osimertinib profile

osimertinib: an EGFR tyrosine kinase inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

osimertinib : A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	71496458
CHEMBL ID	3353410
CHEBI ID	90943
SCHEMBL ID	14660911

Synonym
DUYJMQONPNNFPI-UHFFFAOYSA-N
n-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
osimertinib [inn]
azd9291 ,
1421373-65-0
osimertinib
osimertinib [mi]
3C06JJ0Z2O ,
osimertinib [usan]
2-propenamide, n-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-
mereletinib
azd-9291 free base
osimertinib [who-dd]
azd-9291
S7297
HY-15772
CS-2018
gtpl7719
azd 9291
n-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
mereletinib (obsolete inn)
mereletinib [inn]
unii-3c06jj0z2o
n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
osimertinibum
CHEBI:90943 ,
n-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide
AKOS025290756
SCHEMBL14660911
n-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4-(1-methyl-1h-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide
n-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
AC-29019
n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
DB09330
bdbm50029668
CHEMBL3353410
EX-A314
mfcd27988062
HMS3653E10
NCGC00378622-10
osimertinib; azd-9291
SW219863-1
mereletinibazd-9291,osimertinib
'osimertinib; azd 9291'
4714B
AS-16943
n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
BCP08626
Q21506464
n-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-2-propenamide
SB22952
HMS3672M05
AMY9161
CCG-264683
NCGC00378622-03
n(2{[2(dimethylamino)ethyl](methyl)amino}4methoxy5{[4(1methyl1hindol3yl)pyrimidin2yl]amino}phenyl)prop2enamide;osimertinib
A854509
nsc-800812
nsc800812
nsc779217
nsc-781254
nsc781254
nsc-779217
NCGC00378622-04
osimertinib (azd9291)
DTXSID501025961
n-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)prop-2-enamide
l01xe35
2-propenamide, n-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-; n-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;
EN300-7382438

Excerpt	Reference	Relevance
"Osimertinib is a highly potent and selective third-generation epidermal growth factor receptor (EGFR) inhibitor, which provides excellent clinical benefits and is now a standard-of-care therapy for advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC). "	( Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. Chang, J; Du, J; Huang, H; Li, E; Meng, Y; Peng, Y; Song, C; Wang, K; Yao, Y; Yi, D; Yu, B; Yu, W; Zhu, K, 2021)	2.42
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used to treat non-small cell lung cancer. "	( Systematic analysis of the potential off-target activities of osimertinib by computational target fishing. Bi, YH; Chen, SJ; Zhang, LH, 2022)	2.4
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved as first-line therapy for advanced "	( Transient asymptomatic pulmonary opacities and interstitial lung disease in Ardizzoni, A; Bordi, P; Brocchi, S; Buti, S; Golfieri, R; Gustavo Dall'Olio, F; Leonetti, A; Parisi, C; Rizzo, A; Sverzellati, N; Taronna, G; Tiseo, M, 2022)	2.16
"Osimertinib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor. "	( Elevated serum creatine kinase levels due to osimertinib: A case report and review of the literature. Matsumoto, S; Sugimoto, H; Sugimoto, K; Tsuji, Y, 2022)	2.42
"Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for lung adenocarcinoma (LUAD) harboring activating mutations, but patients ultimately develop acquired resistance. "	( Hsa_circ_0005576 promotes osimertinib resistance through the miR-512-5p/IGF1R axis in lung adenocarcinoma cells. Chai, Y; Chen, Y; Feng, W; He, W; Jiang, Z; Jin, L; Li, X; Liu, S; Liu, Y; Ma, Y; Tang, H; Xiao, P; Xie, Q; Zhu, Z, 2022)	2.46
"Osimertinib (TAGRISSO®) is a medication used to treat a type of NSCLC with a change (mutation) in the EGFR gene, known as EGFR-mutated NSCLC."	( A plain language summary of results from the ADAURA study: osimertinib after surgery for patients who have early-stage EGFR-mutated non-small cell lung cancer. Akewanlop, C; Atasoy, A; Bonanno, L; de Marinis, F; Domine, M; Goldman, JW; Grohe, C; Herbst, RS; Hodge, R; John, T; Kato, T; Kim, SW; Laktionov, K; Lee, KY; Lu, S; Majem, M; Rukazenkov, Y; Shepherd, FA; Tsuboi, M; Vu, HV; Wu, YL; Yu, CJ; Zeng, L, 2021)	1.59
"Osimertinib (OB) is a third-generation irreversible tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR), overexpressed in non-small cell lung cancer. "	( Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation. Gupta, V; Kulkarni, NS; Kunda, NK; Patil, SM; Sawant, SS; Shukla, SK, 2022)	2.48
"Osimertinib is a standard of care therapy for previously untreated epidermal growth factor receptor mutation-positive non-small cell lung cancer. "	( First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002). Asahina, H; Dosaka-Akita, H; Fujita, Y; Harada, T; Hommura, F; Honda, R; Honjo, O; Ikezawa, Y; Isobe, H; Ito, K; Kikuchi, H; Kimura, N; Morita, R; Nakamura, A; Oizumi, S; Sasaki, T; Sukoh, N; Sumi, T; Takashina, T; Tanaka, H; Yamamoto, G; Yokoo, K, 2021)	2.45
"Osimertinib is a promising option for NSCLC with LM harboring epidermal growth factor receptor (EGFR) mutation."	( Erlotinib combined with bevacizumab and chemotherapy in first line osimertinib-resistant NSCLC patient with leptomeningeal metastasis: A case report. Li, M; Luo, N; Qi, Y; Wang, M; Zhu, F, 2021)	1.58
"Osimertinib is a standard first-line treatment for non-small cell lung cancer (NSCLC) harboring mutations of the epidermal growth factor receptor gene (EGFR). "	( Phase III Clinical Trial for the Combination of Erlotinib Plus Ramucirumab Compared With Osimertinib in Previously Untreated Advanced or Recurrent Non-Small Cell Lung Cancer Positive for the L858R Mutation of EGFR: REVOL858R (WJOG14420L). Azuma, K; Haratake, N; Hayashi, H; Nakagawa, K; Nakano, Y; Oki, M; Ota, K; Sakamoto, T; Seto, T; Shimokawa, M; Yamamoto, N; Yoshioka, H, 2022)	2.39
"Osimertinib is a potent third-generation EGFR tyrosine kinase inhibitor with confirmed CNS penetration."	( Standard-Dose Osimertinib in EGFR-Mutated Non-Small-Cell Lung Adenocarcinoma With Leptomeningeal Disease. Broad, AR; Chin, MT; Faisal, W; Itchins, MJ; Jennens, RR; Kao, SC; Lewis, CR; McLean, LS; Morris, TA; Parakh, S; Solomon, BJ; Voskoboynik, M, 2021)	1.7
"Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR) used for the treatment of non-small cell lung cancer (NSCLC) presenting an EGFR mutation. "	( Osimertinib induced cardiac failure and QT-prolongation in a patient with advanced pulmonary adenocarcinoma. Bardaro, F; Stirpe, E, 2022)	3.61
"Osimertinib is an approved therapy for patients with a Thr790met (T790M) mutation diagnosed with non-small cell lung cancer (NSCLC) that progresses during epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy. "	( Successful desensitization under antihistamine suppression in a case with urticaria due to osimertinib. Aksu, K; Ateş, H; Çuhadar Erçelebi, D; Demir, Ş; Koca Kalkan, İ; Köycü Buhari, G; Nazik Bahçecioğlu, S; Topel, M; Vural Solak, GT; Yeşilkaya, S, 2022)	2.38
"Osimertinib is a tyrosine kinase inhibitor approved as first-line therapy in patients with metastatic NSCLC harboring exon 19 or exon 21 EGFR mutations."	( Osimertinib-induced syndrome of inappropriate secretion of antidiuretic hormone in oncogene-addicted lung adenocarcinoma: A case report. Bozoky, B; Skribek, M; Tsakonas, G, 2022)	2.89
"Osimertinib is a third-generation, irreversible, CNS penetrant, oral EGFR TKI that demonstrates promising efficacy in CNS metastases regardless of T790M."	( Osimertinib Combined with Systemic Chemotherapy for EGFR Mutant, T790M-Negative, Non-Small Cell Lung Cancer Patients Who Develop Leptomeningeal Metastases with Extracranial Progression to Prior EGFR TKI. Ahn, JS; Ahn, MJ; Hong, J; Jo, H; Jung, HA; Kim, H; Kim, HR; Lee, SH; Park, S, 2023)	3.07
"Osimertinib is a standard first-line treatment for advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. "	( Efficacy of osimertinib in epidermal growth factor receptor-mutated non-small-cell lung cancer patients with pleural effusion. Kondo, K; Mitsuhashi, A; Nishioka, Y; Nokihara, H; Ogawa, E; Ogino, H; Otsuka, K; Ozaki, R; Yabuki, Y; Yoneda, H, 2022)	2.54
"Osimertinib is a third generation EGFR-TKI inhibitor approved in the first-line setting for patients with advanced non-small cell lung cancer (NSCLC). "	( Mechanisms of Resistance to First-Line Osimertinib in Hispanic Patients With EGFR Mutant Non-Small Cell Lung Cancer (FRESTON-CLICaP). Archila, P; Arrieta, O; Bermudez, M; Blaquier, JB; Burotto, M; Cardona, AF; Carranza, H; Chamorro, DF; Cordeiro de Lima, V; Corrales, L; Cuello, M; Enrico, D; Freitas, H; Gamez, T; Garcia-Robledo, JE; Jaller, E; Malapelle, U; Martín, C; Más, L; Mejía, S; Minata, JN; Ordóñez-Reyes, C; Otero, J; Perez, DM; Polo, C; Raez, L; Recondo, G; Ricaurte, L; Rodríguez, J; Rolfo, C; Rosell, R; Ruiz-Patiño, A; Russo, A; Samtani, S; Santoyo, N; Sotelo, C; Vargas, C; Viola, L; Zatarain-Barrón, ZL, 2022)	2.43
"Osimertinib (AZD9291) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), used for treating patients with advanced non-small-cell lung cancer (NSCLC) harboring EGFR-activating mutations or the resistant T790M mutation. "	( P21-activated kinase 2-mediated β-catenin signaling promotes cancer stemness and osimertinib resistance in EGFR-mutant non-small-cell lung cancer. Chen, D; Deng, J; Fan, S; He, Z; Huang, Y; Li, P; Liu, H; Luo, K; Lv, X; Wang, J; Yang, M; Yi, Y; Zeng, S, 2022)	2.39
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effective against the EGFR T790M mutation in patients with advanced non-small-cell lung cancer (NSCLC). "	( Anti-EGF nanobodies enhance the antitumoral effect of osimertinib and overcome resistance in non-small cell lung cancer (NSCLC) cellular models. Codony-Servat, J; Giralt, E; Guardiola, S; Rosell, R; Sánchez-Navarro, M, 2022)	2.41
"Osimertinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) used in first line for the treatment of advanced EGFR-mutated non-small cell lung cancer (NSCLC)."	( Histomolecular Resistance Mechanisms to First-Line Osimertinib in EGFR-Mutated Advanced Non-Small Cell Lung Cancer: A Multicentric Retrospective French Study. Akli, A; Duchemann, B; Dujon, C; Fallet, V; Friard, S; Girard, N; Giroux-Leprieur, E; Gounant, V; Rousseau-Bussac, G; Trédaniel, J; Wislez, M, 2022)	2.42
"Osimertinib is a third-generation tyrosine kinase inhibitor for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR)-sensitizing mutations and acquired drug-resistant mutation T790M. "	( Reuse of osimertinib after small cell lung cancer transformation in lung adenocarcinoma with de-novo epidermal growth factor receptor T790M mutation: case report. Li, L; Liang, J; Pan, Z; Wang, L; Wang, X, 2023)	2.77
"Osimertinib is a recently approved third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR-T790M resistance mutations. "	( Efficacy and safety of osimertinib for patients with EGFR-mutated NSCLC: a systematic review and meta-analysis of randomized controlled studies. Deng, J; Huang, Q; Li, L; Li, Z; Liu, L; Sun, J; Wei, W; Yan, F, 2022)	2.47
"Osimertinib is an effective therapy for NSCLC patients with acquired resistance due to T790M mutation after first- and second-generation EGFR-TKI treatment."	( Sequential treatment in advanced non-small cell lung cancer harboring EGFR mutations. Chang, CF; Chang, JW; Fang, YF; Hsu, PC; Huang, CY; Kuo, CS; Wu, CE; Yang, CT, )	0.85
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that has shown marked antitumor activity in patients with EGFR-mutated non-small-cell lung cancer (NSCLC). "	( Notch pathway regulates osimertinib drug-tolerant persistence in EGFR-mutated non-small-cell lung cancer. Furuta, M; Hatanaka, KC; Hatanaka, Y; Kikuchi, E; Kikuchi, J; Konno, S; Morinaga, D; Noguchi, T; Sakakibara-Konishi, J; Shinagawa, N; Shoji, T; Takahashi, H; Tsuji, K, 2023)	2.66
"Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) indicated for the treatment of epidermal growth factor receptor mutated non-small cell lung cancer (NSCLC). "	( Possible heart failure caused by osimertinib in a lung cancer patient. Alvarez, R; Collado-Borrell, R; Escudero-Vilaplana, V; Herranz, A; Narrillos-Moraza, Á; Ruiz-Briones, P; Sanjurjo, M; Vicente-Valor, J; Villanueva-Bueno, C, 2023)	2.63
"Osimertinib is a potent irreversible third-generation EGFR-TKI targeting EGFR mutations but has little effect on wild-type EGFR."	( Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance. Fu, K; Fu, L; Wang, F; Xie, F, 2022)	1.67
"Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) capable of overcoming non-small cell lung cancer (NSCLC) with EGFR T790M mutation. "	( [Efficacy of Osimertinib Combined with Bevacizumab in Advanced Non-small Cell  Lung Cancer Patients with Acquired EGFR T790M Mutation]. Gu, Y; Li, X; Li, Y; Nong, J; Qian, K; Tian, X; Wang, R, 2022)	2.53
"Osimertinib is a highly selective third-generation irreversible inhibitor of epidermal growth factor receptor mutant, which can be utilized to treat non-small cell lung cancer. "	( Metabolism and pharmacokinetic study of deuterated osimertinib. Bao, S; Chen, X; Dahar, MR; Ji, K; Li, X; Lin, N; Niu, C; Tang, Z; Wu, Y; Yu, L; Zeng, K; Zhan, X; Zhou, S, 2023)	2.6
"Osimertinib, which is an irreversible third-generation EGFR TKI, was designed for EGFR -activating mutations as well as the EGFR T790M mutation in patients with advanced NSCLC and has demonstrated a convincing efficacy."	( Acquired EML4-ALK fusion and EGFR C797S in cis mutation as resistance mechanisms to osimertinib in a non-small cell lung cancer patient with EGFR L858R/T790M. Chen, SQ; Duan, XP; Jiao, XD; Ling, Y; Liu, K; Qin, BD; Wang, LS; Wu, Y; Zang, YS; Zhong, X, 2023)	1.86
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is an established standard treatment option for chemotherapy-naive patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). "	( A phase II study (WJOG12819L) to assess the efficacy of osimertinib in patients with EGFR mutation-positive NSCLC in whom systemic disease (T790M-negative) progressed after treatment with first- or second-generation EGFR TKIs and platinum-based chemothera Azuma, K; Fujimoto, D; Hasegawa, K; Hayakawa, D; Hayashi, H; Iwama, E; Kato, T; Nakagawa, K; Nakamura, A; Nosaki, K; Oki, M; Shimokawa, M; Tachihara, M; Takahashi, T; Takeda, M; Tanaka, H; Watanabe, Y; Yamaguchi, K; Yamamoto, N; Yamamoto, S, 2023)	2.6
"Osimertinib is a third-generation, irreversible, EGFR-tyrosine kinase inhibitor that potently and selectively inhibits EGFR-sensitizing and T790M resistance mutations with efficacy in EGFRm NSCLC including central nervous system (CNS) metastases."	( Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non-small cell lung cancer and brain metastases: A positron emission tomography and magnetic resonance imaging study. Brown, AP; Cselényi, Z; Ekman, S; Farde, L; Johnström, P; Jucaite, A; Laus, G; Lewensohn, R; Martin, H; Schou, M; van der Aart, J; Varrone, A; Vishwanathan, K, 2023)	1.97
"Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR-TKI sensitizing and EGFR T790M resistance mutations, with demonstrated efficacy in EGFR mutation-positive (EGFRm) non-small cell lung cancer (NSCLC), including central nervous system (CNS) metastases. "	( Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA2. Chen, A; Dacic, S; Goldman, JW; He, J; Huang, X; Majem, M; Tsutani, Y; van der Gronde, T; Yatabe, Y, 2023)	2.77
"Osimertinib is a third-generation, irreversible, oral EGFR tyrosine kinase inhibitor (TKI) recommended as first-line treatment for patients with locally advanced/metastatic EGFR mutation-positive (EGFRm) non-small cell lung cancer (NSCLC). "	( Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model. Bao, L; Jones, RDO; Petersson, K; Schuller, AG; Tabatabai, A; Tomkinson, H, 2023)	2.59
"Osimertinib mesylate is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor used to treat nonsmall-cell lung cancer. "	( Insight into Chavan, BB; Dhiman, V; Ramarapu, N; Samanthula, G, 2023)	2.35
"Osimertinib is an EGFR tyrosine kinase inhibitor (TKI) with proven clinical efficacy; however, acquired resistance presents an obstacle to curing "	( Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells. Criscione, S; Delpuech, O; Floc'h, N; Gagrica, S; Martin, MJ; McDermott, U; Pfeifer, M; Smith, PD; Yao, Y, 2022)	2.39
"Osimertinib is a key drug for treating epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). "	( Association of Hori, T; Ikushima, S; Ito, T; Konishi, T; Nishiguchi, H; Omura, T; Ozaki, T; Shimizu, M; Tachihara, M; Tanda, M; Yagi, M; Yamamoto, K; Yano, I; Yoshioka, N, 2023)	2.35
"Osimertinib (AZD9291) is an irreversible third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used to treat stage IV EGFR-mutated non-small-cell lung cancer."	( Acquired resistance mechanisms to osimertinib: The constant battle. Catherine Rita Hachem, M; Eid, R; Hachem, S; Kassis, Y; Planchard, D; Raphael Kourie, H; Zalaquett, Z, 2023)	1.91
"Osimertinib resistance is an unmet clinical need for the treatment of non-small cell lung cancer (NSCLC), and the main mechanism is tertiary C797S mutation of epidermal growth factor receptor (EGFR). "	( Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. Cai, Z; Chen, W; Dong, H; Ji, M; Shen, H; Sun, H; Wang, K; Xiao, Y; Yang, P; Ye, X; Zheng, M; Zhu, Y, 2023)	2.57
"Osimertinib monotherapy is a common treatment for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC); however, standard treatment strategies for acquired resistance to this drug have not been established. "	( Clinical Efficacy and Safety of First- or Second-Generation EGFR-TKIs after Osimertinib Resistance for EGFR Mutated Lung Cancer: A Prospective Exploratory Study. Chihara, Y; Date, K; Goto, Y; Iwasaku, M; Kanda, H; Katayama, Y; Kunimatsu, Y; Morimoto, K; Shiotsu, S; Takayama, K; Takeda, T; Tamiya, N; Tokuda, S; Yamada, T, 2023)	2.58
"Osimertinib is a third‑generation EGFR‑tyrosine kinase inhibitor, which can improve the efficacy and quality of life of patients; however, the inevitable resistance after long‑term use of osimertinib often leads to treatment failure."	( Characterization of circRNAs in established osimertinib‑resistant non‑small cell lung cancer cell lines. Chen, X; Chen, Z; Gu, J; Huang, J; Wang, Z; Wen, K; Zhang, G, 2023)	1.89
"Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that is selective for EGFR-TKI-sensitizing and "	( Osimertinib with or without Chemotherapy in Ahmed, S; Andrasina, I; Cheng, Y; Fan, Y; Geater, SL; Ghiorghiu, D; Goldman, J; Jänne, PA; Kim, SW; Kobayashi, K; Laktionov, K; Lee, CK; Maurel, JM; Planchard, D; Rukazenkov, Y; Sugawara, S; Todd, A; Valdiviezo, N; Yanagitani, N; Yang, JC; Yu, Y, 2023)	3.8
"Osimertinib is a key drug for cancer patients with EGFR mutations. "	( Osimertinib in a patient with non-small cell lung cancer and renal failure undergoing hemodialysis: a case report. Fujimoto, D; Fukushima, S; Hosoya, K; Irie, K; Matsunashi, A; Tomii, K, 2020)	3.44
"Osimertinib is a new third-generation, epidermal growth factor receptor-tyrosine kinase inhibitor highly selective for the epidermal growth factor receptor with both activating and T790M mutations. "	( Acquired BRAF G469A Mutation as a Resistance Mechanism to First-Line Osimertinib Treatment in NSCLC Cell Lines Harboring an EGFR Exon 19 Deletion. Alfieri, R; Bonelli, M; Cavazzoni, A; Cretella, D; Digiacomo, G; Fumarola, C; Galetti, M; La Monica, S; Minari, R; Petronini, PG; Riccardi, F; Tiseo, M, 2019)	2.19
"Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor against T790M-mutant non-small cell lung cancer (NSCLC). "	( Applied electric fields suppress osimertinib-induced cytotoxicity via inhibiting FOXO3a nuclear translocation through AKT activation. A, C; Cheng, C; Han, R; He, Y; Hu, C; Li, L; Lin, C; Lu, C; Zhang, K; Zhao, M; Zhao, S, 2020)	2.28
"Osimertinib is a "third-generation'' oral, irreversible, tyrosine kinase inhibitor. "	( Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry. Beijnen, JH; Rood, JJM; Sparidans, RW; van Haren, MJ, 2020)	2.29
"Osimertinib is an irreversible, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that is highly selective for EGFR-activating mutations as well as the EGFR T790M mutation in patients with advanced non-small cell lung cancer (NSCLC) with EGFR oncogene addiction. "	( Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer. Giovannetti, E; Leonetti, A; Minari, R; Perego, P; Sharma, S; Tiseo, M, 2019)	2.26
"Osimertinib is a third-generation, irreversible tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and "	( Overall Survival with Osimertinib in Untreated, Cheema, P; Cheng, Y; Chewaskulyong, B; Cho, BC; Cobo, M; Gray, JE; Hodge, R; Imamura, F; John, T; Kurata, T; Lee, KH; Lin, MC; Ohe, Y; Planchard, D; Ramalingam, SS; Reungwetwattana, T; Rukazenkov, Y; Saggese, M; Shah, R; Soria, JC; Tiseo, M; Todd, A; Vansteenkiste, J; Zhou, C, 2020)	2.32
"Osimertinib (AZD9291) is a third-generation EGFR-tyrosine kinase inhibitor (TKI) that selectively inhibits the activating EGFR mutation and T790M mutation, and is currently used globally to treat EGFR-mutant non-small cell lung cancer (NSCLC). "	( Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. Asao, T; Hayakawa, D; Hayashi, T; Hidayat, M; Ihara, H; Kanamori, K; Ko, R; Kohsaka, S; Mano, H; Matsumoto, N; Mitsuishi, Y; Shukuya, T; Suehara, Y; Tajima, K; Takahashi, F; Takahashi, K; Takamochi, K; Takeda Nakamura, I; Ueno, T; Winardi, W, 2020)	2.23
"Osimertinib is an oral, irreversible epidermal growth factor receptor inhibitor that is associated with various pulmonary manifestations including transient asymptomatic pulmonary opacities (TAPOs) and pneumonitis. "	( Osimertinib in Pulmonary Manifestations: Two Case Reports and Review of the Literature. Dowell, J; Lu, H, )	3.02
"Osimertinib is a potent, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). "	( TATTON: a multi-arm, phase Ib trial of osimertinib combined with selumetinib, savolitinib, or durvalumab in EGFR-mutant lung cancer. Ahn, MJ; Frigault, MM; Ghiorghiu, D; Goto, K; Horn, L; Kim, SW; Mann, H; Ohe, Y; Oxnard, GR; Ramalingam, SS; Saka, H; Thress, KS; Vishwanathan, K; Yang, JC; Yu, H, 2020)	2.27
"Osimertinib is a third-generation, irreversible tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR-TKI) showing longer progression free survival and overall survival than other EGFR-TKI with an improvement in tolerability."	( Aplastic anemia in a patient with advanced lung adenocarcinoma during first line osimertinib: A case report and literature review. Alberti, A; Bidoli, P; Cortinovis, D; Mancin, M; Pastore, A; Sala, L; Seminati, D, 2020)	2.23
"Osimertinib mesylate is a mutant epidermal growth factor receptor (EGFR) inhibitor that can penetrate the blood-brain barrier and inhibit tumor cell survival and proliferation in patients with non-small cell lung cancer (NSCLC) with specific EGFR alterations."	( Assessment of Effectiveness and Safety of Osimertinib for Patients With Intracranial Metastatic Disease: A Systematic Review and Meta-analysis. Brastianos, PK; Das, S; Erickson, AW, 2020)	1.54
"Osimertinib, which is a third-generation EGFR-TKI, has a clinical effect even on NSCLC harboring the threonine to methionine change at codon 790 of EGFR (EGFR T790M) mutation that causes TKI resistance."	( Efficacy of immunotherapy targeting the neoantigen derived from epidermal growth factor receptor T790M/C797S mutation in non-small cell lung cancer. Akazawa, Y; Mizuno, S; Nakamoto, Y; Nakatsura, T; Nosaka, K; Saito, K; Saito, Y; Shimomura, M; Yoshikawa, T, 2020)	1.28
"Osimertinib is a molecularly targeted agent used to treat non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) T790M mutation. "	( Osimertinib for patients with poor performance status and EGFR T790M mutation-positive advanced non-small cell lung cancer: a phase II clinical trial. Akamatsu, H; Daga, H; Imai, H; Kawamura, T; Mori, K; Murakami, H; Nakashima, K; Ozawa, Y; Takahashi, T; Tamiya, M; Tokito, T; Tsuboguchi, Y; Yamamoto, N, 2020)	3.44
"Osimertinib is a third-generation "	( Reduced sensitivity for Harraway, J; Jones, V; Lee, E; Topkas, E, 2021)	2.06
"Osimertinib is a standard therapy for advanced non-small cell lung cancer (NSCLC) patients with an acquired epidermal growth factor receptor (EGFR) T790M mutation; however, the exploration of clinical characteristics that may affect prognosis and long-term survival is still lacking."	( Clinical Factors Affecting the Response to Osimertinib in Non-Small Cell Lung Cancer Patients with An Acquired Epidermal Growth Factor Receptor T790M Mutation: A Long-Term Survival Analysis. Chen, Y; Han, B; Hu, M; Wang, S; Zhang, B; Zhang, L; Zhang, W; Zhao, Y, 2020)	2.26
"Osimertinib is a new treatment option that demonstrated a superior efficacy over standard epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or platinum-based chemotherapy."	( A review of Osimertinib in NSCLC and pharmacist role in NSCLC patient care. Al-Quteimat, OM; Amer, AM, 2020)	1.66
"Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR-TKI sensitizing and EGFR T790M and has demonstrated efficacy in non-small cell lung cancer (NSCLC) central nervous system metastases. "	( A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment. de Miguel-Luken, M; Johnson, M; Keam, B; Marotti, M; Mills, A; Penel, N; Ravaud, A; Sanchez-Simon, I; Vishwanathan, K; Weilert, D, 2020)	2.26
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that potently and selectively inhibits EGFR activating and EGFR T790M resistance mutations. "	( Prospective Observational Study of Treatment Resistance-related Gene Screening Using Plasma Circulating Tumor DNA in Third-generation EGFR-TKI Osimertinib Therapy (Elucidator). Ando, M; Atagi, S; Isa, SI; Koh, Y; Nakagawa, H; Tamiya, A; Taniguchi, Y, 2021)	2.26
"Osimertinib is a promising treatment option for EGFR-mutated NSCLC with LM regardless of T790M mutational status."	( Osimertinib Improves Overall Survival in Patients With EGFR-Mutated NSCLC With Leptomeningeal Metastases Regardless of T790M Mutational Status. Ahn, JS; Ahn, MJ; Choi, Y; Han, J; Jung, HA; Lee, J; Lee, SH; Park, K; Park, S; Su, JM, 2020)	3.44
"Osimertinib is an irreversible EGFR-tyrosine kinase inhibitor initially approved for treatment of EGFR-positive patients exhibiting a T790 M resistance mutation in the second line setting and now emerging as the new standard of care for all EGFR positive patients as first-line treatment. "	( Mechanisms of osimertinib resistance and emerging treatment options. Leighl, NB; Li, JJN; Schmid, S, 2020)	2.36
"Osimertinib is a third-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has demonstrated efficacy in the treatment of EGFR-mutant non-small-cell lung cancer (NSCLC) in prospective clinical trials."	( Effectiveness of osimertinib in patients with lung adenocarcinoma in clinical practice - the Expanded Drug Access Program in Poland. Bryl, M; Czyżewicz, G; Dziadziuszko, R; Kieszko, R; Knetki-Wróblewska, M; Kowalski, DM; Krzakowski, M; Milanowski, J; Ramlau, R; Świniuch, D; Wrona, A, 2020)	2.34
"Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and "	( Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I. Ahmed, A; Bickerton, S; Cho, BC; Cross, DAE; Floc'h, N; Lim, S; Martin, MJ; Orme, J; Smith, PD; Urosevic, J, 2020)	3.44
"Osimertinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body."	( Osimertinib for EGFR-mutant lung cancer with central nervous system metastases: a meta-analysis and systematic review. Chen, G; Cui, S; Deng, H; Mao, J; Mi, Y; Tang, Z; Wang, L; Wang, N; Zhang, Y, 2020)	2.72
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that has exhibited efficacy in patients with EGFR-mutant non-small cell lung cancer (NSCLC). "	( Retrospective analysis of osimertinib re-challenge after osimertinib-induced interstitial lung disease in patients with EGFR-mutant non-small cell lung carcinoma. Endo, M; Kawamura, T; Kenmotsu, H; Kobayashi, H; Kodama, H; Mamesaya, N; Miyawaki, E; Miyawaki, T; Murakami, H; Naito, T; Nishioka, N; Omori, S; Ono, A; Takahashi, T; Wakuda, K; Yabe, M, 2021)	2.36
"Osimertinib is a potent, irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for both EGFR-activating and T790M resistant mutation. "	( A Phase II Trial of Osimertinib as the First-Line Treatment of Non-Small Cell Lung Cancer Harboring Activating EGFR Mutations in Circulating Tumor DNA: LiquidLung-O-Cohort 1. Cho, HJ; Choi, YD; Kim, YC; Oh, IJ; Park, CK, 2021)	2.39
"Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of both sensitizing and T790M resistance mutations. "	( Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs. Adua, SJ; Arakawa, R; Atkinson, J; Barton, P; Chen, K; Cheng, Z; Colclough, N; Cross, DAE; Farde, L; Finlay, MRV; Goodwin, R; Janefeldt, A; Johnström, P; Karp, NA; Kondrashov, M; Maglennon, G; Malmquist, J; Moein, MM; Nguyen, DX; Revunov, E; Schou, M; Smith, A; Smith, PD; Strittmatter, N; Takano, A; Varnäs, K; Vazquez-Romero, A; Ward, RA; Wilson, J; Windhorst, AD; Wrigley, GL; Yan, Y; Yates, JWT; Zhang, L; Zhao, M, 2021)	2.3
"Osimertinib is a TKI that was fast-tracked by the United States Food and Drug Administration in 2015 and subsequently approved for the treatment of metastatic epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer."	( Myositis - A common but underreported adverse effect of osimertinib: Case series and review of the literature. Beutler, BD; Islam, RX; Krishan, R; Parafianowicz, P; Singh, T, 2020)	1.53
"Osimertinib is a third-generation, CNS-active, irreversible, oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that potently and selectively inhibits both EGFR-TKI-sensitizing and T790M resistance mutations. "	( Cardiac Safety of Osimertinib: A Review of Data. Atuah, KN; Ewer, MS; Tekumalla, SH; Walding, A, 2021)	2.4
"Osimertinib, which is an irreversible third-generation EGFR TKI, has demonstrated a convincing efficacy, irrespective of whether it is used in first- or second-line treatment."	( ALK rearrangements as mechanisms of acquired resistance to osimertinib in EGFR mutant non-small cell lung cancer. Hou, H; Liu, D; Sun, D; Zhang, C; Zhang, X, 2021)	1.59
"Osimertinib is a third-generation EGFR tyrosine kinase inhibitor that has improved survival and central nervous system (CNS) outcomes in patients with non-small cell lung cancer (NSCLC) with activating EGFR mutations. "	( Combining Osimertinib With Chemotherapy in EGFR-Mutant NSCLC at Progression. Banwait, MK; Cunanan, K; Hausrath, D; Liu, SV; Neal, JW; Piotrowska, Z; Sequist, LV; Stirling, K; Wakelee, HA; White, MN, 2021)	2.47
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that has recently been established as a standard treatment option for chemotherapy-naive patients with EGFR mutation-positive non-small-cell lung cancer (NSCLC). "	( A Phase II Study to Assess the Efficacy of Osimertinib in Patients With EGFR Mutation-positive NSCLC Who Developed Isolated CNS Progression (T790M-negative or Unknown) During First- or Second-generation EGFR-TKI or Systemic Disease Progression (T790M-nega Azuma, K; Fujimoto, D; Hamaguchi, N; Hasegawa, K; Hayakawa, D; Kato, T; Kogure, Y; Nakagawa, K; Nakamura, A; Nosaki, K; Okamoto, I; Shimokawa, M; Tachihara, M; Takahashi, T; Takeda, M; Tanaka, H; Watanabe, Y; Yamaguchi, K; Yamamoto, N, 2021)	2.33
"Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) used both as the first-line treatment of EGFR-mutated non-small cell lung cancer patients and in second-line after T790M-positive disease progression to first- or second-generation TKIs. "	( Afatinib therapy in case of EGFR G724S emergence as resistance mechanism to osimertinib. Alfieri, R; Bottarelli, L; Gnetti, L; La Monica, S; Lagrasta, C; Leonetti, A; Minari, R; Petronini, PG; Tiseo, M; Ventura, L; Zielli, T, 2021)	2.29
"Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that is effective in treating both naïve and T790M-mutated EGFR-TKI-resistant non-small cell lung cancer patients. "	( Monitoring epidermal growth factor receptor C797S mutation in Japanese non-small cell lung cancer patients with serial cell-free DNA evaluation using digital droplet PCR. Ariyasu, R; Fujita, N; Ishikawa, Y; Katayama, R; Kitazono, S; Kiyotani, K; Mizukami, Y; Ninomiya, H; Nishio, M; Ono, Y; Sasaki, T; Tsukahara, M; Uchibori, K; Yanagitani, N; Yoshida, R, 2021)	2.06
"Osimertinib is an epidermal growth factor receptor-tyrosine kinase inhibitor that specifically targets the T790M mutation in cancer.Unfortunately, most non-small cell lung cancer (NSCLC) patients develop osimertinib resistance. "	( Exosomal microRNAs as potential biomarkers for osimertinib resistance of non-small cell lung cancer patients. Chairoungdua, A; Janpipatkul, K; Metheetrairut, C; Oranratnachai, S; Panvongsa, W; Reungwetwattana, T; Trachu, N; Watcharenwong, P; Worakitchanon, W, 2021)	2.32
"Osimertinib is a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). "	( Exosome-derived miR-210 involved in resistance to osimertinib and epithelial-mesenchymal transition in EGFR mutant non-small cell lung cancer cells. Gemma, A; Hisakane, K; Matsuda, K; Noro, R; Seike, M; Sugano, T; Takahashi, S; Takano, N; Yoshikawa, A, 2021)	2.32
"Osimertinib is a third generation tyrosine kinase inhibitor (TKI) that targets the epidermal growth factor receptor (EGFR) in lung cancer. "	( Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment. Bostoën, M; Chaillot, L; Gournay, M; Guillaudeux, T; Jarry, U; Le Goff, A; Mennessier, V; Montagne, P; Motte, E; Pedeux, R; Pineau, R, 2021)	2.28
"Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor."	( OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs. Halatsch, ME; Kast, RE; Rosell, R, 2021)	1.71
"Osimertinib is a third-generation EGFR-tyrosine kinase inhibitor that is efficacious against EGFR-sensitizing mutations."	( Nasogastric administration of osimertinib suspension for an epidermal growth factor receptor-mutated lung cancer causing an esophageal stricture: case report. Kataoka, N; Kato, D; Kunimatsu, Y; Nakano, T; Sato, I; Takatsuka, S; Takeda, T; Tani, N; Tanimura, K; Tanimura, M; Tsutsumi, R, 2022)	1.73
"Osimertinib is a third-generation, irreversible oral EGFR-tyrosine kinase inhibitor), that potently inhibits EGFR-tyrosine kinase inhibitor-sensitizing mutations and T790M resistance mutations together with efficacy in CNS metastases in patients with non-small-cell lung cancer (NSCLC). "	( Neoadjuvant osimertinib with/without chemotherapy versus chemotherapy alone for Blakely, C; Chaft, JE; Dacic, S; Escriu, C; He, J; Tsuboi, M; Walding, A; Weder, W; Yatabe, Y; Zeng, L, 2021)	2.44
"Osimertinib is a highly effective option in second- or third-line treatment of NSCLC patients with T790M mutation, with a favorable safety profile."	( The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study. Açıkgöz, Ö; Ak, N; Aydıner, A; Ayhan, M; Bahçeci, A; Başoğlu, T; Bilgin, B; Bilici, A; Can, A; Caner, B; Demiray, AG; Demirkazık, A; Demirkıran, A; Erol, C; Gökmen, İ; Gülmez, A; Gürbüz, M; Güven, DC; Hizal, M; İriağaç, Y; Karakaş, Y; Mandel, NM; Paksoy, N; Paydaş, S; Şakalar, T; Şendur, MAN; Sezer, A; Shbair, A; Tatlı, AM; Yalçın, B; Yücel, Ş; Yumuk, PF; Zeynelgil, E, 2022)	2.44
"Osimertinib is a third-generation EGFR-tyrosine kinase inhibitor approved for the treatment of T790M-positive non-small-cell lung cancer. "	( Acquired EGFR C797G Mutation Detected by Liquid Biopsy as Resistance Mechanism After Treatment With Osimertinib: A Case Report. Baldassarre, G; Baresic, T; Bearz, A; DA Ros, V; DE Carlo, E; Del Conte, A; Doliana, R; Pelizzari, G; Schiappacassi, M; Stanzione, B, )	1.79
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that targets the T790M mutation of EGFR. "	( Efficacy and safety of osimertinib in a Japanese compassionate use program. Ando Makihara, R; Fujiwara, Y; Goto, Y; Horinouchi, H; Kanda, S; Ohe, Y; Sakiyama, N; Yamamoto, N, 2017)	2.21
"Osimertinib is an oral, central nervous system-active, EGFR tyrosine kinase inhibitor (TKI) for the treatment of EGFR T790M-positive advanced NSCLC. "	( EGFR Mutation Analysis for Prospective Patient Selection in Two Phase II Registration Studies of Osimertinib. Cantarini, M; Dearden, S; Hodge, R; Jänne, PA; Jenkins, S; Patel, S; Shepherd, FA; Thress, KS; Weston, S; Yang, JC; Yu, K, 2017)	2.12
"Osimertinib is a new-generation epidermal growth factor inhibitor for the treatment of non-small cell lung cancer. "	( Development and Validation of a Rapid and Sensitive LC-MS/MS Method for the Pharmacokinetic Study of Osimertinib in Rats. Deng, Z; Mu, Y; Sun, P; Xiong, S; Xue, M, 2017)	2.11
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for the treatment of metastatic EGFR T790M mutation-positive non-small cell lung cancer (NSCLC) in patients failing previous TKI therapy. "	( Osimertinib: A third-generation tyrosine kinase inhibitor for treatment of epidermal growth factor receptor-mutated non-small cell lung cancer with the acquired Thr790Met mutation. Agnew, AS; Bollinger, MK; Mascara, GP, 2018)	3.37
"Osimertinib is an effective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved in multiple countries and regions for patients with EGFR T790M mutation-positive non-small cell lung cancer (NSCLC). "	( EGFR G796D mutation mediates resistance to osimertinib. Bai, Y; Hu, M; Liu, L; Lu, X; Ni, J; Wang, J; Wang, Z; Wu, C; Xu, J; Yang, Z; Zheng, D; Zhu, X, 2017)	2.16
"Osimertinib is an EGFR-T790M-specific TKI, which has demonstrated impressive response rates in NSCLC, after failure to first-line anti-EGFR TKIs. "	( Sequential liquid biopsies reveal dynamic alterations of EGFR driver mutations and indicate EGFR amplification as a new mechanism of resistance to osimertinib in NSCLC. Alessi, JV; Bettoni, F; Camargo, AA; Cruz, M; Katz, A; Knebel, FH; Negrão, MV; Reis, LFL; Shimada, AK, 2017)	2.1
"Osimertinib (Tagrisso™) is an oral, CNS-active, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that targets EGFR TKI-sensitizing mutations and, crucially, the T790M mutation that often underlies acquired resistance to EGFR TKI therapy. "	( Osimertinib: A Review in T790M-Positive Advanced Non-Small Cell Lung Cancer. Lamb, YN; Scott, LJ, 2017)	3.34
"Osimertinib is an oral, potent, irreversible EGFR tyrosine kinase inhibitor (TKI) selective for EGFR TKI and T790M resistance mutations. "	( Modulation of Biomarker Expression by Osimertinib: Results of the Paired Tumor Biopsy Cohorts of the AURA Phase I Trial. Angell, HK; Barrett, JC; Blackhall, F; Cantarini, M; Gold, KA; Jacobs, V; Jänne, PA; Schuler, M; Sequist, LV; Su, WC; Thress, KS; Wolf, J; Yang, JC, 2017)	2.17
"Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) recently approved for the treatment of T790M-positive non-small cell lung cancer (NSCLC); however, acquired resistance to osimertinib is evident and resistance mechanisms remain incompletely defined."	( Emergence of EGFR G724S mutation in EGFR-mutant lung adenocarcinoma post progression on osimertinib. Ali, SM; Erlich, RL; Fischer, S; Lovly, CM; Miller, V; Ou, SI; Oztan, A; Raez, LE; Ross, JS; Schrock, AB; Stephens, PJ, 2017)	1.4
"Osimertinib (AZD9291) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that has been approved for the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). "	( Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells. Chen, X; Huang, MY; Jiang, XM; Lu, JJ; Su, MX; Xu, YL; Zhang, LL, 2017)	3.34
"Osimertinib is an oral, third-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that selectively inhibits both EGFR-TKI-sensitizing and EGFR T790M resistance mutations. "	( Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer. Cheng, Y; Chewaskulyong, B; Cho, BC; Cho, EK; Dechaphunkul, A; Gray, JE; Hodge, R; Imamura, F; Kurata, T; Lee, KH; Lee, SM; Marotti, M; Nogami, N; Ohe, Y; Okamoto, I; Planchard, D; Ramalingam, SS; Reungwetwattana, T; Rukazenkov, Y; Soria, JC; Su, WC; Vansteenkiste, J; Voon, PJ; Zhou, C, 2018)	3.37
"Osimertinib 80 mg is a useful therapeutic option for refractory LM after classical EGFR-TKI failure. "	( Standard-dose osimertinib for refractory leptomeningeal metastases in T790M-positive EGFR-mutant non-small cell lung cancer. Fukushima, S; Hata, A; Irie, K; Kaji, R; Katakami, N; Nanjo, S; Okada, H; Okuda, C; Tamura, D, 2018)	2.28
"Osimertinib is an oral, irreversible, central nervous system active epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) selective for both EGFR-TKI sensitizing and T790M resistance mutations. "	( Pharmacokinetics of Osimertinib in Chinese Patients With Advanced NSCLC: A Phase 1 Study. Cantarini, M; Cao, J; Chang, J; Wang, J; Yang, L; Zhang, L; Zhang, Z; Zhao, H, 2018)	2.25
"Osimertinib is a potent, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) selective for EGFR-TKI sensitizing (EGFRm) and T790M resistance mutations. "	( Osimertinib in patients with epidermal growth factor receptor T790M advanced non-small cell lung cancer selected using cytology samples. Cantarini, M; Hodge, R; Kasahara, K; Katakami, N; Kiura, K; Nogami, N; Okamoto, I; Takahashi, T; Uchida, H; Yoh, K, 2018)	3.37
"Osimertinib is a novel, irreversible, mutant-selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor targeting EGFR mutations and the EGFR T790 mutation. "	( Heterogeneity-based, multiple mechanisms in the resistance to osimertinib (AZD9291): A case report. Han, X; Hao, X; Hu, X; Li, J; Li, W; Liu, Y; Shi, Y; Wang, H; Wang, Y; Xing, P; Ying, J, 2018)	2.16
"Osimertinib is a potent, highly selective, irreversible inhibitor of epidermal growth factor receptor (EGFR) and T790M resistance mutation. "	( Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug Label. Ballard, P; Pilla Reddy, V; Sharma, P; Vishwanathan, K; Walker, M, 2018)	2.18
"Osimertinib is a third-generation EGFR TKI approved for the treatment of advanced NSCLC harboring EGFR T790M; however, the activity of osimertinib in EGFR Ex20Ins NSCLC has yet to be fully assessed."	( Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions. Burich, RA; Cheng, M; Cross, DAE; Cuomo, ME; Finlay, MRV; Floc'h, N; Gandara, DR; Keck, JG; Mack, PC; Martin, MJ; McKerrecher, D; Ménard, L; O'Neill, DJ; Orme, JP; Riess, JW; Staniszewska, AD; Vang, DP; Ward, RA, 2018)	1.52
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that can overcome resistance due to the Thr790Met (T790M) mutation. "	( High ratio of T790M to EGFR activating mutations correlate with the osimertinib response in non-small-cell lung cancer. Ariyasu, R; Dotsu, Y; Horiike, A; Inase, N; Kasahara, K; Katayama, R; Kitazono, S; Koyama, J; Nishikawa, S; Nishio, M; Oh-Hara, T; Saiki, M; Sonoda, T; Uchibori, K; Yanagitani, N; Yoshizawa, T, 2018)	2.16
"Osimertinib is a standard second-line therapy for patients who develop EGFR Thr790Met resistance mutation after treatment with first-line epidermal growth factor receptor tyrosine kinase inhibitors. "	( Successful oral desensitization with osimertinib following osimertinib-induced fever and hepatotoxicity: a case report. Fujimoto, D; Hirabatake, M; Hirabayashi, R; Satsuma, Y; Tomii, K, 2018)	2.2
"Osimertinib is an oral, potent, irreversible third-generation EGFR tyrosine kinase inhibitor approved for the treatment of T790M-positive NSCLC patients who failed first- or second-generation EGFR tyrosine kinase inhibitors. "	( Transient Asymptomatic Pulmonary Opacities During Osimertinib Treatment and its Clinical Implication. Ahn, JS; Ahn, MJ; Kim, Y; Lee, H; Lee, HY; Lee, SH; Park, K; Park, SE; Sun, JM, 2018)	2.18
"Osimertinib is a third-generation tyrosine kinase inhibitor, initially approved for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC) with T790M acquired resistance, and now approved in the first-line setting. "	( Osimertinib for Li, G; Nagpal, S; Neal, JW; Soltys, SG; Wakelee, HA; Xie, L, 2019)	3.4
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor recently approved for the first-line treatment of "	( Osimertinib for Li, G; Nagpal, S; Neal, JW; Soltys, SG; Wakelee, HA; Xie, L, 2019)	3.4
"Osimertinib is a safe and effective treatment option for elderly patients with advanced NSCLC who harbor the EGFR mutation."	( Efficacy and Safety Data of Osimertinib in Elderly Patients with NSCLC Who Harbor the Furuta, H; Hida, T; Horio, Y; Kobara, M; Kuroda, H; Sakao, Y; Shimizu, J; Uemura, T; Watanabe, N; Yamaguchi, T; Yatabe, Y; Yoshida, T, 2018)	2.22
"Osimertinib (AZD9291) is a third generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has demonstrated significant clinical benefits in patients with EGFR‑sensitizing mutations or the T790M mutation. "	( Osimertinib (AZD9291) increases radio‑sensitivity in EGFR T790M non‑small cell lung cancer. Li, S; Liu, C; Meng, X; Wang, J; Wang, L; Wang, N; Xing, L; Yang, Z; Yu, J; Zheng, L; Zhu, L, 2019)	3.4
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), specifically designed to inhibit EGFR sensitizing and T790M acquired mutations, minimizing exposure in EGFR-wild-type tissues. "	( Safety of osimertinib in EGFR-mutated non-small cell lung cancer. Mezquita, L; Planchard, D; Varga, A, 2018)	2.33
"Osimertinib (AZD9291) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that has been approved for the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). "	( Identification of osimertinib (AZD9291) as a lysine specific demethylase 1 inhibitor. Fu, DJ; Guo, YJ; Hu, B; Li, ZR; Liu, HM; Suo, FZ; Yu, B; Zheng, YC, 2019)	2.29
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is selective for both EGFR-TKI-sensitizing and T790M (threonine-to-methionine substitution at codon 790)-resistance mutations. "	( Osimertinib in patients with T790M mutation-positive, advanced non-small cell lung cancer: Long-term follow-up from a pooled analysis of 2 phase 2 studies. Ahn, MJ; Bazhenova, L; Cantarini, M; Goss, G; Hida, T; Jänne, PA; Mann, H; Mitsudomi, T; Ramalingam, SS; Sequist, LV; Shepherd, FA; Tsai, CM; Yang, JCH, 2019)	3.4
"Osimertinib is a third-generation oral small molecule inhibitor of EGFR, active against the common targetable activating EGFR mutations in L858R and exon 19 deletion; it also inhibits the T790M mutation."	( Role of osimertinib in the treatment of EGFR-mutation positive non-small-cell lung cancer. Carlisle, JW; Ramalingam, SS, 2019)	1.67
"Osimertinib is a third-generation EGFR-tyrosine kinase inhibitor (TKI). "	( Osimertinib Plus Durvalumab versus Osimertinib Monotherapy in EGFR T790M-Positive NSCLC following Previous EGFR TKI Therapy: CAURAL Brief Report. Chang, GC; Collins, B; Horn, L; Kim, DW; Laus, G; Lee, GW; Lee, JS; Lee, SS; Lee, YG; Pisetzky, F; Shepherd, FA; Wei, YF; Yang, JC, 2019)	3.4
"Osimertinib is a potent, third-generation, irreversible, central nervous system active epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that selectively inhibits EGFR-TKI sensitizing and EGFR T790M resistance mutations. "	( Modulation of Fexofenadine Pharmacokinetics by Osimertinib in Patients With Advanced EGFR-Mutated Non-Small Cell Lung Cancer. Calvo, E; deCastro Carpeno, J; Kim, SW; Laus, G; Lee, JS; Mann, H; Moreno, V; Vishwanathan, K; Weilert, D, 2019)	2.21
"Osimertinib is an EGFR tyrosine kinase inhibitor (TKI) with antitumor activity in non-small cell lung cancer (NSCLC) with EGFR T790 M mutations. "	( Patterns of progression on osimertinib in EGFR T790M positive NSCLC: A Swiss cohort study. Aeppli, S; Britschgi, C; Demmer, I; Foerbs, D; Früh, M; Gautschi, O; Janthur, W; Jochum, W; Klingbiel, D; Pless, M; Rothschild, S; Schmid, S; Wannesson, L, 2019)	2.25
"Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effective against EGFR T790M mutation-positive non-small-cell lung cancer (NSCLC) in patients who have good performance status (PS). "	( Osimertinib for patients with EGFR T790M mutation-positive non-small-cell lung cancer and a poor performance status. Akamatsu, H; Daga, H; Hisamatsu, Y; Imai, H; Kimura, M; Ko, R; Miyashita, Y; Nakashima, K; Nishino, K; Sugimoto, T; Taira, T; Takahashi, T, 2019)	3.4
"Osimertinib is a third generation EGFR-tyrosine kinase inhibitor (TKI) with preclinical and early clinical studies showing activity against LMC resistant to previous TKI treatments and acquired T790M mutation."	( Osimertinib in the treatment of leptomeningeal disease in T790M-negative, epidermal growth factor receptor-mutated non-small cell lung cancer: a case report. Chen, J; Soudy, H, 2019)	2.68
"Osimertinib is a tyrosine kinase inhibitor (TKI) of the mutated epidermal growth factor receptor (EGFRm) with observed efficacy in patients with brain metastases. "	( A PET study in healthy subjects of brain exposure of Brown, AP; Cselényi, Z; Farde, L; Halldin, C; Johnström, P; Jucaite, A; Moein, MM; Schou, M; Varnäs, K; Varrone, A; Vazquez-Romero, A; Vishwanathan, K, 2020)	2
"Osimertinib is a standard treatment for epidermal growth factor receptor (EGFR)-mutated, T790M-positive patients with progression during EGFR-tyrosine kinase inhibitor (TKI) therapy. "	( Phase I/II Study of Osimertinib With Bevacizumab in EGFR-mutated, T790M-positive Patients With Progressed EGFR-TKIs: West Japan Oncology Group 8715L (WJOG8715L). Akamatsu, H; Daga, H; Katakami, N; Morita, S; Nakagawa, K; Tachihara, M; Teraoka, S; Yamamoto, N, 2019)	2.28
"Osimertinib is a tyrosine kinase inhibitor (TKI) that is an essential agent for the treatment of epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC). "	( Re-administration of osimertinib in osimertinib-acquired resistant non-small-cell lung cancer. Hotta, K; Ichihara, E; Kiura, K; Kubo, T; Maeda, Y; Ninomiya, K; Ohashi, K; Rai, K; Tabata, M; Tanaka, H, 2019)	2.28
"Osimertinib is a drug used to target lung cancer but its toxicity is not fully understood."	( Osimertinib-induced severe interstitial lung disease: A case report. Fan, M; Mo, T; Shen, L; Yang, L, 2019)	2.68
"Osimertinib is an effective third-generation tyrosine kinase inhibitor (TKI) for EGFR-mutant lung cancers. "	( A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib. Aisner, J; Burley, SK; Castellano, GM; Ganesan, S; Pine, SR; Vallat, B; Yu, HA, 2019)	2.19
"Osimertinib is a third-generation, irreversible, oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that potently and selectively inhibits both EGFR sensitizing mutation and EGFR T790M and has demonstrated efficacy in non-small cell lung cancer (NSCLC) central nervous system (CNS) metastases. "	( Osimertinib in Patients with T790M-Positive Advanced Non-small Cell Lung Cancer: Korean Subgroup Analysis from Phase II Studies. Ahn, MJ; Cho, BC; Han, JY; Kang, JH; Kim, DW; Kim, SW; Lee, JS; Mitsudomi, T; Yang, JC, 2020)	3.44
"Osimertinib (AZD9291) is a novel mono-anilino-pyrimidine third-generation EGFR TKI targeting both sensitizing and T790M EGFR-mutation which showed promising results in T790M-positive NSCLC."	( Osimertinib (AZD9291) and CNS Response in Two Radiotherapy-Naïve Patients with EGFR-Mutant and T790M-Positive Advanced Non-Small Cell Lung Cancer. Chiari, R; Chiarini, P; Crinò, L; Ludovini, V; Maiettini, D; Metro, G; Ricciuti, B, 2016)	2.6
"Osimertinib (AZD9291) is a potent, selective, irreversible inhibitor of EGFR-sensitizing (exon 19 and L858R) and T790M-resistant mutation. "	( Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic-Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104. Ashton, S; Ballard, P; Cross, D; Mellor, MJ; Powell, SJ; Yates, JW, 2016)	2.09
"Osimertinib is an EGFR inhibitor licensed for the treatment of EGFR-mutant, T790M-positive NSCLC. "	( Transient Asymptomatic Pulmonary Opacities Occurring during Osimertinib Treatment. Camidge, DR; Noonan, SA; Sachs, PB, 2016)	2.12
"Osimertinib (AZD9291) is an oral, potent, irreversible EGFR tyrosine-kinase inhibitor selective for EGFR tyrosine-kinase inhibitor sensitising mutations, and the EGFR Thr790Met resistance mutation. "	( Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study. Bazhenova, L; Cantarini, M; Chang, GC; Chu, Q; Crino, L; Dunphy, F; Ghiorghiu, S; Goss, G; Han, JY; Hida, T; Juan, O; Kang, JH; Lee, JS; Majem, M; Mann, H; Mitsudomi, T; Nishio, M; Satouchi, M; Shepherd, FA; Tsai, CM, 2016)	3.32
"Osimertinib is an oral, highly selective, irreversible inhibitor of both EGFR-activating mutations and the T790M-resistance mutation, while sparing the activity of wild-type EGFR This article reviews clinical trial development of osimertinib in patients with NSCLC, presenting efficacy and safety evidence for its value in the EGFR T790M mutation-positive population and in different settings, including patients with metastatic disease."	( Osimertinib in the treatment of patients with epidermal growth factor receptor T790M mutation-positive metastatic non-small cell lung cancer: clinical trial evidence and experience. Planchard, D; Sullivan, I, 2016)	2.6
"Osimertinib (AZD9291) is a novel EGFR tyrosine kinase inhibitor (TKI) that is potent and selective for sensitising (EGFRm) and T790M resistance mutations."	( Inhibition of oxidative phosphorylation suppresses the development of osimertinib resistance in a preclinical model of EGFR-driven lung adenocarcinoma. Ashton, S; Cross, D; Eberlein, C; Martin, MJ; Robinson, D; Taylor, M, 2016)	1.39
"Osimertinib is a third-generation EGFR TKI that was designed to overcome resistance from T790M mutations."	( Osimertinib, a third-generation tyrosine kinase inhibitor targeting non-small cell lung cancer with EGFR T790M mutations. Jimeno, A; McCoach, CE, 2016)	2.6
"Osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that is selective for both EGFR-TKI sensitizing and T790M resistance mutations in patients with non-small-cell lung cancer. "	( Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer. Ahn, M-J; Akamatsu, H; Garassino, MC; Ghiorghiu, S; He, Y; Kim, HR; Lee, CK; Mann, H; Marotti, M; Mok, TS; Papadimitrakopoulou, VA; Ramalingam, SS; Sebastian, M; Shepherd, FA; Templeton, A; Theelen, WS; Wu, Y-L, 2017)	3.34
"Osimertinib is a third-generation oral, potent, and irreversible EGFR-TKI."	( Rapid intracranial response to osimertinib, without radiotherapy, in nonsmall cell lung cancer patients harboring the EGFR T790M mutation: Two Case Reports. Hamaguchi, M; Hirata, H; Kida, H; Kijima, T; Koba, T; Kumanogoh, A; Kuroyama, M; Nagatomo, I; Naito, Y; Otsuka, T; Takeda, Y; Takimoto, T, 2017)	1.46

Excerpt	Reference	Relevance
"Osimertinib has an impressive antitumor activity compared with prior EGFR-TKI and chemotherapy with an acceptable response and tolerable AEs. "	( The efficacy and safety of osimertinib in treating nonsmall cell lung cancer: A PRISMA-compliant systematic review and meta-analysis. Guo, X; He, J; Li, X; Liu, J; Shao, Y, 2020)	2.3
"Osimertinib has a favorable safety profile compared to platinum-doublet chemotherapy."	( Osimertinib: A third-generation tyrosine kinase inhibitor for treatment of epidermal growth factor receptor-mutated non-small cell lung cancer with the acquired Thr790Met mutation. Agnew, AS; Bollinger, MK; Mascara, GP, 2018)	2.64
"Osimertinib (AZD9291) has an efficacy superior to that of standard EGFR-tyrosine kinase inhibitors for the first-line treatment of patients with "	( Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in Kurihara, E; Namba, K; Ogoshi, Y; Sato, H; Shien, K; Soh, J; Takahashi, Y; Takeda, T; Tomida, S; Torigoe, H; Toyooka, S; Yamamoto, H; Yoshioka, T, 2019)	2.19
"Osimertinib has been identified as a promising therapeutic drug targeting for EGFR T790M mutant non-small cell lung cancer (NSCLC). "	( Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors. Gao, H; Rao, Y; Yang, X; Yang, Z, 2017)	2.19
"Osimertinib has been approved as a first-line treatment for non-small-cell lung cancer (NSCLC) patients whose tumor carries EGFR activation and / or resistant mutations. "	( Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC. Chen, G; Gao, M; Wu, J; Zhou, P, 2018)	2.19
"Osimertinib has shown favorable efficacy on second-line and first-line treatments in EGFR-mutant advanced nonsmall cell lung cancer (NSCLC). "	( Resistance mechanisms to osimertinib and emerging therapeutic strategies in nonsmall cell lung cancer. Tian, W; Wu, F; Yu, D; Zeng, Y, 2022)	2.47
"Osimertinib has been recommended as first-line treatment of advanced NSCLC with EGFR mutations."	( Colonic mucosal diffuse congestion associated with Osimertinib. Cheng, YX; Lei, MH; Luo, Y; Ren, XJ, 2023)	1.88
"Osimertinib has been the first-line treatment for EGFR-mutated NSCLC."	( Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance. Cai, Z; Dong, H; Hou, Y; Li, J; Min, W; Shen, H; Wang, L; Wang, X; Wu, Y; Xiao, Y; Yang, P; Ye, X; Zhu, Y, 2023)	1.63
"Osimertinib has been approved by the Food and Drug Administration (FDA) of the United States (US) for the treatment of progressive non-small cell lung cancer (NSCLC) that has acquired T790M mutation during treatment with first-line epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI). "	( When compared to plasma-based detection, osimertinib-treated non-small cell lung cancer (NSCLC) with tissue rebiopsy-confirmed acquired T790M mutation is associated with better survival. Ho, JCM; Ip, MSM; Kwok, WC; Lam, DCL; Lui, MMS; Tam, TCC, 2021)	2.33
"Osimertinib has shown promising activity in patients with leptomeningeal metastases (LMs) of EGFR-positive NSCLC at 160 mg once daily (qd) (BLOOM; NCT02228369). "	( Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis. Ahn, MJ; Brown, AP; Cheng, Y; Chiu, CH; Crawford, J; Goldberg, SB; Greystoke, A; Han, JY; Huang, X; Johnson, M; Mendoza-Naranjo, A; Mok, T; Vishwanathan, K; Yates, JWT; Zhao, Y, 2020)	3.44
"Osimertinib has shown good efficacy in SqCC harboring a "primary" resistance mechanism (EGFR T790M)."	( Osimertinib for compound EGFR exon 19 deletion/T790M mutated lung squamous cell carcinoma. Liu, W; Peng, M; Wen, Q; Wu, X; Yu, F, 2020)	2.72
"Osimertinib (AZD9291) has been widely used for the treatment of EGFR mutant non-small cell lung cancer. "	( TGFβ2-mediated epithelial-mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance. Chen, XP; Huang, MY; Jiang, XM; Lu, JJ; Su, MX; Xu, YL; Ye, RD; Ye, ZH; Yuan, LW; Zhang, LL; Zhu, H, 2021)	2.28
"Osimertinib has been reported to be effective against central nervous system (CNS) metastasis from activating EGFR mutation-positive NSCLC. "	( A Phase II Study of Osimertinib for Radiotherapy-Naive Central Nervous System Metastasis From NSCLC: Results for the T790M Cohort of the OCEAN Study (LOGIK1603/WJOG9116L). Chibana, K; Ebi, N; Fukuda, M; Harada, T; Inoue, K; Ito, K; Kenmotsu, H; Kirita, K; Miura, S; Mukae, H; Nakagawa, K; Nakatani, Y; Suetsugu, T; Sugio, K; Tanaka, K; Wakuda, K; Yamaguchi, H; Yamamoto, N; Yokoyama, T; Yoshimura, K, 2021)	2.39
"Osimertinib has been approved in numerous countries for use in patients with T790M-positive advanced NSCLC."	( Osimertinib: A Review in T790M-Positive Advanced Non-Small Cell Lung Cancer. Lamb, YN; Scott, LJ, 2017)	2.62
"Osimertinib has shown systemic efficacy in patients with CNS metastases, and early clinical evidence shows efficacy in the CNS."	( CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ahn, MJ; Bazhenova, L; Cantarini, M; Crinò, L; de Marinis, F; Felip, E; Goss, G; Hodge, R; Jänne, PA; Johnson, M; Mitsudomi, T; Morabito, A; Shepherd, FA; Tsai, CM; Yang, JC, 2018)	1.55
"Osimertinib has been approved in these patients, but data in octogenarians remain rare."	( Real-Life Efficacy of Osimertinib in Pretreated Octogenarian Patients with T790M-Mutated Advanced Non-small Cell Lung Cancer. Andre, M; Auliac, JB; Chiappa, AM; Chouaid, C; Corre, R; Fournel, P; Hauss, PA; Lamy, R; Madelaine, J; Masson, P; Quere, G; Raymond, S; Saboundji, K; Vergnenegre, A, 2019)	1.55
"Osimertinib has been designed to target the EGFR T790M mutation that is often present in NSCLC patients with acquired EGFR TKI resistance, while sparing wild-type EGFR."	( Osimertinib: First Global Approval. Greig, SL, 2016)	2.6
"Osimertinib has been demonstrated to overcome the epidermal growth factor receptor (EGFR)-T790M, the most relevant acquired resistance to first-generation EGFR-tyrosine kinase inhibitors (EGFR-TKIs). "	( Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Araki, M; Fujita, N; Inase, N; Kamada, M; Katayama, R; Okuno, Y; Sato, S; Uchibori, K, 2017)	2.15

Excerpt	Reference	Relevance
"Osimertinib efficacy was lower than that of other EGFR–tyrosine kinase inhibitors."	( First-line osimertinib in EGFR mutation-positive non-small cell lung cancer patients with poor performance status. Hakozaki, T; Kato, Y; Kitagawa, S; Okuma, Y; Takamizawa, S; Zenke, Y, 2022)	1.83

Excerpt	Reference	Relevance
"Osimertinib treatment will increase national cancer spending by $220 million in the first year and increase to $474 million in the fifth year."	( Evaluation of osimertinib for advanced non-small cell lung cancer with leptomeningeal metastases: a cost-effectiveness and budget impact analysis. Guo, X; Huang, L; Huang, X; Lin, S; Luo, S; Weng, X; Xu, X; Zhou, W, 2022)	1.8
"Osimertinib treatment following first/second generation EGFR-TKI treatment or chemotherapy resulted in improved survival benefit."	( Comparing survival and treatment response of patients with acquired T790M mutation second-line osimertinib versus sequential treatment of chemotherapy followed by osimertinib: A real-world study. Chang, HC; Chang, YP; Huang, KT; Lai, CH; Lin, MC; Tseng, CC; Wang, CC, 2021)	1.56
"Osimertinib treatment also reduced the risk of tumors spreading to the brain and spinal cord, otherwise known as the central nervous system (also called CNS)."	( A plain language summary of results from the ADAURA study: osimertinib after surgery for patients who have early-stage EGFR-mutated non-small cell lung cancer. Akewanlop, C; Atasoy, A; Bonanno, L; de Marinis, F; Domine, M; Goldman, JW; Grohe, C; Herbst, RS; Hodge, R; John, T; Kato, T; Kim, SW; Laktionov, K; Lee, KY; Lu, S; Majem, M; Rukazenkov, Y; Shepherd, FA; Tsuboi, M; Vu, HV; Wu, YL; Yu, CJ; Zeng, L, 2021)	1.59
"Osimertinib+pemetrexed treatment delayed the emergence of resistance relative to monotherapy in vitro and in vivo. "	( A Novel Molecular Target in Gemma, A; Hisakane, K; Matsuda, K; Nakamichi, S; Noro, R; Seike, M; Sugano, T; Takano, N; Yoshikawa, A, 2022)	2.16
"For osimertinib treatment in first-line settings, the frequency of DRP was considerably elevated to 18 %, and half of these patients exhibited TAPO features."	( Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting. Arai, D; Fujimoto, D; Hara, S; Hashimoto, K; Hino, A; Ikeda, H; Inaba, M; Kobe, H; Maruyama, H; Matsumoto, H; Morimoto, T; Oya, Y; Sakata, S; Sakata, Y; Sato, Y; Shibaki, R; Sumikawa, H; Suzuki, H; Tamiya, M; Tsukita, Y; Tsumura, S; Yokoi, T, 2022)	1.55
"Osimertinib treatment was associated with a PFS of 11.17 months [7.80, 14.55] which was longer in treatment-naïve (20.30 [15.37, 25.23]) than in prior EGFR-TKI-treated (10.20 [9.60, 10.80]) patients."	( Efficacy of osimertinib for the treatment of previously EGFR TKI treated NSCLC patients: a meta-analysis. Dong, MS; Li, ZX; Sun, Q; Tang, MS; Xia, QJ; Zhao, W, 2020)	1.66
"Osimertinib treatment yields approximately 10 months PFS in prior EGFR-TKI-treated and 20 months in treatment-naïve NSCLC patients. "	( Efficacy of osimertinib for the treatment of previously EGFR TKI treated NSCLC patients: a meta-analysis. Dong, MS; Li, ZX; Sun, Q; Tang, MS; Xia, QJ; Zhao, W, 2020)	2.38
"Osimertinib can be a treatment option for patients with lung ASC harboring germline EGFR T790M mutation."	( Significant Benefits of Osimertinib Against Adenosquamous Carcinoma Harboring Germline T790M Mutation. Huo, R; Jiao, J; Li, J; Li, X; Shang, Y; Shi, J; Wang, K, 2020)	2.31
"Osimertinib is a new treatment option that demonstrated a superior efficacy over standard epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) or platinum-based chemotherapy."	( A review of Osimertinib in NSCLC and pharmacist role in NSCLC patient care. Al-Quteimat, OM; Amer, AM, 2020)	1.66
"Osimertinib is the treatment of choice for advanced EGFR-mutant non-small cell lung cancer (NSCLC). "	( Concurrent use of aspirin with osimertinib is associated with improved survival in advanced EGFR-mutant non-small cell lung cancer. Fang, B; He, Y; Heymach, JV; Hong, L; Hubert, SM; Jack Lee, J; Le, X; Lewis, J; Liu, X; Nilsson, M; Rinsurongkawong, W; Roth, J; Spelman, A; Swisher, S; Wu, S; Zhang, J, 2020)	2.29
"Osimertinib-treated patients tended to have a lower risk of CNS metastases compared with those treated with first-generation EGFR-TKIs (p = 0.059)."	( Survival outcomes and symptomatic central nervous system (CNS) metastasis in EGFR-mutant advanced non-small cell lung cancer without baseline CNS metastasis: Osimertinib vs. first-generation EGFR tyrosine kinase inhibitors. Chu, L; Chu, X; Guo, T; Li, S; Li, Y; Liang, F; Liu, Q; Ni, J; Qu, J; Wang, B; Wang, S; Yang, X; Ye, L; Yu, F; Zeng, Y; Zhao, Y; Zhou, Y; Zhu, Z; Zou, L, 2020)	1.48
"Osimertinib treatment improved her condition immediately."	( Late recurrence of lung adenocarcinoma harboring EGFR exon 20 insertion (A763_Y764insFQEA) mutation successfully treated with osimertinib. Goto, K; Honma, K; Imamura, F; Inoue, T; Kawachi, H; Kawamura, T; Kukita, Y; Kumagai, T; Kunimasa, K; Matsumoto, S; Nishino, K; Sugimoto, N; Tamiya, M; Yamasaki, T, 2021)	1.55
"In osimertinib-treated NSCLC patients with BMs, oligo-BM status could be used as a potential factor to select patients for upfront cranial RT. "	( Clinical Value of Upfront Cranial Radiation Therapy in Osimertinib-Treated Epidermal Growth Factor Receptor-Mutant Non-Small Cell Lung Cancer With Brain Metastases. Chu, L; Chu, X; Guo, T; Li, S; Li, Y; Liu, Q; Ni, J; Wang, S; Yang, X; Ye, L; Yu, F; Yu, W; Zeng, W; Zeng, Y; Zhao, Y; Zhou, Y; Zhu, Z; Zou, L, 2021)	1.49
"Osimertinib is the main treatment choice for pretreated patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) T790M mutations. "	( Survival benefit of osimertinib combination therapy in patients with T790M-positive non-small-cell lung cancer refractory to osimertinib treatment. Chang, CC; Lin, CC; Lin, CY; Lin, MC; Su, PL; Su, WC; Tsai, JS; Tseng, YL; Wang, CC; Wu, YL; Yang, SC; Yen, YT, 2021)	2.39
"Osimertinib treatment was discontinued, given the possibility that it had reactivated the patient's immune-related colitis."	( Osimertinib reactivated immune-related colitis after treatment with anti-PD1 antibody for non-small cell lung cancer. Harada, N; Miura, N; Takenaka, T; Takeo, S; Yamazaki, K, 2017)	2.62
"Osimertinib treatment for T790M mutation NSCLC is unlikely to be cost-effective from the perspectives of the United States and the People's Republic of China. "	( Cost-Effectiveness of Osimertinib for EGFR Mutation-Positive Non-Small Cell Lung Cancer after Progression following First-Line EGFR TKI Therapy. Gu, X; Wu, B; Zhang, Q, 2018)	2.24
"Osimertinib offers a new treatment option that overcomes this problem."	( [Patient with Three EGFR Mutations - Gradual Development of Resistance to Previous Targeted Treatment]. Baxa, J; Benešová, L; Minárik, M; Mukenšnabl, P; Pešek, M; Svatoň, M, )	0.85
"Osimertinib is standard treatment for patients with advanced EGFR T790M-mutated non-small-cell lung cancer who have been pre-treated with EGFR-tyrosine kinase inhibitors (TKIs). "	( Cell-Free Plasma DNA-Guided Treatment With Osimertinib in Patients With Advanced EGFR-Mutated NSCLC. Absenger, G; Baumgartner, B; Buder, A; Bundalo, T; Burghuber, OC; Errhalt, P; Filipits, M; Hochmair, MJ; Mikes, RE; Patocka, K; Pirker, R; Prosch, H; Schenk, P; Schwab, S; Setinek, U, 2018)	2.19
"Osimertinib treatment was independently associated with longer overall, post-progression, and brain metastasis-free survival."	( Clinical characteristics of T790M-positive lung adenocarcinoma after resistance to epidermal growth factor receptor-tyrosine kinase inhibitors with an emphasis on brain metastasis and survival. Hong, MH; Joo, JW; Shim, HS, 2018)	1.2
"Osimertinib is the best treatment choice for patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) whose disease progresses on a first- or second-generation EGFR-tyrosine kinase inhibitor due to acquired T790M mutation. "	( Successful Response to Osimertinib Rechallenge after Intervening Chemotherapy in an EGFR T790M-Positive Lung Cancer Patient. Baglivo, S; Bellezza, G; Chiari, R; Ludovini, V; Metro, G; Rebonato, A; Siggillino, A, 2018)	2.23
"Osimertinib as first-line treatment could gain more health benefits in comparison with standard EGFR-TKIs or second-line use of osimertinib. "	( Cost-Effectiveness of Osimertinib in Treating Newly Diagnosed, Advanced EGFR-Mutation-Positive Non-Small Cell Lung Cancer. Gu, X; Wu, B; Xie, F; Zhang, Q, 2019)	2.27
"Osimertinib as first-line treatment yielded the greatest health outcomes but is not a cost-effective strategy for lung cancer in the U.S. "	( Cost-Effectiveness of Osimertinib in Treating Newly Diagnosed, Advanced EGFR-Mutation-Positive Non-Small Cell Lung Cancer. Gu, X; Wu, B; Xie, F; Zhang, Q, 2019)	2.27
"Osimertinib is a standard treatment for epidermal growth factor receptor (EGFR)-mutated, T790M-positive patients with progression during EGFR-tyrosine kinase inhibitor (TKI) therapy. "	( Phase I/II Study of Osimertinib With Bevacizumab in EGFR-mutated, T790M-positive Patients With Progressed EGFR-TKIs: West Japan Oncology Group 8715L (WJOG8715L). Akamatsu, H; Daga, H; Katakami, N; Morita, S; Nakagawa, K; Tachihara, M; Teraoka, S; Yamamoto, N, 2019)	2.28
"This treatment with osimertinib led to serious cardiac failure but no significant reduction in NSCLC tumor size."	( Aumolertinib Effectively Reduces Clinical Symptoms of an EGFR L858R-Mutant Non-Small Cell Lung Cancer Case Coupled With Osimertinib-Induced Cardiotoxicity: Case Report and Review. Liu, H; Yang, J; Zhang, Q, 2022)	1.24
"Treatment with osimertinib was first suspended and then resumed after stabilization of the HF. "	( Possible heart failure caused by osimertinib in a lung cancer patient. Alvarez, R; Collado-Borrell, R; Escudero-Vilaplana, V; Herranz, A; Narrillos-Moraza, Á; Ruiz-Briones, P; Sanjurjo, M; Vicente-Valor, J; Villanueva-Bueno, C, 2023)	1.54
"Treatment with osimertinib was initiated."	( Bevacizumab Combined with Icotinib Overcomes Osimertinib Resistance in a Patient of Non-Small Cell Lung Cancer. Ji, YX; Mu, XY; Sun, L; Zhang, L, 2019)	1.11
"Treatment with osimertinib improved his symptoms, resulting in discharge to home."	( [A Case of Multiple Brain Tumors Successfully Diagnosed with Liquid Biopsy and Treated with Osimertinib]. Fujioka, M; Katsurada, N; Kobayashi, K; Koyama, K; Mimura, C; Nameta, M; Nishimura, Y; Tachihara, M; Terashita, T; Umezawa, K; Yamamoto, M; Yumura, M, 2021)	1.18
"Treatment with osimertinib was started."	( Osimertinib Administration as the Primary Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy for Brain Metastasis of De Novo T790M-positive Lung Cancer. Fukao, A; Horikawa, S; Ikeue, T; Kawachi, H; Noguchi, S; Sugita, T; Tajiri, T; Terashita, S, 2019)	2.3

Excerpt	Reference	Relevance
"These data enhance our understanding of patients' experiences of symptoms/side effects, which could increase the accuracy of the osimertinib benefit-risk assessment, guide management of adverse events, and improve the information given to patients receiving the drug."	( Patient Experience of Symptoms and Side Effects when Treated with Osimertinib for Advanced Non-Small-Cell Lung Cancer: A Qualitative Interview Substudy. Blackhall, F; Braam, L; Kim, HR; Martin, ML; Pillai, RN; Rydén, A; Walding, A, 2017)	0.9
" Although the toxicity of osimertinib was mild in most patients, three patients had severe adverse events: two developed interstitial lung disease (ILD) and one developed Grade 3 hepatotoxicity."	( Efficacy and safety of osimertinib in a Japanese compassionate use program. Ando Makihara, R; Fujiwara, Y; Goto, Y; Horinouchi, H; Kanda, S; Ohe, Y; Sakiyama, N; Yamamoto, N, 2017)	1.07
"Dermatologic adverse events (dAEs) are common with the use of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy."	( Osimertinib: A Novel Dermatologic Adverse Event Profile in Patients with Lung Cancer. Choi, J; Chu, CY; Eaby-Sandy, B; Lacouture, ME; Langer, CJ, 2018)	1.92
"Appropriate prevention and management of dermatologic adverse events (dAEs) associated with the use of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) may help patients to continue therapy and lessen any negative impact on their quality of life."	( Osimertinib: A Novel Dermatologic Adverse Event Profile in Patients with Lung Cancer. Choi, J; Chu, CY; Eaby-Sandy, B; Lacouture, ME; Langer, CJ, 2018)	1.92
" Efficacy and safety indicators, such as EGFR-tyrosine kinase inhibitor (TKI)-related adverse events (AEs) and osimertinib-associated hematotoxicity, were evaluated in elderly patients (elderly group, EG; age, ≥75 years) by comparing them with younger patients (non-EG; aged <75 years)."	( Efficacy and Safety Data of Osimertinib in Elderly Patients with NSCLC Who Harbor the Furuta, H; Hida, T; Horio, Y; Kobara, M; Kuroda, H; Sakao, Y; Shimizu, J; Uemura, T; Watanabe, N; Yamaguchi, T; Yatabe, Y; Yoshida, T, 2018)	0.99
"Osimertinib is a safe and effective treatment option for elderly patients with advanced NSCLC who harbor the EGFR mutation."	( Efficacy and Safety Data of Osimertinib in Elderly Patients with NSCLC Who Harbor the Furuta, H; Hida, T; Horio, Y; Kobara, M; Kuroda, H; Sakao, Y; Shimizu, J; Uemura, T; Watanabe, N; Yamaguchi, T; Yatabe, Y; Yoshida, T, 2018)	2.22
" However, the therapeutic strategy in the EGFR-mutated population is changing, following the FLAURA study in untreated EGFR-mutated patients, in which osimertinib improved progression-free survival compared to other TKIs, with a similar toxicity profile but a lower serious adverse event rate."	( Safety of osimertinib in EGFR-mutated non-small cell lung cancer. Mezquita, L; Planchard, D; Varga, A, 2018)	1.08
" The primary endpoints were overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and adverse events (AEs)."	( Efficacy and safety of osimertinib in treating EGFR-mutated advanced NSCLC: A meta-analysis. Fan, J; Luo, P; Qian, R; Yi, L; Zhang, J, 2019)	0.82
" Adverse events were minimal except for one case of pneumonitis."	( Efficacy, safety, and resistance profile of osimertinib in T790M mutation-positive non-small cell lung cancer in real-world practice. Choi, CM; Ji, WJ; Kim, WS; Lee, JC; Oh, DK; Rho, JK; Yoon, SK, 2019)	0.78
"Concurrent programmed death-ligand-1 (PD-(L)1) plus osimertinib is associated with severe immune related adverse events (irAE) in epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC)."	( Severe immune-related adverse events are common with sequential PD-(L)1 blockade and osimertinib. Arbour, KC; Gadgeel, SM; Girshman, J; Hellmann, MD; Iqbal, AN; Kris, MG; Riely, GJ; Rizvi, H; Schoenfeld, AJ; Yu, HA, 2019)	0.99
" These results reveal that autophagy plays an adverse role in osimertinib cytotoxicity through inducing stem cell-like properties."	( Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer. Feng, M; He, Y; Hu, C; Jiao, L; Li, L; Lin, C; Lu, C; Wang, Y; Wu, H; Ye, J; Zhang, D; Zhang, K, 2019)	1.04
" Response rate (RR) and other endpoints (progression-free survival [PFS], overall survival [OS], disease control rate [DCR], stable disease rate, and adverse events) were assessed."	( Effectiveness and safety of osimertinib in patients with metastatic EGFR T790M-positive NSCLC: An observational real-world study. Cao, Y; Hu, H; Lin, T; Qiu, X; Xiao, G, 2019)	0.81
" However, recent studies have suggested that osimertinib could increase the frequency of serious adverse events (AEs) if administered immediately after immune checkpoint inhibitor (ICI) treatment."	( Severe hepatotoxicity due to osimertinib after nivolumab therapy in patients with non-small cell lung cancer harboring EGFR mutation. Hashimoto, K; Kagamu, H; Kaira, K; Kawasaki, T; Kobayashi, K; Miura, Y; Mochida, S; Mouri, A; Murayama, Y; Nishihara, F; Shinomiya, S; Shiono, A; Yamaguchi, O, 2020)	1.11
" The clinical characteristics, efficacy, and adverse events were retrospectively investigated."	( Osimertinib, a third-generation EGFR tyrosine kinase inhibitor: A retrospective multicenter study of its real-world efficacy and safety in advanced/recurrent non-small cell lung carcinoma. Arai, R; Kasai, T; Kishikawa, T; Nakachi, I; Okada, M; Sata, M; Soda, S; Takigami, A, 2020)	2
" Adverse events of grade ≥ 3 were reported in 15 patients (26."	( Osimertinib, a third-generation EGFR tyrosine kinase inhibitor: A retrospective multicenter study of its real-world efficacy and safety in advanced/recurrent non-small cell lung carcinoma. Arai, R; Kasai, T; Kishikawa, T; Nakachi, I; Okada, M; Sata, M; Soda, S; Takigami, A, 2020)	2
" However, the incidence of ≥ grade 3 adverse events, especially pneumonitis, was higher than that previously reported by other studies."	( Osimertinib, a third-generation EGFR tyrosine kinase inhibitor: A retrospective multicenter study of its real-world efficacy and safety in advanced/recurrent non-small cell lung carcinoma. Arai, R; Kasai, T; Kishikawa, T; Nakachi, I; Okada, M; Sata, M; Soda, S; Takigami, A, 2020)	2
" We conducted a disproportionality analysis of the adverse events (AEs) of EGFR-TKIs (gefitinib, erlotinib, afatinib, osimertinib) by data mining using the FDA adverse event reporting system (AERS) database, and by calculating the reporting odds ratios (ROR) with 95% confidence intervals."	( Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System. Chen, H; Huang, J; Luo, Z; Meng, L; Sun, S; Yang, B, 2020)	0.77
" Conclusions According to our study findings, afatinib treatment after osimertinib-induced ILD is considered safe and effective and it can be used as one of the treatment options for NSCLC following osimertinib-induced ILD."	( Safety and efficacy of afatinib for the treatment of non-small-cell lung cancer following osimertinib-induced interstitial lung disease: A retrospective study. Hirashima, T; Kanai, T; Morishita, N; Nasu, S; Noda, Y; Okamoto, N; Samejima, Y; Shiroyama, T; Suzuki, H; Tanaka, A, 2020)	1.01
" All the studies that mentioned the overall survival (OS), progression-free survival (PFS), treatment response, and adverse events (AEs) of osimertinib were involved in our study."	( The efficacy and safety of osimertinib in treating nonsmall cell lung cancer: A PRISMA-compliant systematic review and meta-analysis. Guo, X; He, J; Li, X; Liu, J; Shao, Y, 2020)	1.06
" Common grade 3 or higher treatment-related adverse events (TRAE) were hypertension (8%) and platelet count decreased (16%); grade 5 TRAE (subdural hemorrhage) occurred in 1 patient."	( Phase I Study of the Efficacy and Safety of Ramucirumab in Combination with Osimertinib in Advanced T790M-positive Chao, BH; Gao, L; Garrido, P; Hozak, RR; Kim, JH; Lee, DH; Lee, KH; Mao, H; Park, K; Paz-Ares, LG; Planchard, D; Wijayawardana, SR; Yang, JC; Yu, HA, 2021)	0.85
" However, despite the generally favorable outcomes associated with osimertinib, rapid development and deployment of any new drug increases the risk of unforeseen adverse effects."	( Myositis - A common but underreported adverse effect of osimertinib: Case series and review of the literature. Beutler, BD; Islam, RX; Krishan, R; Parafianowicz, P; Singh, T, 2020)	1.04
"Myositis is a serious and potentially underreported adverse effect of osimertinib."	( Myositis - A common but underreported adverse effect of osimertinib: Case series and review of the literature. Beutler, BD; Islam, RX; Krishan, R; Parafianowicz, P; Singh, T, 2020)	1.04
"Post hoc analyses of cardiac data from (1) studies in patients with advanced non-small-cell lung cancer, FLAURA (osimertinib, n = 279; comparator EGFR-TKI, n = 277) and AURA3 (osimertinib, n = 279; chemotherapy, n = 140), and (2) a pooled data set of patients treated with osimertinib 80 mg from across the clinical trial program (n = 1,142), including cardiac failure-related adverse events and left ventricular ejection fraction (LVEF) reductions."	( Cardiac Safety of Osimertinib: A Review of Data. Atuah, KN; Ewer, MS; Tekumalla, SH; Walding, A, 2021)	1.17
" The pooled analysis of objective response rate (ORR), disease controlled rate (DCR), progressionfree survival (PFS), overall survival (OS) and adverse events (AEs) were performed using STATA12."	( The efficacy and safety of Osimertinib in advanced non-small cell lung cancer patients with Thr790Met resistance mutations: a systematic review and meta-analysis. Cao, S; Cui, S; Huang, X; Huo, X; Li, Y; Liu, L; Wang, N; Zhang, Y; Zhou, R, 2021)	0.92
" Grade 3-4 adverse events were seen in 11."	( The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study. Açıkgöz, Ö; Ak, N; Aydıner, A; Ayhan, M; Bahçeci, A; Başoğlu, T; Bilgin, B; Bilici, A; Can, A; Caner, B; Demiray, AG; Demirkazık, A; Demirkıran, A; Erol, C; Gökmen, İ; Gülmez, A; Gürbüz, M; Güven, DC; Hizal, M; İriağaç, Y; Karakaş, Y; Mandel, NM; Paksoy, N; Paydaş, S; Şakalar, T; Şendur, MAN; Sezer, A; Shbair, A; Tatlı, AM; Yalçın, B; Yücel, Ş; Yumuk, PF; Zeynelgil, E, 2022)	0.99
" Adverse reactions were collected and documented during the treatment."	( Clinical outcomes and safety of osimertinib plus anlotinib for patients with previously treated EGFR T790M-positive NSCLC: A retrospective study. Gong, Q; Jiang, HT; Li, B; Li, HF; Li, W; Qie, HL; Zhou, B, 2022)	1
" Safety profile suggested that the most common adverse reactions of the patients with NSCLC who received anlotinib plus osimertinib were hypertension (63."	( Clinical outcomes and safety of osimertinib plus anlotinib for patients with previously treated EGFR T790M-positive NSCLC: A retrospective study. Gong, Q; Jiang, HT; Li, B; Li, HF; Li, W; Qie, HL; Zhou, B, 2022)	1.21
"Although phase 3 clinical trials play an important role in understanding the effectiveness and give insights on side-effect profiles, real-world studies can show the real risk of cardiotoxicity more accurately and realistically."	( Investigating the efficacy of osimertinib and crizotinib in phase 3 clinical trials on anti-cancer treatment-induced cardiotoxicity: are real-world studies the way forward? Dorak, MT; Elkonaissi, I; Foreman, E; Kobat, H; Nabhani-Gebara, S; O'Brien, M, 2023)	1.2
" Primary safety variables included treatment-emergent adverse events (TEAEs), serious adverse events (SAEs), and adverse events (AEs) leading to discontinuation/interruption/change (D/I/C) of drug dose, and AEs of special interest (AESIs)."	( Safety of osimertinib in adult patients with metastatic epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer: Results from a Phase IV study in India. Batra, U; Dabkara, D; Limaye, S; Maddu, VK; Malik, PS; Noronha, V; Rajappa, S, 2022)	1.12
"Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) first-line therapy, has shown good clinical outcomes in non-small cell lung cancer (NSCLC), but some serious adverse events such as cardiotoxicity have also been reported."	( Aumolertinib Effectively Reduces Clinical Symptoms of an EGFR L858R-Mutant Non-Small Cell Lung Cancer Case Coupled With Osimertinib-Induced Cardiotoxicity: Case Report and Review. Liu, H; Yang, J; Zhang, Q, 2022)	2.37
" Additional outcome was the incidence of adverse event."	( Efficacy and safety of osimertinib for patients with EGFR-mutated NSCLC: a systematic review and meta-analysis of randomized controlled studies. Deng, J; Huang, Q; Li, L; Li, Z; Liu, L; Sun, J; Wei, W; Yan, F, 2022)	1.03
" Our study was to explore the adverse events (AEs) caused by osimertinib through data mining of the US FDA Adverse Event Reporting System (FAERS), and provide reference for clinical safety."	( A real-world pharmacovigilance study of FDA Adverse Event Reporting System (FAERS) events for osimertinib. Li, F; Li, J; Shu, Y; Yin, Y; Zhu, J, 2022)	1.18
"Potential novel strategies for adverse event (AE) management of osimertinib therapy, including therapeutic drug monitoring and the use of biomarkers, have not yet been fully investigated."	( Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study. Chishima, H; Hakamata, J; Ikemura, S; Ishikawa, E; Jibiki, A; Kasai, H; Kawada, I; Kawazoe, H; Kimura, M; Kuniyoshi, O; Muramatsu, H; Nakada, H; Nakajima, H; Nakamura, T; Nakaya, N; Soejima, K; Suehiro, N; Suzuki, S; Terai, H; Yasuda, H; Yokoyama, Y, 2023)	1.38
" Adverse events of grade 3 or higher were similar in the two groups (25."	( Real-world data on efficacy and safety of osimertinib in non-small cell lung cancer patients with EGFR T790M mutation detected by first and repeat rebiopsy. Bai, R; Ren, X; Wang, H; Wang, Y; Xu, K; Xu, Y; Zhang, H; Zhang, Z; Zou, Y, 2023)	1.17
" The common adverse events were mainly grade 1-2, and only three cases (11."	( Efficacy and safety of osimertinib plus anlotinib in advanced non-small-cell lung cancer patients after drug resistance. Chen, T; Hu, X; Liu, Y; Shi, Y; Wang, L; Wang, M; Zhao, J, 2023)	1.22
"Osimertinib combined with anlotinib as three or more lines of treatment in advanced NSCLC was effective and adverse events were tolerable."	( Efficacy and safety of osimertinib plus anlotinib in advanced non-small-cell lung cancer patients after drug resistance. Chen, T; Hu, X; Liu, Y; Shi, Y; Wang, L; Wang, M; Zhao, J, 2023)	2.66
"For patients with EGFR-mutant NSCLC with an acquired RET fusion as a mechanism of EGFR inhibitor resistance, the addition of selpercatinib to osimertinib was feasible and safe and offered clinical benefit, supporting the prospective evaluation of this combination."	( Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers. Awad, M; Clifford, S; Drilon, A; Goldman, JW; Hanley, MP; Harada, G; Kherani, J; Kuo, CS; Nechushtan, H; Oxnard, GR; Patel, JD; Rajappa, S; Rotow, J; Santucci, A; Scheffler, M; Silva, L; Tupper, R; Yu, H, 2023)	2.55
" Most adverse events (AEs) were first reported within 12 months of starting treatment (osimertinib 97%, placebo 86%)."	( Three-Year Safety, Tolerability, and Health-Related Quality of Life Outcomes of Adjuvant Osimertinib in Patients With Resected Stage IB to IIIA EGFR-Mutated NSCLC: Updated Analysis From the Phase 3 ADAURA Trial. Albayaty, M; Chen, J; Choi, JH; de Marinis, F; Fidler, MJ; Goldman, JW; Grohé, C; Herbst, RS; John, T; Kato, T; Majem, M; Melotti, B; Shepherd, FA; Sriuranpong, V; Stachowiak, M; Su, WC; Taggart, S; Tsuboi, M; Wang, Q; Wu, YL, 2023)	1.35
" Meta-analysis of proportions was conducted to calculate the pooled rate of overall response rate (ORR), disease control rate (DCR), one-year overall survival (OS), and adverse events (AEs)."	( Efficacy and safety of osimertinib for leptomeningeal metastases from EGFR-mutant non-small cell lung cancer: a pooled analysis. Cai, L; Chen, L; Hong, W; Hu, Q; Lai, M; Li, J; Li, S; Shan, C; Tian, X; Wang, H; Wen, L; Xie, Z; Yang, Y; Ye, M; Zhen, J; Zhou, C; Zhou, J; Zhou, Z, 2023)	1.22

Excerpt	Reference	Relevance
" Distribution was extensive and clearance low to moderate, resulting in a mean half-life of 48."	( Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies. Brown, KH; Cantarini, M; Dickinson, PA; Felip, E; Jänne, PA; Kim, DW; Kim, SW; Leese, P; Ohe, Y; Planchard, D; Ranson, M; Vishwanathan, K, 2016)	1.88
"To develop a population (pop) pharmacokinetic (PK) model for osimertinib (AZD9291) and its metabolite (AZ5104) and investigate the exposure-response relationships for selected efficacy and safety parameters."	( Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer. Brown, K; Cantarini, M; Comisar, C; Cox, E; de Greef, R; Maringwa, J; Vishwanathan, K; Witjes, H, 2017)	0.95
" The method was successfully applied in a pharmacokinetic study of osimertinib after oral administration of osimertinib (4."	( Development and Validation of a Rapid and Sensitive LC-MS/MS Method for the Pharmacokinetic Study of Osimertinib in Rats. Deng, Z; Mu, Y; Sun, P; Xiong, S; Xue, M, 2017)	0.91
" Here we developed the first computational strategy to explore pharmacokinetic and drug interaction effects in evolutionary models of cancer progression, a crucial step towards making clinically relevant predictions."	( Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution. Chakrabarti, S; Michor, F, 2017)	0.46
" Blood samples were collected at prespecified time points for pharmacokinetic analyses."	( The Effect of Food or Omeprazole on the Pharmacokinetics of Osimertinib in Patients With Non-Small-Cell Lung Cancer and in Healthy Volunteers. Bui, K; Cassier, PA; Dickinson, PA; Greystoke, A; Lisbon, E; Moreno, V; Plummer, R; So, K; Thomas, K; Vishwanathan, K; Weilert, D; Yap, TA, 2018)	0.72
" This popular strategy is deemed to improve the pharmacokinetic characteristics of the original drugs."	( Metabolism and pharmacokinetic study of deuterated osimertinib. Bao, S; Chen, X; Dahar, MR; Ji, K; Li, X; Lin, N; Niu, C; Tang, Z; Wu, Y; Yu, L; Zeng, K; Zhan, X; Zhou, S, 2023)	1.16
"Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety."	( Molecular Docking, Pharmacokinetic and Molecular Simulation Analysis of Novel Mono-Carbonyl Curcumin Analogs as L858R/T790M/C797S Mutant EGFR Inhibitors. Bhandari, SV; Chaudhari, SY; Kuthe, PV; Nagras, OG; Patil, SM; Sarkate, AP; Surve, SV, 2023)	0.91

