia. ( Brindle, GF; Kuster, G; Soliman, MG, 1975)
"The purpose of this study was to determine the cumulative effects of brief intervals of hypoxia and hypercapnia on the pulsatile characteristics of the pulmonary arterial circulation of 48-h-old compared with 2-wk-old open-chest Yorkshire pigs while using two different anesthetic regimens: 1) azaperone and ketamine (4 and 12 mg/kg im, respectively) and 2) thiopental sodium (25 mg/kg i."3.69Pulmonary hydraulic impedance responses to hypoxia and hypercapnia in newborn pigs. ( Analouei, AR; Cockerham, JT; Crescenzo, DG; Domkowski, PW; Dyer, KL; Hopkins, RA; Kot, PA; Messier, RH; Wallace, RB; Wang, Y, 1994)
"The purpose of this study is to investigate the hypothesis that ketamine, a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, attenuates hypoxia-induced striatal dopamine release in vivo."3.69Ketamine antagonizes hypoxia-induced dopamine release in rat striatum. ( Chiou, AL; Lin, JC; Wang, Y; Yang, ST, 1995)
"The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased."3.65Response to hypercapnia under ketamine anaesthesia. ( Brindle, GF; Kuster, G; Soliman, MG, 1975)
"The ventilatory responses to isocapnic hypoxia and hypercapnia were studied in seven chronically tracheostomized dogs awake and during anesthesia with pentobarbital (30 mg/kg, iv), ketamine, or thiopental (10 and 15 mg/kg, respectively, followed by infusion)."3.65Hypoxic ventilatory drive in dogs during thiopental, ketamine, or pentobarbital anesthesia. ( Cohen, PJ; Hirshman, CA; McCullough, RE; Weil, JV, 1975)
"Metabolic alkalosis was induced acutely following ketamine/xylazine injection."1.31Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis. ( Rapoport, RM; Yoon, SH; Zuccarello, M, 2000)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Svorc, P2
Petrášová, D1
Wey, HY1
Wang, DJ1
Duong, TQ1
Domkowski, PW1
Cockerham, JT1
Crescenzo, DG1
Kot, PA1
Dyer, KL1
Wang, Y2
Messier, RH1
Analouei, AR1
Wallace, RB1
Hopkins, RA1
Chiou, AL1
Yang, ST1
Lin, JC1
Nagase, K1
Iida, H1
Dohi, S1
Yoon, SH1
Zuccarello, M1
Rapoport, RM1
Sedgwick, CJ1
Soliman, MG1
Brindle, GF1
Kuster, G1
Hirshman, CA1
McCullough, RE1
Cohen, PJ1
Weil, JV1

Other Studies

9 other studies available for ketamine and Hypercapnia

ArticleYear
Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study.
    Physiological research, 2018, 11-14, Volume: 67, Issue:5

    Topics: Anesthesia, General; Anesthetics, General; Animals; Blood Gas Analysis; Chronobiology Phenomena; Dru

2018
Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011, Volume: 31, Issue:2

    Topics: Algorithms; Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Brain; Calibrat

2011
Pulmonary hydraulic impedance responses to hypoxia and hypercapnia in newborn pigs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 77, Issue:1

    Topics: Airway Resistance; Animals; Animals, Newborn; Azaperone; Blood Gas Analysis; Energy Metabolism; Fema

1994
Ketamine antagonizes hypoxia-induced dopamine release in rat striatum.
    Brain research, 1995, Sep-25, Volume: 693, Issue:1-2

    Topics: Animals; Blood Gas Analysis; Dopamine; Dopamine Antagonists; Electrochemistry; Hydrogen-Ion Concentr

1995
L-arginine and nitroglycerin restore hypercapnia-induced cerebral vasodilation in rabbits after its attenuation by ketamine.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:4

    Topics: Animals; Arginine; Carbon Dioxide; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; H

2002
Reversal of hypercapnia induces KATP channel and NO-independent constriction of basilar artery in rabbits with acute metabolic alkalosis.
    General pharmacology, 2000, Volume: 35, Issue:6

    Topics: Adrenergic alpha-Agonists; Alkalosis; Animals; ATP-Binding Cassette Transporters; Basilar Artery; Bl

2000
Field anesthesia in stressed animals.
    Modern veterinary practice, 1979, Volume: 60, Issue:7

    Topics: Acepromazine; Acidosis; Anesthesia; Animals; Animals, Zoo; Artiodactyla; Diazepam; Etorphine; Fever;

1979
Response to hypercapnia under ketamine anaesthesia.
    Canadian Anaesthetists' Society journal, 1975, Volume: 22, Issue:4

    Topics: Acid-Base Equilibrium; Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Carbon Dioxide; C

1975
Hypoxic ventilatory drive in dogs during thiopental, ketamine, or pentobarbital anesthesia.
    Anesthesiology, 1975, Volume: 43, Issue:6

    Topics: Anesthesia, Intravenous; Animals; Carbon Dioxide; Dogs; Female; Hypercapnia; Hypoxia; Ketamine; Male

1975