digoxin and Fatigue

Topics: Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Digitalis Glycosides; Digoxin; Diuretics; Electrocardiography; Fatigue; Female; Gastrointestinal Diseases; Glucose; Heart Block; Humans; Lidocaine; Male; Middle Aged; Phenytoin; Poisoning; Potassium; Procainamide; Saliva; Tachycardia; Time Factors; Vision Disorders

Topics: Anorexia Nervosa; Color Vision Defects; Digitalis Glycosides; Digitoxin; Digoxin; Eye Manifestations; Fatigue; Humans; Medication Errors; Mental Disorders; Muscular Diseases; Nausea; Neurologic Manifestations; Poisoning; Vision Disorders

We investigated whether digoxin lowered muscle Na

Topics: Adult; Digoxin; Fatigue; Humans; Muscle, Skeletal; Ouabain; Sodium; Sodium-Potassium-Exchanging ATPase

Topics: Adult; Blood Pressure; Body Temperature; Digoxin; Fatigue; Heart Rate; Humans; Male; Methods; Middle Aged; Monitoring, Physiologic; Oxygen Consumption; Physical Exertion; Placebos; Regional Blood Flow

Topics: Acute Kidney Injury; Aged; Agglutinins; Anti-Arrhythmia Agents; Atrial Fibrillation; Bradycardia; Digoxin; Dosage Forms; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Fatigue; Humans; Male; Treatment Outcome; Vision Disorders; Vomiting

Supraventricular tachycardia is uncommon in pregnancy. It is defined as intermittent pathological and usually narrow complex tachycardia >120 beats/min which originates above the ventricle, excluding atrial fibrillation, flutter and multifocal atrial tachycardia. It is usually self-limiting or relatively easily treated with most cases responding to physical or pharmacological therapies. We describe a case of a woman in the third trimester of pregnancy who developed treatment-resistant supraventricular tachycardia and required induction of labour and delivery to stop the arrhythmia. A multidisciplinary team approach with a critical care trained nurse and a midwife, continuous arterial blood pressure monitoring, transthoracic echocardiography, and neuraxial analgesia facilitated safe birth in the delivery suite and termination of the arrhythmia.

Topics: Adult; Amides; Amnion; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Arrhythmia Agents; Delivery, Obstetric; Digoxin; Dyspnea; Echocardiography; Fatigue; Female; Fentanyl; Flecainide; Humans; Labor, Obstetric; Metoprolol; Oximetry; Oxytocics; Oxytocin; Pregnancy; Pregnancy Complications, Cardiovascular; Ropivacaine; Tachycardia, Supraventricular

Topics: Aged; Angioplasty, Balloon, Coronary; Cardiovascular Agents; Coronary Artery Disease; Digoxin; Drug-Eluting Stents; Fatigue; Humans; Male; Physician-Patient Relations

Topics: Child, Preschool; Digoxin; Drug Administration Schedule; Fatigue; Heart Diseases; Humans; Infant; Sleep

In 1148 cases the serum digoxin concentration (SDC) was correlated with the extracardiac signs of digitalis intoxication. There is a considerably overlap of SDC levels of patients with and without extracardiac signs of toxicity even though the mean SDC's of these two groups differ significantly. An increasing percentage of clinical intoxicated patients with increasing SDC levels was found at digoxin concentrations of 2.0 ng/ml and higher. At lower SDC levels patients with and without extracardiac signs of digitalis intoxication did not differ significantly in their mean SDC but in mean age and in mean creatinine concentration indicating that at least part of the symptoms in these patients might be due to a more severe illness. We could show that many of the extracardiac signs of digitalis intoxication are also seen in patients with impaired kidney function at low SDC levels and may lead to a wrong diagnosis. The most common complaint in patients with SDC's of 2.0 ng/ml and more is nausea (39.4%), followed by tiredness (30.4%), dizzyness (23.7%), vomiting (23.1%), headache (16.0%), visual disturbances (13,5%), colour (yellow) seeing (6;7%), diarrhea (4.2%) and severe neuro-psychiatric disturbances (3.8%). In patients with digitalis-induced arrhythmias the sequence of symptoms is the same only with a somewhat higher percentage rate. Only about one half of the patients with digitalis-induced arrhythmias and SDC values up to 2.5 ng/ml showed also extracardiac signs of intoxication. Therefore these signs are not to be taken as early symptoms of digitalis intoxication. Divided into subgroups (patients with/without digitalis-induced arrhythmias, patients with SDC values of more/less than 2.0 ng/ml) the patients with and without extracardiac signs of digitalis toxicity are compared with each other in regard to: mean body height and weight, concentration of digoxin, potassium and creatinine, digoxin dosage and mean age. The greatest differences were found between patients with combined cardiac and extracardiac signs of intoxication and patients with neither cardiac nor extracardiac signs of intoxication: These intoxicated patients are of significantly higher mean age and lower body weight, their mean concentration of digoxin and creatinine and the digoxin dosage administered are significantly greater, but there is no significant difference in potassium concentration. An important group of patients, namely the elderly with impaired kidney function, are especially p

Topics: Age Factors; Creatinine; Diarrhea; Digoxin; Electrocardiography; Fatigue; Headache; Humans; Nausea; Vertigo; Vision Disorders; Vomiting