Excerpt	Reference	Relevance
" The efficacy of brigatinib is enhanced markedly by combination with anti-EGFR antibody because of the decrease of surface and total EGFR expression."	( Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer. Araki, M; Fujita, N; Inase, N; Kamada, M; Katayama, R; Okuno, Y; Sato, S; Uchibori, K, 2017)	0.7
" A combination of in vitro data, clinical pharmacokinetic data, and drug-drug interaction (DDI) data of osimertinib in oncology patients were used to develop the physiologically based pharmacokinetic (PBPK) model and verify the DDI data of osimertinib."	( Development, Verification, and Prediction of Osimertinib Drug-Drug Interactions Using PBPK Modeling Approach to Inform Drug Label. Ballard, P; Pilla Reddy, V; Sharma, P; Vishwanathan, K; Walker, M, 2018)	0.96
" Our findings indicate that osimertinib, rather than gefitinib combined with anti-PD-L1 treatment could lead to lung injury in an EGFR mutated tumor-bearing mouse model."	( Impact of EGFR-TKIs combined with PD-L1 antibody on the lung tissue of EGFR-driven tumor-bearing mice. Han, R; Jia, Y; Jiang, T; Li, X; Liu, S; Liu, Y; Qiao, M; Ren, S; Su, C; Zhao, C; Zhao, S; Zhou, C, 2019)	0.81
" The multi-arm phase Ib TATTON study (NCT02143466) was designed to assess the safety and tolerability of osimertinib in combination with other targeted therapies: selumetinib (MEK1/2 inhibitor), savolitinib (MET-TKI), or durvalumab [anti-programmed cell death ligand 1 (anti-PD-L1) monoclonal antibody]."	( TATTON: a multi-arm, phase Ib trial of osimertinib combined with selumetinib, savolitinib, or durvalumab in EGFR-mutant lung cancer. Ahn, MJ; Frigault, MM; Ghiorghiu, D; Goto, K; Horn, L; Kim, SW; Mann, H; Ohe, Y; Oxnard, GR; Ramalingam, SS; Saka, H; Thress, KS; Vishwanathan, K; Yang, JC; Yu, H, 2020)	1.04
"To explore the therapeutic effects and prognosis of osimertinib combined with docetaxel for non-small cell lung cancer (NSCLC)."	( Analysis of efficacy and prognosis of Osimertinib combined with docetaxel for non-small cell lung cancer. Huang, Y; Shi, Y; Yin, X; Zhang, Q, )	0.65
" Patients in the control group took osimertinib tablets, while patients in the drug combination group were given intravenous docetaxel in addition to the oral administration of osimertinib."	( Analysis of efficacy and prognosis of Osimertinib combined with docetaxel for non-small cell lung cancer. Huang, Y; Shi, Y; Yin, X; Zhang, Q, )	0.68
"The overall response rate (RR) and disease control rate (DCR) in the drug combination group were 25."	( Analysis of efficacy and prognosis of Osimertinib combined with docetaxel for non-small cell lung cancer. Huang, Y; Shi, Y; Yin, X; Zhang, Q, )	0.4
"The therapeutic effect of osimertinib combined with docetaxel is better than that of osimertinib alone, but the toxic and side effects of combined use are significantly higher, suggesting that enteral administration should be conducted during the medication period."	( Analysis of efficacy and prognosis of Osimertinib combined with docetaxel for non-small cell lung cancer. Huang, Y; Shi, Y; Yin, X; Zhang, Q, )	0.7
" In AXL-low-expressing EGFRmut-LC cell-derived xenograft and patient-derived xenograft models, transient IGF-1R inhibition combined with continuous osimertinib treatment could eradicate tumors and prevent regrowth even after the cessation of osimertinib."	( Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer. Arai, S; Atagi, S; Fukuda, K; Han, X; Hanayama, R; Ishimura, A; Kaira, K; Kita, K; Matsumoto, I; Matsumoto, K; Nishiyama, A; Ohtsubo, K; Suzuki, T; Takayama, K; Takeuchi, S; Taniguchi, H; Taniguchi, Y; Tanimoto, A; Terashima, M; Uehara, H; Wang, R; Wang, W; Yamada, T; Yamano, T; Yamashita, K; Yano, S; Yoshimura, A, 2020)	1.02
"This is the first study to explore the efficacy and safety of osimertinib combined with platinum-based chemotherapy in previously untreated NSCLC patients with EGFR-sensitizing mutations."	( A Phase II Study of Osimertinib Combined With Platinum Plus Pemetrexed in Patients With EGFR-Mutated Advanced Non-Small-cell Lung Cancer: The OPAL Study (NEJ032C/LOGIK1801). Asahina, H; Isobe, T; Kagamu, H; Kikuchi, T; Kobayashi, K; Maemondo, M; Morita, S; Oizumi, S; Okamoto, I; Seike, M; Sugio, K; Takahashi, K; Tanaka, K, 2021)	1.19
" The aim of this study was to investigate the efficacy and safety of osimertinib combined with bevacizumab for LM from epidermal growth factor receptor mutation (EGFRm) NSCLC."	( Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial. Cai, J; Huang, L; Liu, AW; Lu, ZQ; Wang, X; Wei, JP; Zeng, ZM, 2021)	2.3
"We conducted a phase II single-arm prospective clinical trial of EGFRm NSCLC with LM treated with osimertinib combined with bevacizumab."	( Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial. Cai, J; Huang, L; Liu, AW; Lu, ZQ; Wang, X; Wei, JP; Zeng, ZM, 2021)	2.28
"Osimertinib combined with bevacizumab is an appropriate treatment option for patients with LM from EGFRm NSCLC."	( Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial. Cai, J; Huang, L; Liu, AW; Lu, ZQ; Wang, X; Wei, JP; Zeng, ZM, 2021)	3.51
"SIGNIFICANT FINDINGS OF THE STUDY: To date, there is no prospective clinical study on the treatment of osimertinib combined with bevacizumab in EGFRm NSCLC with LM."	( Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial. Cai, J; Huang, L; Liu, AW; Lu, ZQ; Wang, X; Wei, JP; Zeng, ZM, 2021)	2.28
" Osimertinib combined with bevacizumab is an appropriate treatment option for patients with LM from EGFRm NSCLC."	( Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial. Cai, J; Huang, L; Liu, AW; Lu, ZQ; Wang, X; Wei, JP; Zeng, ZM, 2021)	2.97
" This case suggests the re-challenge of the first-generation EGFR-TKIs combined with bevacizumab may overcome the tumor resistance and prolong survival of NSCLC patient."	( Bevacizumab Combined with Icotinib Overcomes Osimertinib Resistance in a Patient of Non-Small Cell Lung Cancer. Ji, YX; Mu, XY; Sun, L; Zhang, L, 2019)	0.77
"The study was designed to investigate the safety of ramucirumab administered in combination with erlotinib or osimertinib for patients with untreated EGFR-mutated non-small cell lung cancer (NSCLC) and asymptomatic brain metastases, a patient subgroup in which these regimens have remained untested."	( Phase 1b study of ramucirumab in combination with erlotinib or osimertinib for untreated EGFR-mutated non-small cell lung cancer patients with asymptomatic brain metastases. Atagi, S; Daga, H; Izumi, M; Kaneda, H; Kawaguchi, T; Matsumoto, Y; Mitsuoka, S; Nakahama, K; Nakatani, Y; Ogawa, K; Okada, A; Okishio, K; Sawa, K; Tani, Y, 2021)	1.07
"Ramucirumab in combination with erlotinib or osimertinib showed safety for EGFR-mutated NSCLC with brain metastases."	( Phase 1b study of ramucirumab in combination with erlotinib or osimertinib for untreated EGFR-mutated non-small cell lung cancer patients with asymptomatic brain metastases. Atagi, S; Daga, H; Izumi, M; Kaneda, H; Kawaguchi, T; Matsumoto, Y; Mitsuoka, S; Nakahama, K; Nakatani, Y; Ogawa, K; Okada, A; Okishio, K; Sawa, K; Tani, Y, 2021)	1.12
" There are limited clinical trial data describing the efficacy of osimertinib combined with MET inhibition in EGFR T790M-mutant NSCLC patients with Met amplification."	( Dramatic response to osimertinib combined with crizotinib in EGFR T790 M mutation only in blood and Met amplification only in tumor tissue expressive non-small cell lung cancer: A case report. Chen, K; Gui, Q; Li, D; Shen, M; Xu, C, 2021)	1.18
"A non-smoking 53-year-old male patient with lung adenocarcinoma underwent gefitinib, afatinib, and osimertinib combined with crizotinib treatment and developed different EGFR resistance mutations."	( Dramatic response to osimertinib combined with crizotinib in EGFR T790 M mutation only in blood and Met amplification only in tumor tissue expressive non-small cell lung cancer: A case report. Chen, K; Gui, Q; Li, D; Shen, M; Xu, C, 2021)	1.16
"The patient received systemic treatments, including chemotherapy, gefitinib, afatinib, and osimertinib combined with crizotinib."	( Dramatic response to osimertinib combined with crizotinib in EGFR T790 M mutation only in blood and Met amplification only in tumor tissue expressive non-small cell lung cancer: A case report. Chen, K; Gui, Q; Li, D; Shen, M; Xu, C, 2021)	1.16
"Although osimertinib combined with crizotinib therapy showed dramatic tumor shrinkage in both the primary tumor and bone metastasis to an EGFR T790M-mutant NSCLC patient with MET amplification, the progression-free survival (PFS) was only two months."	( Dramatic response to osimertinib combined with crizotinib in EGFR T790 M mutation only in blood and Met amplification only in tumor tissue expressive non-small cell lung cancer: A case report. Chen, K; Gui, Q; Li, D; Shen, M; Xu, C, 2021)	1.36
" In conclusion, targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer may be a novel therapeutic option."	( Targeting ROR1 in combination with osimertinib in EGFR mutant lung cancer cells. Fukazawa, T; Harada, D; Ikeda, T; Kiura, K; Miyake, N; Nagasaki, Y; Nakagawa, N; Nakanishi, H; Ochi, N; Takeyama, M; Takigawa, N; Yamane, H; Yokota, E, 2021)	1.15
"Pemetrexed (800 mg day 1), cis-platinum (40 mg day 1-3) combined with bevacizumab (400 mg day 1) every 3 weeks were administered to the patient."	( Erlotinib combined with bevacizumab and chemotherapy in first line osimertinib-resistant NSCLC patient with leptomeningeal metastasis: A case report. Li, M; Luo, N; Qi, Y; Wang, M; Zhu, F, 2021)	0.86
" Herein, we report four cases of T790M-negative EGFRm NSCLC patients treated with osimertinib combined with systemic chemotherapy, who progressed on prior EGFR TKI and developed LM with extracranial lesions."	( Osimertinib Combined with Systemic Chemotherapy for EGFR Mutant, T790M-Negative, Non-Small Cell Lung Cancer Patients Who Develop Leptomeningeal Metastases with Extracranial Progression to Prior EGFR TKI. Ahn, JS; Ahn, MJ; Hong, J; Jo, H; Jung, HA; Kim, H; Kim, HR; Lee, SH; Park, S, 2023)	2.58
"To explore the effects of osimertinib combined with pulmonary rehabilitation and health care training on pulmonary function, complications, and the quality of life (QOL) in patients after radical resection of lung cancer."	( Effects of Osimertinib Combined With Pulmonary Rehabilitation and Health Care Training on Pulmonary Function, Complications, and Quality of Life in Patients After Radical Resection of Lung Cancer. Guo, R; Xu, H; Yang, Y, 2022)	1.41
"Validation studies with cellular toxicity assays confirmed that osimertinib in combination with ARS-1620, a KRAS G12C inhibitor, and BAY-293, a pan-KRAS inhibitor, showed a synergistic effect on decreasing cellular proliferation by acting on mutant KRAS."	( Multiscale Analysis and Validation of Effective Drug Combinations Targeting Driver KRAS Mutations in Non-Small Cell Lung Cancer. Aalinkeel, R; Battaglia, S; Bruggemann, L; Falls, Z; Mahajan, SD; Mangione, W; Samudrala, R; Schwartz, SA, 2023)	1.15
" Mechanistically, we confirmed that MYC binds to the promoter of AXL to promote its transcription in NSCLC cells, and we demonstrated that anlotinib combined with osimertinib treatment enhances the anti-tumor effect by inactivating the c-MET/MYC/AXL axis to reverse osimertinib resistance in NSCLC."	( Anlotinib combined with osimertinib reverses acquired osimertinib resistance in NSCLC by targeting the c-MET/MYC/AXL axis. Kong, Z; Lei, T; Wang, Z; Wei, C; Xu, T; Zhang, N; Zou, X, 2023)	1.41
" We present a case of severe thrombocytopenia in a 70-year-old NSCLC patient caused by osimertinib combined with sitagliptin."	( Successful osimertinib rechallenge after severe thrombocytopenia caused by osimertinib combined with sitagliptin: a case report. Chen, S; He, L; Huang, M; Tan, X; Zhang, X, 2023)	1.52
" The patient was diagnosed with stage IIIA lung adenocarcinoma, and genetic testing revealed EGFR exon 19 deletion mutation combined with Tumor Protein p53 (TP53) mutation."	( Successful neoadjuvant treatment of EGFR exon 19 deletion combined with TP53 mutation in non-small cell lung cancer using aumolertinib after osimertinib-induced myocardial damage: a case report and literature review. Lai, Q; Li, J; Qiu, X; Tang, X; Zhang, G; Zhang, X, 2023)	1.11
" The patients were initially treated with Aumolertinib combination with Bevacizumab; among which, one case was discontinued Bevacizumab due to bleeding risk after treatment for three months."	( [Initial Treatment of Aumolertinib in Combination with Bevacizumab for Advanced NSCLC with Primary EGFR T790M Mutation: A Report of Three Cases and Literature Review]. Meng, F; Yang, X; Zhong, D, 2023)	0.91
"The efficacy and safety of osimertinib combined with bevacizumab in non-small cell lung cancer (NSCLC) patients with brain metastasis harboring epidermal growth factor receptor (EGFR) mutations have not been fully studied."	( Osimertinib combined with bevacizumab as the first-line treatment in non-small cell lung cancer patients with brain metastasis harboring epidermal growth factor receptor mutations. Ji, Y; Liu, F; Liu, X; Nie, K; You, Y; Zhang, L, 2023)	2.65
"Osimertinib combined with bevacizumab shows promising results in EGFR-mutated NSCLC patients with brain metastasis, and the side effects are tolerable."	( Osimertinib combined with bevacizumab as the first-line treatment in non-small cell lung cancer patients with brain metastasis harboring epidermal growth factor receptor mutations. Ji, Y; Liu, F; Liu, X; Nie, K; You, Y; Zhang, L, 2023)	3.8

Excerpt	Reference	Relevance
" Bioavailability study (NCT01951599): single-dose PK of osimertinib (20 mg) was determined in healthy volunteers with administration of capsule, solution, or tablet formulations fasted, and as a tablet in the fed and fasted state."	( Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies. Brown, KH; Cantarini, M; Dickinson, PA; Felip, E; Jänne, PA; Kim, DW; Kim, SW; Leese, P; Ohe, Y; Planchard, D; Ranson, M; Vishwanathan, K, 2016)	2.12
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
" Herein, we report an orally bioavailable EGFR PROTAC, HJM-561, which selectively degrades the EGFR C797S-containing triple mutants."	( HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations. Chen, J; Chen, Y; Du, Y; Li, Y; Lu, X; Wang, Y; Wang, Z; Ye, G; Zhang, G; Zhang, L, 2022)	0.95

Excerpt	Relevance	Reference
" In vivo, concomitant dosing of AZD9291 with selumetinib caused regression of AZD9291-resistant tumors in an EGFRm/T790M transgenic model."	( Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models. Ahdesmaki, MJ; Ahmed, A; Al-Kadhimi, KJ; Barnes, CH; Beran, G; Brown, H; Cross, DA; Dougherty, B; Dry, JR; Eberlein, CA; Fisher, PR; Ichihara, E; Lai, Z; Markovets, AA; Meador, CB; O'Brien, EL; Pao, W; Ratcliffe, LE; Ross, SJ; Smith, PD; Spitzler, P; Stetson, D; Thress, KS, 2015)	0.42
" Plasma was collected prior to AZD9291 dosing but following clinical progression on a previous EGFR-tyrosine kinase inhibitor (TKI)."	( EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291. Barrett, JC; Brant, R; Brown, H; Cantarini, M; Carr, TH; Dearden, S; Hammett, T; Jenkins, S; Thress, KS, 2015)	0.42
" Osimertinib PK was evaluated to define the dose and dosing interval, whether a fixed-dosing approach can be used globally, and the impact of formulation and food on exposure."	( Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies. Brown, KH; Cantarini, M; Dickinson, PA; Felip, E; Jänne, PA; Kim, DW; Kim, SW; Leese, P; Ohe, Y; Planchard, D; Ranson, M; Vishwanathan, K, 2016)	2.79
" Osimertinib plasma concentrations are sustained throughout the dosing period, which is considered optimal for efficacy."	( Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies. Brown, KH; Cantarini, M; Dickinson, PA; Felip, E; Jänne, PA; Kim, DW; Kim, SW; Leese, P; Ohe, Y; Planchard, D; Ranson, M; Vishwanathan, K, 2016)	2.79
" Osimertinib was dosed in xenografted models of EGFR-driven cancers."	( Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic-Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104. Ashton, S; Ballard, P; Cross, D; Mellor, MJ; Powell, SJ; Yates, JW, 2016)	1.56
"PK, safety and efficacy data were collected from two non-small cell lung cancer (NSCLC) patient studies (n = 748) and one healthy volunteer study (n = 32), after single or multiple once-daily dosing of 20-240 mg osimertinib."	( Population pharmacokinetics and exposure-response of osimertinib in patients with non-small cell lung cancer. Brown, K; Cantarini, M; Comisar, C; Cox, E; de Greef, R; Maringwa, J; Vishwanathan, K; Witjes, H, 2017)	0.89
" As this clinical entity is underrepresented in clinical trials, the practicability of plasma EGFR testing and the optimal dose-response relationship of osimertinib in T790M-positive lung cancer complicated with LM deserves further exploration."	( Sustained response to standard dose osimertinib in a patient with plasma T790M-positive leptomeningeal metastases from primary lung adenocarcinoma. Chan, OS; Leung, WK; Yeung, RM, 2017)	0.93
" Our results suggest that the schedules used in the three trial arms have almost identical efficacies, but slight modifications in the dosing frequencies of the two drugs can significantly increase tumor cell eradication."	( Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution. Chakrabarti, S; Michor, F, 2017)	0.46
"Fifty-two patients in the CYP3A study (pharmacokinetic [PK] analysis, n = 49), and 44 patients in the BCRP study were dosed (PK analysis, n = 44)."	( Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin. Aransay, NR; Arkenau, T; Bui, K; Dickinson, PA; Harvey, RD; Isambert, N; Lee, JS; So, K; Thomas, K; Vansteenkiste, J; Vishwanathan, K; Weilert, D, 2018)	0.79
" Primary endpoints were safety and tolerability, which were assessed in all dosed patients."	( Osimertinib plus savolitinib in patients with EGFR mutation-positive, MET-amplified, non-small-cell lung cancer after progression on EGFR tyrosine kinase inhibitors: interim results from a multicentre, open-label, phase 1b study. Ahn, MJ; Cantarini, M; Cho, BC; Frewer, P; Han, JY; Kim, SW; Kowalski, D; Lee, JS; Mellemgaard, A; Orlov, S; Ottesen, L; Ou, X; Oxnard, G; Sequist, LV; Su, WC; Verheijen, RB; Yang, JC; Yu, H, 2020)	2
"Patients with EGFR-mutated advanced NSCLC with LM were included: cohort 1, patients with LM who were treated with osimertinib with CSF and plasma genotyping performed before the first dosing of osimertinib (baseline, n = 45); cohort 2, CSF genotyping on progression on osimertinib and development of LM (the progression event on osimertinib is the diagnosis of LM, n = 35)."	( Genotyping of Cerebrospinal Fluid Associated With Osimertinib Response and Resistance for Leptomeningeal Metastases in EGFR-Mutated NSCLC. Jiang, BY; Li, YS; Tu, HY; Wu, YL; Xu, CR; Yang, JJ; Yang, XR; Zheng, MM; Zhou, Q, 2021)	1.08
" The dosage of Osimertinib was reduced in 2 cases due to adverse reactions, while other adverse reactions were improved after symptomatic treatment."	( Effect of osimertinib in treating patients with first-generation EGFR-TKI-resistant advanced non-small cell lung cancer and prognostic analysis. Guo, RTW; Guo, Y; Li, J; Wang, R; Yang, Y; Zhu, H, )	0.89
" However, the efficacy and optimal dosage of osimertinib in the treatment of NSCLC patients with LM who harbor uncommon EGFR mutations have yet to be fully investigated."	( A non-small cell lung cancer (NSCLC) patient with leptomeningeal metastasis harboring rare epidermal growth factor receptor (EGFR) mutations G719S and L861Q benefited from doubling dosage of osimertinib: a case report. Cai, LB; Chen, ZJ; Hong, WP; Lai, MY; Lin, T; Liu, D; Shan, CG; Wang, H; Wen, L; Zhang, L; Zhen, JJ; Zou, X, 2021)	1.07
" Here we present an integrated computational modeling and experimental approach to identify an optimal dosing schedule for osimertinib and dacomitinib combination therapy."	( Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer. Chakrabarti, S; Frisco-Cabanos, H; Hata, A; Makhnin, A; McDonald, TO; Michor, F; Napoli, C; Poels, KE; Schoenfeld, AJ; Shi, M; Tan, W; Tobi, Y; Wang, Y; Weinrich, SL; Yu, HA, 2021)	1.07
" We found that the survival in RA-treated NSCLC cells was significantly decreased by treatment with 500 nM AZD3759 and osimertinib at the RA dosage of 8 Gy."	( AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1. Deng, Q; Ma, S; Mao, Y; Yin, W; Yu, Q; Zhang, K; Zhao, R, 2022)	0.93
" The concurrent combination treatment was well tolerated by the patient through dosing modification and supportive medical care."	( Combined targeting of EGFR and BRAF triggers regression of osimertinib resistance by using osimertinib and vemurafenib concurrently in a patient with heterogeneity between different lesions. Guo, Y; Ma, K; Qiu, S; Sun, C; Sun, M; Wang, X; Xu, Y; Zhao, R; Zhu, W, 2022)	0.96
", And further explored the therapeutic potential of osimertinib combined with T-DM1 at different dosing times."	( Construction of IMMS Containing Multi-site Liposomes for Dynamic Monitoring of Blood CTC in Patients with Osimertinib-resistant Non-small-cell Lung Cancer and its Mechanism. Chen, X; Chen, Y; Li, B; Liang, J; Lu, Y; Luo, L; Ning, Y; Qiu, Y, 2023)	1.37
" Our case describes a significative response with Osimertinib despite the change in dosage and schedule in a patient with MCS."	( Undertreatment with Osimertinib in patient with multiple chemical sensitivity. A case report. Angelini, F; Gozzi, E; Rossi, L; Taccogna, S, )	0.71
" An open-label, non-randomized phase 1 study was conducted in Taiwan, in which 13 patients received DS-1205c monotherapy at a dosage of 200, 400, 800, or 1200 mg twice daily for 7 days, followed by combination treatment with DS-1205c (same doses) plus osimertinib 80 mg once daily in 21-day cycles."	( Evaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study. Chang, GC; Chen, WC; Chiu, CH; Crawford, N; Hong, Y; Hsia, TC; Hsu, C; Lee, KY; McGill, J; Saintilien, C; Shiah, HS; Su, WC; Takayama, G; Terakawa, H; Uno, M; Yang, JC, 2023)	1.32
"0%) received osimertinib as ≥ 2nd-line treatment for LM, either at a dosage of 80 mg (161/353, 45."	( Efficacy and safety of osimertinib for leptomeningeal metastases from EGFR-mutant non-small cell lung cancer: a pooled analysis. Cai, L; Chen, L; Hong, W; Hu, Q; Lai, M; Li, J; Li, S; Shan, C; Tian, X; Wang, H; Wen, L; Xie, Z; Yang, Y; Ye, M; Zhen, J; Zhou, C; Zhou, J; Zhou, Z, 2023)	1.59

Role	Description
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
epidermal growth factor receptor antagonist	An antagonist at the epidermal growth factor receptor.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
indoles	Any compound containing an indole skeleton.
aminopyrimidine	A member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives.
biaryl	An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond.
secondary amino compound	A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
tertiary amino compound	A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
monomethoxybenzene	Compounds containing a benzene skeleton substituted with one methoxy group.
acrylamides	An enamide which is acrylamide or a derivative of acrylamide obtained by replacement of one or more of its hydrogens.
substituted aniline
secondary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Disease	1278	231
Diseases of signal transduction by growth factor receptors and second messengers	262	31
Signaling by ERBB2 in Cancer	16	10
Drug resistance in ERBB2 KD mutants	4	6
Resistance of ERBB2 KD mutants to osimertinib	3	1

Protein Targets (322)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
PPM1D protein	Homo sapiens (human)	Potency	8.2891	0.0052	9.4661	32.9993	AID1347411
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	10.6840	0.0123	7.9835	43.2770	AID1645841
G	Vesicular stomatitis virus	Potency	26.8370	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2D6	Homo sapiens (human)	Potency	23.9185	0.0010	8.3798	61.1304	AID1645840
Interferon beta	Homo sapiens (human)	Potency	12.9261	0.0033	9.1582	39.8107	AID1347411; AID1645842
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	26.8370	0.0123	8.9648	39.8107	AID1645842
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	2.5359	0.0096	10.5250	35.4813	AID1479145; AID1479148
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	26.8370	0.0123	8.9648	39.8107	AID1645842
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	26.8370	0.0123	8.9648	39.8107	AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Histone deacetylase 3	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0004	0.6196	10.0000	AID1720096
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50 (µMol)	3.9800	0.0031	2.1602	9.6000	AID1872409
Epidermal growth factor receptor	Homo sapiens (human)	GI50	0.6719	0.0003	0.6494	3.5000	AID1481308; AID1481309; AID1481310; AID1481312; AID1481313; AID1481314; AID1481316; AID1481317; AID1481318; AID1481319; AID1481353; AID1481354; AID1481355; AID1481356; AID1481357; AID1481358; AID1740136; AID1740137; AID1740138; AID1740141
Epidermal growth factor receptor	Homo sapiens (human)	IC50 (µMol)	3.2863	0.0000	0.5369	10.0000	AID1167101; AID1167102; AID1167103; AID1289545; AID1289546; AID1289550; AID1289551; AID1289554; AID1289555; AID1291334; AID1291335; AID1291336; AID1298660; AID1298661; AID1321092; AID1321093; AID1321095; AID1359368; AID1359369; AID1365584; AID1365586; AID1365587; AID1382532; AID1382533; AID1382534; AID1382535; AID1389856; AID1389857; AID1389858; AID1390633; AID1390635; AID1390636; AID1390638; AID1391281; AID1391283; AID1391284; AID1412316; AID1412317; AID1423824; AID1423825; AID1434568; AID1434569; AID1441910; AID1441911; AID1441912; AID1445468; AID1445469; AID1445470; AID1458976; AID1458977; AID1458978; AID1461711; AID1461712; AID1469776; AID1469777; AID1483366; AID1483367; AID1483368; AID1483369; AID1484432; AID1484433; AID1484434; AID1497678; AID1497679; AID1497680; AID1497681; AID1497691; AID1497692; AID1497693; AID1497694; AID1519413; AID1519414; AID1580125; AID1580126; AID1580127; AID1583836; AID1583837; AID1583838; AID1585296; AID1585297; AID1585298; AID1585919; AID1585920; AID1589887; AID1612545; AID1612546; AID1616559; AID1616561; AID1617466; AID1617467; AID1617468; AID1656714; AID1656715; AID1664394; AID1664395; AID1664396; AID1673934; AID1676511; AID1676512; AID1676513; AID1676514; AID1676515; AID1702615; AID1702616; AID1708236; AID1708237; AID1708238; AID1709313; AID1709314; AID1715789; AID1715791; AID1717446; AID1724046; AID1730451; AID1730452; AID1730858; AID1738670; AID1740144; AID1740145; AID1740146; AID1740147; AID1756967; AID1756968; AID1762240; AID1771671; AID1771675; AID1771676; AID1771700; AID1772744; AID1772745; AID1807691; AID1807692; AID1815232; AID1815787; AID1815789; AID1824039; AID1824040; AID1824041; AID1848536; AID1848537; AID1853203; AID1865379; AID1865380; AID1865381; AID1865382; AID1867479; AID1880129; AID1880130; AID1882660; AID1882661; AID1884789; AID1884790; AID1884791; AID1896772; AID1896773; AID1896774; AID1896775; AID1898661; AID1898662; AID1898665; AID1898674; AID1904310; AID1904311; AID1909240; AID1909241; AID1909242; AID1909243; AID1915575; AID1915576
Epidermal growth factor receptor	Homo sapiens (human)	Ki	0.0666	0.0000	0.2953	3.5000	AID1274037; AID1274046; AID1274049; AID1441937; AID1441938; AID1441939; AID1445479; AID1445480; AID1445481; AID1865634; AID1865637
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50 (µMol)	2.8561	0.0001	0.5453	10.0000	AID1167102; AID1289550; AID1289551; AID1289555; AID1291334; AID1676531
Insulin receptor	Homo sapiens (human)	GI50	0.5000	0.1900	0.5450	1.2000	AID1481348
Insulin receptor	Homo sapiens (human)	IC50 (µMol)	0.9120	0.0017	0.8479	10.0000	AID1167161
Insulin-like growth factor 1 receptor	Homo sapiens (human)	GI50	0.5600	0.1900	0.6025	1.3000	AID1481349
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50 (µMol)	2,900.0000	0.0003	0.4308	8.0000	AID1167110
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0004	0.3722	10.0000	AID1884793
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50 (µMol)	3.2600	0.0002	2.4585	9.9600	AID1804171
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	IC50 (µMol)	2.8557	0.0001	0.0780	1.0240	AID1167102; AID1289550; AID1289551; AID1289555; AID1291334; AID1391282
von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)	IC50 (µMol)	0.0020	0.0010	0.5240	0.8820	AID1904310; AID1904311
Dipeptidyl peptidase 1	Homo sapiens (human)	IC50 (µMol)	32.9000	0.0347	3.1515	10.0000	AID1599557
Histone deacetylase 4	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0006	1.0526	10.0000	AID1720096
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.0395	0.0005	1.3313	8.0000	AID1289550; AID1289551
Epidermal growth factor receptor	Mus musculus (house mouse)	GI50	2.6000	2.6000	2.6000	2.6000	AID1740135
Epidermal growth factor receptor	Mus musculus (house mouse)	IC50 (µMol)	0.0810	0.0810	0.0905	0.1000	AID1527521
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50 (µMol)	8.3850	0.0009	1.9014	10.0000	AID1167109; AID1484475
Histone deacetylase 1	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0001	0.5543	9.9000	AID1720096
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	IC50 (µMol)	3.4264	0.0001	0.1736	2.5900	AID1167102; AID1289550; AID1289551; AID1289555; AID1291334
Histone deacetylase 7	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0007	1.0260	9.9000	AID1720096
Histone deacetylase 2	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0001	0.7221	9.9700	AID1720096
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0005	0.7245	9.9000	AID1720096
Histone deacetylase 11	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0003	0.9298	9.9000	AID1720096
Histone deacetylase 8	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0007	0.9947	9.9000	AID1720096
Histone deacetylase 6	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0000	0.5376	9.9000	AID1720096
Histone deacetylase 9	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0005	0.9413	9.9000	AID1720096
ALK tyrosine kinase receptor	Homo sapiens (human)	IC50 (µMol)	0.1770	0.0001	0.3107	10.0000	AID1583835
Histone deacetylase 5	Homo sapiens (human)	IC50 (µMol)	1.0000	0.0007	0.9610	10.0000	AID1720096
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	30.0000	0.0009	1.1413	3.7000	AID1424922
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	0.2040	0.2040	0.2040	AID1425109
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	30.0000	0.0008	1.5144	9.0000	AID1425121
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	0.4350	0.4350	0.4350	AID1424975
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	0.2860	5.0765	16.4040	AID1425106
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	30.0000	0.0330	3.0646	48.8760	AID1424954
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	30.0000	0.0028	1.4744	8.7000	AID1424953
Aurora kinase A	Homo sapiens (human)	Kd	30.0000	0.0001	0.7342	9.3000	AID1424917
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	30.0000	0.0003	0.9086	28.6510	AID1425009
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	30.0000	0.0000	1.0768	9.0000	AID1424995
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	0.0260	1.3140	2.6020	AID1424896
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	30.0000	0.0020	1.6212	11.4330	AID1425155
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	0.0940	1.3910	3.5070	AID1424926
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.0170	0.3610	0.7050	AID1425097
Putative nucleoside diphosphate kinase	Homo sapiens (human)	Kd	30.0000	0.8620	0.8620	0.8620	AID1425092
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	0.2320	0.2320	0.2320	AID1424986
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	30.0000	0.0002	2.7105	56.0660	AID1425158
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	30.0000	0.0008	1.8410	23.2730	AID1425208
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	30.0000	0.0057	2.0095	12.2010	AID1424997
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	30.0000	0.0170	1.9737	29.9570	AID1425162
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1.3820	1.3820	1.3820	AID1425174
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	30.0000	0.0120	1.6396	7.2000	AID1425161
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	30.0000	0.0017	1.2483	9.9690	AID1425179
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	30.0000	0.0017	1.4788	7.3000	AID1424951
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	30.0000	0.0000	2.9234	57.4530	AID1425177
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	30.0000	0.0089	2.2738	23.3410	AID1425137
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	0.2090	0.6575	1.1060	AID1425173
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	30.0000	0.1700	1.5781	8.0000	AID1425050
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	30.0000	0.0082	2.3645	62.7720	AID1425054
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	30.0000	0.0140	1.8393	10.7330	AID1425033
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	30.0000	0.0027	2.5694	30.3710	AID1425100
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	30.0000	0.0000	1.0411	13.4530	AID1424890
Epidermal growth factor receptor	Homo sapiens (human)	EC50 (µMol)	1.1610	0.0020	0.9902	7.9300	AID1441913; AID1441914; AID1481350; AID1481351; AID1583839; AID1583840; AID1583841; AID1583844; AID1583845; AID1583851; AID1583855; AID1583862; AID1583870; AID1807693; AID1807694; AID1807698; AID1807699; AID1807700; AID1880122; AID1880123
Epidermal growth factor receptor	Homo sapiens (human)	Kd	0.1550	0.0001	1.3514	20.8270	AID1424983
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	EC50 (µMol)	0.1220	0.0020	0.1293	0.6900	AID1880133
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	30.0000	0.0020	1.3484	9.2000	AID1425094
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	0.1840	0.1840	0.1840	AID1425011
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	0.4510	0.4510	0.4510	AID1425169
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	0.0013	2.7081	26.3240	AID1425130
Insulin receptor	Homo sapiens (human)	Kd	30.0000	0.0017	1.0823	7.9060	AID1425026
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	30.0000	0.0002	1.1174	24.2210	AID1425034
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	30.0000	0.0008	1.4238	8.4000	AID1425008
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	0.2880	1.4952	3.0490	AID1424937
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	2.1210	2.1210	2.1210	AID1425146
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	30.0000	0.0048	1.0986	7.4000	AID1425003
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	0.0290	0.0290	0.0290	AID1424914
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	30.0000	0.0003	1.3708	17.1520	AID1425212
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	30.0000	0.0006	1.0485	5.7000	AID1425037
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	30.0000	0.0007	0.8642	27.5420	AID1425154
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	30.0000	0.0010	1.9211	19.2170	AID1425022
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	0.0080	0.0080	0.0080	AID1425176
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.2020	0.2020	0.2020	AID1424969
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	30.0000	0.0003	2.0343	15.9930	AID1425017
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	30.0000	0.0001	1.0050	11.1070	AID1425104
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	0.0470	9.6832	33.6550	AID1424915
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	3.5690	3.5690	3.5690	AID1425145
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	0.0030	1.2196	17.3640	AID1424919
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	30.0000	0.0010	1.1393	19.3160	AID1425111
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	30.0000	0.0003	1.5581	6.2000	AID1425004
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	0.0640	0.2750	0.4860	AID1425202
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	30.0000	0.0033	1.6050	8.6000	AID1424946
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	0.0060	0.2505	0.4950	AID1425170
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	30.0000	0.0002	1.5077	9.6000	AID1425175
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	0.0520	1.7535	3.4550	AID1425128
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	30.0000	0.0002	1.6258	26.0180	AID1424924
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	30.0000	0.0001	2.0569	9.5000	AID1425110
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	3.6580	0.0040	6.7556	88.9030	AID1425093
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	30.0000	0.0014	1.3604	8.8000	AID1425002
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	0.0003	1.7922	21.3520	AID1425129
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	30.0000	0.0039	2.9479	23.2450	AID1425123
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	0.0020	1.6906	12.0220	AID1424996
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	30.0000	0.0010	2.5309	28.8720	AID1424968
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	0.0330	0.0330	0.0330	AID1425150
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	30.0000	0.0041	1.8000	9.8000	AID1424987
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	5.4810	5.4810	5.4810	AID1425098
Nucleoside diphosphate kinase B	Homo sapiens (human)	Kd	30.0000	0.1420	0.1420	0.1420	AID1425091
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	0.0020	8.5577	49.2780	AID1425125
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	30.0000	0.0130	0.7408	4.1000	AID1425124
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.2430	6.4343	67.9140	AID1425001
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	30.0000	0.0013	1.1805	4.8000	AID1425164
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	30.0000	0.0016	1.2166	7.8000	AID1425030
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	30.0000	0.0070	1.5179	10.4870	AID1424944
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	0.1700	5.5791	22.4940	AID1424908
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	4.1030	4.1030	4.1030	AID1424977
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	0.4300	5.2743	9.8000	AID1425061
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	30.0000	0.0030	3.9689	58.2400	AID1425069
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	0.0120	1.0875	2.1630	AID1424970
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	30.0000	0.0001	2.7441	7.3000	AID1425056
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	30.0000	0.0009	1.0752	8.1980	AID1424988
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	30.0000	0.0004	3.1536	53.1980	AID1424992
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	30.0000	0.0009	1.5575	8.7000	AID1425207
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	0.0030	0.0045	0.0060	AID1424959
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	0.0030	0.0030	0.0030	AID1425107
Wee1-like protein kinase	Homo sapiens (human)	Kd	30.0000	0.0014	3.5389	65.1580	AID1425210
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	0.1190	0.1190	0.1190	AID1425018
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	0.9620	0.9620	0.9620	AID1424980
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	0.0006	1.0621	4.4000	AID1424910
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	0.0021	1.6196	8.7000	AID1424911
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	0.6290	0.6290	0.6290	AID1425072
Myosin-10	Homo sapiens (human)	Kd	30.0000	0.2290	0.4935	0.7580	AID1425079
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	30.0000	0.0039	1.6429	9.6000	AID1425039
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	30.0000	0.0002	0.9559	9.9000	AID1425006
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	30.0000	0.0600	1.5010	7.0000	AID1424921
Activin receptor type-1B	Homo sapiens (human)	Kd	30.0000	0.0040	1.5110	15.2580	AID1424901
TGF-beta receptor type-1	Homo sapiens (human)	Kd	30.0000	0.0050	2.2785	9.6000	AID1425196
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	0.0120	0.0120	0.0120	AID1424999
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	30.0000	0.0010	3.4578	39.5530	AID1424960
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	0.0400	0.0400	0.0400	AID1425010
Protein kinase C iota type	Homo sapiens (human)	Kd	30.0000	0.0260	9.3316	51.0180	AID1425133
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	2.6070	2.6070	2.6070	AID1425168
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	0.3210	0.0010	1.0095	8.7000	AID1425193
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	30.0000	0.0002	1.1249	14.9240	AID1424891
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	30.0000	0.0003	1.2424	10.8370	AID1425007
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1.1890	1.4020	1.6150	AID1425012
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	30.0000	0.0070	2.0052	9.2260	AID1425188
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	0.0050	0.0050	0.0050	AID1425141
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	30.0000	0.0110	2.0965	26.0590	AID1425063
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	30.0000	0.0020	1.4596	8.1000	AID1425064
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	30.0000	0.0050	2.0462	6.6000	AID1425040
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	0.2080	3.6125	7.0170	AID1425113
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	30.0000	0.0010	2.5756	19.3520	AID1424961
Casein kinase I isoform delta	Homo sapiens (human)	Kd	30.0000	0.0150	2.2270	18.3960	AID1424962
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	30.0000	0.0003	2.0274	14.7420	AID1425065
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.4640	0.4640	0.4640	AID1425206
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	0.0120	0.0120	0.3320	0.6520	AID1424932
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	30.0000	0.0130	1.4086	12.4090	AID1424963
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1.6890	1.6890	1.6890	AID1424894
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	30.0000	0.0020	1.8791	29.8810	AID1424955
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	30.0000	0.0070	1.1384	6.5000	AID1424956
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	30.0000	0.0100	2.4499	9.0000	AID1424957
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	30.0000	0.0060	2.4754	22.5430	AID1425013
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	30.0000	0.0070	1.0057	6.1680	AID1425014
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	30.0000	0.0025	1.6783	7.7000	AID1424949
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	30.0000	0.0010	1.6166	9.9010	AID1424950
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	4.4930	4.4930	4.4930	AID1425149
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	30.0000	0.0061	1.5252	8.5000	AID1425027
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	30.0000	0.0170	2.8896	37.6050	AID1425160
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	30.0000	0.1100	1.5649	6.5000	AID1425086
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	30.0000	0.1700	5.9368	38.0880	AID1425087
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	30.0000	0.0034	2.3943	6.5000	AID1425043
LIM domain kinase 1	Homo sapiens (human)	Kd	30.0000	0.0260	1.7840	21.0890	AID1425035
LIM domain kinase 2	Homo sapiens (human)	Kd	30.0000	0.0570	4.9717	52.0560	AID1425036
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	30.0000	0.0010	1.6354	5.9000	AID1425057
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	3.3160	3.3160	3.3160	AID1425211
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	0.0060	1.4681	10.2120	AID1425126
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	30.0000	0.0069	2.1713	6.4100	AID1424993
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	30.0000	0.0002	1.2100	5.9000	AID1424990
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	30.0000	0.0003	2.1678	26.3990	AID1424994
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	30.0000	0.0012	3.1525	43.9420	AID1424989
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1.0360	1.0360	1.0360	AID1424909
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	0.0130	1.8368	3.4930	AID1424907
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1.3480	1.3480	1.3480	AID1425148
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	0.0360	2.7735	5.5110	AID1424899
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	0.0040	0.0040	0.0040	AID1424898
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	0.7590	0.7590	0.7590	AID1425153
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	30.0000	0.0460	1.4506	6.6000	AID1424965
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	30.0000	0.0080	3.0602	63.6140	AID1424945
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	0.0320	1.2007	3.3560	AID1424948
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	30.0000	0.0430	1.3757	8.3000	AID1424947
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	30.0000	0.0011	1.5855	10.0000	AID1424941
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	30.0000	0.0010	0.8233	5.6000	AID1424942
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	0.9830	0.9830	0.9830	AID1425108
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	30.0000	0.0002	1.1386	8.7730	AID1425038
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	0.1480	1.2270	2.5970	AID1425203
Protein kinase C theta type	Homo sapiens (human)	Kd	30.0000	0.0007	1.6140	7.2000	AID1425134
Activin receptor type-1	Homo sapiens (human)	Kd	30.0000	0.0040	1.4853	16.1210	AID1424900
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	30.0000	0.0030	2.0718	8.4000	AID1425078
Focal adhesion kinase 1	Homo sapiens (human)	Kd	30.0000	0.0005	1.2255	13.0390	AID1425142
Protein kinase C delta type	Homo sapiens (human)	Kd	30.0000	0.0002	1.1261	9.2060	AID1425131
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	0.5250	0.0006	1.5299	10.1530	AID1424925
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	30.0000	0.0020	1.7138	9.6000	AID1425201
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	30.0000	0.0002	1.6314	71.4840	AID1424972
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	0.0031	1.4681	14.0430	AID1425052
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	30.0000	0.0002	1.7120	25.9020	AID1425185
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	30.0000	0.0037	1.8913	15.3890	AID1425122
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	30.0000	0.0002	2.6590	65.6770	AID1425042
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	30.0000	0.0420	2.0073	9.9000	AID1425062
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	30.0000	0.0031	2.3045	6.0000	AID1425099
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	0.0002	1.8602	17.5260	AID1425182
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	30.0000	0.0970	2.5995	12.4730	AID1425044
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	0.0200	0.4603	1.3290	AID1425024
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	30.0000	0.0003	1.7555	13.4620	AID1425157
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	30.0000	0.0018	1.0064	11.2690	AID1425200
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	30.0000	0.0005	1.0209	7.8000	AID1424929
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	30.0000	0.0003	1.5044	20.3010	AID1424928
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	30.0000	0.0001	2.1016	40.2910	AID1424981
Activin receptor type-2B	Homo sapiens (human)	Kd	30.0000	0.0076	2.7328	9.9000	AID1424902
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	30.0000	0.0190	2.5917	14.3770	AID1424923
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	30.0000	0.0043	1.7430	9.0000	AID1425144
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	30.0000	0.0016	0.7072	3.8000	AID1425138
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	30.0000	0.0009	1.2571	4.5180	AID1424940
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	30.0000	0.0051	1.1093	8.3000	AID1425023
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	30.0000	0.0011	1.9450	30.4140	AID1425143
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	30.0000	0.0049	2.2835	29.9330	AID1425074
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	0.3650	0.3650	0.3650	AID1425172
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	0.0030	0.0030	0.0030	AID1424952
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	0.0140	0.1425	0.2710	AID1424895
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	30.0000	0.0560	1.5651	9.4000	AID1425183
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	30.0000	0.0025	1.4445	6.5000	AID1424991
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	0.4320	0.4320	0.4320	AID1424978
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	30.0000	0.0280	2.5286	22.7260	AID1425159
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	30.0000	0.0030	1.2088	7.9000	AID1425081
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	30.0000	0.0001	0.4610	3.7430	AID1425058
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	30.0000	0.0030	0.9949	5.9000	AID1425178
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	30.0000	0.0013	3.1729	49.8130	AID1425117
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	30.0000	0.0018	1.7527	9.9000	AID1425118
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	30.0000	0.0000	0.5036	8.5000	AID1425059
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	30.0000	0.0300	1.9215	5.4600	AID1424930
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	30.0000	0.0110	1.5639	17.9840	AID1425045
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	0.0020	0.0170	0.0260	AID1425066
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	30.0000	0.0030	1.9888	42.2800	AID1424973
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	30.0000	0.0012	1.3707	13.7110	AID1424889
Myosin light chain kinase 3	Homo sapiens (human)	Kd	30.0000	0.0020	1.6184	10.4240	AID1425082
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	2.5660	2.5660	2.5660	AID1425019
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	30.0000	0.0570	4.5547	14.0200	AID1424933
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	30.0000	0.0370	1.9625	9.5000	AID1424935
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	0.0780	1.6997	3.9570	AID1424892
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	0.0990	0.7365	1.3740	AID1425119
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	30.0000	0.0012	1.3350	9.9000	AID1425209
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	0.0030	1.2292	9.3110	AID1425147
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	0.1160	0.7604	1.5000	AID1424998
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	30.0000	0.0001	1.8425	11.1030	AID1425068
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	0.0060	0.0060	0.0060	AID1424979
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	30.0000	0.0004	2.1612	18.7570	AID1425189
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	0.3160	1.7208	3.6720	AID1425186
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	0.0230	3.1137	22.7470	AID1424904
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	30.0000	0.0051	1.6413	15.4350	AID1425053
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	30.0000	0.0080	1.1241	3.1180	AID1425067
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	0.0030	0.0030	0.0030	AID1425015
Misshapen-like kinase 1	Homo sapiens (human)	Kd	30.0000	0.0010	1.1425	8.9000	AID1425077
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.0940	5.1673	65.3020	AID1424905
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	2.9730	0.0030	2.7522	8.8000	AID1425115
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	30.0000	0.0049	0.6880	4.5000	AID1425060
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	30.0000	0.0160	2.7428	19.6170	AID1425089
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	30.0000	0.0030	3.6719	8.7000	AID1425088
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	0.0860	0.0860	0.0860	AID1424974
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	30.0000	0.0010	0.9378	5.5000	AID1425051
Aurora kinase B	Homo sapiens (human)	Kd	30.0000	0.0020	1.0614	22.8520	AID1424918
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	30.0000	0.0054	1.1029	4.9000	AID1425070
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	30.0000	0.0010	1.9148	6.8000	AID1424927
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	30.0000	0.1700	2.4294	8.3000	AID1425085
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	30.0000	0.0000	3.2331	52.8470	AID1424931
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	0.3110	1.9519	3.8400	AID1425204
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	0.0020	0.0020	0.0020	AID1425195
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	30.0000	0.0440	0.9285	2.9000	AID1425116
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	30.0000	0.0700	6.5647	50.5360	AID1425049
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	30.0000	0.0060	1.5331	9.9000	AID1425047
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	30.0000	0.0580	1.9224	4.8360	AID1424984
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	0.0090	4.1035	8.1980	AID1425016
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	30.0000	0.0081	2.3723	25.0190	AID1425136
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	30.0000	0.0001	0.6774	4.6000	AID1425095
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1.2400	1.2400	1.2400	AID1425083
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	30.0000	0.0011	1.8165	41.7950	AID1425166
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	0.0000	3.8573	99.2320	AID1425171
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	30.0000	0.0002	2.7131	14.1960	AID1425191
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	0.5730	1.7403	3.0540	AID1424971
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	30.0000	0.0020	1.4122	8.3000	AID1424958
Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)	EC50 (µMol)	1.7480	0.0260	2.5324	6.2580	AID1583842
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	30.0000	0.0530	2.0622	5.7000	AID1424964
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	0.0030	0.0045	0.0060	AID1425000
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.0110	0.0110	0.0110	AID1425020
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	30.0000	0.0022	2.4097	56.0320	AID1424920
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	0.0030	0.0050	0.0070	AID1425096
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	30.0000	0.0017	3.4719	34.1450	AID1425029
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	30.0000	0.0023	1.7034	13.6380	AID1425213
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	0.0320	1.8032	5.6350	AID1424939
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	3.9200	3.9200	3.9200	AID1425084
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	30.0000	0.0074	1.7380	8.3000	AID1425181
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	0.0070	0.0070	0.0070	AID1425187
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	30.0000	0.0060	1.0226	4.4000	AID1425090
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	0.0050	1.1581	9.1280	AID1425127
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	30.0000	0.0009	1.7674	49.6010	AID1425192
Septin-9	Homo sapiens (human)	Kd	30.0000	0.0100	0.2430	0.6350	AID1425165
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	30.0000	0.0040	2.4153	23.7620	AID1425163
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	30.0000	0.0047	1.3935	10.0000	AID1425199
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	30.0000	0.0100	2.0176	12.9420	AID1425190
ALK tyrosine kinase receptor	Homo sapiens (human)	EC50 (µMol)	1.7480	0.0005	1.9984	6.2580	AID1583842
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	30.0000	0.0007	1.4717	9.3000	AID1425021
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	0.0025	1.7646	6.2000	AID1424912
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	30.0000	0.0005	1.5086	10.3180	AID1425167
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	30.0000	0.0024	1.3298	6.9000	AID1425046
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	2.7460	2.7460	2.7460	AID1425198
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	30.0000	0.0005	1.9494	50.2140	AID1425055
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	0.0110	1.4797	6.7000	AID1425156
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	30.0000	0.0340	3.6252	50.0050	AID1424934
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	30.0000	0.0070	1.7137	25.5810	AID1425028
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	30.0000	0.0970	2.3978	8.7000	AID1424966
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	30.0000	0.0390	2.3970	8.4000	AID1425048
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Epidermal growth factor receptor	Homo sapiens (human)	DC50	2.0000	0.0117	0.0139	0.0223	AID1691144; AID1691145
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2531)

