Compounds > sjg 136
Page last updated: 2024-12-08

sjg 136

Description

1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione): structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID393111
CHEMBL ID16498
SCHEMBL ID12020905
MeSH IDM0475187

Synonyms (35)

Synonym
sjg 136
232931-57-6
NCI60_033825
up 2001
nsc694501
nsc-694501
5h-pyrrolo[2,4]benzodiazepin-5-one, 8,8'-[1,3-propanediylbis(oxy)]bis[1,2,3,11a-tetrahydro- 7-methoxy-2-methylene-, (11as, 11'as)-
sg-2000
sjg-136
CHEMBL16498
up-2001
sp-2001
bn-2629
(6as)-3-[3-[[(6as)-2-methoxy-8-methylidene-11-oxo-7,9-dihydro-6ah-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-methylidene-7,9-dihydro-6ah-pyrrolo[2,1-c][1,4]benzodiazepin-11-one
kt0zq64x1a ,
unii-kt0zq64x1a
sjg136
1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione)
nsc 694501
CS-4593
SCHEMBL12020905
HY-14573
sjg 136 [who-dd]
(6as)-3-(3-(((6as)-2-methoxy-8-methylene-11-oxo-7,9-dihydro-6ah-pyrrolo(2,1-c)(1,4)benzodiazepin-3-yl)oxy)propoxy)-2-methoxy-8-methylene-7,9-dihydro-6ah-pyrrolo(2,1-c)(1,4)benzodiazepin-11-one
5h-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 8,8'-(1,3-propanediylbis(oxy))bis(1,2,3,11a-tetrahydro-7-methoxy-2-methylene-, (11as,11'as)-
DTXSID20177864
AKOS027326601
DB11965
(11as,11a's)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5h-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one)
5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 8,8'-[1,3-propanediylbis(oxy)]bis[1,2,3,11a-tetrahydro-7-methoxy-2-methylene-, (11as,11'as)-
Q27282424
C74198
A858346
(11as,11a's)-8,8'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5h-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one);1,1'-(propane-1,3-diylbis(oxy))bis(7-methoxy-2-methylene-1,2,3,11a-tetrahydro-5h-benzo[e]pyrrolo[1,2-a][1,4]diazepine-
BS-42683

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" This study examines the pharmacological characteristics of SJG-136 and provides the first report of pharmacokinetic properties for this agent."( Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.
Cooper, P; Howard, PW; Jenkins, TC; Loadman, PM; Shnyder, S; Taylor, JP; Thurston, DE; Wilkinson, GP, 2004)		0.32
" Following treatment with an intraperitoneal injection, fibres were excised and cells retrieved for pharmacodynamic analysis using the comet assay/fluorescence microscopy."( The hollow fibre model--facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare.
Bibby, MC; Cooper, PA; Shnyder, SD; Suggitt, M, 2006)		0.33
"To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs."( γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J, 2013)		0.39
" An increased γ-H2AX response was observed during the second cycle consistent with a cumulative pharmacodynamic effect."( γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J, 2013)		0.39
"This is the first use of γ-H2AX as a pharmacodynamic response to a DNA cross-linking agent in a clinical trial setting."( γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J, 2013)		0.39

