ketamine has been researched along with Respiration Disorders in 13 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Respiration Disorders: Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.
Excerpt | Relevance | Reference |
---|---|---|
"4%: airway malalignment (n = 7), laryngospasm (n = 4), apnea (n = 2), and respiratory depression (n = 1)." | 3.70 | Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases. ( Garrett, W; Green, SM; Harris, T; Hestdalen, R; Ho, M; Hopkins, GA; Lynch, EL; Rothrock, SG; Westcott, K, 1998) |
"Morphine consumption was evaluated by cumulative doses every 12 h for the three postoperative days." | 2.73 | Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. ( Avaro, JP; Blayac, D; Dantin, T; Gaillat, F; Guervilly, C; Hélaine, A; Kerbaul, F; Michelet, P; Thomas, P, 2007) |
" It also reviews the comparative pharmacokinetics, adverse effects, and dosing of ketamine, propofol, and ketofol as agents for procedural sedation and analgesia." | 2.48 | Ketamine, propofol, and ketofol use for pediatric sedation. ( Alletag, MJ; Auerbach, MA; Baum, CR, 2012) |
" The aim of our study is to assess the incidence of respiratory adverse events during upper digestive endoscopies in children under Ketamine sedation when performed without oxygen supplementation, in accordance with the latest recommendations." | 1.62 | Respiratory adverse events during upper digestive endoscopies in children under ketamine sedation. ( Blanca García, JA; Cruzado García, MD; Flores-González, JC; Jimenez Gomez, G; Lechuga-Sancho, AM; Pérez Aragón, C; Saldaña Valderas, M, 2021) |
"Upper gastrointestinal endoscopies (UGEs) performed under ketamine sedation may increase the risk of respiratory adverse events (RAEs) due to pharyngeal stimulation." | 1.51 | Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children. ( Estalella-Mendoza, A; Flores-González, JC; Lechuga-Sancho, AM; Rodríguez-Campoy, P; Saldaña-Valderas, M, 2019) |
"Compare the frequency of respiratory adverse events between patients who received intramuscular (IM) versus intravenous ketamine." | 1.35 | Serious adverse events during procedural sedation with ketamine. ( Bachur, R; Melendez, E, 2009) |
"Ketamine infusion was the technique most frequently used." | 1.28 | Anaesthetic experience with paediatric interventional cardiology. ( Benson, LN; Burrows, FA; Johnston, AE; Malviya, S, 1989) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (15.38) | 18.7374 |
1990's | 2 (15.38) | 18.2507 |
2000's | 3 (23.08) | 29.6817 |
2010's | 5 (38.46) | 24.3611 |
2020's | 1 (7.69) | 2.80 |
Authors | Studies |
---|---|
Flores-González, JC | 2 |
Estalella-Mendoza, A | 1 |
Rodríguez-Campoy, P | 1 |
Saldaña-Valderas, M | 1 |
Lechuga-Sancho, AM | 2 |
Sullivan, RW | 1 |
Ryzewski, M | 1 |
Holland, MG | 1 |
Marraffa, JM | 1 |
Miner, JR | 1 |
Moore, JC | 1 |
Austad, EJ | 1 |
Plummer, D | 1 |
Hubbard, L | 1 |
Gray, RO | 1 |
Green, SM | 2 |
Andolfatto, G | 1 |
Krauss, BS | 1 |
Saldaña Valderas, M | 1 |
Jimenez Gomez, G | 1 |
Cruzado García, MD | 1 |
Pérez Aragón, C | 1 |
Blanca García, JA | 1 |
Melendez, E | 1 |
Bachur, R | 1 |
Alletag, MJ | 1 |
Auerbach, MA | 1 |
Baum, CR | 1 |
Godambe, SA | 1 |
Elliot, V | 1 |
Matheny, D | 1 |
Pershad, J | 1 |
Michelet, P | 1 |
Guervilly, C | 1 |
Hélaine, A | 1 |
Avaro, JP | 1 |
Blayac, D | 1 |
Gaillat, F | 1 |
Dantin, T | 1 |
Thomas, P | 1 |
Kerbaul, F | 1 |
Gudushauri, ON | 1 |
Tsverava, VG | 1 |
Odilavadze, ZN | 1 |
Dundua, NG | 1 |
Lebanidze, NG | 1 |
Rothrock, SG | 1 |
Lynch, EL | 1 |
Ho, M | 1 |
Harris, T | 1 |
Hestdalen, R | 1 |
Hopkins, GA | 1 |
Garrett, W | 1 |
Westcott, K | 1 |
Greene, CA | 1 |
Gillette, PC | 1 |