Process	via Protein(s)	Taxonomy
positive regulation of gene expression	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
cartilage condensation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
ovarian cumulus expansion	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
osteoblast differentiation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
eye development	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
chondrocyte development	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
inflammatory response	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
central nervous system neuron differentiation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
proteoglycan biosynthetic process	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of bone mineralization	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
BMP signaling pathway	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
retinal ganglion cell axon guidance	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of chondrocyte differentiation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
ovulation cycle	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of osteoblast differentiation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
retina development in camera-type eye	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
endochondral bone morphogenesis	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of cartilage development	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
cellular response to BMP stimulus	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
negative regulation of chondrocyte proliferation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
dorsal/ventral pattern formation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
protein phosphorylation	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
cellular response to growth factor stimulus	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
heme biosynthetic process	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
positive regulation of lipoprotein transport	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
positive regulation of centriole replication	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
centriole replication	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
positive regulation of centriole replication	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
cilium assembly	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
trophoblast giant cell differentiation	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
translational initiation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
chromosome segregation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
response to virus	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
RNA secondary structure unwinding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of gene expression	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
Wnt signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of translation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of cell growth	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of cell growth	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of protein-containing complex assembly	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of protein autophosphorylation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of type I interferon production	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
DNA duplex unwinding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of interferon-alpha production	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of interferon-beta production	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
stress granule assembly	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of toll-like receptor 7 signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of toll-like receptor 8 signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
intracellular signal transduction	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of translation in response to endoplasmic reticulum stress	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytosolic ribosome assembly	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of apoptotic process	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of apoptotic process	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of viral genome replication	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
innate immune response	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of translation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of translational initiation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
lipid homeostasis	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cellular response to arsenic-containing substance	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cellular response to osmotic stress	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of chemokine (C-C motif) ligand 5 production	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of protein serine/threonine kinase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
intrinsic apoptotic signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cellular response to virus	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of non-canonical NF-kappaB signal transduction	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of protein acetylation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
positive regulation of protein K63-linked ubiquitination	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
protein localization to cytoplasmic stress granule	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
negative regulation of gene expression	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
gamete generation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cell differentiation	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
pyridoxal 5'-phosphate salvage	Pyridoxal kinase	Homo sapiens (human)
pyridoxal metabolic process	Pyridoxal kinase	Homo sapiens (human)
pyridoxamine metabolic process	Pyridoxal kinase	Homo sapiens (human)
mitotic cell cycle	Citron Rho-interacting kinase	Homo sapiens (human)
mitotic cytokinesis	Citron Rho-interacting kinase	Homo sapiens (human)
positive regulation of cytokinesis	Citron Rho-interacting kinase	Homo sapiens (human)
negative regulation of hippo signaling	Citron Rho-interacting kinase	Homo sapiens (human)
generation of neurons	Citron Rho-interacting kinase	Homo sapiens (human)
neuron apoptotic process	Citron Rho-interacting kinase	Homo sapiens (human)
DNA damage checkpoint signaling	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
inner cell mass cell proliferation	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
DNA replication	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
DNA repair	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
chromatin remodeling	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
nucleus organization	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
mitotic G2 DNA damage checkpoint signaling	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
regulation of double-strand break repair via homologous recombination	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
regulation of cell population proliferation	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
signal transduction in response to DNA damage	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
mitotic G2/M transition checkpoint	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
positive regulation of cell cycle	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
negative regulation of mitotic nuclear division	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
regulation of mitotic centrosome separation	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
negative regulation of G0 to G1 transition	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
cellular response to mechanical stimulus	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
cellular response to caffeine	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
replicative senescence	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
apoptotic process involved in development	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
negative regulation of DNA biosynthetic process	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein phosphorylation	Aurora kinase A	Homo sapiens (human)
response to wounding	Aurora kinase A	Homo sapiens (human)
liver regeneration	Aurora kinase A	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Aurora kinase A	Homo sapiens (human)
mitotic cell cycle	Aurora kinase A	Homo sapiens (human)
chromatin remodeling	Aurora kinase A	Homo sapiens (human)
protein phosphorylation	Aurora kinase A	Homo sapiens (human)
apoptotic process	Aurora kinase A	Homo sapiens (human)
spindle organization	Aurora kinase A	Homo sapiens (human)
spindle assembly involved in female meiosis I	Aurora kinase A	Homo sapiens (human)
mitotic centrosome separation	Aurora kinase A	Homo sapiens (human)
anterior/posterior axis specification	Aurora kinase A	Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycle	Aurora kinase A	Homo sapiens (human)
negative regulation of gene expression	Aurora kinase A	Homo sapiens (human)
peptidyl-serine phosphorylation	Aurora kinase A	Homo sapiens (human)
regulation of protein stability	Aurora kinase A	Homo sapiens (human)
negative regulation of protein binding	Aurora kinase A	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Aurora kinase A	Homo sapiens (human)
negative regulation of apoptotic process	Aurora kinase A	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Aurora kinase A	Homo sapiens (human)
positive regulation of mitotic nuclear division	Aurora kinase A	Homo sapiens (human)
positive regulation of mitotic cell cycle	Aurora kinase A	Homo sapiens (human)
regulation of centrosome cycle	Aurora kinase A	Homo sapiens (human)
protein autophosphorylation	Aurora kinase A	Homo sapiens (human)
cell division	Aurora kinase A	Homo sapiens (human)
centrosome localization	Aurora kinase A	Homo sapiens (human)
cilium disassembly	Aurora kinase A	Homo sapiens (human)
protein localization to centrosome	Aurora kinase A	Homo sapiens (human)
positive regulation of mitochondrial fission	Aurora kinase A	Homo sapiens (human)
positive regulation of oocyte maturation	Aurora kinase A	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Aurora kinase A	Homo sapiens (human)
neuron projection extension	Aurora kinase A	Homo sapiens (human)
mitotic spindle organization	Aurora kinase A	Homo sapiens (human)
regulation of cytokinesis	Aurora kinase A	Homo sapiens (human)
receptor-mediated endocytosis	Cyclin-G-associated kinase	Homo sapiens (human)
endoplasmic reticulum organization	Cyclin-G-associated kinase	Homo sapiens (human)
Golgi organization	Cyclin-G-associated kinase	Homo sapiens (human)
negative regulation of neuron projection development	Cyclin-G-associated kinase	Homo sapiens (human)
synaptic vesicle uncoating	Cyclin-G-associated kinase	Homo sapiens (human)
protein localization to Golgi apparatus	Cyclin-G-associated kinase	Homo sapiens (human)
intracellular transport	Cyclin-G-associated kinase	Homo sapiens (human)
clathrin coat assembly	Cyclin-G-associated kinase	Homo sapiens (human)
chaperone cofactor-dependent protein refolding	Cyclin-G-associated kinase	Homo sapiens (human)
clathrin coat disassembly	Cyclin-G-associated kinase	Homo sapiens (human)
clathrin-dependent endocytosis	Cyclin-G-associated kinase	Homo sapiens (human)
protein localization to plasma membrane	Cyclin-G-associated kinase	Homo sapiens (human)
Golgi to lysosome transport	Cyclin-G-associated kinase	Homo sapiens (human)
regulation of clathrin coat assembly	Cyclin-G-associated kinase	Homo sapiens (human)
protein phosphorylation	Ephrin type-B receptor 6	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-B receptor 6	Homo sapiens (human)
axon guidance	Ephrin type-B receptor 6	Homo sapiens (human)
fatty acid beta-oxidation using acyl-CoA oxidase	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
lipid homeostasis	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
negative regulation of myotube differentiation	Histone deacetylase 3	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 3	Homo sapiens (human)
establishment of mitotic spindle orientation	Histone deacetylase 3	Homo sapiens (human)
in utero embryonic development	Histone deacetylase 3	Homo sapiens (human)
positive regulation of protein phosphorylation	Histone deacetylase 3	Homo sapiens (human)
chromatin organization	Histone deacetylase 3	Homo sapiens (human)
transcription by RNA polymerase II	Histone deacetylase 3	Homo sapiens (human)
protein deacetylation	Histone deacetylase 3	Homo sapiens (human)
regulation of mitotic cell cycle	Histone deacetylase 3	Homo sapiens (human)
positive regulation of protein ubiquitination	Histone deacetylase 3	Homo sapiens (human)
regulation of protein stability	Histone deacetylase 3	Homo sapiens (human)
positive regulation of TOR signaling	Histone deacetylase 3	Homo sapiens (human)
circadian regulation of gene expression	Histone deacetylase 3	Homo sapiens (human)
regulation of multicellular organism growth	Histone deacetylase 3	Homo sapiens (human)
positive regulation of protein import into nucleus	Histone deacetylase 3	Homo sapiens (human)
regulation of circadian rhythm	Histone deacetylase 3	Homo sapiens (human)
negative regulation of apoptotic process	Histone deacetylase 3	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Histone deacetylase 3	Homo sapiens (human)
negative regulation of JNK cascade	Histone deacetylase 3	Homo sapiens (human)
spindle assembly	Histone deacetylase 3	Homo sapiens (human)
establishment of skin barrier	Histone deacetylase 3	Homo sapiens (human)
cellular response to fluid shear stress	Histone deacetylase 3	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Histone deacetylase 3	Homo sapiens (human)
DNA repair-dependent chromatin remodeling	Histone deacetylase 3	Homo sapiens (human)
cornified envelope assembly	Histone deacetylase 3	Homo sapiens (human)
negative regulation of cardiac muscle cell differentiation	Histone deacetylase 3	Homo sapiens (human)
epigenetic regulation of gene expression	Histone deacetylase 3	Homo sapiens (human)
toll-like receptor 2 signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of cytokine-mediated signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
adaptive immune response	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of T-helper 1 type immune response	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
apoptotic process	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
inflammatory response	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
signal transduction	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
canonical NF-kappaB signal transduction	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
JNK cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cytokine-mediated signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of protein ubiquitination	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of protein binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of chemokine production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interferon-alpha production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interferon-beta production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of type II interferon production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interleukin-12 production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interleukin-2 production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of interleukin-6 production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of stress-activated MAPK cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
immature T cell proliferation in thymus	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of immature T cell proliferation in thymus	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
CD4-positive, alpha-beta T cell proliferation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
defense response to bacterium	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of apoptotic process	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
response to exogenous dsRNA	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
innate immune response	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of T-helper 1 cell differentiation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of JNK cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
defense response to Gram-positive bacterium	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
T cell receptor signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein homooligomerization	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
stress-activated MAPK cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of macrophage cytokine production	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
ERK1 and ERK2 cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 1 signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathway	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
response to interleukin-1	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
response to interleukin-12	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
response to interleukin-18	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cellular response to lipoteichoic acid	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cellular response to peptidoglycan	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cellular response to muramyl dipeptide	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
activation of cysteine-type endopeptidase activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
xenophagy	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of protein K63-linked ubiquitination	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of xenophagy	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of CD4-positive, alpha-beta T cell proliferation	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
chromatin remodeling	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
apoptotic process	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
chromosome segregation	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
regulation of sister chromatid cohesion	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
mitotic spindle assembly checkpoint signaling	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
cell division	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
regulation of chromosome segregation	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
meiotic sister chromatid cohesion, centromeric	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
mitochondrion organization	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial genome maintenance	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial fission	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
neural tube closure	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
apoptotic process	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrion organization	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
inner mitochondrial membrane organization	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
visual perception	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial fusion	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
axonal transport of mitochondrion	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
positive regulation of interleukin-17 production	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
cristae formation	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
negative regulation of apoptotic process	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
GTP metabolic process	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
protein complex oligomerization	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
membrane fusion	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
cellular senescence	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
membrane tubulation	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane fusion	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
positive regulation of T-helper 17 cell lineage commitment	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
regulation of double-strand break repair via homologous recombination	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of protein ubiquitination	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of protein localization	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to UV	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to gamma radiation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA repair-dependent chromatin remodeling	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neuroblast proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein demethylation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neuron projection development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cerebral cortex development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
neuron maturation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA damage response, signal transduction by p53 class mediator	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of cell size	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of DNA-templated transcription	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Lysine-specific histone demethylase 1A	Homo sapiens (human)
guanine metabolic process	Lysine-specific histone demethylase 1A	Homo sapiens (human)
muscle cell development	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of androgen receptor signaling pathway	Lysine-specific histone demethylase 1A	Homo sapiens (human)
response to fungicide	Lysine-specific histone demethylase 1A	Homo sapiens (human)
cellular response to cAMP	Lysine-specific histone demethylase 1A	Homo sapiens (human)
regulation of DNA methylation-dependent heterochromatin formation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Lysine-specific histone demethylase 1A	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of neural precursor cell proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
positive regulation of stem cell proliferation	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin remodeling	Lysine-specific histone demethylase 1A	Homo sapiens (human)
GTP biosynthetic process	Putative nucleoside diphosphate kinase	Homo sapiens (human)
UTP biosynthetic process	Putative nucleoside diphosphate kinase	Homo sapiens (human)
CTP biosynthetic process	Putative nucleoside diphosphate kinase	Homo sapiens (human)
regulation of apoptotic process	Putative nucleoside diphosphate kinase	Homo sapiens (human)
regulation of translational initiation	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
ribosome assembly	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
translational initiation	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
epithelial to mesenchymal transition	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of protein phosphorylation	Rho-associated protein kinase 2	Homo sapiens (human)
response to ischemia	Rho-associated protein kinase 2	Homo sapiens (human)
aortic valve morphogenesis	Rho-associated protein kinase 2	Homo sapiens (human)
protein phosphorylation	Rho-associated protein kinase 2	Homo sapiens (human)
smooth muscle contraction	Rho-associated protein kinase 2	Homo sapiens (human)
canonical NF-kappaB signal transduction	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of endothelial cell migration	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of cardiac muscle hypertrophy	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of gene expression	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of gene expression	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of centrosome duplication	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of angiogenesis	Rho-associated protein kinase 2	Homo sapiens (human)
actin cytoskeleton organization	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of cell adhesion	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of cell migration	Rho-associated protein kinase 2	Homo sapiens (human)
cortical actin cytoskeleton organization	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of nervous system process	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of connective tissue growth factor production	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of actin cytoskeleton organization	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of myosin-light-chain-phosphatase activity	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of circadian rhythm	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of MAPK cascade	Rho-associated protein kinase 2	Homo sapiens (human)
modulation by host of viral process	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of nitric oxide biosynthetic process	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of keratinocyte differentiation	Rho-associated protein kinase 2	Homo sapiens (human)
rhythmic process	Rho-associated protein kinase 2	Homo sapiens (human)
centrosome duplication	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of stress fiber assembly	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of stress fiber assembly	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of focal adhesion assembly	Rho-associated protein kinase 2	Homo sapiens (human)
mRNA destabilization	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of biomineral tissue development	Rho-associated protein kinase 2	Homo sapiens (human)
cellular response to testosterone stimulus	Rho-associated protein kinase 2	Homo sapiens (human)
response to transforming growth factor beta	Rho-associated protein kinase 2	Homo sapiens (human)
protein localization to plasma membrane	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of fibroblast growth factor production	Rho-associated protein kinase 2	Homo sapiens (human)
blood vessel diameter maintenance	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of angiotensin-activated signaling pathway	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of protein localization to lysosome	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of cellular response to hypoxia	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of amyloid-beta formation	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of protein localization to early endosome	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of amyloid precursor protein catabolic process	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of establishment of endothelial barrier	Rho-associated protein kinase 2	Homo sapiens (human)
negative regulation of bicellular tight junction assembly	Rho-associated protein kinase 2	Homo sapiens (human)
cellular response to acetylcholine	Rho-associated protein kinase 2	Homo sapiens (human)
positive regulation of connective tissue replacement	Rho-associated protein kinase 2	Homo sapiens (human)
response to angiotensin	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of establishment of cell polarity	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of cell motility	Rho-associated protein kinase 2	Homo sapiens (human)
actomyosin structure organization	Rho-associated protein kinase 2	Homo sapiens (human)
peptidyl-threonine phosphorylation	Rho-associated protein kinase 2	Homo sapiens (human)
mitotic cytokinesis	Rho-associated protein kinase 2	Homo sapiens (human)
embryonic morphogenesis	Rho-associated protein kinase 2	Homo sapiens (human)
regulation of cell junction assembly	Rho-associated protein kinase 2	Homo sapiens (human)
Rho protein signal transduction	Rho-associated protein kinase 2	Homo sapiens (human)
autophagosome assembly	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
autophagy	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein localization	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
negative regulation of cell population proliferation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
positive regulation of autophagy	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
regulation of tumor necrosis factor-mediated signaling pathway	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
macroautophagy	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
regulation of macroautophagy	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
neuron projection regeneration	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
neuron projection development	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
cellular response to nutrient levels	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
response to starvation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
regulation of protein lipidation	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
positive regulation of autophagosome assembly	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
axon extension	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
autophagy of mitochondrion	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
reticulophagy	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
piecemeal microautophagy of the nucleus	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
negative regulation of collateral sprouting	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
endothelial cell proliferation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
mRNA catabolic process	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
regulation of macroautophagy	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
positive regulation of RNA splicing	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
cellular response to unfolded protein	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
response to endoplasmic reticulum stress	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
peptidyl-serine autophosphorylation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
IRE1-mediated unfolded protein response	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
positive regulation of JUN kinase activity	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
mRNA splicing, via endonucleolytic cleavage and ligation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
cellular response to hydrogen peroxide	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
cellular response to glucose stimulus	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
positive regulation of endoplasmic reticulum unfolded protein response	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
insulin metabolic process	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
peptidyl-serine trans-autophosphorylation	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
negative regulation of cytokine production	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
chromatin remodeling	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
regulation of DNA-templated transcription	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
protein phosphorylation	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
inflammatory response	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
axon guidance	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
positive regulation of CREB transcription factor activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
intracellular signal transduction	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
post-translational protein modification	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
negative regulation of DNA-templated transcription	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
regulation of postsynapse organization	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
cis assembly of pre-catalytic spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
mRNA splicing, via spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
osteoblast differentiation	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
negative regulation of cytokine production	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
chromatin remodeling	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
regulation of DNA-templated transcription	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
protein phosphorylation	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
inflammatory response	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
positive regulation of CREB transcription factor activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
intracellular signal transduction	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
post-translational protein modification	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Serine/threonine-protein kinase 16	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase 16	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Serine/threonine-protein kinase 16	Homo sapiens (human)
neuron migration	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase-like 5	Homo sapiens (human)
positive regulation of GTPase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
positive regulation of axon extension	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein autophosphorylation	Cyclin-dependent kinase-like 5	Homo sapiens (human)
regulation of dendrite development	Cyclin-dependent kinase-like 5	Homo sapiens (human)
positive regulation of dendrite morphogenesis	Cyclin-dependent kinase-like 5	Homo sapiens (human)
modulation of chemical synaptic transmission	Cyclin-dependent kinase-like 5	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase-like 5	Homo sapiens (human)
positive regulation of dendritic spine development	Cyclin-dependent kinase-like 5	Homo sapiens (human)
regulation of postsynapse organization	Cyclin-dependent kinase-like 5	Homo sapiens (human)
regulation of cilium assembly	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 10	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase 10	Homo sapiens (human)
lymphocyte aggregation	Serine/threonine-protein kinase 10	Homo sapiens (human)
regulation of lymphocyte migration	Serine/threonine-protein kinase 10	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein kinase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D3	Homo sapiens (human)
sphingolipid biosynthetic process	Serine/threonine-protein kinase D3	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase D3	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D3	Homo sapiens (human)
mitotic chromosome condensation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
meiotic chromosome condensation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
meiotic chromosome segregation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
cell division	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
kinetochore organization	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
positive regulation of chromosome segregation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
positive regulation of chromosome separation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
positive regulation of chromosome condensation	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
signal transduction	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
cellular response to stress	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
microvillus assembly	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
negative regulation of cell-matrix adhesion	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of cell migration	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of ARF protein signal transduction	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of hippo signaling	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
negative regulation of apoptotic process	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of GTPase activity	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
regulation of JNK cascade	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of keratinocyte migration	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of focal adhesion assembly	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
positive regulation of focal adhesion disassembly	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
regulation of MAPK cascade	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
neuron projection morphogenesis	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
sister chromatid segregation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
inner cell mass cell fate commitment	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
inner cell mass cellular morphogenesis	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
hormone-mediated signaling pathway	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of transforming growth factor beta receptor signaling pathway	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
keratinocyte differentiation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of actin filament polymerization	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of intracellular estrogen receptor signaling pathway	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
hippo signaling	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of protein-containing complex assembly	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
negative regulation of cyclin-dependent protein serine/threonine kinase activity	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
cytoplasmic sequestering of protein	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
cell division	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
mammary gland epithelial cell differentiation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
negative regulation of protein localization to nucleus	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of ubiquitin-dependent protein catabolic process	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
positive regulation of apoptotic process	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of organ growth	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cytoskeleton organization	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cell migration	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
positive regulation of angiogenesis	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
dendritic spine development	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cellular response to organic cyclic compound	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cell-cell adhesion	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
regulation of MAPK cascade	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
response to oxidative stress	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of ubiquitin-protein transferase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of phospholipase C activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
mitotic cell cycle	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neural tube closure	Tyrosine-protein kinase ABL1	Homo sapiens (human)
B-1 B cell homeostasis	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of protein phosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
B cell proliferation involved in immune response	Tyrosine-protein kinase ABL1	Homo sapiens (human)
transitional one stage B cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
mismatch repair	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of DNA-templated transcription	Tyrosine-protein kinase ABL1	Homo sapiens (human)
autophagy	Tyrosine-protein kinase ABL1	Homo sapiens (human)
DNA damage response	Tyrosine-protein kinase ABL1	Homo sapiens (human)
integrin-mediated signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
canonical NF-kappaB signal transduction	Tyrosine-protein kinase ABL1	Homo sapiens (human)
associative learning	Tyrosine-protein kinase ABL1	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Tyrosine-protein kinase ABL1	Homo sapiens (human)
response to xenobiotic stimulus	Tyrosine-protein kinase ABL1	Homo sapiens (human)
post-embryonic development	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of autophagy	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of endothelial cell migration	Tyrosine-protein kinase ABL1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cerebellum morphogenesis	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of cell-cell adhesion	Tyrosine-protein kinase ABL1	Homo sapiens (human)
microspike assembly	Tyrosine-protein kinase ABL1	Homo sapiens (human)
actin cytoskeleton organization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
actin filament polymerization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of endocytosis	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of cell adhesion	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuron differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
BMP signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of BMP signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of axon extension	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of microtubule polymerization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of Cdc42 protein signal transduction	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of type II interferon production	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of interleukin-2 production	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of actin cytoskeleton organization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of osteoblast proliferation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular response to oxidative stress	Tyrosine-protein kinase ABL1	Homo sapiens (human)
response to endoplasmic reticulum stress	Tyrosine-protein kinase ABL1	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein modification process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuropilin signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
signal transduction in response to DNA damage	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of apoptotic process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of neuron apoptotic process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
endothelial cell migration	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of T cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of vasoconstriction	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of mitotic cell cycle	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of mitotic cell cycle	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Tyrosine-protein kinase ABL1	Homo sapiens (human)
alpha-beta T cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein autophosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of fibroblast proliferation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
spleen development	Tyrosine-protein kinase ABL1	Homo sapiens (human)
thymus development	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
activated T cell proliferation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuromuscular process controlling balance	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of release of sequestered calcium ion into cytosol	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of oxidoreductase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuron apoptotic process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of ubiquitin-protein transferase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
myoblast proliferation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of stress fiber assembly	Tyrosine-protein kinase ABL1	Homo sapiens (human)
establishment of localization in cell	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of cell cycle	Tyrosine-protein kinase ABL1	Homo sapiens (human)
mitochondrial depolarization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of focal adhesion assembly	Tyrosine-protein kinase ABL1	Homo sapiens (human)
Bergmann glial cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cardiac muscle cell proliferation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuroepithelial cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular response to hydrogen peroxide	Tyrosine-protein kinase ABL1	Homo sapiens (human)
ERK1 and ERK2 cascade	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase ABL1	Homo sapiens (human)
DNA conformation change	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular response to lipopolysaccharide	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Tyrosine-protein kinase ABL1	Homo sapiens (human)
response to epinephrine	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of protein serine/threonine kinase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular senescence	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cell-cell adhesion	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of dendrite development	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreading	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of hematopoietic stem cell differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of extracellular matrix organization	Tyrosine-protein kinase ABL1	Homo sapiens (human)
podocyte apoptotic process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cellular response to dopamine	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of establishment of T cell polarity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
DN4 thymocyte differentiation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein localization to cytoplasmic microtubule plus-end	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of microtubule binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of actin filament binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of modification of synaptic structure	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of blood vessel branching	Tyrosine-protein kinase ABL1	Homo sapiens (human)
activation of protein kinase C activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of double-strand break repair via homologous recombination	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of Wnt signaling pathway, planar cell polarity pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
regulation of cell motility	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Tyrosine-protein kinase ABL1	Homo sapiens (human)
positive regulation of T cell migration	Tyrosine-protein kinase ABL1	Homo sapiens (human)
negative regulation of cellular senescence	Tyrosine-protein kinase ABL1	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cell surface receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
MAPK cascade	Epidermal growth factor receptor	Homo sapiens (human)
ossification	Epidermal growth factor receptor	Homo sapiens (human)
embryonic placenta development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
hair follicle development	Epidermal growth factor receptor	Homo sapiens (human)
translation	Epidermal growth factor receptor	Homo sapiens (human)
signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
activation of phospholipase C activity	Epidermal growth factor receptor	Homo sapiens (human)
salivary gland morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
midgut development	Epidermal growth factor receptor	Homo sapiens (human)
learning or memory	Epidermal growth factor receptor	Homo sapiens (human)
circadian rhythm	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Epidermal growth factor receptor	Homo sapiens (human)
diterpenoid metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
cerebral cortex cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell growth	Epidermal growth factor receptor	Homo sapiens (human)
lung development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cell migration	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of superoxide anion generation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
response to cobalamin	Epidermal growth factor receptor	Homo sapiens (human)
response to hydroxyisoflavone	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to reactive oxygen species	Epidermal growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ERBB2-EGFR signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of protein catabolic process	Epidermal growth factor receptor	Homo sapiens (human)
vasodilation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
ovulation cycle	Epidermal growth factor receptor	Homo sapiens (human)
hydrogen peroxide metabolic process	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of apoptotic process	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of MAP kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
tongue development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA repair	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA replication	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of bone resorption	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of vasoconstriction	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Epidermal growth factor receptor	Homo sapiens (human)
regulation of JNK cascade	Epidermal growth factor receptor	Homo sapiens (human)
symbiont entry into host cell	Epidermal growth factor receptor	Homo sapiens (human)
protein autophosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
astrocyte activation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of fibroblast proliferation	Epidermal growth factor receptor	Homo sapiens (human)
digestive tract morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
neuron projection morphogenesis	Epidermal growth factor receptor	Homo sapiens (human)
epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Epidermal growth factor receptor	Homo sapiens (human)
protein insertion into membrane	Epidermal growth factor receptor	Homo sapiens (human)
response to calcium ion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of glial cell proliferation	Epidermal growth factor receptor	Homo sapiens (human)
morphogenesis of an epithelial fold	Epidermal growth factor receptor	Homo sapiens (human)
eyelid development in camera-type eye	Epidermal growth factor receptor	Homo sapiens (human)
response to UV-A	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of mucus secretion	Epidermal growth factor receptor	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to amino acid stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to mechanical stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to cadmium ion	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to xenobiotic stimulus	Epidermal growth factor receptor	Homo sapiens (human)
cellular response to dexamethasone stimulus	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
liver regeneration	Epidermal growth factor receptor	Homo sapiens (human)
cell-cell adhesion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein kinase C activity	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of prolactin secretion	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of miRNA transcription	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
negative regulation of cardiocyte differentiation	Epidermal growth factor receptor	Homo sapiens (human)
neurogenesis	Epidermal growth factor receptor	Homo sapiens (human)
multicellular organism development	Epidermal growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Epidermal growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell activation involved in immune response	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway	Interferon beta	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Interferon beta	Homo sapiens (human)
response to virus	Interferon beta	Homo sapiens (human)
positive regulation of autophagy	Interferon beta	Homo sapiens (human)
cytokine-mediated signaling pathway	Interferon beta	Homo sapiens (human)
natural killer cell activation	Interferon beta	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Interferon beta	Homo sapiens (human)
cellular response to interferon-beta	Interferon beta	Homo sapiens (human)
B cell proliferation	Interferon beta	Homo sapiens (human)
negative regulation of viral genome replication	Interferon beta	Homo sapiens (human)
innate immune response	Interferon beta	Homo sapiens (human)
positive regulation of innate immune response	Interferon beta	Homo sapiens (human)
regulation of MHC class I biosynthetic process	Interferon beta	Homo sapiens (human)
negative regulation of T cell differentiation	Interferon beta	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Interferon beta	Homo sapiens (human)
defense response to virus	Interferon beta	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interferon beta	Homo sapiens (human)
neuron cellular homeostasis	Interferon beta	Homo sapiens (human)
cellular response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
cellular response to virus	Interferon beta	Homo sapiens (human)
negative regulation of Lewy body formation	Interferon beta	Homo sapiens (human)
negative regulation of T-helper 2 cell cytokine production	Interferon beta	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Interferon beta	Homo sapiens (human)
response to exogenous dsRNA	Interferon beta	Homo sapiens (human)
B cell differentiation	Interferon beta	Homo sapiens (human)
natural killer cell activation involved in immune response	Interferon beta	Homo sapiens (human)
adaptive immune response	Interferon beta	Homo sapiens (human)
T cell activation involved in immune response	Interferon beta	Homo sapiens (human)
humoral immune response	Interferon beta	Homo sapiens (human)
positive regulation of T cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
adaptive immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of T cell anergy	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
defense response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
detection of bacterium	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-12 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of interleukin-6 production	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protection from natural killer cell mediated cytotoxicity	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
innate immune response	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
regulation of dendritic cell differentiation	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface receptor signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of protein phosphorylation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
protein phosphorylation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
signal transduction	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
enzyme-linked receptor protein signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
heart development	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
neuromuscular junction development	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
motor neuron axon guidance	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
Schwann cell development	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of cell growth	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
regulation of microtubule-based process	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
immature T cell proliferation in thymus	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
negative regulation of immature T cell proliferation in thymus	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of Rho protein signal transduction	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
intracellular signal transduction	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ERBB2-EGFR signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ERBB2-ERBB4 signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
wound healing	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
myelination	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of MAP kinase activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of translation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
regulation of angiogenesis	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of cell adhesion	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase I	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
oligodendrocyte differentiation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
cellular response to growth factor stimulus	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
semaphorin-plexin signaling pathway	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of protein targeting to membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
neurogenesis	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of MAPK cascade	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
negative regulation of apoptotic process	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of kinase activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
multicellular organism development	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
positive regulation of cell population proliferation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
neuron differentiation	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
cellular response to amyloid-beta	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
protein phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
axon guidance	High affinity nerve growth factor receptor	Homo sapiens (human)
learning or memory	High affinity nerve growth factor receptor	Homo sapiens (human)
circadian rhythm	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of cell population proliferation	High affinity nerve growth factor receptor	Homo sapiens (human)
response to xenobiotic stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
programmed cell death involved in cell development	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of neuron projection development	High affinity nerve growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
olfactory nerve development	High affinity nerve growth factor receptor	Homo sapiens (human)
B cell differentiation	High affinity nerve growth factor receptor	Homo sapiens (human)
response to nutrient levels	High affinity nerve growth factor receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
mechanoreceptor differentiation	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of programmed cell death	High affinity nerve growth factor receptor	Homo sapiens (human)
negative regulation of neuron apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of GTPase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of Ras protein signal transduction	High affinity nerve growth factor receptor	Homo sapiens (human)
protein autophosphorylation	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin TRK receptor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
ephrin receptor signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
sympathetic nervous system development	High affinity nerve growth factor receptor	Homo sapiens (human)
response to axon injury	High affinity nerve growth factor receptor	Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of pain	High affinity nerve growth factor receptor	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
neuron apoptotic process	High affinity nerve growth factor receptor	Homo sapiens (human)
response to hydrostatic pressure	High affinity nerve growth factor receptor	Homo sapiens (human)
response to electrical stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of synapse assembly	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	High affinity nerve growth factor receptor	Homo sapiens (human)
Sertoli cell development	High affinity nerve growth factor receptor	Homo sapiens (human)
axonogenesis involved in innervation	High affinity nerve growth factor receptor	Homo sapiens (human)
behavioral response to formalin induced pain	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	High affinity nerve growth factor receptor	Homo sapiens (human)
cellular response to nicotine	High affinity nerve growth factor receptor	Homo sapiens (human)
cellular response to nerve growth factor stimulus	High affinity nerve growth factor receptor	Homo sapiens (human)
multicellular organism development	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	High affinity nerve growth factor receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	High affinity nerve growth factor receptor	Homo sapiens (human)
signal transduction	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
negative regulation of adenylate cyclase activity	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
G protein-coupled acetylcholine receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
response to nutrient	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cell population proliferation	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of cell population proliferation	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of cell migration	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of superoxide anion generation	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of urine volume	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
negative regulation of calcium ion-dependent exocytosis	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of insulin receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
negative regulation of synaptic transmission	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cell division	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
regulation of calcium ion transport	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
positive regulation of neural precursor cell proliferation	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
negative regulation of apoptotic signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
gamma-aminobutyric acid signaling pathway	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
chromosome segregation	ADP/ATP translocase 2	Homo sapiens (human)
positive regulation of cell population proliferation	ADP/ATP translocase 2	Homo sapiens (human)
adenine transport	ADP/ATP translocase 2	Homo sapiens (human)
B cell differentiation	ADP/ATP translocase 2	Homo sapiens (human)
erythrocyte differentiation	ADP/ATP translocase 2	Homo sapiens (human)
regulation of mitochondrial membrane permeability	ADP/ATP translocase 2	Homo sapiens (human)
adenine nucleotide transport	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrial ADP transmembrane transport	ADP/ATP translocase 2	Homo sapiens (human)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ADP/ATP translocase 2	Homo sapiens (human)
positive regulation of mitophagy	ADP/ATP translocase 2	Homo sapiens (human)
proton transmembrane transport	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrial ATP transmembrane transport	ADP/ATP translocase 2	Homo sapiens (human)
cellular response to leukemia inhibitory factor	ADP/ATP translocase 2	Homo sapiens (human)
adaptive thermogenesis	ADP/ATP translocase 2	Homo sapiens (human)
adaptive immune response	Protein kinase C beta type	Homo sapiens (human)
chromatin remodeling	Protein kinase C beta type	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Protein kinase C beta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C beta type	Homo sapiens (human)
calcium ion transport	Protein kinase C beta type	Homo sapiens (human)
intracellular calcium ion homeostasis	Protein kinase C beta type	Homo sapiens (human)
apoptotic process	Protein kinase C beta type	Homo sapiens (human)
mitotic nuclear membrane disassembly	Protein kinase C beta type	Homo sapiens (human)
signal transduction	Protein kinase C beta type	Homo sapiens (human)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
response to xenobiotic stimulus	Protein kinase C beta type	Homo sapiens (human)
response to glucose	Protein kinase C beta type	Homo sapiens (human)
regulation of glucose transmembrane transport	Protein kinase C beta type	Homo sapiens (human)
negative regulation of glucose transmembrane transport	Protein kinase C beta type	Homo sapiens (human)
regulation of dopamine secretion	Protein kinase C beta type	Homo sapiens (human)
dibenzo-p-dioxin metabolic process	Protein kinase C beta type	Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
positive regulation of insulin secretion	Protein kinase C beta type	Homo sapiens (human)
response to vitamin D	Protein kinase C beta type	Homo sapiens (human)
regulation of growth	Protein kinase C beta type	Homo sapiens (human)
B cell activation	Protein kinase C beta type	Homo sapiens (human)
positive regulation of odontogenesis of dentin-containing tooth	Protein kinase C beta type	Homo sapiens (human)
lipoprotein transport	Protein kinase C beta type	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Protein kinase C beta type	Homo sapiens (human)
post-translational protein modification	Protein kinase C beta type	Homo sapiens (human)
response to ethanol	Protein kinase C beta type	Homo sapiens (human)
positive regulation of angiogenesis	Protein kinase C beta type	Homo sapiens (human)
positive regulation of DNA-templated transcription	Protein kinase C beta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
B cell receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
positive regulation of B cell receptor signaling pathway	Protein kinase C beta type	Homo sapiens (human)
cellular response to carbohydrate stimulus	Protein kinase C beta type	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Protein kinase C beta type	Homo sapiens (human)
regulation of synaptic vesicle exocytosis	Protein kinase C beta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C beta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C beta type	Homo sapiens (human)
positive regulation of MAP kinase activity	Insulin receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Insulin receptor	Homo sapiens (human)
positive regulation of receptor internalization	Insulin receptor	Homo sapiens (human)
heart morphogenesis	Insulin receptor	Homo sapiens (human)
regulation of DNA-templated transcription	Insulin receptor	Homo sapiens (human)
protein phosphorylation	Insulin receptor	Homo sapiens (human)
receptor-mediated endocytosis	Insulin receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Insulin receptor	Homo sapiens (human)
learning	Insulin receptor	Homo sapiens (human)
memory	Insulin receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Insulin receptor	Homo sapiens (human)
insulin receptor signaling pathway	Insulin receptor	Homo sapiens (human)
epidermis development	Insulin receptor	Homo sapiens (human)
male gonad development	Insulin receptor	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Insulin receptor	Homo sapiens (human)
male sex determination	Insulin receptor	Homo sapiens (human)
adrenal gland development	Insulin receptor	Homo sapiens (human)
positive regulation of cell migration	Insulin receptor	Homo sapiens (human)
exocrine pancreas development	Insulin receptor	Homo sapiens (human)
receptor internalization	Insulin receptor	Homo sapiens (human)
activation of protein kinase activity	Insulin receptor	Homo sapiens (human)
activation of protein kinase B activity	Insulin receptor	Homo sapiens (human)
cellular response to insulin stimulus	Insulin receptor	Homo sapiens (human)
glucose homeostasis	Insulin receptor	Homo sapiens (human)
positive regulation of protein-containing complex disassembly	Insulin receptor	Homo sapiens (human)
positive regulation of MAPK cascade	Insulin receptor	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Insulin receptor	Homo sapiens (human)
positive regulation of glycogen biosynthetic process	Insulin receptor	Homo sapiens (human)
positive regulation of glycolytic process	Insulin receptor	Homo sapiens (human)
positive regulation of mitotic nuclear division	Insulin receptor	Homo sapiens (human)
positive regulation of DNA-templated transcription	Insulin receptor	Homo sapiens (human)
regulation of embryonic development	Insulin receptor	Homo sapiens (human)
positive regulation of glucose import	Insulin receptor	Homo sapiens (human)
symbiont entry into host cell	Insulin receptor	Homo sapiens (human)
protein autophosphorylation	Insulin receptor	Homo sapiens (human)
positive regulation of developmental growth	Insulin receptor	Homo sapiens (human)
positive regulation of meiotic cell cycle	Insulin receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Insulin receptor	Homo sapiens (human)
positive regulation of respiratory burst	Insulin receptor	Homo sapiens (human)
cellular response to growth factor stimulus	Insulin receptor	Homo sapiens (human)
dendritic spine maintenance	Insulin receptor	Homo sapiens (human)
amyloid-beta clearance	Insulin receptor	Homo sapiens (human)
transport across blood-brain barrier	Insulin receptor	Homo sapiens (human)
neuron projection maintenance	Insulin receptor	Homo sapiens (human)
regulation of female gonad development	Insulin receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Insulin receptor	Homo sapiens (human)
multicellular organism development	Insulin receptor	Homo sapiens (human)
positive regulation of kinase activity	Insulin receptor	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
intracellular zinc ion homeostasis	Tyrosine-protein kinase Lck	Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic process	Tyrosine-protein kinase Lck	Homo sapiens (human)
response to xenobiotic stimulus	Tyrosine-protein kinase Lck	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
hemopoiesis	Tyrosine-protein kinase Lck	Homo sapiens (human)
platelet activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell differentiation	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of heterotypic cell-cell adhesion	Tyrosine-protein kinase Lck	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Lck	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Tyrosine-protein kinase Lck	Homo sapiens (human)
Fc-gamma receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of T cell activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Lck	Homo sapiens (human)
release of sequestered calcium ion into cytosol	Tyrosine-protein kinase Lck	Homo sapiens (human)
regulation of lymphocyte activation	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of leukocyte cell-cell adhesion	Tyrosine-protein kinase Lck	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Lck	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase Lck	Homo sapiens (human)
response to singlet oxygen	Tyrosine-protein kinase Fyn	Homo sapiens (human)
neuron migration	Tyrosine-protein kinase Fyn	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
heart process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
calcium ion transport	Tyrosine-protein kinase Fyn	Homo sapiens (human)
G protein-coupled glutamate receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
axon guidance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
learning	Tyrosine-protein kinase Fyn	Homo sapiens (human)
feeding behavior	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of cell shape	Tyrosine-protein kinase Fyn	Homo sapiens (human)
gene expression	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of gene expression	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of hydrogen peroxide biosynthetic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of neuron projection development	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein ubiquitination	Tyrosine-protein kinase Fyn	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein catabolic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
forebrain development	Tyrosine-protein kinase Fyn	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of protein ubiquitination	Tyrosine-protein kinase Fyn	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of protein catabolic process	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Tyrosine-protein kinase Fyn	Homo sapiens (human)
response to ethanol	Tyrosine-protein kinase Fyn	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ephrin receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite morphogenesis	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
activated T cell proliferation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
modulation of chemical synaptic transmission	Tyrosine-protein kinase Fyn	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Fyn	Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of pain	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to hydrogen peroxide	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein targeting to membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendritic spine maintenance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein localization to nucleus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of glutamate receptor signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
negative regulation of dendritic spine maintenance	Tyrosine-protein kinase Fyn	Homo sapiens (human)
response to amyloid-beta	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to amyloid-beta	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to L-glutamate	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cellular response to glycine	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of protein localization to membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
regulation of calcium ion import across plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Fyn	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 1	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 1	Homo sapiens (human)
microtubule cytoskeleton organization	Cyclin-dependent kinase 1	Homo sapiens (human)
DNA replication	Cyclin-dependent kinase 1	Homo sapiens (human)
DNA repair	Cyclin-dependent kinase 1	Homo sapiens (human)
chromatin remodeling	Cyclin-dependent kinase 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 1	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 1	Homo sapiens (human)
apoptotic process	Cyclin-dependent kinase 1	Homo sapiens (human)
DNA damage response	Cyclin-dependent kinase 1	Homo sapiens (human)
mitotic nuclear membrane disassembly	Cyclin-dependent kinase 1	Homo sapiens (human)
centrosome cycle	Cyclin-dependent kinase 1	Homo sapiens (human)
pronuclear fusion	Cyclin-dependent kinase 1	Homo sapiens (human)
response to xenobiotic stimulus	Cyclin-dependent kinase 1	Homo sapiens (human)
response to toxic substance	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of gene expression	Cyclin-dependent kinase 1	Homo sapiens (human)
negative regulation of gene expression	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 1	Homo sapiens (human)
regulation of Schwann cell differentiation	Cyclin-dependent kinase 1	Homo sapiens (human)
response to amine	Cyclin-dependent kinase 1	Homo sapiens (human)
response to activity	Cyclin-dependent kinase 1	Homo sapiens (human)
cell migration	Cyclin-dependent kinase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	Cyclin-dependent kinase 1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Cyclin-dependent kinase 1	Homo sapiens (human)
chromosome condensation	Cyclin-dependent kinase 1	Homo sapiens (human)
epithelial cell differentiation	Cyclin-dependent kinase 1	Homo sapiens (human)
animal organ regeneration	Cyclin-dependent kinase 1	Homo sapiens (human)
protein localization to kinetochore	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of protein import into nucleus	Cyclin-dependent kinase 1	Homo sapiens (human)
regulation of circadian rhythm	Cyclin-dependent kinase 1	Homo sapiens (human)
negative regulation of apoptotic process	Cyclin-dependent kinase 1	Homo sapiens (human)
response to ethanol	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of DNA replication	Cyclin-dependent kinase 1	Homo sapiens (human)
regulation of embryonic development	Cyclin-dependent kinase 1	Homo sapiens (human)
response to cadmium ion	Cyclin-dependent kinase 1	Homo sapiens (human)
response to copper ion	Cyclin-dependent kinase 1	Homo sapiens (human)
symbiont entry into host cell	Cyclin-dependent kinase 1	Homo sapiens (human)
fibroblast proliferation	Cyclin-dependent kinase 1	Homo sapiens (human)
rhythmic process	Cyclin-dependent kinase 1	Homo sapiens (human)
response to axon injury	Cyclin-dependent kinase 1	Homo sapiens (human)
cell division	Cyclin-dependent kinase 1	Homo sapiens (human)
ventricular cardiac muscle cell development	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of mitotic sister chromatid segregation	Cyclin-dependent kinase 1	Homo sapiens (human)
protein-containing complex assembly	Cyclin-dependent kinase 1	Homo sapiens (human)
cellular response to hydrogen peroxide	Cyclin-dependent kinase 1	Homo sapiens (human)
ERK1 and ERK2 cascade	Cyclin-dependent kinase 1	Homo sapiens (human)
cellular response to organic cyclic compound	Cyclin-dependent kinase 1	Homo sapiens (human)
Golgi disassembly	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of protein localization to nucleus	Cyclin-dependent kinase 1	Homo sapiens (human)
regulation of attachment of mitotic spindle microtubules to kinetochore	Cyclin-dependent kinase 1	Homo sapiens (human)
microtubule cytoskeleton organization involved in mitosis	Cyclin-dependent kinase 1	Homo sapiens (human)
positive regulation of mitochondrial ATP synthesis coupled electron transport	Cyclin-dependent kinase 1	Homo sapiens (human)
mitotic G2 DNA damage checkpoint signaling	Cyclin-dependent kinase 1	Homo sapiens (human)
protein deubiquitination	Cyclin-dependent kinase 1	Homo sapiens (human)
glycogen metabolic process	Glycogen phosphorylase, liver form	Homo sapiens (human)
5-phosphoribose 1-diphosphate biosynthetic process	Glycogen phosphorylase, liver form	Homo sapiens (human)
response to bacterium	Glycogen phosphorylase, liver form	Homo sapiens (human)
glucose homeostasis	Glycogen phosphorylase, liver form	Homo sapiens (human)
necroptotic process	Glycogen phosphorylase, liver form	Homo sapiens (human)
glycogen catabolic process	Glycogen phosphorylase, liver form	Homo sapiens (human)
microtubule bundle formation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
centrosome cycle	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of cell shape	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
positive regulation of neuron projection development	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of cell adhesion	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
positive regulation of microtubule polymerization	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of cell population proliferation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of mast cell degranulation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of cell differentiation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
positive regulation of myeloid cell differentiation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
positive regulation of monocyte differentiation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
protein autophosphorylation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
myoblast proliferation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cardiac muscle cell proliferation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of vesicle-mediated transport	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cellular response to vitamin D	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
regulation of cell motility	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
chemotaxis	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cell adhesion	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
purine ribonucleoside salvage	Adenine phosphoribosyltransferase	Homo sapiens (human)
grooming behavior	Adenine phosphoribosyltransferase	Homo sapiens (human)
GMP salvage	Adenine phosphoribosyltransferase	Homo sapiens (human)
IMP salvage	Adenine phosphoribosyltransferase	Homo sapiens (human)
AMP salvage	Adenine phosphoribosyltransferase	Homo sapiens (human)
adenine salvage	Adenine phosphoribosyltransferase	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase Yes	Homo sapiens (human)
regulation of glucose transmembrane transport	Tyrosine-protein kinase Yes	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Yes	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Tyrosine-protein kinase Yes	Homo sapiens (human)
protein modification process	Tyrosine-protein kinase Yes	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase Yes	Homo sapiens (human)
regulation of vascular permeability	Tyrosine-protein kinase Yes	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Tyrosine-protein kinase Yes	Homo sapiens (human)
ephrin receptor signaling pathway	Tyrosine-protein kinase Yes	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Yes	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Yes	Homo sapiens (human)
cellular response to retinoic acid	Tyrosine-protein kinase Yes	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Tyrosine-protein kinase Yes	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Yes	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase Yes	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Yes	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Yes	Homo sapiens (human)
DNA damage checkpoint signaling	Tyrosine-protein kinase Lyn	Homo sapiens (human)
B cell homeostasis	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of cytokine production	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of protein phosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of protein phosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of protein phosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase Lyn	Homo sapiens (human)
Fc receptor mediated stimulatory signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
tolerance induction to self antigen	Tyrosine-protein kinase Lyn	Homo sapiens (human)
histamine secretion by mast cell	Tyrosine-protein kinase Lyn	Homo sapiens (human)
platelet degranulation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of myeloid leukocyte differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
immune response-regulating cell surface receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
Fc receptor mediated inhibitory signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of B cell apoptotic process	Tyrosine-protein kinase Lyn	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
DNA damage response	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to sterol depletion	Tyrosine-protein kinase Lyn	Homo sapiens (human)
signal transduction	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of cell population proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of cell population proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to xenobiotic stimulus	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to toxic substance	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to hormone	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to carbohydrate	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of neuron projection development	Tyrosine-protein kinase Lyn	Homo sapiens (human)
oligodendrocyte development	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to organic cyclic compound	Tyrosine-protein kinase Lyn	Homo sapiens (human)
fatty acid transport	Tyrosine-protein kinase Lyn	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
erythrocyte differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
eosinophil differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of cell migration	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of B cell proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to insulin	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of mast cell activation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of toll-like receptor 2 signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of toll-like receptor 4 signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cellular response to heat	Tyrosine-protein kinase Lyn	Homo sapiens (human)
interleukin-5-mediated signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase Lyn	Homo sapiens (human)
C-X-C chemokine receptor CXCR4 signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to amino acid	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of mast cell degranulation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of MAP kinase activity	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of MAPK cascade	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of erythrocyte differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
protein autophosphorylation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
ephrin receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
response to axon injury	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of immune response	Tyrosine-protein kinase Lyn	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of B cell receptor signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
leukocyte migration	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosol	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of glial cell proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of Fc receptor mediated stimulatory signaling pathway	Tyrosine-protein kinase Lyn	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of oligodendrocyte progenitor proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of mast cell proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of mast cell proliferation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cellular response to retinoic acid	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of monocyte chemotaxis	Tyrosine-protein kinase Lyn	Homo sapiens (human)
regulation of platelet aggregation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
dendritic cell differentiation	Tyrosine-protein kinase Lyn	Homo sapiens (human)
negative regulation of intracellular signal transduction	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Tyrosine-protein kinase Lyn	Homo sapiens (human)
positive regulation of dendritic cell apoptotic process	Tyrosine-protein kinase Lyn	Homo sapiens (human)
neuron projection development	Tyrosine-protein kinase Lyn	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase Lyn	Homo sapiens (human)
MAPK cascade	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
ureteric bud development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
neural crest cell migration	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
embryonic epithelial tube formation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
protein phosphorylation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
homophilic cell adhesion via plasma membrane adhesion molecules	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
neuron cell-cell adhesion	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
signal transduction	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
axon guidance	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
posterior midgut development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
response to xenobiotic stimulus	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of gene expression	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of neuron projection development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of neuron maturation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
regulation of cell adhesion	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of cell migration	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT protein	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
membrane protein proteolysis	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of cell adhesion mediated by integrin	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
ureter maturation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
glial cell-derived neurotrophic factor receptor signaling pathway	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
neuron maturation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of MAPK cascade	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of cell size	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of DNA-templated transcription	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
response to pain	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
enteric nervous system development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
regulation of axonogenesis	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
retina development in camera-type eye	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
innervation	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
Peyer's patch morphogenesis	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
cellular response to retinoic acid	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of metanephric glomerulus development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
lymphocyte migration into lymphoid organs	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
GDF15-GFRAL signaling pathway	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
positive regulation of kinase activity	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
multicellular organism development	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cardiac atrium development	Insulin-like growth factor 1 receptor	Homo sapiens (human)
immune response	Insulin-like growth factor 1 receptor	Homo sapiens (human)
signal transduction	Insulin-like growth factor 1 receptor	Homo sapiens (human)
axonogenesis	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin receptor signaling pathway	Insulin-like growth factor 1 receptor	Homo sapiens (human)
negative regulation of muscle cell apoptotic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cerebellum development	Insulin-like growth factor 1 receptor	Homo sapiens (human)
hippocampus development	Insulin-like growth factor 1 receptor	Homo sapiens (human)
establishment of cell polarity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of cell migration	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of cytokinesis	Insulin-like growth factor 1 receptor	Homo sapiens (human)
response to vitamin E	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of osteoblast proliferation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to zinc ion starvation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
response to nicotine	Insulin-like growth factor 1 receptor	Homo sapiens (human)
negative regulation of apoptotic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of protein-containing complex disassembly	Insulin-like growth factor 1 receptor	Homo sapiens (human)
response to alkaloid	Insulin-like growth factor 1 receptor	Homo sapiens (human)
negative regulation of MAPK cascade	Insulin-like growth factor 1 receptor	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Insulin-like growth factor 1 receptor	Homo sapiens (human)
estrous cycle	Insulin-like growth factor 1 receptor	Homo sapiens (human)
transcytosis	Insulin-like growth factor 1 receptor	Homo sapiens (human)
response to ethanol	Insulin-like growth factor 1 receptor	Homo sapiens (human)
regulation of JNK cascade	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein autophosphorylation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of axon regeneration	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of DNA metabolic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to mechanical stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to estradiol stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to progesterone stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to testosterone stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to dexamethasone stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of steroid hormone biosynthetic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular senescence	Insulin-like growth factor 1 receptor	Homo sapiens (human)
dendritic spine maintenance	Insulin-like growth factor 1 receptor	Homo sapiens (human)
amyloid-beta clearance	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Insulin-like growth factor 1 receptor	Homo sapiens (human)
response to L-glutamate	Insulin-like growth factor 1 receptor	Homo sapiens (human)
negative regulation of hepatocyte apoptotic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to aldosterone	Insulin-like growth factor 1 receptor	Homo sapiens (human)
negative regulation of cholangiocyte apoptotic process	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to angiotensin	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to amyloid-beta	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to insulin-like growth factor stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
multicellular organism development	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of kinase activity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cellular response to glucose stimulus	Insulin-like growth factor 1 receptor	Homo sapiens (human)
positive regulation of MAPK cascade	Insulin-like growth factor 1 receptor	Homo sapiens (human)
cotranslational protein targeting to membrane	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
intracellular protein transport	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
protein targeting to ER	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
mitochondrial electron transport, ubiquinol to cytochrome c	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
response to glucagon	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
cellular respiration	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
proton transmembrane transport	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
endothelial cell morphogenesis	Hepatocyte growth factor receptor	Homo sapiens (human)
signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of autophagy	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of microtubule polymerization	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of Rho protein signal transduction	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
branching morphogenesis of an epithelial tube	Hepatocyte growth factor receptor	Homo sapiens (human)
positive chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of stress fiber assembly	Hepatocyte growth factor receptor	Homo sapiens (human)
excitatory postsynaptic potential	Hepatocyte growth factor receptor	Homo sapiens (human)
establishment of skin barrier	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of thrombin-activated receptor signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin-plexin signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of hydrogen peroxide-mediated programmed cell death	Hepatocyte growth factor receptor	Homo sapiens (human)
negative regulation of guanyl-nucleotide exchange factor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Hepatocyte growth factor receptor	Homo sapiens (human)
liver development	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Hepatocyte growth factor receptor	Homo sapiens (human)
phagocytosis	Hepatocyte growth factor receptor	Homo sapiens (human)
multicellular organism development	Hepatocyte growth factor receptor	Homo sapiens (human)
neuron differentiation	Hepatocyte growth factor receptor	Homo sapiens (human)
positive regulation of kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
cell migration	Hepatocyte growth factor receptor	Homo sapiens (human)
pancreas development	Hepatocyte growth factor receptor	Homo sapiens (human)
nervous system development	Hepatocyte growth factor receptor	Homo sapiens (human)
leukocyte migration involved in immune response	Tyrosine-protein kinase HCK	Homo sapiens (human)
innate immune response-activating signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase HCK	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase HCK	Homo sapiens (human)
inflammatory response	Tyrosine-protein kinase HCK	Homo sapiens (human)
cell adhesion	Tyrosine-protein kinase HCK	Homo sapiens (human)
integrin-mediated signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
mesoderm development	Tyrosine-protein kinase HCK	Homo sapiens (human)
positive regulation of cell population proliferation	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of cell shape	Tyrosine-protein kinase HCK	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase HCK	Homo sapiens (human)
cytokine-mediated signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
positive regulation of actin filament polymerization	Tyrosine-protein kinase HCK	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of actin cytoskeleton organization	Tyrosine-protein kinase HCK	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase HCK	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase HCK	Homo sapiens (human)
negative regulation of apoptotic process	Tyrosine-protein kinase HCK	Homo sapiens (human)
leukocyte degranulation	Tyrosine-protein kinase HCK	Homo sapiens (human)
respiratory burst after phagocytosis	Tyrosine-protein kinase HCK	Homo sapiens (human)
protein autophosphorylation	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of inflammatory response	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of phagocytosis	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of DNA-binding transcription factor activity	Tyrosine-protein kinase HCK	Homo sapiens (human)
type II interferon-mediated signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
regulation of podosome assembly	Tyrosine-protein kinase HCK	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase HCK	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase HCK	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase HCK	Homo sapiens (human)
signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell population proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phospholipase C activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell migration	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphoprotein phosphatase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
regulation of actin cytoskeleton organization	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in vasculogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
aorta morphogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of MAP kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of mitotic nuclear division	Platelet-derived growth factor receptor beta	Homo sapiens (human)
phosphatidylinositol metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein autophosphorylation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cardiac myofibril assembly	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell migration involved in coronary angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
retina vasculature development in camera-type eye	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Platelet-derived growth factor receptor beta	Homo sapiens (human)
smooth muscle cell chemotaxis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular mesangial cell proliferation involved in metanephros development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
metanephric glomerular capillary formation	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of calcium ion import	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Platelet-derived growth factor receptor beta	Homo sapiens (human)
positive regulation of kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
angiogenesis	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Platelet-derived growth factor receptor beta	Homo sapiens (human)
multicellular organism development	Platelet-derived growth factor receptor beta	Homo sapiens (human)
regulation of TOR signaling	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
regulation of proteasomal ubiquitin-dependent protein catabolic process	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
protein modification process	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
MAPK cascade	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
glycogen catabolic process	Glycogen phosphorylase, brain form	Homo sapiens (human)
negative regulation of cellular extravasation	Breakpoint cluster region protein	Homo sapiens (human)
renal system process	Breakpoint cluster region protein	Homo sapiens (human)
protein phosphorylation	Breakpoint cluster region protein	Homo sapiens (human)
phagocytosis	Breakpoint cluster region protein	Homo sapiens (human)
signal transduction	Breakpoint cluster region protein	Homo sapiens (human)
small GTPase-mediated signal transduction	Breakpoint cluster region protein	Homo sapiens (human)
brain development	Breakpoint cluster region protein	Homo sapiens (human)
actin cytoskeleton organization	Breakpoint cluster region protein	Homo sapiens (human)
keratinocyte differentiation	Breakpoint cluster region protein	Homo sapiens (human)
regulation of Rho protein signal transduction	Breakpoint cluster region protein	Homo sapiens (human)
inner ear morphogenesis	Breakpoint cluster region protein	Homo sapiens (human)
regulation of vascular permeability	Breakpoint cluster region protein	Homo sapiens (human)
neutrophil degranulation	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of neutrophil degranulation	Breakpoint cluster region protein	Homo sapiens (human)
focal adhesion assembly	Breakpoint cluster region protein	Homo sapiens (human)
homeostasis of number of cells	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of inflammatory response	Breakpoint cluster region protein	Homo sapiens (human)
positive regulation of phagocytosis	Breakpoint cluster region protein	Homo sapiens (human)
modulation of chemical synaptic transmission	Breakpoint cluster region protein	Homo sapiens (human)
neuromuscular process controlling balance	Breakpoint cluster region protein	Homo sapiens (human)
regulation of small GTPase mediated signal transduction	Breakpoint cluster region protein	Homo sapiens (human)
regulation of cell cycle	Breakpoint cluster region protein	Homo sapiens (human)
definitive hemopoiesis	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of respiratory burst	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of blood vessel remodeling	Breakpoint cluster region protein	Homo sapiens (human)
intracellular protein transmembrane transport	Breakpoint cluster region protein	Homo sapiens (human)
cellular response to lipopolysaccharide	Breakpoint cluster region protein	Homo sapiens (human)
activation of GTPase activity	Breakpoint cluster region protein	Homo sapiens (human)
macrophage migration	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of macrophage migration	Breakpoint cluster region protein	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Breakpoint cluster region protein	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
regulation of transmembrane transporter activity	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
negative regulation of innate immune response	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
protein stabilization	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
vitamin D receptor signaling pathway	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
cellular response to type II interferon	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of brown fat cell differentiation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
regulation of hematopoietic stem cell proliferation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of TORC1 signaling	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of cardioblast proliferation	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
cellular detoxification	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Fibroblast growth factor receptor 1	Homo sapiens (human)
MAPK cascade	Fibroblast growth factor receptor 1	Homo sapiens (human)
skeletal system development	Fibroblast growth factor receptor 1	Homo sapiens (human)
angiogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
ureteric bud development	Fibroblast growth factor receptor 1	Homo sapiens (human)
in utero embryonic development	Fibroblast growth factor receptor 1	Homo sapiens (human)
organ induction	Fibroblast growth factor receptor 1	Homo sapiens (human)
neuron migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
epithelial to mesenchymal transition	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
chondrocyte differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein phosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
sensory perception of sound	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cell population proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
mesenchymal cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
gene expression	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phospholipase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phospholipase C activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of phosphate transport	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of neuron projection development	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
ventricular zone neuroblast division	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell projection assembly	Fibroblast growth factor receptor 1	Homo sapiens (human)
embryonic limb morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
midbrain development	Fibroblast growth factor receptor 1	Homo sapiens (human)
neuron projection development	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	Fibroblast growth factor receptor 1	Homo sapiens (human)
inner ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
outer ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
middle ear morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
chordate embryonic development	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAP kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAPK cascade	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Fibroblast growth factor receptor 1	Homo sapiens (human)
cellular response to fibroblast growth factor stimulus	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of neuron differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein autophosphorylation	Fibroblast growth factor receptor 1	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Fibroblast growth factor receptor 1	Homo sapiens (human)
paraxial mesoderm development	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of lateral mesodermal cell fate specification	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell maturation	Fibroblast growth factor receptor 1	Homo sapiens (human)
skeletal system morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
stem cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Fibroblast growth factor receptor 1	Homo sapiens (human)
calcium ion homeostasis	Fibroblast growth factor receptor 1	Homo sapiens (human)
cardiac muscle cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
auditory receptor cell development	Fibroblast growth factor receptor 1	Homo sapiens (human)
branching involved in salivary gland morphogenesis	Fibroblast growth factor receptor 1	Homo sapiens (human)
lung-associated mesenchyme development	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	Fibroblast growth factor receptor 1	Homo sapiens (human)
vitamin D3 metabolic process	Fibroblast growth factor receptor 1	Homo sapiens (human)
diphosphate metabolic process	Fibroblast growth factor receptor 1	Homo sapiens (human)
cementum mineralization	Fibroblast growth factor receptor 1	Homo sapiens (human)
stem cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
negative regulation of fibroblast growth factor production	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of mitotic cell cycle DNA replication	Fibroblast growth factor receptor 1	Homo sapiens (human)
response to sodium phosphate	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of vascular endothelial cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of stem cell proliferation	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of parathyroid hormone secretion	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Fibroblast growth factor receptor 1	Homo sapiens (human)
regulation of extrinsic apoptotic signaling pathway in absence of ligand	Fibroblast growth factor receptor 1	Homo sapiens (human)
multicellular organism development	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of cell differentiation	Fibroblast growth factor receptor 1	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Fibroblast growth factor receptor 1	Homo sapiens (human)
positive regulation of kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
hematopoietic progenitor cell differentiation	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topological change	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA ligation	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA damage response	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromosome segregation	DNA topoisomerase 2-alpha	Homo sapiens (human)
female meiotic nuclear division	DNA topoisomerase 2-alpha	Homo sapiens (human)
apoptotic chromosome condensation	DNA topoisomerase 2-alpha	Homo sapiens (human)
embryonic cleavage	DNA topoisomerase 2-alpha	Homo sapiens (human)
regulation of circadian rhythm	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of apoptotic process	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	DNA topoisomerase 2-alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	DNA topoisomerase 2-alpha	Homo sapiens (human)
rhythmic process	DNA topoisomerase 2-alpha	Homo sapiens (human)
negative regulation of DNA duplex unwinding	DNA topoisomerase 2-alpha	Homo sapiens (human)
resolution of meiotic recombination intermediates	DNA topoisomerase 2-alpha	Homo sapiens (human)
sister chromatid segregation	DNA topoisomerase 2-alpha	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 4	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 4	Homo sapiens (human)
positive regulation of cell population proliferation	Cyclin-dependent kinase 4	Homo sapiens (human)
response to xenobiotic stimulus	Cyclin-dependent kinase 4	Homo sapiens (human)
regulation of gene expression	Cyclin-dependent kinase 4	Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 4	Homo sapiens (human)
positive regulation of fibroblast proliferation	Cyclin-dependent kinase 4	Homo sapiens (human)
cell division	Cyclin-dependent kinase 4	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 4	Homo sapiens (human)
regulation of transcription initiation by RNA polymerase II	Cyclin-dependent kinase 4	Homo sapiens (human)
regulation of type B pancreatic cell proliferation	Cyclin-dependent kinase 4	Homo sapiens (human)
cellular response to lipopolysaccharide	Cyclin-dependent kinase 4	Homo sapiens (human)
cellular response to interleukin-4	Cyclin-dependent kinase 4	Homo sapiens (human)
cellular response to phorbol 13-acetate 12-myristate	Cyclin-dependent kinase 4	Homo sapiens (human)
cellular response to ionomycin	Cyclin-dependent kinase 4	Homo sapiens (human)
response to organic substance	Cyclin-dependent kinase 4	Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 4	Homo sapiens (human)
signal transduction	Cyclin-dependent kinase 4	Homo sapiens (human)
apoptotic process	ADP/ATP translocase 3	Homo sapiens (human)
mitochondrial ADP transmembrane transport	ADP/ATP translocase 3	Homo sapiens (human)
mitochondrial ATP transmembrane transport	ADP/ATP translocase 3	Homo sapiens (human)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ADP/ATP translocase 3	Homo sapiens (human)
GMP biosynthetic process	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
GTP biosynthetic process	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
circadian rhythm	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
lymphocyte proliferation	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
cellular response to interleukin-4	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
'de novo' XMP biosynthetic process	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
primary ovarian follicle growth	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of cytokine production	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
signal transduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
signal complex assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
integrin-mediated signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
spermatogenesis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
learning or memory	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to xenobiotic stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to mechanical stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to acidic pH	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of gene expression	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of epithelial cell migration	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of epithelial cell migration	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of glucose metabolic process	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of protein processing	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
skeletal muscle cell proliferation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
macroautophagy	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of cell-cell adhesion	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
platelet activation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
forebrain development	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
T cell costimulation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein destabilization	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to nutrient levels	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to insulin stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of intracellular estrogen receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of integrin activation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of toll-like receptor 3 signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
adherens junction organization	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of dephosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of hippo signaling	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
intracellular signal transduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
entry of bacterium into host cell	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
osteoclast development	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ERBB2 signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
angiotensin-activated signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
odontogenesis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of apoptotic process	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of apoptotic process	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of vascular permeability	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
stress fiber assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
transcytosis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of bone resorption	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
bone resorption	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of Notch signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of bone resorption	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of Ras protein signal transduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of insulin receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein autophosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
neurotrophin TRK receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ephrin receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
focal adhesion assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
oogenesis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
progesterone receptor signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
leukocyte migration	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of small GTPase mediated signal transduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of protein transport	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to mineralocorticoid	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
myoblast proliferation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to electrical stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of focal adhesion assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of mitochondrial depolarization	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of telomerase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
uterus development	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
branching involved in mammary gland duct morphogenesis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of cell projection assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
intestinal epithelial cell development	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
interleukin-6-mediated signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to hydrogen peroxide	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
response to interleukin-1	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to lipopolysaccharide	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to peptide hormone stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to progesterone stimulus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to fatty acid	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to hypoxia	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to fluid shear stress	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of podosome assembly	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
DNA biosynthetic process	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of protein serine/threonine kinase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cell-cell adhesion	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of protein localization to nucleus	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of non-membrane spanning protein tyrosine kinase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of TORC1 signaling	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cellular response to prolactin	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of male germ cell proliferation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of ovarian follicle development	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of lamellipodium morphogenesis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
positive regulation of platelet-derived growth factor receptor-beta signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of early endosome to late endosome transport	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of anoikis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of caveolin-mediated endocytosis	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cell differentiation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cell adhesion	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
innate immune response	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein phosphorylation	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
symbiont entry into host cell	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
regulation of protein phosphorylation	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
intracellular signal transduction	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP/PKA signal transduction	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
negative regulation of cAMP-dependent protein kinase activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
MAPK cascade	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
myeloid progenitor cell differentiation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
visual learning	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
animal organ morphogenesis	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of gene expression	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
negative regulation of fibroblast migration	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of glucose transmembrane transport	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
synaptic vesicle exocytosis	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
thyroid gland development	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
T cell differentiation in thymus	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
somatic stem cell population maintenance	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
regulation of cell population proliferation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
stress fiber assembly	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
CD4-positive, alpha-beta T cell differentiation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
response to peptide hormone	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
negative regulation of neuron apoptotic process	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
regulation of T cell differentiation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
thymus development	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of axon regeneration	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of axonogenesis	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
T cell receptor signaling pathway	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of stress fiber assembly	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
response to cAMP	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
long-term synaptic potentiation	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
head morphogenesis	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
face development	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
ERK1 and ERK2 cascade	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cellular response to calcium ion	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cellular response to xenobiotic stimulus	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
endothelial cell apoptotic process	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
establishment of protein localization to membrane	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreading	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cellular response to nerve growth factor stimulus	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
negative regulation of synaptic vesicle exocytosis	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
glycogen metabolic process	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
glycogen biosynthetic process	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
glycogen catabolic process	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
generation of precursor metabolites and energy	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
protein phosphorylation	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
positive regulation of glycogen catabolic process	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
quinone catabolic process	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
microtubule cytoskeleton organization	Tyrosine-protein kinase Fer	Homo sapiens (human)
regulation of protein phosphorylation	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Fer	Homo sapiens (human)
tyrosine phosphorylation of STAT protein	Tyrosine-protein kinase Fer	Homo sapiens (human)
germ cell development	Tyrosine-protein kinase Fer	Homo sapiens (human)
positive regulation of cell population proliferation	Tyrosine-protein kinase Fer	Homo sapiens (human)
insulin receptor signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
regulation of lamellipodium assembly	Tyrosine-protein kinase Fer	Homo sapiens (human)
regulation of fibroblast migration	Tyrosine-protein kinase Fer	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase Fer	Homo sapiens (human)
cytokine-mediated signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
actin cytoskeleton organization	Tyrosine-protein kinase Fer	Homo sapiens (human)
positive regulation of cell migration	Tyrosine-protein kinase Fer	Homo sapiens (human)
positive regulation of actin filament polymerization	Tyrosine-protein kinase Fer	Homo sapiens (human)
response to lipopolysaccharide	Tyrosine-protein kinase Fer	Homo sapiens (human)
negative regulation of mast cell activation involved in immune response	Tyrosine-protein kinase Fer	Homo sapiens (human)
adherens junction assembly	Tyrosine-protein kinase Fer	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Tyrosine-protein kinase Fer	Homo sapiens (human)
cellular response to reactive oxygen species	Tyrosine-protein kinase Fer	Homo sapiens (human)
extracellular matrix-cell signaling	Tyrosine-protein kinase Fer	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Fer	Homo sapiens (human)
cellular response to macrophage colony-stimulating factor stimulus	Tyrosine-protein kinase Fer	Homo sapiens (human)
response to platelet-derived growth factor	Tyrosine-protein kinase Fer	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
Kit signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
regulation of epidermal growth factor receptor signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
cell-cell adhesion mediated by cadherin	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein autophosphorylation	Tyrosine-protein kinase Fer	Homo sapiens (human)
platelet-derived growth factor receptor signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
diapedesis	Tyrosine-protein kinase Fer	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Tyrosine-protein kinase Fer	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Tyrosine-protein kinase Fer	Homo sapiens (human)
Sertoli cell development	Tyrosine-protein kinase Fer	Homo sapiens (human)
interleukin-6-mediated signaling pathway	Tyrosine-protein kinase Fer	Homo sapiens (human)
seminiferous tubule development	Tyrosine-protein kinase Fer	Homo sapiens (human)
adherens junction disassembly	Tyrosine-protein kinase Fer	Homo sapiens (human)
cell adhesion	Tyrosine-protein kinase Fer	Homo sapiens (human)
chemotaxis	Tyrosine-protein kinase Fer	Homo sapiens (human)
angiogenesis	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Protein kinase C alpha type	Homo sapiens (human)
desmosome assembly	Protein kinase C alpha type	Homo sapiens (human)
chromatin remodeling	Protein kinase C alpha type	Homo sapiens (human)
protein phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
mitotic nuclear membrane disassembly	Protein kinase C alpha type	Homo sapiens (human)
cell adhesion	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of endothelial cell migration	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cardiac muscle hypertrophy	Protein kinase C alpha type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
peptidyl-threonine phosphorylation	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cell migration	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of lipopolysaccharide-mediated signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C alpha type	Homo sapiens (human)
regulation of mRNA stability	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Protein kinase C alpha type	Homo sapiens (human)
post-translational protein modification	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of macrophage differentiation	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of angiogenesis	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of bone resorption	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of cell adhesion	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of mitotic cell cycle	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Protein kinase C alpha type	Homo sapiens (human)
response to interleukin-1	Protein kinase C alpha type	Homo sapiens (human)
regulation of platelet aggregation	Protein kinase C alpha type	Homo sapiens (human)
apoptotic signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of angiotensin-activated signaling pathway	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of dense core granule biogenesis	Protein kinase C alpha type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C alpha type	Homo sapiens (human)
positive regulation of insulin secretion	Protein kinase C alpha type	Homo sapiens (human)
mesoderm formation	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
neural tube closure	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of heart rate	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
renal water homeostasis	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
mRNA processing	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein phosphorylation	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein export from nucleus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of macroautophagy	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
peptidyl-serine phosphorylation	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cytokine-mediated signaling pathway	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
positive regulation of insulin secretion	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
negative regulation of interleukin-2 production	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
high-density lipoprotein particle assembly	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to heat	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
mitochondrial protein catabolic process	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of osteoblast differentiation	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
positive regulation of gluconeogenesis	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
negative regulation of smoothened signaling pathway	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
positive regulation of protein export from nucleus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
sperm capacitation	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
positive regulation of calcium-mediated signaling	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of cell cycle	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of cardiac muscle contraction	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of proteasomal protein catabolic process	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to cold	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of protein processing	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to glucose stimulus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to parathyroid hormone stimulus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to glucagon stimulus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cellular response to epinephrine stimulus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cell communication by electrical coupling involved in cardiac conduction	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
postsynaptic modulation of chemical synaptic transmission	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of cardiac conduction	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
negative regulation of TORC1 signaling	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
negative regulation of glycolytic process through fructose-6-phosphate	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein localization to lipid droplet	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
regulation of bicellular tight junction assembly	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein kinase A signaling	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
response to hypoxia	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
in utero embryonic development	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription-coupled nucleotide-excision repair	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
nucleotide-excision repair	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
regulation of transcription by RNA polymerase II	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription elongation by RNA polymerase I	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription by RNA polymerase II	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription initiation at RNA polymerase II promoter	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
apoptotic process	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
response to oxidative stress	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
chromosome segregation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
determination of adult lifespan	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
UV protection	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
post-embryonic development	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
spinal cord development	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
extracellular matrix organization	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
bone mineralization	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
central nervous system myelin formation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
DNA duplex unwinding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
multicellular organism growth	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
hair cell differentiation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
embryonic cleavage	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
erythrocyte maturation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
embryonic organ development	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
hair follicle maturation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
hematopoietic stem cell differentiation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
hematopoietic stem cell proliferation	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
regulation of mitotic cell cycle phase transition	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
positive regulation of mitotic recombination	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
double-strand break repair	Casein kinase II subunit alpha'	Homo sapiens (human)
apoptotic process	Casein kinase II subunit alpha'	Homo sapiens (human)
spermatogenesis	Casein kinase II subunit alpha'	Homo sapiens (human)
Wnt signaling pathway	Casein kinase II subunit alpha'	Homo sapiens (human)
cerebral cortex development	Casein kinase II subunit alpha'	Homo sapiens (human)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Casein kinase II subunit alpha'	Homo sapiens (human)
liver regeneration	Casein kinase II subunit alpha'	Homo sapiens (human)
regulation of mitophagy	Casein kinase II subunit alpha'	Homo sapiens (human)
positive regulation of protein targeting to mitochondrion	Casein kinase II subunit alpha'	Homo sapiens (human)
regulation of chromosome separation	Casein kinase II subunit alpha'	Homo sapiens (human)
negative regulation of apoptotic signaling pathway	Casein kinase II subunit alpha'	Homo sapiens (human)
peptidyl-threonine phosphorylation	Casein kinase II subunit alpha'	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase II subunit alpha'	Homo sapiens (human)
peptidyl-cysteine methylation	Ras-related protein Rab-6A	Homo sapiens (human)
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	Ras-related protein Rab-6A	Homo sapiens (human)
antigen processing and presentation	Ras-related protein Rab-6A	Homo sapiens (human)
neuron projection development	Ras-related protein Rab-6A	Homo sapiens (human)
protein localization to Golgi apparatus	Ras-related protein Rab-6A	Homo sapiens (human)
early endosome to Golgi transport	Ras-related protein Rab-6A	Homo sapiens (human)
minus-end-directed organelle transport along microtubule	Ras-related protein Rab-6A	Homo sapiens (human)
protein localization to Golgi membrane	Ras-related protein Rab-6A	Homo sapiens (human)
intracellular protein transport	Ras-related protein Rab-6A	Homo sapiens (human)
intra-Golgi vesicle-mediated transport	Ras-related protein Rab-6A	Homo sapiens (human)
retrograde transport, endosome to Golgi	Ras-related protein Rab-6A	Homo sapiens (human)
positive regulation of cell-matrix adhesion	Ephrin type-A receptor 1	Homo sapiens (human)
negative regulation of protein kinase activity	Ephrin type-A receptor 1	Homo sapiens (human)
cell surface receptor signaling pathway	Ephrin type-A receptor 1	Homo sapiens (human)
positive regulation of cell population proliferation	Ephrin type-A receptor 1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Ephrin type-A receptor 1	Homo sapiens (human)
positive regulation of cell migration	Ephrin type-A receptor 1	Homo sapiens (human)
negative regulation of cell migration	Ephrin type-A receptor 1	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Ephrin type-A receptor 1	Homo sapiens (human)
regulation of GTPase activity	Ephrin type-A receptor 1	Homo sapiens (human)
positive regulation of angiogenesis	Ephrin type-A receptor 1	Homo sapiens (human)
protein autophosphorylation	Ephrin type-A receptor 1	Homo sapiens (human)
positive regulation of stress fiber assembly	Ephrin type-A receptor 1	Homo sapiens (human)
activation of GTPase activity	Ephrin type-A receptor 1	Homo sapiens (human)
positive regulation of kinase activity	Ephrin type-A receptor 1	Homo sapiens (human)
multicellular organism development	Ephrin type-A receptor 1	Homo sapiens (human)
angiogenesis	Ephrin type-A receptor 1	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-A receptor 1	Homo sapiens (human)
endocardial cushion development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of cell adhesion	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
signal transduction	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
peripheral nervous system development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
heart development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of signal transduction	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of gene expression	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
Schwann cell differentiation	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
Schwann cell development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
cranial nerve development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
wound healing	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
regulation of cell population proliferation	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
myelination	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of neuron apoptotic process	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of secretion	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
neuron apoptotic process	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of cardiac muscle tissue development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of calcineurin-NFAT signaling cascade	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
motor neuron apoptotic process	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of motor neuron apoptotic process	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
negative regulation of apoptotic process	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
neurogenesis	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of cell population proliferation	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
positive regulation of kinase activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
multicellular organism development	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
GMP biosynthetic process	Multifunctional protein ADE2	Homo sapiens (human)
'de novo' IMP biosynthetic process	Multifunctional protein ADE2	Homo sapiens (human)
purine nucleobase biosynthetic process	Multifunctional protein ADE2	Homo sapiens (human)
'de novo' AMP biosynthetic process	Multifunctional protein ADE2	Homo sapiens (human)
'de novo' XMP biosynthetic process	Multifunctional protein ADE2	Homo sapiens (human)
GTP biosynthetic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
UTP biosynthetic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
CTP biosynthetic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
cell adhesion	Nucleoside diphosphate kinase B	Homo sapiens (human)
integrin-mediated signaling pathway	Nucleoside diphosphate kinase B	Homo sapiens (human)
nucleoside triphosphate biosynthetic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
negative regulation of apoptotic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
positive regulation of keratinocyte differentiation	Nucleoside diphosphate kinase B	Homo sapiens (human)
regulation of epidermis development	Nucleoside diphosphate kinase B	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nucleoside diphosphate kinase B	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nucleoside diphosphate kinase B	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Nucleoside diphosphate kinase B	Homo sapiens (human)
regulation of apoptotic process	Nucleoside diphosphate kinase B	Homo sapiens (human)
renal water homeostasis	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
spermatogenesis	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
male gonad development	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
high-density lipoprotein particle assembly	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
protein kinase A signaling	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
neural tube closure	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
renal water homeostasis	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
protein phosphorylation	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
signal transduction	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
high-density lipoprotein particle assembly	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
negative regulation of smoothened signaling pathway	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
regulation of protein processing	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
negative regulation of TORC1 signaling	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
protein kinase A signaling	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
generation of precursor metabolites and energy	Ferrochelatase, mitochondrial	Homo sapiens (human)
heme biosynthetic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
heme A biosynthetic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
heme B biosynthetic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
cholesterol metabolic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to xenobiotic stimulus	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to light stimulus	Ferrochelatase, mitochondrial	Homo sapiens (human)
detection of UV	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to lead ion	Ferrochelatase, mitochondrial	Homo sapiens (human)
regulation of eIF2 alpha phosphorylation by heme	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to insecticide	Ferrochelatase, mitochondrial	Homo sapiens (human)
erythrocyte differentiation	Ferrochelatase, mitochondrial	Homo sapiens (human)
very-low-density lipoprotein particle assembly	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to ethanol	Ferrochelatase, mitochondrial	Homo sapiens (human)
protoporphyrinogen IX metabolic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to arsenic-containing substance	Ferrochelatase, mitochondrial	Homo sapiens (human)
regulation of hemoglobin biosynthetic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
heme O biosynthetic process	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to methylmercury	Ferrochelatase, mitochondrial	Homo sapiens (human)
multicellular organismal-level iron ion homeostasis	Ferrochelatase, mitochondrial	Homo sapiens (human)
response to platinum ion	Ferrochelatase, mitochondrial	Homo sapiens (human)
cellular response to dexamethasone stimulus	Ferrochelatase, mitochondrial	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
behavioral fear response	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
skeletal muscle contraction	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
apoptotic process	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
signal transduction	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
germ cell development	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
long-term memory	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to xenobiotic stimulus	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to mechanical stimulus	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to toxic substance	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to glucose	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
skeletal muscle atrophy	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to electrical stimulus involved in regulation of muscle adaptation	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of smooth muscle cell migration	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cell migration	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to nutrient levels	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cellular response to nutrient	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
TOR signaling	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to lipopolysaccharide	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to testosterone	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to glucagon	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to tumor necrosis factor	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
negative regulation of apoptotic process	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to L-leucine	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
long-chain fatty acid import into cell	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to ethanol	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of translation	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of mitotic cell cycle	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of translational initiation	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
regulation of glucose import	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
phosphatidylinositol-mediated signaling	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of skeletal muscle tissue growth	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
modulation of chemical synaptic transmission	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cellular response to type II interferon	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cellular response to growth factor stimulus	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cellular response to dexamethasone stimulus	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
positive regulation of TORC1 signaling	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cellular response to insulin stimulus	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
response to antibiotic	Tyrosine-protein kinase JAK1	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytokine-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
positive regulation of homotypic cell-cell adhesion	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-15-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-4-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-2-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-9-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-11-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
type III interferon-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
type II interferon-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
type I interferon-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-6-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
T-helper 17 cell lineage commitment	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cellular response to virus	Tyrosine-protein kinase JAK1	Homo sapiens (human)
interleukin-10-mediated signaling pathway	Tyrosine-protein kinase JAK1	Homo sapiens (human)
protein localization to cell-cell junction	Tyrosine-protein kinase JAK1	Homo sapiens (human)
positive regulation of protein localization to nucleus	Tyrosine-protein kinase JAK1	Homo sapiens (human)
positive regulation of sprouting angiogenesis	Tyrosine-protein kinase JAK1	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase JAK1	Homo sapiens (human)
tyrosine phosphorylation of STAT protein	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase JAK1	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Tyrosine-protein kinase JAK1	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 2	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 2	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 2	Homo sapiens (human)
DNA replication	Cyclin-dependent kinase 2	Homo sapiens (human)
DNA repair	Cyclin-dependent kinase 2	Homo sapiens (human)
chromatin remodeling	Cyclin-dependent kinase 2	Homo sapiens (human)
DNA-templated transcription	Cyclin-dependent kinase 2	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 2	Homo sapiens (human)
potassium ion transport	Cyclin-dependent kinase 2	Homo sapiens (human)
centriole replication	Cyclin-dependent kinase 2	Homo sapiens (human)
Ras protein signal transduction	Cyclin-dependent kinase 2	Homo sapiens (human)
regulation of mitotic cell cycle	Cyclin-dependent kinase 2	Homo sapiens (human)
positive regulation of cell population proliferation	Cyclin-dependent kinase 2	Homo sapiens (human)
peptidyl-serine phosphorylation	Cyclin-dependent kinase 2	Homo sapiens (human)
positive regulation of heterochromatin formation	Cyclin-dependent kinase 2	Homo sapiens (human)
mitotic G1 DNA damage checkpoint signaling	Cyclin-dependent kinase 2	Homo sapiens (human)
positive regulation of DNA-templated DNA replication initiation	Cyclin-dependent kinase 2	Homo sapiens (human)
telomere maintenance in response to DNA damage	Cyclin-dependent kinase 2	Homo sapiens (human)
post-translational protein modification	Cyclin-dependent kinase 2	Homo sapiens (human)
positive regulation of DNA replication	Cyclin-dependent kinase 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Cyclin-dependent kinase 2	Homo sapiens (human)
centrosome duplication	Cyclin-dependent kinase 2	Homo sapiens (human)
cell division	Cyclin-dependent kinase 2	Homo sapiens (human)
meiotic cell cycle	Cyclin-dependent kinase 2	Homo sapiens (human)
cellular response to nitric oxide	Cyclin-dependent kinase 2	Homo sapiens (human)
cellular senescence	Cyclin-dependent kinase 2	Homo sapiens (human)
regulation of anaphase-promoting complex-dependent catabolic process	Cyclin-dependent kinase 2	Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 2	Homo sapiens (human)
signal transduction	Cyclin-dependent kinase 2	Homo sapiens (human)
regulation of gene expression	Cyclin-dependent kinase 2	Homo sapiens (human)
response to organic substance	Cyclin-dependent kinase 2	Homo sapiens (human)
desensitization of G protein-coupled receptor signaling pathway	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
negative regulation of the force of heart contraction by chemical signal	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
G protein-coupled acetylcholine receptor signaling pathway	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
tachykinin receptor signaling pathway	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
heart development	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
viral genome replication	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
receptor internalization	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
positive regulation of catecholamine secretion	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
negative regulation of striated muscle contraction	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
symbiont entry into host cell	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
cardiac muscle contraction	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
negative regulation of relaxation of smooth muscle	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
regulation of the force of heart contraction	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
protein phosphorylation	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
P-body assembly	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
miRNA-mediated gene silencing by inhibition of translation	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
negative regulation of translation	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
viral RNA genome packaging	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
stem cell population maintenance	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
neuron differentiation	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
P-body assembly	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
negative regulation of neuron differentiation	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
stress granule assembly	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
positive regulation of macrophage chemotaxis	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of macrophage proliferation	Mitogen-activated protein kinase 3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
DNA-templated transcription	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
apoptotic process	Mitogen-activated protein kinase 3	Homo sapiens (human)
insulin receptor signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
Schwann cell development	Mitogen-activated protein kinase 3	Homo sapiens (human)
phosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
sensory perception of pain	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of ossification	Mitogen-activated protein kinase 3	Homo sapiens (human)
BMP signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of cellular pH	Mitogen-activated protein kinase 3	Homo sapiens (human)
thyroid gland development	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of cyclase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of stress-activated MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 3	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Mitogen-activated protein kinase 3	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
outer ear morphogenesis	Mitogen-activated protein kinase 3	Homo sapiens (human)
myelination	Mitogen-activated protein kinase 3	Homo sapiens (human)
signal transduction in response to DNA damage	Mitogen-activated protein kinase 3	Homo sapiens (human)
response to exogenous dsRNA	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 3	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
thymus development	Mitogen-activated protein kinase 3	Homo sapiens (human)
modulation of chemical synaptic transmission	Mitogen-activated protein kinase 3	Homo sapiens (human)
cartilage development	Mitogen-activated protein kinase 3	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of cytoskeleton organization	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomerase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
Bergmann glial cell differentiation	Mitogen-activated protein kinase 3	Homo sapiens (human)
face development	Mitogen-activated protein kinase 3	Homo sapiens (human)
lung morphogenesis	Mitogen-activated protein kinase 3	Homo sapiens (human)
trachea formation	Mitogen-activated protein kinase 3	Homo sapiens (human)
cardiac neural crest cell development involved in heart development	Mitogen-activated protein kinase 3	Homo sapiens (human)
ERK1 and ERK2 cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Mitogen-activated protein kinase 3	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Mitogen-activated protein kinase 3	Homo sapiens (human)
response to epidermal growth factor	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 3	Homo sapiens (human)
cellular response to tumor necrosis factor	Mitogen-activated protein kinase 3	Homo sapiens (human)
caveolin-mediated endocytosis	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of Golgi inheritance	Mitogen-activated protein kinase 3	Homo sapiens (human)
xenophagy	Mitogen-activated protein kinase 3	Homo sapiens (human)
negative regulation of TORC1 signaling	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of telomere capping	Mitogen-activated protein kinase 3	Homo sapiens (human)
positive regulation of xenophagy	Mitogen-activated protein kinase 3	Homo sapiens (human)
regulation of early endosome to late endosome transport	Mitogen-activated protein kinase 3	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein phosphorylation	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
peptidyl-serine phosphorylation	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
positive regulation of protein binding	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
negative regulation of hippo signaling	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
peptidyl-serine autophosphorylation	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
negative regulation of protein localization to nucleus	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
intracellular signal transduction	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
pyrimidine nucleotide metabolic process	Deoxycytidine kinase	Homo sapiens (human)
CMP biosynthetic process	Deoxycytidine kinase	Homo sapiens (human)
dAMP salvage	Deoxycytidine kinase	Homo sapiens (human)
nucleoside phosphate biosynthetic process	Deoxycytidine kinase	Homo sapiens (human)
positive regulation of macrophage chemotaxis	Mitogen-activated protein kinase 1	Homo sapiens (human)
positive regulation of macrophage proliferation	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 1	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 1	Homo sapiens (human)
apoptotic process	Mitogen-activated protein kinase 1	Homo sapiens (human)
chemotaxis	Mitogen-activated protein kinase 1	Homo sapiens (human)
DNA damage response	Mitogen-activated protein kinase 1	Homo sapiens (human)
signal transduction	Mitogen-activated protein kinase 1	Homo sapiens (human)
chemical synaptic transmission	Mitogen-activated protein kinase 1	Homo sapiens (human)
learning or memory	Mitogen-activated protein kinase 1	Homo sapiens (human)
insulin receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Mitogen-activated protein kinase 1	Homo sapiens (human)
Schwann cell development	Mitogen-activated protein kinase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase 1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Mitogen-activated protein kinase 1	Homo sapiens (human)
cytosine metabolic process	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of ossification	Mitogen-activated protein kinase 1	Homo sapiens (human)
androgen receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of cellular pH	Mitogen-activated protein kinase 1	Homo sapiens (human)
thyroid gland development	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of protein stability	Mitogen-activated protein kinase 1	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of stress-activated MAPK cascade	Mitogen-activated protein kinase 1	Homo sapiens (human)
mammary gland epithelial cell proliferation	Mitogen-activated protein kinase 1	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase 1	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 1	Homo sapiens (human)
response to nicotine	Mitogen-activated protein kinase 1	Homo sapiens (human)
ERBB signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
outer ear morphogenesis	Mitogen-activated protein kinase 1	Homo sapiens (human)
myelination	Mitogen-activated protein kinase 1	Homo sapiens (human)
response to exogenous dsRNA	Mitogen-activated protein kinase 1	Homo sapiens (human)
steroid hormone mediated signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
negative regulation of cell differentiation	Mitogen-activated protein kinase 1	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
thymus development	Mitogen-activated protein kinase 1	Homo sapiens (human)
progesterone receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
T cell receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
B cell receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of cytoskeleton organization	Mitogen-activated protein kinase 1	Homo sapiens (human)
positive regulation of telomerase activity	Mitogen-activated protein kinase 1	Homo sapiens (human)
Bergmann glial cell differentiation	Mitogen-activated protein kinase 1	Homo sapiens (human)
long-term synaptic potentiation	Mitogen-activated protein kinase 1	Homo sapiens (human)
face development	Mitogen-activated protein kinase 1	Homo sapiens (human)
lung morphogenesis	Mitogen-activated protein kinase 1	Homo sapiens (human)
trachea formation	Mitogen-activated protein kinase 1	Homo sapiens (human)
labyrinthine layer blood vessel development	Mitogen-activated protein kinase 1	Homo sapiens (human)
cardiac neural crest cell development involved in heart development	Mitogen-activated protein kinase 1	Homo sapiens (human)
ERK1 and ERK2 cascade	Mitogen-activated protein kinase 1	Homo sapiens (human)
response to epidermal growth factor	Mitogen-activated protein kinase 1	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 1	Homo sapiens (human)
cellular response to tumor necrosis factor	Mitogen-activated protein kinase 1	Homo sapiens (human)
caveolin-mediated endocytosis	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of Golgi inheritance	Mitogen-activated protein kinase 1	Homo sapiens (human)
positive regulation of telomere capping	Mitogen-activated protein kinase 1	Homo sapiens (human)
regulation of early endosome to late endosome transport	Mitogen-activated protein kinase 1	Homo sapiens (human)
cell surface receptor signaling pathway	Mitogen-activated protein kinase 1	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 1	Homo sapiens (human)
skeletal system development	Ephrin type-A receptor 2	Homo sapiens (human)
vasculogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
osteoblast differentiation	Ephrin type-A receptor 2	Homo sapiens (human)
blood vessel endothelial cell proliferation involved in sprouting angiogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
inflammatory response	Ephrin type-A receptor 2	Homo sapiens (human)
cell adhesion	Ephrin type-A receptor 2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Ephrin type-A receptor 2	Homo sapiens (human)
regulation of lamellipodium assembly	Ephrin type-A receptor 2	Homo sapiens (human)
notochord formation	Ephrin type-A receptor 2	Homo sapiens (human)
cell migration	Ephrin type-A receptor 2	Homo sapiens (human)
negative regulation of angiogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
neural tube development	Ephrin type-A receptor 2	Homo sapiens (human)
neuron differentiation	Ephrin type-A receptor 2	Homo sapiens (human)
keratinocyte differentiation	Ephrin type-A receptor 2	Homo sapiens (human)
osteoclast differentiation	Ephrin type-A receptor 2	Homo sapiens (human)
positive regulation of cell migration	Ephrin type-A receptor 2	Homo sapiens (human)
negative regulation of chemokine production	Ephrin type-A receptor 2	Homo sapiens (human)
mammary gland epithelial cell proliferation	Ephrin type-A receptor 2	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Ephrin type-A receptor 2	Homo sapiens (human)
post-anal tail morphogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
regulation of blood vessel endothelial cell migration	Ephrin type-A receptor 2	Homo sapiens (human)
regulation of angiogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
cAMP metabolic process	Ephrin type-A receptor 2	Homo sapiens (human)
symbiont entry into host cell	Ephrin type-A receptor 2	Homo sapiens (human)
bone remodeling	Ephrin type-A receptor 2	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-A receptor 2	Homo sapiens (human)
axial mesoderm formation	Ephrin type-A receptor 2	Homo sapiens (human)
cell motility	Ephrin type-A receptor 2	Homo sapiens (human)
defense response to Gram-positive bacterium	Ephrin type-A receptor 2	Homo sapiens (human)
notochord cell development	Ephrin type-A receptor 2	Homo sapiens (human)
cell chemotaxis	Ephrin type-A receptor 2	Homo sapiens (human)
branching involved in mammary gland duct morphogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
lens fiber cell morphogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Ephrin type-A receptor 2	Homo sapiens (human)
response to growth factor	Ephrin type-A receptor 2	Homo sapiens (human)
protein localization to plasma membrane	Ephrin type-A receptor 2	Homo sapiens (human)
activation of GTPase activity	Ephrin type-A receptor 2	Homo sapiens (human)
negative regulation of lymphangiogenesis	Ephrin type-A receptor 2	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Ephrin type-A receptor 2	Homo sapiens (human)
positive regulation of bicellular tight junction assembly	Ephrin type-A receptor 2	Homo sapiens (human)
pericyte cell differentiation	Ephrin type-A receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Ephrin type-A receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Ephrin type-A receptor 2	Homo sapiens (human)
multicellular organism development	Ephrin type-A receptor 2	Homo sapiens (human)
negative regulation of protein kinase activity	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of autophagosome assembly	Ephrin type-B receptor 2	Homo sapiens (human)
angiogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
urogenital system development	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of protein phosphorylation	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of immunoglobulin production	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of cell adhesion	Ephrin type-B receptor 2	Homo sapiens (human)
nervous system development	Ephrin type-B receptor 2	Homo sapiens (human)
axon guidance	Ephrin type-B receptor 2	Homo sapiens (human)
axonal fasciculation	Ephrin type-B receptor 2	Homo sapiens (human)
learning or memory	Ephrin type-B receptor 2	Homo sapiens (human)
learning	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of gene expression	Ephrin type-B receptor 2	Homo sapiens (human)
phosphorylation	Ephrin type-B receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Ephrin type-B receptor 2	Homo sapiens (human)
optic nerve morphogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
hindbrain tangential cell migration	Ephrin type-B receptor 2	Homo sapiens (human)
central nervous system projection neuron axonogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
corpus callosum development	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of blood coagulation	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of cell migration	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of B cell proliferation	Ephrin type-B receptor 2	Homo sapiens (human)
retinal ganglion cell axon guidance	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of synaptic plasticity	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Ephrin type-B receptor 2	Homo sapiens (human)
B cell activation	Ephrin type-B receptor 2	Homo sapiens (human)
inner ear morphogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of receptor signaling pathway via JAK-STAT	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of Ras protein signal transduction	Ephrin type-B receptor 2	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of neuronal synaptic plasticity	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of long-term neuronal synaptic plasticity	Ephrin type-B receptor 2	Homo sapiens (human)
camera-type eye morphogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of axonogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of body fluid levels	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of filopodium assembly	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of synapse assembly	Ephrin type-B receptor 2	Homo sapiens (human)
roof of mouth development	Ephrin type-B receptor 2	Homo sapiens (human)
dendritic spine development	Ephrin type-B receptor 2	Homo sapiens (human)
dendritic spine morphogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of dendritic spine morphogenesis	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Ephrin type-B receptor 2	Homo sapiens (human)
cellular response to lipopolysaccharide	Ephrin type-B receptor 2	Homo sapiens (human)
commissural neuron axon guidance	Ephrin type-B receptor 2	Homo sapiens (human)
postsynaptic membrane assembly	Ephrin type-B receptor 2	Homo sapiens (human)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	Ephrin type-B receptor 2	Homo sapiens (human)
neuron projection retraction	Ephrin type-B receptor 2	Homo sapiens (human)
vesicle-mediated intercellular transport	Ephrin type-B receptor 2	Homo sapiens (human)
tight junction assembly	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of cytokine production involved in inflammatory response	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Ephrin type-B receptor 2	Homo sapiens (human)
cellular response to amyloid-beta	Ephrin type-B receptor 2	Homo sapiens (human)
negative regulation of NMDA glutamate receptor activity	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of NMDA glutamate receptor activity	Ephrin type-B receptor 2	Homo sapiens (human)
positive regulation of protein localization to cell surface	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of T-helper 17 type immune response	Ephrin type-B receptor 2	Homo sapiens (human)
regulation of behavioral fear response	Ephrin type-B receptor 2	Homo sapiens (human)
protein phosphorylation	Ephrin type-B receptor 2	Homo sapiens (human)
protein phosphorylation	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
immune response	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytokine-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of type II interferon production	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of interleukin-17 production	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of natural killer cell proliferation	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
interleukin-12-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
type III interferon-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of T cell proliferation	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of NK T cell proliferation	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
type II interferon-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
type I interferon-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cellular response to virus	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
interleukin-10-mediated signaling pathway	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of protein localization to nucleus	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
positive regulation of T-helper 17 type immune response	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
intracellular signal transduction	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cell differentiation	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic process	UMP-CMP kinase	Homo sapiens (human)
UMP biosynthetic process	UMP-CMP kinase	Homo sapiens (human)
UDP biosynthetic process	UMP-CMP kinase	Homo sapiens (human)
pyrimidine ribonucleotide biosynthetic process	UMP-CMP kinase	Homo sapiens (human)
nucleobase-containing small molecule interconversion	UMP-CMP kinase	Homo sapiens (human)
nucleoside monophosphate phosphorylation	UMP-CMP kinase	Homo sapiens (human)
CDP biosynthetic process	UMP-CMP kinase	Homo sapiens (human)
negative regulation of MAPK cascade	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Wee1-like protein kinase	Homo sapiens (human)
microtubule cytoskeleton organization	Wee1-like protein kinase	Homo sapiens (human)
negative regulation of G2/M transition of mitotic cell cycle	Wee1-like protein kinase	Homo sapiens (human)
establishment of cell polarity	Wee1-like protein kinase	Homo sapiens (human)
positive regulation of DNA replication	Wee1-like protein kinase	Homo sapiens (human)
neuron projection morphogenesis	Wee1-like protein kinase	Homo sapiens (human)
cell division	Wee1-like protein kinase	Homo sapiens (human)
negative regulation of G1/S transition of mitotic cell cycle	Wee1-like protein kinase	Homo sapiens (human)
protein phosphorylation	Wee1-like protein kinase	Homo sapiens (human)
response to hypoxia	Heme oxygenase 2	Homo sapiens (human)
response to oxidative stress	Heme oxygenase 2	Homo sapiens (human)
heme catabolic process	Heme oxygenase 2	Homo sapiens (human)
heme oxidation	Heme oxygenase 2	Homo sapiens (human)
S-adenosylmethionine biosynthetic process	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
one-carbon metabolic process	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
protein hexamerization	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
protein heterooligomerization	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
cellular response to methionine	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
positive regulation of TORC1 signaling	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
cellular response to leukemia inhibitory factor	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
protein folding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
response to unfolded protein	DnaJ homolog subfamily A member 1	Homo sapiens (human)
spermatogenesis	DnaJ homolog subfamily A member 1	Homo sapiens (human)
response to heat	DnaJ homolog subfamily A member 1	Homo sapiens (human)
flagellated sperm motility	DnaJ homolog subfamily A member 1	Homo sapiens (human)
androgen receptor signaling pathway	DnaJ homolog subfamily A member 1	Homo sapiens (human)
negative regulation of protein ubiquitination	DnaJ homolog subfamily A member 1	Homo sapiens (human)
positive regulation of apoptotic process	DnaJ homolog subfamily A member 1	Homo sapiens (human)
negative regulation of apoptotic process	DnaJ homolog subfamily A member 1	Homo sapiens (human)
negative regulation of JUN kinase activity	DnaJ homolog subfamily A member 1	Homo sapiens (human)
regulation of protein transport	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein localization to mitochondrion	DnaJ homolog subfamily A member 1	Homo sapiens (human)
negative regulation of establishment of protein localization to mitochondrion	DnaJ homolog subfamily A member 1	Homo sapiens (human)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein refolding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
activation-induced cell death of T cells	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
osteoblast differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
maternal placenta development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endothelial cell proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
sphingosine-1-phosphate receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glucose metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of translation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein import into nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nitric oxide biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
inflammatory response	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to oxidative stress	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
G protein-coupled receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
canonical NF-kappaB signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell population proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
insulin receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
apoptotic mitochondrial changes	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to heat	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of autophagy	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endothelial cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of gene expression	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of long-chain fatty acid import across plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
fibroblast migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fibroblast migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of sodium ion transport	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of endopeptidase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of neuron projection development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of macroautophagy	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein ubiquitination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-serine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-threonine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
virus-mediated perturbation of host defense response	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytokine-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mammalian oogenesis stage	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell growth	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
T cell costimulation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein ubiquitination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of myelination	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
TOR signaling	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of fatty acid beta-oxidation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endodeoxyribonuclease activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to food	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
peripheral nervous system myelin maintenance	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to insulin stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to fluid shear stress	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to reactive oxygen species	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
interleukin-18-mediated signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to decreased oxygen levels	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glucose homeostasis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
anoikis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of mRNA stability	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fat cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glycogen biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cyclin-dependent protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of Notch signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of proteolysis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of DNA-templated transcription	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose import	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of organ growth	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein autophosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of lipid biosynthetic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
behavioral response to pain	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of nitric-oxide synthase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
striated muscle cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein metabolic process	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
excitatory postsynaptic potential	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to growth hormone	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mammary gland epithelial cell differentiation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
labyrinthine layer blood vessel development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to UV-A	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to growth factor	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to cadmium ion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to tumor necrosis factor	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to prostaglandin E stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
establishment of protein localization to mitochondrion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
maintenance of protein location in mitochondrion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of release of cytochrome c from mitochondria	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to granulocyte macrophage colony-stimulating factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
execution phase of apoptosis	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of postsynapse organization	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of tRNA methylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to oxidised low-density lipoprotein particle stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of protein localization to lysosome	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cGAS/STING signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to peptide	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cilium assembly	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of leukocyte cell-cell adhesion	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of I-kappaB phosphorylation	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of TORC1 signaling	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to endoplasmic reticulum	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cellular response to nerve growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
response to insulin-like growth factor stimulus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein localization to cell surface	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
regulation of type B pancreatic cell development	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of lymphocyte migration	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glycogen biosynthetic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
glucose metabolic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of translation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
signal transduction	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
insulin receptor signaling pathway	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of long-chain fatty acid import across plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose metabolic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell migration	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell migration	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of fatty acid beta-oxidation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
peripheral nervous system myelin maintenance	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cellular response to insulin stimulus	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein modification process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
fat cell differentiation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glycogen biosynthetic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of glucose import	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell cycle	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
mammary gland epithelial cell differentiation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cellular response to high light intensity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
organic substance transport	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein localization to plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of protein targeting to membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
retinal rod cell apoptotic process	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell motility	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-serine phosphorylation	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
DNA replication	DNA replication licensing factor MCM4	Homo sapiens (human)
DNA unwinding involved in DNA replication	DNA replication licensing factor MCM4	Homo sapiens (human)
regulation of DNA-templated DNA replication initiation	DNA replication licensing factor MCM4	Homo sapiens (human)
double-strand break repair via break-induced replication	DNA replication licensing factor MCM4	Homo sapiens (human)
DNA strand elongation involved in DNA replication	DNA replication licensing factor MCM4	Homo sapiens (human)
mitotic DNA replication initiation	DNA replication licensing factor MCM4	Homo sapiens (human)
mitotic cytokinesis	Myosin-10	Homo sapiens (human)
actin filament-based movement	Myosin-10	Homo sapiens (human)
cell adhesion	Myosin-10	Homo sapiens (human)
actomyosin structure organization	Myosin-10	Homo sapiens (human)
positive regulation of protein secretion	Myosin-10	Homo sapiens (human)
mitotic cytokinesis	Myosin-10	Homo sapiens (human)
regulation of cell shape	Myosin-10	Homo sapiens (human)
heart development	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
positive regulation of gene expression	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
Schwann cell development	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
thyroid gland development	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
regulation of stress-activated MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
peptidyl-serine autophosphorylation	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
myelination	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
thymus development	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
regulation of axon regeneration	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
positive regulation of axonogenesis	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
face development	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
trachea formation	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
epithelial cell proliferation involved in lung morphogenesis	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
ERK1 and ERK2 cascade	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
positive regulation of protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
regulation of Golgi inheritance	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
positive regulation of cell motility	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
regulation of early endosome to late endosome transport	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
hemopoiesis	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
leukocyte homeostasis	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
myeloid progenitor cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
pro-B cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of cell population proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
response to organonitrogen compound	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cytokine-mediated signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
B cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
animal organ regeneration	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
common myeloid progenitor cell proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
regulation of apoptotic process	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of MAP kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of MAPK cascade	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
lymphocyte proliferation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein autophosphorylation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cellular response to cytokine stimulus	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cellular response to glucocorticoid stimulus	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
dendritic cell differentiation	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
positive regulation of kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
multicellular organism development	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
regulation of cardiac muscle cell apoptotic process	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
regulation of neural crest cell differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of gene expression	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
negative regulation of gene expression	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of transforming growth factor beta2 production	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
angiogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
osteoblast differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
in utero embryonic development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
mesoderm formation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
somitogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
Mullerian duct regression	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of mesenchymal cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
chondrocyte differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
outflow tract septum morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
outflow tract morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
cardiac conduction system development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
atrioventricular valve development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
mitral valve morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
tricuspid valve morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
endocardial cushion morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
cardiac right ventricle morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
ventricular trabecula myocardium morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
ventricular compact myocardium morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
endocardial cushion formation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
immune response	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
ectoderm development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
dorsal/ventral axis specification	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
neural crest cell development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
negative regulation of smooth muscle cell migration	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
central nervous system neuron differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
pituitary gland development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
neural plate mediolateral regionalization	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
lung development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of bone mineralization	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
BMP signaling pathway	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
somatic stem cell population maintenance	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
hindlimb morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
dorsal aorta morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
embryonic digit morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of osteoblast differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
paraxial mesoderm structural organization	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
lateral mesoderm development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
regulation of lateral mesodermal cell fate specification	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
mesendoderm development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
embryonic organ development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
developmental growth	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
epithelial cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
negative regulation of neurogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
negative regulation of muscle cell differentiation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
roof of mouth development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
regulation of cardiac muscle cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of SMAD protein signal transduction	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
ventricular septum morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
heart formation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
atrioventricular node cell development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
pharyngeal arch artery morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
cellular response to BMP stimulus	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of miRNA transcription	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of cardiac ventricle development	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
fibrous ring of heart morphogenesis	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
regulation of cellular senescence	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
protein phosphorylation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
dorsal/ventral pattern formation	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
cellular response to growth factor stimulus	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Activin receptor type-1B	Homo sapiens (human)
in utero embryonic development	Activin receptor type-1B	Homo sapiens (human)
hair follicle development	Activin receptor type-1B	Homo sapiens (human)
regulation of DNA-templated transcription	Activin receptor type-1B	Homo sapiens (human)
signal transduction	Activin receptor type-1B	Homo sapiens (human)
cell surface receptor protein serine/threonine kinase signaling pathway	Activin receptor type-1B	Homo sapiens (human)
positive regulation of gene expression	Activin receptor type-1B	Homo sapiens (human)
negative regulation of gene expression	Activin receptor type-1B	Homo sapiens (human)
peptidyl-threonine phosphorylation	Activin receptor type-1B	Homo sapiens (human)
negative regulation of cell growth	Activin receptor type-1B	Homo sapiens (human)
activin receptor signaling pathway	Activin receptor type-1B	Homo sapiens (human)
positive regulation of activin receptor signaling pathway	Activin receptor type-1B	Homo sapiens (human)
nodal signaling pathway	Activin receptor type-1B	Homo sapiens (human)
positive regulation of erythrocyte differentiation	Activin receptor type-1B	Homo sapiens (human)
protein autophosphorylation	Activin receptor type-1B	Homo sapiens (human)
extrinsic apoptotic signaling pathway	Activin receptor type-1B	Homo sapiens (human)
positive regulation of trophoblast cell migration	Activin receptor type-1B	Homo sapiens (human)
cellular response to growth factor stimulus	Activin receptor type-1B	Homo sapiens (human)
protein phosphorylation	Activin receptor type-1B	Homo sapiens (human)
nervous system development	Activin receptor type-1B	Homo sapiens (human)
proepicardium development	TGF-beta receptor type-1	Homo sapiens (human)
negative regulation of cell migration	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of extracellular matrix assembly	TGF-beta receptor type-1	Homo sapiens (human)
skeletal system development	TGF-beta receptor type-1	Homo sapiens (human)
in utero embryonic development	TGF-beta receptor type-1	Homo sapiens (human)
kidney development	TGF-beta receptor type-1	Homo sapiens (human)
blastocyst development	TGF-beta receptor type-1	Homo sapiens (human)
epithelial to mesenchymal transition	TGF-beta receptor type-1	Homo sapiens (human)
endothelial cell proliferation	TGF-beta receptor type-1	Homo sapiens (human)
negative regulation of endothelial cell proliferation	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of endothelial cell proliferation	TGF-beta receptor type-1	Homo sapiens (human)
lens development in camera-type eye	TGF-beta receptor type-1	Homo sapiens (human)
ventricular trabecula myocardium morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
ventricular compact myocardium morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
regulation of DNA-templated transcription	TGF-beta receptor type-1	Homo sapiens (human)
apoptotic process	TGF-beta receptor type-1	Homo sapiens (human)
signal transduction	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	TGF-beta receptor type-1	Homo sapiens (human)
heart development	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of cell population proliferation	TGF-beta receptor type-1	Homo sapiens (human)
germ cell migration	TGF-beta receptor type-1	Homo sapiens (human)
male gonad development	TGF-beta receptor type-1	Homo sapiens (human)
post-embryonic development	TGF-beta receptor type-1	Homo sapiens (human)
anterior/posterior pattern specification	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of gene expression	TGF-beta receptor type-1	Homo sapiens (human)
regulation of epithelial to mesenchymal transition	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	TGF-beta receptor type-1	Homo sapiens (human)
peptidyl-serine phosphorylation	TGF-beta receptor type-1	Homo sapiens (human)
collagen fibril organization	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of cell growth	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of cell migration	TGF-beta receptor type-1	Homo sapiens (human)
regulation of protein ubiquitination	TGF-beta receptor type-1	Homo sapiens (human)
negative regulation of chondrocyte differentiation	TGF-beta receptor type-1	Homo sapiens (human)
activin receptor signaling pathway	TGF-beta receptor type-1	Homo sapiens (human)
intracellular signal transduction	TGF-beta receptor type-1	Homo sapiens (human)
myofibroblast differentiation	TGF-beta receptor type-1	Homo sapiens (human)
wound healing	TGF-beta receptor type-1	Homo sapiens (human)
endothelial cell activation	TGF-beta receptor type-1	Homo sapiens (human)
extracellular structure organization	TGF-beta receptor type-1	Homo sapiens (human)
endothelial cell migration	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of DNA-templated transcription	TGF-beta receptor type-1	Homo sapiens (human)
filopodium assembly	TGF-beta receptor type-1	Homo sapiens (human)
thymus development	TGF-beta receptor type-1	Homo sapiens (human)
neuron fate commitment	TGF-beta receptor type-1	Homo sapiens (human)
embryonic cranial skeleton morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
skeletal system morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
mesenchymal cell differentiation	TGF-beta receptor type-1	Homo sapiens (human)
artery morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
cell motility	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of filopodium assembly	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of stress fiber assembly	TGF-beta receptor type-1	Homo sapiens (human)
regulation of cell cycle	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TGF-beta receptor type-1	Homo sapiens (human)
parathyroid gland development	TGF-beta receptor type-1	Homo sapiens (human)
roof of mouth development	TGF-beta receptor type-1	Homo sapiens (human)
pharyngeal system development	TGF-beta receptor type-1	Homo sapiens (human)
regulation of cardiac muscle cell proliferation	TGF-beta receptor type-1	Homo sapiens (human)
cardiac epithelial to mesenchymal transition	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of SMAD protein signal transduction	TGF-beta receptor type-1	Homo sapiens (human)
ventricular septum morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
angiogenesis involved in coronary vascular morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
coronary artery morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
response to cholesterol	TGF-beta receptor type-1	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of mesenchymal stem cell proliferation	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of vasculature development	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of tight junction disassembly	TGF-beta receptor type-1	Homo sapiens (human)
epicardium morphogenesis	TGF-beta receptor type-1	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	TGF-beta receptor type-1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	TGF-beta receptor type-1	Homo sapiens (human)
protein phosphorylation	TGF-beta receptor type-1	Homo sapiens (human)
cellular response to growth factor stimulus	TGF-beta receptor type-1	Homo sapiens (human)
nervous system development	TGF-beta receptor type-1	Homo sapiens (human)
amino acid catabolic process	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
respiratory electron transport chain	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
fatty acid beta-oxidation using acyl-CoA dehydrogenase	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
cell morphogenesis	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
regulation of DNA-templated transcription	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
proteolysis	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of cell population proliferation	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of signal transduction	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
regulation of gene expression	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of autophagy	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of gene expression	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
protein ubiquitination	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of transcription elongation by RNA polymerase II	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of apoptotic process	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
positive regulation of cell differentiation	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
positive regulation of DNA-templated transcription	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of receptor signaling pathway via JAK-STAT	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
protein stabilization	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
cellular response to hypoxia	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
regulation of cellular response to hypoxia	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
negative regulation of TORC1 signaling	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
amyloid fibril formation	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase CSK	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of cell population proliferation	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of low-density lipoprotein particle clearance	Tyrosine-protein kinase CSK	Homo sapiens (human)
T cell costimulation	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of interleukin-6 production	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of Golgi to plasma membrane protein transport	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of bone resorption	Tyrosine-protein kinase CSK	Homo sapiens (human)
oligodendrocyte differentiation	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of phagocytosis	Tyrosine-protein kinase CSK	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase CSK	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase CSK	Homo sapiens (human)
cellular response to peptide hormone stimulus	Tyrosine-protein kinase CSK	Homo sapiens (human)
regulation of Fc receptor mediated stimulatory signaling pathway	Tyrosine-protein kinase CSK	Homo sapiens (human)
adherens junction organization	Tyrosine-protein kinase CSK	Homo sapiens (human)
tRNA aminoacylation for protein translation	Glycine--tRNA ligase	Homo sapiens (human)
diadenosine tetraphosphate biosynthetic process	Glycine--tRNA ligase	Homo sapiens (human)
mitochondrial glycyl-tRNA aminoacylation	Glycine--tRNA ligase	Homo sapiens (human)
protein phosphorylation	Protein kinase C iota type	Homo sapiens (human)
protein targeting to membrane	Protein kinase C iota type	Homo sapiens (human)
cytoskeleton organization	Protein kinase C iota type	Homo sapiens (human)
actin filament organization	Protein kinase C iota type	Homo sapiens (human)
positive regulation of neuron projection development	Protein kinase C iota type	Homo sapiens (human)
vesicle-mediated transport	Protein kinase C iota type	Homo sapiens (human)
cell migration	Protein kinase C iota type	Homo sapiens (human)
cellular response to insulin stimulus	Protein kinase C iota type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C iota type	Homo sapiens (human)
establishment of apical/basal cell polarity	Protein kinase C iota type	Homo sapiens (human)
eye photoreceptor cell development	Protein kinase C iota type	Homo sapiens (human)
negative regulation of apoptotic process	Protein kinase C iota type	Homo sapiens (human)
negative regulation of neuron apoptotic process	Protein kinase C iota type	Homo sapiens (human)
establishment or maintenance of epithelial cell apical/basal polarity	Protein kinase C iota type	Homo sapiens (human)
cell-cell junction organization	Protein kinase C iota type	Homo sapiens (human)
positive regulation of Notch signaling pathway	Protein kinase C iota type	Homo sapiens (human)
positive regulation of glucose import	Protein kinase C iota type	Homo sapiens (human)
secretion	Protein kinase C iota type	Homo sapiens (human)
Golgi vesicle budding	Protein kinase C iota type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C iota type	Homo sapiens (human)
positive regulation of glial cell proliferation	Protein kinase C iota type	Homo sapiens (human)
membrane organization	Protein kinase C iota type	Homo sapiens (human)
cellular response to chemical stress	Protein kinase C iota type	Homo sapiens (human)
response to interleukin-1	Protein kinase C iota type	Homo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levels	Protein kinase C iota type	Homo sapiens (human)
positive regulation of protein localization to plasma membrane	Protein kinase C iota type	Homo sapiens (human)
positive regulation of endothelial cell apoptotic process	Protein kinase C iota type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C iota type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C iota type	Homo sapiens (human)
mRNA splicing, via spliceosome	Exosome RNA helicase MTR4	Homo sapiens (human)
maturation of 5.8S rRNA	Exosome RNA helicase MTR4	Homo sapiens (human)
rRNA processing	Exosome RNA helicase MTR4	Homo sapiens (human)
RNA catabolic process	Exosome RNA helicase MTR4	Homo sapiens (human)
DNA damage response	Exosome RNA helicase MTR4	Homo sapiens (human)
snRNA catabolic process	Exosome RNA helicase MTR4	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase Tec	Homo sapiens (human)
integrin-mediated signaling pathway	Tyrosine-protein kinase Tec	Homo sapiens (human)
regulation of platelet activation	Tyrosine-protein kinase Tec	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase Tec	Homo sapiens (human)
tissue regeneration	Tyrosine-protein kinase Tec	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase Tec	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase Tec	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase Tec	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Tyrosine-protein kinase ABL2	Homo sapiens (human)
positive regulation of phospholipase C activity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
negative regulation of Rho protein signal transduction	Tyrosine-protein kinase ABL2	Homo sapiens (human)
exploration behavior	Tyrosine-protein kinase ABL2	Homo sapiens (human)
cell adhesion	Tyrosine-protein kinase ABL2	Homo sapiens (human)
signal transduction	Tyrosine-protein kinase ABL2	Homo sapiens (human)
regulation of autophagy	Tyrosine-protein kinase ABL2	Homo sapiens (human)
positive regulation of neuron projection development	Tyrosine-protein kinase ABL2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase ABL2	Homo sapiens (human)
regulation of endocytosis	Tyrosine-protein kinase ABL2	Homo sapiens (human)
regulation of cell adhesion	Tyrosine-protein kinase ABL2	Homo sapiens (human)
regulation of actin cytoskeleton organization	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein modification process	Tyrosine-protein kinase ABL2	Homo sapiens (human)
positive regulation of oxidoreductase activity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
cellular response to retinoic acid	Tyrosine-protein kinase ABL2	Homo sapiens (human)
positive regulation of establishment of T cell polarity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
regulation of cell motility	Tyrosine-protein kinase ABL2	Homo sapiens (human)
positive regulation of T cell migration	Tyrosine-protein kinase ABL2	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase ABL2	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Tyrosine-protein kinase FRK	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase FRK	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase FRK	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase FRK	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase FRK	Homo sapiens (human)
G protein-coupled receptor signaling pathway	G protein-coupled receptor kinase 6	Homo sapiens (human)
regulation of G protein-coupled receptor signaling pathway	G protein-coupled receptor kinase 6	Homo sapiens (human)
Wnt signaling pathway	G protein-coupled receptor kinase 6	Homo sapiens (human)
regulation of signal transduction	G protein-coupled receptor kinase 6	Homo sapiens (human)
protein phosphorylation	G protein-coupled receptor kinase 6	Homo sapiens (human)
protein import into nucleus	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of DNA-binding transcription factor activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
angiogenesis	Tyrosine-protein kinase SYK	Homo sapiens (human)
cell activation	Tyrosine-protein kinase SYK	Homo sapiens (human)
lymph vessel development	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of receptor internalization	Tyrosine-protein kinase SYK	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase SYK	Homo sapiens (human)
macrophage activation involved in immune response	Tyrosine-protein kinase SYK	Homo sapiens (human)
neutrophil activation involved in immune response	Tyrosine-protein kinase SYK	Homo sapiens (human)
leukocyte activation involved in immune response	Tyrosine-protein kinase SYK	Homo sapiens (human)
serotonin secretion by platelet	Tyrosine-protein kinase SYK	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase SYK	Homo sapiens (human)
leukocyte cell-cell adhesion	Tyrosine-protein kinase SYK	Homo sapiens (human)
integrin-mediated signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
animal organ morphogenesis	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of platelet activation	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of tumor necrosis factor-mediated signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase SYK	Homo sapiens (human)
leukotriene biosynthetic process	Tyrosine-protein kinase SYK	Homo sapiens (human)
calcium-mediated signaling	Tyrosine-protein kinase SYK	Homo sapiens (human)
platelet activation	Tyrosine-protein kinase SYK	Homo sapiens (human)
B cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
neutrophil chemotaxis	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Tyrosine-protein kinase SYK	Homo sapiens (human)
receptor internalization	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of type I interferon production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of granulocyte macrophage colony-stimulating factor production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-10 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-12 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-3 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-4 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-6 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of interleukin-8 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of mast cell cytokine production	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of superoxide anion generation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of superoxide anion generation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of cell adhesion mediated by integrin	Tyrosine-protein kinase SYK	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase SYK	Homo sapiens (human)
collagen-activated tyrosine kinase receptor signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Tyrosine-protein kinase SYK	Homo sapiens (human)
interleukin-3-mediated signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
gamma-delta T cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
defense response to bacterium	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Tyrosine-protein kinase SYK	Homo sapiens (human)
mast cell degranulation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of mast cell degranulation	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of neutrophil degranulation	Tyrosine-protein kinase SYK	Homo sapiens (human)
beta selection	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of MAPK cascade	Tyrosine-protein kinase SYK	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of B cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of gamma-delta T cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of bone resorption	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of alpha-beta T cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of alpha-beta T cell proliferation	Tyrosine-protein kinase SYK	Homo sapiens (human)
blood vessel morphogenesis	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of phagocytosis	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of calcium-mediated signaling	Tyrosine-protein kinase SYK	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of killing of cells of another organism	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Tyrosine-protein kinase SYK	Homo sapiens (human)
cellular response to molecule of fungal origin	Tyrosine-protein kinase SYK	Homo sapiens (human)
cellular response to lipid	Tyrosine-protein kinase SYK	Homo sapiens (human)
cellular response to low-density lipoprotein particle stimulus	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of monocyte chemotactic protein-1 production	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of arachidonic acid secretion	Tyrosine-protein kinase SYK	Homo sapiens (human)
regulation of platelet aggregation	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Tyrosine-protein kinase SYK	Homo sapiens (human)
positive regulation of TORC1 signaling	Tyrosine-protein kinase SYK	Homo sapiens (human)
cellular response to lectin	Tyrosine-protein kinase SYK	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Tyrosine-protein kinase SYK	Homo sapiens (human)
cell differentiation	Tyrosine-protein kinase SYK	Homo sapiens (human)
blastocyst development	26S proteasome regulatory subunit 6B	Homo sapiens (human)
proteolysis	26S proteasome regulatory subunit 6B	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	26S proteasome regulatory subunit 6B	Homo sapiens (human)
positive regulation of proteasomal protein catabolic process	26S proteasome regulatory subunit 6B	Homo sapiens (human)
JUN phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to UV	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to lipopolysaccharide	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to oxidative stress	Mitogen-activated protein kinase 8	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase 8	Homo sapiens (human)
JUN phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of gene expression	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of macroautophagy	Mitogen-activated protein kinase 8	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
peptidyl-threonine phosphorylation	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of cyclase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of cell killing	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of protein binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of protein localization	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to oxidative stress	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 8	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Mitogen-activated protein kinase 8	Homo sapiens (human)
regulation of circadian rhythm	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
negative regulation of apoptotic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
rhythmic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of protein metabolic process	Mitogen-activated protein kinase 8	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 8	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 8	Homo sapiens (human)
energy homeostasis	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	Mitogen-activated protein kinase 8	Homo sapiens (human)
response to mechanical stimulus	Mitogen-activated protein kinase 8	Homo sapiens (human)
positive regulation of establishment of protein localization to mitochondrion	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 9	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of gene expression	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of macrophage derived foam cell differentiation	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of protein ubiquitination	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Mitogen-activated protein kinase 9	Homo sapiens (human)
cellular response to reactive oxygen species	Mitogen-activated protein kinase 9	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Mitogen-activated protein kinase 9	Homo sapiens (human)
regulation of circadian rhythm	Mitogen-activated protein kinase 9	Homo sapiens (human)
rhythmic process	Mitogen-activated protein kinase 9	Homo sapiens (human)
modulation of chemical synaptic transmission	Mitogen-activated protein kinase 9	Homo sapiens (human)
protein localization to tricellular tight junction	Mitogen-activated protein kinase 9	Homo sapiens (human)
cellular response to cadmium ion	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of podosome assembly	Mitogen-activated protein kinase 9	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 9	Homo sapiens (human)
inflammatory response to wounding	Mitogen-activated protein kinase 9	Homo sapiens (human)
apoptotic signaling pathway	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory response	Mitogen-activated protein kinase 9	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Mitogen-activated protein kinase 9	Homo sapiens (human)
regulation of cytokine production	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
response to ischemia	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
inflammatory response	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
signal transduction	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
heart development	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
negative regulation of hippo signaling	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
p38MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
positive regulation of MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
positive regulation of protein kinase activity	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
positive regulation of DNA-templated transcription	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cardiac muscle contraction	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cellular response to lipopolysaccharide	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cellular response to sorbitol	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cellular senescence	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
regulation of autophagy	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
megakaryocyte development	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
autophagosome-lysosome fusion	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
vesicle-mediated cholesterol transport	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
positive regulation of autophagosome assembly	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
protein phosphorylation	Casein kinase I isoform alpha	Homo sapiens (human)
Golgi organization	Casein kinase I isoform alpha	Homo sapiens (human)
cell surface receptor signaling pathway	Casein kinase I isoform alpha	Homo sapiens (human)
Wnt signaling pathway	Casein kinase I isoform alpha	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform alpha	Homo sapiens (human)
viral protein processing	Casein kinase I isoform alpha	Homo sapiens (human)
cellular response to nutrient	Casein kinase I isoform alpha	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Casein kinase I isoform alpha	Homo sapiens (human)
positive regulation of Rho protein signal transduction	Casein kinase I isoform alpha	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Casein kinase I isoform alpha	Homo sapiens (human)
intermediate filament cytoskeleton organization	Casein kinase I isoform alpha	Homo sapiens (human)
cell division	Casein kinase I isoform alpha	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Casein kinase I isoform alpha	Homo sapiens (human)
negative regulation of NLRP3 inflammasome complex assembly	Casein kinase I isoform alpha	Homo sapiens (human)
positive regulation of TORC1 signaling	Casein kinase I isoform alpha	Homo sapiens (human)
signal transduction	Casein kinase I isoform alpha	Homo sapiens (human)
microtubule nucleation	Casein kinase I isoform delta	Homo sapiens (human)
Golgi organization	Casein kinase I isoform delta	Homo sapiens (human)
protein localization to Golgi apparatus	Casein kinase I isoform delta	Homo sapiens (human)
protein localization to cilium	Casein kinase I isoform delta	Homo sapiens (human)
protein localization to centrosome	Casein kinase I isoform delta	Homo sapiens (human)
non-motile cilium assembly	Casein kinase I isoform delta	Homo sapiens (human)
positive regulation of protein phosphorylation	Casein kinase I isoform delta	Homo sapiens (human)
protein phosphorylation	Casein kinase I isoform delta	Homo sapiens (human)
Wnt signaling pathway	Casein kinase I isoform delta	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Casein kinase I isoform delta	Homo sapiens (human)
circadian regulation of gene expression	Casein kinase I isoform delta	Homo sapiens (human)
regulation of circadian rhythm	Casein kinase I isoform delta	Homo sapiens (human)
COPII vesicle coating	Casein kinase I isoform delta	Homo sapiens (human)
spindle assembly	Casein kinase I isoform delta	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform delta	Homo sapiens (human)
midbrain dopaminergic neuron differentiation	Casein kinase I isoform delta	Homo sapiens (human)
cellular response to nerve growth factor stimulus	Casein kinase I isoform delta	Homo sapiens (human)
positive regulation of non-canonical Wnt signaling pathway	Casein kinase I isoform delta	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform delta	Homo sapiens (human)
signal transduction	Casein kinase I isoform delta	Homo sapiens (human)
non-motile cilium assembly	Casein kinase I isoform delta	Homo sapiens (human)
endocytosis	Casein kinase I isoform delta	Homo sapiens (human)
MAPK cascade	MAP kinase-activated protein kinase 2	Homo sapiens (human)
toll-like receptor signaling pathway	MAP kinase-activated protein kinase 2	Homo sapiens (human)
protein phosphorylation	MAP kinase-activated protein kinase 2	Homo sapiens (human)
leukotriene metabolic process	MAP kinase-activated protein kinase 2	Homo sapiens (human)
inflammatory response	MAP kinase-activated protein kinase 2	Homo sapiens (human)
DNA damage response	MAP kinase-activated protein kinase 2	Homo sapiens (human)
regulation of tumor necrosis factor-mediated signaling pathway	MAP kinase-activated protein kinase 2	Homo sapiens (human)
peptidyl-serine phosphorylation	MAP kinase-activated protein kinase 2	Homo sapiens (human)
response to lipopolysaccharide	MAP kinase-activated protein kinase 2	Homo sapiens (human)
