17-ketosteroids and Fatigue

This cohort study of primiparae was conducted to answer the following questions: Do older (≧ 35 years) and younger (20-29 years) Japanese primiparous mothers differ when comparing biomarkers of stress and measures of fatigue and depression? Are there changes in fatigue, depression and stress biomarkers when comparing older and younger mothers during the postpartum period? The Postnatal Accumulated Fatigue Scale and the Edinburgh Postnatal Depression Scale were administered in a time-series method four times: shortly after birth and monthly afterwards. Assays to measure biomarkers of stress, urinary 17-ketosteroids, urinary 17-hydroxycorticosteroids and salivary chromogranin-A, were collected shortly after delivery and at 1 month postpartum in both groups and a third time in older mothers at the 4th month. Statistical testing showed very little difference in fatigue, depression or stress biomarkers between older and younger mothers shortly after birth or 1 month later. Accumulated fatigue and depression scores of older mothers were highest 1 month after delivery. Additional cohort studies are required to characterize physical/psychological well-being of older Japanese primiparae.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Biomarkers; Chromogranin A; Cohort Studies; Depression, Postpartum; Fatigue; Female; Humans; Japan; Maternal Age; Parity; Postpartum Period; Saliva; Stress, Psychological; Young Adult

We examined availability of urinary 17-KS-S to evaluate work and job strain by presented the results in two field research and one experiment. It became clear that urinary S/OH was a comprehensive parameter of thermal strain, under the combined load condition of temperature and exercise, and as an additional factor, under the various load conditions of air velocity. Significant changes of urinary S/OH before and after the rest break and holiday suggested that the findings reflected fatigue conditions. This suggestion was strongly supported by the finding that the values of urinary S/OH on the first day-off after a mid-night shift and those 1 to 3 days later were not able to recover to the value before the night shift. A ratio between urinary 17-KS-S and 17-OHCS, S/OH, suggests a method of evaluating the degree of strain and the condition of fatigue and over-fatigue by measuring these parameters and thus clarifying the work conditions and work-place environment.

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Fatigue; Hot Temperature; Humans; Occupational Exposure; Stress, Physiological; Work

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Age Factors; Aged; Fatigue; Humans; Hydrocortisone; Middle Aged; Pituitary Gland; Stress, Physiological; Surgical Procedures, Operative

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Gland Diseases; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Dexamethasone; Fatigue; Fever; Humans; Hyperplasia; Male; Pituitary-Adrenal Function Tests; Prednisone; Urine

Topics: 17-Ketosteroids; Body Fluids; Disease; Fatigue; Hormones; Muscles; Muscular Diseases