Fyfe, DA | 1 |
Malviya, S | 1 |
Burrows, FA | 1 |
Johnston, AE | 1 |
Benson, LN | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
Prospective Observational Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio at the Emergency Department of a Tertiary Hospital[NCT04028141] | 61 participants (Actual) | Observational | 2018-02-01 | Completed | |||
Randomized Blinded Three Arm Trial of Propofol, 1:1 Combination of Propofol and Ketamine, and 4:1 Combination of Propofol and Ketamine for Procedural Sedation in the Emergency Department[NCT01260662] | Phase 4 | 271 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
ED Treatment of Suicidal Patients With Ketamine Infusion[NCT03502551] | Phase 2 | 0 participants (Actual) | Interventional | 2019-04-01 | Withdrawn (stopped due to Trial never received funding.) | ||
Comparison of Two Methods Using Intranasal Lidocaine to Alleviate Discomfort Associated With Administration of Intranasal Midazolam in Children.[NCT03054844] | Phase 2 | 55 participants (Actual) | Interventional | 2017-04-03 | Completed | ||
A Prospective Randomized Double Blind Evaluation of Ketamine/Propofol vs Ketamine Alone for Pediatric Extremity Fracture Reduction[NCT00490997] | Phase 4 | 140 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions[NCT00596050] | Phase 4 | 50 participants (Actual) | Interventional | 2006-08-31 | Completed | ||
Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
PCA Ketamine-Morphine Versus PCA Morphine as Post-Operative Analgesia in Colorectal Surgery.[NCT06010056] | Phase 4 | 60 participants (Actual) | Interventional | 2018-04-05 | Completed | ||
A Prospective, Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis[NCT02651324] | Phase 4 | 50 participants (Anticipated) | Interventional | 2013-05-31 | Active, not recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
Intervention | Intensity score (Mean) |
---|---|
Topical KeAmLi Combo | 62.7 |
Topical Ketamine | 63.1 |
Topical Amitriptyline | 69.2 |
Topical Lidocaine | 65.8 |
Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
Intervention | mN (Mean) | |
---|---|---|
Mechanical Detection Threshold | Mechanical Pain Threshold | |
Topical Amitriptyline | 3.573423965 | 152.4768146 |
Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
Topical Ketamine | 3.464204768 | 135.9 |
Topical Lidocaine | 3.546037659 | 126.9 |
Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
Intervention | Degrees celsius (Mean) | |
---|---|---|
Warm Detection Threshold | Heat Pain Threshold | |
Topical Amitriptyline | 33.9 | 40.0 |
Topical KeAmLi Combo | 33.6 | 39.8 |
Topical Ketamine | 34.0 | 40.0 |
Topical Lidocaine | 33.7 | 39.4 |
Topical Vehicle | 33.8 | 39.7 |
Add/increase in supplemental oxygen, stimulation to induce respiration, airway repositioning, assisted ventilations, endotracheal intubation (NCT01260662)
Timeframe: From start of sedation procedure to end of sedation procedure, up to 24 hours
Intervention | Clinical interventions performed (Number) |
---|---|
Propofol | 41 |
1:1 Propofol/Ketamine | 33 |
4:1 Propofol/Ketamine | 48 |
Pulse oximetry (NCT01260662)
Timeframe: From start of sedation procedure to end of sedation procedure, up to 24 hours
Intervention | Patients which experienced hypoxia (Number) |
---|---|
Propofol | 11 |
1:1 Propofol/Ketamine | 6 |
4:1 Propofol/Ketamine | 18 |
After patients returned to baseline mental status they were asked whether they were able to recall any of the procedure. Question was answered in a yes or no format. (NCT01260662)
Timeframe: Immediately after the end of the procedure, a single time point within 30 minutes of procedures conclusion.