regulation of interleukin-6 production	MAP kinase-activated protein kinase 2	Homo sapiens (human)
regulation of tumor necrosis factor production	MAP kinase-activated protein kinase 2	Homo sapiens (human)
positive regulation of tumor necrosis factor production	MAP kinase-activated protein kinase 2	Homo sapiens (human)
response to cytokine	MAP kinase-activated protein kinase 2	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	MAP kinase-activated protein kinase 2	Homo sapiens (human)
p38MAPK cascade	MAP kinase-activated protein kinase 2	Homo sapiens (human)
regulation of mRNA stability	MAP kinase-activated protein kinase 2	Homo sapiens (human)
macropinocytosis	MAP kinase-activated protein kinase 2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	MAP kinase-activated protein kinase 2	Homo sapiens (human)
inner ear development	MAP kinase-activated protein kinase 2	Homo sapiens (human)
positive regulation of macrophage cytokine production	MAP kinase-activated protein kinase 2	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	MAP kinase-activated protein kinase 2	Homo sapiens (human)
regulation of cellular response to heat	MAP kinase-activated protein kinase 2	Homo sapiens (human)
protein autophosphorylation	MAP kinase-activated protein kinase 2	Homo sapiens (human)
intracellular signal transduction	MAP kinase-activated protein kinase 2	Homo sapiens (human)
translational elongation	Elongation factor Tu, mitochondrial	Homo sapiens (human)
response to ethanol	Elongation factor Tu, mitochondrial	Homo sapiens (human)
mitochondrial translational elongation	Elongation factor Tu, mitochondrial	Homo sapiens (human)
cysteinyl-tRNA aminoacylation	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
DNA repair	Casein kinase I isoform epsilon	Homo sapiens (human)
protein phosphorylation	Casein kinase I isoform epsilon	Homo sapiens (human)
protein localization	Casein kinase I isoform epsilon	Homo sapiens (human)
negative regulation of Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
negative regulation of protein binding	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Casein kinase I isoform epsilon	Homo sapiens (human)
regulation of protein localization	Casein kinase I isoform epsilon	Homo sapiens (human)
circadian regulation of gene expression	Casein kinase I isoform epsilon	Homo sapiens (human)
regulation of circadian rhythm	Casein kinase I isoform epsilon	Homo sapiens (human)
circadian behavior	Casein kinase I isoform epsilon	Homo sapiens (human)
canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of amyloid-beta formation	Casein kinase I isoform epsilon	Homo sapiens (human)
cellular response to nerve growth factor stimulus	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of non-canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform epsilon	Homo sapiens (human)
endocytosis	Casein kinase I isoform epsilon	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform epsilon	Homo sapiens (human)
signal transduction	Casein kinase I isoform epsilon	Homo sapiens (human)
temperature homeostasis	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
response to cold	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
energy derivation by oxidation of organic compounds	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
epithelial cell differentiation	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
fatty acid beta-oxidation using acyl-CoA dehydrogenase	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
negative regulation of fatty acid biosynthetic process	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
negative regulation of fatty acid oxidation	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
regulation of cholesterol metabolic process	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
regulation of RNA splicing	Dual specificity protein kinase CLK1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein phosphorylation	Dual specificity protein kinase CLK2	Homo sapiens (human)
response to ionizing radiation	Dual specificity protein kinase CLK2	Homo sapiens (human)
regulation of RNA splicing	Dual specificity protein kinase CLK2	Homo sapiens (human)
negative regulation of gluconeogenesis	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein autophosphorylation	Dual specificity protein kinase CLK2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein phosphorylation	Dual specificity protein kinase CLK3	Homo sapiens (human)
regulation of RNA splicing	Dual specificity protein kinase CLK3	Homo sapiens (human)
regulation of systemic arterial blood pressure	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cardiac left ventricle morphogenesis	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
glycogen metabolic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
protein phosphorylation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
dopamine receptor signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
nervous system development	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
insulin receptor signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of autophagy	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of gene expression	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of UDP-glucose catabolic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
Wnt signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cell migration	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
peptidyl-threonine phosphorylation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
viral protein processing	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of protein ubiquitination	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of TOR signaling	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cellular response to insulin stimulus	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cellular response to interleukin-3	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of glycogen biosynthetic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of protein catabolic process	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of heart contraction	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of glucose import	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
excitatory postsynaptic potential	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of cell growth involved in cardiac muscle cell development	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cellular response to lithium ion	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cellular response to glucocorticoid stimulus	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
extrinsic apoptotic signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
autosome genomic imprinting	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
regulation of mitophagy	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of amyloid-beta formation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of protein targeting to mitochondrion	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of type B pancreatic cell development	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
negative regulation of glycogen (starch) synthase activity	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of glycogen (starch) synthase activity	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cell differentiation	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
regulation of neuron projection development	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
positive regulation of gene expression	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of gene expression	Glycogen synthase kinase-3 beta	Homo sapiens (human)
ER overload response	Glycogen synthase kinase-3 beta	Homo sapiens (human)
peptidyl-serine phosphorylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
intracellular signal transduction	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of apoptotic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein export from nucleus	Glycogen synthase kinase-3 beta	Homo sapiens (human)
epithelial to mesenchymal transition	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of cell-matrix adhesion	Glycogen synthase kinase-3 beta	Homo sapiens (human)
glycogen metabolic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein phosphorylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
mitochondrion organization	Glycogen synthase kinase-3 beta	Homo sapiens (human)
dopamine receptor signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
circadian rhythm	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of autophagy	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of gene expression	Glycogen synthase kinase-3 beta	Homo sapiens (human)
peptidyl-serine phosphorylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
peptidyl-threonine phosphorylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
viral protein processing	Glycogen synthase kinase-3 beta	Homo sapiens (human)
hippocampus development	Glycogen synthase kinase-3 beta	Homo sapiens (human)
establishment of cell polarity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
maintenance of cell polarity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of cell migration	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of axon extension	Glycogen synthase kinase-3 beta	Homo sapiens (human)
neuron projection development	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein-containing complex assembly	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein ubiquitination	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of phosphoprotein phosphatase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of microtubule-based process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
intracellular signal transduction	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cellular response to interleukin-3	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of circadian rhythm	Glycogen synthase kinase-3 beta	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of GTPase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of cell differentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of osteoblast differentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of glycogen biosynthetic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of cilium assembly	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein catabolic process	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein autophosphorylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of protein export from nucleus	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of dendrite morphogenesis	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of axonogenesis	Glycogen synthase kinase-3 beta	Homo sapiens (human)
canonical Wnt signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
excitatory postsynaptic potential	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of calcineurin-NFAT signaling cascade	Glycogen synthase kinase-3 beta	Homo sapiens (human)
superior temporal gyrus development	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cellular response to retinoic acid	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
extrinsic apoptotic signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
extrinsic apoptotic signaling pathway in absence of ligand	Glycogen synthase kinase-3 beta	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Glycogen synthase kinase-3 beta	Homo sapiens (human)
neuron projection organization	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of microtubule anchoring at centrosome	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of cellular response to heat	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of protein localization to nucleus	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of long-term synaptic potentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of protein acetylation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein localization to cilium	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of dopaminergic neuron differentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cellular response to amyloid-beta	Glycogen synthase kinase-3 beta	Homo sapiens (human)
positive regulation of protein localization to centrosome	Glycogen synthase kinase-3 beta	Homo sapiens (human)
beta-catenin destruction complex disassembly	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of type B pancreatic cell development	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of glycogen (starch) synthase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of mesenchymal stem cell differentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
negative regulation of TOR signaling	Glycogen synthase kinase-3 beta	Homo sapiens (human)
regulation of neuron projection development	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cell differentiation	Glycogen synthase kinase-3 beta	Homo sapiens (human)
insulin receptor signaling pathway	Glycogen synthase kinase-3 beta	Homo sapiens (human)
DNA repair	Cyclin-dependent kinase 7	Homo sapiens (human)
transcription by RNA polymerase II	Cyclin-dependent kinase 7	Homo sapiens (human)
transcription initiation at RNA polymerase II promoter	Cyclin-dependent kinase 7	Homo sapiens (human)
snRNA transcription by RNA polymerase II	Cyclin-dependent kinase 7	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 7	Homo sapiens (human)
protein stabilization	Cyclin-dependent kinase 7	Homo sapiens (human)
cell division	Cyclin-dependent kinase 7	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 7	Homo sapiens (human)
regulation of G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 7	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 7	Homo sapiens (human)
regulation of mitotic cell cycle	Cyclin-dependent kinase 9	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 9	Homo sapiens (human)
DNA repair	Cyclin-dependent kinase 9	Homo sapiens (human)
regulation of DNA repair	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription by RNA polymerase II	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription initiation at RNA polymerase II promoter	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription elongation by RNA polymerase II	Cyclin-dependent kinase 9	Homo sapiens (human)
cell population proliferation	Cyclin-dependent kinase 9	Homo sapiens (human)
replication fork processing	Cyclin-dependent kinase 9	Homo sapiens (human)
regulation of mRNA 3'-end processing	Cyclin-dependent kinase 9	Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase II	Cyclin-dependent kinase 9	Homo sapiens (human)
positive regulation by host of viral transcription	Cyclin-dependent kinase 9	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 9	Homo sapiens (human)
regulation of muscle cell differentiation	Cyclin-dependent kinase 9	Homo sapiens (human)
nucleus localization	Cyclin-dependent kinase 9	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 9	Homo sapiens (human)
cellular response to cytokine stimulus	Cyclin-dependent kinase 9	Homo sapiens (human)
negative regulation of protein localization to chromatin	Cyclin-dependent kinase 9	Homo sapiens (human)
positive regulation of protein localization to chromatin	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription elongation-coupled chromatin remodeling	Cyclin-dependent kinase 9	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 9	Homo sapiens (human)
exocytosis	Ras-related protein Rab-27A	Homo sapiens (human)
blood coagulation	Ras-related protein Rab-27A	Homo sapiens (human)
protein secretion	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of gene expression	Ras-related protein Rab-27A	Homo sapiens (human)
antigen processing and presentation	Ras-related protein Rab-27A	Homo sapiens (human)
melanocyte differentiation	Ras-related protein Rab-27A	Homo sapiens (human)
melanosome localization	Ras-related protein Rab-27A	Homo sapiens (human)
melanosome transport	Ras-related protein Rab-27A	Homo sapiens (human)
multivesicular body organization	Ras-related protein Rab-27A	Homo sapiens (human)
cytotoxic T cell degranulation	Ras-related protein Rab-27A	Homo sapiens (human)
natural killer cell degranulation	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of exocytosis	Ras-related protein Rab-27A	Homo sapiens (human)
synaptic vesicle transport	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of phagocytosis	Ras-related protein Rab-27A	Homo sapiens (human)
multivesicular body sorting pathway	Ras-related protein Rab-27A	Homo sapiens (human)
complement-dependent cytotoxicity	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of regulated secretory pathway	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of reactive oxygen species biosynthetic process	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of constitutive secretory pathway	Ras-related protein Rab-27A	Homo sapiens (human)
exosomal secretion	Ras-related protein Rab-27A	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein autophosphorylation	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
regulation of cytokine-mediated signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
MyD88-dependent toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
canonical NF-kappaB signal transduction	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
JNK cascade	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of type I interferon production	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
response to lipopolysaccharide	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
toll-like receptor 2 signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
toll-like receptor 9 signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
cellular response to heat	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
interleukin-33-mediated signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein autophosphorylation	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
type I interferon-mediated signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
response to interleukin-1	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
cellular response to hypoxia	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of leukocyte adhesion to vascular endothelial cell	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
positive regulation of MAP kinase activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
cellular response to lipopolysaccharide	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
intracellular signal transduction	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
Toll signaling pathway	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
innate immune response	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
skeletal system development	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
toll-like receptor signaling pathway	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
signal transduction	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
chemical synaptic transmission	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
central nervous system development	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
positive regulation of cell growth	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
response to lipopolysaccharide	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
intracellular signal transduction	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
negative regulation of apoptotic process	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
regulation of translation in response to stress	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
positive regulation of cell differentiation	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
mitotic cell cycle	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
blastocyst development	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
chromosome segregation	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
regulation of mitotic nuclear division	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
regulation of mitotic centrosome separation	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
spindle assembly	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
centrosome separation	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
cell division	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
meiotic cell cycle	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
positive regulation of telomerase activity	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
regulation of attachment of spindle microtubules to kinetochore	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
mitotic spindle assembly	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
negative regulation of centriole-centriole cohesion	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
positive regulation of telomere capping	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
mitotic cell cycle	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
establishment of cell polarity	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
neuron projection morphogenesis	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
cell division	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
regulation of tubulin deacetylation	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
osteoblast differentiation	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of protein phosphorylation	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
response to ischemia	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
apoptotic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
signal transduction	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
response to xenobiotic stimulus	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
ovulation cycle process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of prostaglandin secretion	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
p38MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
signal transduction in response to DNA damage	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of apoptotic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
stress-activated MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
regulation of cell cycle	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
positive regulation of nitric-oxide synthase biosynthetic process	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cardiac muscle contraction	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
bone development	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cellular response to sorbitol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cellular senescence	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
T cell mediated cytotoxicity	Dipeptidyl peptidase 1	Homo sapiens (human)
proteolysis	Dipeptidyl peptidase 1	Homo sapiens (human)
apoptotic process	Dipeptidyl peptidase 1	Homo sapiens (human)
immune response	Dipeptidyl peptidase 1	Homo sapiens (human)
response to organic substance	Dipeptidyl peptidase 1	Homo sapiens (human)
negative regulation of myelination	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of proteolysis involved in protein catabolic process	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of microglial cell activation	Dipeptidyl peptidase 1	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Dipeptidyl peptidase 1	Homo sapiens (human)
proteolysis involved in protein catabolic process	Dipeptidyl peptidase 1	Homo sapiens (human)
protein phosphorylation	LIM domain kinase 1	Homo sapiens (human)
signal transduction	LIM domain kinase 1	Homo sapiens (human)
Rho protein signal transduction	LIM domain kinase 1	Homo sapiens (human)
nervous system development	LIM domain kinase 1	Homo sapiens (human)
positive regulation of actin filament bundle assembly	LIM domain kinase 1	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	LIM domain kinase 1	Homo sapiens (human)
stress fiber assembly	LIM domain kinase 1	Homo sapiens (human)
positive regulation of axon extension	LIM domain kinase 1	Homo sapiens (human)
axon extension	LIM domain kinase 1	Homo sapiens (human)
negative regulation of ubiquitin-protein transferase activity	LIM domain kinase 1	Homo sapiens (human)
positive regulation of stress fiber assembly	LIM domain kinase 1	Homo sapiens (human)
actin cytoskeleton organization	LIM domain kinase 1	Homo sapiens (human)
positive regulation of protein phosphorylation	LIM domain kinase 2	Homo sapiens (human)
protein phosphorylation	LIM domain kinase 2	Homo sapiens (human)
spermatogenesis	LIM domain kinase 2	Homo sapiens (human)
phosphorylation	LIM domain kinase 2	Homo sapiens (human)
astral microtubule organization	LIM domain kinase 2	Homo sapiens (human)
establishment of vesicle localization	LIM domain kinase 2	Homo sapiens (human)
head development	LIM domain kinase 2	Homo sapiens (human)
cornea development in camera-type eye	LIM domain kinase 2	Homo sapiens (human)
positive regulation of protein localization to nucleus	LIM domain kinase 2	Homo sapiens (human)
negative regulation of cilium assembly	LIM domain kinase 2	Homo sapiens (human)
actin cytoskeleton organization	LIM domain kinase 2	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase 10	Homo sapiens (human)
signal transduction	Mitogen-activated protein kinase 10	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase 10	Homo sapiens (human)
response to light stimulus	Mitogen-activated protein kinase 10	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Mitogen-activated protein kinase 10	Homo sapiens (human)
regulation of circadian rhythm	Mitogen-activated protein kinase 10	Homo sapiens (human)
rhythmic process	Mitogen-activated protein kinase 10	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 10	Homo sapiens (human)
tyrosyl-tRNA aminoacylation	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
apoptotic process	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
response to starvation	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
regulation of glycolytic process	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
protein phosphorylation	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
fatty acid biosynthetic process	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
signal transduction	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
spermatogenesis	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
positive regulation of gene expression	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
cellular response to nutrient levels	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
positive regulation of protein kinase activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
import into nucleus	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
regulation of catalytic activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
angiogenesis	Ephrin type-B receptor 3	Homo sapiens (human)
urogenital system development	Ephrin type-B receptor 3	Homo sapiens (human)
axon guidance	Ephrin type-B receptor 3	Homo sapiens (human)
axonal fasciculation	Ephrin type-B receptor 3	Homo sapiens (human)
cell migration	Ephrin type-B receptor 3	Homo sapiens (human)
central nervous system projection neuron axonogenesis	Ephrin type-B receptor 3	Homo sapiens (human)
corpus callosum development	Ephrin type-B receptor 3	Homo sapiens (human)
regulation of cell-cell adhesion	Ephrin type-B receptor 3	Homo sapiens (human)
retinal ganglion cell axon guidance	Ephrin type-B receptor 3	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Ephrin type-B receptor 3	Homo sapiens (human)
regulation of GTPase activity	Ephrin type-B receptor 3	Homo sapiens (human)
protein autophosphorylation	Ephrin type-B receptor 3	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-B receptor 3	Homo sapiens (human)
thymus development	Ephrin type-B receptor 3	Homo sapiens (human)
digestive tract morphogenesis	Ephrin type-B receptor 3	Homo sapiens (human)
regulation of axonogenesis	Ephrin type-B receptor 3	Homo sapiens (human)
positive regulation of synapse assembly	Ephrin type-B receptor 3	Homo sapiens (human)
roof of mouth development	Ephrin type-B receptor 3	Homo sapiens (human)
dendritic spine development	Ephrin type-B receptor 3	Homo sapiens (human)
dendritic spine morphogenesis	Ephrin type-B receptor 3	Homo sapiens (human)
protein phosphorylation	Ephrin type-B receptor 3	Homo sapiens (human)
axon guidance	Ephrin type-A receptor 5	Homo sapiens (human)
cAMP-mediated signaling	Ephrin type-A receptor 5	Homo sapiens (human)
hippocampus development	Ephrin type-A receptor 5	Homo sapiens (human)
positive regulation of CREB transcription factor activity	Ephrin type-A receptor 5	Homo sapiens (human)
regulation of actin cytoskeleton organization	Ephrin type-A receptor 5	Homo sapiens (human)
regulation of GTPase activity	Ephrin type-A receptor 5	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-A receptor 5	Homo sapiens (human)
neuron development	Ephrin type-A receptor 5	Homo sapiens (human)
regulation of insulin secretion involved in cellular response to glucose stimulus	Ephrin type-A receptor 5	Homo sapiens (human)
protein phosphorylation	Ephrin type-A receptor 5	Homo sapiens (human)
angiogenesis	Ephrin type-B receptor 4	Homo sapiens (human)
cell migration involved in sprouting angiogenesis	Ephrin type-B receptor 4	Homo sapiens (human)
heart morphogenesis	Ephrin type-B receptor 4	Homo sapiens (human)
cell adhesion	Ephrin type-B receptor 4	Homo sapiens (human)
protein autophosphorylation	Ephrin type-B receptor 4	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-B receptor 4	Homo sapiens (human)
multicellular organism development	Ephrin type-B receptor 4	Homo sapiens (human)
positive regulation of kinase activity	Ephrin type-B receptor 4	Homo sapiens (human)
negative regulation of cellular response to hypoxia	Ephrin type-A receptor 4	Homo sapiens (human)
cell adhesion	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of cell adhesion	Ephrin type-A receptor 4	Homo sapiens (human)
adult walking behavior	Ephrin type-A receptor 4	Homo sapiens (human)
motor neuron axon guidance	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of cell population proliferation	Ephrin type-A receptor 4	Homo sapiens (human)
glial cell migration	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of epithelial to mesenchymal transition	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of neuron projection development	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of translation	Ephrin type-A receptor 4	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Ephrin type-A receptor 4	Homo sapiens (human)
corticospinal tract morphogenesis	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of cell migration	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of cell migration	Ephrin type-A receptor 4	Homo sapiens (human)
adherens junction organization	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of GTPase activity	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of cell adhesion	Ephrin type-A receptor 4	Homo sapiens (human)
protein autophosphorylation	Ephrin type-A receptor 4	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of axon regeneration	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of astrocyte differentiation	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of axonogenesis	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of dendrite morphogenesis	Ephrin type-A receptor 4	Homo sapiens (human)
protein stabilization	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of dendritic spine morphogenesis	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of protein tyrosine kinase activity	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Ephrin type-A receptor 4	Homo sapiens (human)
nephric duct morphogenesis	Ephrin type-A receptor 4	Homo sapiens (human)
cochlea development	Ephrin type-A receptor 4	Homo sapiens (human)
fasciculation of sensory neuron axon	Ephrin type-A receptor 4	Homo sapiens (human)
fasciculation of motor neuron axon	Ephrin type-A receptor 4	Homo sapiens (human)
neuron projection guidance	Ephrin type-A receptor 4	Homo sapiens (human)
synapse pruning	Ephrin type-A receptor 4	Homo sapiens (human)
neuron projection fasciculation	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of amyloid-beta formation	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Ephrin type-A receptor 4	Homo sapiens (human)
negative regulation of proteolysis involved in protein catabolic process	Ephrin type-A receptor 4	Homo sapiens (human)
cellular response to amyloid-beta	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of modification of synaptic structure	Ephrin type-A receptor 4	Homo sapiens (human)
regulation of synapse pruning	Ephrin type-A receptor 4	Homo sapiens (human)
positive regulation of Rho guanyl-nucleotide exchange factor activity	Ephrin type-A receptor 4	Homo sapiens (human)
protein phosphorylation	Ephrin type-A receptor 4	Homo sapiens (human)
axon guidance	Ephrin type-A receptor 4	Homo sapiens (human)
ADP biosynthetic process	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
nucleobase-containing small molecule interconversion	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
AMP metabolic process	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
ATP metabolic process	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
nucleoside monophosphate phosphorylation	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
purine ribonucleoside salvage	Adenosine kinase	Homo sapiens (human)
dATP biosynthetic process	Adenosine kinase	Homo sapiens (human)
ribonucleoside monophosphate biosynthetic process	Adenosine kinase	Homo sapiens (human)
GMP salvage	Adenosine kinase	Homo sapiens (human)
AMP salvage	Adenosine kinase	Homo sapiens (human)
dAMP salvage	Adenosine kinase	Homo sapiens (human)
purine nucleobase metabolic process	Adenosine kinase	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 4	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 4	Homo sapiens (human)
chromatin remodeling	Histone deacetylase 4	Homo sapiens (human)
protein deacetylation	Histone deacetylase 4	Homo sapiens (human)
inflammatory response	Histone deacetylase 4	Homo sapiens (human)
nervous system development	Histone deacetylase 4	Homo sapiens (human)
positive regulation of cell population proliferation	Histone deacetylase 4	Homo sapiens (human)
negative regulation of myotube differentiation	Histone deacetylase 4	Homo sapiens (human)
negative regulation of transcription by competitive promoter binding	Histone deacetylase 4	Homo sapiens (human)
response to denervation involved in regulation of muscle adaptation	Histone deacetylase 4	Homo sapiens (human)
cardiac muscle hypertrophy in response to stress	Histone deacetylase 4	Homo sapiens (human)
protein sumoylation	Histone deacetylase 4	Homo sapiens (human)
B cell differentiation	Histone deacetylase 4	Homo sapiens (human)
positive regulation of protein sumoylation	Histone deacetylase 4	Homo sapiens (human)
peptidyl-lysine deacetylation	Histone deacetylase 4	Homo sapiens (human)
B cell activation	Histone deacetylase 4	Homo sapiens (human)
regulation of protein binding	Histone deacetylase 4	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Histone deacetylase 4	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Histone deacetylase 4	Homo sapiens (human)
negative regulation of glycolytic process	Histone deacetylase 4	Homo sapiens (human)
positive regulation of DNA-templated transcription	Histone deacetylase 4	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Histone deacetylase 4	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Histone deacetylase 4	Homo sapiens (human)
type I interferon-mediated signaling pathway	Histone deacetylase 4	Homo sapiens (human)
response to interleukin-1	Histone deacetylase 4	Homo sapiens (human)
Golgi to plasma membrane transport	Ras-related protein Rab-10	Homo sapiens (human)
axonogenesis	Ras-related protein Rab-10	Homo sapiens (human)
vesicle-mediated transport	Ras-related protein Rab-10	Homo sapiens (human)
endosomal transport	Ras-related protein Rab-10	Homo sapiens (human)
antigen processing and presentation	Ras-related protein Rab-10	Homo sapiens (human)
polarized epithelial cell differentiation	Ras-related protein Rab-10	Homo sapiens (human)
cellular response to insulin stimulus	Ras-related protein Rab-10	Homo sapiens (human)
Golgi to plasma membrane protein transport	Ras-related protein Rab-10	Homo sapiens (human)
regulated exocytosis	Ras-related protein Rab-10	Homo sapiens (human)
establishment of neuroblast polarity	Ras-related protein Rab-10	Homo sapiens (human)
endoplasmic reticulum tubular network organization	Ras-related protein Rab-10	Homo sapiens (human)
protein localization to plasma membrane	Ras-related protein Rab-10	Homo sapiens (human)
establishment of protein localization to membrane	Ras-related protein Rab-10	Homo sapiens (human)
establishment of protein localization to endoplasmic reticulum membrane	Ras-related protein Rab-10	Homo sapiens (human)
cell-cell adhesion	Ras-related protein Rab-10	Homo sapiens (human)
protein localization to basolateral plasma membrane	Ras-related protein Rab-10	Homo sapiens (human)
exocytosis	Ras-related protein Rab-10	Homo sapiens (human)
protein secretion	Ras-related protein Rab-10	Homo sapiens (human)
establishment or maintenance of cell polarity	Actin-related protein 3	Homo sapiens (human)
asymmetric cell division	Actin-related protein 3	Homo sapiens (human)
positive regulation of lamellipodium assembly	Actin-related protein 3	Homo sapiens (human)
meiotic chromosome movement towards spindle pole	Actin-related protein 3	Homo sapiens (human)
meiotic cytokinesis	Actin-related protein 3	Homo sapiens (human)
Arp2/3 complex-mediated actin nucleation	Actin-related protein 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Actin-related protein 3	Homo sapiens (human)
spindle localization	Actin-related protein 3	Homo sapiens (human)
cilium assembly	Actin-related protein 3	Homo sapiens (human)
actin polymerization-dependent cell motility	Actin-related protein 3	Homo sapiens (human)
cellular response to type II interferon	Actin-related protein 3	Homo sapiens (human)
regulation of double-strand break repair via nonhomologous end joining	Actin-related protein 2	Homo sapiens (human)
cilium assembly	Actin-related protein 2	Homo sapiens (human)
establishment or maintenance of cell polarity	Actin-related protein 2	Homo sapiens (human)
asymmetric cell division	Actin-related protein 2	Homo sapiens (human)
positive regulation of lamellipodium assembly	Actin-related protein 2	Homo sapiens (human)
meiotic chromosome movement towards spindle pole	Actin-related protein 2	Homo sapiens (human)
cytosolic transport	Actin-related protein 2	Homo sapiens (human)
meiotic cytokinesis	Actin-related protein 2	Homo sapiens (human)
Arp2/3 complex-mediated actin nucleation	Actin-related protein 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Actin-related protein 2	Homo sapiens (human)
spindle localization	Actin-related protein 2	Homo sapiens (human)
cellular response to type II interferon	Actin-related protein 2	Homo sapiens (human)
positive regulation of double-strand break repair via homologous recombination	Actin-related protein 2	Homo sapiens (human)
ribosomal large subunit export from nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
ribosomal small subunit export from nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
mitotic sister chromatid segregation	GTP-binding nuclear protein Ran	Homo sapiens (human)
mitotic cell cycle	GTP-binding nuclear protein Ran	Homo sapiens (human)
DNA metabolic process	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein import into nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein export from nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
mitotic spindle organization	GTP-binding nuclear protein Ran	Homo sapiens (human)
spermatid development	GTP-binding nuclear protein Ran	Homo sapiens (human)
viral process	GTP-binding nuclear protein Ran	Homo sapiens (human)
hippocampus development	GTP-binding nuclear protein Ran	Homo sapiens (human)
actin cytoskeleton organization	GTP-binding nuclear protein Ran	Homo sapiens (human)
positive regulation of protein binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
pre-miRNA export from nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
positive regulation of protein import into nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
GTP metabolic process	GTP-binding nuclear protein Ran	Homo sapiens (human)
cell division	GTP-binding nuclear protein Ran	Homo sapiens (human)
snRNA import into nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
cellular response to mineralocorticoid stimulus	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein localization to nucleolus	GTP-binding nuclear protein Ran	Homo sapiens (human)
ribosomal subunit export from nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein phosphorylation	Casein kinase I isoform gamma-2	Homo sapiens (human)
Wnt signaling pathway	Casein kinase I isoform gamma-2	Homo sapiens (human)
sphingolipid biosynthetic process	Casein kinase I isoform gamma-2	Homo sapiens (human)
signal transduction	Casein kinase I isoform gamma-2	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform gamma-2	Homo sapiens (human)
endocytosis	Casein kinase I isoform gamma-2	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform gamma-2	Homo sapiens (human)
DNA damage response	Cyclin-dependent kinase 3	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 3	Homo sapiens (human)
cell population proliferation	Cyclin-dependent kinase 3	Homo sapiens (human)
G0 to G1 transition	Cyclin-dependent kinase 3	Homo sapiens (human)
negative regulation of Notch signaling pathway	Cyclin-dependent kinase 3	Homo sapiens (human)
cell division	Cyclin-dependent kinase 3	Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 3	Homo sapiens (human)
response to organic substance	Cyclin-dependent kinase 3	Homo sapiens (human)
signal transduction	Cyclin-dependent kinase 3	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 3	Homo sapiens (human)
regulation of gene expression	Cyclin-dependent kinase 3	Homo sapiens (human)
G1/S transition of mitotic cell cycle	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 6	Homo sapiens (human)
positive regulation of cell-matrix adhesion	Cyclin-dependent kinase 6	Homo sapiens (human)
type B pancreatic cell development	Cyclin-dependent kinase 6	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 6	Homo sapiens (human)
Notch signaling pathway	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of cell population proliferation	Cyclin-dependent kinase 6	Homo sapiens (human)
response to virus	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of gene expression	Cyclin-dependent kinase 6	Homo sapiens (human)
positive regulation of gene expression	Cyclin-dependent kinase 6	Homo sapiens (human)
astrocyte development	Cyclin-dependent kinase 6	Homo sapiens (human)
dentate gyrus development	Cyclin-dependent kinase 6	Homo sapiens (human)
lateral ventricle development	Cyclin-dependent kinase 6	Homo sapiens (human)
T cell differentiation in thymus	Cyclin-dependent kinase 6	Homo sapiens (human)
gliogenesis	Cyclin-dependent kinase 6	Homo sapiens (human)
cell dedifferentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of cell differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of myeloid cell differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of erythrocyte differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of monocyte differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of osteoblast differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of cell cycle	Cyclin-dependent kinase 6	Homo sapiens (human)
positive regulation of fibroblast proliferation	Cyclin-dependent kinase 6	Homo sapiens (human)
generation of neurons	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of epithelial cell proliferation	Cyclin-dependent kinase 6	Homo sapiens (human)
cell division	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 6	Homo sapiens (human)
hematopoietic stem cell differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of hematopoietic stem cell differentiation	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of cell motility	Cyclin-dependent kinase 6	Homo sapiens (human)
negative regulation of cellular senescence	Cyclin-dependent kinase 6	Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycle	Cyclin-dependent kinase 6	Homo sapiens (human)
response to organic substance	Cyclin-dependent kinase 6	Homo sapiens (human)
signal transduction	Cyclin-dependent kinase 6	Homo sapiens (human)
microtubule cytoskeleton organization	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuron migration	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic transmission, dopaminergic	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
intracellular protein transport	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cell-matrix adhesion	Cyclin-dependent-like kinase 5	Homo sapiens (human)
chemical synaptic transmission	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synapse assembly	Cyclin-dependent-like kinase 5	Homo sapiens (human)
skeletal muscle tissue development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
motor neuron axon guidance	Cyclin-dependent-like kinase 5	Homo sapiens (human)
visual learning	Cyclin-dependent-like kinase 5	Homo sapiens (human)
Schwann cell development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic vesicle exocytosis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of macroautophagy	Cyclin-dependent-like kinase 5	Homo sapiens (human)
phosphorylation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
peptidyl-serine phosphorylation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
peptidyl-threonine phosphorylation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
sensory perception of pain	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cerebellar cortex formation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
hippocampus development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
layer formation in cerebral cortex	Cyclin-dependent-like kinase 5	Homo sapiens (human)
central nervous system neuron development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
corpus callosum development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuron differentiation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of cell migration	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of axon extension	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuron projection development	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of protein ubiquitination	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of synaptic plasticity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
receptor catabolic process	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic transmission, glutamatergic	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein localization to synapse	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of apoptotic process	Cyclin-dependent-like kinase 5	Homo sapiens (human)
receptor clustering	Cyclin-dependent-like kinase 5	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of cell cycle	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of proteolysis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of DNA-templated transcription	Cyclin-dependent-like kinase 5	Homo sapiens (human)
positive regulation of calcium ion-dependent exocytosis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
negative regulation of protein export from nucleus	Cyclin-dependent-like kinase 5	Homo sapiens (human)
behavioral response to cocaine	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of synaptic plasticity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic vesicle endocytosis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
rhythmic process	Cyclin-dependent-like kinase 5	Homo sapiens (human)
axon extension	Cyclin-dependent-like kinase 5	Homo sapiens (human)
oligodendrocyte differentiation	Cyclin-dependent-like kinase 5	Homo sapiens (human)
dendrite morphogenesis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cell division	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuron apoptotic process	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of synaptic transmission, glutamatergic	Cyclin-dependent-like kinase 5	Homo sapiens (human)
excitatory postsynaptic potential	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of dendritic spine morphogenesis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
calcium ion import	Cyclin-dependent-like kinase 5	Homo sapiens (human)
positive regulation of protein targeting to membrane	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of protein localization to plasma membrane	Cyclin-dependent-like kinase 5	Homo sapiens (human)
regulation of synaptic vesicle recycling	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cellular response to amyloid-beta	Cyclin-dependent-like kinase 5	Homo sapiens (human)
axonogenesis	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic vesicle transport	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 16	Homo sapiens (human)
exocytosis	Cyclin-dependent kinase 16	Homo sapiens (human)
spermatogenesis	Cyclin-dependent kinase 16	Homo sapiens (human)
positive regulation of autophagy	Cyclin-dependent kinase 16	Homo sapiens (human)
growth hormone secretion	Cyclin-dependent kinase 16	Homo sapiens (human)
neuron projection development	Cyclin-dependent kinase 16	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 16	Homo sapiens (human)
regulation of insulin secretion involved in cellular response to glucose stimulus	Cyclin-dependent kinase 16	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 17	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 17	Homo sapiens (human)
cellular response to leukemia inhibitory factor	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
canonical glycolysis	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
fructose 1,6-bisphosphate metabolic process	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
fructose 6-phosphate metabolic process	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
chemotaxis	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
signal transduction	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
heart development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
negative regulation of cell population proliferation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of gene expression	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
Schwann cell development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
cerebellar cortex formation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
keratinocyte differentiation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
thyroid gland development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
regulation of stress-activated MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
endodermal cell differentiation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
ERBB2-ERBB3 signaling pathway	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
myelination	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
type B pancreatic cell proliferation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
thymus development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
regulation of axon regeneration	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
cell motility	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of axonogenesis	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
Bergmann glial cell differentiation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
face development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
trachea formation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
epithelial cell proliferation involved in lung morphogenesis	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
placenta blood vessel development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
labyrinthine layer development	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
ERK1 and ERK2 cascade	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
regulation of Golgi inheritance	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
cellular senescence	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
positive regulation of endodermal cell differentiation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
regulation of early endosome to late endosome transport	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
neuron differentiation	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
neuron migration	DNA topoisomerase 2-beta	Homo sapiens (human)
DNA topological change	DNA topoisomerase 2-beta	Homo sapiens (human)
axonogenesis	DNA topoisomerase 2-beta	Homo sapiens (human)
B cell differentiation	DNA topoisomerase 2-beta	Homo sapiens (human)
forebrain development	DNA topoisomerase 2-beta	Homo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular response to hydrogen peroxide	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular response to ATP	DNA topoisomerase 2-beta	Homo sapiens (human)
cellular senescence	DNA topoisomerase 2-beta	Homo sapiens (human)
positive regulation of double-strand break repair via nonhomologous end joining	DNA topoisomerase 2-beta	Homo sapiens (human)
sister chromatid segregation	DNA topoisomerase 2-beta	Homo sapiens (human)
resolution of meiotic recombination intermediates	DNA topoisomerase 2-beta	Homo sapiens (human)
regulation of cell growth	Protein kinase C theta type	Homo sapiens (human)
regulation of DNA-templated transcription	Protein kinase C theta type	Homo sapiens (human)
protein phosphorylation	Protein kinase C theta type	Homo sapiens (human)
membrane protein ectodomain proteolysis	Protein kinase C theta type	Homo sapiens (human)
inflammatory response	Protein kinase C theta type	Homo sapiens (human)
axon guidance	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-17 production	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-2 production	Protein kinase C theta type	Homo sapiens (human)
positive regulation of interleukin-4 production	Protein kinase C theta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C theta type	Homo sapiens (human)
CD4-positive, alpha-beta T cell proliferation	Protein kinase C theta type	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Protein kinase C theta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T cell activation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomerase activity	Protein kinase C theta type	Homo sapiens (human)
cell chemotaxis	Protein kinase C theta type	Homo sapiens (human)
negative regulation of T cell apoptotic process	Protein kinase C theta type	Homo sapiens (human)
regulation of platelet aggregation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of telomere capping	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T-helper 17 type immune response	Protein kinase C theta type	Homo sapiens (human)
positive regulation of CD4-positive, alpha-beta T cell proliferation	Protein kinase C theta type	Homo sapiens (human)
positive regulation of T-helper 2 cell activation	Protein kinase C theta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C theta type	Homo sapiens (human)
outflow tract septum morphogenesis	Activin receptor type-1	Homo sapiens (human)
branching involved in blood vessel morphogenesis	Activin receptor type-1	Homo sapiens (human)
in utero embryonic development	Activin receptor type-1	Homo sapiens (human)
gastrulation with mouth forming second	Activin receptor type-1	Homo sapiens (human)
mesoderm formation	Activin receptor type-1	Homo sapiens (human)
neural crest cell migration	Activin receptor type-1	Homo sapiens (human)
acute inflammatory response	Activin receptor type-1	Homo sapiens (human)
embryonic heart tube morphogenesis	Activin receptor type-1	Homo sapiens (human)
atrioventricular valve morphogenesis	Activin receptor type-1	Homo sapiens (human)
mitral valve morphogenesis	Activin receptor type-1	Homo sapiens (human)
endocardial cushion formation	Activin receptor type-1	Homo sapiens (human)
endocardial cushion fusion	Activin receptor type-1	Homo sapiens (human)
atrial septum primum morphogenesis	Activin receptor type-1	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Activin receptor type-1	Homo sapiens (human)
germ cell development	Activin receptor type-1	Homo sapiens (human)
determination of left/right symmetry	Activin receptor type-1	Homo sapiens (human)
negative regulation of signal transduction	Activin receptor type-1	Homo sapiens (human)
regulation of ossification	Activin receptor type-1	Homo sapiens (human)
positive regulation of cell migration	Activin receptor type-1	Homo sapiens (human)
positive regulation of bone mineralization	Activin receptor type-1	Homo sapiens (human)
BMP signaling pathway	Activin receptor type-1	Homo sapiens (human)
activin receptor signaling pathway	Activin receptor type-1	Homo sapiens (human)
negative regulation of activin receptor signaling pathway	Activin receptor type-1	Homo sapiens (human)
positive regulation of osteoblast differentiation	Activin receptor type-1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Activin receptor type-1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Activin receptor type-1	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Activin receptor type-1	Homo sapiens (human)
smooth muscle cell differentiation	Activin receptor type-1	Homo sapiens (human)
pharyngeal system development	Activin receptor type-1	Homo sapiens (human)
positive regulation of SMAD protein signal transduction	Activin receptor type-1	Homo sapiens (human)
ventricular septum morphogenesis	Activin receptor type-1	Homo sapiens (human)
cardiac muscle cell fate commitment	Activin receptor type-1	Homo sapiens (human)
endocardial cushion cell fate commitment	Activin receptor type-1	Homo sapiens (human)
positive regulation of cardiac epithelial to mesenchymal transition	Activin receptor type-1	Homo sapiens (human)
cellular response to BMP stimulus	Activin receptor type-1	Homo sapiens (human)
positive regulation of determination of dorsal identity	Activin receptor type-1	Homo sapiens (human)
negative regulation of G1/S transition of mitotic cell cycle	Activin receptor type-1	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Activin receptor type-1	Homo sapiens (human)
dorsal/ventral pattern formation	Activin receptor type-1	Homo sapiens (human)
heart development	Activin receptor type-1	Homo sapiens (human)
protein phosphorylation	Activin receptor type-1	Homo sapiens (human)
cellular response to growth factor stimulus	Activin receptor type-1	Homo sapiens (human)
defense response	Macrophage-stimulating protein receptor	Homo sapiens (human)
signal transduction	Macrophage-stimulating protein receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Macrophage-stimulating protein receptor	Homo sapiens (human)
single fertilization	Macrophage-stimulating protein receptor	Homo sapiens (human)
positive regulation of cell population proliferation	Macrophage-stimulating protein receptor	Homo sapiens (human)
response to virus	Macrophage-stimulating protein receptor	Homo sapiens (human)
macrophage colony-stimulating factor signaling pathway	Macrophage-stimulating protein receptor	Homo sapiens (human)
positive regulation of MAP kinase activity	Macrophage-stimulating protein receptor	Homo sapiens (human)
innate immune response	Macrophage-stimulating protein receptor	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Macrophage-stimulating protein receptor	Homo sapiens (human)
nervous system development	Macrophage-stimulating protein receptor	Homo sapiens (human)
cell migration	Macrophage-stimulating protein receptor	Homo sapiens (human)
phagocytosis	Macrophage-stimulating protein receptor	Homo sapiens (human)
positive regulation of kinase activity	Macrophage-stimulating protein receptor	Homo sapiens (human)
multicellular organism development	Macrophage-stimulating protein receptor	Homo sapiens (human)
positive regulation of macrophage chemotaxis	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of macrophage proliferation	Focal adhesion kinase 1	Homo sapiens (human)
angiogenesis	Focal adhesion kinase 1	Homo sapiens (human)
placenta development	Focal adhesion kinase 1	Homo sapiens (human)
regulation of protein phosphorylation	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of protein phosphorylation	Focal adhesion kinase 1	Homo sapiens (human)
heart morphogenesis	Focal adhesion kinase 1	Homo sapiens (human)
signal complex assembly	Focal adhesion kinase 1	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
integrin-mediated signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
axon guidance	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of cell population proliferation	Focal adhesion kinase 1	Homo sapiens (human)
regulation of cell shape	Focal adhesion kinase 1	Homo sapiens (human)
regulation of endothelial cell migration	Focal adhesion kinase 1	Homo sapiens (human)
regulation of epithelial cell migration	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of epithelial cell migration	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of fibroblast migration	Focal adhesion kinase 1	Homo sapiens (human)
cell migration	Focal adhesion kinase 1	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Focal adhesion kinase 1	Homo sapiens (human)
negative regulation of cell-cell adhesion	Focal adhesion kinase 1	Homo sapiens (human)
establishment of cell polarity	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of cell migration	Focal adhesion kinase 1	Homo sapiens (human)
regulation of cell adhesion mediated by integrin	Focal adhesion kinase 1	Homo sapiens (human)
detection of muscle stretch	Focal adhesion kinase 1	Homo sapiens (human)
netrin-activated signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Focal adhesion kinase 1	Homo sapiens (human)
regulation of cell population proliferation	Focal adhesion kinase 1	Homo sapiens (human)
negative regulation of apoptotic process	Focal adhesion kinase 1	Homo sapiens (human)
regulation of GTPase activity	Focal adhesion kinase 1	Homo sapiens (human)
regulation of osteoblast differentiation	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of protein kinase activity	Focal adhesion kinase 1	Homo sapiens (human)
protein autophosphorylation	Focal adhesion kinase 1	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
ephrin receptor signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
cell motility	Focal adhesion kinase 1	Homo sapiens (human)
regulation of cytoskeleton organization	Focal adhesion kinase 1	Homo sapiens (human)
regulation of focal adhesion assembly	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Focal adhesion kinase 1	Homo sapiens (human)
growth hormone receptor signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of wound healing	Focal adhesion kinase 1	Homo sapiens (human)
regulation of substrate adhesion-dependent cell spreading	Focal adhesion kinase 1	Homo sapiens (human)
positive regulation of ubiquitin-dependent protein catabolic process	Focal adhesion kinase 1	Homo sapiens (human)
negative regulation of anoikis	Focal adhesion kinase 1	Homo sapiens (human)
protein phosphorylation	Focal adhesion kinase 1	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Focal adhesion kinase 1	Homo sapiens (human)
regulation of cell adhesion	Focal adhesion kinase 1	Homo sapiens (human)
protein phosphorylation	Protein kinase C delta type	Homo sapiens (human)
apoptotic process	Protein kinase C delta type	Homo sapiens (human)
DNA damage response	Protein kinase C delta type	Homo sapiens (human)
signal transduction	Protein kinase C delta type	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Protein kinase C delta type	Homo sapiens (human)
regulation of signaling receptor activity	Protein kinase C delta type	Homo sapiens (human)
immunoglobulin mediated immune response	Protein kinase C delta type	Homo sapiens (human)
peptidyl-serine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
peptidyl-threonine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
termination of signal transduction	Protein kinase C delta type	Homo sapiens (human)
negative regulation of actin filament polymerization	Protein kinase C delta type	Homo sapiens (human)
positive regulation of endodeoxyribonuclease activity	Protein kinase C delta type	Homo sapiens (human)
negative regulation of protein binding	Protein kinase C delta type	Homo sapiens (human)
activation of protein kinase activity	Protein kinase C delta type	Homo sapiens (human)
positive regulation of superoxide anion generation	Protein kinase C delta type	Homo sapiens (human)
regulation of actin cytoskeleton organization	Protein kinase C delta type	Homo sapiens (human)
negative regulation of glial cell apoptotic process	Protein kinase C delta type	Homo sapiens (human)
cellular response to UV	Protein kinase C delta type	Homo sapiens (human)
positive regulation of protein dephosphorylation	Protein kinase C delta type	Homo sapiens (human)
Fc-gamma receptor signaling pathway involved in phagocytosis	Protein kinase C delta type	Homo sapiens (human)
B cell proliferation	Protein kinase C delta type	Homo sapiens (human)
neutrophil activation	Protein kinase C delta type	Homo sapiens (human)
positive regulation of protein import into nucleus	Protein kinase C delta type	Homo sapiens (human)
defense response to bacterium	Protein kinase C delta type	Homo sapiens (human)
negative regulation of MAP kinase activity	Protein kinase C delta type	Homo sapiens (human)
regulation of mRNA stability	Protein kinase C delta type	Homo sapiens (human)
post-translational protein modification	Protein kinase C delta type	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Protein kinase C delta type	Homo sapiens (human)
negative regulation of inflammatory response	Protein kinase C delta type	Homo sapiens (human)
negative regulation of peptidyl-tyrosine phosphorylation	Protein kinase C delta type	Homo sapiens (human)
protein stabilization	Protein kinase C delta type	Homo sapiens (human)
negative regulation of filopodium assembly	Protein kinase C delta type	Homo sapiens (human)
cell chemotaxis	Protein kinase C delta type	Homo sapiens (human)
cellular response to hydrogen peroxide	Protein kinase C delta type	Homo sapiens (human)
cellular response to hydroperoxide	Protein kinase C delta type	Homo sapiens (human)
negative regulation of platelet aggregation	Protein kinase C delta type	Homo sapiens (human)
cellular senescence	Protein kinase C delta type	Homo sapiens (human)
positive regulation of phospholipid scramblase activity	Protein kinase C delta type	Homo sapiens (human)
cellular response to angiotensin	Protein kinase C delta type	Homo sapiens (human)
regulation of ceramide biosynthetic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of ceramide biosynthetic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of glucosylceramide catabolic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of sphingomyelin catabolic process	Protein kinase C delta type	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Protein kinase C delta type	Homo sapiens (human)
intracellular signal transduction	Protein kinase C delta type	Homo sapiens (human)
neutrophil homeostasis	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of type III hypersensitivity	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of type I hypersensitivity	Tyrosine-protein kinase BTK	Homo sapiens (human)
adaptive immune response	Tyrosine-protein kinase BTK	Homo sapiens (human)
B cell affinity maturation	Tyrosine-protein kinase BTK	Homo sapiens (human)
histamine secretion by mast cell	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of immunoglobulin production	Tyrosine-protein kinase BTK	Homo sapiens (human)
regulation of B cell cytokine production	Tyrosine-protein kinase BTK	Homo sapiens (human)
MyD88-dependent toll-like receptor signaling pathway	Tyrosine-protein kinase BTK	Homo sapiens (human)
regulation of B cell apoptotic process	Tyrosine-protein kinase BTK	Homo sapiens (human)
protein phosphorylation	Tyrosine-protein kinase BTK	Homo sapiens (human)
mesoderm development	Tyrosine-protein kinase BTK	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Tyrosine-protein kinase BTK	Homo sapiens (human)
calcium-mediated signaling	Tyrosine-protein kinase BTK	Homo sapiens (human)
proteoglycan catabolic process	Tyrosine-protein kinase BTK	Homo sapiens (human)
negative regulation of B cell proliferation	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of B cell proliferation	Tyrosine-protein kinase BTK	Homo sapiens (human)
response to lipopolysaccharide	Tyrosine-protein kinase BTK	Homo sapiens (human)
negative regulation of interleukin-10 production	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of interleukin-6 production	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Tyrosine-protein kinase BTK	Homo sapiens (human)
cellular response to reactive oxygen species	Tyrosine-protein kinase BTK	Homo sapiens (human)
intracellular signal transduction	Tyrosine-protein kinase BTK	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Tyrosine-protein kinase BTK	Homo sapiens (human)
B cell activation	Tyrosine-protein kinase BTK	Homo sapiens (human)
innate immune response	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of B cell differentiation	Tyrosine-protein kinase BTK	Homo sapiens (human)
cell maturation	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of phagocytosis	Tyrosine-protein kinase BTK	Homo sapiens (human)
B cell receptor signaling pathway	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Tyrosine-protein kinase BTK	Homo sapiens (human)
monocyte proliferation	Tyrosine-protein kinase BTK	Homo sapiens (human)
cellular response to molecule of fungal origin	Tyrosine-protein kinase BTK	Homo sapiens (human)
apoptotic signaling pathway	Tyrosine-protein kinase BTK	Homo sapiens (human)
cellular response to interleukin-7	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of interleukin-17A production	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	Tyrosine-protein kinase BTK	Homo sapiens (human)
positive regulation of synoviocyte proliferation	Tyrosine-protein kinase BTK	Homo sapiens (human)
eosinophil homeostasis	Tyrosine-protein kinase BTK	Homo sapiens (human)
T cell receptor signaling pathway	Tyrosine-protein kinase BTK	Homo sapiens (human)
endocytosis	Activated CDC42 kinase 1	Homo sapiens (human)
cell surface receptor signaling pathway	Activated CDC42 kinase 1	Homo sapiens (human)
small GTPase-mediated signal transduction	Activated CDC42 kinase 1	Homo sapiens (human)
phosphorylation	Activated CDC42 kinase 1	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Activated CDC42 kinase 1	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	Activated CDC42 kinase 1	Homo sapiens (human)
protein phosphorylation	Activated CDC42 kinase 1	Homo sapiens (human)
regulation of cell growth	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
regulation of cell-matrix adhesion	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
cell adhesion	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
embryo implantation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
lactation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
cell population proliferation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
negative regulation of cell population proliferation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
regulation of extracellular matrix disassembly	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
smooth muscle cell migration	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
collagen-activated tyrosine kinase receptor signaling pathway	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
ear development	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
wound healing, spreading of cells	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
protein autophosphorylation	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
branching involved in mammary gland duct morphogenesis	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
mammary gland alveolus development	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
smooth muscle cell-matrix adhesion	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
axon development	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
neuron projection extension	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
multicellular organism development	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
positive regulation of kinase activity	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
positive regulation of neuron projection development	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of heart rate by hormone	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of membrane potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion homeostasis	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cardiac muscle contraction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of ventricular cardiac muscle cell membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cellular response to xenobiotic stimulus	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
ventricular cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane depolarization during action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion export across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
membrane repolarization during ventricular cardiac muscle cell action potential	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
negative regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
positive regulation of potassium ion transmembrane transport	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
negative regulation of potassium ion export across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
potassium ion import across plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
vesicle targeting	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
immune response	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
positive regulation of JUN kinase activity	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
innate immune response	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
positive regulation of JNK cascade	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
cell morphogenesis	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of protein phosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of protein binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein stabilization	Serine/threonine-protein kinase 4	Homo sapiens (human)
branching involved in blood vessel morphogenesis	Serine/threonine-protein kinase 4	Homo sapiens (human)
neural tube formation	Serine/threonine-protein kinase 4	Homo sapiens (human)
endocardium development	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein import into nucleus	Serine/threonine-protein kinase 4	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase 4	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase 4	Homo sapiens (human)
central nervous system development	Serine/threonine-protein kinase 4	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Serine/threonine-protein kinase 4	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase 4	Homo sapiens (human)
keratinocyte differentiation	Serine/threonine-protein kinase 4	Homo sapiens (human)
organ growth	Serine/threonine-protein kinase 4	Homo sapiens (human)
hippo signaling	Serine/threonine-protein kinase 4	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of apoptotic process	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of fat cell differentiation	Serine/threonine-protein kinase 4	Homo sapiens (human)
negative regulation of organ growth	Serine/threonine-protein kinase 4	Homo sapiens (human)
epithelial cell proliferation	Serine/threonine-protein kinase 4	Homo sapiens (human)
negative regulation of epithelial cell proliferation	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein tetramerization	Serine/threonine-protein kinase 4	Homo sapiens (human)
canonical Wnt signaling pathway	Serine/threonine-protein kinase 4	Homo sapiens (human)
primitive hemopoiesis	Serine/threonine-protein kinase 4	Homo sapiens (human)
cell differentiation involved in embryonic placenta development	Serine/threonine-protein kinase 4	Homo sapiens (human)
regulation of cell differentiation involved in embryonic placenta development	Serine/threonine-protein kinase 4	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Serine/threonine-protein kinase 4	Homo sapiens (human)
hepatocyte apoptotic process	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of hepatocyte apoptotic process	Serine/threonine-protein kinase 4	Homo sapiens (human)
positive regulation of substrate-dependent cell migration, cell attachment to substrate	Serine/threonine-protein kinase 4	Homo sapiens (human)
regulation of MAPK cascade	Serine/threonine-protein kinase 4	Homo sapiens (human)
lipid droplet disassembly	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to hypoxia	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
glucose metabolic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
chromatin remodeling	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
fatty acid biosynthetic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cholesterol biosynthetic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
autophagy	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
signal transduction	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of cell population proliferation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
lipid biosynthetic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to UV	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cold acclimation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to gamma radiation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of autophagy	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of gene expression	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of gene expression	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
bile acid and bile salt transport	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
Wnt signaling pathway	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
fatty acid oxidation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to caffeine	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to nutrient levels	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of TOR signaling	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of peptidyl-serine phosphorylation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to oxidative stress	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
bile acid signaling pathway	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to glucose starvation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
glucose homeostasis	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of circadian rhythm	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of apoptotic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
response to estrogen	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of cholesterol biosynthetic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of glycolytic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of DNA-templated transcription	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of glucosylceramide biosynthetic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
rhythmic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of skeletal muscle tissue development	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of lipid catabolic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
fatty acid homeostasis	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of vesicle-mediated transport	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
motor behavior	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
CAMKK-AMPK signaling cascade	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of stress granule assembly	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
neuron cellular homeostasis	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to hydrogen peroxide	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to calcium ion	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to glucose stimulus	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to ethanol	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to prostaglandin E stimulus	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to organonitrogen compound	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to hypoxia	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cellular response to xenobiotic stimulus	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
energy homeostasis	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
regulation of bile acid secretion	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of mitochondrial transcription	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of protein localization	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of hepatocyte apoptotic process	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of protein targeting to mitochondrion	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of adipose tissue development	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of TORC1 signaling	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of tubulin deacetylation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein localization to lipid droplet	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
positive regulation of peptidyl-lysine acetylation	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
MAPK cascade	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
signal transduction	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
heart development	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
positive regulation of cell growth	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of interleukin-8 production	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of heterotypic cell-cell adhesion	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of smooth muscle cell apoptotic process	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
positive regulation of MAP kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
insulin-like growth factor receptor signaling pathway	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
positive regulation of epithelial cell proliferation	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
positive regulation of protein metabolic process	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of response to cytokine stimulus	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
ERK5 cascade	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
cellular response to growth factor stimulus	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
cellular response to laminar fluid shear stress	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of cell migration involved in sprouting angiogenesis	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of chemokine (C-X-C motif) ligand 2 production	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase 7	Homo sapiens (human)
signal transduction	Mitogen-activated protein kinase 7	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Mitogen-activated protein kinase 7	Homo sapiens (human)
cell differentiation	Mitogen-activated protein kinase 7	Homo sapiens (human)
calcineurin-NFAT signaling cascade	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of heterotypic cell-cell adhesion	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of smooth muscle cell apoptotic process	Mitogen-activated protein kinase 7	Homo sapiens (human)
regulation of angiogenesis	Mitogen-activated protein kinase 7	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of inflammatory response	Mitogen-activated protein kinase 7	Homo sapiens (human)
positive regulation of protein metabolic process	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of response to cytokine stimulus	Mitogen-activated protein kinase 7	Homo sapiens (human)
cellular response to hydrogen peroxide	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of calcineurin-NFAT signaling cascade	Mitogen-activated protein kinase 7	Homo sapiens (human)
cellular response to growth factor stimulus	Mitogen-activated protein kinase 7	Homo sapiens (human)
cellular response to laminar fluid shear stress	Mitogen-activated protein kinase 7	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Mitogen-activated protein kinase 7	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Mitogen-activated protein kinase 7	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 7	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
stimulatory C-type lectin receptor signaling pathway	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cardiac muscle hypertrophy	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
negative regulation of protein kinase activity	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
adherens junction assembly	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
negative regulation of apoptotic process	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
regulation of cytoskeleton organization	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
negative regulation of stress fiber assembly	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
dendritic spine development	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
bicellular tight junction assembly	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cellular response to organic cyclic compound	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein localization to cell-cell junction	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
regulation of axonogenesis	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
regulation of MAPK cascade	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
positive regulation of protein binding	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein stabilization	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Serine/threonine-protein kinase 3	Homo sapiens (human)
neural tube formation	Serine/threonine-protein kinase 3	Homo sapiens (human)
endocardium development	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein import into nucleus	Serine/threonine-protein kinase 3	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase 3	Homo sapiens (human)
JNK cascade	Serine/threonine-protein kinase 3	Homo sapiens (human)
central nervous system development	Serine/threonine-protein kinase 3	Homo sapiens (human)
extrinsic apoptotic signaling pathway via death domain receptors	Serine/threonine-protein kinase 3	Homo sapiens (human)
organ growth	Serine/threonine-protein kinase 3	Homo sapiens (human)
hippo signaling	Serine/threonine-protein kinase 3	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of apoptotic process	Serine/threonine-protein kinase 3	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of fat cell differentiation	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of JNK cascade	Serine/threonine-protein kinase 3	Homo sapiens (human)
negative regulation of organ growth	Serine/threonine-protein kinase 3	Homo sapiens (human)
epithelial cell proliferation	Serine/threonine-protein kinase 3	Homo sapiens (human)
negative regulation of epithelial cell proliferation	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein tetramerization	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase 3	Homo sapiens (human)
canonical Wnt signaling pathway	Serine/threonine-protein kinase 3	Homo sapiens (human)
primitive hemopoiesis	Serine/threonine-protein kinase 3	Homo sapiens (human)
cell differentiation involved in embryonic placenta development	Serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of cell differentiation involved in embryonic placenta development	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein localization to centrosome	Serine/threonine-protein kinase 3	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Serine/threonine-protein kinase 3	Homo sapiens (human)
hepatocyte apoptotic process	Serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of MAPK cascade	Serine/threonine-protein kinase 3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
Fc-epsilon receptor signaling pathway	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
cell morphogenesis	Integrin-linked protein kinase	Homo sapiens (human)
integrin-mediated signaling pathway	Integrin-linked protein kinase	Homo sapiens (human)
branching involved in ureteric bud morphogenesis	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of protein phosphorylation	Integrin-linked protein kinase	Homo sapiens (human)
outflow tract morphogenesis	Integrin-linked protein kinase	Homo sapiens (human)
protein phosphorylation	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of cell population proliferation	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of signal transduction	Integrin-linked protein kinase	Homo sapiens (human)
fibroblast migration	Integrin-linked protein kinase	Homo sapiens (human)
nerve development	Integrin-linked protein kinase	Homo sapiens (human)
myelination in peripheral nervous system	Integrin-linked protein kinase	Homo sapiens (human)
cell projection organization	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of BMP signaling pathway	Integrin-linked protein kinase	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Integrin-linked protein kinase	Homo sapiens (human)
substrate adhesion-dependent cell spreading	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of phosphorylation	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Integrin-linked protein kinase	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Integrin-linked protein kinase	Homo sapiens (human)
establishment or maintenance of epithelial cell apical/basal polarity	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of osteoblast differentiation	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of DNA-templated transcription	Integrin-linked protein kinase	Homo sapiens (human)
neural precursor cell proliferation	Integrin-linked protein kinase	Homo sapiens (human)
platelet aggregation	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Integrin-linked protein kinase	Homo sapiens (human)
positive regulation of substrate adhesion-dependent cell spreading	Integrin-linked protein kinase	Homo sapiens (human)
negative regulation of neural precursor cell proliferation	Integrin-linked protein kinase	Homo sapiens (human)
cell-matrix adhesion	Integrin-linked protein kinase	Homo sapiens (human)
integrin-mediated signaling pathway	Integrin-linked protein kinase	Homo sapiens (human)
epithelial to mesenchymal transition	Rho-associated protein kinase 1	Homo sapiens (human)
aortic valve morphogenesis	Rho-associated protein kinase 1	Homo sapiens (human)
apical constriction	Rho-associated protein kinase 1	Homo sapiens (human)
protein phosphorylation	Rho-associated protein kinase 1	Homo sapiens (human)
smooth muscle contraction	Rho-associated protein kinase 1	Homo sapiens (human)
leukocyte cell-cell adhesion	Rho-associated protein kinase 1	Homo sapiens (human)
signal transduction	Rho-associated protein kinase 1	Homo sapiens (human)
canonical NF-kappaB signal transduction	Rho-associated protein kinase 1	Homo sapiens (human)
Rho protein signal transduction	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of autophagy	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of cardiac muscle hypertrophy	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of gene expression	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of phosphatase activity	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of angiogenesis	Rho-associated protein kinase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	Rho-associated protein kinase 1	Homo sapiens (human)
membrane to membrane docking	Rho-associated protein kinase 1	Homo sapiens (human)
actin cytoskeleton organization	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of cell adhesion	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of cell migration	Rho-associated protein kinase 1	Homo sapiens (human)
cortical actin cytoskeleton organization	Rho-associated protein kinase 1	Homo sapiens (human)
neuron projection development	Rho-associated protein kinase 1	Homo sapiens (human)
bleb assembly	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of protein binding	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of actin cytoskeleton organization	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of dephosphorylation	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of myosin-light-chain-phosphatase activity	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of phosphorylation	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of MAPK cascade	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of keratinocyte differentiation	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of neuron differentiation	Rho-associated protein kinase 1	Homo sapiens (human)
leukocyte migration	Rho-associated protein kinase 1	Homo sapiens (human)
leukocyte tethering or rolling	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of membrane protein ectodomain proteolysis	Rho-associated protein kinase 1	Homo sapiens (human)
myoblast migration	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of stress fiber assembly	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of focal adhesion assembly	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of focal adhesion assembly	Rho-associated protein kinase 1	Homo sapiens (human)
mRNA destabilization	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of biomineral tissue development	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Rho-associated protein kinase 1	Homo sapiens (human)
response to transforming growth factor beta	Rho-associated protein kinase 1	Homo sapiens (human)
protein localization to plasma membrane	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of synapse maturation	Rho-associated protein kinase 1	Homo sapiens (human)
podocyte cell migration	Rho-associated protein kinase 1	Homo sapiens (human)
motor neuron apoptotic process	Rho-associated protein kinase 1	Homo sapiens (human)
blood vessel diameter maintenance	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of angiotensin-activated signaling pathway	Rho-associated protein kinase 1	Homo sapiens (human)
neuron projection arborization	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of amyloid-beta clearance	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of synaptic vesicle endocytosis	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of amyloid-beta formation	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of amyloid precursor protein catabolic process	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of establishment of endothelial barrier	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of bicellular tight junction assembly	Rho-associated protein kinase 1	Homo sapiens (human)
positive regulation of connective tissue replacement	Rho-associated protein kinase 1	Homo sapiens (human)
response to angiotensin	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of establishment of cell polarity	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of cell motility	Rho-associated protein kinase 1	Homo sapiens (human)
negative regulation of motor neuron apoptotic process	Rho-associated protein kinase 1	Homo sapiens (human)
regulation of cell junction assembly	Rho-associated protein kinase 1	Homo sapiens (human)
mitotic cytokinesis	Rho-associated protein kinase 1	Homo sapiens (human)
embryonic morphogenesis	Rho-associated protein kinase 1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Rho-associated protein kinase 1	Homo sapiens (human)
actomyosin structure organization	Rho-associated protein kinase 1	Homo sapiens (human)
protein phosphorylation	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
protein autophosphorylation	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
negative regulation of myotube differentiation	Histone deacetylase 1	Homo sapiens (human)
negative regulation of apoptotic process	Histone deacetylase 1	Homo sapiens (human)
positive regulation of signaling receptor activity	Histone deacetylase 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 1	Homo sapiens (human)
chromatin organization	Histone deacetylase 1	Homo sapiens (human)
chromatin remodeling	Histone deacetylase 1	Homo sapiens (human)
DNA methylation-dependent heterochromatin formation	Histone deacetylase 1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Histone deacetylase 1	Homo sapiens (human)
protein deacetylation	Histone deacetylase 1	Homo sapiens (human)
endoderm development	Histone deacetylase 1	Homo sapiens (human)
positive regulation of cell population proliferation	Histone deacetylase 1	Homo sapiens (human)
epidermal cell differentiation	Histone deacetylase 1	Homo sapiens (human)
positive regulation of gene expression	Histone deacetylase 1	Homo sapiens (human)
negative regulation of gene expression	Histone deacetylase 1	Homo sapiens (human)
hippocampus development	Histone deacetylase 1	Homo sapiens (human)
neuron differentiation	Histone deacetylase 1	Homo sapiens (human)
negative regulation of cell migration	Histone deacetylase 1	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Histone deacetylase 1	Homo sapiens (human)
circadian regulation of gene expression	Histone deacetylase 1	Homo sapiens (human)
cellular response to platelet-derived growth factor stimulus	Histone deacetylase 1	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Histone deacetylase 1	Homo sapiens (human)
regulation of cell fate specification	Histone deacetylase 1	Homo sapiens (human)
embryonic digit morphogenesis	Histone deacetylase 1	Homo sapiens (human)
negative regulation of apoptotic process	Histone deacetylase 1	Homo sapiens (human)
negative regulation of canonical NF-kappaB signal transduction	Histone deacetylase 1	Homo sapiens (human)
negative regulation by host of viral transcription	Histone deacetylase 1	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Histone deacetylase 1	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Histone deacetylase 1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Histone deacetylase 1	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Histone deacetylase 1	Homo sapiens (human)
oligodendrocyte differentiation	Histone deacetylase 1	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Histone deacetylase 1	Homo sapiens (human)
negative regulation of androgen receptor signaling pathway	Histone deacetylase 1	Homo sapiens (human)
hair follicle placode formation	Histone deacetylase 1	Homo sapiens (human)
eyelid development in camera-type eye	Histone deacetylase 1	Homo sapiens (human)
fungiform papilla formation	Histone deacetylase 1	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Histone deacetylase 1	Homo sapiens (human)
negative regulation of stem cell population maintenance	Histone deacetylase 1	Homo sapiens (human)
positive regulation of stem cell population maintenance	Histone deacetylase 1	Homo sapiens (human)
regulation of stem cell differentiation	Histone deacetylase 1	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	Histone deacetylase 1	Homo sapiens (human)
heterochromatin formation	Histone deacetylase 1	Homo sapiens (human)
nervous system development	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
regulation of neuron projection development	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
regulation of skeletal muscle adaptation	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
insulin secretion	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
cell differentiation	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
regulation of calcium ion transport	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
regulation of cell growth	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of the force of heart contraction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of membrane depolarization	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein phosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of heart contraction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
positive regulation of cardiac muscle hypertrophy	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cell communication by electrical coupling	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
peptidyl-serine phosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
peptidyl-threonine phosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
endoplasmic reticulum calcium ion homeostasis	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein autophosphorylation	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
relaxation of cardiac muscle	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of ryanodine-sensitive calcium-release channel activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cellular localization	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cellular response to calcium ion	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cardiac muscle cell contraction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of heart rate by cardiac conduction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cardiac muscle cell action potential	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cardiac muscle cell action potential involved in regulation of contraction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of cell communication by electrical coupling involved in cardiac conduction	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of relaxation of cardiac muscle	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
negative regulation of sodium ion transmembrane transport	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
negative regulation of sodium ion transmembrane transporter activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
chromatin remodeling	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein phosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
nervous system development	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
circadian rhythm	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
peptidyl-serine phosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
peptidyl-threonine phosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
negative regulation of microtubule polymerization	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
positive regulation of RNA splicing	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
amyloid-beta formation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
peptidyl-serine autophosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
negative regulation of DNA damage response, signal transduction by p53 class mediator	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein autophosphorylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
negative regulation of mRNA splicing, via spliceosome	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
negative regulation of DNA methylation-dependent heterochromatin formation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
positive regulation of protein deacetylation	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
positive regulation of DNA-templated transcription	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Activin receptor type-2B	Homo sapiens (human)
gastrulation with mouth forming second	Activin receptor type-2B	Homo sapiens (human)
kidney development	Activin receptor type-2B	Homo sapiens (human)
lymphangiogenesis	Activin receptor type-2B	Homo sapiens (human)
blood vessel remodeling	Activin receptor type-2B	Homo sapiens (human)
regulation of DNA-templated transcription	Activin receptor type-2B	Homo sapiens (human)
signal transduction	Activin receptor type-2B	Homo sapiens (human)
cell surface receptor protein serine/threonine kinase signaling pathway	Activin receptor type-2B	Homo sapiens (human)
determination of left/right symmetry	Activin receptor type-2B	Homo sapiens (human)
mesoderm development	Activin receptor type-2B	Homo sapiens (human)
heart development	Activin receptor type-2B	Homo sapiens (human)
response to glucose	Activin receptor type-2B	Homo sapiens (human)
post-embryonic development	Activin receptor type-2B	Homo sapiens (human)
anterior/posterior pattern specification	Activin receptor type-2B	Homo sapiens (human)
insulin secretion	Activin receptor type-2B	Homo sapiens (human)
lung development	Activin receptor type-2B	Homo sapiens (human)
positive regulation of bone mineralization	Activin receptor type-2B	Homo sapiens (human)
BMP signaling pathway	Activin receptor type-2B	Homo sapiens (human)
pancreas development	Activin receptor type-2B	Homo sapiens (human)
activin receptor signaling pathway	Activin receptor type-2B	Homo sapiens (human)
positive regulation of activin receptor signaling pathway	Activin receptor type-2B	Homo sapiens (human)
organ growth	Activin receptor type-2B	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Activin receptor type-2B	Homo sapiens (human)
positive regulation of osteoblast differentiation	Activin receptor type-2B	Homo sapiens (human)
embryonic foregut morphogenesis	Activin receptor type-2B	Homo sapiens (human)
skeletal system morphogenesis	Activin receptor type-2B	Homo sapiens (human)
roof of mouth development	Activin receptor type-2B	Homo sapiens (human)
lymphatic endothelial cell differentiation	Activin receptor type-2B	Homo sapiens (human)
artery development	Activin receptor type-2B	Homo sapiens (human)
venous blood vessel development	Activin receptor type-2B	Homo sapiens (human)
retina vasculature development in camera-type eye	Activin receptor type-2B	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Activin receptor type-2B	Homo sapiens (human)
cellular response to growth factor stimulus	Activin receptor type-2B	Homo sapiens (human)
protein phosphorylation	Activin receptor type-2B	Homo sapiens (human)
outflow tract septum morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
atrioventricular valve morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cardiac muscle tissue development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
pharyngeal arch artery morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of gene expression	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of SMAD protein signal transduction	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
osteoblast differentiation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
mesoderm formation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
maternal placenta development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
endothelial cell proliferation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
lymphangiogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
blood vessel remodeling	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
chondrocyte development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of systemic arterial blood pressure	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
outflow tract morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
aortic valve development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
pulmonary valve development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
mitral valve morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
tricuspid valve morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
endocardial cushion development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of cell proliferation involved in heart valve morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cell surface receptor protein serine/threonine kinase signaling pathway	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cellular response to starvation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
anterior/posterior pattern specification	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of epithelial cell migration	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
regulation of lung blood pressure	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
proteoglycan biosynthetic process	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of cell growth	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of bone mineralization	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
BMP signaling pathway	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
activin receptor signaling pathway	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
regulation of cell population proliferation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of osteoblast differentiation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of ossification	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of vasoconstriction	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
lung alveolus development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of smooth muscle cell proliferation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of axon extension involved in axon guidance	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of muscle cell differentiation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
limb development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
endochondral bone morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of SMAD protein signal transduction	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
ventricular septum morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
atrial septum morphogenesis	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
lung vasculature development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
lymphatic endothelial cell differentiation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
artery development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
venous blood vessel development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
positive regulation of cartilage development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
retina vasculature development in camera-type eye	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cellular response to BMP stimulus	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
endothelial cell apoptotic process	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
negative regulation of chondrocyte proliferation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
semi-lunar valve development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cellular response to growth factor stimulus	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
blood vessel development	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
protein phosphorylation	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
protein phosphorylation	Protein-tyrosine kinase 6	Homo sapiens (human)
tyrosine phosphorylation of STAT protein	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of neuron projection development	Protein-tyrosine kinase 6	Homo sapiens (human)
cell migration	Protein-tyrosine kinase 6	Homo sapiens (human)
ERBB2 signaling pathway	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of DNA replication	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of epidermal growth factor receptor signaling pathway	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of cell cycle	Protein-tyrosine kinase 6	Homo sapiens (human)
negative regulation of growth	Protein-tyrosine kinase 6	Homo sapiens (human)
protein autophosphorylation	Protein-tyrosine kinase 6	Homo sapiens (human)
intestinal epithelial cell differentiation	Protein-tyrosine kinase 6	Homo sapiens (human)
negative regulation of protein tyrosine kinase activity	Protein-tyrosine kinase 6	Homo sapiens (human)
cellular response to retinoic acid	Protein-tyrosine kinase 6	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Protein-tyrosine kinase 6	Homo sapiens (human)
innate immune response	Protein-tyrosine kinase 6	Homo sapiens (human)
cell differentiation	Protein-tyrosine kinase 6	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Protein-tyrosine kinase 6	Homo sapiens (human)
protein phosphorylation	cGMP-dependent protein kinase 1	Homo sapiens (human)
neuron migration	cGMP-dependent protein kinase 1	Homo sapiens (human)
signal transduction	cGMP-dependent protein kinase 1	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	cGMP-dependent protein kinase 1	Homo sapiens (human)
spermatid development	cGMP-dependent protein kinase 1	Homo sapiens (human)
negative regulation of inositol phosphate biosynthetic process	cGMP-dependent protein kinase 1	Homo sapiens (human)
negative regulation of glutamate secretion	cGMP-dependent protein kinase 1	Homo sapiens (human)
dendrite development	cGMP-dependent protein kinase 1	Homo sapiens (human)
cGMP-mediated signaling	cGMP-dependent protein kinase 1	Homo sapiens (human)
cerebellum development	cGMP-dependent protein kinase 1	Homo sapiens (human)
actin cytoskeleton organization	cGMP-dependent protein kinase 1	Homo sapiens (human)
forebrain development	cGMP-dependent protein kinase 1	Homo sapiens (human)
positive regulation of circadian rhythm	cGMP-dependent protein kinase 1	Homo sapiens (human)
regulation of GTPase activity	cGMP-dependent protein kinase 1	Homo sapiens (human)
collateral sprouting	cGMP-dependent protein kinase 1	Homo sapiens (human)
relaxation of vascular associated smooth muscle	cGMP-dependent protein kinase 1	Homo sapiens (human)
cell growth involved in cardiac muscle cell development	cGMP-dependent protein kinase 1	Homo sapiens (human)
negative regulation of platelet aggregation	cGMP-dependent protein kinase 1	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell proliferation	cGMP-dependent protein kinase 1	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell migration	cGMP-dependent protein kinase 1	Homo sapiens (human)
regulation of testosterone biosynthetic process	cGMP-dependent protein kinase 1	Homo sapiens (human)
protein kinase A signaling	cGMP-dependent protein kinase 1	Homo sapiens (human)
alternative mRNA splicing, via spliceosome	Cyclin-dependent kinase 13	Homo sapiens (human)
regulation of signal transduction	Cyclin-dependent kinase 13	Homo sapiens (human)
hemopoiesis	Cyclin-dependent kinase 13	Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase II	Cyclin-dependent kinase 13	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 13	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 13	Homo sapiens (human)
negative regulation of stem cell differentiation	Cyclin-dependent kinase 13	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 13	Homo sapiens (human)
immune response	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
gene expression	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of lipid storage	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of type I interferon production	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
response to interferon-beta	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
regulation of protein-containing complex assembly	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
mRNA stabilization	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
defense response to virus	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
type I interferon-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of type I interferon-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
interleukin-17-mediated signaling pathway	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
cellular response to virus	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
peptidyl-serine phosphorylation	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
MAPK cascade	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
oocyte maturation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to hypoxia	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of cell-matrix adhesion	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
sprouting angiogenesis	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
adaptive immune response	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
marginal zone B cell differentiation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to ischemia	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein phosphorylation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
apoptotic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cellular defense response	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
signal transduction	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cell surface receptor signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
signal complex assembly	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
integrin-mediated signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of cell population proliferation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of cell population proliferation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of cell shape	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to xenobiotic stimulus	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to mechanical stimulus	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to hormone	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to glucose	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of endothelial cell migration	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of muscle cell apoptotic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of macrophage chemotaxis	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of neuron projection development	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
glial cell proliferation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of cell adhesion	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of cell growth	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of cell migration	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of bone mineralization	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of actin filament polymerization	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cortical cytoskeleton organization	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
neuron projection development	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of actin cytoskeleton organization	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
ionotropic glutamate receptor signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to immobilization stress	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to cocaine	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to hydrogen peroxide	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
activation of Janus kinase activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of apoptotic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
stress fiber assembly	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to cation stress	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of potassium ion transport	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of neuron apoptotic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
blood vessel endothelial cell migration	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of nitric oxide biosynthetic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
bone resorption	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to ethanol	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
negative regulation of myeloid cell differentiation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of translation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of angiogenesis	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of protein kinase activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of JNK cascade	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein autophosphorylation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
focal adhesion assembly	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of synaptic plasticity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of release of sequestered calcium ion into cytosol	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to cAMP	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
response to calcium ion	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
long-term synaptic potentiation	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
long-term synaptic depression	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein-containing complex assembly	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
chemokine-mediated signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cellular response to retinoic acid	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cellular response to fluid shear stress	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
endothelin receptor signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of postsynaptic density assembly	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
postsynaptic modulation of chemical synaptic transmission	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
regulation of ubiquitin-dependent protein catabolic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of ubiquitin-dependent protein catabolic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of excitatory postsynaptic potential	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of B cell chemotaxis	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
apoptotic process	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
cell population proliferation	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
hemopoiesis	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
positive regulation of apoptotic process	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
protein autophosphorylation	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
neural precursor cell proliferation	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
protein phosphorylation	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
mitotic sister chromatid segregation	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
DNA repair	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
sister chromatid cohesion	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
mitotic sister chromatid cohesion	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
response to radiation	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
establishment of mitotic sister chromatid cohesion	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
establishment of meiotic sister chromatid cohesion	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
somatic stem cell population maintenance	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
cell division	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
meiotic cell cycle	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
response to DNA damage checkpoint signaling	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
mitotic spindle assembly	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
double-strand break repair via homologous recombination	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
chromatin remodeling	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
negative regulation of gene expression	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
regulation of cell fate specification	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
negative regulation of DNA-templated transcription	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
positive regulation of DNA-templated transcription	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
regulation of synapse assembly	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
terminal button organization	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
regulation of stem cell differentiation	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
very long-chain fatty acid metabolic process	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
generation of precursor metabolites and energy	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
lipid metabolic process	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
prostaglandin metabolic process	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
spermatogenesis	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
fatty acid catabolic process	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
fatty acid oxidation	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
fatty acid beta-oxidation using acyl-CoA oxidase	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
hydrogen peroxide biosynthetic process	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
very long-chain fatty acid beta-oxidation	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
lipid homeostasis	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
DNA damage checkpoint signaling	Serine/threonine-protein kinase 38	Homo sapiens (human)
chromatin organization	Serine/threonine-protein kinase 38	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 38	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase 38	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase 38	Homo sapiens (human)
protein modification process	Serine/threonine-protein kinase 38	Homo sapiens (human)
negative regulation of MAP kinase activity	Serine/threonine-protein kinase 38	Homo sapiens (human)
postsynapse organization	Serine/threonine-protein kinase 38	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase 38	Homo sapiens (human)
neural crest cell migration	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of protein phosphorylation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
signal transduction	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
epidermal growth factor receptor signaling pathway	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
nervous system development	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
synapse assembly	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
heart development	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
lactation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of cell population proliferation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
negative regulation of cell population proliferation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
embryonic pattern specification	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cell migration	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
central nervous system morphogenesis	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
olfactory bulb interneuron differentiation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
regulation of cell migration	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
ERBB4 signaling pathway	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
ERBB2-ERBB4 signaling pathway	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
ERBB4-ERBB4 signaling pathway	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
mitochondrial fragmentation involved in apoptotic process	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cell fate commitment	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of DNA-templated transcription	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of receptor signaling pathway via JAK-STAT	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
protein autophosphorylation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
mammary gland epithelial cell differentiation	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
mammary gland alveolus development	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cardiac muscle tissue regeneration	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cellular response to epidermal growth factor stimulus	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
establishment of planar polarity involved in nephron morphogenesis	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
neurotransmitter receptor localization to postsynaptic specialization membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of protein localization to cell surface	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
negative regulation of apoptotic process	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of kinase activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
multicellular organism development	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
neurogenesis	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
positive regulation of protein phosphorylation	Ephrin type-A receptor 7	Homo sapiens (human)
brain development	Ephrin type-A receptor 7	Homo sapiens (human)
phosphorylation	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of cell-cell adhesion	Ephrin type-A receptor 7	Homo sapiens (human)
retinal ganglion cell axon guidance	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of protein autophosphorylation	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ephrin type-A receptor 7	Homo sapiens (human)
positive regulation of neuron apoptotic process	Ephrin type-A receptor 7	Homo sapiens (human)
ephrin receptor signaling pathway	Ephrin type-A receptor 7	Homo sapiens (human)
negative regulation of collateral sprouting	Ephrin type-A receptor 7	Homo sapiens (human)
branching morphogenesis of a nerve	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of peptidyl-tyrosine phosphorylation	Ephrin type-A receptor 7	Homo sapiens (human)
modulation of chemical synaptic transmission	Ephrin type-A receptor 7	Homo sapiens (human)
negative chemotaxis	Ephrin type-A receptor 7	Homo sapiens (human)
neuron apoptotic process	Ephrin type-A receptor 7	Homo sapiens (human)
negative regulation of synapse assembly	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of ERK1 and ERK2 cascade	Ephrin type-A receptor 7	Homo sapiens (human)
nephric duct morphogenesis	Ephrin type-A receptor 7	Homo sapiens (human)
regulation of postsynapse organization	Ephrin type-A receptor 7	Homo sapiens (human)
axon guidance	Ephrin type-A receptor 7	Homo sapiens (human)
protein phosphorylation	Ephrin type-A receptor 7	Homo sapiens (human)
cholesterol biosynthetic process	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process	Delta(24)-sterol reductase	Homo sapiens (human)
Ras protein signal transduction	Delta(24)-sterol reductase	Homo sapiens (human)
protein localization	Delta(24)-sterol reductase	Homo sapiens (human)
negative regulation of cell population proliferation	Delta(24)-sterol reductase	Homo sapiens (human)
response to hormone	Delta(24)-sterol reductase	Homo sapiens (human)
tissue development	Delta(24)-sterol reductase	Homo sapiens (human)
male genitalia development	Delta(24)-sterol reductase	Homo sapiens (human)
plasminogen activation	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process via desmosterol	Delta(24)-sterol reductase	Homo sapiens (human)
cholesterol biosynthetic process via lathosterol	Delta(24)-sterol reductase	Homo sapiens (human)
amyloid precursor protein catabolic process	Delta(24)-sterol reductase	Homo sapiens (human)
skin development	Delta(24)-sterol reductase	Homo sapiens (human)
membrane organization	Delta(24)-sterol reductase	Homo sapiens (human)
steroid metabolic process	Delta(24)-sterol reductase	Homo sapiens (human)
protein phosphorylation	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
signal transduction	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
chemical synaptic transmission	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
positive regulation of cell growth	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
negative regulation of TOR signaling	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
intracellular signal transduction	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
negative regulation of apoptotic process	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
regulation of translation in response to stress	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
positive regulation of cell differentiation	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
hepatocyte proliferation	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
positive regulation of hepatic stellate cell activation	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
protein phosphorylation	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
smooth muscle contraction	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
tonic smooth muscle contraction	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
positive regulation of cell migration	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
bleb assembly	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
positive regulation of calcium ion transport	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
aorta smooth muscle tissue morphogenesis	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cellular hypotonic response	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
positive regulation of wound healing	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
positive regulation of erythrocyte differentiation	Mitogen-activated protein kinase 11	Homo sapiens (human)
osteoblast differentiation	Mitogen-activated protein kinase 11	Homo sapiens (human)
positive regulation of gene expression	Mitogen-activated protein kinase 11	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Mitogen-activated protein kinase 11	Homo sapiens (human)
positive regulation of interleukin-12 production	Mitogen-activated protein kinase 11	Homo sapiens (human)
p38MAPK cascade	Mitogen-activated protein kinase 11	Homo sapiens (human)
positive regulation of muscle cell differentiation	Mitogen-activated protein kinase 11	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 11	Homo sapiens (human)
cardiac muscle cell proliferation	Mitogen-activated protein kinase 11	Homo sapiens (human)
negative regulation of cardiac muscle cell proliferation	Mitogen-activated protein kinase 11	Homo sapiens (human)
bone development	Mitogen-activated protein kinase 11	Homo sapiens (human)
cellular response to interleukin-1	Mitogen-activated protein kinase 11	Homo sapiens (human)
cellular response to UV-B	Mitogen-activated protein kinase 11	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 11	Homo sapiens (human)
cellular response to virus	Mitogen-activated protein kinase 11	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 11	Homo sapiens (human)
G1 to G0 transition	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase STK11	Homo sapiens (human)
tissue homeostasis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
vasculature development	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein dephosphorylation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
autophagy	Serine/threonine-protein kinase STK11	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase STK11	Homo sapiens (human)
spermatogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
axonogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of cell population proliferation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
response to ionizing radiation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of autophagy	Serine/threonine-protein kinase STK11	Homo sapiens (human)
response to activity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
establishment of cell polarity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of cell growth	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of transforming growth factor beta receptor signaling pathway	Serine/threonine-protein kinase STK11	Homo sapiens (human)
activation of protein kinase activity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
response to glucagon	Serine/threonine-protein kinase STK11	Homo sapiens (human)
response to lipid	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein localization to nucleus	Serine/threonine-protein kinase STK11	Homo sapiens (human)
glucose homeostasis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
anoikis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive thymic T cell selection	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of gluconeogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of dendrite morphogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of axonogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
T cell receptor signaling pathway	Serine/threonine-protein kinase STK11	Homo sapiens (human)
Golgi localization	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of cell cycle	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Serine/threonine-protein kinase STK11	Homo sapiens (human)
epithelial cell proliferation involved in prostate gland development	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of epithelial cell proliferation involved in prostate gland development	Serine/threonine-protein kinase STK11	Homo sapiens (human)
cellular response to UV-B	Serine/threonine-protein kinase STK11	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Serine/threonine-protein kinase STK11	Homo sapiens (human)
response to thyroid hormone	Serine/threonine-protein kinase STK11	Homo sapiens (human)
dendrite extension	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of protein localization to nucleus	Serine/threonine-protein kinase STK11	Homo sapiens (human)
positive regulation of vesicle transport along microtubule	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Serine/threonine-protein kinase STK11	Homo sapiens (human)
negative regulation of TORC1 signaling	Serine/threonine-protein kinase STK11	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase STK11	Homo sapiens (human)
regulation of Wnt signaling pathway	Serine/threonine-protein kinase STK11	Homo sapiens (human)
B cell homeostasis	Serine/threonine-protein kinase N1	Homo sapiens (human)
B cell apoptotic process	Serine/threonine-protein kinase N1	Homo sapiens (human)
negative regulation of protein phosphorylation	Serine/threonine-protein kinase N1	Homo sapiens (human)
regulation of germinal center formation	Serine/threonine-protein kinase N1	Homo sapiens (human)
regulation of immunoglobulin production	Serine/threonine-protein kinase N1	Homo sapiens (human)
renal system process	Serine/threonine-protein kinase N1	Homo sapiens (human)
chromatin remodeling	Serine/threonine-protein kinase N1	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase N1	Homo sapiens (human)
hyperosmotic response	Serine/threonine-protein kinase N1	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase N1	Homo sapiens (human)
epithelial cell migration	Serine/threonine-protein kinase N1	Homo sapiens (human)
negative regulation of B cell proliferation	Serine/threonine-protein kinase N1	Homo sapiens (human)
post-translational protein modification	Serine/threonine-protein kinase N1	Homo sapiens (human)
positive regulation of DNA-templated transcription	Serine/threonine-protein kinase N1	Homo sapiens (human)
spleen development	Serine/threonine-protein kinase N1	Homo sapiens (human)
regulation of androgen receptor signaling pathway	Serine/threonine-protein kinase N1	Homo sapiens (human)
regulation of cell motility	Serine/threonine-protein kinase N1	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase N1	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase N2	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase N2	Homo sapiens (human)
cell adhesion	Serine/threonine-protein kinase N2	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase N2	Homo sapiens (human)
epithelial cell migration	Serine/threonine-protein kinase N2	Homo sapiens (human)
cell projection organization	Serine/threonine-protein kinase N2	Homo sapiens (human)
positive regulation of cytokinesis	Serine/threonine-protein kinase N2	Homo sapiens (human)
apical junction assembly	Serine/threonine-protein kinase N2	Homo sapiens (human)
positive regulation of viral genome replication	Serine/threonine-protein kinase N2	Homo sapiens (human)
positive regulation of mitotic cell cycle	Serine/threonine-protein kinase N2	Homo sapiens (human)
cell division	Serine/threonine-protein kinase N2	Homo sapiens (human)
regulation of cell motility	Serine/threonine-protein kinase N2	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase N2	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase N2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to lipopolysaccharide	Mitogen-activated protein kinase 14	Homo sapiens (human)
DNA damage checkpoint signaling	Mitogen-activated protein kinase 14	Homo sapiens (human)
cell morphogenesis	Mitogen-activated protein kinase 14	Homo sapiens (human)
cartilage condensation	Mitogen-activated protein kinase 14	Homo sapiens (human)
angiogenesis	Mitogen-activated protein kinase 14	Homo sapiens (human)
osteoblast differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
placenta development	Mitogen-activated protein kinase 14	Homo sapiens (human)
response to dietary excess	Mitogen-activated protein kinase 14	Homo sapiens (human)
chondrocyte differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
negative regulation of inflammatory response to antigenic stimulus	Mitogen-activated protein kinase 14	Homo sapiens (human)
glucose metabolic process	Mitogen-activated protein kinase 14	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 14	Homo sapiens (human)
transcription by RNA polymerase II	Mitogen-activated protein kinase 14	Homo sapiens (human)
apoptotic process	Mitogen-activated protein kinase 14	Homo sapiens (human)
chemotaxis	Mitogen-activated protein kinase 14	Homo sapiens (human)
signal transduction	Mitogen-activated protein kinase 14	Homo sapiens (human)
cell surface receptor signaling pathway	Mitogen-activated protein kinase 14	Homo sapiens (human)
cell surface receptor protein serine/threonine kinase signaling pathway	Mitogen-activated protein kinase 14	Homo sapiens (human)
skeletal muscle tissue development	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of gene expression	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of myotube differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase 14	Homo sapiens (human)
fatty acid oxidation	Mitogen-activated protein kinase 14	Homo sapiens (human)
platelet activation	Mitogen-activated protein kinase 14	Homo sapiens (human)
regulation of ossification	Mitogen-activated protein kinase 14	Homo sapiens (human)
osteoclast differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of cyclase activity	Mitogen-activated protein kinase 14	Homo sapiens (human)
lipopolysaccharide-mediated signaling pathway	Mitogen-activated protein kinase 14	Homo sapiens (human)
response to muramyl dipeptide	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of interleukin-12 production	Mitogen-activated protein kinase 14	Homo sapiens (human)
response to insulin	Mitogen-activated protein kinase 14	Homo sapiens (human)
negative regulation of hippo signaling	Mitogen-activated protein kinase 14	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Mitogen-activated protein kinase 14	Homo sapiens (human)
response to muscle stretch	Mitogen-activated protein kinase 14	Homo sapiens (human)
p38MAPK cascade	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of protein import into nucleus	Mitogen-activated protein kinase 14	Homo sapiens (human)
signal transduction in response to DNA damage	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of erythrocyte differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of myoblast differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Mitogen-activated protein kinase 14	Homo sapiens (human)
glucose import	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of glucose import	Mitogen-activated protein kinase 14	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Mitogen-activated protein kinase 14	Homo sapiens (human)
stem cell differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
striated muscle cell differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of muscle cell differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of cardiac muscle cell proliferation	Mitogen-activated protein kinase 14	Homo sapiens (human)
bone development	Mitogen-activated protein kinase 14	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to lipoteichoic acid	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to tumor necrosis factor	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to ionizing radiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to UV-B	Mitogen-activated protein kinase 14	Homo sapiens (human)
negative regulation of canonical Wnt signaling pathway	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of brown fat cell differentiation	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase 14	Homo sapiens (human)
stress-induced premature senescence	Mitogen-activated protein kinase 14	Homo sapiens (human)
cellular response to virus	Mitogen-activated protein kinase 14	Homo sapiens (human)
regulation of synaptic membrane adhesion	Mitogen-activated protein kinase 14	Homo sapiens (human)
regulation of cytokine production involved in inflammatory response	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of myoblast fusion	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Mitogen-activated protein kinase 14	Homo sapiens (human)
positive regulation of myeloid dendritic cell cytokine production	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
adaptive immune response	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
protein phosphorylation	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
inflammatory response	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
signal transduction	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
long-term memory	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
regulation of T cell differentiation in thymus	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
myeloid dendritic cell differentiation	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
regulation of osteoclast differentiation	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
positive regulation of DNA-templated transcription	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
protein autophosphorylation	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
peptidyl-serine phosphorylation	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
intracellular signal transduction	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
microtubule-based process	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
positive regulation of JUN kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
positive regulation of neuron apoptotic process	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
cell cycle G1/S phase transition	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
positive regulation of JNK cascade	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein autophosphorylation	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
positive regulation of apoptotic process	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
MAPK cascade	MAP kinase-activated protein kinase 3	Homo sapiens (human)
toll-like receptor signaling pathway	MAP kinase-activated protein kinase 3	Homo sapiens (human)
signal transduction	MAP kinase-activated protein kinase 3	Homo sapiens (human)
peptidyl-serine phosphorylation	MAP kinase-activated protein kinase 3	Homo sapiens (human)
response to lipopolysaccharide	MAP kinase-activated protein kinase 3	Homo sapiens (human)
response to cytokine	MAP kinase-activated protein kinase 3	Homo sapiens (human)
macropinocytosis	MAP kinase-activated protein kinase 3	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	MAP kinase-activated protein kinase 3	Homo sapiens (human)
intracellular signal transduction	MAP kinase-activated protein kinase 3	Homo sapiens (human)
protein autophosphorylation	MAP kinase-activated protein kinase 3	Homo sapiens (human)
ossification	Discoidin domain-containing receptor 2	Homo sapiens (human)
endochondral bone growth	Discoidin domain-containing receptor 2	Homo sapiens (human)
cell adhesion	Discoidin domain-containing receptor 2	Homo sapiens (human)
signal transduction	Discoidin domain-containing receptor 2	Homo sapiens (human)
regulation of extracellular matrix disassembly	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of fibroblast migration	Discoidin domain-containing receptor 2	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Discoidin domain-containing receptor 2	Homo sapiens (human)
collagen fibril organization	Discoidin domain-containing receptor 2	Homo sapiens (human)
regulation of bone mineralization	Discoidin domain-containing receptor 2	Homo sapiens (human)
biomineral tissue development	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of collagen biosynthetic process	Discoidin domain-containing receptor 2	Homo sapiens (human)
regulation of tissue remodeling	Discoidin domain-containing receptor 2	Homo sapiens (human)
chondrocyte proliferation	Discoidin domain-containing receptor 2	Homo sapiens (human)
response to muscle stretch	Discoidin domain-containing receptor 2	Homo sapiens (human)
collagen-activated tyrosine kinase receptor signaling pathway	Discoidin domain-containing receptor 2	Homo sapiens (human)
negative regulation of apoptotic process	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of osteoblast differentiation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of protein kinase activity	Discoidin domain-containing receptor 2	Homo sapiens (human)
protein autophosphorylation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of fibroblast proliferation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Discoidin domain-containing receptor 2	Homo sapiens (human)
cellular response to hypoxia	Discoidin domain-containing receptor 2	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of extracellular matrix disassembly	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of wound healing	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycle	Discoidin domain-containing receptor 2	Homo sapiens (human)
negative regulation of hydrogen peroxide-mediated programmed cell death	Discoidin domain-containing receptor 2	Homo sapiens (human)
cellular response to angiotensin	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell migration	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of hepatic stellate cell proliferation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of hepatic stellate cell activation	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of neuron projection development	Discoidin domain-containing receptor 2	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Discoidin domain-containing receptor 2	Homo sapiens (human)
multicellular organism development	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of kinase activity	Discoidin domain-containing receptor 2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Discoidin domain-containing receptor 2	Homo sapiens (human)
protein phosphorylation	AP2-associated protein kinase 1	Homo sapiens (human)
regulation of protein localization	AP2-associated protein kinase 1	Homo sapiens (human)
positive regulation of Notch signaling pathway	AP2-associated protein kinase 1	Homo sapiens (human)
protein stabilization	AP2-associated protein kinase 1	Homo sapiens (human)
membrane organization	AP2-associated protein kinase 1	Homo sapiens (human)
presynaptic endocytosis	AP2-associated protein kinase 1	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	AP2-associated protein kinase 1	Homo sapiens (human)
regulation of vascular permeability involved in acute inflammatory response	Myosin light chain kinase 3	Homo sapiens (human)
protein phosphorylation	Myosin light chain kinase 3	Homo sapiens (human)
sarcomere organization	Myosin light chain kinase 3	Homo sapiens (human)
sarcomerogenesis	Myosin light chain kinase 3	Homo sapiens (human)
cardiac myofibril assembly	Myosin light chain kinase 3	Homo sapiens (human)
positive regulation of sarcomere organization	Myosin light chain kinase 3	Homo sapiens (human)
cellular response to interleukin-1	Myosin light chain kinase 3	Homo sapiens (human)
biological_process	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
cellular response to heat	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
protein stabilization	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
protein folding	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cell migration	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
actin cytoskeleton organization	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
actomyosin structure organization	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
actin cytoskeleton organization	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
actomyosin structure organization	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
fatty acid beta-oxidation	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
fatty acid beta-oxidation using acyl-CoA dehydrogenase	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase N3	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase N3	Homo sapiens (human)
epithelial cell migration	Serine/threonine-protein kinase N3	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase N3	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase N3	Homo sapiens (human)
autophagy	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
smoothened signaling pathway	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
negative regulation of smoothened signaling pathway	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
positive regulation of smoothened signaling pathway	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
fibroblast activation	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
cellular senescence	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
reticulophagy	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
piecemeal microautophagy of the nucleus	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
response to starvation	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
autophagosome assembly	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
autophagy of mitochondrion	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
regulation of autophagy	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
mRNA processing	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
rRNA catabolic process	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
apoptotic chromosome condensation	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
response to endoplasmic reticulum stress	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
negative regulation of DNA-templated transcription	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
IRE1-mediated unfolded protein response	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
autophagy of mitochondrion	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
neuron migration	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
positive regulation of neuron projection development	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
Wnt signaling pathway	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
establishment of cell polarity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
activation of protein kinase activity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
establishment or maintenance of epithelial cell apical/basal polarity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
regulation of axonogenesis	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
regulation of cytoskeleton organization	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
mitochondrion localization	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
axon development	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
establishment or maintenance of cell polarity regulating cell shape	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
regulation of microtubule binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
microtubule cytoskeleton organization	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
central nervous system development	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
DNA duplex unwinding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
mitochondrial large ribosomal subunit assembly	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
microtubule cytoskeleton organization	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
DNA repair	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
negative regulation of microtubule depolymerization	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
mitotic G2 DNA damage checkpoint signaling	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
phosphorylation	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
central nervous system neuron development	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
positive regulation of stress-activated MAPK cascade	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
regulation of actin cytoskeleton organization	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
positive regulation of JNK cascade	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
regulation of cytoskeleton organization	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
neuron cellular homeostasis	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
regulation of microtubule cytoskeleton organization	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
execution phase of apoptosis	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
positive regulation of protein acetylation	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein phosphorylation	STE20-related kinase adapter protein alpha	Homo sapiens (human)
G1 to G0 transition	STE20-related kinase adapter protein alpha	Homo sapiens (human)
protein export from nucleus	STE20-related kinase adapter protein alpha	Homo sapiens (human)
activation of protein kinase activity	STE20-related kinase adapter protein alpha	Homo sapiens (human)
skeletal muscle contraction	Myosin-14	Homo sapiens (human)
mitochondrion organization	Myosin-14	Homo sapiens (human)
skeletal muscle tissue development	Myosin-14	Homo sapiens (human)
sensory perception of sound	Myosin-14	Homo sapiens (human)
regulation of cell shape	Myosin-14	Homo sapiens (human)
neuronal action potential	Myosin-14	Homo sapiens (human)
actin filament-based movement	Myosin-14	Homo sapiens (human)
actomyosin structure organization	Myosin-14	Homo sapiens (human)
vocalization behavior	Myosin-14	Homo sapiens (human)
negative regulation of mitochondrial fusion	AarF domain-containing protein kinase 1	Homo sapiens (human)
positive regulation of cristae formation	AarF domain-containing protein kinase 1	Homo sapiens (human)
mitochondrion organization	AarF domain-containing protein kinase 1	Homo sapiens (human)
lipid homeostasis	AarF domain-containing protein kinase 1	Homo sapiens (human)
protein localization	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
regulation of apoptotic process	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
U2-type prespliceosome assembly	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
response to UV	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
response to tumor necrosis factor	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
MAPK cascade	MAP kinase-activated protein kinase 5	Homo sapiens (human)
regulation of translation	MAP kinase-activated protein kinase 5	Homo sapiens (human)
signal transduction	MAP kinase-activated protein kinase 5	Homo sapiens (human)
Ras protein signal transduction	MAP kinase-activated protein kinase 5	Homo sapiens (human)
negative regulation of TOR signaling	MAP kinase-activated protein kinase 5	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	MAP kinase-activated protein kinase 5	Homo sapiens (human)
protein autophosphorylation	MAP kinase-activated protein kinase 5	Homo sapiens (human)
positive regulation of telomerase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
positive regulation of dendritic spine development	MAP kinase-activated protein kinase 5	Homo sapiens (human)
cellular senescence	MAP kinase-activated protein kinase 5	Homo sapiens (human)
stress-induced premature senescence	MAP kinase-activated protein kinase 5	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	MAP kinase-activated protein kinase 5	Homo sapiens (human)
positive regulation of telomere capping	MAP kinase-activated protein kinase 5	Homo sapiens (human)
peptidyl-serine phosphorylation	MAP kinase-activated protein kinase 5	Homo sapiens (human)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
translational termination	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
translation	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
microvillus assembly	Misshapen-like kinase 1	Homo sapiens (human)
regulation of cell-matrix adhesion	Misshapen-like kinase 1	Homo sapiens (human)
protein phosphorylation	Misshapen-like kinase 1	Homo sapiens (human)
JNK cascade	Misshapen-like kinase 1	Homo sapiens (human)
chemical synaptic transmission	Misshapen-like kinase 1	Homo sapiens (human)
brain development	Misshapen-like kinase 1	Homo sapiens (human)
regulation of cell-cell adhesion	Misshapen-like kinase 1	Homo sapiens (human)
actin cytoskeleton organization	Misshapen-like kinase 1	Homo sapiens (human)
regulation of cell migration	Misshapen-like kinase 1	Homo sapiens (human)
positive regulation of JNK cascade	Misshapen-like kinase 1	Homo sapiens (human)
protein autophosphorylation	Misshapen-like kinase 1	Homo sapiens (human)
dendrite morphogenesis	Misshapen-like kinase 1	Homo sapiens (human)
positive regulation of p38MAPK cascade	Misshapen-like kinase 1	Homo sapiens (human)
regulation of AMPA receptor activity	Misshapen-like kinase 1	Homo sapiens (human)
MAPK cascade	Misshapen-like kinase 1	Homo sapiens (human)
neuron projection morphogenesis	Misshapen-like kinase 1	Homo sapiens (human)
regulation of MAPK cascade	Misshapen-like kinase 1	Homo sapiens (human)
protein phosphorylation	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
ubiquinone biosynthetic process	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
phosphorylation	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
regulation of autophagy	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
positive regulation of autophagosome assembly	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase 15	Homo sapiens (human)
regulation of COPII vesicle coating	Mitogen-activated protein kinase 15	Homo sapiens (human)
DNA damage response	Mitogen-activated protein kinase 15	Homo sapiens (human)
endoplasmic reticulum organization	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of cell population proliferation	Mitogen-activated protein kinase 15	Homo sapiens (human)
regulation of autophagy	Mitogen-activated protein kinase 15	Homo sapiens (human)
negative regulation of cell migration	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein autophosphorylation	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of telomerase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
dopamine uptake	Mitogen-activated protein kinase 15	Homo sapiens (human)
regulation of cilium assembly	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of telomere capping	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein localization to ciliary transition zone	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of metaphase/anaphase transition of meiosis I	Mitogen-activated protein kinase 15	Homo sapiens (human)
positive regulation of spindle assembly	Mitogen-activated protein kinase 15	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase 15	Homo sapiens (human)
mitotic cell cycle	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
regulation of mitotic cell cycle	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
cell division	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
regulation of mitotic cell cycle	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
cellular response to potassium ion	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
spindle assembly	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
positive regulation of telomerase activity	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
positive regulation of telomere capping	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 7	Homo sapiens (human)
vasculogenesis	Histone deacetylase 7	Homo sapiens (human)
chromatin remodeling	Histone deacetylase 7	Homo sapiens (human)
protein deacetylation	Histone deacetylase 7	Homo sapiens (human)
cell-cell junction assembly	Histone deacetylase 7	Homo sapiens (human)
protein sumoylation	Histone deacetylase 7	Homo sapiens (human)
negative regulation of interleukin-2 production	Histone deacetylase 7	Homo sapiens (human)
negative regulation of osteoblast differentiation	Histone deacetylase 7	Homo sapiens (human)
regulation of mRNA processing	Histone deacetylase 7	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Histone deacetylase 7	Homo sapiens (human)
negative regulation of non-canonical NF-kappaB signal transduction	Histone deacetylase 7	Homo sapiens (human)
spliceosomal complex assembly	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
positive regulation of myeloid dendritic cell cytokine production	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
double-strand break repair	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
tRNA splicing, via endonucleolytic cleavage and ligation	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
regulation of translational initiation	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
DNA duplex unwinding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
response to exogenous dsRNA	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
innate immune response	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
defense response to virus	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
nucleic acid metabolic process	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
protein localization to cytoplasmic stress granule	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
inositol phosphate metabolic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
negative regulation of cold-induced thermogenesis	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol phosphate biosynthetic process	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
positive regulation of signaling receptor activity	Histone deacetylase 2	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 2	Homo sapiens (human)
response to amphetamine	Histone deacetylase 2	Homo sapiens (human)
cardiac muscle hypertrophy	Histone deacetylase 2	Homo sapiens (human)
chromatin remodeling	Histone deacetylase 2	Homo sapiens (human)
positive regulation of cell population proliferation	Histone deacetylase 2	Homo sapiens (human)
response to xenobiotic stimulus	Histone deacetylase 2	Homo sapiens (human)
epidermal cell differentiation	Histone deacetylase 2	Homo sapiens (human)
positive regulation of epithelial to mesenchymal transition	Histone deacetylase 2	Homo sapiens (human)
negative regulation of transcription by competitive promoter binding	Histone deacetylase 2	Homo sapiens (human)
negative regulation of neuron projection development	Histone deacetylase 2	Homo sapiens (human)
dendrite development	Histone deacetylase 2	Homo sapiens (human)
negative regulation of cell migration	Histone deacetylase 2	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Histone deacetylase 2	Homo sapiens (human)
response to caffeine	Histone deacetylase 2	Homo sapiens (human)
heterochromatin formation	Histone deacetylase 2	Homo sapiens (human)
response to lipopolysaccharide	Histone deacetylase 2	Homo sapiens (human)
positive regulation of interleukin-1 production	Histone deacetylase 2	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Histone deacetylase 2	Homo sapiens (human)
circadian regulation of gene expression	Histone deacetylase 2	Homo sapiens (human)
positive regulation of collagen biosynthetic process	Histone deacetylase 2	Homo sapiens (human)
cellular response to heat	Histone deacetylase 2	Homo sapiens (human)
response to nicotine	Histone deacetylase 2	Homo sapiens (human)
protein modification process	Histone deacetylase 2	Homo sapiens (human)
response to cocaine	Histone deacetylase 2	Homo sapiens (human)
odontogenesis of dentin-containing tooth	Histone deacetylase 2	Homo sapiens (human)
positive regulation of tyrosine phosphorylation of STAT protein	Histone deacetylase 2	Homo sapiens (human)
regulation of cell fate specification	Histone deacetylase 2	Homo sapiens (human)
embryonic digit morphogenesis	Histone deacetylase 2	Homo sapiens (human)
negative regulation of apoptotic process	Histone deacetylase 2	Homo sapiens (human)
negative regulation of DNA-binding transcription factor activity	Histone deacetylase 2	Homo sapiens (human)
negative regulation of MHC class II biosynthetic process	Histone deacetylase 2	Homo sapiens (human)
positive regulation of proteolysis	Histone deacetylase 2	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Histone deacetylase 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Histone deacetylase 2	Homo sapiens (human)
behavioral response to ethanol	Histone deacetylase 2	Homo sapiens (human)
positive regulation of oligodendrocyte differentiation	Histone deacetylase 2	Homo sapiens (human)
response to hyperoxia	Histone deacetylase 2	Homo sapiens (human)
hair follicle placode formation	Histone deacetylase 2	Homo sapiens (human)
negative regulation of dendritic spine development	Histone deacetylase 2	Homo sapiens (human)
eyelid development in camera-type eye	Histone deacetylase 2	Homo sapiens (human)
fungiform papilla formation	Histone deacetylase 2	Homo sapiens (human)
cellular response to hydrogen peroxide	Histone deacetylase 2	Homo sapiens (human)
cellular response to retinoic acid	Histone deacetylase 2	Homo sapiens (human)
cellular response to transforming growth factor beta stimulus	Histone deacetylase 2	Homo sapiens (human)
positive regulation of male mating behavior	Histone deacetylase 2	Homo sapiens (human)
negative regulation of stem cell population maintenance	Histone deacetylase 2	Homo sapiens (human)
positive regulation of stem cell population maintenance	Histone deacetylase 2	Homo sapiens (human)
cellular response to dopamine	Histone deacetylase 2	Homo sapiens (human)
response to amyloid-beta	Histone deacetylase 2	Homo sapiens (human)
regulation of stem cell differentiation	Histone deacetylase 2	Homo sapiens (human)
negative regulation of peptidyl-lysine acetylation	Histone deacetylase 2	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
cell population proliferation	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
positive regulation of MAPK cascade	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
protein autophosphorylation	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
cellular response to phorbol 13-acetate 12-myristate	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Polyamine deacetylase HDAC10	Homo sapiens (human)
DNA repair	Polyamine deacetylase HDAC10	Homo sapiens (human)
chromatin organization	Polyamine deacetylase HDAC10	Homo sapiens (human)
regulation of DNA-templated transcription	Polyamine deacetylase HDAC10	Homo sapiens (human)
macroautophagy	Polyamine deacetylase HDAC10	Homo sapiens (human)
positive regulation of mismatch repair	Polyamine deacetylase HDAC10	Homo sapiens (human)
homologous recombination	Polyamine deacetylase HDAC10	Homo sapiens (human)
negative regulation of DNA-templated transcription	Polyamine deacetylase HDAC10	Homo sapiens (human)
polyamine deacetylation	Polyamine deacetylase HDAC10	Homo sapiens (human)
spermidine deacetylation	Polyamine deacetylase HDAC10	Homo sapiens (human)
epigenetic regulation of gene expression	Polyamine deacetylase HDAC10	Homo sapiens (human)
chromatin organization	Histone deacetylase 11	Homo sapiens (human)
oligodendrocyte development	Histone deacetylase 11	Homo sapiens (human)
epigenetic regulation of gene expression	Histone deacetylase 11	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Aurora kinase B	Homo sapiens (human)
mitotic cell cycle	Aurora kinase B	Homo sapiens (human)
mitotic cytokinesis	Aurora kinase B	Homo sapiens (human)
negative regulation of B cell apoptotic process	Aurora kinase B	Homo sapiens (human)
protein phosphorylation	Aurora kinase B	Homo sapiens (human)
spindle organization	Aurora kinase B	Homo sapiens (human)
attachment of spindle microtubules to kinetochore	Aurora kinase B	Homo sapiens (human)
abscission	Aurora kinase B	Homo sapiens (human)
negative regulation of protein binding	Aurora kinase B	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Aurora kinase B	Homo sapiens (human)
negative regulation of cytokinesis	Aurora kinase B	Homo sapiens (human)
positive regulation of cytokinesis	Aurora kinase B	Homo sapiens (human)
protein localization to kinetochore	Aurora kinase B	Homo sapiens (human)
cellular response to UV	Aurora kinase B	Homo sapiens (human)
cleavage furrow formation	Aurora kinase B	Homo sapiens (human)
post-translational protein modification	Aurora kinase B	Homo sapiens (human)
cell cycle G2/M phase transition	Aurora kinase B	Homo sapiens (human)
mitotic cytokinesis checkpoint signaling	Aurora kinase B	Homo sapiens (human)
negative regulation of innate immune response	Aurora kinase B	Homo sapiens (human)
protein autophosphorylation	Aurora kinase B	Homo sapiens (human)
mitotic spindle midzone assembly	Aurora kinase B	Homo sapiens (human)
positive regulation of telomerase activity	Aurora kinase B	Homo sapiens (human)
regulation of chromosome segregation	Aurora kinase B	Homo sapiens (human)
positive regulation of mitotic sister chromatid segregation	Aurora kinase B	Homo sapiens (human)
positive regulation of mitotic cell cycle spindle assembly checkpoint	Aurora kinase B	Homo sapiens (human)
mitotic spindle assembly	Aurora kinase B	Homo sapiens (human)
negative regulation of cGAS/STING signaling pathway	Aurora kinase B	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	Aurora kinase B	Homo sapiens (human)
positive regulation of mitotic sister chromatid separation	Aurora kinase B	Homo sapiens (human)
positive regulation of attachment of mitotic spindle microtubules to kinetochore	Aurora kinase B	Homo sapiens (human)
positive regulation of mitotic cytokinesis	Aurora kinase B	Homo sapiens (human)
positive regulation of telomere capping	Aurora kinase B	Homo sapiens (human)
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	Aurora kinase B	Homo sapiens (human)
mitotic spindle organization	Aurora kinase B	Homo sapiens (human)
regulation of cytokinesis	Aurora kinase B	Homo sapiens (human)
microtubule cytoskeleton organization	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
positive regulation of cell cycle	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
microtubule cytoskeleton organization	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
microtubule bundle formation	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
protein phosphorylation	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
nervous system development	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
positive regulation of programmed cell death	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cilium organization	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
positive regulation of cilium assembly	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
regulation of centrosome cycle	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cell division	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assembly	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
positive regulation of protein localization to centrosome	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
intracellular signal transduction	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
peptidyl-serine phosphorylation	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
cell division	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
cilium assembly	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
MAPK cascade	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
positive regulation of protein phosphorylation	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein phosphorylation	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
calcium-mediated signaling	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
cellular response to reactive oxygen species	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
regulation of protein kinase activity	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein autophosphorylation	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
CAMKK-AMPK signaling cascade	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
positive regulation of autophagy of mitochondrion	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein phosphorylation	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
tRNA processing	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
regulation of signal transduction by p53 class mediator	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
tRNA threonylcarbamoyladenosine metabolic process	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
protein phosphorylation	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
spermatogenesis	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
actin cytoskeleton organization	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
focal adhesion assembly	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
regulation of cyclin-dependent protein serine/threonine kinase activity	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
G2/M transition of mitotic cell cycle	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
mitotic cell cycle	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
regulation of mitotic nuclear division	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
negative regulation of G2/M transition of mitotic cell cycle	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
protein phosphorylation	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
negative regulation of G2/MI transition of meiotic cell cycle	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
meiotic cell cycle	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
response to ischemia	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to oxidative stress	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular response to amino acid starvation	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
response to endoplasmic reticulum stress	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
neuron intrinsic apoptotic signaling pathway in response to oxidative stress	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
p38MAPK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of apoptotic process	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of JUN kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
innate immune response	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of myoblast differentiation	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of protein kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of DNA-templated transcription	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of JNK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
neuron apoptotic process	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular response to hydrogen peroxide	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular response to tumor necrosis factor	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
endothelial cell apoptotic process	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular senescence	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
apoptotic signaling pathway	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
programmed necrotic cell death	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of p38MAPK cascade	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular response to reactive nitrogen species	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferation	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cellular response to stress	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
protein autophosphorylation	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
blood vessel development	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
positive regulation of cell proliferation in bone marrow	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
positive regulation of p38MAPK cascade	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
negative regulation of cellular senescence	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
acute inflammatory response	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
phagocytosis	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
negative regulation of cell population proliferation	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
regulation of eIF2 alpha phosphorylation by heme	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
macrophage differentiation	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
negative regulation of translational initiation by iron	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
protoporphyrinogen IX metabolic process	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
protein autophosphorylation	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
negative regulation of hemoglobin biosynthetic process	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
establishment of localization in cell	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
multicellular organismal-level iron ion homeostasis	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
integrated stress response signaling	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
HRI-mediated signaling	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
positive regulation of mitophagy	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
response to iron ion starvation	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
regulation of translational initiation by eIF2 alpha phosphorylation	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 8	Homo sapiens (human)
chromatin organization	Histone deacetylase 8	Homo sapiens (human)
mitotic sister chromatid cohesion	Histone deacetylase 8	Homo sapiens (human)
negative regulation of protein ubiquitination	Histone deacetylase 8	Homo sapiens (human)
regulation of protein stability	Histone deacetylase 8	Homo sapiens (human)
regulation of telomere maintenance	Histone deacetylase 8	Homo sapiens (human)
epigenetic regulation of gene expression	Histone deacetylase 8	Homo sapiens (human)
regulation of cyclin-dependent protein serine/threonine kinase activity	Nucleolar GTP-binding protein 1	Homo sapiens (human)
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Nucleolar GTP-binding protein 1	Homo sapiens (human)
osteoblast differentiation	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of DNA replication	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of cell population proliferation	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of cell-cell adhesion	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of cell migration	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of protein ubiquitination	Nucleolar GTP-binding protein 1	Homo sapiens (human)
negative regulation of collagen binding	Nucleolar GTP-binding protein 1	Homo sapiens (human)
ribosomal large subunit biogenesis	Nucleolar GTP-binding protein 1	Homo sapiens (human)
protein stabilization	Nucleolar GTP-binding protein 1	Homo sapiens (human)
angiogenesis	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of endothelial cell proliferation	Serine/threonine-protein kinase D2	Homo sapiens (human)
adaptive immune response	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase D2	Homo sapiens (human)
cell adhesion	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of endothelial cell migration	Serine/threonine-protein kinase D2	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase D2	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase D2	Homo sapiens (human)
sphingolipid biosynthetic process	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of vascular endothelial growth factor receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of interleukin-2 production	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of interleukin-8 production	Serine/threonine-protein kinase D2	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase D2	Homo sapiens (human)
cellular response to vascular endothelial growth factor stimulus	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of fibroblast growth factor receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of angiogenesis	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of cell adhesion	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase D2	Homo sapiens (human)
vascular endothelial growth factor receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
T cell receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
endothelial tube morphogenesis	Serine/threonine-protein kinase D2	Homo sapiens (human)
regulation of T cell apoptotic process	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of DNA biosynthetic process	Serine/threonine-protein kinase D2	Homo sapiens (human)
positive regulation of endothelial cell chemotaxis	Serine/threonine-protein kinase D2	Homo sapiens (human)
phospholipase C-activating G protein-coupled receptor signaling pathway	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein phosphorylation	NUAK family SNF1-like kinase 2	Homo sapiens (human)
apoptotic process	NUAK family SNF1-like kinase 2	Homo sapiens (human)
actin cytoskeleton organization	NUAK family SNF1-like kinase 2	Homo sapiens (human)
protein localization to nucleus	NUAK family SNF1-like kinase 2	Homo sapiens (human)
regulation of hippo signaling	NUAK family SNF1-like kinase 2	Homo sapiens (human)
cellular response to glucose starvation	NUAK family SNF1-like kinase 2	Homo sapiens (human)
negative regulation of apoptotic process	NUAK family SNF1-like kinase 2	Homo sapiens (human)
rRNA modification	RNA cytidine acetyltransferase	Homo sapiens (human)
regulation of translation	RNA cytidine acetyltransferase	Homo sapiens (human)
protein acetylation	RNA cytidine acetyltransferase	Homo sapiens (human)
regulation of centrosome duplication	RNA cytidine acetyltransferase	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	RNA cytidine acetyltransferase	Homo sapiens (human)
ribosomal small subunit biogenesis	RNA cytidine acetyltransferase	Homo sapiens (human)
positive regulation of translation	RNA cytidine acetyltransferase	Homo sapiens (human)
tRNA acetylation	RNA cytidine acetyltransferase	Homo sapiens (human)
rRNA acetylation involved in maturation of SSU-rRNA	RNA cytidine acetyltransferase	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
regulation of insulin receptor signaling pathway	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
apoptotic process	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
regulation of cell migration	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
cytoplasmic microtubule organization	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
regulation of apoptotic process	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein autophosphorylation	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
regulation of focal adhesion assembly	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein phosphorylation	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
MAPK cascade	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
DNA repair	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
mitotic G2 DNA damage checkpoint signaling	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
positive regulation of stress-activated MAPK cascade	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
positive regulation of JUN kinase activity	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
negative regulation of JNK cascade	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
positive regulation of JNK cascade	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
regulation of MAPK cascade	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
neuron projection morphogenesis	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
dTTP catabolic process	dCTP pyrophosphatase 1	Homo sapiens (human)
dCTP catabolic process	dCTP pyrophosphatase 1	Homo sapiens (human)
nucleoside triphosphate catabolic process	dCTP pyrophosphatase 1	Homo sapiens (human)
DNA protection	dCTP pyrophosphatase 1	Homo sapiens (human)
regulation of RNA splicing	Dual specificity protein kinase CLK4	Homo sapiens (human)
peptidyl-tyrosine phosphorylation	Dual specificity protein kinase CLK4	Homo sapiens (human)
mitotic cell cycle	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule-based process	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
mitotic metaphase chromosome alignment	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
attachment of spindle microtubules to kinetochore	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
cell division	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule cytoskeleton organization	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
Wnt signaling pathway	Casein kinase I isoform gamma-1	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform gamma-1	Homo sapiens (human)
signal transduction	Casein kinase I isoform gamma-1	Homo sapiens (human)
endocytosis	Casein kinase I isoform gamma-1	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform gamma-1	Homo sapiens (human)
translation	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
phenylalanyl-tRNA aminoacylation	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
protein heterotetramerization	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
tRNA aminoacylation for protein translation	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
aminoacyl-tRNA metabolism involved in translational fidelity	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
isoleucyl-tRNA aminoacylation	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
mitochondrial translation	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
positive regulation of Notch signaling pathway	BMP-2-inducible protein kinase	Homo sapiens (human)
regulation of clathrin-dependent endocytosis	BMP-2-inducible protein kinase	Homo sapiens (human)
regulation of bone mineralization	BMP-2-inducible protein kinase	Homo sapiens (human)
ATP metabolic process	Obg-like ATPase 1	Homo sapiens (human)
ribosomal large subunit assembly	Midasin	Homo sapiens (human)
ribosomal large subunit export from nucleus	Midasin	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
neutrophil mediated immunity	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
MyD88-dependent toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
JNK cascade	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
toll-like receptor 9 signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
interleukin-33-mediated signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
innate immune response	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
positive regulation of smooth muscle cell proliferation	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
neutrophil migration	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
cytokine-mediated signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
Toll signaling pathway	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
cellular response to lipopolysaccharide	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
intracellular signal transduction	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
positive regulation of programmed cell death	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
GCN2-mediated signaling	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
pyroptosis	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
DNA damage checkpoint signaling	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
inflammatory response	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cytoskeleton organization	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
JNK cascade	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cell death	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cell differentiation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
stress-activated protein kinase signaling cascade	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
p38MAPK cascade	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
embryonic digit morphogenesis	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
positive regulation of apoptotic process	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein autophosphorylation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
stress-activated MAPK cascade	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
limb development	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cellular response to gamma radiation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cellular response to UV-B	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
positive regulation of mitotic DNA damage checkpoint	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
peptidyl-serine phosphorylation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
regulation of mitotic metaphase/anaphase transition	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
chromosome segregation	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
transcription by RNA polymerase II	Cyclin-dependent kinase 12	Homo sapiens (human)
mRNA processing	Cyclin-dependent kinase 12	Homo sapiens (human)
RNA splicing	Cyclin-dependent kinase 12	Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase II	Cyclin-dependent kinase 12	Homo sapiens (human)
regulation of MAP kinase activity	Cyclin-dependent kinase 12	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cyclin-dependent kinase 12	Homo sapiens (human)
protein autophosphorylation	Cyclin-dependent kinase 12	Homo sapiens (human)
regulation of cell cycle	Cyclin-dependent kinase 12	Homo sapiens (human)
negative regulation of stem cell differentiation	Cyclin-dependent kinase 12	Homo sapiens (human)
protein phosphorylation	Cyclin-dependent kinase 12	Homo sapiens (human)
aerobic respiration	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
negative regulation of cell growth	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrial respiratory chain complex I assembly	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
cellular response to interferon-beta	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
proton motive force-driven mitochondrial ATP synthesis	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
protein insertion into mitochondrial inner membrane	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
positive regulation of protein catabolic process	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
negative regulation of DNA-templated transcription	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
cellular response to retinoic acid	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
reactive oxygen species metabolic process	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
apoptotic signaling pathway	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
extrinsic apoptotic signaling pathway	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
positive regulation of execution phase of apoptosis	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase 26	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase 26	Homo sapiens (human)
cellular response to starvation	Serine/threonine-protein kinase 26	Homo sapiens (human)
microvillus assembly	Serine/threonine-protein kinase 26	Homo sapiens (human)
negative regulation of cell migration	Serine/threonine-protein kinase 26	Homo sapiens (human)
cellular response to oxidative stress	Serine/threonine-protein kinase 26	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase 26	Homo sapiens (human)
regulation of apoptotic process	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase 26	Homo sapiens (human)
tricarboxylic acid cycle	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinate metabolic process	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinyl-CoA pathway	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinyl-CoA catabolic process	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinyl-CoA metabolic process	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
MAPK cascade	Serine/threonine-protein kinase NLK	Homo sapiens (human)
regulation of DNA-templated transcription	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase NLK	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Serine/threonine-protein kinase NLK	Homo sapiens (human)
Wnt signaling pathway, calcium modulating pathway	Serine/threonine-protein kinase NLK	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase NLK	Homo sapiens (human)
negative regulation of Wnt signaling pathway	Serine/threonine-protein kinase NLK	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein stabilization	Serine/threonine-protein kinase NLK	Homo sapiens (human)
cellular response to osmotic stress	Serine/threonine-protein kinase NLK	Homo sapiens (human)
negative regulation of TORC1 signaling	Serine/threonine-protein kinase NLK	Homo sapiens (human)
positive regulation of receptor signaling pathway via STAT	Serine/threonine-protein kinase NLK	Homo sapiens (human)
polyamine deacetylation	Histone deacetylase 6	Homo sapiens (human)
spermidine deacetylation	Histone deacetylase 6	Homo sapiens (human)
positive regulation of signaling receptor activity	Histone deacetylase 6	Homo sapiens (human)
protein polyubiquitination	Histone deacetylase 6	Homo sapiens (human)
response to amphetamine	Histone deacetylase 6	Homo sapiens (human)
protein deacetylation	Histone deacetylase 6	Homo sapiens (human)
protein quality control for misfolded or incompletely synthesized proteins	Histone deacetylase 6	Homo sapiens (human)
intracellular protein transport	Histone deacetylase 6	Homo sapiens (human)
autophagy	Histone deacetylase 6	Homo sapiens (human)
actin filament organization	Histone deacetylase 6	Homo sapiens (human)
negative regulation of microtubule depolymerization	Histone deacetylase 6	Homo sapiens (human)
regulation of autophagy	Histone deacetylase 6	Homo sapiens (human)
positive regulation of epithelial cell migration	Histone deacetylase 6	Homo sapiens (human)
negative regulation of hydrogen peroxide metabolic process	Histone deacetylase 6	Homo sapiens (human)
regulation of macroautophagy	Histone deacetylase 6	Homo sapiens (human)
axonal transport of mitochondrion	Histone deacetylase 6	Homo sapiens (human)
negative regulation of protein-containing complex assembly	Histone deacetylase 6	Homo sapiens (human)
regulation of protein stability	Histone deacetylase 6	Homo sapiens (human)
protein destabilization	Histone deacetylase 6	Homo sapiens (human)
lysosome localization	Histone deacetylase 6	Homo sapiens (human)
protein-containing complex disassembly	Histone deacetylase 6	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Histone deacetylase 6	Homo sapiens (human)
cellular response to heat	Histone deacetylase 6	Homo sapiens (human)
peptidyl-lysine deacetylation	Histone deacetylase 6	Homo sapiens (human)
response to immobilization stress	Histone deacetylase 6	Homo sapiens (human)
cellular response to topologically incorrect protein	Histone deacetylase 6	Homo sapiens (human)
erythrocyte enucleation	Histone deacetylase 6	Homo sapiens (human)
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	Histone deacetylase 6	Homo sapiens (human)
negative regulation of protein-containing complex disassembly	Histone deacetylase 6	Homo sapiens (human)
regulation of fat cell differentiation	Histone deacetylase 6	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Histone deacetylase 6	Homo sapiens (human)
negative regulation of proteolysis	Histone deacetylase 6	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 6	Homo sapiens (human)
collateral sprouting	Histone deacetylase 6	Homo sapiens (human)
negative regulation of axon extension involved in axon guidance	Histone deacetylase 6	Homo sapiens (human)
positive regulation of dendrite morphogenesis	Histone deacetylase 6	Homo sapiens (human)
negative regulation of oxidoreductase activity	Histone deacetylase 6	Homo sapiens (human)
response to corticosterone	Histone deacetylase 6	Homo sapiens (human)
response to misfolded protein	Histone deacetylase 6	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Histone deacetylase 6	Homo sapiens (human)
cilium assembly	Histone deacetylase 6	Homo sapiens (human)
regulation of microtubule-based movement	Histone deacetylase 6	Homo sapiens (human)
regulation of androgen receptor signaling pathway	Histone deacetylase 6	Homo sapiens (human)
dendritic spine morphogenesis	Histone deacetylase 6	Homo sapiens (human)
cilium disassembly	Histone deacetylase 6	Homo sapiens (human)
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	Histone deacetylase 6	Homo sapiens (human)
regulation of establishment of protein localization	Histone deacetylase 6	Homo sapiens (human)
cellular response to hydrogen peroxide	Histone deacetylase 6	Homo sapiens (human)
aggresome assembly	Histone deacetylase 6	Homo sapiens (human)
polyubiquitinated misfolded protein transport	Histone deacetylase 6	Homo sapiens (human)
response to growth factor	Histone deacetylase 6	Homo sapiens (human)
cellular response to misfolded protein	Histone deacetylase 6	Homo sapiens (human)
cellular response to parathyroid hormone stimulus	Histone deacetylase 6	Homo sapiens (human)
response to dexamethasone	Histone deacetylase 6	Homo sapiens (human)
tubulin deacetylation	Histone deacetylase 6	Homo sapiens (human)
positive regulation of tubulin deacetylation	Histone deacetylase 6	Homo sapiens (human)
positive regulation of cellular response to oxidative stress	Histone deacetylase 6	Homo sapiens (human)
negative regulation of protein acetylation	Histone deacetylase 6	Homo sapiens (human)
regulation of autophagy of mitochondrion	Histone deacetylase 6	Homo sapiens (human)
positive regulation of cholangiocyte proliferation	Histone deacetylase 6	Homo sapiens (human)
negative regulation of aggrephagy	Histone deacetylase 6	Homo sapiens (human)
epigenetic regulation of gene expression	Histone deacetylase 6	Homo sapiens (human)
glycogen metabolic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
regulation of glycolytic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
negative regulation of protein kinase activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
fatty acid biosynthetic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
ATP biosynthetic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
positive regulation of peptidyl-threonine phosphorylation	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
sterol biosynthetic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
regulation of fatty acid metabolic process	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cellular response to nutrient levels	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
intracellular signal transduction	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
positive regulation of protein kinase activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
regulation of fatty acid oxidation	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
regulation of glucose import	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
regulation of catalytic activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
protein phosphorylation	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
activation of innate immune response	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
cytoplasmic pattern recognition receptor signaling pathway	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
inflammatory response	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
canonical NF-kappaB signal transduction	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
response to virus	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of autophagy	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
negative regulation of gene expression	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of macroautophagy	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
peptidyl-serine phosphorylation	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
regulation of type I interferon production	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of type I interferon production	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of interferon-alpha production	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of interferon-beta production	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylation	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
dendritic cell proliferation	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
innate immune response	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
defense response to Gram-positive bacterium	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
defense response to virus	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
type I interferon-mediated signaling pathway	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of type I interferon-mediated signaling pathway	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
antiviral innate immune response	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
cGAS/STING signaling pathway	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
negative regulation of TORC1 signaling	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of TORC1 signaling	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of xenophagy	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
macroautophagy	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
positive regulation of non-motile cilium assembly	Septin-9	Homo sapiens (human)
protein localization	Septin-9	Homo sapiens (human)
cytoskeleton-dependent cytokinesis	Septin-9	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
signal transduction	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
central nervous system development	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
negative regulation of embryonic development	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascade	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
negative regulation of mesoderm development	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
peptidyl-serine phosphorylation	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
positive regulation of protein phosphorylation	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein phosphorylation	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
cytoskeleton organization	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
response to organonitrogen compound	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
Wnt signaling pathway	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
microvillus assembly	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
actin cytoskeleton organization	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
intracellular signal transduction	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
positive regulation of JNK cascade	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein autophosphorylation	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
regulation of dendrite morphogenesis	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein localization to plasma membrane	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
neuron projection morphogenesis	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
regulation of MAPK cascade	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
MAPK cascade	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 9	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 9	Homo sapiens (human)
negative regulation of cytokine production	Histone deacetylase 9	Homo sapiens (human)
response to amphetamine	Histone deacetylase 9	Homo sapiens (human)
inflammatory response	Histone deacetylase 9	Homo sapiens (human)
heart development	Histone deacetylase 9	Homo sapiens (human)
neuron differentiation	Histone deacetylase 9	Homo sapiens (human)
B cell differentiation	Histone deacetylase 9	Homo sapiens (human)
cellular response to insulin stimulus	Histone deacetylase 9	Homo sapiens (human)
peptidyl-lysine deacetylation	Histone deacetylase 9	Homo sapiens (human)
B cell activation	Histone deacetylase 9	Homo sapiens (human)
cholesterol homeostasis	Histone deacetylase 9	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Histone deacetylase 9	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 9	Homo sapiens (human)
regulation of skeletal muscle fiber development	Histone deacetylase 9	Homo sapiens (human)
regulation of striated muscle cell differentiation	Histone deacetylase 9	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	Histone deacetylase 9	Homo sapiens (human)
regulation of cell growth	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein targeting to membrane	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
apoptotic process	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
DNA damage response	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
mitotic G2 DNA damage checkpoint signaling	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
axonogenesis	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
regulation of cell shape	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
cell migration	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
actin cytoskeleton organization	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
positive regulation of protein autophosphorylation	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
activation of protein kinase activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
positive regulation of stress-activated MAPK cascade	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
regulation of actin cytoskeleton organization	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
positive regulation of MAPK cascade	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
positive regulation of JNK cascade	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein autophosphorylation	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
focal adhesion assembly	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
stress-activated MAPK cascade	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
basal dendrite morphogenesis	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
basal dendrite arborization	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein autophosphorylation	ALK tyrosine kinase receptor	Homo sapiens (human)
signal transduction	ALK tyrosine kinase receptor	Homo sapiens (human)
cell surface receptor protein tyrosine kinase signaling pathway	ALK tyrosine kinase receptor	Homo sapiens (human)
phosphorylation	ALK tyrosine kinase receptor	Homo sapiens (human)
hippocampus development	ALK tyrosine kinase receptor	Homo sapiens (human)
adult behavior	ALK tyrosine kinase receptor	Homo sapiens (human)
swimming behavior	ALK tyrosine kinase receptor	Homo sapiens (human)
peptidyl-tyrosine autophosphorylation	ALK tyrosine kinase receptor	Homo sapiens (human)
regulation of apoptotic process	ALK tyrosine kinase receptor	Homo sapiens (human)
protein autophosphorylation	ALK tyrosine kinase receptor	Homo sapiens (human)
neuron development	ALK tyrosine kinase receptor	Homo sapiens (human)
negative regulation of lipid catabolic process	ALK tyrosine kinase receptor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	ALK tyrosine kinase receptor	Homo sapiens (human)
regulation of dopamine receptor signaling pathway	ALK tyrosine kinase receptor	Homo sapiens (human)
response to environmental enrichment	ALK tyrosine kinase receptor	Homo sapiens (human)
energy homeostasis	ALK tyrosine kinase receptor	Homo sapiens (human)
positive regulation of dendrite development	ALK tyrosine kinase receptor	Homo sapiens (human)
regulation of neuron differentiation	ALK tyrosine kinase receptor	Homo sapiens (human)
regulation of cell population proliferation	ALK tyrosine kinase receptor	Homo sapiens (human)
multicellular organism development	ALK tyrosine kinase receptor	Homo sapiens (human)
positive regulation of kinase activity	ALK tyrosine kinase receptor	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase ICK	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase ICK	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase ICK	Homo sapiens (human)
intraciliary anterograde transport	Serine/threonine-protein kinase ICK	Homo sapiens (human)
intraciliary retrograde transport	Serine/threonine-protein kinase ICK	Homo sapiens (human)
intraciliary transport	Serine/threonine-protein kinase ICK	Homo sapiens (human)
cilium assembly	Serine/threonine-protein kinase ICK	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 5	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Histone deacetylase 5	Homo sapiens (human)
inflammatory response	Histone deacetylase 5	Homo sapiens (human)
response to xenobiotic stimulus	Histone deacetylase 5	Homo sapiens (human)
regulation of myotube differentiation	Histone deacetylase 5	Homo sapiens (human)
negative regulation of myotube differentiation	Histone deacetylase 5	Homo sapiens (human)
response to activity	Histone deacetylase 5	Homo sapiens (human)
neuron differentiation	Histone deacetylase 5	Homo sapiens (human)
B cell differentiation	Histone deacetylase 5	Homo sapiens (human)
cellular response to insulin stimulus	Histone deacetylase 5	Homo sapiens (human)
B cell activation	Histone deacetylase 5	Homo sapiens (human)
response to cocaine	Histone deacetylase 5	Homo sapiens (human)
regulation of protein binding	Histone deacetylase 5	Homo sapiens (human)
negative regulation of gene expression, epigenetic	Histone deacetylase 5	Homo sapiens (human)
negative regulation of DNA-templated transcription	Histone deacetylase 5	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Histone deacetylase 5	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Histone deacetylase 5	Homo sapiens (human)
cellular response to lipopolysaccharide	Histone deacetylase 5	Homo sapiens (human)
negative regulation of cell migration involved in sprouting angiogenesis	Histone deacetylase 5	Homo sapiens (human)
mitochondrial genome maintenance	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of endothelial cell proliferation	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
protein phosphorylation	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
signal transduction	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of TOR signaling	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of angiogenesis	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell size	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
brain morphogenesis	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
homeostasis of number of cells within a tissue	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesis	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of vascular endothelial cell proliferation	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
positive regulation of artery morphogenesis	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
negative regulation of cellular senescence	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
intracellular signal transduction	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
peptidyl-serine phosphorylation	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
positive regulation of TORC1 signaling	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
positive regulation of TORC2 signaling	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
microtubule cytoskeleton organization	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
intracellular signal transduction	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
cellular response to mechanical stimulus	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
regulation of alternative mRNA splicing, via spliceosome	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nuclear-transcribed mRNA catabolic process	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
mRNA processing	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
circadian rhythm	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
RNA splicing	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
positive regulation of circadian rhythm	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
positive regulation of DNA-templated transcription	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
positive regulation of mRNA splicing, via spliceosome	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
mRNA stabilization	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
protein phosphorylation	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
regulation of T cell mediated cytotoxicity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of adaptive immune response	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of phosphatase activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
activation of protein kinase activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of type II interferon production	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
T cell differentiation in thymus	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein modification process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of apoptotic process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
T cell homeostasis	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of DNA-templated transcription	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of activated T cell proliferation	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein autophosphorylation	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
lymph node development	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
spleen development	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
thymus development	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
defense response to virus	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of necroptotic process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of activation-induced cell death of T cells	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
necroptotic process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
cellular response to hydrogen peroxide	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
reactive oxygen species metabolic process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
apoptotic signaling pathway	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
programmed necrotic cell death	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
necroptotic signaling pathway	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
execution phase of necroptosis	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
amyloid fibril formation	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
signal transduction	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein phosphorylation	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cytoskeleton organization	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
establishment or maintenance of cell polarity	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
signal transduction	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cell migration	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
actin cytoskeleton organization	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
actomyosin structure organization	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
peptidyl-threonine phosphorylation	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
positive regulation of cytokine production	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of cytokine-mediated signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
MyD88-dependent toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein phosphorylation	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
response to virus	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
positive regulation of macrophage tolerance induction	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of macrophage cytokine production	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
cytokine-mediated signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
response to peptidoglycan	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
response to lipopolysaccharide	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of interleukin-12 production	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of interleukin-6 production	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of tumor necrosis factor production	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of toll-like receptor signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of protein catabolic process	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of protein-containing complex disassembly	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
regulation of protein-containing complex disassembly	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
response to exogenous dsRNA	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of MAP kinase activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
negative regulation of innate immune response	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
response to interleukin-1	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
Toll signaling pathway	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
cellular response to lipopolysaccharide	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
intracellular signal transduction	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
Wnt signaling pathway	Casein kinase I isoform gamma-3	Homo sapiens (human)
protein modification process	Casein kinase I isoform gamma-3	Homo sapiens (human)
peptidyl-serine phosphorylation	Casein kinase I isoform gamma-3	Homo sapiens (human)
signal transduction	Casein kinase I isoform gamma-3	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Casein kinase I isoform gamma-3	Homo sapiens (human)
endocytosis	Casein kinase I isoform gamma-3	Homo sapiens (human)
MAPK cascade	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
placenta development	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
response to UV-C	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
regulation of gene expression	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
male germ-line sex determination	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
positive regulation of telomere maintenance via telomerase	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
intracellular signal transduction	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
positive regulation of JUN kinase activity	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
positive regulation of telomerase activity	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
chorionic trophoblast cell differentiation	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
positive regulation of p38MAPK cascade	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
positive regulation of telomere capping	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (540)

