Page last updated: 2024-08-01 20:05:20
cgp 48664
Description
4-amidinoindan-1-one 2'-amidinohydrazone: structure given in first source [MeSH]
Cross-References
ID Source | ID |
PubMed CID | 9576789 |
CHEMBL ID | 1202793 |
CHEMBL ID | 65789 |
SCHEMBL ID | 19379381 |
MeSH ID | M0219593 |
Synonyms (31)
Synonym |
sardomozide chloride |
CHEMBL1202793 , |
4-amidinoindan-1-one-2'-amidinohydrazone |
4-aiah |
hydrazinecarboximidamide, 2-(4-(aminoiminomethyl)-2,3-dihydro-1h-inden-1-ylidene)- |
cgp 48664 |
sam 486a |
sam486a |
(1e)-1-(carbamimidoylhydrazono)indane-4-carboxamidine |
cgp-48664 |
cgp-48664a |
urea azine with 1-oxo-4-indancarboxamidine |
4-amidinoindan-1-one 2'-amidinohydrazone |
CHEMBL65789 |
AKOS016004846 |
AKOS016000728 |
bdbm50368644 |
unii-ceb05s0b9i |
ceb05s0b9i , |
sardomozide [inn] |
4-(aminoiminomethyl)-2,3-dihydro-1h-inden-1-one-diaminomethylenehydrazone |
(e)-2-(4-carbamimidoyl-2,3-dihydro-1h-inden-1-ylidene)hydrazinecarboximidamide |
(e)-1-((diaminomethylene)hydrazono)-2,3-dihydro-1h-indene-4-carboximidamide |
(2e)-2-(4-carbamimidoyl-2,3-dihydro-1h-inden-1-ylidene)hydrazinecarboximidamide |
SCHEMBL19379381 |
HY-13746 |
CS-0007772 |
(1e)-1-(diaminomethylidenehydrazinylidene)-2,3-dihydroindene-4-carboximidamide |
4-amidinoindan-1-one 2/'-amidinohydrazone |
A926062 |
AKOS040737423 |
Research
Studies (51)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 27 (52.94) | 18.2507 |
2000's | 22 (43.14) | 29.6817 |
2010's | 1 (1.96) | 24.3611 |
2020's | 1 (1.96) | 2.80 |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 7 (13.46%) | 5.53% |
Reviews | 1 (1.92%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 44 (84.62%) | 84.16% |
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:4, 2005
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.International journal of oncology, , Volume: 25, Issue:6, 2004
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.Journal of molecular endocrinology, , Volume: 22, Issue:2, 1999
Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells.Breast cancer research and treatment, , Volume: 39, Issue:3, 1996
Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture.International journal of cancer, , Aug-09, Volume: 62, Issue:4, 1995
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 8, Issue:7, 2002
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 6, Issue:5, 2000
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Observations with an S-adenosylmethionine decarboxylase inhibitor in rats with prostatic adenocarcinoma.Arzneimittel-Forschung, , Volume: 46, Issue:3, 1996
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.Melanoma research, , Volume: 5, Issue:3, 1995
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma.Investigational new drugs, , Volume: 23, Issue:3, 2005
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.Melanoma research, , Volume: 5, Issue:3, 1995
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.Cancer research, , Nov-15, Volume: 54, Issue:22, 1994
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma.Investigational new drugs, , Volume: 23, Issue:3, 2005
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, , Mar-15, Volume: 10, Issue:6, 2004
The role of polyamines in human cancer: prospects for drug combination therapies.Hawaii medical journal, , Volume: 63, Issue:12, 2004
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 8, Issue:7, 2002
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers.Journal of clinical pharmacology, , Volume: 40, Issue:3, 2000
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 6, Issue:5, 2000
A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.British journal of cancer, , Volume: 83, Issue:5, 2000
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.Molecular cancer therapeutics, , Volume: 8, Issue:7, 2009
Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells.Oncogene, , Aug-25, Volume: 24, Issue:36, 2005
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:4, 2005
Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.International journal of oncology, , Volume: 25, Issue:6, 2004
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.Journal of molecular endocrinology, , Volume: 22, Issue:2, 1999
Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells.Breast cancer research and treatment, , Volume: 39, Issue:3, 1996
Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture.International journal of cancer, , Aug-09, Volume: 62, Issue:4, 1995
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 8, Issue:7, 2002
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 6, Issue:5, 2000
In vivo manipulation of L1210 cell cycle phase distribution with alpha-difluoromethylornithine, 4-amidinoindan-1-one 2'-amidinohydrazone and N1-acetylspermine.Biochimica et biophysica acta, , Jun-05, Volume: 1381, Issue:1, 1998
In vitro manipulation of L1210 cell cycle kinetics with 4-amidinoindan-1-one 2'-amidinohydrazone, alpha-difluoromethylornithine and N1-acetylspermine.Biochimica et biophysica acta, , Jun-05, Volume: 1381, Issue:1, 1998
4-Amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition.Biochimica et biophysica acta, , Apr-17, Volume: 1335, Issue:1-2, 1997
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme.The Biochemical journal, , Feb-15, Volume: 322 ( Pt 1), 1997
In vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) and alpha-difluoromethylornithine (DFMO) on L1210 growth, cell-cycle phase distribution and polyamine contents.International journal of cancer, , Sep-15, Volume: 62, Issue:6, 1995
In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.International journal of cancer, , Apr-10, Volume: 61, Issue:2, 1995
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.Cancer research, , Jun-15, Volume: 54, Issue:12, 1994
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Observations with an S-adenosylmethionine decarboxylase inhibitor in rats with prostatic adenocarcinoma.Arzneimittel-Forschung, , Volume: 46, Issue:3, 1996
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.Melanoma research, , Volume: 5, Issue:3, 1995
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma.Investigational new drugs, , Volume: 23, Issue:3, 2005
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.Melanoma research, , Volume: 5, Issue:3, 1995
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.Cancer research, , Nov-15, Volume: 54, Issue:22, 1994
Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.Carcinogenesis, , 04-22, Volume: 41, Issue:2, 2020
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:4, 2005
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.International journal of oncology, , Volume: 25, Issue:6, 2004
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.Clinical & experimental metastasis, , Volume: 22, Issue:3, 2005
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma.Investigational new drugs, , Volume: 23, Issue:3, 2005
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, , Mar-15, Volume: 10, Issue:6, 2004
The role of polyamines in human cancer: prospects for drug combination therapies.Hawaii medical journal, , Volume: 63, Issue:12, 2004
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 8, Issue:7, 2002
A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.British journal of cancer, , Volume: 83, Issue:5, 2000
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers.Journal of clinical pharmacology, , Volume: 40, Issue:3, 2000
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group.Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 6, Issue:5, 2000
Safety/Toxicity (1)
Pharmacokinetics (3)
Article | Year |
Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, , Mar-15, Volume: 10, Issue:6 | 2004 |
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 8, Issue:7 | 2002 |
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers. Journal of clinical pharmacology, , Volume: 40, Issue:3 | 2000 |
Dosage (3)
Article | Year |
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. Clinical & experimental metastasis, , Volume: 22, Issue:4 | 2005 |
Phase I and pharmacological study of weekly administration of the polyamine synthesis inhibitor SAM 486A (CGP 48 664) in patients with solid tumors. European Organization for Research and Treatment of Cancer Early Clinical Studies Group. Clinical cancer research : an official journal of the American Association for Cancer Research, , Volume: 6, Issue:5 | 2000 |
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. Cancer research, , Nov-15, Volume: 54, Issue:22 | 1994 |
Interactions (2)