Page last updated: 2024-10-14

zk-219477

Description

sagopilone: has antineoplastic activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11284169
CHEMBL ID2304041
CHEBI ID177512
SCHEMBL ID423579
MeSH IDM0543975

Synonyms (40)

Synonym
(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-prop-2-enyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
CHEBI:177512
305841-29-6
zk-219477
zk epothilone
de-03757
sh-y03757a
sagopilone
zk-epo
epo-477
sagopilone (usan/inn)
D09721
zk 219477
sagopilone [usan:inn]
sh y03757a
zk-epothilone
ky72ju32fo ,
4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione, 7,11-dihydroxy-8,8,12,16- tetramethyl-3-(2-methyl-5-benzothiazolyl)-10-(2-propenyl)-, (1s,3s,7s,10r,11s,12s,16r)-
de 03757
bay 86-5302
sh-y-03757
(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
bay-86-5302
unii-ky72ju32fo
CHEMBL2304041
bay86-5302
zk219477
SCHEMBL423579
sagopilone [inn]
(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3- benzothiazol-5-yl)-10-(prop-2-enyl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
sagopilone [who-dd]
(1s,3s,7s,10r,11s,12s,16r)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
sagopilone [usan]
(1s,3s,7s,10r,11s,12s,16r)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methylbenzothiazol-5-yl)-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione, 7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-5-benzothiazolyl)-10-(2-propenyl)-, (1s,3s,7s,10r,11s,12s,16r)-
DB12391
(1s,3s,7s,10r,11s,12s,16r)-10-allyl-7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methylbenzo[d]thiazol-5-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Q27282501
7,11-dihydroxy-8,8,12,16-tetramethyl-3-(2-methyl-1,3-benzothiazol-5-yl)-10-(prop-2-en-1-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
DTXSID30952866

Toxicity

ExcerptReference
" The main treatment-related adverse events were sensory neuropathy (81."( Phase II study evaluating the efficacy and safety of sagopilone (ZK-EPO) in patients with metastatic breast cancer that has progressed following chemotherapy.
Divers, S; Giurescu, M; Hortobagyi, GN; Luoh, SW; Morrow, PK; Petrella, TM; Provencher, L; Schmelter, T; Vahdat, LT; Wang, Y, 2010
)
"Since peripheral sensory neuropathy is the major, clinically relevant side effect of sagopilone we investigated the general and peripheral neurotoxicity of sagopilone administered intravenously with different doses (1."( Exposure-response relationship of the synthetic epothilone sagopilone in a peripheral neurotoxicity rat model.
Avezza, F; Canta, A; Carozzi, VA; Cavaletti, G; Ceresa, C; Chiorazzi, A; Crippa, L; Höchel, J; Meregalli, C; Oggioni, N; Sala, B; Stöckigt, D, 2012
)
" The most frequently reported adverse event (AE) was peripheral sensory neuropathy (75%)."( Prospective, multicenter, randomized, independent-group, open-label phase II study to investigate the efficacy and safety of three regimens with two doses of sagopilone as second-line therapy in patients with stage IIIB or IV non-small-cell lung cancer.
Brune, A; Eschbach, C; Fischer, JR; Heigener, DF; Reck, M; Schmelter, T; Schmittel, A; von Pawel, J, 2013
)
"Peripheral neuropathy (PN) is a recognized side effect of microtubule-targeting agents and the most clinically relevant toxicity observed with the epothilone sagopilone (SAG)."( A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy.
Baurain, JF; Berton-Rigaud, D; Campone, M; de Bont, N; Fabbro, M; Joly-Lobbedez, F; Pautier, P; Pinkert, J; Rolland, F; Schmelter, T; Stenzl, A; van Dijk, M, 2013
)

Compound-Compound Interactions

ExcerptReference
" Here we report the first phase-I trial of sagopilone in combination with cisplatin in previously untreated metastatic small-cell lung cancer patients."( Phase-I study of sagopilone in combination with cisplatin in chemotherapy-naive patients with metastasised small-cell lung cancer.
Christoph, DC; Eberhardt, WE; Fischer, J; Frickhofen, N; Gauler, TC; Giurescu, M; Gonschorek, C; Huber, R; Roth, K, 2013
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
macrolideA macrocyclic lactone with a ring of twelve or more members derived from a polyketide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (29)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (24.14)29.6817
2010's22 (75.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials15 (50.00%)5.53%
Reviews3 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]