Process	via Protein(s)	Taxonomy
protein serine/threonine kinase activity	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
transmembrane receptor protein serine/threonine kinase activity	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
transmembrane signaling receptor activity	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
protein binding	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
ATP binding	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
BMP binding	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
SMAD binding	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
metal ion binding	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
BMP receptor activity	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
transforming growth factor beta receptor activity, type I	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
amyloid-beta binding	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
steroid binding	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
protein binding	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
heme binding	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
protein homodimerization activity	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
metal ion binding	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
DNA binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
DNA helicase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
RNA binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
RNA helicase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
mRNA binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
GTPase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
protein binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
ATP binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
transcription factor binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
poly(A) binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
eukaryotic initiation factor 4E binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
ATP hydrolysis activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
ribonucleoside triphosphate phosphatase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
translation initiation factor binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
RNA strand annealing activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
signaling adaptor activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
RNA stem-loop binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
gamma-tubulin binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
ribosomal small subunit binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
CTPase activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
protein serine/threonine kinase activator activity	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cadherin binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
mRNA 5'-UTR binding	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
magnesium ion binding	Pyridoxal kinase	Homo sapiens (human)
ATP binding	Pyridoxal kinase	Homo sapiens (human)
zinc ion binding	Pyridoxal kinase	Homo sapiens (human)
pyridoxal kinase activity	Pyridoxal kinase	Homo sapiens (human)
pyridoxal phosphate binding	Pyridoxal kinase	Homo sapiens (human)
potassium ion binding	Pyridoxal kinase	Homo sapiens (human)
sodium ion binding	Pyridoxal kinase	Homo sapiens (human)
lithium ion binding	Pyridoxal kinase	Homo sapiens (human)
protein homodimerization activity	Pyridoxal kinase	Homo sapiens (human)
transcription coactivator binding	Citron Rho-interacting kinase	Homo sapiens (human)
protein serine/threonine kinase activity	Citron Rho-interacting kinase	Homo sapiens (human)
protein binding	Citron Rho-interacting kinase	Homo sapiens (human)
ATP binding	Citron Rho-interacting kinase	Homo sapiens (human)
SH3 domain binding	Citron Rho-interacting kinase	Homo sapiens (human)
protein kinase binding	Citron Rho-interacting kinase	Homo sapiens (human)
PDZ domain binding	Citron Rho-interacting kinase	Homo sapiens (human)
protein serine/threonine kinase inhibitor activity	Citron Rho-interacting kinase	Homo sapiens (human)
metal ion binding	Citron Rho-interacting kinase	Homo sapiens (human)
scaffold protein binding	Citron Rho-interacting kinase	Homo sapiens (human)
protein serine kinase activity	Citron Rho-interacting kinase	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein domain specific binding	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
histone H3T11 kinase activity	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein kinase activity	Aurora kinase A	Homo sapiens (human)
protein serine/threonine kinase activity	Aurora kinase A	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Aurora kinase A	Homo sapiens (human)
protein binding	Aurora kinase A	Homo sapiens (human)
ATP binding	Aurora kinase A	Homo sapiens (human)
protein kinase binding	Aurora kinase A	Homo sapiens (human)
ubiquitin protein ligase binding	Aurora kinase A	Homo sapiens (human)
histone H3S10 kinase activity	Aurora kinase A	Homo sapiens (human)
protein heterodimerization activity	Aurora kinase A	Homo sapiens (human)
protein serine kinase activity	Aurora kinase A	Homo sapiens (human)
molecular function activator activity	Aurora kinase A	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-G-associated kinase	Homo sapiens (human)
protein binding	Cyclin-G-associated kinase	Homo sapiens (human)
ATP binding	Cyclin-G-associated kinase	Homo sapiens (human)
cyclin binding	Cyclin-G-associated kinase	Homo sapiens (human)
protein-folding chaperone binding	Cyclin-G-associated kinase	Homo sapiens (human)
protein serine kinase activity	Cyclin-G-associated kinase	Homo sapiens (human)
clathrin binding	Cyclin-G-associated kinase	Homo sapiens (human)
ephrin receptor activity	Ephrin type-B receptor 6	Homo sapiens (human)
protein binding	Ephrin type-B receptor 6	Homo sapiens (human)
ATP binding	Ephrin type-B receptor 6	Homo sapiens (human)
signaling receptor activity	Ephrin type-B receptor 6	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-B receptor 6	Homo sapiens (human)
FAD binding	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
flavin adenine dinucleotide binding	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
pristanoyl-CoA oxidase activity	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
fatty acid binding	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
transcription corepressor binding	Histone deacetylase 3	Homo sapiens (human)
chromatin binding	Histone deacetylase 3	Homo sapiens (human)
transcription corepressor activity	Histone deacetylase 3	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 3	Homo sapiens (human)
protein binding	Histone deacetylase 3	Homo sapiens (human)
enzyme binding	Histone deacetylase 3	Homo sapiens (human)
cyclin binding	Histone deacetylase 3	Homo sapiens (human)
chromatin DNA binding	Histone deacetylase 3	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 3	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 3	Homo sapiens (human)
NF-kappaB binding	Histone deacetylase 3	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 3	Homo sapiens (human)
protein decrotonylase activity	Histone deacetylase 3	Homo sapiens (human)
histone decrotonylase activity	Histone deacetylase 3	Homo sapiens (human)
protein de-2-hydroxyisobutyrylase activity	Histone deacetylase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
signaling receptor binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
ATP binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
LIM domain binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
signaling adaptor activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
identical protein binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein homodimerization activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
CARD domain binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
caspase binding	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein serine kinase activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
JUN kinase kinase kinase activity	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein kinase activity	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
protein serine/threonine kinase activity	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
protein binding	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
ATP binding	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
protein serine kinase activity	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
histone H2A kinase activity	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
magnesium ion binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
GTPase activity	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
protein binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
GTP binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
phosphatidic acid binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
GTPase-dependent fusogenic activity	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
membrane bending activity	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
cardiolipin binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
microtubule binding	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
telomeric DNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
p53 binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromatin binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription coactivator activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
oxidoreductase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
enzyme binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nuclear receptor coactivator activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone H3K4 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
histone H3K9 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
identical protein binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
MRF binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
flavin adenine dinucleotide binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nuclear androgen receptor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
telomeric repeat-containing RNA binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA-binding transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
FAD-dependent H3K4me/H3K4me3 demethylase activity	Lysine-specific histone demethylase 1A	Homo sapiens (human)
promoter-specific chromatin binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription factor binding	Lysine-specific histone demethylase 1A	Homo sapiens (human)
ATP binding	Putative nucleoside diphosphate kinase	Homo sapiens (human)
metal ion binding	Putative nucleoside diphosphate kinase	Homo sapiens (human)
nucleoside diphosphate kinase activity	Putative nucleoside diphosphate kinase	Homo sapiens (human)
tRNA binding	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
RNA binding	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
translation initiation factor activity	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
GTPase activity	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
protein binding	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
GTP binding	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
metal ion binding	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
protease binding	Rho-associated protein kinase 2	Homo sapiens (human)
RNA binding	Rho-associated protein kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Rho-associated protein kinase 2	Homo sapiens (human)
structural molecule activity	Rho-associated protein kinase 2	Homo sapiens (human)
protein binding	Rho-associated protein kinase 2	Homo sapiens (human)
ATP binding	Rho-associated protein kinase 2	Homo sapiens (human)
small GTPase binding	Rho-associated protein kinase 2	Homo sapiens (human)
metal ion binding	Rho-associated protein kinase 2	Homo sapiens (human)
tau protein binding	Rho-associated protein kinase 2	Homo sapiens (human)
tau-protein kinase activity	Rho-associated protein kinase 2	Homo sapiens (human)
endopeptidase activator activity	Rho-associated protein kinase 2	Homo sapiens (human)
Rho-dependent protein serine/threonine kinase activity	Rho-associated protein kinase 2	Homo sapiens (human)
protein serine kinase activity	Rho-associated protein kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein-containing complex binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
GTPase binding	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
RNA endonuclease activity	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
platelet-derived growth factor receptor binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
enzyme binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
Hsp70 protein binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein homodimerization activity	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
ADP binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
Hsp90 protein binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
unfolded protein binding	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
magnesium ion binding	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
protein serine/threonine kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
protein tyrosine kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
histone H3S10 kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
histone H3S28 kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
histone H2AS1 kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
RNA binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
RNA helicase activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
helicase activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
protein binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
ATP binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
ATP hydrolysis activity	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
identical protein binding	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
magnesium ion binding	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
protein serine/threonine kinase activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
ribosomal protein S6 kinase activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
histone H3S10 kinase activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
histone H3S28 kinase activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Serine/threonine-protein kinase 16	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Serine/threonine-protein kinase 16	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 16	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 16	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 16	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 16	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein binding	Cyclin-dependent kinase-like 5	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase-like 5	Homo sapiens (human)
kinase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
small GTPase binding	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase-like 5	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 10	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 10	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 10	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase 10	Homo sapiens (human)
protein homodimerization activity	Serine/threonine-protein kinase 10	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 10	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase D3	Homo sapiens (human)
single-stranded DNA binding	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
protein binding	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
ATP binding	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
ATP hydrolysis activity	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
chromatin binding	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
magnesium ion binding	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)
creatine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
microtubule binding	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
MAP kinase kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein kinase binding	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
nuclear estrogen receptor binding	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cadherin binding involved in cell-cell adhesion	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
supercoiled DNA binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
magnesium ion binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
four-way junction DNA binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
bubble DNA binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
DNA binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
transcription coactivator activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
actin monomer binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nicotinate-nucleotide adenylyltransferase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein kinase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein kinase C binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
kinase activity	Tyrosine-protein kinase ABL1	Homo sapiens (human)
SH3 domain binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
syntaxin binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
manganese ion binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuropilin binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
SH2 domain binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
actin filament binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
mitogen-activated protein kinase binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
proline-rich region binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
delta-catenin binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Tyrosine-protein kinase ABL1	Homo sapiens (human)
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
virus receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
chromatin binding	Epidermal growth factor receptor	Homo sapiens (human)
double-stranded DNA binding	Epidermal growth factor receptor	Homo sapiens (human)
MAP kinase kinase kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane signaling receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor receptor activity	Epidermal growth factor receptor	Homo sapiens (human)
integrin binding	Epidermal growth factor receptor	Homo sapiens (human)
protein binding	Epidermal growth factor receptor	Homo sapiens (human)
calmodulin binding	Epidermal growth factor receptor	Homo sapiens (human)
ATP binding	Epidermal growth factor receptor	Homo sapiens (human)
enzyme binding	Epidermal growth factor receptor	Homo sapiens (human)
kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein kinase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Epidermal growth factor receptor	Homo sapiens (human)
protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activator activity	Epidermal growth factor receptor	Homo sapiens (human)
ubiquitin protein ligase binding	Epidermal growth factor receptor	Homo sapiens (human)
identical protein binding	Epidermal growth factor receptor	Homo sapiens (human)
cadherin binding	Epidermal growth factor receptor	Homo sapiens (human)
actin filament binding	Epidermal growth factor receptor	Homo sapiens (human)
ATPase binding	Epidermal growth factor receptor	Homo sapiens (human)
epidermal growth factor binding	Epidermal growth factor receptor	Homo sapiens (human)
cytokine activity	Interferon beta	Homo sapiens (human)
cytokine receptor binding	Interferon beta	Homo sapiens (human)
type I interferon receptor binding	Interferon beta	Homo sapiens (human)
protein binding	Interferon beta	Homo sapiens (human)
chloramphenicol O-acetyltransferase activity	Interferon beta	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
signaling receptor binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
peptide antigen binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
TAP binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
protein-folding chaperone binding	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
growth factor binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
RNA polymerase I core binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
protein tyrosine kinase activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
transmembrane signaling receptor activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
signaling receptor binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
protein binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ATP binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
coreceptor activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
receptor tyrosine kinase binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
identical protein binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ErbB-3 class receptor binding	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
protein heterodimerization activity	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
protein tyrosine kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	High affinity nerve growth factor receptor	Homo sapiens (human)
GPI-linked ephrin receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin p75 receptor binding	High affinity nerve growth factor receptor	Homo sapiens (human)
protein binding	High affinity nerve growth factor receptor	Homo sapiens (human)
ATP binding	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
kinase binding	High affinity nerve growth factor receptor	Homo sapiens (human)
identical protein binding	High affinity nerve growth factor receptor	Homo sapiens (human)
protein homodimerization activity	High affinity nerve growth factor receptor	Homo sapiens (human)
nerve growth factor binding	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin binding	High affinity nerve growth factor receptor	Homo sapiens (human)
neurotrophin receptor activity	High affinity nerve growth factor receptor	Homo sapiens (human)
protein binding	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
GTP binding	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
metal ion binding	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
G-protein beta/gamma-subunit complex binding	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
G protein-coupled receptor binding	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
GTPase activity	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
adenine nucleotide transmembrane transporter activity	ADP/ATP translocase 2	Homo sapiens (human)
RNA binding	ADP/ATP translocase 2	Homo sapiens (human)
ATP:ADP antiporter activity	ADP/ATP translocase 2	Homo sapiens (human)
protein binding	ADP/ATP translocase 2	Homo sapiens (human)
proton transmembrane transporter activity	ADP/ATP translocase 2	Homo sapiens (human)
adenine transmembrane transporter activity	ADP/ATP translocase 2	Homo sapiens (human)
oxidative phosphorylation uncoupler activity	ADP/ATP translocase 2	Homo sapiens (human)
ubiquitin protein ligase binding	ADP/ATP translocase 2	Homo sapiens (human)
chromatin binding	Protein kinase C beta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C beta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C beta type	Homo sapiens (human)
protein kinase C binding	Protein kinase C beta type	Homo sapiens (human)
calcium channel regulator activity	Protein kinase C beta type	Homo sapiens (human)
protein binding	Protein kinase C beta type	Homo sapiens (human)
ATP binding	Protein kinase C beta type	Homo sapiens (human)
zinc ion binding	Protein kinase C beta type	Homo sapiens (human)
nuclear receptor coactivator activity	Protein kinase C beta type	Homo sapiens (human)
histone H3T6 kinase activity	Protein kinase C beta type	Homo sapiens (human)
histone binding	Protein kinase C beta type	Homo sapiens (human)
nuclear androgen receptor binding	Protein kinase C beta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C beta type	Homo sapiens (human)
amyloid-beta binding	Insulin receptor	Homo sapiens (human)
protein tyrosine kinase activity	Insulin receptor	Homo sapiens (human)
insulin receptor activity	Insulin receptor	Homo sapiens (human)
insulin-like growth factor receptor binding	Insulin receptor	Homo sapiens (human)
protein binding	Insulin receptor	Homo sapiens (human)
ATP binding	Insulin receptor	Homo sapiens (human)
GTP binding	Insulin receptor	Homo sapiens (human)
protein domain specific binding	Insulin receptor	Homo sapiens (human)
insulin-like growth factor I binding	Insulin receptor	Homo sapiens (human)
insulin-like growth factor II binding	Insulin receptor	Homo sapiens (human)
cargo receptor activity	Insulin receptor	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Insulin receptor	Homo sapiens (human)
insulin binding	Insulin receptor	Homo sapiens (human)
insulin receptor substrate binding	Insulin receptor	Homo sapiens (human)
protein-containing complex binding	Insulin receptor	Homo sapiens (human)
PTB domain binding	Insulin receptor	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein serine/threonine phosphatase activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phospholipase activator activity	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein kinase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein phosphatase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
SH2 domain binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
T cell receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
CD4 receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
CD8 receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
ATPase binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Lck	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
phospholipase activator activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
enzyme binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
type 5 metabotropic glutamate receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
alpha-tubulin binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
transmembrane transporter binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
tau protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
tau-protein kinase activity	Tyrosine-protein kinase Fyn	Homo sapiens (human)
growth factor receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
scaffold protein binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
disordered domain specific binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Fyn	Homo sapiens (human)
virus receptor activity	Cyclin-dependent kinase 1	Homo sapiens (human)
chromatin binding	Cyclin-dependent kinase 1	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 1	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 1	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 1	Homo sapiens (human)
Hsp70 protein binding	Cyclin-dependent kinase 1	Homo sapiens (human)
histone kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin-dependent protein kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 1	Homo sapiens (human)
purine nucleobase binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
protein binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
ATP binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
glucose binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
glycogen phosphorylase activity	Glycogen phosphorylase, liver form	Homo sapiens (human)
AMP binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
vitamin binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
bile acid binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
identical protein binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
linear malto-oligosaccharide phosphorylase activity	Glycogen phosphorylase, liver form	Homo sapiens (human)
SHG alpha-glucan phosphorylase activity	Glycogen phosphorylase, liver form	Homo sapiens (human)
pyridoxal phosphate binding	Glycogen phosphorylase, liver form	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
microtubule binding	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
immunoglobulin receptor binding	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
phosphatidylinositol binding	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
adenine phosphoribosyltransferase activity	Adenine phosphoribosyltransferase	Homo sapiens (human)
protein binding	Adenine phosphoribosyltransferase	Homo sapiens (human)
AMP binding	Adenine phosphoribosyltransferase	Homo sapiens (human)
adenine binding	Adenine phosphoribosyltransferase	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Yes	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Yes	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
enzyme binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
transmembrane transporter binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Yes	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Lyn	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Lyn	Homo sapiens (human)
platelet-derived growth factor receptor binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
integrin binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
kinase activity	Tyrosine-protein kinase Lyn	Homo sapiens (human)
SH3 domain binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
ubiquitin protein ligase binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
gamma-tubulin binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
glycosphingolipid binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
transmembrane transporter binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
ephrin receptor binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
phosphoprotein binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
scaffold protein binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
phosphorylation-dependent protein binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Tyrosine-protein kinase Lyn	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase Lyn	Homo sapiens (human)
protein tyrosine kinase activity	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
calcium ion binding	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
protein binding	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
ATP binding	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
signaling receptor activity	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
G-protein alpha-subunit binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein tyrosine kinase activity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin-like growth factor receptor activity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin receptor binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin-like growth factor binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
ATP binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin-like growth factor I binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
identical protein binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
phosphatidylinositol 3-kinase binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin receptor substrate binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein-containing complex binding	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein transporter activity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin receptor activity	Insulin-like growth factor 1 receptor	Homo sapiens (human)
RNA binding	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
GTP binding	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
ATP hydrolysis activity	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
signal recognition particle binding	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
GTPase activity	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
protein binding	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
ubiquinol-cytochrome-c reductase activity	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
heme binding	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
metal ion binding	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
protein tyrosine kinase activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
ATP binding	Hepatocyte growth factor receptor	Homo sapiens (human)
semaphorin receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
protein phosphatase binding	Hepatocyte growth factor receptor	Homo sapiens (human)
identical protein binding	Hepatocyte growth factor receptor	Homo sapiens (human)
molecular function activator activity	Hepatocyte growth factor receptor	Homo sapiens (human)
hepatocyte growth factor receptor activity	Hepatocyte growth factor receptor	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase HCK	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase HCK	Homo sapiens (human)
protein binding	Tyrosine-protein kinase HCK	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase HCK	Homo sapiens (human)
lipid binding	Tyrosine-protein kinase HCK	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase HCK	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase HCK	Homo sapiens (human)
protein kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein tyrosine kinase activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet activating factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor beta-receptor activity	Platelet-derived growth factor receptor beta	Homo sapiens (human)
signaling receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor receptor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
ATP binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
enzyme binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
protein kinase binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
vascular endothelial growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
platelet-derived growth factor binding	Platelet-derived growth factor receptor beta	Homo sapiens (human)
3'-5'-RNA exonuclease activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoesters	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
protein guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
protein kinase activity	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
MAP kinase kinase kinase activity	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
protein binding	Glycogen phosphorylase, brain form	Homo sapiens (human)
glycogen phosphorylase activity	Glycogen phosphorylase, brain form	Homo sapiens (human)
linear malto-oligosaccharide phosphorylase activity	Glycogen phosphorylase, brain form	Homo sapiens (human)
SHG alpha-glucan phosphorylase activity	Glycogen phosphorylase, brain form	Homo sapiens (human)
pyridoxal phosphate binding	Glycogen phosphorylase, brain form	Homo sapiens (human)
protein serine/threonine kinase activity	Breakpoint cluster region protein	Homo sapiens (human)
protein tyrosine kinase activity	Breakpoint cluster region protein	Homo sapiens (human)
guanyl-nucleotide exchange factor activity	Breakpoint cluster region protein	Homo sapiens (human)
GTPase activator activity	Breakpoint cluster region protein	Homo sapiens (human)
protein binding	Breakpoint cluster region protein	Homo sapiens (human)
ATP binding	Breakpoint cluster region protein	Homo sapiens (human)
protein serine kinase activity	Breakpoint cluster region protein	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
transcription factor binding	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
manganese ion binding	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
ribosomal small subunit binding	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
protein tyrosine kinase activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor receptor activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
ATP binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
heparin binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
fibroblast growth factor binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
SH2 domain binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
identical protein binding	Fibroblast growth factor receptor 1	Homo sapiens (human)
protein homodimerization activity	Fibroblast growth factor receptor 1	Homo sapiens (human)
receptor-receptor interaction	Fibroblast growth factor receptor 1	Homo sapiens (human)
magnesium ion binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromatin binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
RNA binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein kinase C binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
ATP binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
ATP-dependent activity, acting on DNA	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA binding, bending	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein homodimerization activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
ubiquitin binding	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein heterodimerization activity	DNA topoisomerase 2-alpha	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 4	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 4	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase regulator activity	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 4	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 4	Homo sapiens (human)
ATP:ADP antiporter activity	ADP/ATP translocase 3	Homo sapiens (human)
protein binding	ADP/ATP translocase 3	Homo sapiens (human)
nucleotide binding	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
DNA binding	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
RNA binding	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
IMP dehydrogenase activity	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
protein binding	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
metal ion binding	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
protein kinase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein tyrosine kinase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein kinase C binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
signaling receptor binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
insulin receptor binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
integrin binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
protein binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ATP binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
phospholipase activator activity	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
enzyme binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
heme binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
nuclear estrogen receptor binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
SH2 domain binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
phospholipase binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
transmembrane transporter binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cadherin binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ephrin receptor binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ATPase binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
phosphoprotein binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
BMP receptor binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
connexin binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
scaffold protein binding	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cAMP-dependent protein kinase inhibitor activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase regulator activity	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein domain specific binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
ubiquitin protein ligase binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein kinase A catalytic subunit binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP binding	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
MAP kinase kinase activity	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
calcium ion binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
mitogen-activated protein kinase kinase binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein-containing complex binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
scaffold protein binding	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
MAP kinase kinase kinase activity	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
protein serine/threonine kinase activity	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
phosphorylase kinase activity	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
protein binding	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
calmodulin binding	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
ATP binding	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
enzyme binding	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
tau-protein kinase activity	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
dihydronicotinamide riboside quinone reductase activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
protein binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
zinc ion binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
electron transfer activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
oxidoreductase activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
oxidoreductase activity, acting on other nitrogenous compounds as donors	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
chloride ion binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
protein homodimerization activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
FAD binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
melatonin binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
resveratrol binding	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
NAD(P)H dehydrogenase (quinone) activity	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Fer	Homo sapiens (human)
epidermal growth factor receptor binding	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Fer	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein phosphatase 1 binding	Tyrosine-protein kinase Fer	Homo sapiens (human)
lipid binding	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase Fer	Homo sapiens (human)
protein kinase activity	Protein kinase C alpha type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
calcium,diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
integrin binding	Protein kinase C alpha type	Homo sapiens (human)
protein binding	Protein kinase C alpha type	Homo sapiens (human)
ATP binding	Protein kinase C alpha type	Homo sapiens (human)
zinc ion binding	Protein kinase C alpha type	Homo sapiens (human)
enzyme binding	Protein kinase C alpha type	Homo sapiens (human)
histone H3T6 kinase activity	Protein kinase C alpha type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C alpha type	Homo sapiens (human)
diacylglycerol binding	Protein kinase C alpha type	Homo sapiens (human)
magnesium ion binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein serine/threonine kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
AMP-activated protein kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cAMP-dependent protein kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
ATP binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein kinase binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein domain specific binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
manganese ion binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
ubiquitin protein ligase binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein kinase A regulatory subunit binding	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
channel activator activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein serine kinase activity	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
protein binding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
ATP binding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
ATP hydrolysis activity	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
protein-macromolecule adaptor activity	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
5'-3' DNA helicase activity	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
metal ion binding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
4 iron, 4 sulfur cluster binding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
DNA helicase activity	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
damaged DNA binding	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase II subunit alpha'	Homo sapiens (human)
protein binding	Casein kinase II subunit alpha'	Homo sapiens (human)
ATP binding	Casein kinase II subunit alpha'	Homo sapiens (human)
protein serine kinase activity	Casein kinase II subunit alpha'	Homo sapiens (human)
GTPase activity	Ras-related protein Rab-6A	Homo sapiens (human)
protein binding	Ras-related protein Rab-6A	Homo sapiens (human)
GTP binding	Ras-related protein Rab-6A	Homo sapiens (human)
protein domain specific binding	Ras-related protein Rab-6A	Homo sapiens (human)
myosin V binding	Ras-related protein Rab-6A	Homo sapiens (human)
fibronectin binding	Ephrin type-A receptor 1	Homo sapiens (human)
protein kinase activity	Ephrin type-A receptor 1	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-A receptor 1	Homo sapiens (human)
ATP binding	Ephrin type-A receptor 1	Homo sapiens (human)
protein kinase binding	Ephrin type-A receptor 1	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Ephrin type-A receptor 1	Homo sapiens (human)
protein tyrosine kinase activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
transmembrane signaling receptor activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
protein binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
ATP binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
growth factor binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
protein tyrosine kinase activator activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
ubiquitin protein ligase binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
neuregulin binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
identical protein binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
ErbB-3 class receptor binding	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
protein heterodimerization activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
neuregulin receptor activity	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
phosphoribosylaminoimidazole carboxylase activity	Multifunctional protein ADE2	Homo sapiens (human)
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	Multifunctional protein ADE2	Homo sapiens (human)
protein binding	Multifunctional protein ADE2	Homo sapiens (human)
ATP binding	Multifunctional protein ADE2	Homo sapiens (human)
identical protein binding	Multifunctional protein ADE2	Homo sapiens (human)
5-amino-4-imidazole carboxylate lyase activity	Multifunctional protein ADE2	Homo sapiens (human)
cadherin binding	Multifunctional protein ADE2	Homo sapiens (human)
DNA binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
transcription coactivator activity	Nucleoside diphosphate kinase B	Homo sapiens (human)
nucleoside diphosphate kinase activity	Nucleoside diphosphate kinase B	Homo sapiens (human)
protein histidine kinase activity	Nucleoside diphosphate kinase B	Homo sapiens (human)
protein binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
ATP binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
GDP binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
metal ion binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
G-quadruplex DNA binding	Nucleoside diphosphate kinase B	Homo sapiens (human)
protein serine/threonine kinase activity	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
AMP-activated protein kinase activity	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
cAMP-dependent protein kinase activity	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
ATP binding	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
protein serine kinase activity	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
protein kinase A regulatory subunit binding	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
magnesium ion binding	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
protein serine/threonine kinase activity	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
AMP-activated protein kinase activity	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
cAMP-dependent protein kinase activity	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
protein binding	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
ATP binding	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
ubiquitin protein ligase binding	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
protein serine kinase activity	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
ferrochelatase activity	Ferrochelatase, mitochondrial	Homo sapiens (human)
protein binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
ferrous iron binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
heme binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
iron-responsive element binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
identical protein binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
protein homodimerization activity	Ferrochelatase, mitochondrial	Homo sapiens (human)
2 iron, 2 sulfur cluster binding	Ferrochelatase, mitochondrial	Homo sapiens (human)
protein kinase activity	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein serine/threonine kinase activity	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
ribosomal protein S6 kinase activity	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
PDZ domain binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
peptide binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
identical protein binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein phosphatase 2A binding	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase JAK1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase JAK1	Homo sapiens (human)
growth hormone receptor binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
protein binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
protein phosphatase binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
ubiquitin protein ligase binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
CCR5 chemokine receptor binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase JAK1	Homo sapiens (human)
histone kinase activity	Cyclin-dependent kinase 2	Homo sapiens (human)
magnesium ion binding	Cyclin-dependent kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 2	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 2	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 2	Homo sapiens (human)
protein domain specific binding	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin-dependent protein kinase activity	Cyclin-dependent kinase 2	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 2	Homo sapiens (human)
protein kinase activity	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
G protein-coupled receptor kinase activity	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
protein binding	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
ATP binding	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
alpha-2A adrenergic receptor binding	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
Edg-2 lysophosphatidic acid receptor binding	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
beta-adrenergic receptor kinase activity	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
G protein-coupled receptor binding	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
RNA binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
RNA helicase activity	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
helicase activity	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
protein binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
ATP binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
ATP hydrolysis activity	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
protein domain specific binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cadherin binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
mRNA binding	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
phosphotyrosine residue binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
phosphatase binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
identical protein binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 3	Homo sapiens (human)
DNA-binding transcription factor binding	Mitogen-activated protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
protein binding	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
ATP binding	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
tau protein binding	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
tau-protein kinase activity	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
protein serine kinase activity	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
deoxyadenosine kinase activity	Deoxycytidine kinase	Homo sapiens (human)
deoxycytidine kinase activity	Deoxycytidine kinase	Homo sapiens (human)
deoxyguanosine kinase activity	Deoxycytidine kinase	Homo sapiens (human)
ATP binding	Deoxycytidine kinase	Homo sapiens (human)
protein homodimerization activity	Deoxycytidine kinase	Homo sapiens (human)
cytidine kinase activity	Deoxycytidine kinase	Homo sapiens (human)
phosphotyrosine residue binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
DNA binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 1	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 1	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Mitogen-activated protein kinase 1	Homo sapiens (human)
phosphatase binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
identical protein binding	Mitogen-activated protein kinase 1	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 1	Homo sapiens (human)
virus receptor activity	Ephrin type-A receptor 2	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Ephrin type-A receptor 2	Homo sapiens (human)
ephrin receptor activity	Ephrin type-A receptor 2	Homo sapiens (human)
protein binding	Ephrin type-A receptor 2	Homo sapiens (human)
ATP binding	Ephrin type-A receptor 2	Homo sapiens (human)
growth factor binding	Ephrin type-A receptor 2	Homo sapiens (human)
cadherin binding	Ephrin type-A receptor 2	Homo sapiens (human)
molecular function activator activity	Ephrin type-A receptor 2	Homo sapiens (human)
amyloid-beta binding	Ephrin type-B receptor 2	Homo sapiens (human)
protein tyrosine kinase activity	Ephrin type-B receptor 2	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-B receptor 2	Homo sapiens (human)
signaling receptor binding	Ephrin type-B receptor 2	Homo sapiens (human)
protein binding	Ephrin type-B receptor 2	Homo sapiens (human)
ATP binding	Ephrin type-B receptor 2	Homo sapiens (human)
axon guidance receptor activity	Ephrin type-B receptor 2	Homo sapiens (human)
identical protein binding	Ephrin type-B receptor 2	Homo sapiens (human)
protein-containing complex binding	Ephrin type-B receptor 2	Homo sapiens (human)
protein tyrosine kinase activity	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
growth hormone receptor binding	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
protein binding	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
ATP binding	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
type 1 angiotensin receptor binding	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
nucleoside diphosphate kinase activity	UMP-CMP kinase	Homo sapiens (human)
uridine kinase activity	UMP-CMP kinase	Homo sapiens (human)
ATP binding	UMP-CMP kinase	Homo sapiens (human)
UMP kinase activity	UMP-CMP kinase	Homo sapiens (human)
CMP kinase activity	UMP-CMP kinase	Homo sapiens (human)
dCMP kinase activity	UMP-CMP kinase	Homo sapiens (human)
nucleoside monophosphate kinase activity	UMP-CMP kinase	Homo sapiens (human)
cytidylate kinase activity	UMP-CMP kinase	Homo sapiens (human)
RNA binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
serine-type endopeptidase inhibitor activity	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
protein binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
ATP binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
phosphatidylethanolamine binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
enzyme binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
protein kinase binding	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
magnesium ion binding	Wee1-like protein kinase	Homo sapiens (human)
protein tyrosine kinase activity	Wee1-like protein kinase	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Wee1-like protein kinase	Homo sapiens (human)
protein binding	Wee1-like protein kinase	Homo sapiens (human)
ATP binding	Wee1-like protein kinase	Homo sapiens (human)
heme oxygenase (decyclizing) activity	Heme oxygenase 2	Homo sapiens (human)
protein binding	Heme oxygenase 2	Homo sapiens (human)
metal ion binding	Heme oxygenase 2	Homo sapiens (human)
heme binding	Heme oxygenase 2	Homo sapiens (human)
methionine adenosyltransferase activity	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
protein binding	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
ATP binding	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
small molecule binding	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
identical protein binding	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
metal ion binding	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
G protein-coupled receptor binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
ATPase activator activity	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
ATP binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
Hsp70 protein binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
Tat protein binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
ubiquitin protein ligase binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
metal ion binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
low-density lipoprotein particle receptor binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
unfolded protein binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein-folding chaperone binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
C3HC4-type RING finger domain binding	DnaJ homolog subfamily A member 1	Homo sapiens (human)
protein kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
calmodulin binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol-3,4,5-trisphosphate binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
enzyme binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein kinase binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nitric-oxide synthase regulator activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase inhibitor activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
identical protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein homodimerization activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
phosphatidylinositol-3,4-bisphosphate binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
14-3-3 protein binding	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
potassium channel activator activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
metal ion binding	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
molecular function activator activity	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
DNA helicase activity	DNA replication licensing factor MCM4	Homo sapiens (human)
single-stranded DNA binding	DNA replication licensing factor MCM4	Homo sapiens (human)
protein binding	DNA replication licensing factor MCM4	Homo sapiens (human)
ATP binding	DNA replication licensing factor MCM4	Homo sapiens (human)
ATP hydrolysis activity	DNA replication licensing factor MCM4	Homo sapiens (human)
single-stranded DNA helicase activity	DNA replication licensing factor MCM4	Homo sapiens (human)
microfilament motor activity	Myosin-10	Homo sapiens (human)
actin filament binding	Myosin-10	Homo sapiens (human)
microfilament motor activity	Myosin-10	Homo sapiens (human)
actin binding	Myosin-10	Homo sapiens (human)
protein binding	Myosin-10	Homo sapiens (human)
calmodulin binding	Myosin-10	Homo sapiens (human)
ATP binding	Myosin-10	Homo sapiens (human)
RNA stem-loop binding	Myosin-10	Homo sapiens (human)
ADP binding	Myosin-10	Homo sapiens (human)
mRNA 5'-UTR binding	Myosin-10	Homo sapiens (human)
actin filament binding	Myosin-10	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
MAP-kinase scaffold activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
PDZ domain binding	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein serine/threonine kinase activator activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
metal ion binding	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
scaffold protein binding	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
protein tyrosine kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
cytokine receptor activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
vascular endothelial growth factor receptor activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
ATP binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
nuclear glucocorticoid receptor binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein-containing complex binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
phosphatidylinositol 3-kinase activator activity	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
growth factor binding	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
protein serine/threonine kinase activity	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
transmembrane receptor protein serine/threonine kinase activity	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
transforming growth factor beta receptor activity, type I	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
protein binding	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
ATP binding	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
BMP binding	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
protein homodimerization activity	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
SMAD binding	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
metal ion binding	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
BMP receptor activity	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
activin receptor activity	Activin receptor type-1B	Homo sapiens (human)
growth factor binding	Activin receptor type-1B	Homo sapiens (human)
activin binding	Activin receptor type-1B	Homo sapiens (human)
protein serine/threonine kinase activity	Activin receptor type-1B	Homo sapiens (human)
transmembrane receptor protein serine/threonine kinase activity	Activin receptor type-1B	Homo sapiens (human)
protein binding	Activin receptor type-1B	Homo sapiens (human)
ATP binding	Activin receptor type-1B	Homo sapiens (human)
activin receptor activity, type I	Activin receptor type-1B	Homo sapiens (human)
activin receptor activity	Activin receptor type-1B	Homo sapiens (human)
ubiquitin protein ligase binding	Activin receptor type-1B	Homo sapiens (human)
inhibin binding	Activin receptor type-1B	Homo sapiens (human)
SMAD binding	Activin receptor type-1B	Homo sapiens (human)
metal ion binding	Activin receptor type-1B	Homo sapiens (human)
I-SMAD binding	Activin receptor type-1B	Homo sapiens (human)
transforming growth factor beta receptor activity	TGF-beta receptor type-1	Homo sapiens (human)
growth factor binding	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta binding	TGF-beta receptor type-1	Homo sapiens (human)
protein kinase activity	TGF-beta receptor type-1	Homo sapiens (human)
protein serine/threonine kinase activity	TGF-beta receptor type-1	Homo sapiens (human)
transmembrane receptor protein serine/threonine kinase activity	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta receptor activity	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta receptor activity, type I	TGF-beta receptor type-1	Homo sapiens (human)
type II transforming growth factor beta receptor binding	TGF-beta receptor type-1	Homo sapiens (human)
protein binding	TGF-beta receptor type-1	Homo sapiens (human)
ATP binding	TGF-beta receptor type-1	Homo sapiens (human)
ubiquitin protein ligase binding	TGF-beta receptor type-1	Homo sapiens (human)
SMAD binding	TGF-beta receptor type-1	Homo sapiens (human)
metal ion binding	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta binding	TGF-beta receptor type-1	Homo sapiens (human)
I-SMAD binding	TGF-beta receptor type-1	Homo sapiens (human)
activin receptor activity, type I	TGF-beta receptor type-1	Homo sapiens (human)
activin binding	TGF-beta receptor type-1	Homo sapiens (human)
protein binding	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
electron transfer activity	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
transcription elongation factor activity	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
ubiquitin-protein transferase activity	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
protein binding	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
enzyme binding	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
molecular adaptor activity	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
DNA-binding transcription factor binding	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
ubiquitin-like ligase-substrate adaptor activity	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase CSK	Homo sapiens (human)
protein binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
protein phosphatase binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
protein kinase A catalytic subunit binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
proline-rich region binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
protein tyrosine kinase binding	Tyrosine-protein kinase CSK	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase CSK	Homo sapiens (human)
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	Glycine--tRNA ligase	Homo sapiens (human)
glycine-tRNA ligase activity	Glycine--tRNA ligase	Homo sapiens (human)
protein binding	Glycine--tRNA ligase	Homo sapiens (human)
ATP binding	Glycine--tRNA ligase	Homo sapiens (human)
transferase activity	Glycine--tRNA ligase	Homo sapiens (human)
identical protein binding	Glycine--tRNA ligase	Homo sapiens (human)
protein dimerization activity	Glycine--tRNA ligase	Homo sapiens (human)
protein kinase activity	Protein kinase C iota type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C iota type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C iota type	Homo sapiens (human)
protein binding	Protein kinase C iota type	Homo sapiens (human)
ATP binding	Protein kinase C iota type	Homo sapiens (human)
phospholipid binding	Protein kinase C iota type	Homo sapiens (human)
metal ion binding	Protein kinase C iota type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C iota type	Homo sapiens (human)
RNA binding	Exosome RNA helicase MTR4	Homo sapiens (human)
RNA helicase activity	Exosome RNA helicase MTR4	Homo sapiens (human)
protein binding	Exosome RNA helicase MTR4	Homo sapiens (human)
ATP binding	Exosome RNA helicase MTR4	Homo sapiens (human)
ATP hydrolysis activity	Exosome RNA helicase MTR4	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase Tec	Homo sapiens (human)
protein binding	Tyrosine-protein kinase Tec	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase Tec	Homo sapiens (human)
phospholipid binding	Tyrosine-protein kinase Tec	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase Tec	Homo sapiens (human)
magnesium ion binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
actin monomer binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein kinase activity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
manganese ion binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
actin filament binding	Tyrosine-protein kinase ABL2	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase FRK	Homo sapiens (human)
protein binding	Tyrosine-protein kinase FRK	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase FRK	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase FRK	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase FRK	Homo sapiens (human)
protein binding	G protein-coupled receptor kinase 6	Homo sapiens (human)
ATP binding	G protein-coupled receptor kinase 6	Homo sapiens (human)
beta-adrenergic receptor kinase activity	G protein-coupled receptor kinase 6	Homo sapiens (human)
G protein-coupled receptor kinase activity	G protein-coupled receptor kinase 6	Homo sapiens (human)
phosphotyrosine residue binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein kinase activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein serine/threonine kinase activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
signaling receptor binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
integrin binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
interleukin-15 receptor binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
kinase activity	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein kinase binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
phosphatase binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
Toll-like receptor binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
SH2 domain binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
scaffold protein binding	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein binding	26S proteasome regulatory subunit 6B	Homo sapiens (human)
ATP binding	26S proteasome regulatory subunit 6B	Homo sapiens (human)
ATP hydrolysis activity	26S proteasome regulatory subunit 6B	Homo sapiens (human)
proteasome-activating activity	26S proteasome regulatory subunit 6B	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
JUN kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
enzyme binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein phosphatase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
histone deacetylase regulator activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
histone deacetylase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein serine/threonine kinase binding	Mitogen-activated protein kinase 8	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 9	Homo sapiens (human)
JUN kinase activity	Mitogen-activated protein kinase 9	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Mitogen-activated protein kinase 9	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 9	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 9	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 9	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
protein kinase binding	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
protein binding	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
ATP binding	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 5-kinase activity	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
1-phosphatidylinositol-5-phosphate 4-kinase activity	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
protein homodimerization activity	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
protein kinase activity	Casein kinase I isoform alpha	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform alpha	Homo sapiens (human)
protein binding	Casein kinase I isoform alpha	Homo sapiens (human)
ATP binding	Casein kinase I isoform alpha	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform alpha	Homo sapiens (human)
protein kinase activity	Casein kinase I isoform delta	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform delta	Homo sapiens (human)
protein binding	Casein kinase I isoform delta	Homo sapiens (human)
ATP binding	Casein kinase I isoform delta	Homo sapiens (human)
cadherin binding	Casein kinase I isoform delta	Homo sapiens (human)
tau-protein kinase activity	Casein kinase I isoform delta	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform delta	Homo sapiens (human)
protein kinase activity	MAP kinase-activated protein kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	MAP kinase-activated protein kinase 2	Homo sapiens (human)
protein binding	MAP kinase-activated protein kinase 2	Homo sapiens (human)
ATP binding	MAP kinase-activated protein kinase 2	Homo sapiens (human)
protein serine kinase activity	MAP kinase-activated protein kinase 2	Homo sapiens (human)
calcium-dependent protein serine/threonine kinase activity	MAP kinase-activated protein kinase 2	Homo sapiens (human)
calmodulin binding	MAP kinase-activated protein kinase 2	Homo sapiens (human)
calmodulin-dependent protein kinase activity	MAP kinase-activated protein kinase 2	Homo sapiens (human)
mitogen-activated protein kinase binding	MAP kinase-activated protein kinase 2	Homo sapiens (human)
RNA binding	Elongation factor Tu, mitochondrial	Homo sapiens (human)
translation elongation factor activity	Elongation factor Tu, mitochondrial	Homo sapiens (human)
GTPase activity	Elongation factor Tu, mitochondrial	Homo sapiens (human)
protein binding	Elongation factor Tu, mitochondrial	Homo sapiens (human)
GTP binding	Elongation factor Tu, mitochondrial	Homo sapiens (human)
tRNA binding	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cysteine-tRNA ligase activity	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
protein binding	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
ATP binding	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
identical protein binding	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
metal ion binding	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
RNA binding	Casein kinase I isoform epsilon	Homo sapiens (human)
protein kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
protein binding	Casein kinase I isoform epsilon	Homo sapiens (human)
ATP binding	Casein kinase I isoform epsilon	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform epsilon	Homo sapiens (human)
acyl-CoA dehydrogenase activity	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
long-chain fatty acyl-CoA dehydrogenase activity	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
protein binding	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
very-long-chain fatty acyl-CoA dehydrogenase activity	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
identical protein binding	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
flavin adenine dinucleotide binding	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
fatty-acyl-CoA binding	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity protein kinase CLK1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein binding	Dual specificity protein kinase CLK1	Homo sapiens (human)
ATP binding	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein serine kinase activity	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity protein kinase CLK1	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein binding	Dual specificity protein kinase CLK2	Homo sapiens (human)
ATP binding	Dual specificity protein kinase CLK2	Homo sapiens (human)
identical protein binding	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein serine kinase activity	Dual specificity protein kinase CLK2	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity protein kinase CLK2	Homo sapiens (human)
RNA binding	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein binding	Dual specificity protein kinase CLK3	Homo sapiens (human)
ATP binding	Dual specificity protein kinase CLK3	Homo sapiens (human)
identical protein binding	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein serine kinase activity	Dual specificity protein kinase CLK3	Homo sapiens (human)
protein serine/threonine kinase activity	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
signaling receptor binding	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
protein binding	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
ATP binding	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
protein kinase A catalytic subunit binding	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
tau protein binding	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
tau-protein kinase activity	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
protein serine kinase activity	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
protease binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
p53 binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein kinase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein serine/threonine kinase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
ATP binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
beta-catenin binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
kinase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein kinase binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
ubiquitin protein ligase binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein kinase A catalytic subunit binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
dynactin binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
tau protein binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
tau-protein kinase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
NF-kappaB binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein serine kinase activity	Glycogen synthase kinase-3 beta	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 7	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase 7	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 7	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 7	Homo sapiens (human)
ATP-dependent activity, acting on DNA	Cyclin-dependent kinase 7	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Cyclin-dependent kinase 7	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 7	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 7	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription coactivator binding	Cyclin-dependent kinase 9	Homo sapiens (human)
DNA binding	Cyclin-dependent kinase 9	Homo sapiens (human)
chromatin binding	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription elongation factor activity	Cyclin-dependent kinase 9	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 9	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 9	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
protein kinase binding	Cyclin-dependent kinase 9	Homo sapiens (human)
7SK snRNA binding	Cyclin-dependent kinase 9	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 9	Homo sapiens (human)
GTPase activity	Ras-related protein Rab-27A	Homo sapiens (human)
G protein activity	Ras-related protein Rab-27A	Homo sapiens (human)
protein binding	Ras-related protein Rab-27A	Homo sapiens (human)
GTP binding	Ras-related protein Rab-27A	Homo sapiens (human)
GDP binding	Ras-related protein Rab-27A	Homo sapiens (human)
protein domain specific binding	Ras-related protein Rab-27A	Homo sapiens (human)
myosin V binding	Ras-related protein Rab-27A	Homo sapiens (human)
protein kinase activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein binding	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
ATP binding	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
kinase activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein kinase binding	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
heat shock protein binding	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
identical protein binding	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein homodimerization activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein heterodimerization activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein serine kinase activity	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
magnesium ion binding	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein kinase activity	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein serine/threonine kinase activity	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein kinase binding	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
ribosomal protein S6 kinase activity	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein phosphatase binding	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein kinase binding	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
serine-type endopeptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
protein binding	Dipeptidyl peptidase 1	Homo sapiens (human)
cysteine-type peptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
dipeptidyl-peptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
peptidase activator activity involved in apoptotic process	Dipeptidyl peptidase 1	Homo sapiens (human)
phosphatase binding	Dipeptidyl peptidase 1	Homo sapiens (human)
chloride ion binding	Dipeptidyl peptidase 1	Homo sapiens (human)
identical protein binding	Dipeptidyl peptidase 1	Homo sapiens (human)
protein-folding chaperone binding	Dipeptidyl peptidase 1	Homo sapiens (human)
cysteine-type endopeptidase activity	Dipeptidyl peptidase 1	Homo sapiens (human)
protein kinase activity	LIM domain kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	LIM domain kinase 1	Homo sapiens (human)
protein binding	LIM domain kinase 1	Homo sapiens (human)
ATP binding	LIM domain kinase 1	Homo sapiens (human)
heat shock protein binding	LIM domain kinase 1	Homo sapiens (human)
metal ion binding	LIM domain kinase 1	Homo sapiens (human)
protein serine kinase activity	LIM domain kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	LIM domain kinase 2	Homo sapiens (human)
protein binding	LIM domain kinase 2	Homo sapiens (human)
ATP binding	LIM domain kinase 2	Homo sapiens (human)
metal ion binding	LIM domain kinase 2	Homo sapiens (human)
protein serine kinase activity	LIM domain kinase 2	Homo sapiens (human)
JUN kinase activity	Mitogen-activated protein kinase 10	Homo sapiens (human)
MAP kinase kinase activity	Mitogen-activated protein kinase 10	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 10	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 10	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 10	Homo sapiens (human)
tRNA binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
RNA binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
tyrosine-tRNA ligase activity	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
interleukin-8 receptor binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
protein binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
ATP binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
small molecule binding	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
protein kinase activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
cAMP-dependent protein kinase activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
protein binding	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
ATP binding	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
cAMP-dependent protein kinase regulator activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
AMP binding	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
protein kinase regulator activity	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
protein kinase binding	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
ADP binding	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
ephrin receptor activity	Ephrin type-B receptor 3	Homo sapiens (human)
protein binding	Ephrin type-B receptor 3	Homo sapiens (human)
ATP binding	Ephrin type-B receptor 3	Homo sapiens (human)
axon guidance receptor activity	Ephrin type-B receptor 3	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-B receptor 3	Homo sapiens (human)
ephrin receptor activity	Ephrin type-A receptor 5	Homo sapiens (human)
GPI-linked ephrin receptor activity	Ephrin type-A receptor 5	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-A receptor 5	Homo sapiens (human)
protein binding	Ephrin type-A receptor 5	Homo sapiens (human)
ATP binding	Ephrin type-A receptor 5	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Ephrin type-B receptor 4	Homo sapiens (human)
ephrin receptor activity	Ephrin type-B receptor 4	Homo sapiens (human)
protein binding	Ephrin type-B receptor 4	Homo sapiens (human)
ATP binding	Ephrin type-B receptor 4	Homo sapiens (human)
amyloid-beta binding	Ephrin type-A receptor 4	Homo sapiens (human)
protein kinase activity	Ephrin type-A receptor 4	Homo sapiens (human)
protein tyrosine kinase activity	Ephrin type-A receptor 4	Homo sapiens (human)
GPI-linked ephrin receptor activity	Ephrin type-A receptor 4	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-A receptor 4	Homo sapiens (human)
protein binding	Ephrin type-A receptor 4	Homo sapiens (human)
ATP binding	Ephrin type-A receptor 4	Homo sapiens (human)
kinase activity	Ephrin type-A receptor 4	Homo sapiens (human)
PH domain binding	Ephrin type-A receptor 4	Homo sapiens (human)
identical protein binding	Ephrin type-A receptor 4	Homo sapiens (human)
ephrin receptor binding	Ephrin type-A receptor 4	Homo sapiens (human)
DH domain binding	Ephrin type-A receptor 4	Homo sapiens (human)
protein tyrosine kinase binding	Ephrin type-A receptor 4	Homo sapiens (human)
adenylate kinase activity	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
protein binding	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
ATP binding	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
RNA binding	Adenosine kinase	Homo sapiens (human)
deoxyadenosine kinase activity	Adenosine kinase	Homo sapiens (human)
ATP binding	Adenosine kinase	Homo sapiens (human)
metal ion binding	Adenosine kinase	Homo sapiens (human)
adenosine kinase activity	Adenosine kinase	Homo sapiens (human)
transcription cis-regulatory region binding	Histone deacetylase 4	Homo sapiens (human)
histone binding	Histone deacetylase 4	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Histone deacetylase 4	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 4	Homo sapiens (human)
protein binding	Histone deacetylase 4	Homo sapiens (human)
zinc ion binding	Histone deacetylase 4	Homo sapiens (human)
SUMO transferase activity	Histone deacetylase 4	Homo sapiens (human)
potassium ion binding	Histone deacetylase 4	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 4	Homo sapiens (human)
identical protein binding	Histone deacetylase 4	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 4	Homo sapiens (human)
molecular adaptor activity	Histone deacetylase 4	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Histone deacetylase 4	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 4	Homo sapiens (human)
G protein activity	Ras-related protein Rab-10	Homo sapiens (human)
protein binding	Ras-related protein Rab-10	Homo sapiens (human)
GTP binding	Ras-related protein Rab-10	Homo sapiens (human)
GDP binding	Ras-related protein Rab-10	Homo sapiens (human)
myosin V binding	Ras-related protein Rab-10	Homo sapiens (human)
cadherin binding involved in cell-cell adhesion	Ras-related protein Rab-10	Homo sapiens (human)
actin filament binding	Actin-related protein 3	Homo sapiens (human)
structural constituent of cytoskeleton	Actin-related protein 3	Homo sapiens (human)
protein binding	Actin-related protein 3	Homo sapiens (human)
ATP binding	Actin-related protein 3	Homo sapiens (human)
actin filament binding	Actin-related protein 2	Homo sapiens (human)
structural constituent of cytoskeleton	Actin-related protein 2	Homo sapiens (human)
protein binding	Actin-related protein 2	Homo sapiens (human)
ATP binding	Actin-related protein 2	Homo sapiens (human)
nuclear export signal receptor activity	GTP-binding nuclear protein Ran	Homo sapiens (human)
pre-miRNA binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
magnesium ion binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
chromatin binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
RNA binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
GTPase activity	GTP-binding nuclear protein Ran	Homo sapiens (human)
G protein activity	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
GTP binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
GDP binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein domain specific binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
cadherin binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
dynein intermediate chain binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein heterodimerization activity	GTP-binding nuclear protein Ran	Homo sapiens (human)
importin-alpha family protein binding	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform gamma-2	Homo sapiens (human)
protein binding	Casein kinase I isoform gamma-2	Homo sapiens (human)
ATP binding	Casein kinase I isoform gamma-2	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform gamma-2	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 3	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 3	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 3	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 3	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 3	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 6	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 6	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 6	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 6	Homo sapiens (human)
FBXO family protein binding	Cyclin-dependent kinase 6	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 6	Homo sapiens (human)
microtubule binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
p53 binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
ErbB-2 class receptor binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
ATP binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
acetylcholine receptor activator activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
ErbB-3 class receptor binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
tau protein binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
tau-protein kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
Hsp90 protein binding	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	Cyclin-dependent kinase 16	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 16	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 16	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 16	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 16	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 17	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 17	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 17	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 17	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 17	Homo sapiens (human)
6-phosphofructokinase activity	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
protein binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
protein-containing complex binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
cadherin binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
metal ion binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
ATP binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
monosaccharide binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
AMP binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
identical protein binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
fructose-6-phosphate binding	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
protein kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
MAP-kinase scaffold activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein kinase activator activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein serine/threonine kinase activator activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
scaffold protein binding	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
DNA binding	DNA topoisomerase 2-beta	Homo sapiens (human)
chromatin binding	DNA topoisomerase 2-beta	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	DNA topoisomerase 2-beta	Homo sapiens (human)
protein binding	DNA topoisomerase 2-beta	Homo sapiens (human)
ATP binding	DNA topoisomerase 2-beta	Homo sapiens (human)
ribonucleoprotein complex binding	DNA topoisomerase 2-beta	Homo sapiens (human)
metal ion binding	DNA topoisomerase 2-beta	Homo sapiens (human)
protein kinase activity	Protein kinase C theta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C theta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C theta type	Homo sapiens (human)
protein binding	Protein kinase C theta type	Homo sapiens (human)
ATP binding	Protein kinase C theta type	Homo sapiens (human)
metal ion binding	Protein kinase C theta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C theta type	Homo sapiens (human)
activin receptor activity, type I	Activin receptor type-1	Homo sapiens (human)
protein kinase activity	Activin receptor type-1	Homo sapiens (human)
protein serine/threonine kinase activity	Activin receptor type-1	Homo sapiens (human)
transmembrane receptor protein serine/threonine kinase activity	Activin receptor type-1	Homo sapiens (human)
protein binding	Activin receptor type-1	Homo sapiens (human)
ATP binding	Activin receptor type-1	Homo sapiens (human)
peptide hormone binding	Activin receptor type-1	Homo sapiens (human)
protein homodimerization activity	Activin receptor type-1	Homo sapiens (human)
cadherin binding	Activin receptor type-1	Homo sapiens (human)
SMAD binding	Activin receptor type-1	Homo sapiens (human)
metal ion binding	Activin receptor type-1	Homo sapiens (human)
activin binding	Activin receptor type-1	Homo sapiens (human)
transforming growth factor beta binding	Activin receptor type-1	Homo sapiens (human)
BMP receptor activity	Activin receptor type-1	Homo sapiens (human)
protein tyrosine kinase binding	Activin receptor type-1	Homo sapiens (human)
transforming growth factor beta receptor activity, type I	Activin receptor type-1	Homo sapiens (human)
macrophage colony-stimulating factor receptor activity	Macrophage-stimulating protein receptor	Homo sapiens (human)
protein binding	Macrophage-stimulating protein receptor	Homo sapiens (human)
ATP binding	Macrophage-stimulating protein receptor	Homo sapiens (human)
enzyme binding	Macrophage-stimulating protein receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Macrophage-stimulating protein receptor	Homo sapiens (human)
actin binding	Focal adhesion kinase 1	Homo sapiens (human)
protein tyrosine kinase activity	Focal adhesion kinase 1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Focal adhesion kinase 1	Homo sapiens (human)
protein tyrosine phosphatase activity	Focal adhesion kinase 1	Homo sapiens (human)
integrin binding	Focal adhesion kinase 1	Homo sapiens (human)
protein binding	Focal adhesion kinase 1	Homo sapiens (human)
ATP binding	Focal adhesion kinase 1	Homo sapiens (human)
JUN kinase binding	Focal adhesion kinase 1	Homo sapiens (human)
protein kinase binding	Focal adhesion kinase 1	Homo sapiens (human)
protein phosphatase binding	Focal adhesion kinase 1	Homo sapiens (human)
SH2 domain binding	Focal adhesion kinase 1	Homo sapiens (human)
molecular function activator activity	Focal adhesion kinase 1	Homo sapiens (human)
protein kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	Protein kinase C delta type	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein binding	Protein kinase C delta type	Homo sapiens (human)
ATP binding	Protein kinase C delta type	Homo sapiens (human)
enzyme activator activity	Protein kinase C delta type	Homo sapiens (human)
enzyme binding	Protein kinase C delta type	Homo sapiens (human)
protein kinase binding	Protein kinase C delta type	Homo sapiens (human)
insulin receptor substrate binding	Protein kinase C delta type	Homo sapiens (human)
metal ion binding	Protein kinase C delta type	Homo sapiens (human)
protein serine kinase activity	Protein kinase C delta type	Homo sapiens (human)
protein tyrosine kinase activity	Tyrosine-protein kinase BTK	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Tyrosine-protein kinase BTK	Homo sapiens (human)
protein binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
ATP binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
phosphatidylinositol-3,4,5-trisphosphate binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
phospholipase activator activity	Tyrosine-protein kinase BTK	Homo sapiens (human)
identical protein binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
phospholipase binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
metal ion binding	Tyrosine-protein kinase BTK	Homo sapiens (human)
protein serine/threonine kinase activity	Activated CDC42 kinase 1	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Activated CDC42 kinase 1	Homo sapiens (human)
protein tyrosine kinase activity	Activated CDC42 kinase 1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Activated CDC42 kinase 1	Homo sapiens (human)
GTPase inhibitor activity	Activated CDC42 kinase 1	Homo sapiens (human)
epidermal growth factor receptor binding	Activated CDC42 kinase 1	Homo sapiens (human)
protein binding	Activated CDC42 kinase 1	Homo sapiens (human)
ATP binding	Activated CDC42 kinase 1	Homo sapiens (human)
ubiquitin protein ligase binding	Activated CDC42 kinase 1	Homo sapiens (human)
identical protein binding	Activated CDC42 kinase 1	Homo sapiens (human)
metal ion binding	Activated CDC42 kinase 1	Homo sapiens (human)
WW domain binding	Activated CDC42 kinase 1	Homo sapiens (human)
protein serine kinase activity	Activated CDC42 kinase 1	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
protein binding	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
collagen binding	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
ATP binding	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
protein tyrosine kinase collagen receptor activity	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
metal ion binding	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
transcription cis-regulatory region binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inward rectifier potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
delayed rectifier potassium channel activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
ubiquitin protein ligase binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
identical protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein homodimerization activity	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
C3HC4-type RING finger domain binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
scaffold protein binding	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
mitogen-activated protein kinase kinase kinase binding	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
MAP kinase kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein homodimerization activity	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein serine/threonine kinase activator activity	Serine/threonine-protein kinase 4	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 4	Homo sapiens (human)
chromatin binding	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein serine/threonine kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
AMP-activated protein kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cAMP-dependent protein kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein binding	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
ATP binding	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
metal ion binding	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
tau protein binding	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
tau-protein kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein serine kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
histone H2BS36 kinase activity	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
protein kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
protein binding	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
ATP binding	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
metal ion binding	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
protein serine kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
MAP kinase kinase activity	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 7	Homo sapiens (human)
enzyme inhibitor activity	Mitogen-activated protein kinase 7	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 7	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 7	Homo sapiens (human)
mitogen-activated protein kinase binding	Mitogen-activated protein kinase 7	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 7	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 7	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein kinase binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein tyrosine kinase activator activity	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cadherin binding	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 3	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activator activity	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
zinc ion binding	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein kinase binding	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Integrin-linked protein kinase	Homo sapiens (human)
protein binding	Integrin-linked protein kinase	Homo sapiens (human)
ATP binding	Integrin-linked protein kinase	Homo sapiens (human)
protein kinase binding	Integrin-linked protein kinase	Homo sapiens (human)
protein serine kinase activity	Integrin-linked protein kinase	Homo sapiens (human)
protein kinase activity	Rho-associated protein kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Rho-associated protein kinase 1	Homo sapiens (human)
protein binding	Rho-associated protein kinase 1	Homo sapiens (human)
ATP binding	Rho-associated protein kinase 1	Homo sapiens (human)
small GTPase binding	Rho-associated protein kinase 1	Homo sapiens (human)
metal ion binding	Rho-associated protein kinase 1	Homo sapiens (human)
tau protein binding	Rho-associated protein kinase 1	Homo sapiens (human)
tau-protein kinase activity	Rho-associated protein kinase 1	Homo sapiens (human)
Rho-dependent protein serine/threonine kinase activity	Rho-associated protein kinase 1	Homo sapiens (human)
protein serine kinase activity	Rho-associated protein kinase 1	Homo sapiens (human)
protein tyrosine kinase activity	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
protein binding	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
ATP binding	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
nucleosomal DNA binding	Histone deacetylase 1	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Histone deacetylase 1	Homo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA binding	Histone deacetylase 1	Homo sapiens (human)
core promoter sequence-specific DNA binding	Histone deacetylase 1	Homo sapiens (human)
transcription corepressor binding	Histone deacetylase 1	Homo sapiens (human)
p53 binding	Histone deacetylase 1	Homo sapiens (human)
transcription corepressor activity	Histone deacetylase 1	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 1	Homo sapiens (human)
protein binding	Histone deacetylase 1	Homo sapiens (human)
enzyme binding	Histone deacetylase 1	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 1	Homo sapiens (human)
Krueppel-associated box domain binding	Histone deacetylase 1	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 1	Homo sapiens (human)
NF-kappaB binding	Histone deacetylase 1	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Histone deacetylase 1	Homo sapiens (human)
E-box binding	Histone deacetylase 1	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 1	Homo sapiens (human)
histone decrotonylase activity	Histone deacetylase 1	Homo sapiens (human)
promoter-specific chromatin binding	Histone deacetylase 1	Homo sapiens (human)
calcium-dependent protein serine/threonine phosphatase activity	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
protein binding	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
identical protein binding	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
protein homodimerization activity	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
protein serine/threonine kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
sodium channel inhibitor activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
titin binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
identical protein binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein homodimerization activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
transmembrane transporter binding	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
protein kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein binding	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
ATP binding	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
identical protein binding	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
tau protein binding	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
tau-protein kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
protein serine kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
histone H3T45 kinase activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
transcription coactivator activity	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
activin receptor activity, type II	Activin receptor type-2B	Homo sapiens (human)
protein serine/threonine kinase activity	Activin receptor type-2B	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Activin receptor type-2B	Homo sapiens (human)
protein binding	Activin receptor type-2B	Homo sapiens (human)
ATP binding	Activin receptor type-2B	Homo sapiens (human)
activin receptor activity, type II	Activin receptor type-2B	Homo sapiens (human)
kinase activator activity	Activin receptor type-2B	Homo sapiens (human)
growth factor binding	Activin receptor type-2B	Homo sapiens (human)
metal ion binding	Activin receptor type-2B	Homo sapiens (human)
activin binding	Activin receptor type-2B	Homo sapiens (human)
activin receptor activity	Activin receptor type-2B	Homo sapiens (human)
protein binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
ATP binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
activin receptor activity, type II	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
growth factor binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
BMP binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cadherin binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
metal ion binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
BMP receptor activity	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
protein tyrosine kinase binding	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
transforming growth factor beta receptor activity	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
protein tyrosine kinase activity	Protein-tyrosine kinase 6	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Protein-tyrosine kinase 6	Homo sapiens (human)
protein binding	Protein-tyrosine kinase 6	Homo sapiens (human)
ATP binding	Protein-tyrosine kinase 6	Homo sapiens (human)
identical protein binding	Protein-tyrosine kinase 6	Homo sapiens (human)
signaling receptor binding	Protein-tyrosine kinase 6	Homo sapiens (human)
protein kinase activity	cGMP-dependent protein kinase 1	Homo sapiens (human)
cGMP-dependent protein kinase activity	cGMP-dependent protein kinase 1	Homo sapiens (human)
calcium channel regulator activity	cGMP-dependent protein kinase 1	Homo sapiens (human)
protein binding	cGMP-dependent protein kinase 1	Homo sapiens (human)
ATP binding	cGMP-dependent protein kinase 1	Homo sapiens (human)
cGMP binding	cGMP-dependent protein kinase 1	Homo sapiens (human)
identical protein binding	cGMP-dependent protein kinase 1	Homo sapiens (human)
mitogen-activated protein kinase p38 binding	cGMP-dependent protein kinase 1	Homo sapiens (human)
protein serine kinase activity	cGMP-dependent protein kinase 1	Homo sapiens (human)
RNA binding	Cyclin-dependent kinase 13	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 13	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 13	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 13	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 13	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Cyclin-dependent kinase 13	Homo sapiens (human)
protein kinase binding	Cyclin-dependent kinase 13	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 13	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 13	Homo sapiens (human)
K63-linked polyubiquitin modification-dependent protein binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
protein serine/threonine kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
protein binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
ATP binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
IkappaB kinase activity	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
protein phosphatase binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
ubiquitin protein ligase binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
K48-linked polyubiquitin modification-dependent protein binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
identical protein binding	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein tyrosine kinase activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
ATP binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
ubiquitin protein ligase binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
glutamate receptor binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
3-phosphoinositide-dependent protein kinase binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein-containing complex binding	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
neurotransmitter receptor regulator activity	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
protein serine/threonine kinase activity	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
non-membrane spanning protein tyrosine kinase activity	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
calcium ion binding	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
protein binding	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
ATP binding	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
lipid binding	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
protein serine kinase activity	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
chromatin binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
RNA binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
protein binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
ATP binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
ATP hydrolysis activity	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
mediator complex binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
protein heterodimerization activity	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
DNA binding	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
nucleosomal DNA binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
transcription coregulator binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
transcription corepressor activity	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
helicase activity	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
protein binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
ATP binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
zinc ion binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
ATP hydrolysis activity	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
histone deacetylase binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
ATP-dependent chromatin remodeler activity	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
chromatin binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
DNA binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
histone binding	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
acyl-CoA oxidase activity	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
protein binding	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
PDZ domain binding	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
protein homodimerization activity	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
FAD binding	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
fatty acid binding	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
flavin adenine dinucleotide binding	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
palmitoyl-CoA oxidase activity	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase 38	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 38	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 38	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 38	Homo sapiens (human)
mitogen-activated protein kinase kinase kinase binding	Serine/threonine-protein kinase 38	Homo sapiens (human)
cadherin binding	Serine/threonine-protein kinase 38	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 38	Homo sapiens (human)
histone reader activity	Serine/threonine-protein kinase 38	Homo sapiens (human)
UFM1-modified protein reader activity	Serine/threonine-protein kinase 38	Homo sapiens (human)
transcription cis-regulatory region binding	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
protein tyrosine kinase activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
epidermal growth factor receptor activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
epidermal growth factor receptor binding	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
protein binding	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
ATP binding	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
neuregulin receptor activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
protein homodimerization activity	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
GABA receptor binding	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
protein tyrosine kinase activity	Ephrin type-A receptor 7	Homo sapiens (human)
GPI-linked ephrin receptor activity	Ephrin type-A receptor 7	Homo sapiens (human)
protein binding	Ephrin type-A receptor 7	Homo sapiens (human)
ATP binding	Ephrin type-A receptor 7	Homo sapiens (human)
axon guidance receptor activity	Ephrin type-A receptor 7	Homo sapiens (human)
growth factor binding	Ephrin type-A receptor 7	Homo sapiens (human)
chemorepellent activity	Ephrin type-A receptor 7	Homo sapiens (human)
transmembrane-ephrin receptor activity	Ephrin type-A receptor 7	Homo sapiens (human)
delta24(24-1) sterol reductase activity	Delta(24)-sterol reductase	Homo sapiens (human)
protein binding	Delta(24)-sterol reductase	Homo sapiens (human)
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Delta(24)-sterol reductase	Homo sapiens (human)
enzyme binding	Delta(24)-sterol reductase	Homo sapiens (human)
peptide antigen binding	Delta(24)-sterol reductase	Homo sapiens (human)
delta24-sterol reductase activity	Delta(24)-sterol reductase	Homo sapiens (human)
FAD binding	Delta(24)-sterol reductase	Homo sapiens (human)
magnesium ion binding	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
protein serine/threonine kinase activity	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
ribosomal protein S6 kinase activity	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
actin binding	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
myosin light chain kinase activity	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
protein binding	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
calmodulin binding	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
ATP binding	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
metal ion binding	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 11	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 11	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 11	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 11	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 11	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
p53 binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
LRR domain binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein kinase activator activity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein-containing complex binding	Serine/threonine-protein kinase STK11	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase STK11	Homo sapiens (human)
chromatin binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein kinase C binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
nuclear receptor coactivator activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
histone H3T11 kinase activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
histone binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
histone deacetylase binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
nuclear androgen receptor binding	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase N1	Homo sapiens (human)
RNA binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase N2	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase N2	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
histone deacetylase binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
cadherin binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
RNA polymerase binding	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 14	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 14	Homo sapiens (human)
MAP kinase kinase activity	Mitogen-activated protein kinase 14	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
enzyme binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
protein phosphatase binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
mitogen-activated protein kinase p38 binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
NFAT protein binding	Mitogen-activated protein kinase 14	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 14	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
calcium-dependent protein serine/threonine kinase activity	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
JUN kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
small GTPase binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
mitogen-activated protein kinase kinase binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
mitogen-activated protein kinase kinase kinase binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
identical protein binding	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein homodimerization activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
protein serine/threonine kinase activity	MAP kinase-activated protein kinase 3	Homo sapiens (human)
MAP kinase kinase activity	MAP kinase-activated protein kinase 3	Homo sapiens (human)
protein binding	MAP kinase-activated protein kinase 3	Homo sapiens (human)
ATP binding	MAP kinase-activated protein kinase 3	Homo sapiens (human)
protein serine kinase activity	MAP kinase-activated protein kinase 3	Homo sapiens (human)
calcium-dependent protein serine/threonine kinase activity	MAP kinase-activated protein kinase 3	Homo sapiens (human)
calmodulin binding	MAP kinase-activated protein kinase 3	Homo sapiens (human)
calmodulin-dependent protein kinase activity	MAP kinase-activated protein kinase 3	Homo sapiens (human)
mitogen-activated protein kinase binding	MAP kinase-activated protein kinase 3	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	Discoidin domain-containing receptor 2	Homo sapiens (human)
protein binding	Discoidin domain-containing receptor 2	Homo sapiens (human)
collagen binding	Discoidin domain-containing receptor 2	Homo sapiens (human)
ATP binding	Discoidin domain-containing receptor 2	Homo sapiens (human)
protein tyrosine kinase collagen receptor activity	Discoidin domain-containing receptor 2	Homo sapiens (human)
protein serine/threonine kinase activity	AP2-associated protein kinase 1	Homo sapiens (human)
Notch binding	AP2-associated protein kinase 1	Homo sapiens (human)
protein binding	AP2-associated protein kinase 1	Homo sapiens (human)
ATP binding	AP2-associated protein kinase 1	Homo sapiens (human)
AP-2 adaptor complex binding	AP2-associated protein kinase 1	Homo sapiens (human)
protein serine kinase activity	AP2-associated protein kinase 1	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Myosin light chain kinase 3	Homo sapiens (human)
myosin light chain kinase activity	Myosin light chain kinase 3	Homo sapiens (human)
protein binding	Myosin light chain kinase 3	Homo sapiens (human)
ATP binding	Myosin light chain kinase 3	Homo sapiens (human)
molecular_function	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
ATP hydrolysis activity	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
ATP-dependent protein folding chaperone	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
disordered domain specific binding	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
ATP binding	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
unfolded protein binding	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
acyl-CoA dehydrogenase activity	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
flavin adenine dinucleotide binding	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase N3	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase N3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase N3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase N3	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase N3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase N3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase N3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
endonuclease activity	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
RNA endonuclease activity	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
unfolded protein binding	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
RNA binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
lipid binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein kinase activator activity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
cadherin binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
tau protein binding	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
tau-protein kinase activity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
chromatin binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
RNA binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
RNA helicase activity	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
double-stranded RNA binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
protein binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
ATP binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
ATP hydrolysis activity	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
G-quadruplex RNA binding	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
DNA helicase activity	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
transferase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
alpha-tubulin binding	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein serine/threonine kinase activator activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
tau protein binding	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
beta-tubulin binding	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
tau-protein kinase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
protein kinase activity	STE20-related kinase adapter protein alpha	Homo sapiens (human)
protein binding	STE20-related kinase adapter protein alpha	Homo sapiens (human)
ATP binding	STE20-related kinase adapter protein alpha	Homo sapiens (human)
kinase binding	STE20-related kinase adapter protein alpha	Homo sapiens (human)
protein kinase activator activity	STE20-related kinase adapter protein alpha	Homo sapiens (human)
protein serine/threonine kinase activator activity	STE20-related kinase adapter protein alpha	Homo sapiens (human)
microfilament motor activity	Myosin-14	Homo sapiens (human)
actin filament binding	Myosin-14	Homo sapiens (human)
calmodulin binding	Myosin-14	Homo sapiens (human)
ATP binding	Myosin-14	Homo sapiens (human)
protein serine/threonine kinase activity	AarF domain-containing protein kinase 1	Homo sapiens (human)
ATP binding	AarF domain-containing protein kinase 1	Homo sapiens (human)
RNA binding	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
RNA helicase activity	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
protein binding	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
ATP binding	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
ATP hydrolysis activity	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
MAP kinase kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
p53 binding	MAP kinase-activated protein kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
MAP kinase kinase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
protein binding	MAP kinase-activated protein kinase 5	Homo sapiens (human)
ATP binding	MAP kinase-activated protein kinase 5	Homo sapiens (human)
protein serine kinase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
calmodulin-dependent protein kinase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
mitogen-activated protein kinase binding	MAP kinase-activated protein kinase 5	Homo sapiens (human)
calcium-dependent protein serine/threonine kinase activity	MAP kinase-activated protein kinase 5	Homo sapiens (human)
calmodulin binding	MAP kinase-activated protein kinase 5	Homo sapiens (human)
RNA binding	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
translation release factor activity	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
GTPase activity	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
protein binding	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
GTP binding	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
protein kinase activity	Misshapen-like kinase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Misshapen-like kinase 1	Homo sapiens (human)
protein binding	Misshapen-like kinase 1	Homo sapiens (human)
ATP binding	Misshapen-like kinase 1	Homo sapiens (human)
protein serine kinase activity	Misshapen-like kinase 1	Homo sapiens (human)
protein kinase activity	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
protein binding	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
ATP binding	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
kinase activity	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
ADP binding	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
protein binding	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
ATP binding	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
1-phosphatidylinositol-4-phosphate 5-kinase activity	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
identical protein binding	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
1-phosphatidylinositol-5-phosphate 4-kinase activity	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
chromatin binding	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
MAP kinase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase 15	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase 15	Homo sapiens (human)
kinase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
SH3 domain binding	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase 15	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein kinase binding	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein kinase activator activity	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
molecular function activator activity	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
chromatin binding	Histone deacetylase 7	Homo sapiens (human)
transcription corepressor activity	Histone deacetylase 7	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 7	Homo sapiens (human)
protein kinase C binding	Histone deacetylase 7	Homo sapiens (human)
protein binding	Histone deacetylase 7	Homo sapiens (human)
SUMO transferase activity	Histone deacetylase 7	Homo sapiens (human)
protein kinase binding	Histone deacetylase 7	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 7	Homo sapiens (human)
metal ion binding	Histone deacetylase 7	Homo sapiens (human)
14-3-3 protein binding	Histone deacetylase 7	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 7	Homo sapiens (human)
DNA binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
chromatin binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
transcription coregulator activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
RNA binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
RNA helicase activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
double-stranded RNA binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
nuclease activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
exonuclease activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
protein binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
ATP binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
poly(A) binding	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
ATP hydrolysis activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
DNA/RNA helicase activity	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol heptakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
protein binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
ATP binding	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 1-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol hexakisphosphate 3-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activity	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleosomal DNA binding	Histone deacetylase 2	Homo sapiens (human)
chromatin binding	Histone deacetylase 2	Homo sapiens (human)
RNA binding	Histone deacetylase 2	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 2	Homo sapiens (human)
protein binding	Histone deacetylase 2	Homo sapiens (human)
enzyme binding	Histone deacetylase 2	Homo sapiens (human)
heat shock protein binding	Histone deacetylase 2	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 2	Homo sapiens (human)
histone binding	Histone deacetylase 2	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 2	Homo sapiens (human)
NF-kappaB binding	Histone deacetylase 2	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Histone deacetylase 2	Homo sapiens (human)
histone decrotonylase activity	Histone deacetylase 2	Homo sapiens (human)
protein de-2-hydroxyisobutyrylase activity	Histone deacetylase 2	Homo sapiens (human)
promoter-specific chromatin binding	Histone deacetylase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
MAP kinase kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
protein lysine deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
histone deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
protein binding	Polyamine deacetylase HDAC10	Homo sapiens (human)
zinc ion binding	Polyamine deacetylase HDAC10	Homo sapiens (human)
deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
enzyme binding	Polyamine deacetylase HDAC10	Homo sapiens (human)
protein lysine deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
histone deacetylase binding	Polyamine deacetylase HDAC10	Homo sapiens (human)
acetylputrescine deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
acetylspermidine deacetylase activity	Polyamine deacetylase HDAC10	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 11	Homo sapiens (human)
protein binding	Histone deacetylase 11	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 11	Homo sapiens (human)
protein serine/threonine kinase activity	Aurora kinase B	Homo sapiens (human)
protein serine/threonine kinase activity	Aurora kinase B	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Aurora kinase B	Homo sapiens (human)
protein binding	Aurora kinase B	Homo sapiens (human)
ATP binding	Aurora kinase B	Homo sapiens (human)
kinase binding	Aurora kinase B	Homo sapiens (human)
protein serine kinase activity	Aurora kinase B	Homo sapiens (human)
protein serine/threonine kinase activity	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
protein binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
ATP binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
microtubule binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cytoskeletal anchor activity	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
gamma-tubulin binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
ubiquitin binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
tau protein binding	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
tau-protein kinase activity	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
protein serine kinase activity	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
protein binding	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
protein tyrosine kinase activity	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
kinase activity	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
14-3-3 protein binding	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
calmodulin-dependent protein kinase activity	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein tyrosine kinase activity	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
calcium ion binding	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
calmodulin binding	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
ATP binding	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein serine kinase activity	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
p53 binding	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
protein serine/threonine kinase activity	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
protein binding	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
ATP binding	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
hydrolase activity	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
protein serine kinase activity	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
protein kinase activity	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein binding	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
ATP binding	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
metal ion binding	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein serine kinase activity	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
protein binding	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
ATP binding	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
kinase activity	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
metal ion binding	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
protein serine kinase activity	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
protein kinase activity	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
magnesium ion binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
JUN kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein kinase binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein phosphatase binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein domain specific binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
identical protein binding	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein homodimerization activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
metal ion binding	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
eukaryotic translation initiation factor 2alpha kinase activity	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
protein binding	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
ATP binding	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
heme binding	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
protein homodimerization activity	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
protein serine kinase activity	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 8	Homo sapiens (human)
protein binding	Histone deacetylase 8	Homo sapiens (human)
Hsp70 protein binding	Histone deacetylase 8	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 8	Homo sapiens (human)
metal ion binding	Histone deacetylase 8	Homo sapiens (human)
Hsp90 protein binding	Histone deacetylase 8	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 8	Homo sapiens (human)
histone decrotonylase activity	Histone deacetylase 8	Homo sapiens (human)
RNA binding	Nucleolar GTP-binding protein 1	Homo sapiens (human)
GTPase activity	Nucleolar GTP-binding protein 1	Homo sapiens (human)
protein binding	Nucleolar GTP-binding protein 1	Homo sapiens (human)
GTP binding	Nucleolar GTP-binding protein 1	Homo sapiens (human)
preribosome binding	Nucleolar GTP-binding protein 1	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
diacylglycerol-dependent serine/threonine kinase activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein kinase C binding	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase D2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase D2	Homo sapiens (human)
metal ion binding	Serine/threonine-protein kinase D2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase D2	Homo sapiens (human)
magnesium ion binding	NUAK family SNF1-like kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	NUAK family SNF1-like kinase 2	Homo sapiens (human)
protein binding	NUAK family SNF1-like kinase 2	Homo sapiens (human)
ATP binding	NUAK family SNF1-like kinase 2	Homo sapiens (human)
protein serine kinase activity	NUAK family SNF1-like kinase 2	Homo sapiens (human)
RNA binding	RNA cytidine acetyltransferase	Homo sapiens (human)
protein binding	RNA cytidine acetyltransferase	Homo sapiens (human)
ATP binding	RNA cytidine acetyltransferase	Homo sapiens (human)
N-acetyltransferase activity	RNA cytidine acetyltransferase	Homo sapiens (human)
tRNA N-acetyltransferase activity	RNA cytidine acetyltransferase	Homo sapiens (human)
DNA polymerase binding	RNA cytidine acetyltransferase	Homo sapiens (human)
mRNA N-acetyltransferase activity	RNA cytidine acetyltransferase	Homo sapiens (human)
tRNA binding	RNA cytidine acetyltransferase	Homo sapiens (human)
rRNA cytidine N-acetyltransferase activity	RNA cytidine acetyltransferase	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
protein serine/threonine kinase activity	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein binding	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
identical protein binding	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein homodimerization activity	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
cadherin binding	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
protein kinase inhibitor activity	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
transferase activity	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
magnesium ion binding	dCTP pyrophosphatase 1	Homo sapiens (human)
protein binding	dCTP pyrophosphatase 1	Homo sapiens (human)
pyrimidine deoxyribonucleotide binding	dCTP pyrophosphatase 1	Homo sapiens (human)
identical protein binding	dCTP pyrophosphatase 1	Homo sapiens (human)
nucleoside triphosphate diphosphatase activity	dCTP pyrophosphatase 1	Homo sapiens (human)
dCTP diphosphatase activity	dCTP pyrophosphatase 1	Homo sapiens (human)
protein serine/threonine kinase activity	Dual specificity protein kinase CLK4	Homo sapiens (human)
protein serine/threonine/tyrosine kinase activity	Dual specificity protein kinase CLK4	Homo sapiens (human)
protein binding	Dual specificity protein kinase CLK4	Homo sapiens (human)
ATP binding	Dual specificity protein kinase CLK4	Homo sapiens (human)
protein serine kinase activity	Dual specificity protein kinase CLK4	Homo sapiens (human)
protein tyrosine kinase activity	Dual specificity protein kinase CLK4	Homo sapiens (human)
molecular_function	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
protein binding	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
alpha-tubulin binding	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
beta-tubulin binding	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule binding	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform gamma-1	Homo sapiens (human)
protein binding	Casein kinase I isoform gamma-1	Homo sapiens (human)
ATP binding	Casein kinase I isoform gamma-1	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform gamma-1	Homo sapiens (human)
magnesium ion binding	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
RNA binding	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
phenylalanine-tRNA ligase activity	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
protein binding	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
ATP binding	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
tRNA binding	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
aminoacyl-tRNA editing activity	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
isoleucine-tRNA ligase activity	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
ATP binding	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
protein binding	BMP-2-inducible protein kinase	Homo sapiens (human)
ATP binding	BMP-2-inducible protein kinase	Homo sapiens (human)
protein serine kinase activity	BMP-2-inducible protein kinase	Homo sapiens (human)
phosphatase regulator activity	BMP-2-inducible protein kinase	Homo sapiens (human)
AP-2 adaptor complex binding	BMP-2-inducible protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	BMP-2-inducible protein kinase	Homo sapiens (human)
protein binding	Obg-like ATPase 1	Homo sapiens (human)
ATP binding	Obg-like ATPase 1	Homo sapiens (human)
GTP binding	Obg-like ATPase 1	Homo sapiens (human)
ATP hydrolysis activity	Obg-like ATPase 1	Homo sapiens (human)
ribosomal large subunit binding	Obg-like ATPase 1	Homo sapiens (human)
cadherin binding	Obg-like ATPase 1	Homo sapiens (human)
metal ion binding	Obg-like ATPase 1	Homo sapiens (human)
protein binding	Midasin	Homo sapiens (human)
ATP binding	Midasin	Homo sapiens (human)
ATP hydrolysis activity	Midasin	Homo sapiens (human)
magnesium ion binding	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
protein serine/threonine kinase activity	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
interleukin-1 receptor binding	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
protein binding	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
ATP binding	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
kinase activity	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
protein kinase binding	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
protein serine kinase activity	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
magnesium ion binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
RNA binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
JUN kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein kinase activator activity	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
ribosome binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
small ribosomal subunit rRNA binding	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
protein kinase activity	Cyclin-dependent kinase 12	Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activity	Cyclin-dependent kinase 12	Homo sapiens (human)
protein binding	Cyclin-dependent kinase 12	Homo sapiens (human)
ATP binding	Cyclin-dependent kinase 12	Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activity	Cyclin-dependent kinase 12	Homo sapiens (human)
protein kinase binding	Cyclin-dependent kinase 12	Homo sapiens (human)
cyclin binding	Cyclin-dependent kinase 12	Homo sapiens (human)
protein serine kinase activity	Cyclin-dependent kinase 12	Homo sapiens (human)
protein binding	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
ATP binding	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
endopeptidase activator activity	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase 26	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase 26	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein homodimerization activity	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase 26	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase 26	Homo sapiens (human)
magnesium ion binding	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinate-CoA ligase (ADP-forming) activity	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
protein binding	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
ATP binding	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase NLK	Homo sapiens (human)
MAP kinase activity	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
ubiquitin protein ligase binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
SH2 domain binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase NLK	Homo sapiens (human)
DNA-binding transcription factor binding	Serine/threonine-protein kinase NLK	Homo sapiens (human)
acetylspermidine deacetylase activity	Histone deacetylase 6	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Histone deacetylase 6	Homo sapiens (human)
transcription corepressor binding	Histone deacetylase 6	Homo sapiens (human)
actin binding	Histone deacetylase 6	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 6	Homo sapiens (human)
protein binding	Histone deacetylase 6	Homo sapiens (human)
beta-catenin binding	Histone deacetylase 6	Homo sapiens (human)
microtubule binding	Histone deacetylase 6	Homo sapiens (human)
zinc ion binding	Histone deacetylase 6	Homo sapiens (human)
enzyme binding	Histone deacetylase 6	Homo sapiens (human)
polyubiquitin modification-dependent protein binding	Histone deacetylase 6	Homo sapiens (human)
ubiquitin protein ligase binding	Histone deacetylase 6	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 6	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 6	Homo sapiens (human)
tubulin deacetylase activity	Histone deacetylase 6	Homo sapiens (human)
alpha-tubulin binding	Histone deacetylase 6	Homo sapiens (human)
ubiquitin binding	Histone deacetylase 6	Homo sapiens (human)
tau protein binding	Histone deacetylase 6	Homo sapiens (human)
beta-tubulin binding	Histone deacetylase 6	Homo sapiens (human)
misfolded protein binding	Histone deacetylase 6	Homo sapiens (human)
Hsp90 protein binding	Histone deacetylase 6	Homo sapiens (human)
dynein complex binding	Histone deacetylase 6	Homo sapiens (human)
transcription factor binding	Histone deacetylase 6	Homo sapiens (human)
AMP-activated protein kinase activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cAMP-dependent protein kinase inhibitor activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
protein binding	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
ATP binding	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cAMP-dependent protein kinase regulator activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
phosphorylase kinase regulator activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
protein kinase regulator activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
protein kinase binding	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
protein kinase activator activity	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
ADP binding	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
AMP binding	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
nucleic acid binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein phosphatase binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
identical protein binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
phosphoprotein binding	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
protein binding	Septin-9	Homo sapiens (human)
GTP binding	Septin-9	Homo sapiens (human)
cadherin binding	Septin-9	Homo sapiens (human)
GTPase activity	Septin-9	Homo sapiens (human)
molecular adaptor activity	Septin-9	Homo sapiens (human)
magnesium ion binding	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
protein kinase activity	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
protein binding	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
ATP binding	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
protein serine kinase activity	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
ribosomal protein S6 kinase activity	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
protein kinase activity	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein binding	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
ATP binding	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
protein serine kinase activity	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
transcription corepressor activity	Histone deacetylase 9	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 9	Homo sapiens (human)
protein kinase C binding	Histone deacetylase 9	Homo sapiens (human)
protein binding	Histone deacetylase 9	Homo sapiens (human)
histone H3K14 deacetylase activity	Histone deacetylase 9	Homo sapiens (human)
histone H3K9 deacetylase activity	Histone deacetylase 9	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 9	Homo sapiens (human)
histone H4K16 deacetylase activity	Histone deacetylase 9	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 9	Homo sapiens (human)
metal ion binding	Histone deacetylase 9	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Histone deacetylase 9	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 9	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
MAP kinase kinase kinase activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
mitogen-activated protein kinase kinase binding	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
neuropilin binding	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein serine/threonine kinase activator activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
tau protein binding	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
tau-protein kinase activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
protein tyrosine kinase activity	ALK tyrosine kinase receptor	Homo sapiens (human)
transmembrane receptor protein tyrosine kinase activity	ALK tyrosine kinase receptor	Homo sapiens (human)
protein binding	ALK tyrosine kinase receptor	Homo sapiens (human)
ATP binding	ALK tyrosine kinase receptor	Homo sapiens (human)
heparin binding	ALK tyrosine kinase receptor	Homo sapiens (human)
receptor signaling protein tyrosine kinase activator activity	ALK tyrosine kinase receptor	Homo sapiens (human)
identical protein binding	ALK tyrosine kinase receptor	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase ICK	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase ICK	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase ICK	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase ICK	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase ICK	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase ICK	Homo sapiens (human)
transcription cis-regulatory region binding	Histone deacetylase 5	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Histone deacetylase 5	Homo sapiens (human)
transcription corepressor binding	Histone deacetylase 5	Homo sapiens (human)
chromatin binding	Histone deacetylase 5	Homo sapiens (human)
histone deacetylase activity	Histone deacetylase 5	Homo sapiens (human)
protein kinase C binding	Histone deacetylase 5	Homo sapiens (human)
protein binding	Histone deacetylase 5	Homo sapiens (human)
protein lysine deacetylase activity	Histone deacetylase 5	Homo sapiens (human)
identical protein binding	Histone deacetylase 5	Homo sapiens (human)
histone deacetylase binding	Histone deacetylase 5	Homo sapiens (human)
metal ion binding	Histone deacetylase 5	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Histone deacetylase 5	Homo sapiens (human)
DNA-binding transcription factor binding	Histone deacetylase 5	Homo sapiens (human)
protein kinase activity	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
protein serine/threonine kinase activity	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
protein binding	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
ATP binding	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
protein serine kinase activity	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
protein binding	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
tau-protein kinase activity	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
protein kinase binding	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
metal ion binding	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
transcription coregulator activity	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
transcription coactivator activity	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
RNA binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
protein binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
ATP binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nuclear receptor coactivator activity	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nuclear vitamin D receptor binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nuclear thyroid hormone receptor binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
phosphoprotein binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
DNA binding	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
protein kinase activity	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
protein serine/threonine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
MAP kinase kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
transcription coactivator activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein kinase activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein binding	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
ATP binding	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
identical protein binding	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein-containing complex binding	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein serine kinase activity	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
magnesium ion binding	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
protein kinase activity	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
protein serine/threonine kinase activity	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
ATP binding	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
small GTPase binding	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
protein-containing complex binding	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
protein serine kinase activity	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
magnesium ion binding	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein serine/threonine kinase activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein binding	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
ATP binding	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein kinase binding	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein homodimerization activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein heterodimerization activity	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
protein kinase activity	Casein kinase I isoform gamma-3	Homo sapiens (human)
protein serine/threonine kinase activity	Casein kinase I isoform gamma-3	Homo sapiens (human)
ATP binding	Casein kinase I isoform gamma-3	Homo sapiens (human)
protein serine kinase activity	Casein kinase I isoform gamma-3	Homo sapiens (human)
MAP kinase kinase kinase activity	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
protein binding	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
ATP binding	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
metal ion binding	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
protein serine kinase activity	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (414)

