A sulfide:quinone oxidoreductase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y6N5]
SQOR;
EC 1.8.5.8;
Sulfide dehydrogenase-like;
Sulfide quinone oxidoreductase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0) | 18.7374 |
| 1990's | 0 (0) | 18.2507 |
| 2000's | 0 (0) | 29.6817 |
| 2010's | 0 (0) | 24.3611 |
| 2020's | 0 (0) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| carmofur | Homo sapiens (human) | IC50 | 20.0000 | 1 | 0 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| quinone binding | molecular function | Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732] |
| sulfide:quinone oxidoreductase activity | molecular function | Catalysis of the reaction: H2S (hydrogen sulfide) + a quinone = S0 (sulfane sulfur) + a hydroquinone. [RHEA:30239] |
| glutathione-dependent sulfide quinone oxidoreductase activity | molecular function | Catalysis of the reaction: a quinone + glutathione + H+ + hydrogen sulfide = a quinol + S-sulfanylglutathione. [RHEA:55156] |
| FAD binding | molecular function | Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| sulfide oxidation, using sulfide:quinone oxidoreductase | biological process | A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase. [MetaCyc:P222-PWY] |