phenytoin and Fatigue studies

Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.

Research Excerpts

Excerpt	Relevance	Reference
"Valproic acid has become a regular component of antiepileptic therapy."	6.36	[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)
" When fluconazole, a potent inhibitor of CYP2C9, was added to the treatment regimen, the patient developed ataxia, tremor, fatigue, slurred speech and somnolence, indicating phenytoin intoxication."	3.76	Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. ( Bergman, U; Bertilsson, L; Engström Hellgren, K; Helldén, A; Masquelier, M; Nilsson Remahl, I; Odar-Cederlöf, I; Ramsjö, M, 2010)
"Gabapentin is an anticonvulsant drug that has analgesic properties for acute postoperative pain."	2.74	The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. ( Aykac, B; Bingol, CA; Karlikaya, G; Sayin, M; Türe, H; Türe, U, 2009)
"Valproic acid has become a regular component of antiepileptic therapy."	2.36	[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)

Research

Studies (16)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (75.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (6.25)	29.6817
2010's	2 (12.50)	24.3611
2020's	1 (6.25)	2.80

Authors	Studies
Vasudevan, V	1
Amatya, B	1
Khan, F	1
Akın, F	1
Kılıçaslan, C	1
Solak, ES	1
Uzun, M	1
Aygün, S	1
Arslan, Ş	1
Türe, H	1
Sayin, M	1
Karlikaya, G	1
Bingol, CA	1
Aykac, B	1
Türe, U	1
Helldén, A	1
Bergman, U	1
Engström Hellgren, K	1
Masquelier, M	1
Nilsson Remahl, I	1
Odar-Cederlöf, I	1
Ramsjö, M	1
Bertilsson, L	1
Fröscher, W	1
Schulz, HU	1
Gugler, R	1
Laitinen, L	1
Toivakka, E	1
Lund, L	1
Lundberg, PO	1
Stålberg, E	1
Thiele, B	1
Geering, JM	1
Ruch, W	1
Dettli, L	1
Eeg-Olofsson, O	1
Lehtovaara, R	1
Birket-Smith, E	1
Lund, M	1
Mikkelsen, B	1
Vestermark, S	1
Olsen, PZ	1
Holm, P	1
Ewy, GA	1
Marcus, FI	1
Fillmore, SJ	1
Matthews, NP	1
Malitz, S	1
Kanzler, M	1
Reinis, S	1
Richards, RN	1
Barnett, HJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Article	Year
Overview of systematic reviews: Management of common Traumatic Brain Injury-related complications. PloS one, 2022, Volume: 17, Issue:9 Topics: Brain Injuries, Traumatic; Fatigue; Humans; Levetiracetam; Phenytoin; Seizures; Systematic Reviews a	2022
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1978, Volume: 46, Issue:6 Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph	1978
Digitalis intoxication--diagnosis, management and prevention. Cardiovascular clinics, 1974, Volume: 6, Issue:2 Topics: Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Digitalis Glycosides; Digoxi	1974

Article	Year
The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesthesia and analgesia, 2009, Volume: 109, Issue:5 Topics: Administration, Oral; Adult; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid;	2009
A controlled trial on Ro 5-4023 (clonazepam) in the treatment of psychomotor epilepsy. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Carbamazepine; Child; Chlorobenzenes; Clinica	1973
Are antidepressants better than placebo? The American journal of psychiatry, 1971, Volume: 127, Issue:12 Topics: Adjustment Disorders; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Clinical Trials as	1971

Article	Year
Posterior reversible encephalopathy syndrome in children: report of three cases. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014, Volume: 30, Issue:3 Topics: Adolescent; Anticonvulsants; Antihypertensive Agents; Brain Stem; Cerebral Cortex; Child; Child, Pre	2014
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9. European journal of clinical pharmacology, 2010, Volume: 66, Issue:8 Topics: Alleles; Angiotensin II Type 1 Receptor Blockers; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; At	2010
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec	1973
Anticonvulsant effect of diphenylhydantoin relative to plasma levels. A prospective three-year study in ambulant patients with generalized epileptic seizures. Archives of neurology, 1974, Volume: 31, Issue:5 Topics: Adolescent; Adult; Aged; Ambulatory Care; Ataxia; Chromatography, Gas; Epilepsy; Epilepsy, Tonic-Clo	1974
Paralysis periodica paramyotonica. A clinical and neurophysiological study. Journal of the neurological sciences, 1974, Volume: 21, Issue:3 Topics: Acetazolamide; Acetylcholine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Calcium; Cre	1974
[Diphenylhydantoin poisoning due to diphenylhydantoin-isoniazid interaction]. Schweizerische medizinische Wochenschrift, 1974, Aug-31, Volume: 104, Issue:35 Topics: Adult; Cognition Disorders; Drug Interactions; Epilepsy; Fatigue; Humans; Isoniazid; Male; Middle Ag	1974
Experiences with Bivotril in treatment of epilepsy--particularly minor motor epilepsy--in mentally retarded children. Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlor	1973
A clinical trial with clonazepam (Ro 5-4023). Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53 Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepinones; Carbamazepine; Child; Chloroben	1973
Effect of hydroxylamine on maze learning in mice. Journal of comparative and physiological psychology, 1970, Volume: 72, Issue:3 Topics: Animals; Fatigue; Hydroxylamines; Injections; Memory; Methylene Blue; Mice; Nitrous Oxide; Phenytoin	1970
Paroxysmal dystonic choreoathetosis. A family study and review of the literature. Neurology, 1968, Volume: 18, Issue:5 Topics: Adult; Aged; Amobarbital; Athetosis; Atropine; Benzoates; Caffeine; Child, Preschool; Chorea; Coffee	1968

phenytoin and Fatigue