Process	via Protein(s)	Taxonomy
plasma membrane	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
dendrite	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
neuronal cell body	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
receptor complex	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
HFE-transferrin receptor complex	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
plasma membrane	Bone morphogenetic protein receptor type-1B	Homo sapiens (human)
plasma membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
extracellular region	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
mitochondrial outer membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
endoplasmic reticulum	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
plasma membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
smooth endoplasmic reticulum membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
specific granule membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
neuron projection	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
neuronal cell body	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
cell body	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
synapse	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
endoplasmic reticulum	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
endomembrane system	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
membrane	Membrane-associated progesterone receptor component 1	Homo sapiens (human)
XY body	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
nucleolus	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
centriole	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
cleavage furrow	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
deuterosome	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
procentriole	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
procentriole replication complex	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase PLK4	Homo sapiens (human)
eukaryotic translation initiation factor 3 complex	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytosolic small ribosomal subunit	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
extracellular region	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
nucleoplasm	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
centrosome	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytosol	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
plasma membrane	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cytoplasmic stress granule	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
lamellipodium	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
cell leading edge	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
secretory granule lumen	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
extracellular exosome	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
ficolin-1-rich granule lumen	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
NLRP3 inflammasome complex	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
P granule	ATP-dependent RNA helicase DDX3X	Homo sapiens (human)
extracellular region	Pyridoxal kinase	Homo sapiens (human)
nucleus	Pyridoxal kinase	Homo sapiens (human)
nucleoplasm	Pyridoxal kinase	Homo sapiens (human)
cytosol	Pyridoxal kinase	Homo sapiens (human)
secretory granule lumen	Pyridoxal kinase	Homo sapiens (human)
specific granule lumen	Pyridoxal kinase	Homo sapiens (human)
extracellular exosome	Pyridoxal kinase	Homo sapiens (human)
cytosol	Pyridoxal kinase	Homo sapiens (human)
cytosol	Citron Rho-interacting kinase	Homo sapiens (human)
membrane	Citron Rho-interacting kinase	Homo sapiens (human)
chromosome, telomeric region	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
condensed nuclear chromosome	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
extracellular space	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
replication fork	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
intracellular membrane-bounded organelle	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
chromatin	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Chk1	Homo sapiens (human)
spindle microtubule	Aurora kinase A	Homo sapiens (human)
nucleus	Aurora kinase A	Homo sapiens (human)
nucleoplasm	Aurora kinase A	Homo sapiens (human)
centrosome	Aurora kinase A	Homo sapiens (human)
centriole	Aurora kinase A	Homo sapiens (human)
spindle	Aurora kinase A	Homo sapiens (human)
cytosol	Aurora kinase A	Homo sapiens (human)
postsynaptic density	Aurora kinase A	Homo sapiens (human)
microtubule cytoskeleton	Aurora kinase A	Homo sapiens (human)
basolateral plasma membrane	Aurora kinase A	Homo sapiens (human)
midbody	Aurora kinase A	Homo sapiens (human)
spindle pole centrosome	Aurora kinase A	Homo sapiens (human)
ciliary basal body	Aurora kinase A	Homo sapiens (human)
germinal vesicle	Aurora kinase A	Homo sapiens (human)
axon hillock	Aurora kinase A	Homo sapiens (human)
pronucleus	Aurora kinase A	Homo sapiens (human)
perinuclear region of cytoplasm	Aurora kinase A	Homo sapiens (human)
mitotic spindle	Aurora kinase A	Homo sapiens (human)
meiotic spindle	Aurora kinase A	Homo sapiens (human)
mitotic spindle pole	Aurora kinase A	Homo sapiens (human)
glutamatergic synapse	Aurora kinase A	Homo sapiens (human)
spindle pole centrosome	Aurora kinase A	Homo sapiens (human)
chromosome passenger complex	Aurora kinase A	Homo sapiens (human)
spindle midzone	Aurora kinase A	Homo sapiens (human)
kinetochore	Aurora kinase A	Homo sapiens (human)
Golgi apparatus	Cyclin-G-associated kinase	Homo sapiens (human)
cytosol	Cyclin-G-associated kinase	Homo sapiens (human)
focal adhesion	Cyclin-G-associated kinase	Homo sapiens (human)
membrane	Cyclin-G-associated kinase	Homo sapiens (human)
clathrin-coated vesicle	Cyclin-G-associated kinase	Homo sapiens (human)
vesicle	Cyclin-G-associated kinase	Homo sapiens (human)
intracellular membrane-bounded organelle	Cyclin-G-associated kinase	Homo sapiens (human)
perinuclear region of cytoplasm	Cyclin-G-associated kinase	Homo sapiens (human)
presynapse	Cyclin-G-associated kinase	Homo sapiens (human)
vesicle	Cyclin-G-associated kinase	Homo sapiens (human)
cytoplasm	Cyclin-G-associated kinase	Homo sapiens (human)
intracellular membrane-bounded organelle	Cyclin-G-associated kinase	Homo sapiens (human)
extracellular region	Ephrin type-B receptor 6	Homo sapiens (human)
cytosol	Ephrin type-B receptor 6	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 6	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 6	Homo sapiens (human)
dendrite	Ephrin type-B receptor 6	Homo sapiens (human)
peroxisome	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
peroxisomal matrix	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
cytosol	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
membrane	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
peroxisome	Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)
nucleus	Histone deacetylase 3	Homo sapiens (human)
nucleoplasm	Histone deacetylase 3	Homo sapiens (human)
cytoplasm	Histone deacetylase 3	Homo sapiens (human)
Golgi apparatus	Histone deacetylase 3	Homo sapiens (human)
cytosol	Histone deacetylase 3	Homo sapiens (human)
plasma membrane	Histone deacetylase 3	Homo sapiens (human)
mitotic spindle	Histone deacetylase 3	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 3	Homo sapiens (human)
transcription repressor complex	Histone deacetylase 3	Homo sapiens (human)
nucleus	Histone deacetylase 3	Homo sapiens (human)
plasma membrane	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cytoplasm	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
endoplasmic reticulum	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cytosol	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
cytoskeleton	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
vesicle	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
protein-containing complex	Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)
kinetochore	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
nucleoplasm	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
cytosol	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
membrane	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
intracellular membrane-bounded organelle	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
outer kinetochore	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
kinetochore	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
nucleus	Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)
nucleoplasm	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrion	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial outer membrane	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial intermembrane space	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
cytosol	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
membrane	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial crista	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
dendrite	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
axon cytoplasm	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial intermembrane space	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
cytoplasm	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
microtubule	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
mitochondrial membrane	Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)
chromatin	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	Lysine-specific histone demethylase 1A	Homo sapiens (human)
chromosome, telomeric region	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleoplasm	Lysine-specific histone demethylase 1A	Homo sapiens (human)
transcription regulator complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
protein-containing complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
DNA repair complex	Lysine-specific histone demethylase 1A	Homo sapiens (human)
nucleus	Putative nucleoside diphosphate kinase	Homo sapiens (human)
extracellular exosome	Putative nucleoside diphosphate kinase	Homo sapiens (human)
nucleus	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
cytoplasm	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
cytosol	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
synapse	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
cytoplasm	Eukaryotic translation initiation factor 5B	Homo sapiens (human)
nucleus	Rho-associated protein kinase 2	Homo sapiens (human)
centrosome	Rho-associated protein kinase 2	Homo sapiens (human)
cytosol	Rho-associated protein kinase 2	Homo sapiens (human)
plasma membrane	Rho-associated protein kinase 2	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Rho-associated protein kinase 2	Homo sapiens (human)
centrosome	Rho-associated protein kinase 2	Homo sapiens (human)
cytoskeleton	Rho-associated protein kinase 2	Homo sapiens (human)
cytoplasm	Rho-associated protein kinase 2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
phagophore assembly site	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
autophagosome membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
mitochondrial outer membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
autophagosome	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
axon	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
phagophore assembly site membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
recycling endosome	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
omegasome membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
Atg1/ULK1 kinase complex	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
phagophore assembly site	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
autophagosome	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
phagophore assembly site membrane	Serine/threonine-protein kinase ULK1	Homo sapiens (human)
nuclear inner membrane	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
mitochondrion	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
endoplasmic reticulum	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
Ire1 complex	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
AIP1-IRE1 complex	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
IRE1-TRAF2-ASK1 complex	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
IRE1-RACK1-PP2A complex	Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)
nucleus	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)
nucleus	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
nucleoplasm	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
membrane	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U4/U6 x U5 tri-snRNP complex	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
spliceosomal complex	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U5 snRNP	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U2-type precatalytic spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
U2-type catalytic step 1 spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
catalytic step 2 spliceosome	U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)
nucleus	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
cytosol	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
synapse	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase 16	Homo sapiens (human)
Golgi-associated vesicle	Serine/threonine-protein kinase 16	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 16	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase 16	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase 16	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase 16	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 16	Homo sapiens (human)
ruffle membrane	Cyclin-dependent kinase-like 5	Homo sapiens (human)
glutamatergic synapse	Cyclin-dependent kinase-like 5	Homo sapiens (human)
nucleus	Cyclin-dependent kinase-like 5	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase-like 5	Homo sapiens (human)
centrosome	Cyclin-dependent kinase-like 5	Homo sapiens (human)
dendrite cytoplasm	Cyclin-dependent kinase-like 5	Homo sapiens (human)
ciliary basal body	Cyclin-dependent kinase-like 5	Homo sapiens (human)
dendritic growth cone	Cyclin-dependent kinase-like 5	Homo sapiens (human)
perinuclear region of cytoplasm	Cyclin-dependent kinase-like 5	Homo sapiens (human)
ciliary tip	Cyclin-dependent kinase-like 5	Homo sapiens (human)
postsynaptic density, intracellular component	Cyclin-dependent kinase-like 5	Homo sapiens (human)
nucleus	Cyclin-dependent kinase-like 5	Homo sapiens (human)
dendrite cytoplasm	Cyclin-dependent kinase-like 5	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 10	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase 10	Homo sapiens (human)
specific granule membrane	Serine/threonine-protein kinase 10	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase 10	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 10	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase D3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D3	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase D3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D3	Homo sapiens (human)
nuclear chromosome	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
condensed chromosome	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
condensed nuclear chromosome	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
condensin complex	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
nucleus	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
nucleoplasm	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
nucleolus	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
cytoplasm	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
cytosol	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
extracellular exosome	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
condensed chromosome	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
chromatin	Structural maintenance of chromosomes protein 2	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
focal adhesion	Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
spindle pole	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
midbody	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
spindle pole	Serine/threonine-protein kinase LATS1	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
adherens junction	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
focal adhesion	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase PAK 4	Homo sapiens (human)
ruffle	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nucleus	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nucleoplasm	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nucleolus	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase ABL1	Homo sapiens (human)
mitochondrion	Tyrosine-protein kinase ABL1	Homo sapiens (human)
cytosol	Tyrosine-protein kinase ABL1	Homo sapiens (human)
actin cytoskeleton	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nuclear body	Tyrosine-protein kinase ABL1	Homo sapiens (human)
dendrite	Tyrosine-protein kinase ABL1	Homo sapiens (human)
growth cone	Tyrosine-protein kinase ABL1	Homo sapiens (human)
nuclear membrane	Tyrosine-protein kinase ABL1	Homo sapiens (human)
neuronal cell body	Tyrosine-protein kinase ABL1	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosine-protein kinase ABL1	Homo sapiens (human)
postsynapse	Tyrosine-protein kinase ABL1	Homo sapiens (human)
protein-containing complex	Tyrosine-protein kinase ABL1	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase ABL1	Homo sapiens (human)
endosome	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
ruffle membrane	Epidermal growth factor receptor	Homo sapiens (human)
Golgi membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular space	Epidermal growth factor receptor	Homo sapiens (human)
nucleus	Epidermal growth factor receptor	Homo sapiens (human)
cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
endosome	Epidermal growth factor receptor	Homo sapiens (human)
endoplasmic reticulum membrane	Epidermal growth factor receptor	Homo sapiens (human)
plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
focal adhesion	Epidermal growth factor receptor	Homo sapiens (human)
cell surface	Epidermal growth factor receptor	Homo sapiens (human)
endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane	Epidermal growth factor receptor	Homo sapiens (human)
basolateral plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
apical plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
cell junction	Epidermal growth factor receptor	Homo sapiens (human)
clathrin-coated endocytic vesicle membrane	Epidermal growth factor receptor	Homo sapiens (human)
early endosome membrane	Epidermal growth factor receptor	Homo sapiens (human)
nuclear membrane	Epidermal growth factor receptor	Homo sapiens (human)
membrane raft	Epidermal growth factor receptor	Homo sapiens (human)
perinuclear region of cytoplasm	Epidermal growth factor receptor	Homo sapiens (human)
multivesicular body, internal vesicle lumen	Epidermal growth factor receptor	Homo sapiens (human)
intracellular vesicle	Epidermal growth factor receptor	Homo sapiens (human)
protein-containing complex	Epidermal growth factor receptor	Homo sapiens (human)
receptor complex	Epidermal growth factor receptor	Homo sapiens (human)
Shc-EGFR complex	Epidermal growth factor receptor	Homo sapiens (human)
basal plasma membrane	Epidermal growth factor receptor	Homo sapiens (human)
extracellular space	Interferon beta	Homo sapiens (human)
extracellular region	Interferon beta	Homo sapiens (human)
Golgi membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
endoplasmic reticulum	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
Golgi apparatus	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
cell surface	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
ER to Golgi transport vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
secretory granule membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
phagocytic vesicle membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
early endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
recycling endosome membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular exosome	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
lumenal side of endoplasmic reticulum membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
MHC class I protein complex	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
extracellular space	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
external side of plasma membrane	HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)
semaphorin receptor complex	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
nucleus	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
nucleoplasm	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
early endosome	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
cytosol	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
endosome membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
basolateral plasma membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
apical plasma membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
neuromuscular junction	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ruffle membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
presynaptic membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
myelin sheath	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
perinuclear region of cytoplasm	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
ERBB3:ERBB2 complex	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
receptor complex	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
basal plasma membrane	Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)
early endosome	High affinity nerve growth factor receptor	Homo sapiens (human)
late endosome	High affinity nerve growth factor receptor	Homo sapiens (human)
plasma membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
cell surface	High affinity nerve growth factor receptor	Homo sapiens (human)
endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
dendrite	High affinity nerve growth factor receptor	Homo sapiens (human)
early endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
late endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
neuronal cell body	High affinity nerve growth factor receptor	Homo sapiens (human)
recycling endosome membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
protein-containing complex	High affinity nerve growth factor receptor	Homo sapiens (human)
receptor complex	High affinity nerve growth factor receptor	Homo sapiens (human)
axon	High affinity nerve growth factor receptor	Homo sapiens (human)
plasma membrane	High affinity nerve growth factor receptor	Homo sapiens (human)
nucleoplasm	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cytoplasm	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
centrosome	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cytosol	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
plasma membrane	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
membrane	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
dendrite	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
midbody	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cell body	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
synapse	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
extracellular exosome	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
neuronal dense core vesicle	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
extracellular vesicle	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
heterotrimeric G-protein complex	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
cytoplasm	Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)
nucleus	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrion	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrial inner membrane	ADP/ATP translocase 2	Homo sapiens (human)
plasma membrane	ADP/ATP translocase 2	Homo sapiens (human)
membrane	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrial nucleoid	ADP/ATP translocase 2	Homo sapiens (human)
mitochondrial permeability transition pore complex	ADP/ATP translocase 2	Homo sapiens (human)
MMXD complex	ADP/ATP translocase 2	Homo sapiens (human)
nucleus	Protein kinase C beta type	Homo sapiens (human)
nucleoplasm	Protein kinase C beta type	Homo sapiens (human)
cytoplasm	Protein kinase C beta type	Homo sapiens (human)
centrosome	Protein kinase C beta type	Homo sapiens (human)
cytosol	Protein kinase C beta type	Homo sapiens (human)
plasma membrane	Protein kinase C beta type	Homo sapiens (human)
brush border membrane	Protein kinase C beta type	Homo sapiens (human)
calyx of Held	Protein kinase C beta type	Homo sapiens (human)
extracellular exosome	Protein kinase C beta type	Homo sapiens (human)
presynaptic cytosol	Protein kinase C beta type	Homo sapiens (human)
spectrin	Protein kinase C beta type	Homo sapiens (human)
nuclear envelope	Insulin receptor	Homo sapiens (human)
nuclear lumen	Insulin receptor	Homo sapiens (human)
lysosome	Insulin receptor	Homo sapiens (human)
late endosome	Insulin receptor	Homo sapiens (human)
plasma membrane	Insulin receptor	Homo sapiens (human)
caveola	Insulin receptor	Homo sapiens (human)
external side of plasma membrane	Insulin receptor	Homo sapiens (human)
endosome membrane	Insulin receptor	Homo sapiens (human)
membrane	Insulin receptor	Homo sapiens (human)
dendrite membrane	Insulin receptor	Homo sapiens (human)
neuronal cell body membrane	Insulin receptor	Homo sapiens (human)
extracellular exosome	Insulin receptor	Homo sapiens (human)
insulin receptor complex	Insulin receptor	Homo sapiens (human)
receptor complex	Insulin receptor	Homo sapiens (human)
plasma membrane	Insulin receptor	Homo sapiens (human)
axon	Insulin receptor	Homo sapiens (human)
pericentriolar material	Tyrosine-protein kinase Lck	Homo sapiens (human)
immunological synapse	Tyrosine-protein kinase Lck	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Lck	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lck	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Lck	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase Lck	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lck	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite	Tyrosine-protein kinase Fyn	Homo sapiens (human)
nucleus	Tyrosine-protein kinase Fyn	Homo sapiens (human)
mitochondrion	Tyrosine-protein kinase Fyn	Homo sapiens (human)
endosome	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Fyn	Homo sapiens (human)
actin filament	Tyrosine-protein kinase Fyn	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
postsynaptic density	Tyrosine-protein kinase Fyn	Homo sapiens (human)
dendrite	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perikaryon	Tyrosine-protein kinase Fyn	Homo sapiens (human)
cell body	Tyrosine-protein kinase Fyn	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosine-protein kinase Fyn	Homo sapiens (human)
perinuclear endoplasmic reticulum	Tyrosine-protein kinase Fyn	Homo sapiens (human)
glial cell projection	Tyrosine-protein kinase Fyn	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Tyrosine-protein kinase Fyn	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fyn	Homo sapiens (human)
mitochondrial matrix	Cyclin-dependent kinase 1	Homo sapiens (human)
chromosome, telomeric region	Cyclin-dependent kinase 1	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 1	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 1	Homo sapiens (human)
mitochondrion	Cyclin-dependent kinase 1	Homo sapiens (human)
endoplasmic reticulum membrane	Cyclin-dependent kinase 1	Homo sapiens (human)
centrosome	Cyclin-dependent kinase 1	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 1	Homo sapiens (human)
spindle microtubule	Cyclin-dependent kinase 1	Homo sapiens (human)
membrane	Cyclin-dependent kinase 1	Homo sapiens (human)
midbody	Cyclin-dependent kinase 1	Homo sapiens (human)
extracellular exosome	Cyclin-dependent kinase 1	Homo sapiens (human)
mitotic spindle	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin A1-CDK1 complex	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin A2-CDK1 complex	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin B1-CDK1 complex	Cyclin-dependent kinase 1	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 1	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 1	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 1	Homo sapiens (human)
extracellular region	Glycogen phosphorylase, liver form	Homo sapiens (human)
cytosol	Glycogen phosphorylase, liver form	Homo sapiens (human)
secretory granule lumen	Glycogen phosphorylase, liver form	Homo sapiens (human)
extracellular exosome	Glycogen phosphorylase, liver form	Homo sapiens (human)
ficolin-1-rich granule lumen	Glycogen phosphorylase, liver form	Homo sapiens (human)
cytoplasm	Glycogen phosphorylase, liver form	Homo sapiens (human)
cytoplasmic vesicle	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
Golgi apparatus	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
focal adhesion	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
cytoplasmic side of plasma membrane	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
microtubule cytoskeleton	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)
extracellular region	Adenine phosphoribosyltransferase	Homo sapiens (human)
nucleoplasm	Adenine phosphoribosyltransferase	Homo sapiens (human)
cytoplasm	Adenine phosphoribosyltransferase	Homo sapiens (human)
cytosol	Adenine phosphoribosyltransferase	Homo sapiens (human)
secretory granule lumen	Adenine phosphoribosyltransferase	Homo sapiens (human)
extracellular exosome	Adenine phosphoribosyltransferase	Homo sapiens (human)
cytoplasm	Adenine phosphoribosyltransferase	Homo sapiens (human)
Golgi apparatus	Tyrosine-protein kinase Yes	Homo sapiens (human)
centrosome	Tyrosine-protein kinase Yes	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Yes	Homo sapiens (human)
actin filament	Tyrosine-protein kinase Yes	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Yes	Homo sapiens (human)
focal adhesion	Tyrosine-protein kinase Yes	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase Yes	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Yes	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cytoplasmic side of plasma membrane	Tyrosine-protein kinase Lyn	Homo sapiens (human)
nucleus	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase Lyn	Homo sapiens (human)
lysosomal membrane	Tyrosine-protein kinase Lyn	Homo sapiens (human)
Golgi apparatus	Tyrosine-protein kinase Lyn	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Lyn	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Lyn	Homo sapiens (human)
adherens junction	Tyrosine-protein kinase Lyn	Homo sapiens (human)
mitochondrial crista	Tyrosine-protein kinase Lyn	Homo sapiens (human)
endocytic vesicle membrane	Tyrosine-protein kinase Lyn	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosine-protein kinase Lyn	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase Lyn	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosine-protein kinase Lyn	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase Lyn	Homo sapiens (human)
glutamatergic synapse	Tyrosine-protein kinase Lyn	Homo sapiens (human)
postsynaptic specialization, intracellular component	Tyrosine-protein kinase Lyn	Homo sapiens (human)
integrin alpha2-beta1 complex	Tyrosine-protein kinase Lyn	Homo sapiens (human)
plasma membrane	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
early endosome	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
plasma membrane	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
endosome membrane	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
dendrite	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
neuronal cell body	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
receptor complex	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
plasma membrane protein complex	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
axon	Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)
plasma membrane	Insulin-like growth factor 1 receptor	Homo sapiens (human)
caveola	Insulin-like growth factor 1 receptor	Homo sapiens (human)
membrane	Insulin-like growth factor 1 receptor	Homo sapiens (human)
T-tubule	Insulin-like growth factor 1 receptor	Homo sapiens (human)
neuronal cell body	Insulin-like growth factor 1 receptor	Homo sapiens (human)
intracellular membrane-bounded organelle	Insulin-like growth factor 1 receptor	Homo sapiens (human)
alphav-beta3 integrin-IGF-1-IGF1R complex	Insulin-like growth factor 1 receptor	Homo sapiens (human)
receptor complex	Insulin-like growth factor 1 receptor	Homo sapiens (human)
protein kinase complex	Insulin-like growth factor 1 receptor	Homo sapiens (human)
axon	Insulin-like growth factor 1 receptor	Homo sapiens (human)
plasma membrane	Insulin-like growth factor 1 receptor	Homo sapiens (human)
insulin receptor complex	Insulin-like growth factor 1 receptor	Homo sapiens (human)
signal recognition particle receptor complex	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
endoplasmic reticulum membrane	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
membrane	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
extracellular exosome	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
endoplasmic reticulum membrane	Signal recognition particle receptor subunit alpha	Homo sapiens (human)
nucleus	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
mitochondrion	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
mitochondrial respiratory chain complex III	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
membrane	Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)
extracellular region	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
cell surface	Hepatocyte growth factor receptor	Homo sapiens (human)
membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
postsynapse	Hepatocyte growth factor receptor	Homo sapiens (human)
basal plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
plasma membrane	Hepatocyte growth factor receptor	Homo sapiens (human)
receptor complex	Hepatocyte growth factor receptor	Homo sapiens (human)
actin filament	Tyrosine-protein kinase HCK	Homo sapiens (human)
nucleus	Tyrosine-protein kinase HCK	Homo sapiens (human)
lysosome	Tyrosine-protein kinase HCK	Homo sapiens (human)
Golgi apparatus	Tyrosine-protein kinase HCK	Homo sapiens (human)
cytosol	Tyrosine-protein kinase HCK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase HCK	Homo sapiens (human)
caveola	Tyrosine-protein kinase HCK	Homo sapiens (human)
focal adhesion	Tyrosine-protein kinase HCK	Homo sapiens (human)
cytoplasmic side of plasma membrane	Tyrosine-protein kinase HCK	Homo sapiens (human)
transport vesicle	Tyrosine-protein kinase HCK	Homo sapiens (human)
cell projection	Tyrosine-protein kinase HCK	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosine-protein kinase HCK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase HCK	Homo sapiens (human)
nucleus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasm	Platelet-derived growth factor receptor beta	Homo sapiens (human)
Golgi apparatus	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
focal adhesion	Platelet-derived growth factor receptor beta	Homo sapiens (human)
membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
apical plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
cytoplasmic vesicle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
lysosomal lumen	Platelet-derived growth factor receptor beta	Homo sapiens (human)
intracellular membrane-bounded organelle	Platelet-derived growth factor receptor beta	Homo sapiens (human)
plasma membrane	Platelet-derived growth factor receptor beta	Homo sapiens (human)
receptor complex	Platelet-derived growth factor receptor beta	Homo sapiens (human)
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cellular_component	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
mitochondrion	Serine/threonine-protein kinase A-Raf	Homo sapiens (human)
extracellular region	Glycogen phosphorylase, brain form	Homo sapiens (human)
cytoplasm	Glycogen phosphorylase, brain form	Homo sapiens (human)
membrane	Glycogen phosphorylase, brain form	Homo sapiens (human)
azurophil granule lumen	Glycogen phosphorylase, brain form	Homo sapiens (human)
extracellular exosome	Glycogen phosphorylase, brain form	Homo sapiens (human)
cytoplasm	Glycogen phosphorylase, brain form	Homo sapiens (human)
cytosol	Breakpoint cluster region protein	Homo sapiens (human)
plasma membrane	Breakpoint cluster region protein	Homo sapiens (human)
postsynaptic density	Breakpoint cluster region protein	Homo sapiens (human)
membrane	Breakpoint cluster region protein	Homo sapiens (human)
axon	Breakpoint cluster region protein	Homo sapiens (human)
dendritic spine	Breakpoint cluster region protein	Homo sapiens (human)
extracellular exosome	Breakpoint cluster region protein	Homo sapiens (human)
protein-containing complex	Breakpoint cluster region protein	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Breakpoint cluster region protein	Homo sapiens (human)
glutamatergic synapse	Breakpoint cluster region protein	Homo sapiens (human)
membrane	Breakpoint cluster region protein	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
nucleolus	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase pim-1	Homo sapiens (human)
extracellular region	Fibroblast growth factor receptor 1	Homo sapiens (human)
nucleus	Fibroblast growth factor receptor 1	Homo sapiens (human)
cytosol	Fibroblast growth factor receptor 1	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
cytoplasmic vesicle	Fibroblast growth factor receptor 1	Homo sapiens (human)
receptor complex	Fibroblast growth factor receptor 1	Homo sapiens (human)
plasma membrane	Fibroblast growth factor receptor 1	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nuclear chromosome	DNA topoisomerase 2-alpha	Homo sapiens (human)
centriole	DNA topoisomerase 2-alpha	Homo sapiens (human)
chromosome, centromeric region	DNA topoisomerase 2-alpha	Homo sapiens (human)
condensed chromosome	DNA topoisomerase 2-alpha	Homo sapiens (human)
male germ cell nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleoplasm	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-alpha	Homo sapiens (human)
cytoplasm	DNA topoisomerase 2-alpha	Homo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
protein-containing complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
ribonucleoprotein complex	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleus	DNA topoisomerase 2-alpha	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 4	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 4	Homo sapiens (human)
nucleolus	Cyclin-dependent kinase 4	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 4	Homo sapiens (human)
bicellular tight junction	Cyclin-dependent kinase 4	Homo sapiens (human)
nuclear membrane	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin D1-CDK4 complex	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin D2-CDK4 complex	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin D3-CDK4 complex	Cyclin-dependent kinase 4	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 4	Homo sapiens (human)
chromatin	Cyclin-dependent kinase 4	Homo sapiens (human)
transcription regulator complex	Cyclin-dependent kinase 4	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 4	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 4	Homo sapiens (human)
nucleus	ADP/ATP translocase 3	Homo sapiens (human)
mitochondrion	ADP/ATP translocase 3	Homo sapiens (human)
mitochondrial inner membrane	ADP/ATP translocase 3	Homo sapiens (human)
membrane	ADP/ATP translocase 3	Homo sapiens (human)
TIM23 mitochondrial import inner membrane translocase complex	ADP/ATP translocase 3	Homo sapiens (human)
extracellular region	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
nucleus	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
cytoplasm	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
peroxisomal membrane	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
cytosol	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
membrane	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
secretory granule lumen	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
extracellular exosome	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
ficolin-1-rich granule lumen	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
cytoplasm	Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)
podosome	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
nucleoplasm	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cytoplasm	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
mitochondrion	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
mitochondrial inner membrane	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
lysosome	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
late endosome	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cytosol	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
actin filament	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
plasma membrane	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
caveola	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
focal adhesion	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
cell junction	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
ruffle membrane	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
neuronal cell body	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
dendritic growth cone	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
membrane raft	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
perinuclear region of cytoplasm	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
extracellular exosome	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
synaptic membrane	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
glutamatergic synapse	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
postsynaptic specialization, intracellular component	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
dendritic filopodium	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
plasma membrane	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)
axoneme	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytoplasm	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
centrosome	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
plasma membrane	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
focal adhesion	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
membrane	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
plasma membrane raft	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
extracellular exosome	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
nucleotide-activated protein kinase complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
protein-containing complex	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
neuron projection	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
intracellular membrane-bounded organelle	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cell body	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
presynapse	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
mitochondrion	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase B-raf	Homo sapiens (human)
cytosol	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
phosphorylase kinase complex	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)
nucleoplasm	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
cytosol	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
extracellular exosome	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
cytosol	Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)
actin cytoskeleton	Tyrosine-protein kinase Fer	Homo sapiens (human)
microtubule cytoskeleton	Tyrosine-protein kinase Fer	Homo sapiens (human)
lamellipodium	Tyrosine-protein kinase Fer	Homo sapiens (human)
cell junction	Tyrosine-protein kinase Fer	Homo sapiens (human)
nucleus	Tyrosine-protein kinase Fer	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase Fer	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Fer	Homo sapiens (human)
adherens junction	Tyrosine-protein kinase Fer	Homo sapiens (human)
cell cortex	Tyrosine-protein kinase Fer	Homo sapiens (human)
cytoplasmic side of plasma membrane	Tyrosine-protein kinase Fer	Homo sapiens (human)
chromatin	Tyrosine-protein kinase Fer	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Fer	Homo sapiens (human)
ciliary basal body	Protein kinase C alpha type	Homo sapiens (human)
nucleoplasm	Protein kinase C alpha type	Homo sapiens (human)
cytoplasm	Protein kinase C alpha type	Homo sapiens (human)
mitochondrion	Protein kinase C alpha type	Homo sapiens (human)
endoplasmic reticulum	Protein kinase C alpha type	Homo sapiens (human)
cytosol	Protein kinase C alpha type	Homo sapiens (human)
plasma membrane	Protein kinase C alpha type	Homo sapiens (human)
mitochondrial membrane	Protein kinase C alpha type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C alpha type	Homo sapiens (human)
extracellular exosome	Protein kinase C alpha type	Homo sapiens (human)
alphav-beta3 integrin-PKCalpha complex	Protein kinase C alpha type	Homo sapiens (human)
axoneme	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cytoplasm	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
acrosomal vesicle	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
nucleus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
nucleoplasm	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cytoplasm	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
mitochondrial matrix	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
centrosome	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
plasma membrane	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
nuclear speck	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
neuromuscular junction	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
sperm flagellum	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
dendritic spine	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
plasma membrane raft	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
perinuclear region of cytoplasm	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
extracellular exosome	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
glutamatergic synapse	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
calcium channel complex	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
nucleus	cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)
nucleus	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
nucleoplasm	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
cytoplasm	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
spindle	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
cytosol	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription factor TFIIH core complex	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription factor TFIID complex	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
transcription factor TFIIH holo complex	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
CAK-ERCC2 complex	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
MMXD complex	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
nucleus	General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)
PcG protein complex	Casein kinase II subunit alpha'	Homo sapiens (human)
acrosomal vesicle	Casein kinase II subunit alpha'	Homo sapiens (human)
nucleus	Casein kinase II subunit alpha'	Homo sapiens (human)
nucleoplasm	Casein kinase II subunit alpha'	Homo sapiens (human)
cytosol	Casein kinase II subunit alpha'	Homo sapiens (human)
protein kinase CK2 complex	Casein kinase II subunit alpha'	Homo sapiens (human)
chromatin	Casein kinase II subunit alpha'	Homo sapiens (human)
cytosol	Casein kinase II subunit alpha'	Homo sapiens (human)
nucleus	Casein kinase II subunit alpha'	Homo sapiens (human)
Golgi membrane	Ras-related protein Rab-6A	Homo sapiens (human)
acrosomal membrane	Ras-related protein Rab-6A	Homo sapiens (human)
endoplasmic reticulum membrane	Ras-related protein Rab-6A	Homo sapiens (human)
Golgi apparatus	Ras-related protein Rab-6A	Homo sapiens (human)
trans-Golgi network	Ras-related protein Rab-6A	Homo sapiens (human)
cytosol	Ras-related protein Rab-6A	Homo sapiens (human)
plasma membrane	Ras-related protein Rab-6A	Homo sapiens (human)
membrane	Ras-related protein Rab-6A	Homo sapiens (human)
secretory granule membrane	Ras-related protein Rab-6A	Homo sapiens (human)
cytoplasmic vesicle	Ras-related protein Rab-6A	Homo sapiens (human)
trans-Golgi network membrane	Ras-related protein Rab-6A	Homo sapiens (human)
extracellular exosome	Ras-related protein Rab-6A	Homo sapiens (human)
endosome to plasma membrane transport vesicle	Ras-related protein Rab-6A	Homo sapiens (human)
Golgi apparatus	Ras-related protein Rab-6A	Homo sapiens (human)
endomembrane system	Ras-related protein Rab-6A	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 1	Homo sapiens (human)
receptor complex	Ephrin type-A receptor 1	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 1	Homo sapiens (human)
extracellular space	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
basolateral plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
apical plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
lateral plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
ERBB3:ERBB2 complex	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
receptor complex	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
basal plasma membrane	Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)
cytoplasm	Multifunctional protein ADE2	Homo sapiens (human)
cytosol	Multifunctional protein ADE2	Homo sapiens (human)
membrane	Multifunctional protein ADE2	Homo sapiens (human)
extracellular exosome	Multifunctional protein ADE2	Homo sapiens (human)
focal adhesion	Nucleoside diphosphate kinase B	Homo sapiens (human)
ruffle	Nucleoside diphosphate kinase B	Homo sapiens (human)
extracellular region	Nucleoside diphosphate kinase B	Homo sapiens (human)
nucleus	Nucleoside diphosphate kinase B	Homo sapiens (human)
cytoplasm	Nucleoside diphosphate kinase B	Homo sapiens (human)
cytosol	Nucleoside diphosphate kinase B	Homo sapiens (human)
lamellipodium	Nucleoside diphosphate kinase B	Homo sapiens (human)
secretory granule lumen	Nucleoside diphosphate kinase B	Homo sapiens (human)
perinuclear region of cytoplasm	Nucleoside diphosphate kinase B	Homo sapiens (human)
extracellular exosome	Nucleoside diphosphate kinase B	Homo sapiens (human)
cell periphery	Nucleoside diphosphate kinase B	Homo sapiens (human)
ficolin-1-rich granule lumen	Nucleoside diphosphate kinase B	Homo sapiens (human)
nucleoplasm	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
nucleus	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)
nucleoplasm	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
centrosome	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
plasma membrane	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
extracellular exosome	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
ciliary base	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
cAMP-dependent protein kinase complex	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
cytosol	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
nucleus	cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)
mitochondrial inner membrane	Ferrochelatase, mitochondrial	Homo sapiens (human)
mitochondrial matrix	Ferrochelatase, mitochondrial	Homo sapiens (human)
mitochondrion	Ferrochelatase, mitochondrial	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
mitochondrion	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
mitochondrial outer membrane	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cytosol	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cell surface	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
neuron projection	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
perinuclear region of cytoplasm	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
postsynapse	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
glutamatergic synapse	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase beta-1	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase JAK1	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytoplasmic side of plasma membrane	Tyrosine-protein kinase JAK1	Homo sapiens (human)
extrinsic component of cytoplasmic side of plasma membrane	Tyrosine-protein kinase JAK1	Homo sapiens (human)
nucleus	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase JAK1	Homo sapiens (human)
endosome	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytosol	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytoskeleton	Tyrosine-protein kinase JAK1	Homo sapiens (human)
focal adhesion	Tyrosine-protein kinase JAK1	Homo sapiens (human)
cytosol	Tyrosine-protein kinase JAK1	Homo sapiens (human)
chromosome, telomeric region	Cyclin-dependent kinase 2	Homo sapiens (human)
condensed chromosome	Cyclin-dependent kinase 2	Homo sapiens (human)
X chromosome	Cyclin-dependent kinase 2	Homo sapiens (human)
Y chromosome	Cyclin-dependent kinase 2	Homo sapiens (human)
male germ cell nucleus	Cyclin-dependent kinase 2	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 2	Homo sapiens (human)
nuclear envelope	Cyclin-dependent kinase 2	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 2	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 2	Homo sapiens (human)
endosome	Cyclin-dependent kinase 2	Homo sapiens (human)
centrosome	Cyclin-dependent kinase 2	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 2	Homo sapiens (human)
Cajal body	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin A1-CDK2 complex	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin A2-CDK2 complex	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin E1-CDK2 complex	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin E2-CDK2 complex	Cyclin-dependent kinase 2	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 2	Homo sapiens (human)
transcription regulator complex	Cyclin-dependent kinase 2	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 2	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 2	Homo sapiens (human)
cytoplasm	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
cytosol	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
plasma membrane	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
cilium	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
membrane	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
presynapse	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
postsynapse	Beta-adrenergic receptor kinase 1	Homo sapiens (human)
P-body	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
nucleus	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cytoplasm	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cytosol	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cytoplasmic stress granule	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
membrane	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
RISC complex	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
cytoplasmic stress granule	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
P-body	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 3	Homo sapiens (human)
nuclear envelope	Mitogen-activated protein kinase 3	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 3	Homo sapiens (human)
early endosome	Mitogen-activated protein kinase 3	Homo sapiens (human)
late endosome	Mitogen-activated protein kinase 3	Homo sapiens (human)
endoplasmic reticulum lumen	Mitogen-activated protein kinase 3	Homo sapiens (human)
Golgi apparatus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoskeleton	Mitogen-activated protein kinase 3	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase 3	Homo sapiens (human)
caveola	Mitogen-activated protein kinase 3	Homo sapiens (human)
focal adhesion	Mitogen-activated protein kinase 3	Homo sapiens (human)
pseudopodium	Mitogen-activated protein kinase 3	Homo sapiens (human)
glutamatergic synapse	Mitogen-activated protein kinase 3	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 3	Homo sapiens (human)
cytoplasm	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
cytosol	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
plasma membrane	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
dendrite	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
extracellular exosome	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
plasma membrane	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
cytoplasm	MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)
nucleoplasm	Deoxycytidine kinase	Homo sapiens (human)
cytosol	Deoxycytidine kinase	Homo sapiens (human)
mitochondrion	Deoxycytidine kinase	Homo sapiens (human)
cytoplasm	Deoxycytidine kinase	Homo sapiens (human)
extracellular region	Mitogen-activated protein kinase 1	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 1	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 1	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 1	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 1	Homo sapiens (human)
early endosome	Mitogen-activated protein kinase 1	Homo sapiens (human)
late endosome	Mitogen-activated protein kinase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Mitogen-activated protein kinase 1	Homo sapiens (human)
Golgi apparatus	Mitogen-activated protein kinase 1	Homo sapiens (human)
centrosome	Mitogen-activated protein kinase 1	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 1	Homo sapiens (human)
cytoskeleton	Mitogen-activated protein kinase 1	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase 1	Homo sapiens (human)
caveola	Mitogen-activated protein kinase 1	Homo sapiens (human)
focal adhesion	Mitogen-activated protein kinase 1	Homo sapiens (human)
pseudopodium	Mitogen-activated protein kinase 1	Homo sapiens (human)
azurophil granule lumen	Mitogen-activated protein kinase 1	Homo sapiens (human)
synapse	Mitogen-activated protein kinase 1	Homo sapiens (human)
mitotic spindle	Mitogen-activated protein kinase 1	Homo sapiens (human)
ficolin-1-rich granule lumen	Mitogen-activated protein kinase 1	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 1	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 1	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 2	Homo sapiens (human)
focal adhesion	Ephrin type-A receptor 2	Homo sapiens (human)
cell surface	Ephrin type-A receptor 2	Homo sapiens (human)
lamellipodium	Ephrin type-A receptor 2	Homo sapiens (human)
leading edge membrane	Ephrin type-A receptor 2	Homo sapiens (human)
lamellipodium membrane	Ephrin type-A receptor 2	Homo sapiens (human)
ruffle membrane	Ephrin type-A receptor 2	Homo sapiens (human)
tight junction	Ephrin type-A receptor 2	Homo sapiens (human)
receptor complex	Ephrin type-A receptor 2	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 2	Homo sapiens (human)
extracellular region	Ephrin type-B receptor 2	Homo sapiens (human)
nucleoplasm	Ephrin type-B receptor 2	Homo sapiens (human)
cytosol	Ephrin type-B receptor 2	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 2	Homo sapiens (human)
cell surface	Ephrin type-B receptor 2	Homo sapiens (human)
axon	Ephrin type-B receptor 2	Homo sapiens (human)
dendrite	Ephrin type-B receptor 2	Homo sapiens (human)
presynaptic membrane	Ephrin type-B receptor 2	Homo sapiens (human)
neuronal cell body	Ephrin type-B receptor 2	Homo sapiens (human)
dendritic spine	Ephrin type-B receptor 2	Homo sapiens (human)
postsynaptic membrane	Ephrin type-B receptor 2	Homo sapiens (human)
hippocampal mossy fiber to CA3 synapse	Ephrin type-B receptor 2	Homo sapiens (human)
postsynapse	Ephrin type-B receptor 2	Homo sapiens (human)
glutamatergic synapse	Ephrin type-B receptor 2	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 2	Homo sapiens (human)
dendrite	Ephrin type-B receptor 2	Homo sapiens (human)
plasma membrane	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytoplasmic side of plasma membrane	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
extrinsic component of plasma membrane	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
extrinsic component of cytoplasmic side of plasma membrane	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
nucleus	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytoplasm	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytosol	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytoskeleton	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
plasma membrane	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
interleukin-12 receptor complex	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
extracellular exosome	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
interleukin-23 receptor complex	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
cytosol	Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)
nucleoplasm	UMP-CMP kinase	Homo sapiens (human)
nucleolus	UMP-CMP kinase	Homo sapiens (human)
cytosol	UMP-CMP kinase	Homo sapiens (human)
extracellular exosome	UMP-CMP kinase	Homo sapiens (human)
cytoplasm	UMP-CMP kinase	Homo sapiens (human)
nucleus	UMP-CMP kinase	Homo sapiens (human)
nucleus	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
cytosol	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
extracellular exosome	Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)
nucleus	Wee1-like protein kinase	Homo sapiens (human)
nucleoplasm	Wee1-like protein kinase	Homo sapiens (human)
nucleolus	Wee1-like protein kinase	Homo sapiens (human)
cytoplasm	Wee1-like protein kinase	Homo sapiens (human)
endoplasmic reticulum membrane	Heme oxygenase 2	Homo sapiens (human)
plasma membrane	Heme oxygenase 2	Homo sapiens (human)
membrane	Heme oxygenase 2	Homo sapiens (human)
specific granule membrane	Heme oxygenase 2	Homo sapiens (human)
cytosol	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
methionine adenosyltransferase complex	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
cytosol	S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)
nucleus	DnaJ homolog subfamily A member 1	Homo sapiens (human)
mitochondrion	DnaJ homolog subfamily A member 1	Homo sapiens (human)
cytosol	DnaJ homolog subfamily A member 1	Homo sapiens (human)
microtubule cytoskeleton	DnaJ homolog subfamily A member 1	Homo sapiens (human)
membrane	DnaJ homolog subfamily A member 1	Homo sapiens (human)
perinuclear region of cytoplasm	DnaJ homolog subfamily A member 1	Homo sapiens (human)
extracellular exosome	DnaJ homolog subfamily A member 1	Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membrane	DnaJ homolog subfamily A member 1	Homo sapiens (human)
cytoplasm	DnaJ homolog subfamily A member 1	Homo sapiens (human)
cytosol	DnaJ homolog subfamily A member 1	Homo sapiens (human)
cytoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
mitochondrial intermembrane space	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleus	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytoplasm	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
spindle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cytosol	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
plasma membrane	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell-cell junction	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
cell cortex	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
microtubule cytoskeleton	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
lamellipodium	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
vesicle	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
ciliary basal body	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
postsynapse	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
glutamatergic synapse	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
protein-containing complex	RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)
nucleus	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
nucleoplasm	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
early endosome	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cytosol	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
plasma membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
cell cortex	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
ruffle membrane	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
intracellular membrane-bounded organelle	RAC-beta serine/threonine-protein kinase	Homo sapiens (human)
chromosome, telomeric region	DNA replication licensing factor MCM4	Homo sapiens (human)
nucleus	DNA replication licensing factor MCM4	Homo sapiens (human)
nucleoplasm	DNA replication licensing factor MCM4	Homo sapiens (human)
membrane	DNA replication licensing factor MCM4	Homo sapiens (human)
MCM complex	DNA replication licensing factor MCM4	Homo sapiens (human)
CMG complex	DNA replication licensing factor MCM4	Homo sapiens (human)
nucleus	DNA replication licensing factor MCM4	Homo sapiens (human)
postsynaptic actin cytoskeleton	Myosin-10	Homo sapiens (human)
stress fiber	Myosin-10	Homo sapiens (human)
nucleus	Myosin-10	Homo sapiens (human)
cytoplasm	Myosin-10	Homo sapiens (human)
cytosol	Myosin-10	Homo sapiens (human)
cell cortex	Myosin-10	Homo sapiens (human)
lamellipodium	Myosin-10	Homo sapiens (human)
midbody	Myosin-10	Homo sapiens (human)
cleavage furrow	Myosin-10	Homo sapiens (human)
actomyosin	Myosin-10	Homo sapiens (human)
extracellular exosome	Myosin-10	Homo sapiens (human)
myosin II filament	Myosin-10	Homo sapiens (human)
myosin complex	Myosin-10	Homo sapiens (human)
myosin II complex	Myosin-10	Homo sapiens (human)
myosin filament	Myosin-10	Homo sapiens (human)
cytoplasm	Myosin-10	Homo sapiens (human)
extracellular region	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
nucleus	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
mitochondrion	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
early endosome	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
late endosome	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
peroxisomal membrane	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
endoplasmic reticulum	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
Golgi apparatus	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
microtubule	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
cell-cell junction	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
focal adhesion	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
cytoplasmic side of plasma membrane	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
perinuclear region of cytoplasm	Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)
endoplasmic reticulum	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
endoplasmic reticulum lumen	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
plasma membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
endosome membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
receptor complex	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
plasma membrane	Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)
caveola	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
plasma membrane	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
external side of plasma membrane	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
membrane	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
dendrite	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
neuronal cell body	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
HFE-transferrin receptor complex	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
plasma membrane	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
receptor complex	Bone morphogenetic protein receptor type-1A	Homo sapiens (human)
cytosol	Activin receptor type-1B	Homo sapiens (human)
plasma membrane	Activin receptor type-1B	Homo sapiens (human)
cell surface	Activin receptor type-1B	Homo sapiens (human)
receptor complex	Activin receptor type-1B	Homo sapiens (human)
activin receptor complex	Activin receptor type-1B	Homo sapiens (human)
plasma membrane	Activin receptor type-1B	Homo sapiens (human)
nucleus	TGF-beta receptor type-1	Homo sapiens (human)
endosome	TGF-beta receptor type-1	Homo sapiens (human)
plasma membrane	TGF-beta receptor type-1	Homo sapiens (human)
bicellular tight junction	TGF-beta receptor type-1	Homo sapiens (human)
cell surface	TGF-beta receptor type-1	Homo sapiens (human)
membrane raft	TGF-beta receptor type-1	Homo sapiens (human)
transforming growth factor beta ligand-receptor complex	TGF-beta receptor type-1	Homo sapiens (human)
receptor complex	TGF-beta receptor type-1	Homo sapiens (human)
plasma membrane	TGF-beta receptor type-1	Homo sapiens (human)
activin receptor complex	TGF-beta receptor type-1	Homo sapiens (human)
mitochondrion	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
mitochondrial matrix	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
electron transfer flavoprotein complex	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
mitochondrion	Electron transfer flavoprotein subunit beta	Homo sapiens (human)
endoplasmic reticulum	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
intracellular non-membrane-bounded organelle	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
nucleus	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
nucleoplasm	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
mitochondrion	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
endoplasmic reticulum	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
cytosol	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
plasma membrane	von Hippel-Lindau disease tumor suppressor	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase CSK	Homo sapiens (human)
cytosol	Tyrosine-protein kinase CSK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase CSK	Homo sapiens (human)
cell-cell junction	Tyrosine-protein kinase CSK	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase CSK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase CSK	Homo sapiens (human)
mitochondrial matrix	Glycine--tRNA ligase	Homo sapiens (human)
cytosol	Glycine--tRNA ligase	Homo sapiens (human)
secretory granule	Glycine--tRNA ligase	Homo sapiens (human)
axon	Glycine--tRNA ligase	Homo sapiens (human)
extracellular exosome	Glycine--tRNA ligase	Homo sapiens (human)
cytoplasm	Glycine--tRNA ligase	Homo sapiens (human)
mitochondrion	Glycine--tRNA ligase	Homo sapiens (human)
Golgi membrane	Protein kinase C iota type	Homo sapiens (human)
nucleus	Protein kinase C iota type	Homo sapiens (human)
nucleoplasm	Protein kinase C iota type	Homo sapiens (human)
endosome	Protein kinase C iota type	Homo sapiens (human)
cytosol	Protein kinase C iota type	Homo sapiens (human)
plasma membrane	Protein kinase C iota type	Homo sapiens (human)
brush border	Protein kinase C iota type	Homo sapiens (human)
bicellular tight junction	Protein kinase C iota type	Homo sapiens (human)
microtubule cytoskeleton	Protein kinase C iota type	Homo sapiens (human)
apical plasma membrane	Protein kinase C iota type	Homo sapiens (human)
cell leading edge	Protein kinase C iota type	Homo sapiens (human)
Schmidt-Lanterman incisure	Protein kinase C iota type	Homo sapiens (human)
intercellular bridge	Protein kinase C iota type	Homo sapiens (human)
extracellular exosome	Protein kinase C iota type	Homo sapiens (human)
tight junction	Protein kinase C iota type	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Protein kinase C iota type	Homo sapiens (human)
glutamatergic synapse	Protein kinase C iota type	Homo sapiens (human)
PAR polarity complex	Protein kinase C iota type	Homo sapiens (human)
nuclear exosome (RNase complex)	Exosome RNA helicase MTR4	Homo sapiens (human)
exosome (RNase complex)	Exosome RNA helicase MTR4	Homo sapiens (human)
nucleus	Exosome RNA helicase MTR4	Homo sapiens (human)
nucleoplasm	Exosome RNA helicase MTR4	Homo sapiens (human)
nucleolus	Exosome RNA helicase MTR4	Homo sapiens (human)
nuclear speck	Exosome RNA helicase MTR4	Homo sapiens (human)
TRAMP complex	Exosome RNA helicase MTR4	Homo sapiens (human)
catalytic step 2 spliceosome	Exosome RNA helicase MTR4	Homo sapiens (human)
nucleus	Exosome RNA helicase MTR4	Homo sapiens (human)
cytosol	Tyrosine-protein kinase Tec	Homo sapiens (human)
cytoskeleton	Tyrosine-protein kinase Tec	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Tec	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase Tec	Homo sapiens (human)
cytosol	Tyrosine-protein kinase ABL2	Homo sapiens (human)
actin cytoskeleton	Tyrosine-protein kinase ABL2	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase ABL2	Homo sapiens (human)
extracellular region	Tyrosine-protein kinase FRK	Homo sapiens (human)
nucleus	Tyrosine-protein kinase FRK	Homo sapiens (human)
nucleoplasm	Tyrosine-protein kinase FRK	Homo sapiens (human)
cytosol	Tyrosine-protein kinase FRK	Homo sapiens (human)
azurophil granule lumen	Tyrosine-protein kinase FRK	Homo sapiens (human)
specific granule lumen	Tyrosine-protein kinase FRK	Homo sapiens (human)
extracellular exosome	Tyrosine-protein kinase FRK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase FRK	Homo sapiens (human)
plasma membrane	G protein-coupled receptor kinase 6	Homo sapiens (human)
membrane	G protein-coupled receptor kinase 6	Homo sapiens (human)
cytoplasm	G protein-coupled receptor kinase 6	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase SYK	Homo sapiens (human)
nucleus	Tyrosine-protein kinase SYK	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase SYK	Homo sapiens (human)
cytosol	Tyrosine-protein kinase SYK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase SYK	Homo sapiens (human)
early phagosome	Tyrosine-protein kinase SYK	Homo sapiens (human)
B cell receptor complex	Tyrosine-protein kinase SYK	Homo sapiens (human)
protein-containing complex	Tyrosine-protein kinase SYK	Homo sapiens (human)
T cell receptor complex	Tyrosine-protein kinase SYK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase SYK	Homo sapiens (human)
proteasome complex	26S proteasome regulatory subunit 6B	Homo sapiens (human)
nucleus	26S proteasome regulatory subunit 6B	Homo sapiens (human)
nucleoplasm	26S proteasome regulatory subunit 6B	Homo sapiens (human)
cytosol	26S proteasome regulatory subunit 6B	Homo sapiens (human)
membrane	26S proteasome regulatory subunit 6B	Homo sapiens (human)
inclusion body	26S proteasome regulatory subunit 6B	Homo sapiens (human)
synapse	26S proteasome regulatory subunit 6B	Homo sapiens (human)
proteasome accessory complex	26S proteasome regulatory subunit 6B	Homo sapiens (human)
cytosolic proteasome complex	26S proteasome regulatory subunit 6B	Homo sapiens (human)
proteasome regulatory particle, base subcomplex	26S proteasome regulatory subunit 6B	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 8	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 8	Homo sapiens (human)
axon	Mitogen-activated protein kinase 8	Homo sapiens (human)
synapse	Mitogen-activated protein kinase 8	Homo sapiens (human)
basal dendrite	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 8	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 9	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 9	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 9	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase 9	Homo sapiens (human)
nuclear speck	Mitogen-activated protein kinase 9	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Mitogen-activated protein kinase 9	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 9	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 9	Homo sapiens (human)
cytoplasm	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
nucleoplasm	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
membrane	Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)
photoreceptor outer segment	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
photoreceptor inner segment	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
nucleoplasm	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
lysosome	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
autophagosome	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
cytosol	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)
mRNA cleavage and polyadenylation specificity factor complex	Casein kinase I isoform alpha	Homo sapiens (human)
keratin filament	Casein kinase I isoform alpha	Homo sapiens (human)
kinetochore	Casein kinase I isoform alpha	Homo sapiens (human)
centrosome	Casein kinase I isoform alpha	Homo sapiens (human)
spindle	Casein kinase I isoform alpha	Homo sapiens (human)
cytosol	Casein kinase I isoform alpha	Homo sapiens (human)
cilium	Casein kinase I isoform alpha	Homo sapiens (human)
membrane	Casein kinase I isoform alpha	Homo sapiens (human)
nuclear speck	Casein kinase I isoform alpha	Homo sapiens (human)
beta-catenin destruction complex	Casein kinase I isoform alpha	Homo sapiens (human)
ciliary basal body	Casein kinase I isoform alpha	Homo sapiens (human)
cytoplasm	Casein kinase I isoform alpha	Homo sapiens (human)
nucleus	Casein kinase I isoform alpha	Homo sapiens (human)
nucleus	Casein kinase I isoform delta	Homo sapiens (human)
nucleoplasm	Casein kinase I isoform delta	Homo sapiens (human)
Golgi apparatus	Casein kinase I isoform delta	Homo sapiens (human)
centrosome	Casein kinase I isoform delta	Homo sapiens (human)
spindle	Casein kinase I isoform delta	Homo sapiens (human)
cytosol	Casein kinase I isoform delta	Homo sapiens (human)
spindle microtubule	Casein kinase I isoform delta	Homo sapiens (human)
plasma membrane	Casein kinase I isoform delta	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Casein kinase I isoform delta	Homo sapiens (human)
ciliary basal body	Casein kinase I isoform delta	Homo sapiens (human)
perinuclear region of cytoplasm	Casein kinase I isoform delta	Homo sapiens (human)
nucleus	Casein kinase I isoform delta	Homo sapiens (human)
cytoplasm	Casein kinase I isoform delta	Homo sapiens (human)
spindle microtubule	Casein kinase I isoform delta	Homo sapiens (human)
nucleus	MAP kinase-activated protein kinase 2	Homo sapiens (human)
nucleoplasm	MAP kinase-activated protein kinase 2	Homo sapiens (human)
cytoplasm	MAP kinase-activated protein kinase 2	Homo sapiens (human)
centrosome	MAP kinase-activated protein kinase 2	Homo sapiens (human)
cytosol	MAP kinase-activated protein kinase 2	Homo sapiens (human)
extracellular exosome	MAP kinase-activated protein kinase 2	Homo sapiens (human)
nucleus	MAP kinase-activated protein kinase 2	Homo sapiens (human)
cytoplasm	MAP kinase-activated protein kinase 2	Homo sapiens (human)
mitochondrion	Elongation factor Tu, mitochondrial	Homo sapiens (human)
mitochondrial outer membrane	Elongation factor Tu, mitochondrial	Homo sapiens (human)
membrane	Elongation factor Tu, mitochondrial	Homo sapiens (human)
mitochondrial nucleoid	Elongation factor Tu, mitochondrial	Homo sapiens (human)
synapse	Elongation factor Tu, mitochondrial	Homo sapiens (human)
extracellular exosome	Elongation factor Tu, mitochondrial	Homo sapiens (human)
mitochondrion	Elongation factor Tu, mitochondrial	Homo sapiens (human)
cytoplasm	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cytosol	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cytoplasm	Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)
nucleus	Casein kinase I isoform epsilon	Homo sapiens (human)
nucleoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
cytoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
cytosol	Casein kinase I isoform epsilon	Homo sapiens (human)
growth cone	Casein kinase I isoform epsilon	Homo sapiens (human)
neuronal cell body	Casein kinase I isoform epsilon	Homo sapiens (human)
ribonucleoprotein complex	Casein kinase I isoform epsilon	Homo sapiens (human)
cytoplasm	Casein kinase I isoform epsilon	Homo sapiens (human)
nucleus	Casein kinase I isoform epsilon	Homo sapiens (human)
nucleoplasm	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
nucleolus	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrion	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrial inner membrane	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrial matrix	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrial membrane	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
mitochondrial nucleoid	Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)
nucleus	Dual specificity protein kinase CLK1	Homo sapiens (human)
nucleus	Dual specificity protein kinase CLK2	Homo sapiens (human)
nucleoplasm	Dual specificity protein kinase CLK2	Homo sapiens (human)
nuclear body	Dual specificity protein kinase CLK2	Homo sapiens (human)
nuclear speck	Dual specificity protein kinase CLK2	Homo sapiens (human)
nucleus	Dual specificity protein kinase CLK2	Homo sapiens (human)
acrosomal vesicle	Dual specificity protein kinase CLK3	Homo sapiens (human)
nucleus	Dual specificity protein kinase CLK3	Homo sapiens (human)
nucleoplasm	Dual specificity protein kinase CLK3	Homo sapiens (human)
membrane	Dual specificity protein kinase CLK3	Homo sapiens (human)
nuclear speck	Dual specificity protein kinase CLK3	Homo sapiens (human)
intermediate filament cytoskeleton	Dual specificity protein kinase CLK3	Homo sapiens (human)
mitochondrion	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cytosol	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
beta-catenin destruction complex	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
neuronal cell body	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
apical dendrite	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
postsynapse	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
proximal dendrite	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cytoplasm	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
nucleus	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
axon	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
cytosol	Glycogen synthase kinase-3 alpha	Homo sapiens (human)
glutamatergic synapse	Glycogen synthase kinase-3 beta	Homo sapiens (human)
nucleus	Glycogen synthase kinase-3 beta	Homo sapiens (human)
nucleoplasm	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cytoplasm	Glycogen synthase kinase-3 beta	Homo sapiens (human)
mitochondrion	Glycogen synthase kinase-3 beta	Homo sapiens (human)
centrosome	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cytosol	Glycogen synthase kinase-3 beta	Homo sapiens (human)
plasma membrane	Glycogen synthase kinase-3 beta	Homo sapiens (human)
axon	Glycogen synthase kinase-3 beta	Homo sapiens (human)
dendrite	Glycogen synthase kinase-3 beta	Homo sapiens (human)
beta-catenin destruction complex	Glycogen synthase kinase-3 beta	Homo sapiens (human)
presynapse	Glycogen synthase kinase-3 beta	Homo sapiens (human)
postsynapse	Glycogen synthase kinase-3 beta	Homo sapiens (human)
Wnt signalosome	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cytosol	Glycogen synthase kinase-3 beta	Homo sapiens (human)
axon	Glycogen synthase kinase-3 beta	Homo sapiens (human)
nucleus	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cytoplasm	Glycogen synthase kinase-3 beta	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 7	Homo sapiens (human)
fibrillar center	Cyclin-dependent kinase 7	Homo sapiens (human)
male germ cell nucleus	Cyclin-dependent kinase 7	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 7	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 7	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 7	Homo sapiens (human)
plasma membrane	Cyclin-dependent kinase 7	Homo sapiens (human)
perinuclear region of cytoplasm	Cyclin-dependent kinase 7	Homo sapiens (human)
transcription factor TFIIH core complex	Cyclin-dependent kinase 7	Homo sapiens (human)
transcription factor TFIIH holo complex	Cyclin-dependent kinase 7	Homo sapiens (human)
CAK-ERCC2 complex	Cyclin-dependent kinase 7	Homo sapiens (human)
transcription factor TFIIK complex	Cyclin-dependent kinase 7	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 7	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 7	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 9	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 9	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 9	Homo sapiens (human)
cyclin/CDK positive transcription elongation factor complex	Cyclin-dependent kinase 9	Homo sapiens (human)
membrane	Cyclin-dependent kinase 9	Homo sapiens (human)
PML body	Cyclin-dependent kinase 9	Homo sapiens (human)
cytoplasmic ribonucleoprotein granule	Cyclin-dependent kinase 9	Homo sapiens (human)
transcription elongation factor complex	Cyclin-dependent kinase 9	Homo sapiens (human)
P-TEFb complex	Cyclin-dependent kinase 9	Homo sapiens (human)
photoreceptor outer segment	Ras-related protein Rab-27A	Homo sapiens (human)
extracellular region	Ras-related protein Rab-27A	Homo sapiens (human)
lysosome	Ras-related protein Rab-27A	Homo sapiens (human)
late endosome	Ras-related protein Rab-27A	Homo sapiens (human)
cytosol	Ras-related protein Rab-27A	Homo sapiens (human)
dendrite	Ras-related protein Rab-27A	Homo sapiens (human)
multivesicular body membrane	Ras-related protein Rab-27A	Homo sapiens (human)
Weibel-Palade body	Ras-related protein Rab-27A	Homo sapiens (human)
melanosome membrane	Ras-related protein Rab-27A	Homo sapiens (human)
specific granule lumen	Ras-related protein Rab-27A	Homo sapiens (human)
melanosome	Ras-related protein Rab-27A	Homo sapiens (human)
extracellular exosome	Ras-related protein Rab-27A	Homo sapiens (human)
exocytic vesicle	Ras-related protein Rab-27A	Homo sapiens (human)
exocytic vesicle	Ras-related protein Rab-27A	Homo sapiens (human)
apical plasma membrane	Ras-related protein Rab-27A	Homo sapiens (human)
Golgi apparatus	Ras-related protein Rab-27A	Homo sapiens (human)
secretory granule	Ras-related protein Rab-27A	Homo sapiens (human)
melanosome	Ras-related protein Rab-27A	Homo sapiens (human)
cytoplasm	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
cell surface	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
nucleoplasm	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
lipid droplet	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
cytosol	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
plasma membrane	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
endosome membrane	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
protein-containing complex	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
nucleus	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
plasma membrane	Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
nucleolus	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
cytosol	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
synapse	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)
kinetochore	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
kinetochore	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
condensed nuclear chromosome	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
spindle pole	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
nucleolus	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
microtubule	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
midbody	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Nek2	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
axon	Serine/threonine-protein kinase Nek3	Homo sapiens (human)
cytoplasm	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
nucleoplasm	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
cytoskeleton	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)
extracellular region	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular space	Dipeptidyl peptidase 1	Homo sapiens (human)
nucleoplasm	Dipeptidyl peptidase 1	Homo sapiens (human)
lysosome	Dipeptidyl peptidase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Dipeptidyl peptidase 1	Homo sapiens (human)
centrosome	Dipeptidyl peptidase 1	Homo sapiens (human)
membrane	Dipeptidyl peptidase 1	Homo sapiens (human)
COPII-coated ER to Golgi transport vesicle	Dipeptidyl peptidase 1	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Dipeptidyl peptidase 1	Homo sapiens (human)
azurophil granule lumen	Dipeptidyl peptidase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Dipeptidyl peptidase 1	Homo sapiens (human)
collagen-containing extracellular matrix	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular exosome	Dipeptidyl peptidase 1	Homo sapiens (human)
lysosome	Dipeptidyl peptidase 1	Homo sapiens (human)
extracellular space	Dipeptidyl peptidase 1	Homo sapiens (human)
postsynapse	LIM domain kinase 1	Homo sapiens (human)
glutamatergic synapse	LIM domain kinase 1	Homo sapiens (human)
male germ cell nucleus	LIM domain kinase 1	Homo sapiens (human)
cytoplasm	LIM domain kinase 1	Homo sapiens (human)
cytosol	LIM domain kinase 1	Homo sapiens (human)
cytoskeleton	LIM domain kinase 1	Homo sapiens (human)
focal adhesion	LIM domain kinase 1	Homo sapiens (human)
membrane	LIM domain kinase 1	Homo sapiens (human)
nuclear speck	LIM domain kinase 1	Homo sapiens (human)
lamellipodium	LIM domain kinase 1	Homo sapiens (human)
neuron projection	LIM domain kinase 1	Homo sapiens (human)
nucleus	LIM domain kinase 1	Homo sapiens (human)
neuron projection	LIM domain kinase 1	Homo sapiens (human)
cytoplasm	LIM domain kinase 1	Homo sapiens (human)
nucleus	LIM domain kinase 2	Homo sapiens (human)
cytoplasm	LIM domain kinase 2	Homo sapiens (human)
cis-Golgi network	LIM domain kinase 2	Homo sapiens (human)
centrosome	LIM domain kinase 2	Homo sapiens (human)
perinuclear region of cytoplasm	LIM domain kinase 2	Homo sapiens (human)
mitotic spindle	LIM domain kinase 2	Homo sapiens (human)
nucleus	LIM domain kinase 2	Homo sapiens (human)
cytoplasm	LIM domain kinase 2	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 10	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 10	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 10	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 10	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase 10	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 10	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 10	Homo sapiens (human)
nucleus	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cytoplasm	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cytosol	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
extracellular space	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
cytosol	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
nuclear body	Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)
nucleus	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
nucleoplasm	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
cytosol	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
membrane	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
nucleotide-activated protein kinase complex	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
nucleus	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
cytoplasm	5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)
extracellular region	Ephrin type-B receptor 3	Homo sapiens (human)
cytosol	Ephrin type-B receptor 3	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 3	Homo sapiens (human)
dendrite	Ephrin type-B receptor 3	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 3	Homo sapiens (human)
rough endoplasmic reticulum	Ephrin type-A receptor 5	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 5	Homo sapiens (human)
external side of plasma membrane	Ephrin type-A receptor 5	Homo sapiens (human)
axon	Ephrin type-A receptor 5	Homo sapiens (human)
dendrite	Ephrin type-A receptor 5	Homo sapiens (human)
neuronal cell body	Ephrin type-A receptor 5	Homo sapiens (human)
perinuclear region of cytoplasm	Ephrin type-A receptor 5	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 5	Homo sapiens (human)
dendrite	Ephrin type-A receptor 5	Homo sapiens (human)
extracellular region	Ephrin type-B receptor 4	Homo sapiens (human)
cytosol	Ephrin type-B receptor 4	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 4	Homo sapiens (human)
extracellular exosome	Ephrin type-B receptor 4	Homo sapiens (human)
receptor complex	Ephrin type-B receptor 4	Homo sapiens (human)
plasma membrane	Ephrin type-B receptor 4	Homo sapiens (human)
cytoplasm	Ephrin type-A receptor 4	Homo sapiens (human)
mitochondrial outer membrane	Ephrin type-A receptor 4	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 4	Homo sapiens (human)
adherens junction	Ephrin type-A receptor 4	Homo sapiens (human)
cell surface	Ephrin type-A receptor 4	Homo sapiens (human)
filopodium	Ephrin type-A receptor 4	Homo sapiens (human)
axon	Ephrin type-A receptor 4	Homo sapiens (human)
dendrite	Ephrin type-A receptor 4	Homo sapiens (human)
neuromuscular junction	Ephrin type-A receptor 4	Homo sapiens (human)
early endosome membrane	Ephrin type-A receptor 4	Homo sapiens (human)
presynaptic membrane	Ephrin type-A receptor 4	Homo sapiens (human)
dendritic spine	Ephrin type-A receptor 4	Homo sapiens (human)
dendritic shaft	Ephrin type-A receptor 4	Homo sapiens (human)
perikaryon	Ephrin type-A receptor 4	Homo sapiens (human)
axon terminus	Ephrin type-A receptor 4	Homo sapiens (human)
axonal growth cone	Ephrin type-A receptor 4	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Ephrin type-A receptor 4	Homo sapiens (human)
postsynaptic density membrane	Ephrin type-A receptor 4	Homo sapiens (human)
glutamatergic synapse	Ephrin type-A receptor 4	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 4	Homo sapiens (human)
dendrite	Ephrin type-A receptor 4	Homo sapiens (human)
mitochondrial intermembrane space	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
extracellular exosome	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
sperm mitochondrial sheath	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
cytoplasm	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
mitochondrion	Adenylate kinase 2, mitochondrial	Homo sapiens (human)
nucleoplasm	Adenosine kinase	Homo sapiens (human)
cytosol	Adenosine kinase	Homo sapiens (human)
plasma membrane	Adenosine kinase	Homo sapiens (human)
nucleus	Adenosine kinase	Homo sapiens (human)
cytosol	Adenosine kinase	Homo sapiens (human)
nucleus	Histone deacetylase 4	Homo sapiens (human)
nucleoplasm	Histone deacetylase 4	Homo sapiens (human)
cytoplasm	Histone deacetylase 4	Homo sapiens (human)
cytosol	Histone deacetylase 4	Homo sapiens (human)
nuclear speck	Histone deacetylase 4	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 4	Homo sapiens (human)
chromatin	Histone deacetylase 4	Homo sapiens (human)
transcription repressor complex	Histone deacetylase 4	Homo sapiens (human)
virion membrane	Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus
exocyst	Ras-related protein Rab-10	Homo sapiens (human)
plasma membrane	Ras-related protein Rab-10	Homo sapiens (human)
Golgi membrane	Ras-related protein Rab-10	Homo sapiens (human)
endosome	Ras-related protein Rab-10	Homo sapiens (human)
endoplasmic reticulum membrane	Ras-related protein Rab-10	Homo sapiens (human)
Golgi apparatus	Ras-related protein Rab-10	Homo sapiens (human)
trans-Golgi network	Ras-related protein Rab-10	Homo sapiens (human)
cytosol	Ras-related protein Rab-10	Homo sapiens (human)
cytoskeleton	Ras-related protein Rab-10	Homo sapiens (human)
plasma membrane	Ras-related protein Rab-10	Homo sapiens (human)
adherens junction	Ras-related protein Rab-10	Homo sapiens (human)
focal adhesion	Ras-related protein Rab-10	Homo sapiens (human)
cilium	Ras-related protein Rab-10	Homo sapiens (human)
endosome membrane	Ras-related protein Rab-10	Homo sapiens (human)
cytoplasmic vesicle membrane	Ras-related protein Rab-10	Homo sapiens (human)
secretory granule membrane	Ras-related protein Rab-10	Homo sapiens (human)
phagocytic vesicle membrane	Ras-related protein Rab-10	Homo sapiens (human)
insulin-responsive compartment	Ras-related protein Rab-10	Homo sapiens (human)
perinuclear region of cytoplasm	Ras-related protein Rab-10	Homo sapiens (human)
recycling endosome	Ras-related protein Rab-10	Homo sapiens (human)
recycling endosome membrane	Ras-related protein Rab-10	Homo sapiens (human)
extracellular exosome	Ras-related protein Rab-10	Homo sapiens (human)
exocytic vesicle	Ras-related protein Rab-10	Homo sapiens (human)
endoplasmic reticulum tubular network	Ras-related protein Rab-10	Homo sapiens (human)
recycling endosome	Ras-related protein Rab-10	Homo sapiens (human)
secretory vesicle	Ras-related protein Rab-10	Homo sapiens (human)
membrane	Ras-related protein Rab-10	Homo sapiens (human)
Golgi apparatus	Ras-related protein Rab-10	Homo sapiens (human)
nucleus	Actin-related protein 3	Homo sapiens (human)
cytoplasm	Actin-related protein 3	Homo sapiens (human)
cytosol	Actin-related protein 3	Homo sapiens (human)
brush border	Actin-related protein 3	Homo sapiens (human)
cell-cell junction	Actin-related protein 3	Homo sapiens (human)
focal adhesion	Actin-related protein 3	Homo sapiens (human)
actin cytoskeleton	Actin-related protein 3	Homo sapiens (human)
membrane	Actin-related protein 3	Homo sapiens (human)
lamellipodium	Actin-related protein 3	Homo sapiens (human)
site of double-strand break	Actin-related protein 3	Homo sapiens (human)
extracellular exosome	Actin-related protein 3	Homo sapiens (human)
Arp2/3 protein complex	Actin-related protein 3	Homo sapiens (human)
extracellular region	Actin-related protein 2	Homo sapiens (human)
nucleus	Actin-related protein 2	Homo sapiens (human)
cytoplasm	Actin-related protein 2	Homo sapiens (human)
cytosol	Actin-related protein 2	Homo sapiens (human)
focal adhesion	Actin-related protein 2	Homo sapiens (human)
actin cytoskeleton	Actin-related protein 2	Homo sapiens (human)
membrane	Actin-related protein 2	Homo sapiens (human)
actin cap	Actin-related protein 2	Homo sapiens (human)
azurophil granule lumen	Actin-related protein 2	Homo sapiens (human)
site of double-strand break	Actin-related protein 2	Homo sapiens (human)
cell projection	Actin-related protein 2	Homo sapiens (human)
extracellular exosome	Actin-related protein 2	Homo sapiens (human)
ficolin-1-rich granule lumen	Actin-related protein 2	Homo sapiens (human)
Arp2/3 protein complex	Actin-related protein 2	Homo sapiens (human)
cell cortex	Actin-related protein 2	Homo sapiens (human)
Flemming body	GTP-binding nuclear protein Ran	Homo sapiens (human)
male germ cell nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
manchette	GTP-binding nuclear protein Ran	Homo sapiens (human)
nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
nuclear envelope	GTP-binding nuclear protein Ran	Homo sapiens (human)
nucleoplasm	GTP-binding nuclear protein Ran	Homo sapiens (human)
nucleolus	GTP-binding nuclear protein Ran	Homo sapiens (human)
cytoplasm	GTP-binding nuclear protein Ran	Homo sapiens (human)
centriole	GTP-binding nuclear protein Ran	Homo sapiens (human)
cytosol	GTP-binding nuclear protein Ran	Homo sapiens (human)
membrane	GTP-binding nuclear protein Ran	Homo sapiens (human)
midbody	GTP-binding nuclear protein Ran	Homo sapiens (human)
sperm flagellum	GTP-binding nuclear protein Ran	Homo sapiens (human)
melanosome	GTP-binding nuclear protein Ran	Homo sapiens (human)
recycling endosome	GTP-binding nuclear protein Ran	Homo sapiens (human)
extracellular exosome	GTP-binding nuclear protein Ran	Homo sapiens (human)
chromatin	GTP-binding nuclear protein Ran	Homo sapiens (human)
nuclear pore	GTP-binding nuclear protein Ran	Homo sapiens (human)
protein-containing complex	GTP-binding nuclear protein Ran	Homo sapiens (human)
RNA nuclear export complex	GTP-binding nuclear protein Ran	Homo sapiens (human)
nucleus	GTP-binding nuclear protein Ran	Homo sapiens (human)
cytoplasm	GTP-binding nuclear protein Ran	Homo sapiens (human)
cytosol	Casein kinase I isoform gamma-2	Homo sapiens (human)
cell cortex	Casein kinase I isoform gamma-2	Homo sapiens (human)
membrane	Casein kinase I isoform gamma-2	Homo sapiens (human)
cytoplasm	Casein kinase I isoform gamma-2	Homo sapiens (human)
plasma membrane	Casein kinase I isoform gamma-2	Homo sapiens (human)
nucleus	Casein kinase I isoform gamma-2	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 3	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 3	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 3	Homo sapiens (human)
ruffle	Cyclin-dependent kinase 6	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 6	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 6	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 6	Homo sapiens (human)
centrosome	Cyclin-dependent kinase 6	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 6	Homo sapiens (human)
cyclin D1-CDK6 complex	Cyclin-dependent kinase 6	Homo sapiens (human)
cyclin D3-CDK6 complex	Cyclin-dependent kinase 6	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 6	Homo sapiens (human)
cyclin D2-CDK6 complex	Cyclin-dependent kinase 6	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 6	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 6	Homo sapiens (human)
microtubule	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent-like kinase 5	Homo sapiens (human)
nucleus	Cyclin-dependent-like kinase 5	Homo sapiens (human)
nucleoplasm	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cytoplasm	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cytosol	Cyclin-dependent-like kinase 5	Homo sapiens (human)
plasma membrane	Cyclin-dependent-like kinase 5	Homo sapiens (human)
postsynaptic density	Cyclin-dependent-like kinase 5	Homo sapiens (human)
membrane	Cyclin-dependent-like kinase 5	Homo sapiens (human)
protein kinase 5 complex	Cyclin-dependent-like kinase 5	Homo sapiens (human)
lamellipodium	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cell junction	Cyclin-dependent-like kinase 5	Homo sapiens (human)
filopodium	Cyclin-dependent-like kinase 5	Homo sapiens (human)
axon	Cyclin-dependent-like kinase 5	Homo sapiens (human)
dendrite	Cyclin-dependent-like kinase 5	Homo sapiens (human)
growth cone	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuromuscular junction	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuron projection	Cyclin-dependent-like kinase 5	Homo sapiens (human)
neuronal cell body	Cyclin-dependent-like kinase 5	Homo sapiens (human)
perikaryon	Cyclin-dependent-like kinase 5	Homo sapiens (human)
presynapse	Cyclin-dependent-like kinase 5	Homo sapiens (human)
nucleus	Cyclin-dependent-like kinase 5	Homo sapiens (human)
cytoplasm	Cyclin-dependent-like kinase 5	Homo sapiens (human)
synaptic vesicle	Cyclin-dependent kinase 16	Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 16	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 16	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 16	Homo sapiens (human)
plasma membrane	Cyclin-dependent kinase 16	Homo sapiens (human)
cytoplasmic side of plasma membrane	Cyclin-dependent kinase 16	Homo sapiens (human)
microtubule cytoskeleton	Cyclin-dependent kinase 16	Homo sapiens (human)
neuron projection	Cyclin-dependent kinase 16	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 16	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 16	Homo sapiens (human)
cytoplasm	Cyclin-dependent kinase 17	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 17	Homo sapiens (human)
nucleus	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
cytoplasm	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
cytosol	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
membrane	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
extracellular exosome	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
membrane	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
6-phosphofructokinase complex	ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)
nucleus	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
mitochondrion	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
early endosome	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
late endosome	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
endoplasmic reticulum	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
Golgi apparatus	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
centrosome	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
cytosol	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
plasma membrane	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
focal adhesion	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-beta	Homo sapiens (human)
heterochromatin	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleus	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleoplasm	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleolus	DNA topoisomerase 2-beta	Homo sapiens (human)
cytosol	DNA topoisomerase 2-beta	Homo sapiens (human)
ribonucleoprotein complex	DNA topoisomerase 2-beta	Homo sapiens (human)
nucleus	DNA topoisomerase 2-beta	Homo sapiens (human)
immunological synapse	Protein kinase C theta type	Homo sapiens (human)
cytosol	Protein kinase C theta type	Homo sapiens (human)
plasma membrane	Protein kinase C theta type	Homo sapiens (human)
aggresome	Protein kinase C theta type	Homo sapiens (human)
centriolar satellite	Protein kinase C theta type	Homo sapiens (human)
plasma membrane	Activin receptor type-1	Homo sapiens (human)
apical part of cell	Activin receptor type-1	Homo sapiens (human)
activin receptor complex	Activin receptor type-1	Homo sapiens (human)
BMP receptor complex	Activin receptor type-1	Homo sapiens (human)
plasma membrane	Activin receptor type-1	Homo sapiens (human)
stress fiber	Macrophage-stimulating protein receptor	Homo sapiens (human)
vacuole	Macrophage-stimulating protein receptor	Homo sapiens (human)
plasma membrane	Macrophage-stimulating protein receptor	Homo sapiens (human)
cell surface	Macrophage-stimulating protein receptor	Homo sapiens (human)
receptor complex	Macrophage-stimulating protein receptor	Homo sapiens (human)
plasma membrane	Macrophage-stimulating protein receptor	Homo sapiens (human)
stress fiber	Focal adhesion kinase 1	Homo sapiens (human)
nucleus	Focal adhesion kinase 1	Homo sapiens (human)
cytoplasm	Focal adhesion kinase 1	Homo sapiens (human)
centrosome	Focal adhesion kinase 1	Homo sapiens (human)
cytosol	Focal adhesion kinase 1	Homo sapiens (human)
cytoskeleton	Focal adhesion kinase 1	Homo sapiens (human)
plasma membrane	Focal adhesion kinase 1	Homo sapiens (human)
focal adhesion	Focal adhesion kinase 1	Homo sapiens (human)
cell cortex	Focal adhesion kinase 1	Homo sapiens (human)
ciliary basal body	Focal adhesion kinase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Focal adhesion kinase 1	Homo sapiens (human)
perinuclear region of cytoplasm	Focal adhesion kinase 1	Homo sapiens (human)
plasma membrane	Focal adhesion kinase 1	Homo sapiens (human)
focal adhesion	Focal adhesion kinase 1	Homo sapiens (human)
dendritic spine	Focal adhesion kinase 1	Homo sapiens (human)
extracellular region	Protein kinase C delta type	Homo sapiens (human)
nucleus	Protein kinase C delta type	Homo sapiens (human)
nucleoplasm	Protein kinase C delta type	Homo sapiens (human)
cytoplasm	Protein kinase C delta type	Homo sapiens (human)
mitochondrion	Protein kinase C delta type	Homo sapiens (human)
endoplasmic reticulum	Protein kinase C delta type	Homo sapiens (human)
cytosol	Protein kinase C delta type	Homo sapiens (human)
plasma membrane	Protein kinase C delta type	Homo sapiens (human)
cell-cell junction	Protein kinase C delta type	Homo sapiens (human)
nuclear matrix	Protein kinase C delta type	Homo sapiens (human)
azurophil granule lumen	Protein kinase C delta type	Homo sapiens (human)
endolysosome	Protein kinase C delta type	Homo sapiens (human)
perinuclear region of cytoplasm	Protein kinase C delta type	Homo sapiens (human)
extracellular exosome	Protein kinase C delta type	Homo sapiens (human)
nucleus	Tyrosine-protein kinase BTK	Homo sapiens (human)
cytoplasm	Tyrosine-protein kinase BTK	Homo sapiens (human)
cytosol	Tyrosine-protein kinase BTK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase BTK	Homo sapiens (human)
cytoplasmic vesicle	Tyrosine-protein kinase BTK	Homo sapiens (human)
membrane raft	Tyrosine-protein kinase BTK	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosine-protein kinase BTK	Homo sapiens (human)
plasma membrane	Tyrosine-protein kinase BTK	Homo sapiens (human)
nucleus	Activated CDC42 kinase 1	Homo sapiens (human)
cytoplasm	Activated CDC42 kinase 1	Homo sapiens (human)
endosome	Activated CDC42 kinase 1	Homo sapiens (human)
cytosol	Activated CDC42 kinase 1	Homo sapiens (human)
plasma membrane	Activated CDC42 kinase 1	Homo sapiens (human)
clathrin-coated pit	Activated CDC42 kinase 1	Homo sapiens (human)
adherens junction	Activated CDC42 kinase 1	Homo sapiens (human)
membrane	Activated CDC42 kinase 1	Homo sapiens (human)
clathrin-coated vesicle	Activated CDC42 kinase 1	Homo sapiens (human)
cytoplasmic vesicle membrane	Activated CDC42 kinase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Activated CDC42 kinase 1	Homo sapiens (human)
perinuclear region of cytoplasm	Activated CDC42 kinase 1	Homo sapiens (human)
cytoophidium	Activated CDC42 kinase 1	Homo sapiens (human)
Grb2-EGFR complex	Activated CDC42 kinase 1	Homo sapiens (human)
plasma membrane	Activated CDC42 kinase 1	Homo sapiens (human)
extracellular space	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
plasma membrane	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
extracellular exosome	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
receptor complex	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
plasma membrane	Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)
plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
cell surface	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
perinuclear region of cytoplasm	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
voltage-gated potassium channel complex	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
inward rectifier potassium channel complex	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
plasma membrane	Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)
Golgi membrane	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
basolateral plasma membrane	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 4	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase 4	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase 4	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 4	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 4	Homo sapiens (human)
nuclear body	Serine/threonine-protein kinase 4	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase 4	Homo sapiens (human)
cytoplasm	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
nucleus	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
nucleoplasm	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cytoplasm	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
cytosol	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
apical plasma membrane	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
nuclear speck	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
axon	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
dendrite	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
nucleotide-activated protein kinase complex	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
neuronal cell body	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
chromatin	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
nucleus	5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)
spindle	Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 7	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 7	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 7	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 7	Homo sapiens (human)
PML body	Mitogen-activated protein kinase 7	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 7	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 7	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cell-cell junction	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
postsynaptic density	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
secretory granule	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
glutamatergic synapse	Serine/threonine-protein kinase PAK 2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 3	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase 3	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase 3	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 3	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase 3	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)
cytosol	Integrin-linked protein kinase	Homo sapiens (human)
plasma membrane	Integrin-linked protein kinase	Homo sapiens (human)
focal adhesion	Integrin-linked protein kinase	Homo sapiens (human)
membrane	Integrin-linked protein kinase	Homo sapiens (human)
sarcomere	Integrin-linked protein kinase	Homo sapiens (human)
lamellipodium	Integrin-linked protein kinase	Homo sapiens (human)
focal adhesion	Integrin-linked protein kinase	Homo sapiens (human)
stress fiber	Integrin-linked protein kinase	Homo sapiens (human)
Golgi membrane	Rho-associated protein kinase 1	Homo sapiens (human)
ruffle	Rho-associated protein kinase 1	Homo sapiens (human)
extracellular region	Rho-associated protein kinase 1	Homo sapiens (human)
centriole	Rho-associated protein kinase 1	Homo sapiens (human)
cytosol	Rho-associated protein kinase 1	Homo sapiens (human)
cytoskeleton	Rho-associated protein kinase 1	Homo sapiens (human)
plasma membrane	Rho-associated protein kinase 1	Homo sapiens (human)
cytoplasmic stress granule	Rho-associated protein kinase 1	Homo sapiens (human)
lamellipodium	Rho-associated protein kinase 1	Homo sapiens (human)
bleb	Rho-associated protein kinase 1	Homo sapiens (human)
secretory granule lumen	Rho-associated protein kinase 1	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Rho-associated protein kinase 1	Homo sapiens (human)
cytoskeleton	Rho-associated protein kinase 1	Homo sapiens (human)
cytoplasm	Rho-associated protein kinase 1	Homo sapiens (human)
cytoplasmic stress granule	Rho-associated protein kinase 1	Homo sapiens (human)
cytoplasm	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
membrane	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
plasma membrane	Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)
nucleus	Histone deacetylase 1	Homo sapiens (human)
nucleoplasm	Histone deacetylase 1	Homo sapiens (human)
cytoplasm	Histone deacetylase 1	Homo sapiens (human)
cytosol	Histone deacetylase 1	Homo sapiens (human)
NuRD complex	Histone deacetylase 1	Homo sapiens (human)
neuronal cell body	Histone deacetylase 1	Homo sapiens (human)
Sin3-type complex	Histone deacetylase 1	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 1	Homo sapiens (human)
chromatin	Histone deacetylase 1	Homo sapiens (human)
heterochromatin	Histone deacetylase 1	Homo sapiens (human)
transcription repressor complex	Histone deacetylase 1	Homo sapiens (human)
protein-containing complex	Histone deacetylase 1	Homo sapiens (human)
nucleus	Histone deacetylase 1	Homo sapiens (human)
nucleoplasm	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
cytosol	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
membrane	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
endocytic vesicle membrane	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
sarcoplasmic reticulum membrane	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
calcium- and calmodulin-dependent protein kinase complex	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
neuron projection	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
cytoplasm	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)
nucleus	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
nucleoplasm	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cytoplasm	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cytosol	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
membrane	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
endocytic vesicle membrane	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
sarcoplasmic reticulum membrane	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
sarcolemma	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
calcium- and calmodulin-dependent protein kinase complex	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cytoplasm	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
neuron projection	Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)
cytoskeleton	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
nucleus	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
nucleus	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
nucleoplasm	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
cytoplasm	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
nuclear speck	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
axon	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
dendrite	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
ribonucleoprotein complex	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)
cytoplasm	Activin receptor type-2B	Homo sapiens (human)
plasma membrane	Activin receptor type-2B	Homo sapiens (human)
protein-containing complex	Activin receptor type-2B	Homo sapiens (human)
receptor complex	Activin receptor type-2B	Homo sapiens (human)
activin receptor complex	Activin receptor type-2B	Homo sapiens (human)
plasma membrane	Activin receptor type-2B	Homo sapiens (human)
caveola	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
extracellular space	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
nucleoplasm	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
plasma membrane	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
clathrin-coated pit	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
adherens junction	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
basal plasma membrane	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
cell surface	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
postsynaptic density	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
apical plasma membrane	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
axon	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
dendrite	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
neuronal cell body	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
plasma membrane	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
receptor complex	Bone morphogenetic protein receptor type-2	Homo sapiens (human)
ruffle	Protein-tyrosine kinase 6	Homo sapiens (human)
nucleus	Protein-tyrosine kinase 6	Homo sapiens (human)
nucleoplasm	Protein-tyrosine kinase 6	Homo sapiens (human)
cytoplasm	Protein-tyrosine kinase 6	Homo sapiens (human)
cytosol	Protein-tyrosine kinase 6	Homo sapiens (human)
plasma membrane	Protein-tyrosine kinase 6	Homo sapiens (human)
nuclear body	Protein-tyrosine kinase 6	Homo sapiens (human)
plasma membrane	Protein-tyrosine kinase 6	Homo sapiens (human)
acrosomal vesicle	cGMP-dependent protein kinase 1	Homo sapiens (human)
nucleoplasm	cGMP-dependent protein kinase 1	Homo sapiens (human)
cytoplasm	cGMP-dependent protein kinase 1	Homo sapiens (human)
Golgi apparatus	cGMP-dependent protein kinase 1	Homo sapiens (human)
cytosol	cGMP-dependent protein kinase 1	Homo sapiens (human)
plasma membrane	cGMP-dependent protein kinase 1	Homo sapiens (human)
sarcolemma	cGMP-dependent protein kinase 1	Homo sapiens (human)
cyclin K-CDK13 complex	Cyclin-dependent kinase 13	Homo sapiens (human)
extracellular region	Cyclin-dependent kinase 13	Homo sapiens (human)
extracellular space	Cyclin-dependent kinase 13	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 13	Homo sapiens (human)
Golgi apparatus	Cyclin-dependent kinase 13	Homo sapiens (human)
cytosol	Cyclin-dependent kinase 13	Homo sapiens (human)
nuclear speck	Cyclin-dependent kinase 13	Homo sapiens (human)
ficolin-1-rich granule lumen	Cyclin-dependent kinase 13	Homo sapiens (human)
nuclear cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 13	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 13	Homo sapiens (human)
cyclin/CDK positive transcription elongation factor complex	Cyclin-dependent kinase 13	Homo sapiens (human)
cytoplasm	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
nucleus	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
nucleoplasm	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
cytoplasm	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
cytosol	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
PML body	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
mitochondrial membrane	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
serine/threonine protein kinase complex	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)
NMDA selective glutamate receptor complex	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
nucleus	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cytoplasm	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cytosol	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cytoskeleton	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
focal adhesion	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cell cortex	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
postsynaptic density	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
lamellipodium	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
dendrite	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
growth cone	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
neuronal cell body	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
cell body	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
perinuclear region of cytoplasm	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
apical dendrite	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
presynapse	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
glutamatergic synapse	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
postsynaptic density, intracellular component	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
dendritic spine	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
focal adhesion	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
plasma membrane	Protein-tyrosine kinase 2-beta	Homo sapiens (human)
plasma membrane	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
cell cortex	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
membrane	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
cytoplasm	Maternal embryonic leucine zipper kinase	Homo sapiens (human)
chromosome, centromeric region	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
kinetochore	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
condensed nuclear chromosome	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
nucleus	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
nucleoplasm	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
chromosome	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
cytosol	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
nuclear matrix	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
mitotic cohesin complex	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
meiotic cohesin complex	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
mitotic spindle pole	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
cohesin complex	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
nucleus	Structural maintenance of chromosomes protein 1A	Homo sapiens (human)
chromosome, telomeric region	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
nucleus	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
nucleoplasm	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
cytoplasm	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
centrosome	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
membrane	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
NuRD complex	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
site of DNA damage	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
cerebellar granule cell to Purkinje cell synapse	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
chromatin	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
protein-containing complex	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
nucleus	Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)
peroxisome	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
peroxisome	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
peroxisomal membrane	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
peroxisomal matrix	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
cytosol	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
membrane	Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)
site of double-strand break	Serine/threonine-protein kinase 38	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase 38	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 38	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 38	Homo sapiens (human)
glutamatergic synapse	Serine/threonine-protein kinase 38	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
extracellular region	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
nucleus	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
nucleoplasm	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
mitochondrion	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
mitochondrial matrix	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
cytosol	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
plasma membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
basolateral plasma membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
neuromuscular junction	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
presynaptic membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
postsynaptic membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
postsynaptic density membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
glutamatergic synapse	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
GABA-ergic synapse	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
receptor complex	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
basal plasma membrane	Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 7	Homo sapiens (human)
glutamatergic synapse	Ephrin type-A receptor 7	Homo sapiens (human)
plasma membrane	Ephrin type-A receptor 7	Homo sapiens (human)
dendrite	Ephrin type-A receptor 7	Homo sapiens (human)
Golgi membrane	Delta(24)-sterol reductase	Homo sapiens (human)
nucleus	Delta(24)-sterol reductase	Homo sapiens (human)
endoplasmic reticulum	Delta(24)-sterol reductase	Homo sapiens (human)
endoplasmic reticulum membrane	Delta(24)-sterol reductase	Homo sapiens (human)
membrane	Delta(24)-sterol reductase	Homo sapiens (human)
cytoplasm	Delta(24)-sterol reductase	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
cytosol	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
synapse	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)
stress fiber	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cytoplasm	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cytosol	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
plasma membrane	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
actin cytoskeleton	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
lamellipodium	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cleavage furrow	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cleavage furrow	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
stress fiber	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
lamellipodium	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
cytoplasm	Myosin light chain kinase, smooth muscle	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 11	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 11	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 11	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 11	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase STK11	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase STK11	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase STK11	Homo sapiens (human)
mitochondrion	Serine/threonine-protein kinase STK11	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase STK11	Homo sapiens (human)
membrane	Serine/threonine-protein kinase STK11	Homo sapiens (human)
Z disc	Serine/threonine-protein kinase STK11	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase STK11	Homo sapiens (human)
serine/threonine protein kinase complex	Serine/threonine-protein kinase STK11	Homo sapiens (human)
intracellular protein-containing complex	Serine/threonine-protein kinase STK11	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase STK11	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase STK11	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase N1	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase N1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase N1	Homo sapiens (human)
endosome	Serine/threonine-protein kinase N1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase N1	Homo sapiens (human)
midbody	Serine/threonine-protein kinase N1	Homo sapiens (human)
cleavage furrow	Serine/threonine-protein kinase N1	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase N1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase N2	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase N2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase N2	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase N2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase N2	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase N2	Homo sapiens (human)
nuclear body	Serine/threonine-protein kinase N2	Homo sapiens (human)
lamellipodium	Serine/threonine-protein kinase N2	Homo sapiens (human)
midbody	Serine/threonine-protein kinase N2	Homo sapiens (human)
cleavage furrow	Serine/threonine-protein kinase N2	Homo sapiens (human)
apical junction complex	Serine/threonine-protein kinase N2	Homo sapiens (human)
intermediate filament cytoskeleton	Serine/threonine-protein kinase N2	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase N2	Homo sapiens (human)
protein-containing complex	Serine/threonine-protein kinase N2	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 14	Homo sapiens (human)
spindle pole	Mitogen-activated protein kinase 14	Homo sapiens (human)
extracellular region	Mitogen-activated protein kinase 14	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 14	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase 14	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 14	Homo sapiens (human)
mitochondrion	Mitogen-activated protein kinase 14	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase 14	Homo sapiens (human)
nuclear speck	Mitogen-activated protein kinase 14	Homo sapiens (human)
secretory granule lumen	Mitogen-activated protein kinase 14	Homo sapiens (human)
glutamatergic synapse	Mitogen-activated protein kinase 14	Homo sapiens (human)
ficolin-1-rich granule lumen	Mitogen-activated protein kinase 14	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 14	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 14	Homo sapiens (human)
fibrillar center	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
nucleoplasm	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
extracellular exosome	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
cytoplasm	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
nucleus	Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)
centrosome	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
microtubule	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
membrane	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
centrosome	Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)
nucleoplasm	MAP kinase-activated protein kinase 3	Homo sapiens (human)
cytosol	MAP kinase-activated protein kinase 3	Homo sapiens (human)
cytoplasm	MAP kinase-activated protein kinase 3	Homo sapiens (human)
nucleus	MAP kinase-activated protein kinase 3	Homo sapiens (human)
plasma membrane	Discoidin domain-containing receptor 2	Homo sapiens (human)
focal adhesion	Discoidin domain-containing receptor 2	Homo sapiens (human)
actin cytoskeleton	Discoidin domain-containing receptor 2	Homo sapiens (human)
apical plasma membrane	Discoidin domain-containing receptor 2	Homo sapiens (human)
receptor complex	Discoidin domain-containing receptor 2	Homo sapiens (human)
plasma membrane	Discoidin domain-containing receptor 2	Homo sapiens (human)
cytosol	AP2-associated protein kinase 1	Homo sapiens (human)
plasma membrane	AP2-associated protein kinase 1	Homo sapiens (human)
clathrin-coated pit	AP2-associated protein kinase 1	Homo sapiens (human)
clathrin-coated vesicle	AP2-associated protein kinase 1	Homo sapiens (human)
cell leading edge	AP2-associated protein kinase 1	Homo sapiens (human)
terminal bouton	AP2-associated protein kinase 1	Homo sapiens (human)
intracellular membrane-bounded organelle	AP2-associated protein kinase 1	Homo sapiens (human)
presynapse	AP2-associated protein kinase 1	Homo sapiens (human)
cytoplasm	Myosin light chain kinase 3	Homo sapiens (human)
cytosol	Myosin light chain kinase 3	Homo sapiens (human)
cytoplasm	Myosin light chain kinase 3	Homo sapiens (human)
actin cytoskeleton	Myosin light chain kinase 3	Homo sapiens (human)
extracellular exosome	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
perinuclear region of cytoplasm	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
protein-containing complex	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
plasma membrane	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
cytosol	Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cell-cell junction	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
lamellipodium	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cell leading edge	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
actomyosin	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
actomyosin	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cytoskeleton	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
cell leading edge	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
centriolar satellite	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
cytoskeleton	Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)
mitochondrion	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
mitochondrial matrix	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
cytoplasm	Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase N3	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase N3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase N3	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase N3	Homo sapiens (human)
phagophore assembly site	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
ciliary tip	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
phagophore assembly site membrane	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
autophagosome	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
phagophore assembly site	Serine/threonine-protein kinase ULK3	Homo sapiens (human)
endoplasmic reticulum	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
endoplasmic reticulum quality control compartment	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
IRE1-TRAF2-ASK1 complex	Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
mitochondrion	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
actin filament	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
membrane	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
lateral plasma membrane	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
dendrite	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
microtubule bundle	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase MARK2	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
mitochondrion	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
cytosol	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
ribonucleoprotein granule	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
mitochondrial nucleoid	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
intracellular anatomical structure	ATP-dependent RNA helicase DHX30	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
microtubule cytoskeleton	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase TAO1	Homo sapiens (human)
nucleus	STE20-related kinase adapter protein alpha	Homo sapiens (human)
nucleoplasm	STE20-related kinase adapter protein alpha	Homo sapiens (human)
cytoplasm	STE20-related kinase adapter protein alpha	Homo sapiens (human)
cytosol	STE20-related kinase adapter protein alpha	Homo sapiens (human)
serine/threonine protein kinase complex	STE20-related kinase adapter protein alpha	Homo sapiens (human)
intracellular protein-containing complex	STE20-related kinase adapter protein alpha	Homo sapiens (human)
stress fiber	Myosin-14	Homo sapiens (human)
cytosol	Myosin-14	Homo sapiens (human)
brush border	Myosin-14	Homo sapiens (human)
membrane	Myosin-14	Homo sapiens (human)
growth cone	Myosin-14	Homo sapiens (human)
actomyosin	Myosin-14	Homo sapiens (human)
extracellular exosome	Myosin-14	Homo sapiens (human)
myosin II filament	Myosin-14	Homo sapiens (human)
myosin II complex	Myosin-14	Homo sapiens (human)
cytoplasm	Myosin-14	Homo sapiens (human)
myosin filament	Myosin-14	Homo sapiens (human)
mitochondrion	AarF domain-containing protein kinase 1	Homo sapiens (human)
mitochondrial inner membrane	AarF domain-containing protein kinase 1	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
nucleoplasm	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
cytosol	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
Cajal body	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
membrane	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
nuclear speck	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
U2-type prespliceosome	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DDX42	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)
nucleoplasm	MAP kinase-activated protein kinase 5	Homo sapiens (human)
cytosol	MAP kinase-activated protein kinase 5	Homo sapiens (human)
septin cytoskeleton	MAP kinase-activated protein kinase 5	Homo sapiens (human)
protein-containing complex	MAP kinase-activated protein kinase 5	Homo sapiens (human)
cytoplasm	MAP kinase-activated protein kinase 5	Homo sapiens (human)
nucleus	MAP kinase-activated protein kinase 5	Homo sapiens (human)
cytosol	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
translation release factor complex	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)
cytoplasm	Misshapen-like kinase 1	Homo sapiens (human)
Golgi apparatus	Misshapen-like kinase 1	Homo sapiens (human)
cytosol	Misshapen-like kinase 1	Homo sapiens (human)
postsynaptic density	Misshapen-like kinase 1	Homo sapiens (human)
axon	Misshapen-like kinase 1	Homo sapiens (human)
dendrite	Misshapen-like kinase 1	Homo sapiens (human)
extracellular exosome	Misshapen-like kinase 1	Homo sapiens (human)
cytoplasm	Misshapen-like kinase 1	Homo sapiens (human)
mitochondrion	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
membrane	Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)
nucleoplasm	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
autophagosome	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
endoplasmic reticulum	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
cytosol	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
intracellular organelle	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
extracellular exosome	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
plasma membrane	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)
axoneme	Mitogen-activated protein kinase 15	Homo sapiens (human)
extracellular region	Mitogen-activated protein kinase 15	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 15	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 15	Homo sapiens (human)
autophagosome	Mitogen-activated protein kinase 15	Homo sapiens (human)
Golgi apparatus	Mitogen-activated protein kinase 15	Homo sapiens (human)
centriole	Mitogen-activated protein kinase 15	Homo sapiens (human)
cell-cell junction	Mitogen-activated protein kinase 15	Homo sapiens (human)
bicellular tight junction	Mitogen-activated protein kinase 15	Homo sapiens (human)
cytoplasmic vesicle	Mitogen-activated protein kinase 15	Homo sapiens (human)
ciliary basal body	Mitogen-activated protein kinase 15	Homo sapiens (human)
meiotic spindle	Mitogen-activated protein kinase 15	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase 15	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase 15	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase Nek9	Homo sapiens (human)
microtubule organizing center	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
spindle pole	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
microtubule	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Nek7	Homo sapiens (human)
nucleus	Histone deacetylase 7	Homo sapiens (human)
nucleoplasm	Histone deacetylase 7	Homo sapiens (human)
cytoplasm	Histone deacetylase 7	Homo sapiens (human)
cytosol	Histone deacetylase 7	Homo sapiens (human)
nucleus	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
nucleoplasm	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
cytoplasm	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
mitochondrion	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
cytosol	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
cytoplasmic stress granule	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
membrane	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
cleavage body	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
tRNA-splicing ligase complex	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
ribonucleoprotein complex	ATP-dependent RNA helicase DDX1	Homo sapiens (human)
fibrillar center	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytosol	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
nucleus	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
cytoplasm	Inositol hexakisphosphate kinase 1	Homo sapiens (human)
chromosome, telomeric region	Histone deacetylase 2	Homo sapiens (human)
nucleus	Histone deacetylase 2	Homo sapiens (human)
nucleoplasm	Histone deacetylase 2	Homo sapiens (human)
cytoplasm	Histone deacetylase 2	Homo sapiens (human)
NuRD complex	Histone deacetylase 2	Homo sapiens (human)
Sin3-type complex	Histone deacetylase 2	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 2	Homo sapiens (human)
chromatin	Histone deacetylase 2	Homo sapiens (human)
protein-containing complex	Histone deacetylase 2	Homo sapiens (human)
ESC/E(Z) complex	Histone deacetylase 2	Homo sapiens (human)
nucleus	Histone deacetylase 2	Homo sapiens (human)
membrane	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)
nucleus	Polyamine deacetylase HDAC10	Homo sapiens (human)
nucleoplasm	Polyamine deacetylase HDAC10	Homo sapiens (human)
cytoplasm	Polyamine deacetylase HDAC10	Homo sapiens (human)
cytosol	Polyamine deacetylase HDAC10	Homo sapiens (human)
intracellular membrane-bounded organelle	Polyamine deacetylase HDAC10	Homo sapiens (human)
histone deacetylase complex	Polyamine deacetylase HDAC10	Homo sapiens (human)
nucleus	Histone deacetylase 11	Homo sapiens (human)
plasma membrane	Histone deacetylase 11	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 11	Homo sapiens (human)
kinetochore	Aurora kinase B	Homo sapiens (human)
condensed chromosome, centromeric region	Aurora kinase B	Homo sapiens (human)
nucleus	Aurora kinase B	Homo sapiens (human)
nucleoplasm	Aurora kinase B	Homo sapiens (human)
spindle	Aurora kinase B	Homo sapiens (human)
cytosol	Aurora kinase B	Homo sapiens (human)
chromocenter	Aurora kinase B	Homo sapiens (human)
microtubule cytoskeleton	Aurora kinase B	Homo sapiens (human)
midbody	Aurora kinase B	Homo sapiens (human)
chromosome passenger complex	Aurora kinase B	Homo sapiens (human)
mitotic spindle pole	Aurora kinase B	Homo sapiens (human)
mitotic spindle midzone	Aurora kinase B	Homo sapiens (human)
kinetochore	Aurora kinase B	Homo sapiens (human)
spindle pole centrosome	Aurora kinase B	Homo sapiens (human)
spindle microtubule	Aurora kinase B	Homo sapiens (human)
spindle midzone	Aurora kinase B	Homo sapiens (human)
microtubule organizing center	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cytoplasm	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
centrosome	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
microtubule organizing center	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cytosol	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
microtubule cytoskeleton	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
dendrite	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
midbody	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
neuron projection	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
gamma-tubulin complex	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
ciliary basal body	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
cytoplasm	MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)
Golgi membrane	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
plasma membrane	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
calcium- and calmodulin-dependent protein kinase complex	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
intracellular anatomical structure	Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)
pericentriolar material	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
centrosome	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
centriolar satellite	Serine/threonine-protein kinase Nek1	Homo sapiens (human)
nucleoplasm	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
cytosol	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
neuron projection	Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)
nucleus	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
nucleoplasm	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
cytoplasm	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
EKC/KEOPS complex	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
cytosol	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
nucleus	EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)
nucleus	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
nucleoplasm	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
nuclear body	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
nucleus	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
cytoplasm	Dual specificity testis-specific protein kinase 2	Homo sapiens (human)
Golgi membrane	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
nucleoplasm	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
nucleolus	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
endoplasmic reticulum	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
endoplasmic reticulum membrane	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
Golgi apparatus	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
cytosol	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
membrane	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
cytoplasm	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
nucleus	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
external side of plasma membrane	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein-containing complex	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
protein kinase complex	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
IRE1-TRAF2-ASK1 complex	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)
cytosol	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
cytosol	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
nucleus	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
cytoplasm	Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)
nuclear chromosome	Histone deacetylase 8	Homo sapiens (human)
nucleus	Histone deacetylase 8	Homo sapiens (human)
nucleoplasm	Histone deacetylase 8	Homo sapiens (human)
cytoplasm	Histone deacetylase 8	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 8	Homo sapiens (human)
nucleus	Histone deacetylase 8	Homo sapiens (human)
nucleus	Nucleolar GTP-binding protein 1	Homo sapiens (human)
nucleoplasm	Nucleolar GTP-binding protein 1	Homo sapiens (human)
nucleolus	Nucleolar GTP-binding protein 1	Homo sapiens (human)
cytoplasm	Nucleolar GTP-binding protein 1	Homo sapiens (human)
cytosol	Nucleolar GTP-binding protein 1	Homo sapiens (human)
membrane	Nucleolar GTP-binding protein 1	Homo sapiens (human)
nuclear membrane	Nucleolar GTP-binding protein 1	Homo sapiens (human)
perinuclear region of cytoplasm	Nucleolar GTP-binding protein 1	Homo sapiens (human)
nucleolus	Nucleolar GTP-binding protein 1	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase D2	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase D2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase D2	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase D2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D2	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase D2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase D2	Homo sapiens (human)
chromosome, telomeric region	RNA cytidine acetyltransferase	Homo sapiens (human)
nucleus	RNA cytidine acetyltransferase	Homo sapiens (human)
nucleoplasm	RNA cytidine acetyltransferase	Homo sapiens (human)
nucleolus	RNA cytidine acetyltransferase	Homo sapiens (human)
membrane	RNA cytidine acetyltransferase	Homo sapiens (human)
midbody	RNA cytidine acetyltransferase	Homo sapiens (human)
telomerase holoenzyme complex	RNA cytidine acetyltransferase	Homo sapiens (human)
small-subunit processome	RNA cytidine acetyltransferase	Homo sapiens (human)
nucleolus	RNA cytidine acetyltransferase	Homo sapiens (human)
endoplasmic reticulum membrane	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase SIK2	Homo sapiens (human)
cytoplasm	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
cytosol	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
cell leading edge	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
perinuclear region of cytoplasm	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
extracellular exosome	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
cytoplasm	STE20-like serine/threonine-protein kinase	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase TAO3	Homo sapiens (human)
nucleus	dCTP pyrophosphatase 1	Homo sapiens (human)
nucleoplasm	dCTP pyrophosphatase 1	Homo sapiens (human)
mitochondrion	dCTP pyrophosphatase 1	Homo sapiens (human)
cytosol	dCTP pyrophosphatase 1	Homo sapiens (human)
cytosol	dCTP pyrophosphatase 1	Homo sapiens (human)
nucleus	Dual specificity protein kinase CLK4	Homo sapiens (human)
cytoplasm	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule organizing center	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
cytosol	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
microtubule cytoskeleton	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
membrane	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
midbody	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
mitotic spindle	Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)
cytosol	Casein kinase I isoform gamma-1	Homo sapiens (human)
nucleus	Casein kinase I isoform gamma-1	Homo sapiens (human)
plasma membrane	Casein kinase I isoform gamma-1	Homo sapiens (human)
cytoplasm	Casein kinase I isoform gamma-1	Homo sapiens (human)
cytoplasm	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
cytosol	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
phenylalanine-tRNA ligase complex	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
membrane	Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)
mitochondrial matrix	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
mitochondrion	Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)
nuclear speck	BMP-2-inducible protein kinase	Homo sapiens (human)
cytoplasm	BMP-2-inducible protein kinase	Homo sapiens (human)
nucleus	BMP-2-inducible protein kinase	Homo sapiens (human)
extracellular region	Obg-like ATPase 1	Homo sapiens (human)
nucleolus	Obg-like ATPase 1	Homo sapiens (human)
cytoplasm	Obg-like ATPase 1	Homo sapiens (human)
centrosome	Obg-like ATPase 1	Homo sapiens (human)
cytosol	Obg-like ATPase 1	Homo sapiens (human)
membrane	Obg-like ATPase 1	Homo sapiens (human)
platelet alpha granule lumen	Obg-like ATPase 1	Homo sapiens (human)
extracellular exosome	Obg-like ATPase 1	Homo sapiens (human)
cytoplasm	Obg-like ATPase 1	Homo sapiens (human)
nucleus	Midasin	Homo sapiens (human)
nucleoplasm	Midasin	Homo sapiens (human)
nucleolus	Midasin	Homo sapiens (human)
cytosol	Midasin	Homo sapiens (human)
membrane	Midasin	Homo sapiens (human)
intermediate filament cytoskeleton	Midasin	Homo sapiens (human)
nucleus	Midasin	Homo sapiens (human)
preribosome, large subunit precursor	Midasin	Homo sapiens (human)
cytoplasm	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
cell surface	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
extrinsic component of plasma membrane	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
extracellular space	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
cytosol	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
plasma membrane	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
endosome membrane	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
nucleus	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
plasma membrane	Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)
nucleus	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)
cyclin K-CDK12 complex	Cyclin-dependent kinase 12	Homo sapiens (human)
nucleoplasm	Cyclin-dependent kinase 12	Homo sapiens (human)
nuclear speck	Cyclin-dependent kinase 12	Homo sapiens (human)
nuclear cyclin-dependent protein kinase holoenzyme complex	Cyclin-dependent kinase 12	Homo sapiens (human)
nucleus	Cyclin-dependent kinase 12	Homo sapiens (human)
cyclin/CDK positive transcription elongation factor complex	Cyclin-dependent kinase 12	Homo sapiens (human)
nucleoplasm	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
cytoplasm	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrion	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrial inner membrane	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrial respirasome	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrial respiratory chain complex I	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
mitochondrial membrane	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 26	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase 26	Homo sapiens (human)
Golgi-associated vesicle	Serine/threonine-protein kinase 26	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase 26	Homo sapiens (human)
vesicle membrane	Serine/threonine-protein kinase 26	Homo sapiens (human)
membrane	Serine/threonine-protein kinase 26	Homo sapiens (human)
apical plasma membrane	Serine/threonine-protein kinase 26	Homo sapiens (human)
perinuclear region of cytoplasm	Serine/threonine-protein kinase 26	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase 26	Homo sapiens (human)
cell periphery	Serine/threonine-protein kinase 26	Homo sapiens (human)
FAR/SIN/STRIPAK complex	Serine/threonine-protein kinase 26	Homo sapiens (human)
Golgi apparatus	Serine/threonine-protein kinase 26	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase 26	Homo sapiens (human)
mitochondrion	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
mitochondrial matrix	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinate-CoA ligase complex (ADP-forming)	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
extracellular exosome	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
mitochondrion	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
succinate-CoA ligase complex	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase NLK	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase NLK	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase NLK	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase NLK	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase NLK	Homo sapiens (human)
nucleus	Histone deacetylase 6	Homo sapiens (human)
nucleoplasm	Histone deacetylase 6	Homo sapiens (human)
cytoplasm	Histone deacetylase 6	Homo sapiens (human)
multivesicular body	Histone deacetylase 6	Homo sapiens (human)
centrosome	Histone deacetylase 6	Homo sapiens (human)
cytosol	Histone deacetylase 6	Homo sapiens (human)
microtubule	Histone deacetylase 6	Homo sapiens (human)
caveola	Histone deacetylase 6	Homo sapiens (human)
inclusion body	Histone deacetylase 6	Homo sapiens (human)
aggresome	Histone deacetylase 6	Homo sapiens (human)
axon	Histone deacetylase 6	Homo sapiens (human)
dendrite	Histone deacetylase 6	Homo sapiens (human)
cell leading edge	Histone deacetylase 6	Homo sapiens (human)
ciliary basal body	Histone deacetylase 6	Homo sapiens (human)
perikaryon	Histone deacetylase 6	Homo sapiens (human)
perinuclear region of cytoplasm	Histone deacetylase 6	Homo sapiens (human)
axon cytoplasm	Histone deacetylase 6	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 6	Homo sapiens (human)
microtubule associated complex	Histone deacetylase 6	Homo sapiens (human)
extracellular space	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
nucleoplasm	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cytosol	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
nucleotide-activated protein kinase complex	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cytoplasm	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
nucleus	5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
intracellular membrane-bounded organelle	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
serine/threonine protein kinase complex	Serine/threonine-protein kinase TBK1	Homo sapiens (human)
stress fiber	Septin-9	Homo sapiens (human)
cytoplasm	Septin-9	Homo sapiens (human)
microtubule	Septin-9	Homo sapiens (human)
axoneme	Septin-9	Homo sapiens (human)
actin cytoskeleton	Septin-9	Homo sapiens (human)
perinuclear region of cytoplasm	Septin-9	Homo sapiens (human)
non-motile cilium	Septin-9	Homo sapiens (human)
septin complex	Septin-9	Homo sapiens (human)
septin ring	Septin-9	Homo sapiens (human)
microtubule cytoskeleton	Septin-9	Homo sapiens (human)
cell division site	Septin-9	Homo sapiens (human)
fibrillar center	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
nucleolus	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
mitochondrion	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
cytosol	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
cytoplasm	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
nucleoplasm	Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)
nucleus	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
nucleoplasm	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
cytoplasm	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
cytosol	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
cytoskeleton	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
apical plasma membrane	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
recycling endosome	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
extracellular exosome	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
presynapse	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
glutamatergic synapse	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
postsynaptic density, intracellular component	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
cytoplasm	TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)
nucleus	Histone deacetylase 9	Homo sapiens (human)
nucleoplasm	Histone deacetylase 9	Homo sapiens (human)
cytoplasm	Histone deacetylase 9	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 9	Homo sapiens (human)
transcription regulator complex	Histone deacetylase 9	Homo sapiens (human)
histone methyltransferase complex	Histone deacetylase 9	Homo sapiens (human)
actin cytoskeleton	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
nucleoplasm	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
nucleolus	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
axon	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
cytoplasmic vesicle membrane	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
cytoplasmic vesicle	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
neuron projection	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
dendritic growth cone	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
axonal growth cone	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
receptor complex	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase TAO2	Homo sapiens (human)
plasma membrane	ALK tyrosine kinase receptor	Homo sapiens (human)
plasma membrane	ALK tyrosine kinase receptor	Homo sapiens (human)
extracellular exosome	ALK tyrosine kinase receptor	Homo sapiens (human)
protein-containing complex	ALK tyrosine kinase receptor	Homo sapiens (human)
receptor complex	ALK tyrosine kinase receptor	Homo sapiens (human)
fibrillar center	Serine/threonine-protein kinase ICK	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase ICK	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase ICK	Homo sapiens (human)
cilium	Serine/threonine-protein kinase ICK	Homo sapiens (human)
ciliary basal body	Serine/threonine-protein kinase ICK	Homo sapiens (human)
ciliary tip	Serine/threonine-protein kinase ICK	Homo sapiens (human)
ciliary base	Serine/threonine-protein kinase ICK	Homo sapiens (human)
nucleus	Serine/threonine-protein kinase ICK	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase ICK	Homo sapiens (human)
cilium	Serine/threonine-protein kinase ICK	Homo sapiens (human)
nucleus	Histone deacetylase 5	Homo sapiens (human)
nucleoplasm	Histone deacetylase 5	Homo sapiens (human)
cytoplasm	Histone deacetylase 5	Homo sapiens (human)
Golgi apparatus	Histone deacetylase 5	Homo sapiens (human)
cytosol	Histone deacetylase 5	Homo sapiens (human)
nuclear speck	Histone deacetylase 5	Homo sapiens (human)
histone deacetylase complex	Histone deacetylase 5	Homo sapiens (human)
nucleus	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
cytoplasm	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
membrane	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
nucleoplasm	RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase SIK3	Homo sapiens (human)
nucleoplasm	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)
exon-exon junction complex	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nucleus	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nucleoplasm	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
nuclear speck	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
extracellular exosome	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
mediator complex	Thyroid hormone receptor-associated protein 3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
cytosol	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
plasma membrane	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)
nucleus	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
nucleus	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
cytosol	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
protein-containing complex	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
cytoplasm	Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)
cytosol	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
plasma membrane	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cell-cell junction	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
lamellipodium	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cell leading edge	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
actomyosin	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
extracellular exosome	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cytoskeleton	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
cytoplasm	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
actomyosin	Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)
nucleus	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
cytoplasm	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
nucleus	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
plasma membrane	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
cytoplasm	Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)
cytoplasm	Casein kinase I isoform gamma-3	Homo sapiens (human)
plasma membrane	Casein kinase I isoform gamma-3	Homo sapiens (human)
cytoplasm	Casein kinase I isoform gamma-3	Homo sapiens (human)
nucleus	Casein kinase I isoform gamma-3	Homo sapiens (human)
cytoplasm	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
perinuclear region of cytoplasm	Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1179)

