clonazepam has been researched along with Fatigue in 4 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "At the therapeutic endpoint, clonazepam (N = 222) proved clinically and statistically superior to placebo (N = 216) in change in the number of panic attacks and in Clinical Global Impressions-Severity of Illness (CGI-S) and CGI-Change scores, Patient's Global Impression of Change scores, amount of fear and avoidance associated with phobic symptoms, and duration of anticipatory anxiety." | 9.09 | Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages. ( Moroz, G; Rosenbaum, JF, 1999) |
| "At the therapeutic endpoint, clonazepam (N = 222) proved clinically and statistically superior to placebo (N = 216) in change in the number of panic attacks and in Clinical Global Impressions-Severity of Illness (CGI-S) and CGI-Change scores, Patient's Global Impression of Change scores, amount of fear and avoidance associated with phobic symptoms, and duration of anticipatory anxiety." | 5.09 | Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages. ( Moroz, G; Rosenbaum, JF, 1999) |
| "Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged-release melatonin (Circadin) or matched placebo, ingested orally once-daily before bedtime." | 2.94 | Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial. ( Coeytaux Jackson, A; Fang, BAM; Gilat, M; Grunstein, RR; Hall, JM; Hammond, D; Lewis, SJG; Marshall, NS; Mullins, AE; Wong, KKH; Yee, BJ, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gilat, M | 1 |
| Coeytaux Jackson, A | 1 |
| Marshall, NS | 1 |
| Hammond, D | 1 |
| Mullins, AE | 1 |
| Hall, JM | 1 |
| Fang, BAM | 1 |
| Yee, BJ | 1 |
| Wong, KKH | 1 |
| Grunstein, RR | 1 |
| Lewis, SJG | 1 |
| Moroz, G | 1 |
| Rosenbaum, JF | 1 |
| Fazio, C | 1 |
| Manfredi, M | 1 |
| Piccinelli, A | 1 |
| Wollman, M | 1 |
| Lavie, P | 1 |
| Peled, R | 1 |
2 trials available for clonazepam and Fatigue
| Article | Year |
|---|---|
Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.
Topics: Aged; Clonazepam; Double-Blind Method; Eye Movements; Fatigue; Female; Humans; Male; Melatonin; Midd | 2020 |
Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages.
Topics: Adolescent; Adult; Aged; Agoraphobia; Ambulatory Care; Clonazepam; Comorbidity; Double-Blind Method; | 1999 |
2 other studies available for clonazepam and Fatigue
| Article | Year |
|---|---|
Treatment of epileptic seizures with clonazepam. A reappraisal.
Topics: Administration, Oral; Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Drug Administ | 1975 |
A hypernychthemeral sleep-wake syndrome: a treatment attempt.
Topics: Adult; Circadian Rhythm; Clonazepam; Depression; Fatigue; Humans; Male; Sleep Wake Disorders | 1985 |