ketamine has been researched along with Syndrome in 25 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 9.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "Ketamine has played a versatile role in medicine due to its wide spectrum of uses in history including use in sedation, catalepsy, somatic analgesia, bronchodilation, and recent trial in complex chronic pain syndromes." | 8.02 | Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report. ( Angstadt, R; Esperti, S; Mangano, A; Meyer, S, 2021) |
| "Ketamine's application in psychiatry have expanded, but it appears never to have been previously used to diagnose and treat patients with catatonia-like syndrome that occasionally present to emergency departments." | 7.96 | Catatonia-Like Syndrome Treated With Low-Dose Ketamine. ( Durga, D; Iserson, KV, 2020) |
| "A syndrome of cystitis and contracted bladder can be associated with street-ketamine abuse." | 7.74 | The destruction of the lower urinary tract by ketamine abuse: a new syndrome? ( Cheng, CH; Chu, PS; Chu, RW; Lau, FL; Ma, WK; Man, CW; Tse, JM; Wong, S; Wong, SC; Yiu, MK, 2008) |
| "We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain." | 7.69 | Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995) |
| "Ketamine is an NMDA-blocking agent widely used in human medicine." | 6.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
| "Ketamine has become increasingly recognized as a drug of recreational use." | 6.47 | Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011) |
| "Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States." | 5.46 | Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. ( Gordon, L; Kivovich, V; Wang, JW, 2017) |
| "Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties." | 5.31 | Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002) |
| "A double-blind, randomized, placebo-controlled 3-week study evaluated the efficacy of topical 2% amitriptyline, 1% ketamine, and a combination of both in treating patients with neuropathic pain." | 5.11 | Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. ( Clark, AJ; Lynch, ME; Sawynok, J; Sullivan, MJ, 2005) |
| "In an attempt to clarify the neurochemical background of central post-stroke pain and to undertake a pharmacological analysis, the basic pharmacological characteristics of this intractable pain syndrome were investigated by the morphine, thiamylal and ketamine tests." | 5.08 | Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy. ( Hirayama, T; Katayama, Y; Tsubokawa, T; Yamamoto, T, 1997) |
| "Ketamine has played a versatile role in medicine due to its wide spectrum of uses in history including use in sedation, catalepsy, somatic analgesia, bronchodilation, and recent trial in complex chronic pain syndromes." | 4.02 | Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report. ( Angstadt, R; Esperti, S; Mangano, A; Meyer, S, 2021) |
| "Ketamine's application in psychiatry have expanded, but it appears never to have been previously used to diagnose and treat patients with catatonia-like syndrome that occasionally present to emergency departments." | 3.96 | Catatonia-Like Syndrome Treated With Low-Dose Ketamine. ( Durga, D; Iserson, KV, 2020) |
| " In the first operation, in which anesthesia induction was applied with ketamine and midazolam, extremity movements with surgical stimuli were seen." | 3.85 | Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case. ( Arslan, M; Balaban, A; Duman, Y; Gisi, G; Oksuz, G; Oksuz, H; Urfalioglu, A; Yildiz, H, 2017) |
| "A syndrome of cystitis and contracted bladder can be associated with street-ketamine abuse." | 3.74 | The destruction of the lower urinary tract by ketamine abuse: a new syndrome? ( Cheng, CH; Chu, PS; Chu, RW; Lau, FL; Ma, WK; Man, CW; Tse, JM; Wong, S; Wong, SC; Yiu, MK, 2008) |
| "We examined the analgesic effect of racemic ketamine and its 2 enantiomers in 16 female patients (age: 20-29 years) suffering acute pain after oral surgery and in 7 female patients (age: 42-79 years) suffering chronic neuropathic orofacial pain." | 3.69 | Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain. ( Mathisen, LC; Skjelbred, P; Skoglund, LA; Øye, I, 1995) |
| "Ketamine and fentanyl were used for surgery of esophageal hiatus hernia in a 9 month old boy with single ventricle (asplenia syndrome)." | 3.68 | [Anesthetic management of an infant with a single ventricle (asplenia syndrome) for non-cardiac surgery]. ( Ando, T; Okuda, C; Uchida, K, 1992) |
| "Ketamine is an NMDA-blocking agent widely used in human medicine." | 2.67 | Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. ( Arndt, G; Backonja, M; Check, B; Gombar, KA; Zimmermann, M, 1994) |