Assay ID	Title	Year	Journal	Article
AID1425052	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1848538	Selectivity index, ratio of IC50 for N-terminal GST-tagged human recombinant wild type EGFR (695 to end residues) expressed in baculovirus-infected Sf9 cells to IC50 for N-terminal GST-tagged human recombinant EGFR T790M/L858R mutant (695 to end residues)
AID1458988	Efflux ratio of apparent permeability from basolateral side to apical side over apical side to basolateral side over in human Caco2 cells at 5 uM incubated for 2 hrs	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1585323	Toxicity in castrated nude mouse xenografted with human PC9 cells assessed as body weight loss at 10 mg/kg, po daily for 14 consecutive days relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425085	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167104	Lipophilicity, log D of the compound at pH 7.4	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1815230	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability measured by MTT assay	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1730481	Intrinsic clearance in human liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1424977	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519431	Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 0.462 uM after 24 hrs by propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 22.24 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1424957	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425010	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1434570	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by SRB assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR
AID1424954	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1483368	Inhibition of EGFR L858R mutant (unknown origin)	2017	Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11	Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.
AID1730490	Drug metabolism in cynomolgus monkey liver microsomes assessed as AZ5104 metabolite levels preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1872388	Inhibition of cell growth in human Lymphoma cell line bearing wildtype EZH2	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.
AID1425209	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1617468	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M/C797S mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo ki	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
AID1424912	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583855	Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay in presence of ceritinib	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1391283	Inhibition of EGFR L858R/T790M double mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1424940	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425171	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1815814	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1580126	Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in baculovirus expression system using Tyr 04 as substrate incubated for 1 hr by Z'-LYTE assay
AID1425188	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1703392	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1708233	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1824071	Induction of cell cycle arrest in human NCI-H1975 cells assessed as accumulation at G2/M phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 43.1%)
AID1585919	Inhibition of human N-terminal GST-tagged EGFR T790M/L858R double mutant (695 to end residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate after 60 mins in presence of ATP by ADP-Glo assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1585923	Antiproliferative activity against human A431 cells harboring wild-type EGFR after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1865642	Selectivity ratio of Kinact/Ki for human N-terminal GST-tagged EGFR (669 to 1210 residues) (unknown origin) L858R/T790M mutant to Kinact/Ki for human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) (unknown origin)	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1585934	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 1 uM after 72 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1771693	Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
AID1461713	Selectivity index, ratio of IC50 for wild type EGFR (unknown origin) to IC50 for EGFR L858R/T790M double mutant (unknown origin)	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1484435	Selectivity ratio of IC50 for human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) to IC50 for human recombinant cytoplasmic GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues)	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1740135	Inhibition of wild type EGFR in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1616559	Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
AID1909240	Inhibition of EGFR 19 del/T790M/C797S mutant (unknown origin) by ELISA
AID1583865	Inhibition of EGFR in human DFCI032 cells assessed as reduction in EGFR mediated ERK phosphorylation at 0.1 to 1 uM by Western blot analysis	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1717441	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTT assay
AID1676514	Inhibition of human N-terminal GST-tagged EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 15 mins by HTRF assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1730447	Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system at 0.01 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1865380	Inhibition of wild type EGFR expressed in human A-431 cells	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1484448	Half life in human hepatocytes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1599834	Antiproliferative activity human NCI-H1975 cells incubated for 72 hrs by SRB assay	2019	ACS medicinal chemistry letters, Jun-13, Volume: 10, Issue:6	Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR
AID1865639	Inhibition of recombinant human N-terminal GST-tagged HER2 wild type (679 to 1255 residues) expressed in baculovirus infected Sf9 insect cells assessed as Kinact using AQT0794 as substrate measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1424930	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1391284	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1424923	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425105	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425039	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730527	Cmax in Sprague-Dawley rat assessed as AZ5104 at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1424931	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425107	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481371	Inhibition of EGFR exon 19 deletion mutant in human HCC827 cells assessed as reduction in Akt phosphorylation at Thr308/Ser473 site at 1 uM measured after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425172	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481437	Induction of apoptosis in human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as caspase3 cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1688933	Induction of apoptosis in human HCC827 cells assessed as late apoptotic cells at 1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 18.02%)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1458979	Selectivity ratio of IC50 for wild type N-terminal GST-fused human EGFR cytoplasmic domain to IC50 for human recombinant GST-tagged EGFR L858R/T790M double mutant	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1656714	Inhibition of EGFR L858R/T790M (unknown origin)	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1497685	Induction of apoptosis in human HCC827 cells harboring EGFR E746 to A750 deletion mutant assessed as early apoptotic cells at 3 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.34 to 1.67%)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1740144	Inhibition of wild type EGFR in human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1291334	Inhibition of EGFR Del ex19 mutant phosphorylation in human PC9 cells preincubated for 2 hrs by ELISA	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1708246	Selectivity ratio of IC50 for HLF cells to IC50 for antiproliferative activity against human NCI-H1975 cells	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1425113	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1497686	Induction of apoptosis in human HCC827 cells harboring EGFR E746 to A750 deletion mutant assessed as late apoptotic cells at 3 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 23.66 to 27.14%)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425006	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1880122	Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISA	2022	Journal of medicinal chemistry, 04-28, Volume: 65, Issue:8	The Ascension of Targeted Covalent Inhibitors.
AID1896793	Antiproliferative activity against mouse BaF3 cells expressing EGFR WT assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1425012	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1857184	Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
AID1425070	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167101	Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1445479	Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated for 2 to 90 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1703388	Antiproliferative activity against human A-431 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1740137	Inhibition of TEL-fused EGFR L858R mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1861556	Selectivity ratio IC50 for human NCI-H1299 cells expressing wild type EGFR to human NCI-H1975 cells expressing EGFR L858R/T790M	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1390663	Inhibition of recombinant human full length His-tagged ABL1 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1425167	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1382533	Inhibition of wild type EGFR L858R mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1425094	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709317	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant measured after 72 hrs by celltiter-glo assay	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1861586	Induction of apoptosis in human NCI-H1299 cells assessed as necrotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.24 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1904338	Antiproliferative activity against human HCC827 cells expressing EGFR deletion19 mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1876328	Antiviral activity against SARS-CoV-2 inoculated in african green monkey Vero E6 cells expressing ACE2 assessed as reduction of cytopathic effect measured after 72 hrs by CellTitre-Glo based plate reader method	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.
AID1291353	Clearance in patient with EGFR TKI-resistant NSCLC at 20 to 240 mg, po qd	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1585930	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 0.1 uM after 48 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1424905	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1756966	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1483366	Inhibition of recombinant human N-terminally GST-tagged EGFR L858R/T790M/C797S triple mutant expressed in baculovirus in Sf9 insect cells preincubated for 20 mins followed by addition of [33P]-ATP measured after 2 hrs by filter-binding method	2017	Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11	Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.
AID1585290	Antiproliferative activity against human Calu6 cells harboring WT EGFR after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1585312	Antitumor activity against human HCC827 cells harboring EGFR exon-19 del mutant xenografted in castrated nude mouse assessed as tumor growth inhibition at 10 mg/kg, po daily for 14 consecutive days measured on day 15 relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424889	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730446	Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system at 0.1 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425199	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425054	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585931	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 0.1 uM after 72 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1599833	Antiproliferative activity against mouse BAF3 cells transfected with EGFR L858R/T790M/C797S mutant (unknown origin) incubated for 72 hrs by resazurin dye based assay	2019	ACS medicinal chemistry letters, Jun-13, Volume: 10, Issue:6	Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR
AID1167122	Intrinsic clearance in human hepatocytes measured per 10'6 cells	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425178	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424956	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481348	Inhibition of Tel-fused INSR (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1882661	Inhibition of wildtype EGFR (unknown origin)	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.
AID1865635	Inhibition of recombinant human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells assessed as Kinact/Ki ratio using AQT0734 as substrate measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1771671	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assay
AID1730479	Intrinsic clearance in Beagle dog liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1676530	Inhibition of C-terminal His6-tagged HER2-A775_G776insYVMA mutant (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 40 mins in presence of	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1861574	Induction of apoptosis in human NCI-H1975 cells assessed as early apoptotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.11 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1824058	Induction of cell cycle arrest in human NCI-H1299 cells assessed as accumulation at G0/G1 phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 70.2%)
AID1412320	Selectivity ratio of IC50 for human NCI-H1975 cells to IC50 for human A549 cells
AID1424945	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709334	AUC (0 to 8 hrs) in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1484457	MRT in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1424919	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484455	AUC (0 to 24 hrs) in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1760295	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.
AID1580131	Antiproliferative activity against human NCI-H292 cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1772778	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in phosphorylation of EGFR L858R/T790M mutant at 0.5 to 1 uM incubated for 48 hrs incubated by western blot analysis
AID1425211	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664417	Cell cycle arrest in mouse BAF3 cells harboring EGFR 19D/T790M/C797S mutant assessed as accumulation at S phase at 1 uM measured after 24 hrs by flow cytometry analysis (Rvb = 52.43 %)
AID1617466	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo kinase assay	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
AID1527526	Hepatic clearance in human cryopreserved hepatocytes at 1 uM measured after 240 mins by LC-MS/MS analysis relative to hepatic blood flow	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1425175	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664399	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as reduction in cell viability by CCK8 assay
AID1441914	Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assay	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1616561	Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
AID1484463	MRT in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1481442	Induction of apoptosis in human PC9 cells harboring EGFR exon 19 deletion mutant assessed as PARP cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425016	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424986	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1772745	Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay
AID1425108	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585298	Inhibition of recombinant human N-terminal GST-tagged EGFR (696-end residues) expressed in baculovirus expression system using Srctide as substrate by fluorescence assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1458989	Metabolic stability in human plasma at 5 uM incubated for 1 hr by LC-MS method	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1424988	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1884794	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay
AID1424904	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1824047	Selectivity index, ratio of IC50 for Antiproliferative activity against human A549 cells expressing wild type EGFR to IC50 for antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1390636	Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay
AID1658305	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as reduction in cell viability measured after 72 hrs by WST assay	2020	ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6	Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
AID1425168	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1580135	Cytotoxicity against human BJ cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1481313	Inhibition of Tel-fused EGFR C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425073	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1824045	Antiproliferative activity against human A549 cells expressing wild type EGFR assessed as inhibition in cell viability after 72 hrs by CCK8 assay
AID1425061	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425195	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1688938	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in G2 phase at 1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 8.25 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1412326	Inhibition of EGFR T790M/L858R double mutant in human NCI-H1975 cells assessed as ERK1/2 phosphorylation up to 1000 nM preincubated for 16 hrs followed by EGF stimulation measured after 30 mins by Western blot analysis
AID1585300	Inhibition of EGFR T790M/L858R double mutant phosphorylation at Y1068 residue in human NCI-H1975 cells up to 10 uM after 4 hrs by Western blot analysis	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424968	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709322	In vivo inhibition of EGFR T790M/L858R double mutant in nude mouse xenografted with human NCI-H1975 cells assessed as reduction in AKT phosphorylation at 5 mg, ig measured after 6 hrs by Western blot analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1656712	Antiproliferative activity against human A549 cells measured after 72 hrs by sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1423833	Antiproliferative activity against mouse BAF3 cells harboring EGFR 19D/T790M/C797S mutant after 72 hrs by resazurin dye based assay
AID1583836	Inhibition of wild type GST-tagged human EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1898664	Antiproliferative activity against mouse BaF3 cells expressing wild type EGFR incubated for 72 hrs in absence of cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1585294	Selectivity index, ratio of IC50 for human Calu3 cells harboring WT EGFR to IC50 for human PC9 cells harboring EGFR mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425145	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390632	Inhibition of recombinant human GST-tagged mTOR cytoplasmic domain (1360 to 2549 residues) expressed in baculovirus expression system at 1 uM by LanthaScreen assay relative to control
AID1425088	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1445481	Inhibition of human N-terminal GST-fused EGFR T790M/L858R double mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated for 2 to 90 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1458984	Selectivity ratio of EC50 for human A431 cells expressing wild type EGFR to EC50 for human NCI-H1975 cells harboring EGFR-L858R/T790M double mutant	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1730457	Antiproliferative activity against mouse BaF3 cells harboring EGFR del19/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assay	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1730460	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells at 1 to 1000 nM incubated for 2 hrs followed by EGF stimulation and measured after 15 mins hrs by Western blot analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1389859	Selectivity ratio of IC50 for recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system to IC50 for recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (668 to 1210 re	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1527528	Protein binding in mouse plasma assessed as free fraction after 3 hrs by HPLC-MS/MS-based equilibrium dialysis method	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1425071	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527541	Antitumor activity against human PC9 cells harboring del19/T790M/C797S triple mutant xenografted in BomTac:NMRI-Foxn1nu mouse assessed as tumor growth inhibition at 25 mg/kg, po qd administered for 19 days relative to control	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1898669	Antiproliferative activity against mouse BaF3 cells expressing EGFR Ex19del/T790M/C797S mutant incubated for 72 hrs in absence of cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1425189	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807711	Inhibition of MAP3K9 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1884789	Inhibition of wild type EGFR (unknown origin) by mobility shift assay
AID1688932	Induction of apoptosis in human HCC827 cells assessed as early apoptotic cells at 1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 2.72%)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1424898	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424899	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1824101	Induction of apoptosis in human NCI-H1975 cells assessed as increase in viable cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 94.6%)
AID1585322	Toxicity in castrated nude mouse xenografted with human NCI-H1975 cells assessed as body weight loss at 20 mg/kg, po daily for 14 consecutive days relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1896803	Antiproliferative activity against mouse BaF3 cells expressing Ex20 insertion NPG mutant assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1709318	Cytotoxicity against human A-431 cells harboring wild-type EGFR measured after 72 hrs by celltiter-glo assay	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1365584	Inhibition of wild-type EGFR (unknown origin)	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.
AID1424976	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583869	Inhibition of EGFR in human DFCI032 cells assessed as reduction in EGFR mediated ERK phosphorylation at 0.1 to 1 uM in presence of ceritinib by Western blot analysis	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1807716	Inhibition of PRKCA (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1424935	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807699	Inhibition of EGF-induced phosphorylation of wild type EGFR in human A-431 cells preincubated for 2 hrs followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1772746	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
AID1676513	Inhibition of human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 20 mins by HTRF as	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1481308	Inhibition of EGFR L858R mutant in human H3255 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425014	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425063	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1772780	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in Akt phosphorylation at 0.5 to 1 uM incubated for 48 hrs incubated by western blot analysis
AID1412325	Inhibition of EGFR T790M/L858R double mutant in human NCI-H1975 cells assessed as AKT phosphorylation up to 1000 nM preincubated for 16 hrs followed by EGF stimulation measured after 30 mins by Western blot analysis
AID1424910	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585928	Antiproliferative activity against NHBE cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1861571	Induction of apoptosis in human NCI-H1975 cells assessed as viable cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 96.2 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1481441	Induction of apoptosis in human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as PARP cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1423827	Selectivity ratio of IC50 for inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant to IC50 for inhibition of recombinant human EGFR T790M/L858R double mutant
AID1497672	Antiproliferative activity against human HCC827 cells harboring EGFR E746 to A750 deletion mutant after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425056	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1580125	Inhibition of recombinant human GST-tagged EGFR T790M/L858R mutant expressed in baculovirus expression system using Tyr 04 as substrate incubated for 1 hr by Z'-LYTE assay
AID1599835	Antiproliferative activity human A431 cells incubated for 72 hrs by SRB assay	2019	ACS medicinal chemistry letters, Jun-13, Volume: 10, Issue:6	Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR
AID1760297	Antiproliferative activity against human KG-1 cells incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.
AID1484441	Half life in dog liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1580148	Inhibition of cell migration in human NCI-H1975 cells at 25 nM incubated for 24 hrs by phase contrast microscopy relative to control
AID1656710	Antiproliferative activity against human A431 wild type cells measured after 72 hrs by Sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1585932	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 1 uM after 24 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1688936	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in G2 phase at 0.1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 8.25 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1458987	Apparent permeability across basolateral to apical side in human Caco2 cells at 5 uM incubated for 2 hrs	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1708245	Selectivity ratio of IC50 for human L02 cells to IC50 for antiproliferative activity against human NCI-H1975 cells	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1708238	Inhibition of recombinant human GST-tagged EGFR expressed in baculovirus expression system using tyr-04 peptide as substrate incubated for 60 mins in presence of ATP by Z'-LYTE assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1291345	Drug metabolism in plasma of patient with EGFR TKI-resistant NSCLC assessed as AZ7550 formation at 20 to 240 mg, po qd	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1807706	Inhibition of DYRK1A (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1708239	Selectivity ratio of IC50 for inhibition of recombinant human GST-tagged EGFR expressed in baculovirus expression system to IC50 for inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1167171	Drug metabolism in rat plasma assessed as dealkylation of compound	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1359372	Antiproliferative activity against EGFR T790M/L858R double mutant expressing human NCI-H1975 cells after 72 hrs by SRB assay
AID1425062	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585933	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 1 uM after 48 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1519420	Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 0.462 uM after 24 hrs by AnnexinV-FITC/propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 1.74 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1445480	Inhibition of human N-terminal GST-fused EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin incubated for 2 to 90 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1391285	Antiproliferative activity against human HCC827 cells at 1 uM after 72 hrs by MTT assay relative to control	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1909239	Antiproliferative activity against human osimertinib-resistant PC-9 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
AID1717443	Antiproliferative activity against human A-431 cells incubated for 72 hrs by MTT assay
AID1412318	Cytotoxicity against human NCI-H1975 cells assessed as cell growth inhibition after 4 days by CCK-8 assay
AID1425017	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424998	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519442	Inhibition of EFGR phosphorylation in human HeLa cells at 0.1 to 5 uM after 24 hrs by Western blot analysis	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1519418	Induction of apoptosis in human A549 cells assessed as viable cells at 0.462 uM after 24 hrs by AnnexinV-FITC/propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 94.42 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1425072	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1580139	Selectivity index, ratio of IC50 for human HK2 cells to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1425213	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585283	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1730476	Half life in human liver microsomes assessed as half life preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425203	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1853203	Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cells	2022	RSC medicinal chemistry, Dec-14, Volume: 13, Issue:12	Advanced approaches of developing targeted covalent drugs.
AID1425007	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425192	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865403	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) expressed in mouse BaF3 cells assessed as down streaming of ERK phosphorylation at Thr202/Tyr204 residues	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1424979	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583863	Inhibition of EGFR in human DFCI032 cells assessed as reduction in EGFR phosphorylation at 0.1 to 1 uM by Western blot analysis	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1167157	Antitumor activity against human PC9 cells harboring EGFR exon 19 deletion activating mutant xenografted in SCID mouse assessed as tumor growth inhibition at 5 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1896771	Inhibition of EGFR (unknown origin) d747-752/P7535 mutant assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1424992	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585929	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 0.1 uM after 24 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1298660	Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1872387	Inhibition of cell growth in human Lymphoma cell line bearing EZH2 T790M mutant	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.
AID1709326	Cmax in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1424896	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861554	Antiproliferative activity against human NCI-HCC827 cells expressing EGFR del19 incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1865634	Inhibition of recombinant human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells insect cells using AQT0734 as substrate measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1861582	Induction of apoptosis in human NCI-H1299 cells assessed as early apoptotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.11 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1424894	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1896772	Inhibition of wild type EGFR (unknown origin) preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1382539	Induction of apoptosis in human HCC827 cells harboring EGFR E746-A750 deletion mutant assessed as early apoptotic cells at 3 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.34%)	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1445473	Ratio of Kinact human N-terminal GST-fused EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus to Ki for human N-terminal GST-fused EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1848539	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant assessed as reduction in cell growth incubated for 72 hrs by MTT assay
AID1425021	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1289545	Inhibition of EGF-stimulated wild type EGFR autophosphorylation expressed in human A549 cells by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1658306	Selectivity index, ratio of IC50 for human NCI-H292 cells expressing wild type EGFR assessed as reduction in cell viability measured after 72 hrs by MTT assay to IC50 for human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as reduction in cel	2020	ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6	Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
AID1425038	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1915576	Inhibition of EGFR T790M (unknown origin) incubated for 40 mins in presence of ATP	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.
AID1720096	Inhibition of HDAC (unknown origin)	2020	Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17	Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy.
AID1740138	Inhibition of TEL-fused EGFR T790M/L858R mutant (unknown origin) transfected in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1425027	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1497674	Cytotoxicity against human A549 cells harboring wild type EGFR assessed as reduction in cell viability after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425142	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527527	Hepatic clearance in mouse cryopreserved hepatocytes at 1 uM measured after 240 mins by LC-MS/MS analysis relative to hepatic blood flow	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1167117	Cytotoxicity against human Calu3 cells assessed as growth inhibition after 72 hrs by SYTOX green nucleic acid staining-based fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425009	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425023	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167162	Ratio of free Cave in rat at 200 mg/kg, po as single dose at 24 hrs to IC50 for INSR (unknown origin)	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1664394	Inhibition of wild type EGFR (unknown origin) by ELISA
AID1167166	Cardiotoxicity in anesthetized guinea pig assessed as QT prolongation at fCmax concentration	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1599557	Inhibition of cathepsin C (unknown origin)	2019	Journal of medicinal chemistry, 06-27, Volume: 62, Issue:12	Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors.
AID1865399	Antitumor activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant xenografted in Balb/c nude mouse assessed as in tumor growth inhibition at 20 mg/kg, po administered once daily measured after 14 days	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1425048	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1412317	Inhibition of recombinant human EGFR T790M/L858R double mutant (696 to end residues) using poly(Glu, Tyr) 4 : 1 as substrate after 1 hr by ELISA
AID1519413	Inhibition of wildtype EGFR (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISA	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1861606	Plasma protein binding in rat assessed as unbound fraction at 1 uM incubated for 4 hrs by rapid equilibrium dialysis method	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1425123	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730451	Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1730480	Intrinsic clearance in cynomolgus monkey liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1688939	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in S phase at 1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 41.26 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1676531	Inhibition of C-terminal His6-tagged HER2 (703 to 1029 residues) (unknown origin) expressed in Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins in presence of XL665-labeled streptavi	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1424907	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425077	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424961	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527520	Inhibition of EGFR del19/T790M/C797S triple mutant in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1461709	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by MTS assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1484437	Antiproliferative activity against human HCC827 cells harboring EGFR E746-A750 deletion mutant	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1167172	Drug metabolism in mouse plasma assessed as dealkylation of compound	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1580132	Selectivity index, ratio of IC50 for human NCI-H292 cells expressing EGFR to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1425153	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730450	Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system at 0.01 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425013	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1423831	Inhibition of EGFR 19D/T790M/C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in EGF-induced receptor phosphorylation at 1 to 3 uM preincubated for 2 hrs followed by EGF stimulation for 15 mins by Western blot analysis
AID1709335	AUC (0 to infinity) in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1167108	Thermodynamic solubility of the compound at pH 7.4	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1896801	Antiproliferative activity against mouse BaF3 cells expressing De119/T790M/C797S assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1497691	Inhibition of wild type EGFR (unknown origin)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425030	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807704	Inhibition of CHEK2 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1896773	Inhibition of EGFR (unknown origin) Del19 mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1481311	Growth inhibition of mouse BAF3 cells after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425170	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425207	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865643	Selectivity ratio of Ki for human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) (unknown origin) to Ki for human N-terminal GST-tagged EGFR L858R/T790M mutant (669 to 1210 residues) (unknown origin)	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1583837	Inhibition of GST-tagged human EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1389857	Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition me	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1461706	Solubility of the compound in PBS at pH 7.4	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1730464	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as decrease in ERK activation at 10 nM incubated for 2 followed by compound washout and measured within 12 hrs by Western blot analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1274049	Inhibition of EGFR T790M/deletion (746 to 750 residues) mutant (unknown origin)	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
AID1861580	Induction of apoptosis in human NCI-H1299 cells assessed as viable cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 98.05 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1715791	Inhibition of recombinant human N-terminal GST tagged EGFR L858R mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
AID1425074	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167147	Antitumor activity against human A431 cells xenografted in SCID mouse assessed as tumor growth inhibition at 10 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1909873	Antiproliferative activity against human A-431 cells harboring wild type EGFR measured after 72 hrs by CellTiter-Glo assay	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
AID1167161	Inhibition of INSR (unknown origin)	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1445476	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as growth inhibition after 96 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1708232	Antiproliferative activity against human PC-9 cells harboring EGFR L858R mutant by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1425124	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1771703	Inhibiton of wild type EGFR (unknown origin) assessed as residual enzyme activity using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs at 10XIC50 followed by 100-fold dilution and measured after 30 mins by rapid dilu
AID1664396	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by ELISA
AID1167123	Half life of the compound by GSH reduction assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1424963	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1708243	Cytotoxicity against HLF cells assessed as reduction in cell viability by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1865648	Antiproliferative activity against mouse BAF3 cells harboring HER2 wild type after 72 hrs by resazurin dye-based fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1425082	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730488	Drug metabolism in Sprague-Dawley rat liver microsomes assessed as AZ5104 metabolite levels preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425200	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861579	Induction of apoptosis in human NCI-H1299 cells assessed as viable cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 98.05 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1527532	Antiproliferative activity against human PC9 cells harboring EGFR del19/T790M/C797S triple mutant incubated for 96 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1585926	Antiproliferative activity against human Aspc-1 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1425190	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807705	Inhibition of CSNK1G2 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1688934	Induction of apoptosis in human HCC827 cells assessed as necrotic cells at 1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 7.12 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1861576	Induction of apoptosis in human NCI-H1975 cells assessed as late apoptotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 1.35 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1519432	Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 0.462 uM after 24 hrs by propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 3.45 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1458992	Intrinsic clearance in mouse liver microsomes at 3 uM after 50 mins by LC-MS method	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1807691	Inhibition of EGFR T790M/L858R double mutant (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mins in presence of ATP by IMAP-FP assay	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1497681	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425044	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1676511	Inhibiton of EGFR L858R/T790M mutant (unknown origin) expressed in human NCI-H1975 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1585935	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1880123	Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISA	2022	Journal of medicinal chemistry, 04-28, Volume: 65, Issue:8	The Ascension of Targeted Covalent Inhibitors.
AID1865636	Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) (unknown origin) L858R/T790M mutant expressed in baculovirus infected Sf21 insect cells assessed as Kinact using AQT0734 as substrate measured up to 240 mins by fluorescence	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1709331	Oral bioavailability in rat at 5 mg/kg by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1390633	Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISA
AID1424917	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1321092	Inhibition of EGFR L858R/T790M mutant phosphorylation in human patient derived H1975 cells incubated for 3 hrs by ELISA method	2016	Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14	Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants
AID1580134	Cytotoxicity against human HK2 cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1813865	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M mutant assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Proteome-wide Identification of Off-Targets of a Potent EGFR
AID1896798	Antiproliferative activity against mouse BaF3 cells expressing Del19 assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1865633	Inhibition of recombinant human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) expressed in baculovirus infected Sf21 insect cells assessed as Kinact using AQT0734 as substrate measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1627104	Inhibition of EGF-induced EGFR kinase domain L858R/T790M mutant phosphorylation in human NCI-H1975 cells at 1 to 1000 nM pre-incubated for 2 hrs followed by stimulation with EGF for 15 mins by Western blot method	2016	Journal of medicinal chemistry, 08-11, Volume: 59, Issue:15	Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1617470	Antiproliferative activity against human NCI-H1975 cells harbouring EGFR L858R/T790M/C797S mutant incubated for 72 hrs by MTS assay	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
AID1861577	Induction of apoptosis in human NCI-H1975 cells assessed as necrotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 3.28 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1424966	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585295	Selectivity index, ratio of IC50 for human Calu3 cells harboring WT EGFR to IC50 for human HCC827 cells harboring EGFR mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1815789	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) measured by ELISA	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1616562	Inhibition of GST-tagged human HER2 V777_G778insCG mutant mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
AID1412316	Inhibition of Wild type human EGFR using poly(Glu, Tyr) 4 : 1 as substrate after 1 hr by ELISA
AID1861581	Induction of apoptosis in human NCI-H1299 cells assessed as early apoptotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.11 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1425122	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484461	AUC (0 to infinity) in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1519440	Inhibition of EFGR protein expression in human HeLa cells at 0.1 to 5 uM after 24 hrs by Western blot analysis	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1458982	Antiproliferative activity against human NCI-H1975 cells harboring EGFR-L858R/T790M double mutant incubated for 96 hrs measured on day 5 by CellTiterGlo assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1709321	In vivo inhibition of EGFR T790M/L858R double mutant in nude mouse xenografted with human NCI-H1975 cells assessed as reduction in EGFR phosphorylation at 5 mg, ig measured after 6 hrs by Western blot analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1583840	Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1730489	Drug metabolism in Beagle dog liver microsomes assessed as AZ5104 metabolite levels preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1585284	Antiproliferative activity against human A431 cells harboring WT EGFR after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424951	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390648	Inhibition of human GST-tagged TIE2 cytoplasmic domain expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1424944	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1909244	Antiproliferative activity against mouse BaF3 cells stably expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
AID1458976	Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins followed by ATP and TK-substrate addition measured after 25 mins by HTRF assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1730455	Selectivity ratio of IC50 for antiproliferative activity against human A-431 cells to IC50 for antiproliferative activity against human NCI-H1975 cells	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1807712	Inhibition of MAP4K4 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1445475	Antiproliferative activity against human A431 cells harboring wild type EGFR assessed as growth inhibition after 96 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1565419	Antiproliferative activity against human CL68 cells harbouring EGFR delE746-A750/T790M mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
AID1715789	Inhibition of recombinant human N-terminal GST tagged EGFR L858R/T790M double mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by T	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
AID1291343	Half life in mouse at 25 mg/kg, po	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1824042	Selectivity index, ratio of IC50 Inhibition of wild type EGFR (unknown origin) to IC50 for Inhibition of EGFR T790M/C797S double mutant (unknown origin)
AID1909872	Antiproliferative activity against mouse Ba/F3 cells harbouring Her2-A775_G776insYVMA mutant measured after 72 hrs by CellTiter-Glo assay	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
AID1298662	Selectivity index, ratio IC50 for wild-type EGFR (unknown origin) expressed in baculovirus expression system to IC50 for EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1458993	Intrinsic clearance in human liver microsomes at 3 uM after 50 mins by LC-MS method	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1390653	Inhibition of PI3Kalpha (unknown origin) at 1 uM by fluorescent polarization assay relative to control
AID1676512	Inhibiton of EGFR (unknown origin) expressed in human A431 cells assessed as reduction in EGFR induced cell viability after 96 hrs by CellTiter-Glo assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1425024	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519421	Induction of apoptosis in human A549 cells assessed as necrotic cells at 0.462 uM after 24 hrs by AnnexinV-FITC/propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 0.33 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1390657	Inhibition of recombinant human CDK2 at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1458990	Metabolic stability in mouse plasma at 5 uM incubated for 1 hr by LC-MS method	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1867482	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1424932	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1884795	Antiproliferative activity against human H1975 cells assessed as cell viability after 72 hrs by MTT assay
AID1861585	Induction of apoptosis in human NCI-H1299 cells assessed as necrotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.24 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1580133	Cytotoxicity against human LO2 cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1425111	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390656	Inhibition of recombinant human GST-tagged EPHA2 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1807710	Inhibition of MAP2K1 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1425087	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519430	Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 0.462 uM after 24 hrs by propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 74.31 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1424985	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1740146	Inhibition of wild type EGFR in human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1424978	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1580127	Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system using Tyr 04 as substrate incubated for 1 hr by Z'-LYTE assay
AID1580136	Cytotoxicity against human HLF cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1425186	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865645	Inhibition of EGFR L858R/T790M mutant in human H1975 cells assessed as reduction in autophosphorylation at Y1068 residue at 5 to 50 nM after 2 hrs by Western blot analysis	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1424984	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1389853	Cytotoxicity against human NCI-H1975 cells expressing EGFR L858R/T790M double mutant after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1291344	Drug metabolism in mouse assessed as AUC of AZ5104 at 25 mg/kg, po relative to parent compound	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1167116	Cytotoxicity against human PC9 cells harboring EGFR exon 19 deletion activating mutant assessed as growth inhibition after 72 hrs by SYTOX green nucleic acid staining-based fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425158	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807702	Inhibition of BRSK1 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1425095	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1756998	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs under hypoxic condition by MTT assay	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1709313	Inhibition of recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant using biotinylated TK peptide as substrate measured after 30 mins by HTRF assay	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1423825	Inhibition of recombinant human C-terminal His-tagged/N-terminal GST-tagged EGFR (668 to 1210 residues) T790M/L858R/C797S mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA
AID1771695	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate up to 10 uM preincubated with enzyme for 3 hrs followed by substrate and ATP addition by TR-FRET assay
AID1469777	Inhibition of EGF-stimulated wild type EGFR phosphorylation in human LoVo cells incubated for 2 hrs followed by EGF stimulation for 10 mins by ELISA	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
AID1458978	Inhibition of recombinant human GST-tagged EGFR L858R/T790M double mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and TK-substrate addition measured after 20 mins by HTRF assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1688931	Induction of apoptosis in human HCC827 cells assessed as viable cells at 1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 72.15 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1756965	Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1824040	Inhibition of EGFR T790M/C797S double mutant (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay
AID1824086	Induction of apoptosis in human NCI-H1299 cells assessed as increase in early apoptotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 0.79%)
AID1484440	Half life in rat liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1359371	Antiproliferative activity against wild type EGFR expressing human A431 cells after 72 hrs by SRB assay
AID1824041	Inhibition of wild type EGFR (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay
AID1481443	Induction of apoptosis in human HCC827 cells harboring EGFR exon 19 deletion mutant assessed as PARP cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425121	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1469776	Inhibition of N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (696-end residues) expressed in baculovirus infected Sf21 insect cells	2017	Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3	Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.
AID1298661	Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1425093	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527521	Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1771700	Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by substrate and ATP addition by TR-FRET assay
AID1585304	Antitumor activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant xenografted in castrated nude mouse assessed as tumor growth inhibition at 20 mg/kg, po daily for 14 consecutive days measured on day 15 relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1709329	Half life in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1688909	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in G1 phase at 1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 50.48 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1424937	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481316	Inhibition of Tel-fused EGFR T790M/C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1441907	Inhibition of EGFR delE746_A750 mutant in human HCC827 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assay	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1702617	Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as inhibition of cell growth by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1484475	Inhibition of human ERG expressed in HEK293 cells by lonWorks Quattro analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1359369	Inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISA
AID1425154	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1412327	Glutathione reactivity of the compound assessed as pseudo first order reaction rate constant for GSH adduct formation at 37 degC by LC analysis
AID1167156	Antitumor activity against human NCI-H1975 cells harboring EGFR L858R/T970M double mutant xenografted in SCID mouse assessed as tumor growth inhibition at 5 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425000	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1461711	Inhibition of wild-type EGFR (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1688937	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in S phase at 0.1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 41.26 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1425159	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1824043	Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant assessed as inhibition in cell viability after 72 hrs by CCK-8 assay
AID1896799	Antiproliferative activity against mouse BaF3 cells expressing De119/C797S assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1885367	Antitumor activity against human NCI-H1975 cells xenografted in BALB/c mouse assessed as reduction in tumor volume at 25 mg/kg po qd administered via oral gavage for 14 days	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
AID1904310	Protac activity at VHL/EGFR L858R mutant (unknown origin) assessed as inhibition of EGFR incubated for 40 mins in presence of ATP by Kinase Glo luminescence assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1498608	Inhibition of EGFR L858R/T790M double mutant in EGF-stimulated human NCI-H1975 cells assessed as reduction in Akt phosphorylation at Ser-473 residue at 100 nM by Western blot method	2018	Journal of medicinal chemistry, 07-12, Volume: 61, Issue:13	Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1458986	Apparent permeability across apical to basolateral side in human Caco2 cells at 5 uM incubated for 2 hrs	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1909237	Antiproliferative activity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
AID1434568	Inhibition of N-terminal 6His/TEV protease cleavage site-tagged wild type human EGFR using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR
AID1425049	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1459011	Kinetic solubility in Hepes buffer at 500 uM at pH 7.4 after 90 mins	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1484436	Antiproliferative activity against human A431 cells harboring wild-type EGFR	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1676529	Inhibition of HER2-G776delinsVC mutant (unknown origin) expressed in human H1781 cells assessed as reduction in HER2 induced cell viability after 96 hrs by CellTiter-Glo assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1441930	Ratio of Kinact to Ki for human N-terminal GST-tagged EGFR L858R mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1425129	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484430	Selectivity ratio of IC50 for human NCI-H1975 cells harboring EGFR L858R/T790M double mutant to IC50 for human A431 cells harboring wild-type EGFR	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1867496	Induction of apoptosis in human PC-9 cells expressing EGFR L858R/T790M/C797S mutant assessed as dead cells at 0.25 uM incubated for 24 hrs by annexin-V/propidium iodide staining-based flow cytometry analysis (Rvb = 0.43 %)	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1807694	Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1673934	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)	2020	Journal of medicinal chemistry, 10-08, Volume: 63, Issue:19	Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations.
AID1565416	Antiproliferative activity against wild type human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
AID1904307	Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell proliferation	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1425163	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424997	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1461708	Antiproliferative activity against human PC9 cells harboring EGFR exon 19 deletion mutant after 72 hrs by MTS assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1580140	Selectivity index, ratio of IC50 for human BJ cells to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1425144	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425125	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425003	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425128	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585296	Inhibition of recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant (696-end residues) by fluorescence assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424922	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425141	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527534	Inhibition of EGFR del19 mutant in mouse BAF3 cells incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1481444	Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as PARP cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1484458	Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered via gavage after 24 hrs by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1709323	In vivo inhibition of EGFR T790M/L858R double mutant in nude mouse xenografted with human NCI-H1975 cells assessed as reduction in ERK phosphorylation at 5 mg, ig measured after 6 hrs by Western blot analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1289554	Inhibition of EGFR deletion/T790M mutant autophosphorylation in human PC9-DRH cells after 2 hrs by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1424891	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167175	Antitumor activity against human NCI-H1975 cells harboring EGFR L858R/T970M double mutant xenografted in SCID mouse assessed as tumor growth inhibition at 2.5 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1898671	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R mutant incubated for 72 hrs in presence of 1 ug/ml cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1772779	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in ERK phosphorylation at 0.5 to 1 uM incubated for 48 hrs incubated by western blot analysis
AID1424900	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481349	Inhibition of Tel-fused IGF1R (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1708244	Cytotoxicity against HEK293-A cells assessed as reduction in cell viability by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1481319	Inhibition of full length EGFR T790M/L858R/C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1527525	Aqueous solubility of compound in McIlvaine buffer at 1 mg/ml at pH 6.8 by HPLC-DAD/UV analysis	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1424950	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730551	Elimination half life in Sprague-Dawley rat at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1898668	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M mutant incubated for 72 hrs in absence of cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1425126	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484442	Half life in monkey liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1580130	Antiproliferative activity against human PC9 cells expressing EGFR L858R mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1424911	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167115	Cytotoxicity against human NCI-H1975 cells harboring EGFR L858R/T970M double mutant assessed as growth inhibition after 72 hrs by SYTOX green nucleic acid staining-based fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1239424	Antiproliferative activity against mouse BA/F3 cells expressing TEL-JAK3 after 72 hrs by cell titer glo assay	2015	Journal of medicinal chemistry, Aug-27, Volume: 58, Issue:16	Development of Selective Covalent Janus Kinase 3 Inhibitors.
AID1424999	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424972	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709328	AUC (0 to infinity) in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1481357	Inhibition of wild-type EGFR in human H1355 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425060	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481318	Inhibition of full length EGFR T790M/L858R mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1441941	Reversible inhibition of human N-terminal GST-tagged EGFR L858R mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate assessed as inactivation constant preincubated for 2 to 9	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1824072	Induction of cell cycle arrest in human NCI-H1975 cells assessed as accumulation at S phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 32.7 %)
AID1424929	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1289551	Inhibition of EGFR deletion mutant autophosphorylation in human HCC827 cells after 2 hrs by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1382531	Antiproliferative activity against human A549 cells harboring wild type EGFR after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1390659	Inhibition of recombinant human full length His-tagged AKT1 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1756968	Inhibition of recombinant human N-terminal GST-tagged EGFR T790M mutant (669 to 1210 residues) expressed in baculovirus expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET a	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1425118	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425106	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1708237	Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system using tyrosine 4 peptide as substrate after 60 mins in presence of ATP FRET based Z'-LYTE assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1585297	Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in baculovirus expression system by fluorescence assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424927	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1458980	Antiproliferative activity against human A431 cells expressing wild type EGFR incubated for 96 hrs measured on day 5 by CellTiterGlo assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1445477	Inhibition of human EGFR T790M/C797S/L858R triple mutant preincubated for 20 mins followed by [33P]ATP addition measured after 2 hrs	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1585292	Selectivity index, ratio of IC50 for human A431 cells harboring WT EGFR to IC50 for human PC9 cells harboring EGFR mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1390658	Inhibition of recombinant human full length His-tagged PIM1 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1289550	Inhibition of EGFR deletion mutant autophosphorylation in human PC9 cells after 2 hrs by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1484453	Tmax in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1656713	Cytotoxicity against human HL7702 cells measured after 72 hrs by sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1527529	Protein binding in human plasma assessed as free fraction after 3 hrs by HPLC-MS/MS-based equilibrium dialysis method	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1445472	Ratio of Kinact for human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus to Ki for human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1484439	Half life in mouse liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1425147	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424970	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865641	Inhibition of recombinant human N-terminal GST-tagged HER2 wild type (679 to 1255 residues) expressed in baculovirus infected Sf9 insect cells assessed as Kinact/Ki ratio using AQT0794 measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1481354	Inhibition of EGFR exon 19 deletion mutant in human HCC827 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1274037	Inhibition of EGFR T790M/L858R mutant (unknown origin)	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
AID1909245	Cytotoxicity against mouse IL-3 dependent BaF3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
AID1884792	Selectivity index, ratio of IC50 for wild-type EGFR (unknown origin) to IC50 for EGFR L858R/T790M/C797S mutant (unknown origin)
AID1896800	Antiproliferative activity against mouse BaF3 cells expressing De119/T790M assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1425104	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730487	Drug metabolism in CD1 mouse liver microsomes assessed as AZ5104 metabolite levels preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425164	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424210	Antitumor activity against human NCI-H1975 cells xenografted in STOCK-Foxn1nu/Nju nude mouse assessed as inhibition of tumor growth at 20 mg/kg/day, po qd for 14 days relative to untreated control	2017	European journal of medicinal chemistry, Jun-16, Volume: 133	Synthesis and biological evaluation of morpholine-substituted diphenylpyrimidine derivatives (Mor-DPPYs) as potent EGFR T790M inhibitors with improved activity toward the gefitinib-resistant non-small cell lung cancers (NSCLC).
AID1390638	Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISA
AID1730473	Half life in Sprague-Dawley rat liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 20 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1585293	Selectivity index, ratio of IC50 for human A431 cells harboring WT EGFR to IC50 for human HCC827 cells harboring EGFR mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425036	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1359368	Inhibition of recombinant human GST-tagged wild type EGFR expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 1 hr by ELISA
AID1425084	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484452	Half life in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1824104	Induction of apoptosis in human NCI-H1975 cells assessed as increase in necrotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 0.35%)
AID1425156	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1458977	Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and TK-substrate addition measured after 15 mins by HTRF assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1915575	Inhibition of EGFR wildtype (unknown origin) incubated for 40 mins in presence of ATP	2021	European journal of medicinal chemistry, Jan-01, Volume: 209	Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.
AID1167146	Antitumor activity against human PC9 cells harboring EGFR exon 19 deletion activating mutant xenografted in SCID mouse assessed as tumor growth inhibition at 10 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1857186	Antiproliferative activity against human NCI-H1975 cells harbouring Akt3 T305A/S472A mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
AID1390662	Inhibition of recombinant human GST-tagged JAK1 cytoplasmic domain expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1425029	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1289546	Inhibition of EGFR L858R/T790M double mutant autophosphorylation in human NCI-H1975 cells after 2 hrs by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1424989	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1815788	Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured by ELISA	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1688913	Antiproliferative activity against human A-431 cells harboring EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1704924	Antiproliferative activity against human HCC827 cells expressing EGFR del19 mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Discovery of potent small molecule PROTACs targeting mutant EGFR.
AID1425099	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1289547	Selectivity ratio of IC50 for EGF-stimulated wild type EGFR in human A549 cells to IC50 for EGFR L858R/T790M double mutant in human NCI-H1975 cells	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1857185	Antiproliferative activity against human NCI-H1975 cells harbouring wild type Akt3 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
AID1289555	Inhibition of EGFR L858R mutant autophosphorylation in human H3255 cells after 2 hrs by sandwich ELISA	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1760296	Antiproliferative activity against human MDA-MB-468 cells incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.
AID1656709	Antiproliferative activity against human H1975-1 harboring EGFR L858R/T790M mutant measured after 72 hrs by sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1424924	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424948	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484431	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1709314	Inhibition of wild-type EGFR (unknown origin) using biotinylated TK peptide as substrate measured after 30 mins by HTRF assay	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1390660	Inhibition of recombinant human full length GST-tagged SYK expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1896775	Inhibition of EGFR (unknown origin) L858R/T790M mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1497693	Inhibition of EGFR L858R/T790M double mutant (unknown origin)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1389854	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1738670	Inhibition of N-terminal GST-fused human EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate incubated for 20 mins by Mobility shift assay	2020	European journal of medicinal chemistry, Aug-01, Volume: 199	Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFR
AID1824060	Induction of cell cycle arrest in human NCI-H1299 cells assessed as accumulation at S phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 24.8%)
AID1424915	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807713	Inhibition of MAPK3 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1425191	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484450	Intrinsic clearance in human hepatocytes assessed per million cells	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1824044	Antiproliferative activity against human HCC827 cells expressing EGFR del119 mutant assessed as inhibition in cell viability after 72 hrs by CCK8 assay
AID1425160	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585288	Selectivity index, ratio of IC50 for human A431 cells harboring WT EGFR to IC50 for human NCI-H1975 cells harboring EGFR T790M/L858R double mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1885396	Antitumor activity against mouse Ba/F3 EGFR-Del19/T790M/C797S cells implanted in NOD SCID mouse assessed as reduction in tumor volume at 25 mg/kg, po qd administered via oral gavage for 14 days	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
AID1423824	Inhibition of recombinant human EGFR T790M/L858R double mutant using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA
AID1815816	Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1425002	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583842	Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1424890	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481370	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in P70S6K phosphorylation at Thr389 site at 1 uM measured after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1424926	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1580129	Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1424980	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424975	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481372	Inhibition of EGFR exon 19 deletion mutant in human HCC827 cells assessed as reduction in P70S6K phosphorylation at Thr389 site at 1 uM measured after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1709341	Drug metabolism in rat assessed as N-(4-methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide formation at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1382529	Antiproliferative activity against human HCC827 cells harboring EGFR E746-A750 deletion mutant after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1481317	Inhibition of full length EGFR exon 19 deletion mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1848537	Inhibition of N-terminal GST-tagged human recombinant wild type EGFR (695 to end residues) expressed in baculovirus-infected Sf9 cells using poly (4:1 Glu,Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assay
AID1424902	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807697	Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 2 hrs followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1909871	Antiproliferative activity against mouse Ba/F3 EGFR-H773-V774ins_NPH cells measured after 72 hrs by CellTiter-Glo assay	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
AID1390651	Inhibition of recombinant human GST-tagged EPHB2 cytoplasmic domain (616 to 884 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1585299	Selectivity index, ratio of IC50 for recombinant human N-terminal GST-tagged EGFR (696-end residues) expressed in baculovirus expression system to IC50 for recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant (696-end residues)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425174	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807709	Inhibition of IGF1R (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1425131	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1703395	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as inhibition of cell viability measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1704926	Antiproliferative activity against human HepG2 cells expressing VEGFR2 assessed as cell growth inhibition measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Discovery of potent small molecule PROTACs targeting mutant EGFR.
AID1461707	Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTS assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1898673	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant incubated for 72 hrs in presence of 1 ug/ml cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1730452	Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425138	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1896797	Antiproliferative activity against mouse BaF3 cells expressing L858R/T790M/C797S assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1481353	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1167176	Antitumor activity against human A431 cells xenografted in SCID mouse assessed as tumor growth inhibition at 2.5 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1807693	Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1730477	Intrinsic clearance in CD1 mouse liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1390645	Inhibition of recombinant human His-tagged KIT cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1441938	Reversible inhibition of human N-terminal GST-tagged EGFR L858R mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated for 2 to 90 mins followed by 6-fold dilution	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1580141	Selectivity index, ratio of IC50 for human HLF cells to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1717440	Antiproliferative activity against human HCC827 cells incubated for 72 hrs by MTT assay
AID1298671	Antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant after 72 hrs by SRB assay	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1424983	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167169	Drug metabolism in rat plasma assessed as loss of indole N-methyl group	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425133	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1815231	Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1865364	Inhibition of EGFR L858R/T790M/C797S mutant (unkown origin) expressed in mouse BaF3 cells assessed as phosphorylation at Tyr1068 residue	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1425134	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425130	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424959	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730472	Half life in CD1 mouse liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1815232	Inhibition of wild type EGFR (unknown origin) measured by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1389856	Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition measured after 1 hr by mobil	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1688910	Antiproliferative activity against human HCC827 cells harboring EGFRDel19 mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1359373	Selectivity index, ratio of IC50 for EGFR T790M/L858R double mutant expressing human NCI-H1975 cells to IC50 for wild type EGFR expressing human A431 cells
AID1424962	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1607091	In vivo inhibition of EFGR T790M mutant in human NCI-H1975 cells xenografted in NCr nude mouse assessed as reduction of EGFR phosphorylation at Y1173 residue 2.5 mg/kg measured up to 24 hrs relative to control	2020	Journal of medicinal chemistry, 05-14, Volume: 63, Issue:9	Discovery of (2
AID1365586	Inhibition of EGFR L858R/T790M mutant (unknown origin)	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.
AID1425204	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1880130	Inhibition of EGFR phosphorylation (unknown origin)	2022	Journal of medicinal chemistry, 04-28, Volume: 65, Issue:8	The Ascension of Targeted Covalent Inhibitors.
AID1585920	Inhibition of wild-type human N-terminal GST-tagged EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using Poly (4:1 Glu, Tyr) as substrate after 60 mins in presence of ATP by ADP-Glo assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1861583	Induction of apoptosis in human NCI-H1299 cells assessed as late apoptotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 1.53 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1872409	Inhibition of KDM1A (unknown origin)	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present).
AID1815233	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) measured by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1709315	Selectivity ratio of IC50 for inhibition of wild-type EGFR (unknown origin) to IC50 for inhibition of recombinant human N-terminal GST-tagged EGFR T790M/L858R double mutant	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1688935	Induction of cell cycle arrest in human HCC827 cells assessed as accumulation in G1 phase at 0.1 uM incubated for 32 hrs by PI staining based flow cytometry analysis (Rvb = 50.48 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1730475	Half life in cynomolgus monkey liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425206	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425176	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1389858	Inhibition of recombinant human GST-tagged EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using FAM-labelled peptide as substrate pretreated for 10 mins followed by substrate addition measured after	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1815819	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell proliferation measured after 72 hrs by SRB assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1424908	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1772747	Cytotoxicity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
AID1425096	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1391281	Inhibition of wild type EGFR (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1425083	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1321094	Inhibition of EGFR E746 to A750 deletion mutant phosphorylation in human patient derived HCC827 cells incubated for 3 hrs by ELISA method	2016	Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14	Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants
AID1896770	Inhibition of EGFR (unknown origin) Del19 mutant assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1824070	Induction of cell cycle arrest in human NCI-H1975 cells assessed as accumulation at G0/G1 phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 24.2%)
AID1425161	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519415	Selectivity ratio of IC50 for wildtype EGFR (unknown origin) to IC50 for EGFR T790M/L858R double mutant (unknown origin) by mobility shift assay based ELISA	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1880133	Inhibition of wild-type HER2 phosphorylation in human BT-474 cells	2022	Journal of medicinal chemistry, 04-28, Volume: 65, Issue:8	The Ascension of Targeted Covalent Inhibitors.
AID1167103	Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425183	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865640	Inhibition of recombinant human N-terminal GST-tagged HER2 wild type (679 to 1255 residues) expressed in baculovirus infected Sf9 insect cells using AQT0794 measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1425109	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664395	Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISA
AID1425053	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664400	Antiproliferative activity against mouse BAF3 cells harboring EGFR 19D/T790M/C797S mutant assessed as reduction in cell viability by CCK8 assay
AID1390640	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant after 72 hrs by MTT assay
AID1441911	Inhibition of human N-terminal GST-tagged EGFR L858R mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated with enzyme for 30 mins followed by substrate addition	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1708234	Antiproliferative activity against human NCI-H292 cells harboring wild-type EGFR by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1425050	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1391282	Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1441912	Inhibition of human N-terminal GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated with enzyme for 30 mins followed by substr	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1756967	Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET assay	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1481351	Inhibition of EGFR T790M/L858R mutant (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1688927	Induction of apoptosis in human HCC827 cells assessed as viable cells at 0.1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 76.79 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1497692	Inhibition of EGFR L858R mutant (unknown origin)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1382540	Induction of apoptosis in human HCC827 cells harboring EGFR E746-A750 deletion mutant assessed as late apoptotic cells at 3 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 27.14%)	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1390647	Inhibition of recombinant human His-tagged PDGFRbeta cytoplasmic domain (558 to 1106 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1909243	Inhibition of wild type EGFR (unknown origin) by ELISA
AID1425117	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1824046	Antiproliferative activity against human NCI-H1299 cells expressing wild type EGFR assessed as inhibition in cell viability after 72 hrs by CCK8 assay
AID1896796	Antiproliferative activity against mouse BaF3 cells expressing L858R/T790M assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1425162	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425116	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425140	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1702616	Inhibition of human EGFR cytoplasmic domain L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf21 cells using biotin-labeled TK substrate preincubated for 30 mins followed by substrate and ATP addition at Km concentration and fu	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1423832	Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M/C797S mutant after 72 hrs by resazurin dye based assay
AID1585301	Inhibition of EGFR T790M/L858R double mutant in human NCI-H1975 cells assessed as reduction in ERK phosphorylation at T202/Y204 residues up to 10 uM after 4 hrs by Western blot analysis	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425127	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167165	Toxicity in rat assessed as hyperglycemia at 200 mg/kg, po as single dose measured over 24 hrs	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1445470	Inhibition of human N-terminal GST-fused EGFR T790M/L858R double mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 30 mins followed by substrate addition measured after 20 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1824039	Inhibition of EGFR del19 (unknown origin) using flurogenic substrate in presence of ATP by HTRF assay
AID1580144	Cytotoxicity against human HK2 cells assessed as change in cell morphology at 5 and 10 uM incubated for 48 hrs by microscopic analysis
AID1424933	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1872386	Inhibition of cell growth in human multiple BC cells bearing wildtype EZH2	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.
AID1291352	Apparent half life in patient with EGFR TKI-resistant NSCLC at 20 to 240 mg, po qd	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1441910	Inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated with enzyme for 30 mins followed by substrate addition mea	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1425045	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861553	Antiproliferative activity against human NCI-H1299 cells expressing wild type EGFR incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1425182	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861575	Induction of apoptosis in human NCI-H1975 cells assessed as late apoptotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 1.35 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1425004	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1627105	Inhibition of EGF-induced EGFR kinase domain L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in ERK phosphorylation at 1 to 1000 nM pre-incubated for 2 hrs followed by stimulation with EGF for 15 mins by Western blot method	2016	Journal of medicinal chemistry, 08-11, Volume: 59, Issue:15	Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1882660	Inhibition of EGFR T790M/L858R double mutant (unknown origin)	2022	Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7	Development of Dual Inhibitors Targeting Epidermal Growth Factor Receptor in Cancer Therapy.
AID1425019	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390661	Inhibition of recombinant human full length His-tagged MEK1 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1445468	Inhibition of human N-terminal GST-fused EGFR L858R mutant (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 30 mins followed by substrate addition measured after 15 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1730448	Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system at 1 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425193	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1815787	Inhibition of wild type EGFR (unknown origin) measured by ELISA	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1617469	Antiproliferative activity against human NCI-H1975 cells incubated for 72 hrs by MTS assay	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
AID1167148	Clearance in iv dosed Han Wistar rat	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1583844	Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1481314	Inhibition of Tel-fused EGFR L858R mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1658307	Antiproliferative activity against human NCI-H292 cells expressing wild type EGFR assessed as reduction in cell viability measured after 72 hrs by WST assay	2020	ACS medicinal chemistry letters, Jun-11, Volume: 11, Issue:6	Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
AID1423834	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M mutant after 72 hrs by resazurin dye based assay
AID1585936	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 10 uM after 48 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1425097	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1904337	Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1884793	Inhibition of c-Met (unknown origin) by mobility shift assay
AID1884788	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) at 300 nM by mobility shift assay
AID1898667	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R mutant incubated for 72 hrs in absence of cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1412319	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 4 days by CCK-8 assay
AID1441913	Inhibition of wild-type EGFR in human A431 cells assessed as reduction in cell viability after 96 hrs by CellTiterGlo assay	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1656711	Antiproliferative activity against human HCC827 cells measured after 72 hrs by sulforhodamine B assay	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1484462	Clearance in Sprague-Dawley rat at 1 mg/kg, iv after 24 hrs by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1887652	Antiproliferative against in mouse Ba/F3 EGFR-T790M/C797S/L858R cells	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
AID1424987	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425078	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425022	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1441929	Ratio of Kinact to Ki for reversible inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1425081	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861584	Induction of apoptosis in human NCI-H1299 cells assessed as late apoptotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 1.53 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1423830	Inhibition of EGFR T790M/L858R/C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in EGF-induced receptor phosphorylation at 1 to 3 uM preincubated for 2 hrs followed by EGF stimulation for 15 mins by Western blot analysis
AID1424981	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865637	Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) (unknown origin) L858R/T790M mutant expressed in baculovirus infected Sf21 insect cells using AQT0734 as substrate measured up to 240 mins by fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1884791	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by mobility shift assay
AID1298672	Selectivity ratio, ratio IC50 for human A431 cells overexpressing wild-type EGFR to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1580138	Selectivity index, ratio of IC50 for human LO2 cells to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1709319	Selectivity ratio of IC50 for human A-431 cells harboring wild-type EGFR to IC50 for human NCI-H1975 cells harboring EGFR L858R/T790M double mutant	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1481312	Inhibition of Tel-fused EGFR (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1424958	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424909	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484444	Intrinsic clearance in mouse liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1481356	Inhibition of wild-type EGFR in human NCI-H2122 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1702620	Antiproliferative activity against human U87MG Human EGFR vIII cells overexpressing EGFRvIII mutant assessed as inhibition of cell growth by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1904339	Antiproliferative activity against human A-431 cells expressing EGFR wildtype assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1664418	Cell cycle arrest in mouse BAF3 cells harboring EGFR 19D/T790M/C797S mutant assessed as accumulation at G2 phase at 1 uM measured after 24 hrs by flow cytometry analysis (Rvb = 7.94 %)
AID1815229	Cytotoxicity against human A-431 cells assessed as reduction in cell viability measured by MTT assay	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1390652	Inhibition of recombinant truncated human His-tagged MET expressed in mammalian expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1412324	Inhibition of EGFR T790M/L858R double mutant phosphorylation in human NCI-H1975 cells up to 1000 nM preincubated for 16 hrs followed by EGF stimulation measured after 30 mins by Western blot analysis
AID1730478	Intrinsic clearance in Sprague-Dawley rat liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1730453	Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1612546	Inhibition of EGFR T790M/L858R double mutant (unknown origin) using substrate-biotin by ELISA-based mobility shift assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1885395	Antitumor activity against mouse Ba/F3 EGFR-T790M/C797S/L858R cells implanted in NOD SCID mouse assessed as reduction in tumor volume at 25 mg/kg, po qd administered via oral gavage for 14 days	2022	Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14	Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
AID1321093	Inhibition of EGFR L858R mutant phosphorylation in human patient derived H3255 cells incubated for 3 hrs by ELISA method	2016	Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14	Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants
AID1382534	Inhibition of wild type EGFR L858R/T790M double mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1815815	Antiproliferative activity against mouse BaF3 cells expressing EGFR 19Del/T790M/C797S triple mutant assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1390635	Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay
AID1484460	AUC (0 to 24 hrs) in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1740145	Inhibition of wild type EGFR in human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1424901	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167145	Antitumor activity against human NCI-H1975 cells harboring EGFR L858R/T970M double mutant xenografted in SCID mouse assessed as tumor growth inhibition at 10 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1691144	Induction of EGFR degradation in human A431 cells by Western blot analysis	2020	European journal of medicinal chemistry, Apr-15, Volume: 192	Design and synthesis of selective degraders of EGFR
AID1434571	Antiproliferative activity against human A431 cells harboring wild type EGFR after 72 hrs by SRB assay	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR
AID1585922	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1424928	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1762240	Inhibition of EGFR (unknown origin)	2021	Bioorganic & medicinal chemistry letters, 06-01, Volume: 41	Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines.
AID1425179	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425149	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167119	Unbound fraction in human plasma	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1424918	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425091	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1815818	Antiproliferative activity against human PC-9 cells expressing EGFR 19Del/T790M/C797S triple mutation assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1730470	Toxicity in Balb/c nude mouse xenografted with human NCI-H1975 cells harboring EGFR L858R/T790M mutant assessed as change in body weight at 1.5 to 2.5 mg/kg, po QD administered via gavage for 24 days and measured twice weekly	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1717442	Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
AID1425092	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1291335	Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs by ELISA	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1580137	Cytotoxicity against human HEK293A cells expressing EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1583841	Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1580128	Selectivity index, ratio of IC50 for recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system to IC50 for recombinant human GST-tagged EGFR T790M/L858R expressed in baculovirus expression system
AID1390646	Inhibition of recombinant human His-tagged FGFR1 cytoplasmic domain (308 to 731 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1756964	Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2021	European journal of medicinal chemistry, Apr-15, Volume: 216	Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors.
AID1425169	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390650	Inhibition of recombinant human full length His-tagged aurora A expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1715790	Inhibition of recombinant human N-terminal GST tagged EGFR d746-750 mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET ass	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Novel quinazoline derivatives bearing various 6-benzamide moieties as highly selective and potent EGFR inhibitors.
AID1771702	Ratio of IC50 for inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr to IC50 for inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate
AID1861552	Antiproliferative activity against human A549 cells expressing wild type EGFR incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1730449	Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system at 0.1 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1412328	Stability in fetal bovine serum assessed as pseudo first order reaction rate constant
AID1425080	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481358	Inhibition of wild-type EGFR in human H1703 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1709337	MRT (0 to infinity) in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1497673	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1585308	Antitumor activity against human PC9 cells harboring EGFR exon-19 del mutant xenografted in castrated nude mouse assessed as tumor growth inhibition at 10 mg/kg, po daily for 14 consecutive days measured on day 15 relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424934	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425143	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1527530	Apparent permeability of compound at pH 7.4 by LC-MS based PAMPA method	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1425035	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1612548	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1887631	Antiproliferative against in mouse Ba/F3 EGFR-Del19/T790M/C797S cells	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer.
AID1424947	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585924	Selectivity index, ratio of IC50 for human A431 cells harboring wild-type EGFR to IC50 for human NCI-H1975 cells harboring EGFR T790M/L858R double mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1425198	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1289556	Selectivity ratio of IC50 for EGF-stimulated wild type EGFR in human A549 cells to IC50 for EGFR deletion mutant in human PC9 cells	2016	Journal of medicinal chemistry, Mar-10, Volume: 59, Issue:5	Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
AID1481359	Growth inhibition of CHO cells after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1583870	Inhibition of EGFR in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1896804	Antiproliferative activity against mouse BaF3 cells expressing Ex20 insertion GV mutant assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1824087	Induction of apoptosis in human NCI-H1299 cells assessed as increase in late apoptotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 4.39%)
AID1807708	Inhibition of GSK3B (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1481355	Inhibition of wild-type EGFR in human A549 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1691145	Induction of EGFR L858R/T790M mutant degradation in human NCI-H1975 cells by Western blot analysis	2020	European journal of medicinal chemistry, Apr-15, Volume: 192	Design and synthesis of selective degraders of EGFR
AID1424994	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484451	Intrinsic clearance in rat hepatocytes assessed per million cells	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1708242	Cytotoxicity against HK-2 cells assessed as reduction in cell viability by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1703386	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1583867	Inhibition of EGFR in human DFCI032 cells assessed as reduction in EGFR phosphorylation at 0.1 to 1 uM in presence of ceritinib by Western blot analysis	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1425181	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1676528	Inhibition of HER2-A775_G776insYVMA mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in HER2 induced cell viability after 96 hrs by CellTiter-Glo assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1664402	Selectivity index, ratio of IC50 for human A431 cells overexpressing EGFR assessed as reduction in cell viability by CCK8 assay to IC50 for mouse BAF3 cells harboring EGFR 19D/T790M/C797S assessed as reduction in cell viability by CCK8 assay
AID1291336	Inhibition of wild type EGFR phosphorylation in human LoVo cells preincubated for 2 hrs followed by EGF stimulation measured after 30 mins by ELISA	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1291346	Drug metabolism in plasma of patient with EGFR TKI-resistant NSCLC assessed as AZ5104 formation at 20 to 240 mg, po qd	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1865404	Inhibition of EGFR L858R/C797S mutant (unknown origin) expressed in mouse BaF3 cells assessed as down streaming of ERK phosphorylation at Thr202/Tyr204 residues	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1497679	Inhibition of EGFR L858R mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1702613	Inhibition of wild type N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus infected Sf21 cells at 1 uM using biotin-labeled TK substrate preincubated for 30 mins followed by substrate and ATP addition at Km	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1425034	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425046	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484449	Half life in rat hepatocytes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1898662	Inhibition of human EGFR L858R/T790M/C797S mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1909238	Antiproliferative activity against mouse BaF3 cells harboring EGFR 19 del/T790M/C797S mutant assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
AID1867481	Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1865638	Inhibition of recombinant human N-terminal GST-tagged EGFR (669 to 1210 residues) (unknown origin) L858R/T790M mutant expressed in baculovirus infected Sf21 insect cells assessed as Kinact/Ki ratio using AQT0734 as substrate measured up to 240 mins by flu	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1390634	Inhibition of recombinant truncated human His-tagged IGF1R expressed in mammalian expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1481440	Induction of apoptosis in human H3255 cells harboring EGFR L858R mutant assessed as caspase-3 cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1730552	AUC (0 to 24 hrs) in Sprague-Dawley rat at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1865647	Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R mutant after 72 hrs by resazurin dye-based fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1740147	Inhibition of wild type EGFR in human A-431 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1424941	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585286	Antiproliferative activity against human PC9 cells harboring EGFR mutant after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1424964	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583843	Antiproliferative activity against mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1382530	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant after 72 hrs by MTT assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1730445	Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system at 1 uM using poly (Glu-Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425208	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730528	Tmax in Sprague-Dawley rat assessed as AZ5104 at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1390654	Inhibition of recombinant human His-tagged KDR cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1824059	Induction of cell cycle arrest in human NCI-H1299 cells assessed as accumulation at G2/M phase at 2.5 uM after 36 hrs by PI staining based flow cytometry analysis (Rvb = 5.6%)
AID1565420	Antiproliferative activity against human CL97 cells harbouring EGFR G719A/T790M mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
AID1425079	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1771675	Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate incubated for 1 hr by TR-FRET assay
AID1809473	Inhibition of EGFR Exon19Del/C797S double mutant (unknown origin) by biochemical assay	2021	Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18	Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
AID1580143	Cytotoxicity against human LO2 cells assessed as change in cell morphology at 5 and 10 uM incubated for 48 hrs by microscopic analysis
AID1688912	Antiproliferative activity against human A549 cells harboring EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1391278	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1580145	Cytotoxicity against human HEK293A cells assessed as change in cell morphology at 5 and 10 uM incubated for 48 hrs by microscopic analysis
AID1484434	Inhibition of human recombinant cytoplasmic GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET-based Z'	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1481438	Induction of apoptosis in human PC9 cells harboring EGFR exon 19 deletion mutant assessed as caspase-3 cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1896802	Antiproliferative activity against mouse BaF3 cells expressing Ex20 insertion SVD mutant assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1865365	Inhibition of EGFR L858R/C797S mutant (unkown origin) expressed in mouse BaF3 cells assessed as phosphorylation at Tyr1068 residue	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1484438	Half life in human liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1583845	Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1167130	Cmax in mouse at 10 mg/kg, po	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425187	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424993	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167110	Inhibition of IGF1R (unknown origin)	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1815248	Selectivity ratio of IC50 for EGFR L858R/T790M double mutant (unknown origin) to IC50 for wildtype EGFR (unknown origin) measured by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1423835	Antiproliferative activity against human A431 cells harboring wild type EGFR after 72 hrs by resazurin dye based assay
AID1365587	Inhibition of EGFR exon 19 deletion mutant (unknown origin)	2017	Bioorganic & medicinal chemistry letters, 11-01, Volume: 27, Issue:21	Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.
AID1909241	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by ELISA
AID1599837	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) transfected in mouse BAF3 cells assessed as inhibition of EGF-induced EGFR phosphorylation at 1 uM by Western blot analysis relative to control	2019	ACS medicinal chemistry letters, Jun-13, Volume: 10, Issue:6	Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR
AID1617467	Inhibition of C-terminal His-tagged/ N-terminal GST-tagged recombinant human EGFR L858R/T790M double mutant (668 to 1210 residues) expressed in a Baculovirus infected Sf9 cell expression system using poly-EY as substrate incubated for 30 mins by ADP-Glo k	2019	Journal of natural products, 11-22, Volume: 82, Issue:11	Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
AID1481350	Inhibition of wild-type EGFR (unknown origin) autophosphorylation at Y1068 expressed in mouse BAF3 cells after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1583851	Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs in presence of ceritinib by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1425166	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484433	Inhibition of human recombinant cytoplasmic GST-tagged EGFR L858R mutant expressed in baculovirus using TK-substrate-biotin preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET-based Z'-Lyte assay	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1861572	Induction of apoptosis in human NCI-H1975 cells assessed as viable cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 96.2 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1861573	Induction of apoptosis in human NCI-H1975 cells assessed as early apoptotic cells at 0.1 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 0.11 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1497680	Inhibition of EGFR L858R/T790M double mutant (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1867480	Antiproliferative activity against human PC-9 cells expressing EGFR L858R/T790M/C797S mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1709325	Tmax in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1390649	Inhibition of recombinant human full length untagged PKCalpha expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1824103	Induction of apoptosis in human NCI-H1975 cells assessed as increase in late apoptotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 3.85%)
AID1321095	Inhibition of wild type EGFR phosphorylation in human HaCaT cells incubated for 3 hrs by ELISA method	2016	Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14	Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants
AID1708247	Selectivity ratio of IC50 for HEK293-A cells to IC50 for antiproliferative activity against human NCI-H1975 cells	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1527533	Antiproliferative activity against human A431 cells harboring EGFR wild type incubated for 96 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1389855	Selectivity ratio of IC50 for human A549 cells expressing wild-type EGFR/K-Ras mutant to IC50 for human NCI-H1975 cells expressing EGFR L858R/T790M double mutant	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1580142	Selectivity index, ratio of IC50 for human HEK293A cells to IC50 for human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1167158	Antitumor activity against human A431 cells xenografted in SCID mouse assessed as tumor growth inhibition at 5 mg/kg/day, po qd for 7 days relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1676515	Inhibition of human N-terminal GST-tagged EGFR (669 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using TK as substrate preincubated for 30 mins followed by substrate addition and measured after 25 mins by HTRF assay	2020	Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20	Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
AID1167155	AUC in mouse at 10 mg/kg, po	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425047	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481315	Inhibition of Tel-fused EGFR L858R/C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1589887	Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assay	2019	Bioorganic & medicinal chemistry letters, 06-15, Volume: 29, Issue:12	Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors.
AID1688911	Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858/T790M mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1585921	Selectivity index, ratio of IC50 for wild-type human N-terminal GST-tagged EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells to IC50 for human N-terminal GST-tagged EGFR T790M/L858R double mutant (695 to end residues) expressed	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1848540	Cytotoxicity against human A-431 cells harboring wild type EGFR assessed as reduction in cell viability incubated for 72 hrs by MTT assay
AID1424965	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424949	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730474	Half life in Beagle dog liver microsomes preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1425090	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664416	Cell cycle arrest in mouse BAF3 cells harboring EGFR 19D/T790M/C797S mutant assessed as accumulation at G1 phase at 1 uM measured after 24 hrs by flow cytometry analysis (Rvb = 39.62 %)
AID1585937	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as cell viability at 10 uM after 72 hrs by MTT assay (Rvb = 98.3%)	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1867479	Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1425042	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425098	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1708298	Antitumor activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant xenografted in nude mouse assessed as tumor volume at 15 mg/kg, po administered once daily for 7 days (Rvb = 843 mm3)	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1703389	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1815226	Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured at 0.1 uM by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1896774	Inhibition of EGFR (unknown origin) L858R mutant preincubated with compound 30 mins followed ATP addition incubated for 30 mins by HTRF KinEASE TK assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1484443	Intrinsic clearance in human liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1607086	Antitumor activity against human NCI-H1975 cells harboring EGFR T790M mutant xenografted in NCr nude mouse assessed as tumor growth inhibition at 2.5 mg/kg, po qd administered for 18 days post 10 days of implantation	2020	Journal of medicinal chemistry, 05-14, Volume: 63, Issue:9	Discovery of (2
AID1730530	AUC (0 to 24 hrs) in Sprague-Dawley rat assessed as AZ5104 at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1730529	Elimination half life in Sprague-Dawley rat assessed as AZ5104 at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1484432	Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 15 mins followed by substrate addition measured after 60 mins by FRET-based Z'-Lyte assay	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1425064	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167120	Unbound fraction in nude mouse plasma	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425028	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1867494	Induction of apoptosis in human PC-9 cells expressing EGFR L858R/T790M/C797S mutant assessed as early apoptotic cells at 0.25 uM incubated for 24 hrs by annexin-V/propidium iodide staining-based flow cytometry analysis (Rvb = 0.3 %)	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1807696	Oral bioavailability in mouse	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1865646	Inhibition of HER2 in human BT474 cells assessed as reduction in autophosphorylation at Y1221/1222 residue at 5 to 100 nM after 6 hrs by Western blot analysis	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1740136	Inhibition of TEL-fused EGFR (unknown origin) transfected in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1424946	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424971	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484445	Intrinsic clearance in rat liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1565417	Antiproliferative activity against human PC9 cells harbouring EGFR delE746-A750 mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
AID1709330	MRT (0 to infinity) in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1898660	Inhibition of human EGFR L858R/T790M double mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1807707	Inhibition of FLT3 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1424995	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1708235	Selectivity ratio of IC50 for antiproliferative activity against human NCI-H292 cells harboring wild-type EGFR to IC50 for antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1708241	Cytotoxicity against human L02 cells assessed as reduction in cell viability by MTT assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1709333	Cmax in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1772744	Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay
AID1425201	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1688930	Induction of apoptosis in human HCC827 cells assessed as necrotic cells at 0.1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 6.68 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1519419	Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 0.462 uM after 24 hrs by AnnexinV-FITC/propidium iodide staining based FACSCalibur flow cytometry analysis (Rvb = 3.51 %)	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1424996	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425148	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424990	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1565418	Antiproliferative activity against human NCI-H1975 cells harbouring EGFR L858R/T790M double mutant assessed as reduction in cell viability incubated for 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Nov-15, Volume: 182	1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC.
AID1724046	Inhibition of EGFR (unknown origin)	2020	Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18	Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
AID1824048	Selectivity index, ratio of IC50 for Antiproliferative activity against human NCI-H1299 cells expressing wild type EGFR to IC50 for antiproliferative activity against human NCI-H1975 cells expressing EGFR T790M/L858R mutant
AID1425212	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167149	Oral bioavailability in Han Wistar rat at 5 mg/kg	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425155	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807714	Inhibition of MAPK8 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1688928	Induction of apoptosis in human HCC827 cells assessed as early apoptotic cells at 0.1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 2.31 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1612550	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1425157	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481369	Inhibition of EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as reduction in Akt phosphorylation at Thr308/Ser473 site at 1 uM measured after 4 hrs by Western blot analysis	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1167159	Average free plasma concentration in rat at 200 mg/kg, po as single dose at 24 hrs	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1167167	Toxicity in rat assessed as increase insulin level at 200 mg/kg, po as single dose measured over 24 hrs relative to control	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1730550	Tmax in Sprague-Dawley rat at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1527519	Inhibition of phosphorylated EGFR del19/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells incubated for 4 hrs by Alphascreen assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1425058	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390641	Antiproliferative activity against human A431 cells harboring wild-type EGFR after 72 hrs by MTT assay
AID1867493	Induction of apoptosis in human PC-9 cells expressing EGFR L858R/T790M/C797S mutant assessed as viable cells at 0.25 uM incubated for 24 hrs by annexin-V/propidium iodide staining-based flow cytometry analysis (Rvb = 99.1 %)	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1291342	Drug metabolism in mouse assessed as AUC of AZ7550 at 25 mg/kg, po relative to parent compound	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Recent progress on third generation covalent EGFR inhibitors.
AID1688929	Induction of apoptosis in human HCC827 cells assessed as late apoptotic cells at 0.1 uM incubated for 32 hrs by annexin V-FITC and PI staining based flow cytometry analysis (Rvb = 14.23 %)	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1519412	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1382532	Inhibition of wild type EGFR (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1461710	Antiproliferative activity against human BEAS2B cells after 72 hrs by MTS assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1815790	Selectivity ratio of IC50 for wild type EGFR (unknown origin) to IC50 for EGFR L858R/T790M/C797S triple mutant (unknown origin) measured by ELISA	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1865382	Inhibition of EGFR L858R/T790M mutant expressed in human NCI-H1975 cells	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1425020	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664398	Antiproliferative activity against human A431 cells overexpressing EGFR assessed as reduction in cell viability by CCK8 assay
AID1424892	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390664	Inhibition of recombinant human full length His-tagged CHK1 expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1807698	Inhibition of EGF-induced phosphorylation of wild type EGFR in human LoVo cells preincubated for 2 hrs followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1815227	Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured at 1 uM by ELISA	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1390655	Inhibition of recombinant full-length human His-tagged GSK3beta expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1425150	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1441942	Reversible inhibition of human N-terminal GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate assessed as inactivation constant preincubat	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1424955	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425057	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424895	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425146	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1909242	Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISA
AID1730454	Antiproliferative activity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by sulforhodamine B assay	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1498610	Inhibition of EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 2 hrs followed by compound washout measured up to 24 hrs by Western blot method	2018	Journal of medicinal chemistry, 07-12, Volume: 61, Issue:13	Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1425043	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425001	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425051	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865632	Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M mutant after 72 hrs by resazurin dye-based fluorescence assay	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1498611	Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as reduction in ERK1/2 phosphorylation preincubated for 2 hrs followed by compound washout measured after 12 hrs by Western blot method	2018	Journal of medicinal chemistry, 07-12, Volume: 61, Issue:13	Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1519417	Antiproliferative activity against human NCI-H1975 cells harboring EGFR T790M/L858R double mutant assessed as inhibition of cell growth after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1359370	Selectivity ratio of IC50 for recombinant human GST-tagged wild type EGFR to IC50 for recombinant human GST-tagged EGFR T790M/L858R double mutant
AID1872385	Inhibition of cell growth in human multiple BC cells bearing EZH2 T790M mutant	2022	European journal of medicinal chemistry, Mar-05, Volume: 231	Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs.
AID1616560	Inhibition of GST-tagged human EGFR D770GY mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
AID1424939	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1771721	Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as inhibition of EGF-stimulated receptor phosphorylation at 1 uM incubated for 4 hrs followed by EGF stimulation for 10 mins by western blot analys
AID1391277	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1425011	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1664401	Selectivity index, ratio of IC50 for human A431 cells overexpressing EGFR assessed as reduction in cell viability by CCK8 assay to IC50 for human NCI-H1975 cells harboring EGFR 19D/T790M assessed as reduction in cell viability by CCK8 assay
AID1167109	Inhibition of human ERG	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1484454	Cmax in Sprague-Dawley rat at 10 mg/kg, po administered via gavage after 24 hrs by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1424925	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1848536	Inhibition of N-terminal GST-tagged human recombinant EGFR T790M/L858R mutant (695 to end residues) expressed in baculovirus-infected Sf9 cells using poly (4:1 Glu,Tyr) peptide as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assay
AID1425177	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807692	Inhibition of wild type EGFR (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mins in presence of ATP by IMAP-FP assay	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1441931	Ratio of Kinact to Ki for human N-terminal GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1484446	Intrinsic clearance in dog liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1425196	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167164	Toxicity in rat at 200 mg/kg, po as single dose measured over 24 hrs	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1583838	Inhibition of GST-tagged human EGFR T790M/L858R double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1167102	Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assay	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1167170	Drug metabolism in mouse plasma assessed as loss of indole N-methyl group	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1274046	Inhibition of wild type EGFR (unknown origin)	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
AID1585289	Antiproliferative activity against human Calu3 cells harboring WT EGFR after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1425025	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425089	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1896794	Antiproliferative activity against mouse BaF3 cells expressing L858R assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1738671	Inhibition of N-terminal GST-fused human wild type EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus expression system using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate incubated for 20 mins by Mobility shift assay	2020	European journal of medicinal chemistry, Aug-01, Volume: 199	Discovery of new thieno[3,2-d]pyrimidine derivatives targeting EGFR
AID1382535	Inhibition of wild type EGFR L858R/T790M/C797S mutant (unknown origin) using Poly (Glu, Tyr) as substrate after 40 mins by kinase-Glo luminescence assay	2018	European journal of medicinal chemistry, Mar-25, Volume: 148	Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
AID1425137	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484459	Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1481310	Inhibition of Tel-fused EGFR T790M mutant (unknown origin) expressed in mouse BAF3 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1585979	Growth inhibition of human NCI-H1975 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-15, Volume: 162	Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.
AID1704925	Antiproliferative activity against human H1975 cells expressing EGFR L858R/T790M mutant assessed as cell growth inhibition measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Discovery of potent small molecule PROTACs targeting mutant EGFR.
AID1612547	Selectivity ratio of IC50 for wild-type EGFR (unknown origin) to IC50 for EGFR T790M/L858R double mutant (unknown origin)	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1424952	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583862	Inhibition of EGFR in human DFCI032 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1656715	Inhibition of wild type EGFR (unknown origin)	2020	Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3	Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones.
AID1730456	Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R/T790M mutant incubated for 72 hrs by Cell Titer-Glo luminescent assay	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1585291	Selectivity index, ratio of IC50 for human Calu3 cells harboring WT EGFR to IC50 for human NCI-H1975 cells harboring EGFR T790M/L858R double mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1583835	Inhibition of GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1585303	Inhibition of WT EGFR in human A431 cells assessed as reduction in ERK phosphorylation at T202/Y204 residues up to 10 uM after 4 hrs by Western blot analysis	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1497678	Inhibition of wild type EGFR (unknown origin) using Poly(Glu,Tyr) as substrate after 40 mins by Kinase-Glo luminescence assay	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1425110	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1458991	Fraction unbound in mouse 100% plasma at 5 uM incubated for 6 hrs by LC-MS method	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1424920	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1703387	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Oct-01, Volume: 203	Design, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations.
AID1771720	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as inhibition of EGF-stimulated receptor phosphorylation at 1 uM incubated for 4 hrs followed by EGF stimulation for 10 mins by western blot analys
AID1708236	Inhibition of recombinant human GST-tagged EGFR T790M/L858R double mutant (668 to 1210 residues) expressed in baculovirus expression system using Tyr 4 as substrate incubated for 60 mins by Z'-Lyte assay	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1425100	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1898661	Inhibition of human EGFR L858R mutant expressed in Sf9 insect cells in presence of ATP measured by HTRF assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1807703	Inhibition of cdk1/Cyclin B (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1730557	Apparent oral clearance in Sprague-Dawley rat at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1815817	Antiproliferative activity against human PC-9 cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 assay	2022	ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2	Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR
AID1425173	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424953	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1807695	Selectivity ratio of EC50 for inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H1975 cells to EC50 for inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins f	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1519411	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1390644	Inhibition of recombinant human His-tagged FLT3 cytoplasmic domain (564 to 958 residues) expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1484447	Intrinsic clearance in monkey liver microsomes	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1461712	Inhibition of EGFR L858R/T790M mutant (unknown origin) using Tyr 4 peptide as substrate in presence of ATP by Z-LYTE kinase assay	2017	Bioorganic & medicinal chemistry, 09-01, Volume: 25, Issue:17	Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.
AID1425067	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1861555	Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M incubated for 72 hrs by CCK-8 assay	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1607089	Toxicity in NCr nude mouse xenografted with human NCI-H1975 cells harboring EGFR T790M mutant assessed as effect on body weight at 2.5 mg/kg, po qd administered for 18 days post 10 days of implantation	2020	Journal of medicinal chemistry, 05-14, Volume: 63, Issue:9	Discovery of (2
AID1599832	Cytotoxicity against mouse BAF3 cells incubated for 72 hrs by resazurin dye based assay	2019	ACS medicinal chemistry letters, Jun-13, Volume: 10, Issue:6	Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR
AID1771725	Cytotoxicity against mouse BaF3 cells harboring EGFR del19/T790M/C797S triple mutant assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
AID1688919	Inhibition of EGFR in human HCC827 cells assessed as reduction in Akt phosphorylation incubated for 36 hrs by Western blot analysis	2020	European journal of medicinal chemistry, Mar-01, Volume: 189	Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).
AID1424942	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1583839	Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay	2017	European journal of medicinal chemistry, Aug-18, Volume: 136	Discovery of a potent dual ALK and EGFR T790M inhibitor.
AID1425015	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425065	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425136	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1483369	Inhibition of EGFR L858R/T790M double mutant (unknown origin)	2017	Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11	Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.
AID1425033	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1884790	Inhibition of EGFR L858R/T790M mutant (unknown origin) by mobility shift assay
AID1709332	Tmax in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1815228	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured by MTT assay	2021	European journal of medicinal chemistry, Dec-15, Volume: 226	Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors.
AID1612549	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1612545	Inhibition of wild-type EGFR (unknown origin) using substrate-biotin by ELISA-based mobility shift assay	2019	European journal of medicinal chemistry, Feb-01, Volume: 163	Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR
AID1425185	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1424967	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425115	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585302	Inhibition of WT EGFR phosphorylation at Y1068 residue in human A431 cells up to 10 uM after 4 hrs by Western blot analysis	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1708240	Selectivity ratio of IC50 for HK-2 cells to IC50 for antiproliferative activity against human NCI-H1975 cells	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1904354	Antiproliferative activity against human PC-9 cells expressing EGFR deletion19 mutant assessed as inhibition of cell proliferation	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1425059	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1458981	Antiproliferative activity against human HCC827 cells harboring EGFR-delE746_A750 mutant incubated for 96 hrs measured on day 5 by CellTiterGlo assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1425055	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1730858	Inhibition of EGFR L858R/T790M (unknown origin) by mobility shift assay	2021	European journal of medicinal chemistry, Mar-05, Volume: 213	Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR
AID1702619	Antiproliferative activity against human U-87MG cells harboring wild type EGFR assessed as inhibition of cell growth by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1441937	Reversible inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated for 2 to 90 mins followed by 6-fold dilution	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1730491	Drug metabolism in human liver microsomes assessed as AZ5104 metabolite levels preincubated for 10 mins under shaking condition followed by NADPH generating system addition and measured up to 60 mins by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1807700	Inhibition of EGF-induced phosphorylation of wild type EGFR in human NCI-H2073 cells preincubated for 2 hrs followed by EGF stimulation and measured after 10 mins by ELISA	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1425018	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1519414	Inhibition of EGFR T790M/L858R double mutant (unknown origin) using biotin as substrate in presence of ATP by mobility shift assay based ELISA	2020	European journal of medicinal chemistry, Jan-01, Volume: 185	Design, synthesis and 3D-QSAR analysis of novel thiopyranopyrimidine derivatives as potential antitumor agents inhibiting A549 and Hela cancer cells.
AID1861578	Induction of apoptosis in human NCI-H1975 cells assessed as necrotic cells at 1.0 uM incubated for 48 hrs by AnnexinV-FITC/propidium iodide staining based flow cytometry analysis (Rvb = 3.28 % )	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of highly potent and selective CRBN-recruiting EGFR
AID1481309	Inhibition of EGFR exon 19 deletion mutant in human PC9 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1441940	Reversible inhibition of wild-type human N-terminal GST-tagged EGFR cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate assessed as inactivation constant preincubated for 2 to 90 m	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1898674	Displacement of sapitinib-BODIPY tracer from C-terminal NanoLuc-fused full length wild type EGFR (unknown origin) transfected in HEK293T cells incubated for 2 hrs by NanoBRET assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1424969	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1896795	Antiproliferative activity against mouse BaF3 cells expressing L858R/C797S assessed as cell viability measured after 72 hrs hrs by CellTiter Glo assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1425040	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1481360	Growth inhibition of CHL cells after 72 hrs by CellTiter-Glo assay	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1425165	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585287	Antiproliferative activity against human HCC827 cells harboring EGFR mutant after 72 hrs by MTS assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1702614	Inhibition of human EGFR cytoplasmic domain L858R/T790M mutant (669 to 1210 residues) expressed in baculovirus infected Sf21 cells at 1 uM using biotin-labeled TK substrate preincubated for 30 mins followed by substrate and ATP addition at Km concentratio	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1585285	Selectivity index, ratio of GI50 for human A431 cells harboring WT EGFR to GI50 for human NCI-H1975 cells harboring EGFR T790M/L858R double mutant	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1704923	Antiproliferative activity against human A431 cells expressing wild type EGFR assessed as cell growth inhibition measured after 72 hrs by MTT assay	2020	European journal of medicinal chemistry, Dec-15, Volume: 208	Discovery of potent small molecule PROTACs targeting mutant EGFR.
AID1424960	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1434569	Inhibition of N-terminal 6His/TEV protease cleavage site-tagged human EGFR L858R/T790M double mutant (696 to 1022 residues) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA	2017	European journal of medicinal chemistry, Jan-27, Volume: 126	A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR
AID1412315	Selectivity ratio of IC50 for Wild type human EGFR to IC50 for recombinant human EGFR T790M/L858R double mutant (696 to end residues)
AID1391276	Antiproliferative activity against human HCC827 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.
AID1359379	Antitumor activity against EGFR T790M/L858R double mutant expressing human NCI-H1975 cells xenografted in BALB/c athymic nude mouse assessed as tumor growth inhibition at 10 mg/kg, po bid for 21 days
AID1807701	Inhibition of BRAF (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1898672	Antiproliferative activity against mouse BaF3 cells expressing EGFR L858R/T790M mutant incubated for 72 hrs in presence of 1 ug/ml cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1740141	Inhibition of EGFR L858R mutant in human NCI-H3255 cells assessed as cell growth inhibition measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1458985	Permeability of the compound at 500 uM incubated for 20 hrs by PAMPA	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1730549	Cmax in Sprague-Dawley rat at 6 mg/kg/day, IG administered as single dose and measured up to 24 hrs by LC-MS/MS analysis	2021	Journal of medicinal chemistry, 01-28, Volume: 64, Issue:2	Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer.
AID1585324	Toxicity in castrated nude mouse xenografted with human HCC827 cells assessed as body weight loss at 10 mg/kg, po daily for 14 consecutive days relative to control	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1824085	Induction of apoptosis in human NCI-H1299 cells assessed as increase in viable cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 94.1%)
AID1425066	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585325	Half life in po dosed mouse	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
AID1702618	Antiproliferative activity against human NCI-H1975 cells expressing EGFR L858R/T790M mutant assessed as inhibition of cell growth by MTT assay	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1425210	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1865379	Inhibition of wild type EGFR expressed in human NCI-H2073 cells	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1481439	Induction of apoptosis in human HCC827 cells harboring EGFR exon 19 deletion mutant assessed as caspase-3 cleavage at 1 uM after 48 hrs by immunoblotting	2017	Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7	Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
AID1740148	Cytotoxicity against HUVEC assessed as reduction in cell viability measured after 72 hrs by Celltiter-Glo luminescent cell viability assay	2020	European journal of medicinal chemistry, Sep-15, Volume: 202	Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H
AID1865381	Inhibition of EGFR L858R mutant expressed in human NCI-H3255 cells	2022	Journal of medicinal chemistry, 10-13, Volume: 65, Issue:19	Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
AID1389852	Cytotoxicity against human A549 cells expressing wild-type EGFR/K-ras mutant after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8	Discovery of selective EGFR modulator to inhibit L858R/T790M double mutants bearing a N-9-Diphenyl-9H-purin-2-amine scaffold.
AID1424914	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425008	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1298670	Antiproliferative activity against human A431 cells overexpressing wild-type EGFR after 72 hrs by SRB assay	2016	Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12	Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors.
AID1425068	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1484456	AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po administered via gavage by LC-MS/MS analysis	2017	European journal of medicinal chemistry, Jul-28, Volume: 135	Design, synthesis, SAR discussion, in vitro and in vivo evaluation of novel selective EGFR modulator to inhibit L858R/T790M double mutants.
AID1424991	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1445474	Ratio of Kinact N-terminal GST-fused EGFR T790M/L858R double mutant (669 to 1210 residues) expressed in baculovirus to Ki for human N-terminal GST-fused EGFR T790M/L858R double mutant (669 to 1210 residues) expressed in baculovirus	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1425086	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1390643	Inhibition of human full length Src expressed in baculovirus expression system at 1 uM using tyrosine04 peptide as substrate after 60 mins in presence of ATP by Z-LYTE assay relative to control
AID1425119	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709312	Antitumor activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant xenografted in BALB/c nude mouse assessed as tumor growth inhibition at 5 mg/kg, po administered once daily for 11 days relative to control	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1616563	Cytotoxicity in human A431 cells assessed as reduction in cell viability incubated for 96 hrs by MTS method	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
AID1904311	Protac activity at VHL/EGFR L858R/T790M mutant (unknown origin) assessed as inhibition of EGFR incubated for 40 mins in presence of ATP by Kinase Glo luminescence assay	2022	Journal of medicinal chemistry, 03-24, Volume: 65, Issue:6	Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands.
AID1424974	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1709336	Half life in rat assessed as N-(5-(4-(1H-indol-3-yl)pyrimidin-2-ylamino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide level at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1709327	AUC (0 to 8 hrs) in rat at 5 mg/kg, po by LC-MS analysis	2021	Bioorganic & medicinal chemistry, 04-15, Volume: 36	Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
AID1445469	Inhibition of human N-terminal GST-fused EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated for 30 mins followed by substrate addition measured after 25 mins by HTFR assay	2017	Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13	Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
AID1807715	Inhibition of PLK2 (unknown origin) at 1 uM measured after 1 hr relative to control	2021	Bioorganic & medicinal chemistry letters, 11-15, Volume: 52	Discovery and optimization of covalent EGFR T790M/L858R mutant inhibitors.
AID1824102	Induction of apoptosis in human NCI-H1975 cells assessed as increase in early apoptotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 1.24%)
AID1483367	Inhibition of wild-type EGFR (unknown origin)	2017	Journal of medicinal chemistry, 06-08, Volume: 60, Issue:11	Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping.
AID1424973	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425026	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1425037	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1717446	Inhibition of EGFR L858R/T790M/C797S (unknown origin) using Poly (Glu, Tyr) as substrate measured after 40 mins by kinase-glo assay
AID1824088	Induction of apoptosis in human NCI-H1299 cells assessed as increase in necrotic cells at 2.5 uM after 36 hrs by annexin-V-FITC/PI staining based flow cytometric analysis (Rvb = 0.75%)
AID1708299	Antitumor activity against human NCI-H1975 cells harboring EGFR T790M/L858R mutant xenografted in nude mouse assessed as tumor growth inhibition at 15 mg/kg, po administered once daily for 7 days relative to control	2021	European journal of medicinal chemistry, Feb-15, Volume: 212	Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR
AID1898670	Antiproliferative activity against mouse BaF3 cells expressing wild type EGFR incubated for 72 hrs in presence of 1 ug/ml cetuximab by Cell Titer-Glo assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1896769	Inhibition of wild type EGFR (unknown origin) assessed as percent of control activity at 1 uM by radiometric protein kinase-reaction biology assay	2022	Journal of medicinal chemistry, 12-08, Volume: 65, Issue:23	Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
AID1425202	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1585925	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	2018	Bioorganic & medicinal chemistry, 12-15, Volume: 26, Issue:23-24	The synthesis of 4-arylamido-2-arylaminoprimidines as potent EGFR T790M/L858R inhibitors for NSCLC.
AID1771676	Inhibition of wild type EGFR (unknown origin) using fluoresceine-labelled poly-GT peptide as substrate preincubated with enzyme for 3 hrs followed by substrate and ATP addition by TR-FRET assay
AID1424921	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1167154	Fraction unbound in Han Wistar rat plasma	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1425069	Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry	2017	Science (New York, N.Y.), 12-01, Volume: 358, Issue:6367	The target landscape of clinical kinase drugs.
AID1880129	Inhibition of EGFR L858R/T790M mutant phosphorylation (unknown origin)	2022	Journal of medicinal chemistry, 04-28, Volume: 65, Issue:8	The Ascension of Targeted Covalent Inhibitors.
AID1898665	Inhibition of wild type human EGFR expressed in Sf9 insect cells in presence of ATP measured by HTRF assay	2022	Journal of medicinal chemistry, 01-27, Volume: 65, Issue:2	Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites.
AID1867495	Induction of apoptosis in human PC-9 cells expressing EGFR L858R/T790M/C797S mutant assessed as late apoptotic cells at 0.25 uM incubated for 24 hrs by annexin-V/propidium iodide staining-based flow cytometry analysis (Rvb = 0.14 %)	2022	European journal of medicinal chemistry, Jul-05, Volume: 237	Discovery and structural optimization of potent epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M/C797S resistance mutation for lung cancer treatment.
AID1527522	Cytotoxicity against mouse BAF3 cells incubated for 72 hrs by Celltiter-Glo luminescent cell viability assay	2019	Journal of medicinal chemistry, 11-27, Volume: 62, Issue:22	Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
AID1167121	Intrinsic clearance in rat hepatocytes measured per 10'6 cells	2014	Journal of medicinal chemistry, Oct-23, Volume: 57, Issue:20	Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor.
AID1458983	Antiproliferative activity against human A549 cells harboring KRAS-G12S mutant incubated for 96 hrs measured on day 5 by CellTiterGlo assay	2017	Journal of medicinal chemistry, 09-28, Volume: 60, Issue:18	Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
AID1702615	Inhibition of wild type N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in baculovirus infected Sf21 cells using biotin-labeled TK substrate preincubated for 30 mins followed by substrate and ATP addition at Km concent	2020	European journal of medicinal chemistry, Feb-01, Volume: 187	Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.
AID1441939	Reversible inhibition of human N-terminal GST-tagged EGFR L858R/T790M double mutant cytoplasmic domain (669 to 1210 end amino acid residues) expressed in baculovirus expression system using TK peptide substrate preincubated for 2 to 90 mins followed by 6-	2017	Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6	Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
AID1498607	Inhibition of EGFR L858R/T790M double mutant phosphorylation in EGF-stimulated human NCI-H1975 cells at 1 to 100 nM by Western blot method	2018	Journal of medicinal chemistry, 07-12, Volume: 61, Issue:13	Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
AID1865644	Selectivity ratio of Kinact for human N-terminal GST-tagged EGFR (669 to 1210 residues) (unknown origin) L858R/T790M mutant to Kinact for human N-terminal GST-tagged EGFR wild type (669 to 1210 residues) (unknown origin)	2022	ACS medicinal chemistry letters, Dec-08, Volume: 13, Issue:12	Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448).
AID1497694	Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)	2018	Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12	Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.
AID1804171	DRC analysis by immunofluorescence from Article 10.1128/AAC.00819-20: \\Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.\\	2020	Antimicrobial agents and chemotherapy, 06-23, Volume: 64, Issue:7	Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs.
AID1347412	qHTS assay to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Counter screen cell viability and HiBit confirmation	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347411	qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary	2020	ACS chemical biology, 07-17, Volume: 15, Issue:7	High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1345502	Human epidermal growth factor receptor (Type I RTKs: ErbB (epidermal growth factor) receptor family)	2016	Journal of hematology & oncology, Apr-12, Volume: 9	Third-generation inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	465 (35.88)	24.3611
2020's	831 (64.12)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	134 (10.19%)	5.53%
Reviews	140 (10.65%)	6.00%
Case Studies	273 (20.76%)	4.05%
Observational	22 (1.67%)	0.25%
Other	746 (56.73%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
adenine [no description available]	3.25	4	0	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	3.17	1	0	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
indole [no description available]	7.31	1	0	indole; polycyclic heteroarene	Escherichia coli metabolite
selenious acid Selenious Acid: A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.	2.6	1	0	selenium oxoacid
4,5,6,7-tetrabromo-2-azabenzimidazole 4,5,6,7-tetrabromobenzotriazole: a CK2 kinase inhibitor	3.41	1	0
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	2.31	1	0	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
amodiaquine Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.	3.17	1	0	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	2.66	2	0	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
astemizole Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.. astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.	3.51	1	0	benzimidazoles; piperidines	anti-allergic agent; anticoronaviral agent; H1-receptor antagonist
berberine [no description available]	7.41	1	0	alkaloid antibiotic; berberine alkaloid; botanical anti-fungal agent; organic heteropentacyclic compound	antilipemic drug; antineoplastic agent; antioxidant; EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor; EC 1.21.3.3 (reticuline oxidase) inhibitor; EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.11.10 (IkappaB kinase) inhibitor; EC 3.1.1.4 (phospholipase A2) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; geroprotector; hypoglycemic agent; metabolite; potassium channel blocker
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.21	1	0	aromatic ether; nitrile; polyether; tertiary amino compound
camostat camostat : A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients.	3.17	1	0	benzoate ester; carboxylic ester; diester; guanidines; tertiary carboxamide	anti-inflammatory agent; anticoronaviral agent; antifibrinolytic drug; antihypertensive agent; antineoplastic agent; antiviral agent; serine protease inhibitor
carvedilol [no description available]	2.25	1	0	carbazoles; secondary alcohol; secondary amino compound	alpha-adrenergic antagonist; antihypertensive agent; beta-adrenergic antagonist; cardiovascular drug; vasodilator agent
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	3.83	3	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
cyproheptadine Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.. cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.	3.41	1	0	piperidines; tertiary amine	anti-allergic agent; antipruritic drug; gastrointestinal drug; H1-receptor antagonist; serotonergic antagonist
deferiprone Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia.	3.51	1	0	4-pyridones	iron chelator; protective agent
ebastine [no description available]	3.17	1	0	organic molecular entity
fexofenadine fexofenadine: a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; structure in first source; RN refers to HCl. fexofenadine : A piperidine-based anti-histamine compound.	9.51	1	1	piperidines; tertiary amine	anti-allergic agent; H1-receptor antagonist
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.21	1	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
furosemide Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.	2.25	1	0	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic
fasudil fasudil: intracellular calcium antagonist; structure in first source. fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.	2.15	1	0	isoquinolines; N-sulfonyldiazepane	antihypertensive agent; calcium channel blocker; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; geroprotector; neuroprotective agent; nootropic agent; vasodilator agent
hexachlorophene Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.	3.17	1	0	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	3.51	1	0	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
iodoacetamide [no description available]	2.15	1	0
4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline WHI P131: a quinazoline derivative, inhibitor of glioblastoma cell adhesion and migration	2.15	1	0
nsc 664704 kenpaullone: inhibits CDK1/cyclin B; structure in first source. kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).	3.51	1	0	indolobenzazepine; lactam; organobromine compound	cardioprotective agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; geroprotector
loperamide Loperamide: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.. loperamide : A synthetic piperidine derivative, effective against diarrhoea resulting from gastroenteritis or inflammatory bowel disease.	3.17	1	0	monocarboxylic acid amide; monochlorobenzenes; piperidines; tertiary alcohol	anticoronaviral agent; antidiarrhoeal drug; mu-opioid receptor agonist
loratadine Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.. loratadine : A benzocycloheptapyridine that is 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine substituted by a chloro group at position 8 and a 1-(ethoxycarbonyl)piperidin-4-ylidene group at position 11. It is a H1-receptor antagonist commonly employed in the treatment of allergic disorders.	3.41	1	0	benzocycloheptapyridine; ethyl ester; N-acylpiperidine; organochlorine compound; tertiary carboxamide	anti-allergic agent; cholinergic antagonist; geroprotector; H1-receptor antagonist
mefloquine hydrochloride [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.	3.17	1	0	organofluorine compound; piperidines; quinolines; secondary alcohol
mequitazine mequitazine: RN given refers to parent cpd without isomeric designation; structure	3.17	1	0	phenothiazines
metformin Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.	7.21	1	0	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic
entinostat [no description available]	3.41	1	0	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
ethylmaleimide Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.	2.15	1	0	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor
niclosamide Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.	3.17	1	0	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor
nifedipine Nifedipine: A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.	3.51	1	0	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent
omeprazole Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.	5.91	2	2	aromatic ether; benzimidazoles; pyridines; sulfoxide
oxyphenbutazone Oxyphenbutazone: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27). oxyphenbutazone : A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.	3.51	1	0	phenols; pyrazolidines	antimicrobial agent; antineoplastic agent; antipyretic; drug metabolite; gout suppressant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic metabolite
pd168393 PD 168393 : A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.	2.15	1	0	acrylamides; bromobenzenes; quinazolines; secondary carboxamide; substituted aniline	epidermal growth factor receptor antagonist
perhexiline Perhexiline: 2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.	3.17	1	0	piperidines	cardiovascular drug
phenazopyridine Phenazopyridine: A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.. phenazopyridine : A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.	3.17	1	0	diaminopyridine; monoazo compound	anticoronaviral agent; carcinogenic agent; local anaesthetic; non-narcotic analgesic
propranolol Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.. propranolol : A propanolamine that is propan-2-ol substituted by a propan-2-ylamino group at position 1 and a naphthalen-1-yloxy group at position 3.	2.21	1	0	naphthalenes; propanolamine; secondary amine	anti-arrhythmia drug; antihypertensive agent; anxiolytic drug; beta-adrenergic antagonist; environmental contaminant; human blood serum metabolite; vasodilator agent; xenobiotic
pyrimethamine Maloprim: contains above 2 cpds	3.41	1	0	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
raloxifene raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.	3.51	1	0	1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols	bone density conservation agent; estrogen antagonist; estrogen receptor modulator
imatinib [no description available]	5.27	5	0	aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines	antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
vorinostat Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).	5.29	5	0	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor
terfenadine Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.	4.51	1	1	diarylmethane
thioridazine Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.. thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.	3.17	1	0	phenothiazines; piperidines	alpha-adrenergic antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; first generation antipsychotic; H1-receptor antagonist; serotonergic antagonist
tilorone Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions.. tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.	3.17	1	0	aromatic ether; diether; fluoren-9-ones; tertiary amino compound	anti-inflammatory agent; antineoplastic agent; antiviral agent; interferon inducer; nicotinic acetylcholine receptor agonist
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	2.17	1	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
spironolactone Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.	3.41	1	0	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic
prednisone Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.. prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.	2.31	1	0	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; immunosuppressive agent; prodrug
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	3.04	3	0	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	2.21	1	0	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
aniline [no description available]	2.41	1	0	anilines; primary arylamine
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	3.41	1	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
17-alpha-hydroxyprogesterone 17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.	3.17	1	0	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; tertiary alpha-hydroxy ketone	human metabolite; metabolite; mouse metabolite; progestin
triparanol Triparanol: Antilipemic agent with high ophthalmic toxicity. According to Merck Index, 11th ed, the compound was withdrawn from the market in 1962 because of its association with the formation of irreversible cataracts.	3.17	1	0	stilbenoid	anticoronaviral agent
methacrylaldehyde [no description available]	2.15	1	0	enal
3-buten-2-one buten-2-one : A methyl ketone that is butan-2-one with an unsaturation at position 3.	2.15	1	0	enone; methyl ketone
acrylamide [no description available]	7.63	2	0	acrylamides; N-acylammonia; primary carboxamide	alkylating agent; carcinogenic agent; Maillard reaction product; mutagen; neurotoxin
methylmethacrylate Methylmethacrylate: The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.. methyl methacrylate : An enoate ester having methacrylic acid as the carboxylic acid component and methanol as the alcohol component.	2.15	1	0	enoate ester; methyl ester	allergen; polymerisation monomer
quinoxalines quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.	2.25	1	0	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene
methyl acrylate [no description available]	2.15	1	0	enoate ester
acrolein [no description available]	2.15	1	0	enal	herbicide; human xenobiotic metabolite; toxin
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.66	2	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
ethyl acrylate [no description available]	2.15	1	0	enoate ester
n-butyl acrylate butyl acrylate : An acrylate ester obtained by the formal condensation of the hydroxy group of butan-1-ol with the carboxy group of acrylic acid.	2.15	1	0	acrylate ester
mesityl oxide mesityl oxide: solvent for extraction of nitrocellulose, many resins, & tellurium; structure	2.15	1	0	olefinic compound
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	13.97	40	10	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.13	1	0	indazole
thiazoles [no description available]	4.69	4	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
pyrimidine pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.	7.31	1	0	diazine; pyrimidines	Daphnia magna metabolite
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	8.85	10	4	diazine; pyrazines	Daphnia magna metabolite
apomorphine hydrochloride, anhydrous [no description available]	3.51	1	0
alpha-aminopyridine alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.	2.59	2	0
oleanolic acid [no description available]	2.21	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	2.6	1	0	C-nitro compound; imidazoles	antitubercular agent
ethyl propiolate ethyl propiolate : The ethyl ester of prop-2-ynoic acid.	2.15	1	0	ethyl ester; terminal acetylenic compound; ynoate ester
ethylnitrosourea Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.	2.21	1	0	N-nitrosoureas	alkylating agent; carcinogenic agent; genotoxin; mutagen
cyclopentenone 2-cyclopenten-1-one : An enone that is cyclopentanone having a C=C double bond at position 2.	2.15	1	0	alicyclic ketone; enone	Hsp70 inducer
deoxycytidine [no description available]	2.21	1	0	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
oxyclozanide Oxyclozanide: Anthelmintic used in grazing animals for fasciola and cestode infestations.	3.17	1	0
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	13.09	25	19	elemental platinum; nickel group element atom; platinum group metal atom
(1S,2R)-tranylcypromine (1S,2R)-tranylcypromine : A 2-phenylcyclopropan-1-amine that is the (1S,2R)-enantiomer of tranylcypromine.	3.51	1	0	2-phenylcyclopropan-1-amine
bisbenzimidazole trihydrochloride [no description available]	2.25	1	0
penfluridol Penfluridol: One of the long-acting ANTIPSYCHOTIC AGENTS used for maintenance or long-term therapy of SCHIZOPHRENIA and other PSYCHOTIC DISORDERS.	3.17	1	0	diarylmethane
dehydrocorydalin dehydrocorydalin: alkaloid from Corydalis bulbuso D.C. used in therapy of peptic ulcer; RN given refers to parent cpd	3.51	1	0	alkaloid
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	3.28	5	0	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.17	1	0	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
epirubicin Epirubicin: An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.	2.31	1	0	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
triciribine phosphate [no description available]	2.15	1	0
staurosporine [no description available]	2.57	2	0	indolocarbazole alkaloid; organic heterooctacyclic compound	apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector
simvastatin Simvastatin: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.. simvastatin : A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.	5.88	4	1	delta-lactone; fatty acid ester; hexahydronaphthalenes; statin (semi-synthetic)	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; ferroptosis inducer; geroprotector; prodrug
itraconazole Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.	2.17	1	0	aromatic ether; conazole antifungal drug; cyclic ketal; dichlorobenzene; dioxolane; N-arylpiperazine; triazole antifungal drug; triazoles	EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; Hedgehog signaling pathway inhibitor; P450 inhibitor
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	2.21	1	0	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
3-methyl-2-butenal 3-methylbut-2-enal : An enal consisting of but-2-ene with a methyl substituent at position 3 and an oxo group at position 1.	2.15	1	0	enal	metabolite
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	3.51	1	0	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
bendamustine [no description available]	3.78	2	0	benzimidazoles
alpha-methylene gamma-butyrolactone alpha-methylene gamma-butyrolactone : A butan-4-olide having a methylene group at the 3-position.	2.15	1	0	butan-4-olide	anti-ulcer drug; gastrointestinal drug
fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)	2.31	1	0	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose
honokiol [no description available]	7.25	1	0	biphenyls
columbamine [no description available]	3.51	1	0	berberine alkaloid; organic heterotetracyclic compound
picropodophyllin picropodophyllin: isolated from American May apple (Podophyllum); inhibits IGF-I autophosphorylation without interfering with tyrosine kinase activity. picropodophyllotoxin : An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.	2.15	1	0	furonaphthodioxole; lignan; organic heterotetracyclic compound	antineoplastic agent; insulin-like growth factor receptor 1 antagonist; plant metabolite; tyrosine kinase inhibitor
tetrandrine tetrandrine: a bisbenzylisoquinoline that exhibits antifibrogenic activity	3.17	1	0	bisbenzylisoquinoline alkaloid; isoquinolines
hederagenin [no description available]	2.21	1	0	dihydroxy monocarboxylic acid; pentacyclic triterpenoid; sapogenin	plant metabolite
lopinavir [no description available]	3.57	2	0	amphetamines; dicarboxylic acid diamide	anticoronaviral agent; antiviral drug; HIV protease inhibitor
osajin osajin: from Maclura pomifera	3.17	1	0	isoflavanones
diosgenin [no description available]	2.31	1	0	3beta-sterol; hexacyclic triterpenoid; sapogenin; spiroketal	antineoplastic agent; antiviral agent; apoptosis inducer; metabolite
n-(2'-(dimethylamino)ethyl)acridine-4-carboxamide [no description available]	3.41	1	0
higenamine higenamine: structure; RN given refers to (+-)-isomer	3.51	1	0	norcoclaurine
tanshinone tanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent	3.51	1	0	abietane diterpenoid	anticoronaviral agent
imatinib mesylate imatinib methanesulfonate : A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	2.69	2	0	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor
gefitinib [no description available]	17.03	117	20	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
lestaurtinib [no description available]	2.15	1	0	indolocarbazole
docetaxel anhydrous Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.	5.64	5	1	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent
perifosine [no description available]	2.15	1	0	ammonium betaine; phospholipid	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
lonafarnib lonafarnib: inhibitor of farnesyl protein transferase. lonafarnib : A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase inhibitor.	3.51	1	0	4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide	antineoplastic agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor
levofloxacin Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.	3.41	1	0	9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; fluoroquinolone antibiotic; quinolone antibiotic	antibacterial drug; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; topoisomerase IV inhibitor
vatalanib [no description available]	2.15	1	0	monochlorobenzenes; phthalazines; pyridines; secondary amino compound	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist
oleanolic acid 3-acetate oleanolic acid 3-acetate: from Gardenia jasminoides; RN given for (3beta)-isomer	2.21	1	0
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	7.25	1	0	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
ruboxistaurin ruboxistaurin: inhibits protein kinase C beta; structure in first source	2.15	1	0
bazedoxifene [no description available]	8.68	2	0	phenylindole
canertinib [no description available]	3.44	6	0	monochlorobenzenes; morpholines; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor
cyc 202 seliciclib : 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.	2.15	1	0	2,6-diaminopurines	antiviral drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
epiberberine epiberberine: isolated in plants of Coptis from China	3.51	1	0
anidulafungin Anidulafungin: Echinocandin antifungal agent that is used in the treatment of CANDIDEMIA and CANDIDIASIS.. anidulafungin : A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.	3.17	1	0	antibiotic antifungal drug; azamacrocycle; echinocandin; heterodetic cyclic peptide; semisynthetic derivative
anemodeanin a anemodeanin A: RN given refers to (3beta)-isomer; from Anemone raddeana Regel; structure given in first source	2.6	1	0
sb 203580 [no description available]	3.51	1	0	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent
enzastaurin [no description available]	2.15	1	0	indoles; maleimides
erlotinib [no description available]	6.61	17	0	aromatic ether; quinazolines; secondary amino compound; terminal acetylenic compound	antineoplastic agent; epidermal growth factor receptor antagonist; protein kinase inhibitor
erlotinib hydrochloride [no description available]	16.14	85	20	hydrochloride; terminal acetylenic compound	antineoplastic agent; protein kinase inhibitor
acetylcorynoline [no description available]	2.6	1	0	benzophenanthridine alkaloid
dronedarone Dronedarone: A non-iodinated derivative of amiodarone that is used for the treatment of ARRHYTHMIA.. dronedarone : A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias.	3.17	1	0	1-benzofurans; aromatic ether; aromatic ketone; sulfonamide; tertiary amino compound	anti-arrhythmia drug; environmental contaminant; xenobiotic
lapatinib [no description available]	4.59	6	0	furans; organochlorine compound; organofluorine compound; quinazolines	antineoplastic agent; tyrosine kinase inhibitor
deferasirox Deferasirox: A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.. deferasirox : A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.	3.51	1	0	benzoic acids; monocarboxylic acid; phenols; triazoles	iron chelator
sorafenib [no description available]	4.55	3	0	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide	angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor
lenalidomide [no description available]	7.66	2	0	aromatic amine; dicarboximide; isoindoles; piperidones	angiogenesis inhibitor; antineoplastic agent; immunomodulator
n-phenylacrylamide N-phenylacrylamide: structure in first source	2.15	1	0
berbamine [no description available]	3.17	1	0	bisbenzylisoquinoline alkaloid; isoquinolines
wortmannin [no description available]	3.73	2	0	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent
ritonavir Ritonavir: An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.. ritonavir : An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver.	2.25	1	0	1,3-thiazoles; carbamate ester; carboxamide; L-valine derivative; ureas	antiviral drug; environmental contaminant; HIV protease inhibitor; xenobiotic
carboplatin [no description available]	11.11	14	9
cysteinylglycine cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.	2.25	1	0	dipeptide zwitterion; dipeptide	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
ouabain Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.	3.17	1	0	11alpha-hydroxy steroid; 14beta-hydroxy steroid; 5beta-hydroxy steroid; alpha-L-rhamnoside; cardenolide glycoside; steroid hormone	anti-arrhythmia drug; cardiotonic drug; EC 2.3.3.1 [citrate (Si)-synthase] inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; ion transport inhibitor; plant metabolite
digitoxin Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.	3.17	1	0	cardenolide glycoside	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
ginsenoside rf ginsenoside Rf: from ginseng. ginsenoside Rf : A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.	3.51	1	0	12beta-hydroxy steroid; 20-hydroxy steroid; 3beta-hydroxy-4,4-dimethylsteroid; 3beta-hydroxy steroid; beta-D-glucoside; disaccharide derivative; ginsenoside; tetracyclic triterpenoid	antineoplastic agent; apoptosis inducer; plant metabolite
vernolepin [no description available]	2.15	1	0	delta-lactone
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	7.76	2	0
trichostatin a trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES	3.41	1	0	antibiotic antifungal agent; hydroxamic acid; trichostatin	bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	7.41	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
zithromax Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.	3.41	1	0	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic
shikonin shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities	2.25	1	0	hydroxy-1,4-naphthoquinone
cinnamaldehyde 3-phenylprop-2-enal : A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name "cinnamaldehyde" is widely used to refer to the E (trans) isomer.. (E)-cinnamaldehyde : The E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes.	2.15	1	0	3-phenylprop-2-enal; cinnamaldehydes	antifungal agent; EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor; flavouring agent; hypoglycemic agent; plant metabolite; sensitiser; vasodilator agent
chalcone trans-chalcone : The trans-isomer of chalcone.	2.15	1	0	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.21	1	0	stilbene
dibenzylidene acetone dibenzylidene acetone: structure in first source	2.15	1	0
s 1033 [no description available]	2.15	1	0	(trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor
lanatoside c lanatoside C: RN given refers to (3beta,5beta,12beta)-isomer	3.17	1	0
sesquiterpenes [no description available]	2.41	1	0
parthenolide, (1ar-(1ar,4e,7as,10as,10br))-isomer [no description available]	2.25	1	0	germacranolide
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	8.01	3	0	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
capsaicin ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.	3.51	1	0	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker
zuclomiphene Zuclomiphene: The cis or (Z)-isomer of clomiphene.	3.17	1	0	stilbenoid
xl147 [no description available]	2.15	1	0	aromatic amine; benzothiadiazole; quinoxaline derivative; sulfonamide	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	3.17	1	0	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
toremifene Toremifene: A first generation selective estrogen receptor modulator (SERM). Like TAMOXIFEN, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.	3.17	1	0	aromatic ether; organochlorine compound; tertiary amine	antineoplastic agent; bone density conservation agent; estrogen antagonist; estrogen receptor modulator
bms 387032 N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide: a CDK2 inhibitor with antineoplastic activity; structure in first source. N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties.	2.15	1	0	1,3-oxazoles; 1,3-thiazoles; organic sulfide; piperidinecarboxamide; secondary carboxamide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
droloxifene [no description available]	3.17	1	0	stilbenoid
sf 2370 SF 2370: indolocarbazole isolated from Actinomadura sp. SF-2370; structure given in first source. K-252a : A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a	2.15	1	0	bridged compound; gamma-lactam; methyl ester; organic heterooctacyclic compound	antimicrobial agent; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; tropomyosin-related kinase B receptor antagonist
tandutinib [no description available]	2.15	1	0	aromatic ether; N-arylpiperazine; N-carbamoylpiperazine; phenylureas; piperidines; quinazolines; tertiary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
dasatinib N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1,3-thiazole-5-carboxamide: a dasatinib prodrug; structure in first source. dasatinib (anhydrous) : An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).	4.99	5	0	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor
ha 1100 HA 1100: intracellular calcium antagonist	2.15	1	0
7-epi-hydroxystaurosporine [no description available]	2.15	1	0
zd 6474 CH 331: structure in first source	5.44	6	0	aromatic ether; organobromine compound; organofluorine compound; piperidines; quinazolines; secondary amine	antineoplastic agent; tyrosine kinase inhibitor
salinomycin salinomycin: from Streptomyces albus; RN given refers to parent cpd; structure	3.17	1	0	polyketide; spiroketal	animal growth promotant; potassium ionophore
ginsenosides ginsenoside : Triterpenoid saponins with a dammarane-like skeleton originally isolated from ginseng (Panax) species. Use of the term has been extended to include semi-synthetic derivatives.	2.25	1	0
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	2.31	1	0
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.25	1	0
alsterpaullone alsterpaullone: structure in first source. alsterpaullone : An organic heterotetracyclic compound that is 1,3-dihydro-2H-1-benzazepin-2-one which shares its 4-5 bond with the 3-2 bond of 5-nitro-1H-indole.	3.51	1	0	C-nitro compound; caprolactams; organic heterotetracyclic compound	anti-HIV-1 agent; antineoplastic agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor
imd 0354 N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide: a cardioprotective agent that inhibits IkappaB kinase beta (IKKbeta); structure in first source	2.15	1	0	benzamides
biochanin a [no description available]	3.51	1	0	4'-methoxyisoflavones; 7-hydroxyisoflavones	antineoplastic agent; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
cholecalciferol Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	3.41	1	0	D3 vitamins; hydroxy seco-steroid; seco-cholestane; secondary alcohol; steroid hormone	geroprotector; human metabolite
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.21	1	0	hydroxycoumarin	fluorescent probe; food component; plant metabolite
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	3.51	1	0	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
pterostilbene [no description available]	7.21	1	0	diether; methoxybenzenes; stilbenol	anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; neuroprotective agent; neurotransmitter; plant metabolite; radical scavenger
rosmarinic acid rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.	3.51	1	0	rosmarinic acid	geroprotector; plant metabolite
wedelolactone wedelolactone: antihepatotoxic coumestan from Eclipta prostrata and Wedelia calendulacea (both Asteraceae); structure given in first source. wedelolactone : A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.	3.51	1	0	aromatic ether; coumestans; delta-lactone; polyphenol	antineoplastic agent; apoptosis inducer; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; hepatoprotective agent; metabolite
2-octenal 2-octenal: RN given refers to cpd without isomeric designation. (E)-oct-2-enal : The (E)-isomer of oct-2-enal.. oct-2-enal : An enal consisting of oct-2-ene having an oxo group at the 1-position.	2.15	1	0	oct-2-enal	antifungal agent; volatile oil component
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	3.17	1	0	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
proscillaridin Proscillaridin: A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).	3.17	1	0	organic molecular entity
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	3.73	2	0	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
alvocidib alvocidib: structure given in first source. alvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	2.15	1	0	dihydroxyflavone; hydroxypiperidine; monochlorobenzenes; tertiary amino compound	antineoplastic agent; antirheumatic drug; apoptosis inducer; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
15-deoxy-delta(12,14)-prostaglandin j2 15-deoxy-delta(12,14)-prostaglandin J2: 15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions. 15-deoxy-Delta(12,14)-prostaglandin J2 : A prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions.	2.15	1	0	prostaglandins J	electrophilic reagent; insulin-sensitizing drug; metabolite
licochalcone a licochalcone A: has both anti-inflammatory and antineoplastic activities; structure given in first source; isolated from root of Glycyrrhiza inflata; RN given refers to (E)-isomer	2.31	1	0	chalcones
casein kinase ii Casein Kinase II: A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulatory subunit. Casein kinase II has been shown to phosphorylate a large number of substrates, many of which are proteins involved in the regulation of gene expression.	3.41	1	0
bosutinib 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile: a Src kinase inhibitor; structure in first source	2.15	1	0	aminoquinoline; aromatic ether; dichlorobenzene; N-methylpiperazine; nitrile; tertiary amino compound	antineoplastic agent; tyrosine kinase inhibitor
orantinib orantinib: an antiangiogenic agent. orantinib : An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1.	2.15	1	0
su 11248 [no description available]	2.15	1	0	monocarboxylic acid amide; pyrroles	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; immunomodulator; neuroprotective agent; vascular endothelial growth factor receptor antagonist
palbociclib [no description available]	7.59	2	0	aminopyridine; aromatic ketone; cyclopentanes; piperidines; pyridopyrimidine; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
ramipril Ramipril: A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.. ramipril : A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.. quark : Quarks comprise one of two classes of the fundamental particles. Quarks possess fractional electric charges and are not observed in free state. The word "quark" first appears in James Joyce's Finnegans Wake and has been chosen by Murray Gell-Mann as a name for fundamental building blocks of particles.	2.17	1	0	azabicycloalkane; cyclopentapyrrole; dicarboxylic acid monoester; dipeptide; ethyl ester	bradykinin receptor B2 agonist; cardioprotective agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; matrix metalloproteinase inhibitor; prodrug
2-pentenal 2-pentenal: RN given refers to cpd without isomeric designation. 2-pentenal : An enal consisting of pent-2-ene having an oxo group at the 1-position. (E)-2-pentenal : A 2-pentenal in which the double bond has (E)-configuration. It is found in cigarette smoke, virgin olive oil, and milk.	2.15	1	0	2-pentenal	plant metabolite
costunolide [no description available]	7.41	1	0
enalapril Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.. enalapril : A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).	2.25	1	0	dicarboxylic acid monoester; dipeptide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; geroprotector; prodrug
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	10.57	4	1	cysteinium	fundamental metabolite
vx680 [no description available]	2.15	1	0	N-arylpiperazine
arglabin arglabin: a sesquiterpene lactone from the Chinese herb Artemisia myriantha; structure given in first source. arglabin : An organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the adduct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.	2.15	1	0	epoxide; gamma-lactone; organic heterotetracyclic compound; sesquiterpene lactone	antineoplastic agent; metabolite
22,23-dihydroavermectin b(1)a 22,23-dihydroavermectin B(1)a: C48H74O14; major component of IVERMECTIN; MW 875.093; structure given in first source. 22,23-dihydroavermectin B1a : A macrocyclic lactone that is avermectin B1a in which the double bond present in the spirocyclic ring system has been reduced to a single bond. It is the major component of ivermectin.	3.51	1	0	macrocyclic lactone; spiroketal
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	2.6	1	0	chalcogen; nonmetal atom	micronutrient
cyc 116 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine: an aurora kinase inhibitor; structure in first source	2.15	1	0
ergonovine maleate ergometrine maleate : A maleate salt resulting form the reaction of equimolar amounts of maleic acid and ergometrine. It is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced.	3.51	1	0	maleate salt	diagnostic agent; oxytocic
9-oxo-15-hydroxy-delta 7,10,13-prostatrienoic acid methyl ester [no description available]	2.15	1	0
yuanhuadine [no description available]	2.21	1	0	diterpenoid	metabolite
everolimus [no description available]	3.73	2	0	cyclic acetal; cyclic ketone; ether; macrolide lactam; primary alcohol; secondary alcohol	anticoronaviral agent; antineoplastic agent; geroprotector; immunosuppressive agent; mTOR inhibitor
ekb 569 EKB 569: an EGF receptor kinase inhibitor	2.15	1	0	aminoquinoline; monocarboxylic acid amide; monochlorobenzenes; nitrile	protein kinase inhibitor
axitinib [no description available]	2.15	1	0	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist
ci 940 leptomycin : A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19.	2.15	1	0	hydroxy polyunsaturated fatty acid; leptomycin	antifungal agent; bacterial metabolite
ciclesonide ciclesonide: nasal spray approved for seasonal and perennial allergic rhinitis	3.17	1	0	organic molecular entity
temsirolimus [no description available]	2.15	1	0	macrolide lactam
on 01910 ON 01910: a Plk1 inhibitor with antineoplastic activity; structure in first source. N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine : A glycine derivative that is glycine in which one of the hydrogens of the amino group is substituted by a 2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl group.. rigosertib : An N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties.	2.15	1	0	N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine	antineoplastic agent; apoptosis inducer; EC 2.7.11.21 (polo kinase) inhibitor; microtubule-destabilising agent
panobinostat Panobinostat: An indole and hydroxamic acid derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used as an antineoplastic agent in combination with BORTEZOMIB and DEXAMETHASONE for the treatment of MULTIPLE MYELOMA.. panobinostat : A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.	7.25	1	0	cinnamamides; hydroxamic acid; methylindole; secondary amino compound	angiogenesis modulating agent; antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor
bufalin bufalin: cardiotonic; powerful anesthetic & one of the active constituents of the Chinese drug ch'an su(senso); in Japan prepared from skin of Bufo bufo garfarizans; RN given refers to (3beta,5beta)-isomer. bufalin : A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.	7.21	1	0	14beta-hydroxy steroid; 3beta-hydroxy steroid	animal metabolite; anti-inflammatory agent; antineoplastic agent; cardiotonic drug
av 412 [no description available]	2.15	1	0
telatinib [no description available]	2.15	1	0
y-39983 Y-39983: SNJ-1656 is an ophthalmic solution of Y-39983; ROCK (rho kinase) inhibitor, promotes regeneration of crushed axons of retinal ganglion cells; structure in first source	2.15	1	0	pyrrolopyridine
cp 547632 3-(4-bromo-2,6-difluorobenzyloxy)-5-(3-(4-pyrrolidin-1-ylbutyl)ureido)isothiazole-4-carboxylic acid amide: inhibits vascular endothelial growth factor receptor-2 tyrosine kinase; structure in first source	2.15	1	0
lenvatinib lenvatinib : A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.	2.61	2	0	aromatic amide; aromatic ether; cyclopropanes; monocarboxylic acid amide; monochlorobenzenes; phenylureas; quinolines	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist; orphan drug; vascular endothelial growth factor receptor antagonist
pd 0325901 mirdametinib: has antineoplastic activity; appears to be a MEK inhibitor. PD 0325901 : A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).	2.15	1	0	difluorobenzene; hydroxamic acid ester; monofluorobenzenes; organoiodine compound; propane-1,2-diols; secondary amino compound	antineoplastic agent; EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor
midostaurin midostaurin : An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.	2.15	1	0	benzamides; gamma-lactam; indolocarbazole; organic heterooctacyclic compound	antineoplastic agent; EC 2.7.11.13 (protein kinase C) inhibitor
px-866 PX-866: inhibitor of phosphoinositide-3-kinase signaling with antitumor activity; structure in first source. PX-866 : An organic heterotetracyclic compound that is obtained from wortmanin via aminolysis of its furan ring by diallyl amine.	2.15	1	0	acetate ester; delta-lactone; organic heterotetracyclic compound; tertiary amino compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
ripasudil [no description available]	2.15	1	0	isoquinolines
fr 148083 5Z-7-oxozeaenol : A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB.	2.15	1	0	aromatic ether; macrolide; phenols; secondary alcohol; secondary alpha-hydroxy ketone	antibacterial agent; antineoplastic agent; metabolite; NF-kappaB inhibitor
osi 930 OSI 930: inhibits both receptor tyrosine kinase Kit and kinase insert domain receptor; structure in first source	2.15	1	0	aromatic amide
scio-469 SCIO-469: a small-molecule p38 mitogen-activated protein (MAP) kinase inhibitor for potential oral therapy for inflammatory disorders; in phase lib clinical trials for rheumatoid arthritis 4/2004. talmapimod : An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties.	2.15	1	0	aromatic amide; aromatic ketone; chloroindole; dicarboxylic acid diamide; indolecarboxamide; monofluorobenzenes; N-acylpiperazine; N-alkylpiperazine	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
cp 724714 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide: CP-724714 is the ((2E)-isomer, 1:1.5 succinate); structure in first source	2.15	1	0	2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; hepatotoxic agent
rivaroxaban Rivaroxaban: A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.. rivaroxaban : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery.	7.41	1	0	aromatic amide; lactam; monocarboxylic acid amide; morpholines; organochlorine compound; oxazolidinone; thiophenes	anticoagulant; EC 3.4.21.6 (coagulation factor Xa) inhibitor
pi103 PI103: pyridofuropyrimidine antineoplastic; a potent inhibitor of class I phosphatidylinositide 3-kinases (PI3K); structure in first soruce	2.31	1	0	aromatic amine; morpholines; organic heterotricyclic compound; phenols; tertiary amino compound	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor
hmn-214 (E)-4-(2-(2-(N-acetyl-N-(4-methoxybenzenesulfonyl)amino)stilbazole)) 1-oxide: an antineoplastic agent; structure in first source	2.15	1	0
tivozanib N-(2-chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea: KNR-951 is the HCl, monohydrate salt; an antineoplastic agent; structure in first source	2.15	1	0	aromatic ether
hki 272 [no description available]	4.93	9	0	nitrile; quinolines	antineoplastic agent; tyrosine kinase inhibitor
ginsenoside rg3 ginsenoside Rg3: from Red ginseng; inhibits lung metastasis of tumor cells; structure given in first source. (20S)-ginsenoside Rg3 : A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.	7.25	1	0	ginsenoside; glycoside; tetracyclic triterpenoid	angiogenesis modulating agent; antineoplastic agent; apoptosis inducer; plant metabolite
tofacitinib tofacitinib : A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.	3.97	3	0	N-acylpiperidine; nitrile; pyrrolopyrimidine; tertiary amino compound	antirheumatic drug; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
cediranib [no description available]	2.15	1	0	aromatic ether
masitinib [no description available]	2.15	1	0	1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines	antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor
ly-2157299 LY-2157299: an orally active transforming growth factor beta receptor (TGF-beraR) kinase inhibitor. LY-2157299 : A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.	2.15	1	0	aromatic amide; methylpyridines; monocarboxylic acid amide; pyrrolopyrazole; quinolines	antineoplastic agent; TGFbeta receptor antagonist
pazopanib pazopanib: a protein kinase inhibitor. pazopanib : A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.	2.15	1	0	aminopyrimidine; indazoles; sulfonamide	angiogenesis modulating agent; antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist
azd 6244 AZD 6244: a MEK inhibitor	5.87	7	1	benzimidazoles; bromobenzenes; hydroxamic acid ester; monochlorobenzenes; organofluorine compound; secondary amino compound	anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
su 14813 5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide: has both antineoplastic and antiangiogenic activities; structure in first source	2.15	1	0
apilimod [no description available]	3.51	1	0
bibw 2992 [no description available]	15.37	113	7	aromatic ether; enamide; furans; monochlorobenzenes; organofluorine compound; quinazolines; secondary carboxamide; tertiary amino compound	antineoplastic agent; tyrosine kinase inhibitor
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.31	1	0
binimetinib binimetinib : A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.	2.59	2	0	benzimidazoles; bromobenzenes; hydroxamic acid ester; monofluorobenzenes; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
sotrastaurin sotrastaurin: a potent protein kinase C-selective inhibitor; structure in first source. sotrastaurin : A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients.	2.15	1	0	indoles; maleimides; N-alkylpiperazine; N-arylpiperazine; quinazolines	anticoronaviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunosuppressive agent
aee 788 AEE 788: structure in first source	2.63	2	0	6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; epidermal growth factor receptor antagonist; trypanocidal drug
saracatinib [no description available]	3.73	2	0	aromatic ether; benzodioxoles; diether; N-methylpiperazine; organochlorine compound; oxanes; quinazolines; secondary amino compound	anticoronaviral agent; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; radiosensitizing agent
vx 702 VX 702: a p38 MAP kinase inhibitor	2.15	1	0	phenylpyridine
crenolanib [no description available]	2.15	1	0	aminopiperidine; aromatic ether; benzimidazoles; oxetanes; quinolines; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
tg100-115 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol: for treatment of ischemia reperfusion injury; structure in first source	2.15	1	0	pteridines
cc 401 CC 401: an anthrapyrazolone	2.15	1	0	pyrazoles; ring assembly
bms 599626 [no description available]	2.63	2	0
exel-7647 tesevatinib : A member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties.	2.15	1	0
volasertib BI 6727: a polo-like kinase inhibitor with broad antitumor activity; structure in first source	2.15	1	0
pyrrocidine a pyrrocidine A: an antifungal antibiotic isolated from Acremonium zeae; structure in first souce	2.15	1	0
azd 7762 [no description available]	2.15	1	0	aromatic amide; thiophenes
regorafenib [no description available]	2.15	1	0	(trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; monofluorobenzenes; phenylureas; pyridinecarboxamide	antineoplastic agent; hepatotoxic agent; tyrosine kinase inhibitor
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one [no description available]	2.15	1	0	methoxybenzenes; substituted aniline
brivanib [no description available]	2.15	1	0	aromatic ether; diether; fluoroindole; pyrrolotriazine; secondary alcohol	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; drug metabolite; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; fibroblast growth factor receptor antagonist
lurasidone hydrochloride Lurasidone Hydrochloride: A thiazole derivative and atypical ANTIPSYCHOTIC AGENT that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST; SEROTONIN 5-HT2 RECEPTOR ANTAGONIST, serotonin 5-HT7 receptor antagonist, and antagonist of the adrenergic α2A and α2C receptors, as well as a partial SEROTONIN 5-HT1A RECEPTOR AGONIST. It is used in the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER.. lurasidone hydrochloride : A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia.	2.31	1	0	hydrochloride	adrenergic antagonist; dopaminergic antagonist; second generation antipsychotic; serotonergic antagonist
mp470 [no description available]	2.15	1	0	N-arylpiperazine
rgb 286638 [no description available]	2.15	1	0
np 031112 tideglusib: an NSAID and neuroprotective agent. tideglusib : A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.	3.73	2	0	benzenes; naphthalenes; thiadiazolidine	anti-inflammatory agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent
nu 7441 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one: structure in first source	2.31	1	0	dibenzothiophenes
at 7519 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-pyrazole-3-carboxamide : A member of the class of pryrazoles that is 4-amino-1H-pyrazole-3-carboxylic acid in which the primary amino group has been acylated by a 2,6-dichlorobenzoyl group and in which the carboxylic acid has been converted into a carboxamide by formal condensation with the primary amino group of 4-aminopiperidine.	2.15	1	0	dichlorobenzene; piperidines; pyrazoles; secondary carboxamide	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
bms-690514 [no description available]	2.15	1	0
bi 2536 [no description available]	2.15	1	0
inno-406 [no description available]	2.15	1	0	biaryl
Dihydrotanshinone I dihydrotanshinone I: extracted from Radix Salviae	3.51	1	0	abietane diterpenoid	anticoronaviral agent
kw 2449 KW 2449: has both multikinase inhibitory activity and antineoplastic activity; structure in first source	2.15	1	0
danusertib [no description available]	2.15	1	0	piperazines
abt 869 [no description available]	2.15	1	0	aromatic amine; indazoles; phenylureas	angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
azd 8931 sapitinib : A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoethyl]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.	2.15	1	0	aromatic ether; monochlorobenzenes; monofluorobenzenes; piperidines; quinazolines; secondary amino compound; tertiary amino compound	EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; epidermal growth factor receptor antagonist
arq 197 [no description available]	2.15	1	0	indoles
azd 1152 AZD-1152 : A member of the of quinazolines that is 4-aminoquinazolin-7-ol in which the amino group at position 4 has been substituted by a 5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl group, while the hydroxy group at position 7 has been converted into the corresponding 3-[ethyl(2-hydroxyethyl)aminopropyl ether.	2.15	1	0	anilide; monoalkyl phosphate; monofluorobenzenes; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; Aurora kinase inhibitor; prodrug
pf 00299804 dacomitinib: a pan-ERBB inhibitor. dacomitinib : A member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group.	10.06	20	2	enamide; monochlorobenzenes; monofluorobenzenes; piperidines; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
ridaforolimus [no description available]	2.15	1	0	macrolide lactam
ch 4987655 [no description available]	2.15	1	0
6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide [no description available]	2.15	1	0	phenylpyridine
sitagliptin phosphate Sitagliptin Phosphate: A pyrazine-derived DIPEPTIDYL-PEPTIDASE IV INHIBITOR and HYPOGLYCEMIC AGENT that increases the levels of the INCRETIN hormones GLUCAGON-LIKE PEPTIDE-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). It is used in the treatment of TYPE 2 DIABETES.	2.6	1	0
cc-930 [no description available]	2.15	1	0
tak 285 N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide: also inhibits HER2; structure in first source	2.59	2	0
idelalisib idelalisib: an antineoplastic agent and p110delta inhibitor; structure in first source. idelalisib : A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.	2.15	1	0	aromatic amine; organofluorine compound; purines; quinazolines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
crizotinib Crizotinib: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.. crizotinib : A 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that has R configuration at the chiral centre. The active enantiomer, it acts as a kinase inhibitor and is used for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)	6.64	32	0	3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine	antineoplastic agent; biomarker; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
osi 906 [no description available]	2.15	1	0	cyclobutanes; quinolines
chir-265 [no description available]	2.15	1	0	aromatic ether
motesanib [no description available]	2.15	1	0	pyridinecarboxamide
fostamatinib fostamatinib: a spleen tyrosine kinase (Syk) inhibitor, metabolized to R406	2.15	1	0
trametinib [no description available]	3.86	9	0	acetamides; aromatic amine; cyclopropanes; organofluorine compound; organoiodine compound; pyridopyrimidine; ring assembly	anticoronaviral agent; antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector
mln8054 [no description available]	2.15	1	0	benzazepine
pf-562,271 [no description available]	2.15	1	0	indoles
jnj-26483327 JNJ-26483327: an orally active macrocyclic tyrosine kinase inhibitor for treatment of patients with advanced solid tumours; in Phase I trial, 9/2010	2.15	1	0
ly2603618 [no description available]	2.15	1	0	ureas
tg100801 [no description available]	2.15	1	0
dactolisib dactolisib: antineoplastic agent that inhibits both phosphatidylinositol 3-kinase and mTOR. dactolisib : An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.	2.15	1	0	imidazoquinoline; nitrile; quinolines; ring assembly; ureas	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor
bgt226 BGT226 free base : An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 3-trifluoromethyl-4-(piperazin-1-yl)phenyl group and at position 8 by a 6-methoxypyridin-3-yl group. A dual PI3K/mTOR inhibitor.. BGT226 : The maleate salt of 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one. A dual PI3K/mTOR inhibitor.	2.15	1	0	aromatic ether; imidazoquinoline; N-arylpiperazine; organofluorine compound; pyridines	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor
brexpiprazole brexpiprazole: a serotonin agent; structure in first source	2.21	1	0	N-arylpiperazine
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	2.31	1	0
chidamide [no description available]	3.41	1	0	benzamides
gsk 461364 GSK 461364: an antineoplastic agent that inhibits polo-like kinase 1	2.66	2	0	(trifluoromethyl)benzenes
azd 1152-hqpa AZD2811: has antineoplastic activity; structure in first source	2.15	1	0	anilide; monofluorobenzenes; primary alcohol; pyrazoles; quinazolines; secondary amino compound; secondary carboxamide; tertiary amino compound	antineoplastic agent; Aurora kinase inhibitor
enmd 2076 ENMD 2076: an antiangiogenic agent with aurora kinase inhibitory and antineoplastic activities	2.15	1	0
e 7050 [no description available]	2.15	1	0	aromatic ether
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone [no description available]	2.15	1	0	pyrazolopyridine
tak-901 [no description available]	2.15	1	0
oligonucleotides [no description available]	2.15	1	0
vx-770 ivacaftor: a CFTR potentiator; structure in first source. ivacaftor : An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.	3.17	1	0	aromatic amide; monocarboxylic acid amide; phenols; quinolone	CFTR potentiator; orphan drug
gdc-0973 cobimetinib: has antineoplastic activity; structure in first source. cobimetinib : A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.	2.15	1	0	aromatic amine; difluorobenzene; N-acylazetidine; organoiodine compound; piperidines; secondary amino compound; tertiary alcohol	antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
buparlisib NVP-BKM120: a pan class I PI3 kinase inhibitor with antineoplastic activity; structure in first source	2.15	1	0	aminopyridine; aminopyrimidine; morpholines; organofluorine compound	antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
azd 1480 [no description available]	2.59	2	0
azd8330 [no description available]	2.15	1	0	pyridinecarboxamide
pha 848125 N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide: a cyclin dependent kinase inhibitor	2.15	1	0
ro5126766 RO5126766: a dual MEK/RAF kinase inhibitor. CH5126766 : A member of the class of coumarins that is 4-methyl-7-[(pyrimidin-2-yl)oxy]coumarin carrying an additional [2-[(methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl substituent at position 3.	3.73	2	0	aryloxypyrimidine; coumarins; organofluorine compound; pyridines; sulfamides	antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
fedratinib fedratinib: a selective small-molecule inhibitor of JAK2	2.15	1	0	sulfonamide
gsk690693 [no description available]	2.15	1	0	1,2,5-oxadiazole; acetylenic compound; aromatic amine; aromatic ether; imidazopyridine; piperidines; primary amino compound; tertiary alcohol	antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
ku 0063794 Ku 0063794: an mTOR inhibitor; structure in first source	2.25	1	0	benzyl alcohols; monomethoxybenzene; morpholines; pyridopyrimidine; tertiary amino compound	antineoplastic agent; mTOR inhibitor
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene: has antineoplastic activity; also inhibits Fms-like tyrosine kinase-3; structure in first source	2.15	1	0
azd5438 [no description available]	2.15	1	0	sulfonamide
pf 04217903 [no description available]	2.15	1	0	quinolines
gdc 0941 pictrelisib : A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.	4.78	4	0	indazoles; morpholines; piperazines; sulfonamide; thienopyrimidine	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
chitosan [no description available]	8.07	3	0
icotinib [no description available]	3.84	9	0
ph 797804 PH 797804: an NSAID; structure in first source. PH 797804 : A member of the class of benzamides obtained by formal condensation of the carboxy group of 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1-yl}-4-methylbenzoic acid with the amino group of methylamine.	2.15	1	0	aromatic ether; benzamides; organobromine compound; organofluorine compound; pyridone	anti-inflammatory agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
kx-01 [no description available]	2.15	1	0
thiostrepton Thiostrepton: One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.. thiostrepton : A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.	2.41	1	0
mk 5108 [no description available]	2.15	1	0	aromatic ether
cx 4945 [no description available]	3.73	2	0
cudc 101 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide: a histone deacetylase inhibitor; structure in first source	4.52	3	0
arry-614 pexmetinib: inhibits both p38 mitogen-activated protein kinase and Tie2 protein	2.15	1	0
tak 593 TAK 593: structure in first source	2.15	1	0
mln 8237 MLN 8237: an aurora kinase A inhibitor	2.15	1	0	benzazepine
sgx 523 [no description available]	2.15	1	0	aryl sulfide; biaryl; pyrazoles; quinolines; triazolopyridazine	c-Met tyrosine kinase inhibitor; nephrotoxic agent
bms 754807 BMS 754807: an IGR-1R kinase inhibitor; structure in first source	2.15	1	0	pyrazoles; pyridines; pyrrolidines; pyrrolotriazine	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
bms 777607 N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide: a Met kinase inhibitor; structure in first source	2.63	2	0	aromatic amide
sgi 1776 SGI 1776: a Pim kinase inhibitor; structure in first source	2.15	1	0	imidazoles
pci 32765 ibrutinib: a Btk protein inhibitor. ibrutinib : A member of the class of acrylamides that is (3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine in which the piperidine nitrogen is replaced by an acryloyl group. A selective and covalent inhibitor of the enzyme Bruton's tyrosine kinase, it is used for treatment of B-cell malignancies.	5.97	11	0	acrylamides; aromatic amine; aromatic ether; N-acylpiperidine; pyrazolopyrimidine; tertiary carboxamide	antineoplastic agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
ponatinib [no description available]	3.69	2	0	(trifluoromethyl)benzenes; acetylenic compound; benzamides; imidazopyridazine; N-methylpiperazine	antineoplastic agent; tyrosine kinase inhibitor
amg 900 N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine: a pan-aurora kinase inhibitor; structure in first source	2.15	1	0
mk-1775 adavosertib: a Wee1 kinase inhibitor; structure in first source	2.15	1	0	piperazines
AMG-208 [no description available]	2.15	1	0	aromatic ether; quinolines; triazolopyridazine	antineoplastic agent; c-Met tyrosine kinase inhibitor
quizartinib [no description available]	2.15	1	0	benzoimidazothiazole; isoxazoles; morpholines; phenylureas	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; necroptosis inhibitor
at13148 [no description available]	2.15	1	0
tak 733 [no description available]	2.15	1	0
mk 2206 MK 2206: a protein kinase inhibitor and antineoplastic agent	2.15	1	0	organic heterotricyclic compound	EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
navitoclax [no description available]	2.91	3	0	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
sns 314 SNS 314: an aurora kinase inhibitor; structure in first source	2.15	1	0	ureas
lucitanib E-3810: a multi-kinase inhibitor with antineoplastic activity; structure in first source. E-3810 : A hydrochloride salt obtained by reaction of 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-N-methyl-1-naphthamide with one equivalent of hydrochloric acid. E-3810 is a dual VEGFR and FGFR inhibitor. E-3810 free base : A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine.	2.15	1	0	aromatic ether; cyclopropanes; naphthalenecarboxamide; primary amino compound; quinolines	antineoplastic agent; fibroblast growth factor receptor antagonist; vascular endothelial growth factor receptor antagonist
pf-04691502 [no description available]	2.15	1	0
n-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide: a Janus kinase 1 and Janus kinase 2 inhibitor; structure in first source. momelotinib : A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.	2.15	1	0	aminopyrimidine; benzamides; morpholines; nitrile; secondary amino compound; tertiary amino compound	anti-anaemic agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
dcc-2036 rebastinib: an inhibitor of Tie2 tyrosine kinase receptor and antineoplastic agent	2.15	1	0	organofluorine compound; phenylureas; pyrazoles; pyridinecarboxamide; quinolines	tyrosine kinase inhibitor
cabozantinib cabozantinib: a multikinase inhibitor. cabozantinib : A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.	3.16	4	0	aromatic ether; dicarboxylic acid diamide; organofluorine compound; quinolines	antineoplastic agent; tyrosine kinase inhibitor
defactinib [no description available]	2.15	1	0
ly2584702 [no description available]	2.15	1	0
incb-018424 [no description available]	2.85	3	0	nitrile; pyrazoles; pyrrolopyrimidine	antineoplastic agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
poziotinib HM781-36B: antitumor irreversible Pan-HER inhibitor for treatment of gastric cancer	8.47	6	0	acrylamides; aromatic ether; dichlorobenzene; diether; monofluorobenzenes; N-acylpiperidine; quinazolines; secondary amino compound; substituted aniline	antineoplastic agent; apoptosis inducer; epidermal growth factor receptor antagonist
asp3026 ASP3026: an anaplastic lymphoma receptor tyrosine kinase inhibitor; structure in first source. ASP-3026 : A member of the class of diamino-1,3,5-triazines that is 1,3,5-triazine-2,4-diamine in which the amino groups at positions 2 and 4 are respectively carrying 2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl and 2-(propan-2-ylsulfonyl)phenyl substituents. It is a potent inhibitor of anaplastic lymphoma kinase (ALK), Ack and ROS1 activity (IC50 values are 3.5, 5.8 and 8.9 nM respectively) and exhibits anti-cancer properties.	2.15	1	0	aromatic amine; diamino-1,3,5-triazine; monomethoxybenzene; N-methylpiperazine; piperidines; secondary amino compound; sulfone	antimalarial; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 6.1.1.6 (lysine--tRNA ligase) inhibitor
entrectinib entrectinib: inhibits TRK, ROS1, and ALK receptor tyrosine kinases; structure in first source. entrectinib : A member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours.	2.15	1	0	benzamides; difluorobenzene; indazoles; N-methylpiperazine; oxanes; secondary amino compound; secondary carboxamide	antibacterial agent; antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
pexidartinib pexidartinib: inhibits both CSF1R and c-kit receptor tyrosine kinase; structure in first source. pexidartinib : A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).	2.15	1	0	aminopyridine; organochlorine compound; organofluorine compound; pyrrolopyridine; secondary amino compound	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
cobicistat [no description available]	6.15	2	2	1,3-thiazoles; carbamate ester; monocarboxylic acid amide; morpholines; ureas	P450 inhibitor
TAK-580 MLN 2480: brain-penetrant RAF dimer antagonist. TAK-580 : A 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults.	2.15	1	0	1,3-thiazolecarboxamide; aminopyrimidine; chloropyridine; organofluorine compound; pyrimidinecarboxamide; secondary carboxamide	antineoplastic agent; apoptosis inducer; B-Raf inhibitor
gsk 2126458 omipalisib: inhibitor of mTOR protein. omipalisib : A member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors.	3.73	2	0	aromatic ether; difluorobenzene; pyridazines; pyridines; quinolines; sulfonamide	anticoronaviral agent; antineoplastic agent; autophagy inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor; radiosensitizing agent
emd1214063 tepotinib: MET inhibitor	2.15	1	0
pf 3758309 PF 3758309: a PAK4 p21-activated kinase inhibitor; structure in first source	2.15	1	0	organic heterobicyclic compound; organonitrogen heterocyclic compound; organosulfur heterocyclic compound
gdc 0980 [no description available]	2.15	1	0
azd2014 vistusertib: potent and selective dual mTORC1 and mTORC2 inhibitor; structure in first source	2.15	1	0
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol: a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity; structure in first source	2.15	1	0	benzyl alcohols; morpholines; pyridopyrimidine; tertiary amino compound	antineoplastic agent; apoptosis inducer; mTOR inhibitor
plx4032 [no description available]	3.18	4	0	aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide	antineoplastic agent; B-Raf inhibitor
gsk 1363089 GSK 1363089: a multikinase inhibitor that acts on Met, RON, Axl, and VEGFR; structure in first source	2.15	1	0	aromatic ether
arry-334543 ARRY-334543: an antagonist of ATP-binding cassette subfamily G member 2 (ABCG2); structure in first source	2.15	1	0
kin-193 [no description available]	2.15	1	0	pyridopyrimidine
mk 2461 [no description available]	2.15	1	0
bay 869766 [no description available]	2.15	1	0
as 703026 [no description available]	2.15	1	0	pyridinecarboxamide
baricitinib [no description available]	3.73	2	0	azetidines; nitrile; pyrazoles; pyrrolopyrimidine; sulfonamide	anti-inflammatory agent; antirheumatic drug; antiviral agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; immunosuppressive agent
piperidines Piperidines: A family of hexahydropyridines.	6.02	16	0
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.72	2	0
dabrafenib [no description available]	3.31	5	0	1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide	anticoronaviral agent; antineoplastic agent; B-Raf inhibitor
pki 587 gedatolisib: inhibits both phosphatidylinositol 3-kinase and mTOR; structure in first source	2.15	1	0
n-(3-fluoro-4-((1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5 yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide merestinib: in phase I clinical trials (2013); structure in first source	2.15	1	0
thiopental sodium [no description available]	5.21	13	0	organochlorine compound; piperazines; pyrimidines	antineoplastic agent; tyrosine kinase inhibitor
ribociclib ribociclib: inhibits both CDK4 and CDK6	2.15	1	0
apatinib apatinib: reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters; structure in first source	2.72	2	0
mk-8033 1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide: inhibits both Ron and c-Met kinases; structure in first source	2.15	1	0
5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine sapanisertib: an mTOR inhibitor	2.25	1	0	benzoxazole
pha 793887 [no description available]	2.15	1	0	piperidinecarboxamide
nps-1034 NPS-1034: a protein kinase inhibitor that acts on MET and AXL; structure in first source	2.21	1	0
sb 1518 [no description available]	2.15	1	0
abemaciclib [no description available]	5.91	5	0
mk-8776 [no description available]	2.15	1	0
afuresertib [no description available]	2.15	1	0	amphetamines
arry-371797 ARRY-371797: a p38 MAP kinase inhibitor	3.51	1	0
gsk 1070916 GSK 1070916: an antineoplastic agent with aurora B/C kinase inhibitory activity	2.15	1	0	pyrazoles; ring assembly
jq1 compound [no description available]	3.35	1	0	carboxylic ester; organochlorine compound; tert-butyl ester; thienotriazolodiazepine	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; bromodomain-containing protein 4 inhibitor; cardioprotective agent; ferroptosis inducer
jnj38877605 [no description available]	2.15	1	0	quinolines
dinaciclib [no description available]	3.73	2	0	pyrazolopyrimidine
gilteritinib gilteritinib: an FLT3/AXL protein tyrosine kinase inhibitor. gilteritinib : A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation.	4.94	3	0	aromatic amine; monomethoxybenzene; N-methylpiperazine; oxanes; piperidines; primary carboxamide; pyrazines; secondary amino compound	antineoplastic agent; apoptosis inducer; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
alectinib [no description available]	5.81	13	0	aromatic ketone; morpholines; nitrile; organic heterotetracyclic compound; piperidines	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
glpg0634 [no description available]	2.15	1	0
lusutrombopag lusutrombopag: a thrombopoietin receptor agonist; structure in first source	3.17	1	0	cinnamic acids
abt-199 venetoclax: A BCL-2 inhibitor with antineoplastic activity that is used in the treatment of CHRONIC LYMPHOCYTIC LEUKEMIA associated with chromosome 17p deletion; structure in first source.. venetoclax : A member of the class of pyrrolopyridines that is a potent inhibitor of the antiapoptotic protein B-cell lymphoma 2. It is used for treamtment of chronic lymphocytic leukemia with 17p deletion.	2.82	2	0	aromatic ether; C-nitro compound; monochlorobenzenes; N-alkylpiperazine; N-arylpiperazine; N-sulfonylcarboxamide; oxanes; pyrrolopyridine	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor
encorafenib encorafenib: a BRAF inhibitor	2.15	1	0
bms-911543 N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo(4,5-d)pyrrolo(2,3b)pyridine-7-carboxamide: has antineoplastic activity; structure in first source	2.15	1	0
azd4547 [no description available]	2.21	1	0	benzamides; N-arylpiperazine; pyrazoles	fibroblast growth factor receptor antagonist
gsk2141795 GSK2141795: an Akt inhibitor with antineoplastic activity; structure in first source	2.15	1	0
azd8186 [no description available]	2.15	1	0
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea infigratinib: structure in first source. BGJ-398 : A member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor.	2.21	1	0	aminopyrimidine; dichlorobenzene; N-alkylpiperazine; N-arylpiperazine; phenylureas	antineoplastic agent; fibroblast growth factor receptor antagonist
acy-1215 ricolinostat: an HDAC6 inhibitor; structure in first source	3.41	1	0	pyrimidinecarboxylic acid
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	2.31	1	0
cudc-907 [no description available]	3.35	1	0
byl719 [no description available]	2.15	1	0	proline derivative
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	7.82	2	0
transforming growth factor beta Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.	2.31	1	0
cep-32496 agerafenib: inhibitor of RAF family kinases; structure in first source	2.15	1	0
rociletinib rociletinib: inhibits epidermal growth factor receptor tyrosine kinase activity; structure in first source	10.12	27	1
ceritinib ceritinib: an anaplastic lymphoma kinase inhibitor. ceritinib : A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.	11.59	8	0	aminopyrimidine; aromatic ether; organochlorine compound; piperidines; secondary amino compound; sulfone	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
azd1208 [no description available]	2.15	1	0
vx-509 [no description available]	2.53	2	0
debio 1347 CH5183284: a fibroblast growth factor receptor antagonist; structure in first source	2.15	1	0
erdafitinib erdafitinib: inhibitor of fibroblast growth factor receptors	7.25	1	0
gsk-2816126 GSK-2816126: inhibits EZH2 methyltransferase; structure in first source	3.51	1	0	piperazines; pyridines
volitinib [no description available]	2.15	1	0
acp-196 acalabrutinib: inhibits Bruton’s tyrosine kinase; has antineoplastic activity. acalabrutinib : A member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.	4.43	2	0	aromatic amine; benzamides; imidazopyrazine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; ynone	antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
ly3009120 LY3009120: a pan-RAF inhibitor; structure in first source. LY3009120 : A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.	2.6	1	0	aminotoluene; aromatic amine; biaryl; monofluorobenzenes; phenylureas; pyridopyrimidine; secondary amino compound	antineoplastic agent; apoptosis inducer; autophagy inducer; B-Raf inhibitor; necroptosis inhibitor
pf-06463922 lorlatinib: inhibits both anaplastic lymphoma kinase and c-ros oncogene 1 (ROS1) protein. lorlatinib : A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.	4.27	4	0	aminopyridine; aromatic ether; azamacrocycle; benzamides; cyclic ether; monofluorobenzenes; nitrile; organic heterotetracyclic compound; pyrazoles	antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.6	1	0
azd3759 [no description available]	2.69	2	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone: an interleukin-1beta converting enzyme (ICE)-like protease inhibitor	2.13	1	0
s 8932 [no description available]	3.17	1	0	aromatic amine; C-nucleoside; carboxylic ester; nitrile; phosphoramidate ester; pyrrolotriazine	anticoronaviral agent; antiviral drug; prodrug
cyclosporine Cyclosporine: A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).	2.41	1	0
protac-3 [no description available]	2.72	2	0
at 9283 [no description available]	2.15	1	0
otssp167 OTS167: inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity	2.15	1	0
chir 258 [no description available]	2.15	1	0
osi 027 OSI 027: inhibits both mTORC1 and mTORC2; structure in first source	2.15	1	0
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.17	1	0	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
pemetrexed pemetrexed disodium : An organic sodium salt that is the disodium salt of N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).	14.98	38	25	N-acyl-L-glutamic acid; pyrrolopyrimidine	antimetabolite; antineoplastic agent; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; EC 2.1.1.45 (thymidylate synthase) inhibitor; EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor
nintedanib nintedanib : A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.	2.88	3	0
amg531 [no description available]	3.17	1	0
bay 80-6946 copanlisib: an antineoplastic agent with PI3K inhibitory activity; structure in first source. copanlisib : An imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies.	2.15	1	0
pp242 torkinib : A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.	2.25	1	0	aromatic amine; biaryl; hydroxyindoles; phenols; primary amino compound; pyrazolopyrimidine	antineoplastic agent; mTOR inhibitor
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	3.78	8	0

