Page last updated: 2024-10-29

ketamine and Syndrome

ketamine has been researched along with Syndrome in 25 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."9.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
"Ketamine has played a versatile role in medicine due to its wide spectrum of uses in history including use in sedation, catalepsy, somatic analgesia, bronchodilation, and recent trial in complex chronic pain syndromes."8.02Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report. ( Angstadt, R; Esperti, S; Mangano, A; Meyer, S, 2021)
"Ketamine's application in psychiatry have expanded, but it appears never to have been previously used to diagnose and treat patients with catatonia-like syndrome that occasionally present to emergency departments."7.96Catatonia-Like Syndrome Treated With Low-Dose Ketamine. ( Durga, D; Iserson, KV, 2020)
"A syndrome of cystitis and contracted bladder can be associated with street-ketamine abuse."7.74The destruction of the lower urinary tract by ketamine abuse: a new syndrome? ( Cheng, CH; Chu, PS; Chu, RW; Lau, FL; Ma, WK; Man, CW; Tse, JM; Wong, S; Wong, SC; Yiu, MK, 2008)
"We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain."7.69Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995)
"Ketamine is an NMDA-blocking agent widely used in human medicine."6.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"Ketamine has become increasingly recognized as a drug of recreational use."6.47Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011)
"Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States."5.46Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. ( Gordon, L; Kivovich, V; Wang, JW, 2017)
"Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties."5.31Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002)
"A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain."5.11Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005)
"In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests."5.08Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy. ( Hirayama, T; Katayama, Y; Tsubokawa, T; Yamamoto, T, 1997)
"Ketamine has played a versatile role in medicine due to its wide spectrum of uses in history including use in sedation, catalepsy, somatic analgesia, bronchodilation, and recent trial in complex chronic pain syndromes."4.02Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report. ( Angstadt, R; Esperti, S; Mangano, A; Meyer, S, 2021)
"Ketamine's application in psychiatry have expanded, but it appears never to have been previously used to diagnose and treat patients with catatonia-like syndrome that occasionally present to emergency departments."3.96Catatonia-Like Syndrome Treated With Low-Dose Ketamine. ( Durga, D; Iserson, KV, 2020)
" In the first operation, in which anesthesia induction was applied with ketamine and midazolam, extremity movements with surgical stimuli were seen."3.85Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case. ( Arslan, M; Balaban, A; Duman, Y; Gisi, G; Oksuz, G; Oksuz, H; Urfalioglu, A; Yildiz, H, 2017)
"A syndrome of cystitis and contracted bladder can be associated with street-ketamine abuse."3.74The destruction of the lower urinary tract by ketamine abuse: a new syndrome? ( Cheng, CH; Chu, PS; Chu, RW; Lau, FL; Ma, WK; Man, CW; Tse, JM; Wong, S; Wong, SC; Yiu, MK, 2008)
"We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain."3.69Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995)
"Ketamine and fentanyl were used for surgery of esophageal hiatus hernia in a 9 month old boy with single ventricle (asplenia syndrome)."3.68[Anesthetic management of an infant with a single ventricle (asplenia syndrome) for non-cardiac surgery]. ( Ando, T; Okuda, C; Uchida, K, 1992)
"Ketamine is an NMDA-blocking agent widely used in human medicine."2.67Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994)
"Ketamine has become increasingly recognized as a drug of recreational use."2.47Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011)
"We review PPS, cardiac tamponade, and the proper performance of a pericardiocentesis."2.42Cardiac tamponade complicating postpericardiotomy syndrome. ( Alessandrini, EA; Donoghue, AJ; Scarfone, RJ, 2003)
"Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States."1.46Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. ( Gordon, L; Kivovich, V; Wang, JW, 2017)
"Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties."1.31Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002)
"Watson's syndrome is an uncommon genetic disorder whose features include mental retardation and pulmonary valvular stenosis."1.29Anaesthesia for caesarean section in a patient with Watson's syndrome. ( Conway, JB; Posner, M, 1994)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's8 (32.00)18.2507
2000's8 (32.00)29.6817
2010's6 (24.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Iserson, KV1
Durga, D1
Angstadt, R1
Esperti, S1
Mangano, A1
Meyer, S1
Gonin, P1
Beysard, N1
Yersin, B1
Carron, PN1
Urfalioglu, A1
Arslan, M1
Duman, Y1
Gisi, G1
Oksuz, G1
Yildiz, H1
Oksuz, H1
Balaban, A1
De Monte, V1
Staffieri, F1
Birettoni, F1
Bufalari, A1
Wang, JW1
Kivovich, V1
Gordon, L1
Chu, PS1
Ma, WK1
Wong, SC1
Chu, RW1
Cheng, CH1
Wong, S1
Tse, JM1
Lau, FL1
Yiu, MK1
Man, CW1
Pavlov, OO1
Cottrell, A2
Warren, K1
Ayres, R1
Weinstock, P1
Kumar, V1
Gillatt, D2
Wood, D1
Baker, SC1
Southgate, J1
Harris, M1
Fulford, S1
Woodhouse, C1
Chandrakantan, A1
Poulton, TJ1
Scarfone, RJ1
Donoghue, AJ1
Alessandrini, EA1
Yegin, A1
Sanli, S1
Hadimioglu, N1
Sahin, N1
Lynch, ME1
Clark, AJ1
Sawynok, J1
Sullivan, MJ1
Spiller, J1
Burrows, FA1
Seeman, RG1
Mathisen, LC1
Skjelbred, P1
Skoglund, LA1
Øye, I1
Conway, JB1
Posner, M1
Backonja, M1
Arndt, G1
Gombar, KA1
Check, B1
Zimmermann, M1
Raidal, SR1
Raidal, SL1
Richards, RB1
Cosgriff, AV1
Rose, KJ1
Yamamoto, T1
Katayama, Y1
Hirayama, T1
Tsubokawa, T1
Fitzgibbon, EJ1
Hall, P1
Schroder, C1
Seely, J1
Viola, R1
Uchida, K1
Ando, T1
Okuda, C1
Stevenson, GW1
Hall, SC1
Palmieri, J1
Reed, AP1
Tausk, H1
Reynolds, H1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915]314 participants (Actual)Observational2017-08-01Completed
Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis[NCT04821882]29 participants (Actual)Interventional2019-05-01Completed
Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction[NCT03913819]1,000 participants (Anticipated)Observational2011-12-10Recruiting
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444]Phase 213 participants (Actual)Interventional2017-05-23Terminated (stopped due to Efficacy was not seen after interim analysis)
Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904]15 participants (Anticipated)Observational2011-06-30Recruiting
Naloxone Block of Low-dose (Analgetic Dose) Ketamine[NCT00921765]Phase 43 participants (Actual)Interventional2009-12-31Terminated (stopped due to Problems with patient recruitment)
Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325]Phase 324 participants (Actual)Interventional2011-07-31Completed
Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417]Phase 2120 participants (Anticipated)Interventional2022-05-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Peak Itch Intensity Between the Vehicle and Active Treatments (Individual and KeAmLi-combo).

