gossypol has been researched along with Fatigue in 2 studies
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gossypol plasma levels were measured (n = 8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n = 4)." | 6.70 | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. ( Bacotti, D; Bloch, R; Borgen, P; Gollub, M; Hudis, C; Ligueros, M; Moasser, MM; Norton, L; Reidenberg, MM; Seidman, AD; Sklarin, N; Sonenberg, M; Van Poznak, C; Van Zee, K; Yao, TJ, 2001) |
| "Gossypol plasma levels were measured (n = 8) and the modulation of the retinoblastoma (Rb) gene protein and Cyclin D1 was assessed by serial biopsies (n = 4)." | 2.70 | Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial. ( Bacotti, D; Bloch, R; Borgen, P; Gollub, M; Hudis, C; Ligueros, M; Moasser, MM; Norton, L; Reidenberg, MM; Seidman, AD; Sklarin, N; Sonenberg, M; Van Poznak, C; Van Zee, K; Yao, TJ, 2001) |
| " The optimal oral dosage of gossypol has been found to be 20 mg/day." | 1.27 | [The clinical study of gossypol in 8,806 men]. ( , 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Van Poznak, C | 1 |
| Seidman, AD | 1 |
| Reidenberg, MM | 1 |
| Moasser, MM | 1 |
| Sklarin, N | 1 |
| Van Zee, K | 1 |
| Borgen, P | 1 |
| Gollub, M | 1 |
| Bacotti, D | 1 |
| Yao, TJ | 1 |
| Bloch, R | 1 |
| Ligueros, M | 1 |
| Sonenberg, M | 1 |
| Norton, L | 1 |
| Hudis, C | 1 |
1 trial available for gossypol and Fatigue
| Article | Year |
|---|---|
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Cell Cycle; Cyclin D1; Dose-Response Relationsh | 2001 |
1 other study available for gossypol and Fatigue
| Article | Year |
|---|---|
[The clinical study of gossypol in 8,806 men].
Topics: Asia; Asia, Eastern; China; Contraception; Contraceptive Agents; Contraceptive Agents, Male; Develop | 1985 |