Condition	Indicated	Relationship Strength	Studies	Trials
Carcinoma, Non-Small Cell Lung [description not available]	0	27.99	1,403	521
Cancer of Lung [description not available]	0	28.25	1,629	532
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	1	29.99	1,403	521
Lung Neoplasms Tumors or cancer of the LUNG.	1	33.02	3,258	1,064
Benign Neoplasms [description not available]	0	9.61	16	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1	14.07	32	4
Experimental Neoplasms [description not available]	0	3.43	6	0
Acute Myelogenous Leukemia [description not available]	0	2.15	1	0
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	0	2.15	1	0
Adverse Drug Event [description not available]	0	6.44	17	2
Drug-Related Side Effects and Adverse Reactions Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.	0	6.44	17	2
Infections, Coronavirus [description not available]	0	3.86	3	0
2019 Novel Coronavirus Disease [description not available]	0	6.8	6	1
Pneumonia, Viral Inflammation of the lung parenchyma that is caused by a viral infection.	0	3.86	3	0
Coronavirus Infections Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).	0	3.86	3	0
Breast Cancer [description not available]	0	2.76	2	0
Breast Neoplasms Tumors or cancer of the human BREAST.	0	2.76	2	0
Congenital Zika Syndrome [description not available]	0	2.25	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	8.87	43	0
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	0	2.25	1	0
Benign Meningeal Neoplasms [description not available]	0	5.69	9	0
Metastase [description not available]	0	17.77	30	10
Meningeal Neoplasms Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.	0	5.69	9	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	0	12.77	30	10
Erythrocytosis [description not available]	0	7.31	1	0
Blood Clot [description not available]	0	2.31	1	0
Thrombosis Formation and development of a thrombus or blood clot in the blood vessel.	0	7.31	1	0
Astrocytoma, Grade IV [description not available]	0	5.58	9	0
Local Neoplasm Recurrence [description not available]	0	15.64	73	24
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	1	7.58	9	0
Lung Adenocarcinoma [description not available]	0	15.33	145	10
Cancer of Cervix [description not available]	0	2.31	1	0
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	1	17.33	145	10
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	0	2.31	1	0
Carcinoma, Neuroendocrine A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round blue cells, granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (oat) cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)	0	4.28	5	0
Acute Kidney Failure [description not available]	0	2.41	1	0
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	0	2.41	1	0
Diffuse Parenchymal Lung Disease [description not available]	0	8.96	30	1
Lung Diseases, Interstitial A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.	0	8.96	30	1
Disease Exacerbation [description not available]	0	15.4	76	13
Cancer of the Ureter [description not available]	0	3.23	1	0
Ureteral Neoplasms Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.	0	3.23	1	0
Carcinoma, Anaplastic [description not available]	0	2.76	2	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1	4.76	2	0
Benign Neoplasms, Brain [description not available]	0	17.98	109	48
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	1	19.98	109	48
Minimal Disease, Residual [description not available]	0	2.31	1	0
Adenocarcinoma, Basal Cell [description not available]	0	8.86	45	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1	10.86	45	1
Carcinomatous Meningitis [description not available]	0	15.23	31	5
Meningeal Carcinomatosis Primary or secondary neoplasm in the ARACHNOID or SUBARACHNOID SPACE. It appears as a diffuse fibrotic thickening of the MENINGES associated with variable degrees of inflammation.	0	10.23	31	5
Central Nervous System Neoplasm [description not available]	0	12.18	17	11
Central Nervous System Neoplasms Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.	0	12.18	17	11
Thromboembolism, Venous [description not available]	0	2.82	2	0
Venous Thromboembolism Obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream.	0	7.82	2	0
Carcinoma, Small Cell Lung [description not available]	0	7.28	11	1
Small Cell Lung Carcinoma A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).	0	7.28	11	1
Cardiac Toxicity [description not available]	0	4.07	9	0
Diabetes Mellitus, Adult-Onset [description not available]	0	2.41	1	0
Cardiac Failure [description not available]	0	5.54	11	0
Electrocardiogram QT Prolonged [description not available]	0	3.57	2	0
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	0	2.41	1	0
Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	0	5.54	11	0
Long QT Syndrome A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.	0	3.57	2	0
Cardiotoxicity Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	0	4.07	9	0
Pleural Effusion Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.	0	3.55	6	0
Hives [description not available]	0	2.41	1	0
Urticaria A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.	0	7.41	1	0
Chronic Hepatitis B [description not available]	0	7.41	1	0
Acute Yellow Atrophy [description not available]	0	2.41	1	0
Hepatitis B, Chronic INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	0	2.41	1	0
Antidiuretic Hormone, Inappropriate Secretion [description not available]	0	2.76	2	0
Hyponatremia Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)	0	2.72	2	0
Inappropriate ADH Syndrome A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.	0	2.76	2	0
Hypermelanosis [description not available]	0	2.41	1	0
Hyperpigmentation Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.	0	7.41	1	0
Petechiae Pinhead size (3 mm) skin discolorization due to hemorrhage.	0	2.41	1	0
Incontinentia Pigmenti Achromians [description not available]	0	2.41	1	0
Purpura Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is	0	2.41	1	0
Carcinoma, Epidermoid [description not available]	0	11.25	20	4
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1	13.25	20	4
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	0	5.19	13	0
Pneumonia Infection of the lung often accompanied by inflammation.	0	10.19	13	0
Carcinoma, Oat Cell [description not available]	0	2.41	1	0
Pleural Effusion, Malignant Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.	0	5.41	6	2
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	0	2.41	1	0
Cancer of Liver [description not available]	0	5.19	8	1
Liver Neoplasms Tumors or cancer of the LIVER.	0	5.19	8	1
Colorectal Cancer [description not available]	0	8.01	3	0
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	1	5.01	3	0
Autoimmune Disease [description not available]	0	2.6	1	0
Alveolar Proteinoses, Pulmonary [description not available]	0	2.6	1	0
Autoimmune Diseases Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	0	2.6	1	0
Pulmonary Alveolar Proteinosis A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.	0	7.6	1	0
Chromosome Shattering [description not available]	0	2.41	1	0
Eosinophilia, Pulmonary [description not available]	0	2.63	2	0
Pulmonary Eosinophilia A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.	0	2.63	2	0
Anoxemia [description not available]	0	2.9	2	0
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	0	2.9	2	0
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	0	7.41	1	0
Abscess, Pulmonary [description not available]	0	2.41	1	0
Lung Abscess Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.	0	7.41	1	0
Nasopharyngeal Carcinoma A carcinoma that originates in the EPITHELIUM of the NASOPHARYNX and includes four subtypes: keratinizing squamous cell, non-keratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations associated with this cancer have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes.	0	2.41	1	0
Cancer of Nasopharynx [description not available]	0	2.41	1	0
Nasopharyngeal Neoplasms Tumors or cancer of the NASOPHARYNX.	0	2.41	1	0
Thrombopenia [description not available]	0	3.01	2	0
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	0	3.01	2	0
Paronychia An inflammatory reaction involving the folds of the skin surrounding the fingernail. It is characterized by acute or chronic purulent, tender, and painful swellings of the tissues around the nail, caused by an abscess of the nail fold. The pathogenic yeast causing paronychia is most frequently Candida albicans. Saprophytic fungi may also be involved. The causative bacteria are usually Staphylococcus, Pseudomonas aeruginosa, or Streptococcus. (Andrews' Diseases of the Skin, 8th ed, p271)	0	4.11	2	1
Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	0	7.6	6	3
Glial Cell Tumors [description not available]	0	2.6	1	0
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	0	2.6	1	0
Carcinoma, Adenosquamous A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.	0	3.17	4	0
Hepatocellular Carcinoma [description not available]	0	7.6	1	0
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	0	2.6	1	0
Hematochezia The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.	0	2.6	1	0
Gastrointestinal Hemorrhage Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.	0	2.6	1	0
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	0	3.64	7	0
Injuries, Spinal Cord [description not available]	0	2.6	1	0
Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).	0	2.6	1	0
Bone Cancer [description not available]	0	4.43	6	0
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	0	4.43	6	0
Bone Diseases Diseases of BONES.	0	3.52	1	0
Recrudescence [description not available]	0	3.54	6	0
Kidney Failure A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.	0	2.25	1	0
Renal Insufficiency Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.	0	2.25	1	0
Fibrosis, Radiation [description not available]	0	2.63	2	0
Radiation Pneumonitis Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.	0	7.63	2	0
Angiitis [description not available]	0	2.21	1	0
Vasculitis Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.	0	7.21	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	5.81	10	0
Innate Inflammatory Response [description not available]	0	2.21	1	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.21	1	0
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	0	2.21	1	0
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	0	2.21	1	0
Corneal Diseases Diseases of the cornea.	0	2.57	2	0
Day Blindness [description not available]	0	2.66	2	0
Carcinoma, Large Cell A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)	0	2.9	3	0
Elevated ICP (Intracranial Pressure) [description not available]	0	2.25	1	0
Constriction, Pathological [description not available]	0	2.25	1	0
Bilateral Headache [description not available]	0	2.25	1	0
Constriction, Pathologic The condition of an anatomical structure's being constricted beyond normal dimensions.	0	2.25	1	0
Headache The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.	0	2.25	1	0
Intracranial Hypertension Increased pressure within the cranial vault. This may result from several conditions, including HYDROCEPHALUS; BRAIN EDEMA; intracranial masses; severe systemic HYPERTENSION; PSEUDOTUMOR CEREBRI; and other disorders.	0	2.25	1	0
Acute Liver Injury, Drug-Induced [description not available]	0	4.26	3	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	0	4.26	3	1
Anemia, Hypoplastic [description not available]	0	2.59	2	0
Anemia, Aplastic A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.	0	2.59	2	0
Hepatitis B Virus Infection [description not available]	0	7.25	1	0
Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	0	7.25	1	0
Ventricular Fibrillation A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.	0	7.25	1	0
Delirium of Mixed Origin [description not available]	0	2.25	1	0
Delirium A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)	0	2.25	1	0
Uveitis, Anterior Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.	0	2.31	1	0
Hepatic Insufficiency Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.	0	4.55	1	1
Li-Fraumeni Syndrome Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.	0	2.25	1	0
Torsade de Pointes [description not available]	0	2.25	1	0
Invasiveness, Neoplasm [description not available]	0	3.31	5	0
Cells, Neoplasm Circulating [description not available]	0	2.69	2	0
Drug-Induced Stevens Johnson Syndrome [description not available]	0	3.82	3	0
Stevens-Johnson Syndrome Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.	0	8.82	3	0
Dermatomyositis, Adult Type [description not available]	0	2.25	1	0
Dermatomyositis A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)	0	7.25	1	0
Carcinoma, Bronchial [description not available]	0	2.31	1	0
Exanthem [description not available]	0	4.31	3	1
Carcinoma, Bronchogenic Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.	0	2.31	1	0
Exanthema Diseases in which skin eruptions or rashes are a prominent manifestation. Classically, six such diseases were described with similar rashes; they were numbered in the order in which they were reported. Only the fourth (Duke's disease), fifth (ERYTHEMA INFECTIOSUM), and sixth (EXANTHEMA SUBITUM) numeric designations survive as occasional synonyms in current terminology.	0	4.31	3	1
Lymph Node Metastasis [description not available]	0	11.5	16	16
Adenopathy [description not available]	0	7.25	1	0
Cardiomyopathies, Primary [description not available]	0	2.25	1	0
Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).	0	2.25	1	0
Response Evaluation Criteria in Solid Tumors An internationally recognized set of published rules used for evaluation of cancer treatment that define when tumors found in cancer patients improve, worsen, or remain stable during treatment. These criteria are based specifically on the response of the tumor(s) to treatment, and not on the overall health status of the patient resulting from treatment.	0	5.76	3	2
Cancer of the Uterus [description not available]	0	2.25	1	0
Uterine Neoplasms Tumors or cancer of the UTERUS.	0	2.25	1	0
Adenoma, Basal Cell [description not available]	0	2.31	1	0
Cancer of Pituitary [description not available]	0	2.31	1	0
Adenoma A benign epithelial tumor with a glandular organization.	0	2.31	1	0
Pituitary Neoplasms Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.	0	2.31	1	0
Acute Symptom Flare [description not available]	0	2.31	1	0
Idiopathic Inflammatory Myopathies [description not available]	0	3.84	3	0
Myositis Inflammation of a muscle or muscle tissue.	0	3.84	3	0
Cardiac Diseases [description not available]	0	3.01	3	0
Heart Diseases Pathological conditions involving the HEART including its structural and functional abnormalities.	0	3.01	3	0
Iris Neoplasms Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.	0	2.25	1	0
Mucositis, Oral [description not available]	0	2.31	1	0
Stomatitis INFLAMMATION of the soft tissues of the MOUTH, such as MUCOSA; PALATE; GINGIVA; and LIP.	0	7.31	1	0
Angiogenesis, Pathologic [description not available]	0	2.66	2	0
Chronic Lung Injury [description not available]	0	3.23	1	0
Dermatitis Medicamentosa [description not available]	0	5.18	3	1
Pulmonary Consumption [description not available]	0	2.31	1	0
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	0	2.31	1	0
Micrometastases, Neoplasm [description not available]	0	2.31	1	0
Malnourishment [description not available]	0	2.41	1	0
Dysphagia [description not available]	0	2.41	1	0
Esophageal Stricture [description not available]	0	7.41	1	0
Deglutition Disorders Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.	0	2.41	1	0
Esophageal Stenosis A stricture of the ESOPHAGUS. Most are acquired but can be congenital.	0	2.41	1	0
Malnutrition An imbalanced nutritional status resulting from insufficient intake of nutrients to meet normal physiological requirement.	0	2.41	1	0
Acute Hypercapnic Respiratory Failure [description not available]	0	2.41	1	0
Respiratory Insufficiency Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)	0	2.41	1	0
Colitis Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.	0	7.15	1	0
Chronic Kidney Failure [description not available]	0	2.15	1	0
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	0	2.15	1	0
Breathlessness [description not available]	0	2.15	1	0
Dyspnea Difficult or labored breathing.	0	2.15	1	0
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	0	2.57	2	0
Multiple Pulmonary Nodules A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.	0	2.58	2	0
Choroid Neoplasms Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).	0	2.17	1	0
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	0	6.04	5	1
Genetic Predisposition [description not available]	0	3.5	2	0
Chronic Kidney Diseases [description not available]	0	2.17	1	0
Renal Insufficiency, Chronic Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)	0	2.17	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	3.95	2	1
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	0	4.48	1	1
Pyrexia [description not available]	0	2.17	1	0
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	0	7.17	1	0
Lassitude [description not available]	0	3.56	1	1
Emesis [description not available]	0	3.56	1	1
Fatigue The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.	0	3.56	1	1
Nausea An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.	0	3.56	1	1
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	0	3.56	1	1
Ulcer A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.	0	2.21	1	0
Asthma, Bronchial [description not available]	0	2.21	1	0
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	0	2.21	1	0
Adenoma, Pleomorphic A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)	0	2.21	1	0
Pneumatosis Cystoides Intestinalis A condition characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the INTESTINE. The majority of the cysts are found in the JEJUNUM and the ILEUM.	0	2.21	1	0
Chylopericardium [description not available]	0	3.59	1	1
Pericardial Effusion Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.	0	8.59	1	1
Jaw Diseases Diseases involving the JAW.	0	2.61	2	0
Aseptic Necrosis of Bone [description not available]	0	2.61	2	0
Osteonecrosis Death of a bone or part of a bone, either atraumatic or posttraumatic.	0	2.61	2	0
Erythema Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	0	7.21	1	0
Intradural-Extramedullary Spinal Cord Neoplasms [description not available]	0	2.21	1	0
Spinal Cord Neoplasms Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.	0	2.21	1	0
Neoplasms, Pleural [description not available]	0	2.13	1	0

osimertinib

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Overview

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Treatment

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Pharmacokinetics

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Dosage Studied

Roles (2)

Drug Classes (9)

Pathways (5)

Protein Targets (322)

Potency Measurements

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Biological Processes (2531)

Molecular Functions (540)

Ceullar Components (414)

Bioassays (1179)

Research

Studies (1,296)

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Research Demand Index: 88.27

Study Types

osimertinib

Description

Cross-References

Synonyms (70)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Pharmacokinetics

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (2)

Drug Classes (9)

Pathways (5)

Protein Targets (322)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements

Biological Processes (2531)

Molecular Functions (540)

Ceullar Components (414)

Bioassays (1179)

Research

Studies (1,296)

Market Indicators

Research Demand Index: 88.27

Study Types

Related Drugs (449)

Related Conditions (234)