Dosage Studied

ExcerptRelevanceReference
" Alternative clinical dosing strategies are being evaluated."( Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.
Begent, RH; Clingen, PH; Cobb, M; Gumbrell, L; Hartley, JA; Hochhauser, D; Jodrell, D; Loadman, P; Meyer, T; Spanswick, VJ; Wu, J, 2009)		0.35
" Alternative dosing strategies are now being evaluated."( A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors.
Azzoli, CG; Calcutt, MW; Janjigian, YY; Kris, MG; Krug, LM; Lee, W; Miller, VA; Rizvi, NA; Senturk, E, 2010)		0.36
" Substantial changes in volume of distribution at steady-state occurred after repeated dosing in some patients prior to the onset of edema."( Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.
Berlin, JD; Calcutt, MW; Chen, AP; Hachey, DL; Hartley, JA; Lee, W; Liao, CY; Puzanov, I; Rothenberg, ML; Spanswick, VJ; Vermeulen, WL, 2011)		0.37
"γ-H2AX foci formation was validated preclinically in comparison with the Comet assay, and evaluated pharmacodynamically in two phase I studies of different dosing schedules of the novel cross-linking agent SJG-136 (SG2000)."( γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).
Clingen, PH; Hartley, JA; Hochhauser, D; Jodrell, D; Mellinas-Gomez, M; Meyer, T; Puzanov, I; Spanswick, VJ; Wu, J, 2013)		0.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID224602Compound dose required to induce 50 percent cross linking in naked plasmid pBR322 DNA following incubation with agent for 2 hours at 37 degree C2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID94620Dose required to induce 50 percent decrease in tail moment of the DNA of K562 cells following a 1 hour treatment2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID321351Cytotoxicity against human NCI60 cells2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
AID471718Cytotoxicity against human K562 cells by alamar blue assay2009Bioorganic & medicinal chemistry letters, Nov-15, Volume: 19, Issue:22
Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
AID392957Binding affinity to calf thymus DNA assessed as change in melting temperature at a compound to DNA molar ratio of 1:5 at pH 7 by thermal denaturation assay2009Bioorganic & medicinal chemistry, Feb-15, Volume: 17, Issue:4
Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
AID54323Thermal stabilization of duplex form of calf thymus DNA after incubation for 0 hours2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID230366Resistance factor (IC50 resistant/ parent)2001Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
AID10018Growth inhibition in human ovarian carcinoma cell line (A2780cisR,cisplatin-resistant) using the 96 hour exposure sulforhodamine B (SRB) growth delay assay2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID94817Inhibitory concentration against human K562 leukemia cells following incubation for 1 hour2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID47514Inhibition of cell growth in human ovarian carcinoma cell line (CH1-cis-R,cisplatin resistant) using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID202838Inhibition of cell growth in human ovarian carcinoma cell line(SKOV-3) using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID232613Ratio of IC50 against human ovarian carcinoma cell line (CH1)cisR (cisplatin resistant) to the IC50 of parent2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID249980Increase in melting point temperature after 18 hr of incubation [1:5] as measurement of DNA binding affinity using calf thymus DNA2004Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
AID321352Cytotoxicity against human K562 cells2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
AID276048Induction of linear pBR322 DNA interstrand crosslinking2006Bioorganic & medicinal chemistry letters, Nov-01, Volume: 16, Issue:21
DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
AID270008Cytotoxicity against human NCI60 cell line by MTT assay2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
AID54325Thermal stabilization of duplex form of calf thymus DNA after incubation for 4 hours2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID321353Induction of cross linking in DS pUC18 plasmid2008Bioorganic & medicinal chemistry letters, Mar-15, Volume: 18, Issue:6
An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
AID10017Dose of required to inhibit growth of human ovarian carcinoma (A2780) cell line with compound free controls as measured by the sulforhodamine B growth delay assay2001Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
AID270012Cytotoxicity against human K562 cell line after 96 hrs by MTT assay2006Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
AID41578Compound was tested for inhibition of restriction endonuclease BamH1 enzyme at a concentration of 17.5 uM;Inhibited2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID225423The concentration of compound required for 50% cross linking of plasmid pBR322 DNA was investigated using an assay involving linear double stranded DNA2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID249982Increase in melting point temperature after 0h of incubation [1:5 ratio] as measurement of DNA binding affinity using calf thymus DNA2004Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22
Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential.
AID9821Inhibition of cell growth in human ovarian carcinoma cell line (A2780) using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID47512Inhibition of cell growth in human ovarian carcinoma cell line (CH1) was determined using the 96 hour continuous exposure sulforhodamine B (SRB) growth delay assay.2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID94467Inhibition of cell growth by 50% in human leukemia cell line (K562) was determined using microculture tetrazolium (MTT) assay.2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID232609Ratio of IC50 against A2780cisR (cisplatin resistant) to the IC50 of parent2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
AID10016Dose of required to inhibit growth of cisplatin resistant human ovarian carcinoma (A2780 cisR) cell line with compound free controls as measured by the sulforhodamine B growth delay assay2001Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
AID54324Thermal stabilization of duplex form of calf thymus DNA after incubation for 18 hours2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's27 (72.97)29.6817
2010's9 (24.32)24.3611
2020's1 (2.70)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.19 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (8.11%)5.53%
Reviews2 (5.41%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (86.49%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0210isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.0210aromatic ether;
nitrile;
polyether;
tertiary amino compound
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0310mitomycinalkylating agent;
antineoplastic agent
ornithine
Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.. ornithine : An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.		2.0310non-proteinogenic L-alpha-amino acid;
ornithine		algal metabolite;
hepatoprotective agent;
mouse metabolite
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		8.69303pyrrole;
secondary amine
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.		2.4320beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic
u 77779
bizelesin: structure given in first source		2.0210
bendamustine hydrochloride
[no description available]		3.1710
ecteinascidin 743
[no description available]		3.1710acetate ester;
azaspiro compound;
bridged compound;
hemiaminal;
isoquinoline alkaloid;
lactone;
organic heteropolycyclic compound;
organic sulfide;
oxaspiro compound;
polyphenol;
tertiary amino compound		alkylating agent;
angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
marine metabolite
talotrexin
N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine: RN refers to (S)-isomer		2.0310
c 1311
C 1311: an imidazoacridinone; arrests cell-cycle progression in the G2 phase of L1210 cells; structure given in first source		2.0310
melphalan
Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.		2.4220L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
fludarabine
[no description available]		2.4320purine nucleoside
anthramycin
[no description available]		2.0210
nsc 716970
centanamycin: a potent antimalarial and transmission-blocking DNA-binding agent inspired from ( )-duocarmycin SA that lacks a stereocenter; structure in first source. AS-I-145 : An indolecarboxamide obtained by the formal condensation of the carboxy group of 5,6,7-trimethoxyindole-2-carboxylic acid with the 2-amino group of 1-(2-chloroethyl)-2,4-diaminonaphthalene.		2.0310aromatic amine;
aromatic ether;
indolecarboxamide;
organochlorine compound		antineoplastic agent
dsb 120
[no description available]		3.1150
cc 1065
CC 1065: from Streptomyces zelensis; structure in second sourc		2.0310
gwl 78
[no description available]		2.0310
oligonucleotides
[no description available]		2.5120
ConditionIndicatedRelationship StrengthStudiesTrials
Canine Diseases
[description not available]		02.1110
Benign Neoplasms
[description not available]		06.4852
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		18.4852
Bladder Cancer
[description not available]		03.4411
Cancer of Colon
[description not available]		03.8321
Cancer of Lung
[description not available]		03.4411
Malignant Melanoma
[description not available]		03.4411
Cancer of Ovary
[description not available]		03.4411
Urinary Bladder Neoplasms
Tumors or cancer of the URINARY BLADDER.		03.4411
Colonic Neoplasms
Tumors or cancer of the COLON.		03.8321
Lung Neoplasms
Tumors or cancer of the LUNG.		03.4411
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		03.4411
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		03.4411
Breathlessness
[description not available]		03.4511
Anasarca
[description not available]		03.4511
Lassitude
[description not available]		03.4511
Dyspnea
Difficult or labored breathing.		03.4511
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		03.4511
Fatigue
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.		03.4511
B-Cell Chronic Lymphocytic Leukemia
[description not available]		02.4320
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.		14.4320
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0410
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