5-hydroxytryptophan has been researched along with Fatigue in 2 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue better than placebo." | 9.51 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available." | 7.11 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue better than placebo." | 5.51 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available." | 3.11 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Truyens, M | 1 |
| Lobatón, T | 1 |
| Ferrante, M | 1 |
| Bossuyt, P | 1 |
| Vermeire, S | 1 |
| Pouillon, L | 1 |
| Dewint, P | 1 |
| Cremer, A | 1 |
| Peeters, H | 1 |
| Lambrecht, G | 1 |
| Louis, E | 1 |
| Rahier, JF | 1 |
| Dewit, O | 1 |
| Muls, V | 1 |
| Holvoet, T | 1 |
| Vandermeulen, L | 1 |
| Peeters, A | 1 |
| Gonzales, GB | 1 |
| Bos, S | 1 |
| Laukens, D | 1 |
| De Vos, M | 1 |
| Yamamoto, T | 1 |
| Newsholme, EA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicentric, Double-blind, Placebo Controlled Clinical Trial With 5-hydroxytryptophan (5-HTP) in Patients With Inflammatory Bowel Disease in Clinical and Biologic Remission: Effect on Fatigue Scores[NCT03574948] | Phase 2 | 175 participants (Actual) | Interventional | 2018-12-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 5-hydroxytryptophan and Fatigue
| Article | Year |
|---|---|
Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
Topics: 5-Hydroxytryptophan; Chronic Disease; Fatigue; Humans; Inflammatory Bowel Diseases; Serotonin; Trypt | 2022 |
1 other study available for 5-hydroxytryptophan and Fatigue
| Article | Year |
|---|---|
Diminished central fatigue by inhibition of the L-system transporter for the uptake of tryptophan.
Topics: 5-Hydroxytryptophan; Amino Acid Transport Systems; Amino Acids; Amino Acids, Branched-Chain; Amino A | 2000 |