"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes

InterventionIntensity score (Mean)
Topical KeAmLi Combo62.7
Topical Ketamine63.1
Topical Amitriptyline69.2
Topical Lidocaine65.8
Topical Vehicle61.9

Mechanical Thresholds (Mechanical Detection and Pain).

Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes

,,,,
InterventionmN (Mean)
Mechanical Detection ThresholdMechanical Pain Threshold
Topical Amitriptyline3.573423965152.4768146
Topical KeAmLi Combo3.519376956152.3293608
Topical Ketamine3.464204768135.9
Topical Lidocaine3.546037659126.9
Topical Vehicle3.525692637148.7138273

Thermal Threshold Detection (Warmth and Heat Pain)

Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes

,,,,
InterventionDegrees celsius (Mean)
Warm Detection ThresholdHeat Pain Threshold
Topical Amitriptyline33.940.0
Topical KeAmLi Combo33.639.8
Topical Ketamine34.040.0
Topical Lidocaine33.739.4
Topical Vehicle33.839.7

Reviews

3 reviews available for ketamine and Syndrome

ArticleYear
Excited Delirium: A Systematic Review.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2018, Volume: 25, Issue:5

    Topics: Antipsychotic Agents; Delirium; Female; Humans; Ketamine; Male; Psychomotor Agitation; Retrospective

2018
Recreational ketamine: from pleasure to pain.
    BJU international, 2011, Volume: 107, Issue:12

    Topics: Adolescent; Adult; Analgesics; Epidemiologic Methods; Humans; Illicit Drugs; Ketamine; Middle Aged;

2011
Cardiac tamponade complicating postpericardiotomy syndrome.
    Pediatric emergency care, 2003, Volume: 19, Issue:4

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Cardiac Tamponade; Child; Child, Preschool; Combined

2003

Trials

4 trials available for ketamine and Syndrome

ArticleYear
[The tissue oxygen cascade as the marker in different schemes of general anesthesia on dynamics of the hypoxic syndrome in patients, suffering an acute hemorrhage of high operative risk].
    Klinichna khirurhiia, 2008, Issue:6

    Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Female; Fen

2008
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
    Anesthesiology, 2005, Volume: 103, Issue:1

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th

2005
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
    Pain, 1994, Volume: 56, Issue:1

    Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans;

