propofol and Fatigue studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.

Research Excerpts

Excerpt	Relevance	Reference
"Fatigue may delay functional recovery after day surgery and may be more common after propofol anaesthesia."	9.24	A randomised controlled trial of propofol vs. thiopentone and desflurane for fatigue after laparoscopic cholecystectomy. ( Bernklev, T; Doksrod, TS; Fredheim, OM; Mohus, RM; Nostdahl, T; Raeder, J, 2017)
"Propofol is a wildly used general anesthetic in clinic, and inspired by the rapid antidepressant effects induced by ketamine at non-anesthetic dose, the present study was undertaken to investigate the anti-fatigue effects and underlying mechanisms of propofol at a non-anesthetic dose in 70% hepatectomy induced POF model in rats."	5.72	Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids beta-oxidation. ( Li, JC; Li, S; Li, Y; Mi, TY; Shen, XM; Wang, HL; Wang, LX; Xue, R; Yin, XL; Zhang, WW; Zhang, Y; Zhang, YZ, 2022)
"Fatigue may delay functional recovery after day surgery and may be more common after propofol anaesthesia."	5.24	A randomised controlled trial of propofol vs. thiopentone and desflurane for fatigue after laparoscopic cholecystectomy. ( Bernklev, T; Doksrod, TS; Fredheim, OM; Mohus, RM; Nostdahl, T; Raeder, J, 2017)
"Surgery-induced acute postoperative pain and stress response can lead to prolonged convalescence."	2.82	Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Hysterectomy: a Double-Blind, Randomized Clinical Trial. ( Ge, DJ; Li, JY; Qi, B; Tang, G, 2016)
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."	2.75	Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."	2.74	The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)
"Propofol has different and more favourable influences on the post-operative mood state than does methohexitone."	2.67	Propofol and methohexitone anaesthesia: effects on the profile of mood state. ( Camu, F; D'Haenen, HA; D'Haese, J; Dekeyzer, PJ, 1994)
"Propofol is a wildly used general anesthetic in clinic, and inspired by the rapid antidepressant effects induced by ketamine at non-anesthetic dose, the present study was undertaken to investigate the anti-fatigue effects and underlying mechanisms of propofol at a non-anesthetic dose in 70% hepatectomy induced POF model in rats."	1.72	Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids beta-oxidation. ( Li, JC; Li, S; Li, Y; Mi, TY; Shen, XM; Wang, HL; Wang, LX; Xue, R; Yin, XL; Zhang, WW; Zhang, Y; Zhang, YZ, 2022)

Research

Studies (10)

Authors

Clinical Trials (13)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (20.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	1 (10.00)	2.80

Authors	Studies
Zhang, WW	1
Xue, R	1
Mi, TY	1
Shen, XM	1
Li, JC	1
Li, S	1
Zhang, Y	1
Li, Y	1
Wang, LX	1
Yin, XL	1
Wang, HL	1
Zhang, YZ	1
Nostdahl, T	1
Fredheim, OM	1
Bernklev, T	1
Doksrod, TS	1
Mohus, RM	1
Raeder, J	1
Forster, C	1
Vanhaudenhuyse, A	1
Gast, P	1
Louis, E	1
Hick, G	1
Brichant, JF	1
Joris, J	1
Ge, DJ	1
Qi, B	1
Tang, G	1
Li, JY	1
Türe, H	1
Sayin, M	1
Karlikaya, G	1
Bingol, CA	1
Aykac, B	1
Türe, U	1
Galvin, E	1
Boesjes, H	1
Hol, J	1
Ubben, JF	1
Klein, J	1
Verbrugge, SJ	1
Bekker, A	1
Haile, M	1
Kline, R	1
Didehvar, S	1
Babu, R	1
Martiniuk, F	1
Urban, M	1
Chung, F	1
Kayumov, L	1
Sinclair, DR	1
Edward, R	1
Moller, HJ	1
Shapiro, CM	1
Rashiq, S	1
Gallant, B	1
Grace, M	1
Jolly, DT	1
D'Haese, J	1
Camu, F	1
Dekeyzer, PJ	1
D'Haenen, HA	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Investigation of the Effects of Intravenous Lidocaine Infusion During Sedation for Colonoscopy[NCT02784860]	Phase 4	40 participants (Actual)	Interventional	2016-03-31	Completed
The Effect of Intravenous Lidocaine on Propofol Requirements in Patients Undergoing Hysteroscopy and Diagnostic Curettage[NCT04633577]		40 participants (Actual)	Interventional	2020-11-20	Completed
Effect of Dexmedetomidine Combined With Dezocine and Flubiprofen for Postoperative Intravenous Patient Controlled Analgesia After Colorectal Surgery[NCT03014713]	Phase 4	50 participants (Anticipated)	Interventional	2016-09-30	Recruiting
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]	Phase 4	105 participants (Actual)	Interventional	2016-02-29	Terminated
Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012971]		1,500 participants (Actual)	Interventional	2017-01-06	Active, not recruiting
Impact of Perioperative Dexmedetomidine on Long-term Outcomes in Elderly Patients After Cardiac Surgery: 6-year Follow-up of a Randomized Controlled Trial[NCT03289325]		285 participants (Actual)	Interventional	2016-12-05	Completed
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 3-year Follow-up of a Randomized Controlled Trial[NCT02809937]	Phase 4	700 participants (Actual)	Interventional	2011-05-31	Completed
Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion[NCT01377623]		66 participants (Actual)	Interventional	2010-09-30	Terminated
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial[NCT02613806]	Phase 4	118 participants (Anticipated)	Interventional	2015-12-31	Not yet recruiting
Effect of Dexmedetomidine as Anesthetic Coadjuvant on Plasmatic Cortisol Response in Transsphenoidal Surgery for Pituitary Tumors[NCT02549768]	Phase 4	40 participants (Anticipated)	Interventional	2015-09-30	Recruiting
Impact of Dexmedetomidine Supplemented Analgesia on Incidence of Delirium in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012984]		1,500 participants (Actual)	Interventional	2017-01-06	Completed
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 5-year Follow-up of a Randomized Controlled Trial[NCT03436472]		700 participants (Actual)	Interventional	2017-06-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Intervention	morphine equivalents (Mean)
Standard of Care	287.0
Postoperative Gabapentin Regimen	281.1

