17-methylandrost-2-en-17-ol profile

17-methylandrost-2-en-17-ol is a synthetic steroid that is structurally related to testosterone. It's important for research because:

**1. It's a potent androgen receptor (AR) agonist:** This means it binds to and activates the AR, which is a protein involved in the development and function of male sexual characteristics. This makes it useful in studying the role of AR in various physiological and pathological processes.

**2. It's a potential therapeutic agent:** Due to its potent androgenic activity, it has been explored as a potential treatment for conditions like hypogonadism (low testosterone) and muscle wasting.

**3. It's a valuable research tool:** 17-methylandrost-2-en-17-ol serves as a valuable tool for researchers investigating:

* **The role of AR in various tissues and conditions:** It can help determine the involvement of AR in different diseases and the potential for targeting AR to develop new therapies.
* **The mechanisms of action of AR agonists:** It can be used to study how AR agonists work at the molecular level and to identify new targets for drug development.
* **The development of novel androgenic drugs:** Its structure and activity provide a starting point for the design of new androgenic drugs with improved efficacy and safety profiles.

**However, it's important to note:**

* 17-methylandrost-2-en-17-ol is not currently approved for therapeutic use in humans.
* Its use in research is regulated and requires careful consideration of its potential risks and benefits.

**Further research is ongoing to explore the full therapeutic potential and safety profile of 17-methylandrost-2-en-17-ol.**

17-methylandrost-2-en-17-ol: a designer steroid; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	4010235
MeSH ID	M0484630

Synonym
NCIOPEN2_002832
DTXSID10863143
17-methylandrost-2-en-17-ol

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (50.00)	29.6817
2010's	4 (50.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (22.22%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (77.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methyl methanesulfonate [no description available]	2.04	1	methanesulfonate ester	alkylating agent; apoptosis inducer; carcinogenic agent; genotoxin; mutagen
testosterone propionate Testosterone Propionate: An ester of TESTOSTERONE with a propionate substitution at the 17-beta position.. androgen : A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.	2.06	1	steroid ester
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	2.46	2	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.04	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
19-norandrostenedione 19-norandrostenedione: structure	2.46	2	3-oxo steroid
oxymetholone Oxymetholone: A synthetic hormone with anabolic and androgenic properties. It is used mainly in the treatment of anemias. According to the Fourth Annual Report on Carcinogens (NTP 85-002), this compound may reasonably be anticipated to be a carcinogen. (From Merck Index, 11th ed). oxymetholone : A 3-oxo-5alpha- steroid that is 4,5alpha-dihydrotestosterone which is substituted by a hydroxymethylidene group at position 2 and by a methyl group at the 17alpha position. A synthetic androgen, it was mainly used for the treatment of anaemias until being replaced by treatments with fewer side effects.	2.07	1

Condition	Relationship Strength	Studies
Dyslipidemia [description not available]	2.13	1
Acute Liver Injury, Drug-Induced [description not available]	2.13	1
Lassitude [description not available]	2.13	1
Icterus [description not available]	2.13	1
Itching [description not available]	2.13	1
Fatigue The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.	2.13	1
Jaundice A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.	2.13	1
Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	2.13	1
Dyslipidemias Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.	2.13	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.13	1
Chromosome-Defective Micronuclei [description not available]	2.04	1

17-methylandrost-2-en-17-ol

Description

Cross-References

Synonyms (3)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.21

Study Types