hydroxyindoleacetic acid has been researched along with Fatigue in 15 studies
(5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonin, a neurotransmitter synthesized from tryptophan, has been proposed to play a key role in central fatigue." | 7.78 | Essential role of excessive tryptophan and its neurometabolites in fatigue. ( Azechi, H; Board, M; Yamamoto, T, 2012) |
| "Losartan (Los) was intracerebroventricularly injected in rats before running until fatigue (n = 6 per group)." | 7.76 | Central fatigue induced by losartan involves brain serotonin and dopamine content. ( Coimbra, CC; Leite, LH; Marubayashi, U; Rodrigues, AG; Soares, DD, 2010) |
| "Serotonin, a neurotransmitter synthesized from tryptophan, has been proposed to play a key role in central fatigue." | 3.78 | Essential role of excessive tryptophan and its neurometabolites in fatigue. ( Azechi, H; Board, M; Yamamoto, T, 2012) |
| "Losartan (Los) was intracerebroventricularly injected in rats before running until fatigue (n = 6 per group)." | 3.76 | Central fatigue induced by losartan involves brain serotonin and dopamine content. ( Coimbra, CC; Leite, LH; Marubayashi, U; Rodrigues, AG; Soares, DD, 2010) |
| " Dose-response curves created with 8-OH DPAT for the serotonin behavioral syndrome were similar in bile duct-resected and sham-operated rats." | 1.33 | Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat. ( Bozdayi, AM; Bozkaya, H; Celik, T; Cinar, K; Gören, MZ; Gürdal, H; Onder, FO; Tan, A; Terzioğlu, B; Uzunalimoğlu, O; Yurdaydin, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabelo, PC | 1 |
| Almeida, TF | 1 |
| Guimarães, JB | 1 |
| Barcellos, LA | 1 |
| Cordeiro, LM | 1 |
| Moraes, MM | 1 |
| Coimbra, CC | 2 |
| Szawka, RE | 1 |
| Soares, DD | 2 |
| Liu, Z | 1 |
| Wu, Y | 1 |
| Liu, T | 1 |
| Li, R | 1 |
| Xie, M | 1 |
| Leite, LH | 1 |
| Rodrigues, AG | 1 |
| Marubayashi, U | 1 |
| Liu, HZ | 1 |
| Zeng, L | 1 |
| Kong, XL | 1 |
| Zhu, I | 1 |
| Ma, YC | 1 |
| Yamamoto, T | 2 |
| Azechi, H | 1 |
| Board, M | 1 |
| Tanaka, M | 1 |
| Nakamura, F | 1 |
| Mizokawa, S | 1 |
| Matsumura, A | 1 |
| Nozaki, S | 1 |
| Watanabe, Y | 1 |
| Newsholme, EA | 1 |
| Celik, T | 1 |
| Gören, MZ | 2 |
| Cinar, K | 1 |
| Gürdal, H | 1 |
| Onder, FO | 1 |
| Tan, A | 1 |
| Terzioğlu, B | 2 |
| Bozdayi, AM | 1 |
| Bozkaya, H | 1 |
| Uzunalimoğlu, O | 1 |
| Yurdaydin, C | 2 |
| Aypak, C | 1 |
| Yananli, HR | 1 |
| Küçükibrahimoğlu, E | 1 |
| Nguyen, H | 1 |
| Wang, H | 1 |
| le, T | 1 |
| Ho, W | 1 |
| Sharkey, KA | 1 |
| Swain, MG | 1 |
| Bianchi, GP | 1 |
| Grossi, G | 1 |
| Bargossi, AM | 1 |
| Davis, JM | 1 |
| Alderson, NL | 1 |
| Welsh, RS | 1 |
| Helander, A | 1 |
| Some, M | 1 |
| Gomez-Merino, D | 1 |
| Béquet, F | 1 |
| Berthelot, M | 1 |
| Chennaoui, M | 1 |
| Guezennec, CY | 1 |
| Cremata, VY | 1 |
| Koe, BK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain During Effort : Effects of Hypoxia With Respiratory Patients[NCT02854280] | 33 participants (Actual) | Interventional | 2013-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyindoleacetic acid and Fatigue
| Article | Year |
|---|---|
Serotonin and central nervous system fatigue: nutritional considerations.
Topics: Amino Acids, Branched-Chain; Animals; Brain; Carbohydrate Metabolism; Carbohydrates; Dietary Supplem | 2000 |
1 trial available for hydroxyindoleacetic acid and Fatigue
| Article | Year |
|---|---|
Clinical and biochemical effects of fenclonine: a serotonin depletor.
Topics: Adult; Fatigue; Headache; Humans; Hydroxyindoleacetic Acid; Male; Nausea; Phenylalanine; Placebos; S | 1968 |
13 other studies available for hydroxyindoleacetic acid and Fatigue
| Article | Year |
|---|---|
Intrinsic exercise capacity is related to differential monoaminergic activity in the rat forebrain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Caudate Nucleus; Dopamine; Fatigue; Hy | 2015 |
Serotonin regulation in a rat model of exercise-induced chronic fatigue.
Topics: Animals; Brain; Chronic Disease; Fatigue; Hydroxyindoleacetic Acid; Male; Physical Conditioning, Ani | 2017 |
Central fatigue induced by losartan involves brain serotonin and dopamine content.
Topics: 3,4-Dihydroxyphenylacetic Acid; Angiotensin II Type 1 Receptor Blockers; Animals; Body Temperature; | 2010 |
[Effects of Chinese herbal compound on monoamine and neuronal amino acids in rat's telencephalon in the course of exhaustion and recovery process].
Topics: Amino Acids; Animals; Biogenic Monoamines; Drugs, Chinese Herbal; Fatigue; Hydroxyindoleacetic Acid; | 2011 |
Essential role of excessive tryptophan and its neurometabolites in fatigue.
Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; | 2012 |
Establishment and assessment of a rat model of fatigue.
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Fatigue; Hydroxyindoleacetic Acid; Male; Rats; Rat | 2003 |
The effect of tryptophan deficiency in the brain on rat fatigue levels: a rat model of fatigue reduction.
Topics: Animals; Brain; Corpus Striatum; Fatigue; Female; Hydroxyindoleacetic Acid; Motor Activity; Rats; Ra | 2003 |
Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Cholestasis; Dose-Response | 2005 |
5-hydroxytryptamine release in the anterior hypothalamic and the hippocampal areas of cholestatic rats.
Topics: Animals; Bile Ducts; Cholestasis; Chromatography, High Pressure Liquid; Fatigue; Hippocampus; Hydrox | 2006 |
Downregulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats.
Topics: Alanine Transaminase; Animals; Bilirubin; Blotting, Western; Cholestasis; Down-Regulation; Fatigue; | 2008 |
May peripheral and central fatigue be correlated? Can we monitor them by means of clinical laboratory tools?
Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; Biomarkers; Chromatography, High Pressure Liquid; F | 1997 |
Dietary serotonin and alcohol combined may provoke adverse physiological symptoms due to 5-hydroxytryptophol.
Topics: Adult; Alcohol Drinking; Diarrhea; Diet; Drug Synergism; Ethanol; Fatigue; Female; Headache; Humans; | 2000 |
Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain.
Topics: Animals; Extracellular Space; Fatigue; Frontal Lobe; Hippocampus; Hydroxyindoleacetic Acid; Male; Mi | 2001 |