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Postanesthesia Quality Recovery Scale Score

Intervention	minutes (Mean)
Placebo	53.5
Modafinil	61.0

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Concentration of IL-1a

Concentration of IL-6

Concentration of IL-8

Concentration of TNF-alpha

Quality of Recovery Score (QoR-40)

Intervention	units on a scale (Mean)
Placebo	-5.67
Modafinil	-8.91

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	2.52
Placebo Group (PFS)	2.58

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	60.8
Placebo Group (PFS)	50.0

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	20.9
Placebo Group (PFS)	16.4

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	10.1
Placebo Group (PFS)	7.9

The QoR-40 is a 40 item questionnaire in which each question is answered with a score of 1-5. QoR-40 scores range from 40 (extremely poor quality of recovery) to 200 (excellent quality of recovery). (NCT01377623)
Timeframe: Post-operative Day 3

Article	Year
A randomised controlled trial of propofol vs. thiopentone and desflurane for fatigue after laparoscopic cholecystectomy. Anaesthesia, 2017, Volume: 72, Issue:7 Topics: Adult; Cholecystectomy, Laparoscopic; Desflurane; Fatigue; Female; Humans; Male; Middle Aged; Postop	2017
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. British journal of anaesthesia, 2018, Volume: 121, Issue:5 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Colonoscopy; Conscious Sedation; Double	2018
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. British journal of anaesthesia, 2018, Volume: 121, Issue:5 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Colonoscopy; Conscious Sedation; Double	2018
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. British journal of anaesthesia, 2018, Volume: 121, Issue:5 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Colonoscopy; Conscious Sedation; Double	2018
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. British journal of anaesthesia, 2018, Volume: 121, Issue:5 Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Local; Colonoscopy; Conscious Sedation; Double	2018
Intraoperative Dexmedetomidine Promotes Postoperative Analgesia and Recovery in Patients after Abdominal Hysterectomy: a Double-Blind, Randomized Clinical Trial. Scientific reports, 2016, Feb-23, Volume: 6 Topics: Analgesia, Patient-Controlled; Anesthesia, General; Anesthetics, Intravenous; Dexmedetomidine; Doubl	2016
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;	2009
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha	2010
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
Recovery characteristics following induction of anaesthesia with a combination of thiopentone and propofol. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:12 Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Double-Blind Method; D	1994
Propofol and methohexitone anaesthesia: effects on the profile of mood state. European journal of anaesthesiology, 1994, Volume: 11, Issue:5 Topics: Adult; Affect; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anxiety; Attitude; Cognition	1994

Article	Year
Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids beta-oxidation. Biochemical and biophysical research communications, 2022, 01-01, Volume: 586 Topics: Acetyl Coenzyme A; Animals; Carnitine O-Palmitoyltransferase; CREB-Binding Protein; Fatigue; Fatty A	2022
What is the driving performance of ambulatory surgical patients after general anesthesia? Anesthesiology, 2005, Volume: 103, Issue:5 Topics: Adjuvants, Anesthesia; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthetics, Intr	2005

propofol and Fatigue