1994
Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy.
    Pain, 1997, Volume: 72, Issue:1-2

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics; Cerebrovascular Disorders; Female; Humans; Ketamine; L

1997

Other Studies

18 other studies available for ketamine and Syndrome

ArticleYear
Catatonia-Like Syndrome Treated With Low-Dose Ketamine.
    The Journal of emergency medicine, 2020, Volume: 58, Issue:5

    Topics: Adult; Catatonia; Excitatory Amino Acid Antagonists; Humans; Ketamine; Male; Syndrome; Young Adult

2020
Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report.
    Annals of palliative medicine, 2021, Volume: 10, Issue:6

    Topics: Adult; Female; Humans; Ketamine; Neuralgia; Quality of Life; Stroke; Syndrome

2021
Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2017, Volume: 84, Issue:5

    Topics: Anesthesia; Body Temperature; Calcaneus; Child; Consciousness Monitors; Foot Ulcer; Hereditary Senso

2017
Ketamine as a part of anaesthetic management in a dog with twiddler's syndrome.
    The Journal of small animal practice, 2014, Volume: 55, Issue:2

    Topics: Anesthesia, General; Anesthetics, Dissociative; Animals; Atrioventricular Block; Dog Diseases; Dogs;

2014
Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.
    Pediatric emergency care, 2017, Volume: 33, Issue:8

    Topics: Abdominal Pain; Adolescent; Adult; Anesthetics, Dissociative; Asian; Delayed Diagnosis; Emigrants an

2017
The destruction of the lower urinary tract by ketamine abuse: a new syndrome?
    BJU international, 2008, Volume: 102, Issue:11

    Topics: Adolescent; Adult; Cystoscopy; Female; Humans; Ketamine; Male; Retrospective Studies; Substance-Rela

2008
The destruction of the lower urinary tract by ketamine abuse: a new syndrome?
    BJU international, 2008, Volume: 102, Issue:9

    Topics: Humans; Ketamine; Substance-Related Disorders; Syndrome; Urinary Tract

2008
Anesthetic considerations for rapid-onset obesity, hypoventilation, hypothalamic dysfunction, and autonomic dysfunction (ROHHAD) syndrome in children.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:1

    Topics: Adjuvants, Anesthesia; Analgesics; Androstanols; Anesthesia, General; Anesthetics, Inhalation; Atrop

2013
Anesthesia in caudal regression syndrome.
    Paediatric anaesthesia, 2005, Volume: 15, Issue:2

    Topics: Abnormalities, Multiple; Analgesics; Analgesics, Opioid; Anesthesia, General; Fentanyl; Humans; Infa

2005
Acupuncture, ketamine and piriformis syndrome--a case report from palliative care.
    Acupuncture in medicine : journal of the British Medical Acupuncture Society, 2007, Volume: 25, Issue:3

    Topics: Acupuncture Therapy; Amines; Analgesics; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Gab

2007
Ketamine and myoclonic encephalopathy of infants (Kinsbourne syndrome).
    Anesthesia and analgesia, 1982, Volume: 61, Issue:10

    Topics: Anesthesia; Brain Diseases; Humans; Infant; Infant, Newborn; Ketamine; Male; Myoclonus; Syndrome; Th

1982
Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain.
    Pain, 1995, Volume: 61, Issue:2

    Topics: Acute Disease; Adult; Aged; Chronic Disease; Facial Pain; Female; Follow-Up Studies; Humans; Inciden

1995
Anaesthesia for caesarean section in a patient with Watson's syndrome.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:11

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; B

1994
Acute paraplegia in a thoroughbred racehorse after general anaesthesia.
    Australian veterinary journal, 1997, Volume: 75, Issue:3

    Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, General; Animals; Hemorr

1997
Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:2

    Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Humans; Infusions, Parenteral; Ketamine;

2002
[Anesthetic management of an infant with a single ventricle (asplenia syndrome) for non-cardiac surgery].
    Masui. The Japanese journal of anesthesiology, 1992, Volume: 41, Issue:11

    Topics: Anesthesia, General; Fentanyl; Heart Ventricles; Hernia, Hiatal; Humans; Infant; Ketamine; Male; Spl

1992
Anesthetic considerations for patients with Larsen's syndrome.
    Anesthesiology, 1991, Volume: 75, Issue:1

    Topics: Anesthesia, Inhalation; Atropine; Bone and Bones; Connective Tissue Diseases; Female; Halothane; Hum

1991
Anesthetic considerations for severe ovarian hyperstimulation syndrome.
    Anesthesiology, 1990, Volume: 73, Issue:6

    Topics: Abortion, Therapeutic; Adult; Anesthesia, General; Anesthesia, Obstetrical; Female; Humans; Ketamine

1990