| "Ketamine has become increasingly recognized as a drug of recreational use." | 2.47 | Recreational ketamine: from pleasure to pain. ( Baker, SC; Cottrell, A; Fulford, S; Gillatt, D; Harris, M; Southgate, J; Wood, D; Woodhouse, C, 2011) |
| "We review PPS, cardiac tamponade, and the proper performance of a pericardiocentesis." | 2.42 | Cardiac tamponade complicating postpericardiotomy syndrome. ( Alessandrini, EA; Donoghue, AJ; Scarfone, RJ, 2003) |
| "Ketamine is a recreational drug widely abused in East Asia and also in certain subpopulations of the United States." | 1.46 | Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY. ( Gordon, L; Kivovich, V; Wang, JW, 2017) |
| "Ketamine is a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist with analgesic and dissociative anesthetic properties." | 1.31 | Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine. ( Fitzgibbon, EJ; Hall, P; Schroder, C; Seely, J; Viola, R, 2002) |
| "Watson's syndrome is an uncommon genetic disorder whose features include mental retardation and pulmonary valvular stenosis." | 1.29 | Anaesthesia for caesarean section in a patient with Watson's syndrome. ( Conway, JB; Posner, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iserson, KV | 1 |
| Durga, D | 1 |
| Angstadt, R | 1 |
| Esperti, S | 1 |
| Mangano, A | 1 |
| Meyer, S | 1 |
| Gonin, P | 1 |
| Beysard, N | 1 |
| Yersin, B | 1 |
| Carron, PN | 1 |
| Urfalioglu, A | 1 |
| Arslan, M | 1 |
| Duman, Y | 1 |
| Gisi, G | 1 |
| Oksuz, G | 1 |
| Yildiz, H | 1 |
| Oksuz, H | 1 |
| Balaban, A | 1 |
| De Monte, V | 1 |
| Staffieri, F | 1 |
| Birettoni, F | 1 |
| Bufalari, A | 1 |
| Wang, JW | 1 |
| Kivovich, V | 1 |
| Gordon, L | 1 |
| Chu, PS | 1 |
| Ma, WK | 1 |
| Wong, SC | 1 |
| Chu, RW | 1 |
| Cheng, CH | 1 |
| Wong, S | 1 |
| Tse, JM | 1 |
| Lau, FL | 1 |
| Yiu, MK | 1 |
| Man, CW | 1 |
| Pavlov, OO | 1 |
| Cottrell, A | 2 |
| Warren, K | 1 |
| Ayres, R | 1 |
| Weinstock, P | 1 |
| Kumar, V | 1 |
| Gillatt, D | 2 |
| Wood, D | 1 |
| Baker, SC | 1 |
| Southgate, J | 1 |
| Harris, M | 1 |
| Fulford, S | 1 |
| Woodhouse, C | 1 |
| Chandrakantan, A | 1 |
| Poulton, TJ | 1 |
| Scarfone, RJ | 1 |
| Donoghue, AJ | 1 |
| Alessandrini, EA | 1 |
| Yegin, A | 1 |
| Sanli, S | 1 |
| Hadimioglu, N | 1 |
| Sahin, N | 1 |
| Lynch, ME | 1 |
| Clark, AJ | 1 |
| Sawynok, J | 1 |
| Sullivan, MJ | 1 |
| Spiller, J | 1 |
| Burrows, FA | 1 |
| Seeman, RG | 1 |
| Mathisen, LC | 1 |
| Skjelbred, P | 1 |
| Skoglund, LA | 1 |
| Øye, I | 1 |
| Conway, JB | 1 |
| Posner, M | 1 |
| Backonja, M | 1 |
| Arndt, G | 1 |
| Gombar, KA | 1 |
| Check, B | 1 |
| Zimmermann, M | 1 |
| Raidal, SR | 1 |
| Raidal, SL | 1 |
| Richards, RB | 1 |
| Cosgriff, AV | 1 |
| Rose, KJ | 1 |
| Yamamoto, T | 1 |
| Katayama, Y | 1 |
| Hirayama, T | 1 |
| Tsubokawa, T | 1 |
| Fitzgibbon, EJ | 1 |
| Hall, P | 1 |
| Schroder, C | 1 |
| Seely, J | 1 |
| Viola, R | 1 |
| Uchida, K | 1 |
| Ando, T | 1 |
| Okuda, C | 1 |
| Stevenson, GW | 1 |
| Hall, SC | 1 |
| Palmieri, J | 1 |
| Reed, AP | 1 |
| Tausk, H | 1 |
| Reynolds, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ketamine Versus Midazolam for Prehospital Agitation[NCT03554915] | 314 participants (Actual) | Observational | 2017-08-01 | Completed | |||
| Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis[NCT04821882] | 29 participants (Actual) | Interventional | 2019-05-01 | Completed | |||
| Prospective Longitudinal Study on the Treatment Outcomes of Various Treatment Modalities Under a Standardized Treatment Protocol in Patients Suffered Substance Abuse Related Voiding Dysfunction[NCT03913819] | 1,000 participants (Anticipated) | Observational | 2011-12-10 | Recruiting | |||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Plasma Concentrations of Ketamine and Norketamine in Patients Using Topical Application of 10% Ketamine for Neuropathic Pain.[NCT01385904] | 15 participants (Anticipated) | Observational | 2011-06-30 | Recruiting | |||
| Naloxone Block of Low-dose (Analgetic Dose) Ketamine[NCT00921765] | Phase 4 | 3 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Problems with patient recruitment) | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Conscious Dying/Conscious Living: Ketamine-Assisted Psychotherapy (KAP) for Patients at End of Life-A Pilot Study for Palliative and Hospice Care[NCT05214417] | Phase 2 | 120 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
3 reviews available for ketamine and Syndrome
| Article | Year |
|---|---|
Excited Delirium: A Systematic Review.