Intervention | percentage report recall of procedure (Number) |
---|---|
Propofol | 6 |
1:1 Propofol/Ketamine | 14 |
4:1 Propofol/Ketamine | 11 |
Continuous capnographic monitoring (NCT01260662)
Timeframe: From start of sedation procedure to end of sedation procedure, up to 24 hours
Intervention | number of respiratory depression events (Number) |
---|---|
Propofol | 15 |
1:1 Propofol/Ketamine | 16 |
4:1 Propofol/Ketamine | 21 |
If my child needed medications to stay calm for a procedure, I would like to use these same medications again. (NCT03054844)
Timeframe: 1 minute
Intervention | Participants (Count of Participants) |
---|---|
PREMED | 10 |
PREMIX | 12 |
Cry duration was measured in seconds and defined as the time from onset of crying following administration of an IN medication until the cessation of crying sounds and/or tears. If a patient did not cry, the cry duration was zero (NCT03054844)
Timeframe: 10 minutes
Intervention | seconds (Mean) |
---|---|
PREMED | 84 |
PREMIX | 73 |
The Faces, Legs, Activity, Cry, Consolability (FLACC) scale is comprised of five criteria (face, legs, activity, cry, consolability), with a possible score of 0 to 2 units on a scale for each criteria and a possible total score of 0 to 10 units on a scale (0 meaning no pain, 10 meaning most pain). (NCT03054844)
Timeframe: 10 minutes
Intervention | Units on a scale (Mean) |
---|---|
PREMED | 6.7 |
PREMIX | 7 |
The Observational Scale of Behavioral Distress-Revised (OSBD-R) is an observational measure of pain and distress shown to have strong validity in children. The scale is an 8-factor, weighted observational scale used to measure distress associated with medical procedures, which has been validated in children and adults aged 1 to 20 years. The total Observational Scale of Behavioral Distress-Revised score is the sum of the scale scores for each phase, with each phase assigned a score from 0 to 23.5 units on a scale (0=no distress, 23.5=maximum distress), based on the frequency and types of behaviors observed during a predetermined number of 15-second intervals during each phase. There were four phases so the range of scores for the total OSBD-R was 0 to 94 units on a scale, with a higher score indicated a greater degree of distress. (NCT03054844)
Timeframe: 10 minutes
Intervention | Units on a scale (Mean) |
---|---|
PREMED | 6.4 |
PREMIX | 7 |
The Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) utilizes six observational factors (cry, facial, verbal, torso, touch, and legs) to evaluate pain in young children and can be used to monitor the effectiveness of interventions for reducing the pain and discomfort of an intervention. This scale rates each behavior numerically, with a score of 4-6 units on a scale representing no pain, and a maximum score of 13 units on a scale representing (most pain perceived). (NCT03054844)
Timeframe: 10 minutes
Intervention | Units on a scale (Mean) |
---|---|
PREMED | 10.6 |
PREMIX | 10.5 |
I would like to use this method of administering intranasal midazolam and lidocaine again in the future (NCT03054844)
Timeframe: 1 minute
Intervention | Participants (Count of Participants) |
---|---|
PREMED | 8 |
PREMIX | 24 |
1 review available for ketamine and Respiration Disorders
Article | Year |
---|---|
Ketamine, propofol, and ketofol use for pediatric sedation.
Topics: Adolescent; Amnesia; Analgesia; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Antiemetics; An | 2012 |
3 trials available for ketamine and Respiration Disorders
Article | Year |
---|---|
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Randomized, double-blinded, clinical trial of propofol, 1:1 propofol/ketamine, and 4:1 propofol/ketamine for deep procedural sedation in the emergency department.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Deep Sedation; Dose-Response | 2015 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Comparison of propofol/fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Drug Combinations; Emergencies; Emergency S | 2003 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, General; Cir | 2007 |
9 other studies available for ketamine and Respiration Disorders
Article | Year |
---|---|
Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children.
Topics: Anesthesia, Local; Anesthetics, Dissociative; Anesthetics, Local; Child; Child, Preschool; Conscious | 2019 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Ketofol for procedural sedation revisited: pro and con.
Topics: Anesthetics, Dissociative; Deep Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and | 2015 |
Respiratory adverse events during upper digestive endoscopies in children under ketamine sedation.
Topics: Adolescent; Child; Child, Preschool; Conscious Sedation; Deep Sedation; Endoscopy, Digestive System; | 2021 |
Serious adverse events during procedural sedation with ketamine.
Topics: Boston; Case-Control Studies; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospital; F | 2009 |
[Effect of intravenous anesthesia using ketamine on respiratory and circulatory parameters].
Topics: Anesthesia, Intravenous; Animals; Cardiovascular Diseases; Dogs; Hemodynamics; Ketamine; Respiration | 1983 |
Intramuscular ketamine for pediatric sedation in the emergency department: safety profile in 1,022 cases.
Topics: Adolescent; Affective Symptoms; Anesthetics, Dissociative; Apnea; Child; Child, Preschool; Conscious | 1998 |
Frequency of respiratory compromise after ketamine sedation for cardiac catheterization in patients less than 21 years of age.
Topics: Adolescent; Adult; Age Factors; Cardiac Catheterization; Child; Child, Preschool; Conscious Sedation | 1991 |
Anaesthetic experience with paediatric interventional cardiology.
Topics: Adolescent; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Cardiac Surgical P | 1989 |