Topics: Antipsychotic Agents; Delirium; Female; Humans; Ketamine; Male; Psychomotor Agitation; Retrospective | 2018 |
Recreational ketamine: from pleasure to pain.
Topics: Adolescent; Adult; Analgesics; Epidemiologic Methods; Humans; Illicit Drugs; Ketamine; Middle Aged; | 2011 |
Cardiac tamponade complicating postpericardiotomy syndrome.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Cardiac Tamponade; Child; Child, Preschool; Combined | 2003 |
4 trials available for ketamine and Syndrome
| Article | Year |
|---|---|
[The tissue oxygen cascade as the marker in different schemes of general anesthesia on dynamics of the hypoxic syndrome in patients, suffering an acute hemorrhage of high operative risk].
Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Female; Fen | 2008 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Amitriptyline; Double-Blind Method; Drug Th | 2005 |
Response of chronic neuropathic pain syndromes to ketamine: a preliminary study.
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; | 1994 |
Pharmacological classification of central post-stroke pain: comparison with the results of chronic motor cortex stimulation therapy.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics; Cerebrovascular Disorders; Female; Humans; Ketamine; L | 1997 |
18 other studies available for ketamine and Syndrome
| Article | Year |
|---|---|
Catatonia-Like Syndrome Treated With Low-Dose Ketamine.
Topics: Adult; Catatonia; Excitatory Amino Acid Antagonists; Humans; Ketamine; Male; Syndrome; Young Adult | 2020 |
Palliative ketamine: the use of ketamine in central post-stroke pain syndrome-a case report.
Topics: Adult; Female; Humans; Ketamine; Neuralgia; Quality of Life; Stroke; Syndrome | 2021 |
Anesthesia Procedure for Congenital Insensitivity to Pain in a Child with Anhidrosis Syndrome: A Rare Case.
Topics: Anesthesia; Body Temperature; Calcaneus; Child; Consciousness Monitors; Foot Ulcer; Hereditary Senso | 2017 |
Ketamine as a part of anaesthetic management in a dog with twiddler's syndrome.
Topics: Anesthesia, General; Anesthetics, Dissociative; Animals; Atrioventricular Block; Dog Diseases; Dogs; | 2014 |
Ketamine Abuse Syndrome: Hepatobiliary and Urinary Pathology Among Adolescents in Flushing, NY.
Topics: Abdominal Pain; Adolescent; Adult; Anesthetics, Dissociative; Asian; Delayed Diagnosis; Emigrants an | 2017 |
The destruction of the lower urinary tract by ketamine abuse: a new syndrome?
Topics: Adolescent; Adult; Cystoscopy; Female; Humans; Ketamine; Male; Retrospective Studies; Substance-Rela | 2008 |
The destruction of the lower urinary tract by ketamine abuse: a new syndrome?
Topics: Humans; Ketamine; Substance-Related Disorders; Syndrome; Urinary Tract | 2008 |
Anesthetic considerations for rapid-onset obesity, hypoventilation, hypothalamic dysfunction, and autonomic dysfunction (ROHHAD) syndrome in children.
Topics: Adjuvants, Anesthesia; Analgesics; Androstanols; Anesthesia, General; Anesthetics, Inhalation; Atrop | 2013 |
Anesthesia in caudal regression syndrome.
Topics: Abnormalities, Multiple; Analgesics; Analgesics, Opioid; Anesthesia, General; Fentanyl; Humans; Infa | 2005 |
Acupuncture, ketamine and piriformis syndrome--a case report from palliative care.
Topics: Acupuncture Therapy; Amines; Analgesics; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Gab | 2007 |
Ketamine and myoclonic encephalopathy of infants (Kinsbourne syndrome).
Topics: Anesthesia; Brain Diseases; Humans; Infant; Infant, Newborn; Ketamine; Male; Myoclonus; Syndrome; Th | 1982 |
Effect of ketamine, an NMDA receptor inhibitor, in acute and chronic orofacial pain.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Facial Pain; Female; Follow-Up Studies; Humans; Inciden | 1995 |
Anaesthesia for caesarean section in a patient with Watson's syndrome.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthesia, Obstetrical; B | 1994 |
Acute paraplegia in a thoroughbred racehorse after general anaesthesia.
Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, General; Animals; Hemorr | 1997 |
Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine.
Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Humans; Infusions, Parenteral; Ketamine; | 2002 |
[Anesthetic management of an infant with a single ventricle (asplenia syndrome) for non-cardiac surgery].
Topics: Anesthesia, General; Fentanyl; Heart Ventricles; Hernia, Hiatal; Humans; Infant; Ketamine; Male; Spl | 1992 |
Anesthetic considerations for patients with Larsen's syndrome.
Topics: Anesthesia, Inhalation; Atropine; Bone and Bones; Connective Tissue Diseases; Female; Halothane; Hum | 1991 |
Anesthetic considerations for severe ovarian hyperstimulation syndrome.
Topics: Abortion, Therapeutic; Adult; Anesthesia, General; Anesthesia, Obstetrical; Female; Humans; Ketamine | 1990 |