aspartic acid has been researched along with Fatigue in 46 studies
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent
L-aspartic acid : The L-enantiomer of aspartic acid.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared to healthy controls, the RRMS group showed significantly higher fatigue and lower metabolic ratios for tyrosine, glutathione, homocarnosine (GSH+Hca), fucose-3, glutamine+glutamate (Glx), glycerophosphocholine (GPC), total choline, and N-acetylaspartate (NAA-2), while increased levels for isoleucine and glucose (P ≤ ." | 4.02 | Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy. ( Al-Iedani, O; Arm, J; Lea, R; Lechner-Scott, J; Ramadan, S; Ribbons, K, 2021) |
| " Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) expressed as ratio with creatine (Cr) and NAA were correlated with markers of disease activity (RIO score), Multiple Sclerosis Severity Scale (MSSS), Depressive-Severity Status Scale and Simple Numerical Fatigue Scale." | 3.85 | Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. ( Baranovičová, E; Bittšanský, M; Čierny, D; Hnilicová, P; Kantorová, E; Kurča, E; Nosáľ, V; Poláček, H; Sivák, Š; Zeleňák, K, 2017) |
| "Since there were no changes in NAA concentration, the increase in tCr may be suggestive of gliosis, or an imbalanced equilibrium of the creatine and phosphocreatine ratio in the pons of relapsing-remitting MS patients with fatigue." | 3.83 | Fatigue in Multiple Sclerosis: Assessing Pontine Involvement Using Proton MR Spectroscopic Imaging. ( Beaulieu, C; Giuliani, F; Hanstock, C; Kalra, S; Zaini, WH, 2016) |
| "The N-acetylaspartate-creatine ratio (NAA/Cr) was significantly lower in the high-fatigue group than the low-fatigue group (mean +/- SD, 2." | 3.72 | The relationship between diffuse axonal damage and fatigue in multiple sclerosis. ( Arnold, DL; De Stefano, N; Francis, SJ; Lapierre, Y; Narayanan, S; Santos, AC; Tartaglia, MC, 2004) |
| "Fatigue was assessed using the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS) and cognition - using the Brief Repeatable Battery of Neuropsychological Tests (parts of BRBNT)." | 1.40 | Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis patients with mild disability. ( Bilinska, M; Bladowska, J; Gruszka, E; Podemski, R; Pokryszko-Dragan, A; Sasiadek, M; Slotwinski, K; Zagrajek, M; Zimny, A, 2014) |
| "Fatigue was assessed by the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS)." | 1.35 | The basal ganglia: a substrate for fatigue in multiple sclerosis. ( Alonso, J; Montalban, X; Nos, C; Río, J; Rovira, A; Téllez, N; Tintoré, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (67.39) | 18.7374 |
| 1990's | 1 (2.17) | 18.2507 |
| 2000's | 5 (10.87) | 29.6817 |
| 2010's | 7 (15.22) | 24.3611 |
| 2020's | 2 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Arm, J | 1 |
| Al-Iedani, O | 1 |
| Ribbons, K | 1 |
| Lea, R | 1 |
| Lechner-Scott, J | 1 |
| Ramadan, S | 1 |
| Mueller, C | 1 |
| Lin, JC | 1 |
| Sheriff, S | 1 |
| Maudsley, AA | 1 |
| Younger, JW | 1 |
| Agudelo, LZ | 1 |
| Ferreira, DMS | 1 |
| Dadvar, S | 1 |
| Cervenka, I | 1 |
| Ketscher, L | 1 |
| Izadi, M | 1 |
| Zhengye, L | 1 |
| Furrer, R | 1 |
| Handschin, C | 1 |
| Venckunas, T | 1 |
| Brazaitis, M | 1 |
| Kamandulis, S | 1 |
| Lanner, JT | 1 |
| Ruas, JL | 1 |
| Zick, SM | 1 |
| Zwickey, H | 1 |
| Wood, L | 1 |
| Foerster, B | 1 |
| Khabir, T | 1 |
| Wright, B | 1 |
| Ichesco, E | 1 |
| Sen, A | 1 |
| Harris, RE | 1 |
| Pokryszko-Dragan, A | 1 |
| Bladowska, J | 1 |
| Zimny, A | 1 |
| Slotwinski, K | 1 |
| Zagrajek, M | 1 |
| Gruszka, E | 1 |
| Bilinska, M | 1 |
| Sasiadek, M | 1 |
| Podemski, R | 1 |
| Zaini, WH | 1 |
| Giuliani, F | 1 |
| Beaulieu, C | 1 |
| Kalra, S | 1 |
| Hanstock, C | 1 |
| Kantorová, E | 1 |
| Poláček, H | 1 |
| Bittšanský, M | 1 |
| Baranovičová, E | 1 |
| Hnilicová, P | 1 |
| Čierny, D | 1 |
| Sivák, Š | 1 |
| Nosáľ, V | 1 |
| Zeleňák, K | 1 |
| Kurča, E | 1 |
| DeSantana, JM | 1 |
| Sluka, KA | 1 |
| dos Santos, RV | 1 |
| Caperuto, EC | 1 |
| de Mello, MT | 1 |
| Costa Rosa, LF | 1 |
| Bokemeyer, M | 1 |
| Ding, XQ | 1 |
| Goldbecker, A | 1 |
| Raab, P | 1 |
| Heeren, M | 1 |
| Arvanitis, D | 1 |
| Tillmann, HL | 1 |
| Lanfermann, H | 1 |
| Weissenborn, K | 1 |
| Pattullo, V | 1 |
| McAndrews, MP | 1 |
| Damyanovich, A | 1 |
| Heathcote, EJ | 1 |
| GHIELMETTI, G | 1 |
| BOCCHIA, A | 1 |
| RISPE, R | 1 |
| LUCAS, H | 1 |
| KRUSE, CA | 1 |
| FORMICA, PE | 1 |
| SHAW, DL | 2 |
| CHESNEY, MA | 1 |
| TULLIS, IF | 1 |
| AGERSBORG, HP | 2 |
| OGATA, M | 2 |
| SUGIYAMA, K | 2 |
| TADATOMO, A | 1 |
| HITOMI, K | 1 |
| FUKUI, T | 1 |
| ABE, T | 1 |
| TSUCHIYA, F | 1 |
| TOMINAGA, F | 1 |
| MURAKAMI, T | 1 |
| TSUNEISHI, Y | 1 |
| KINOSHITA, H | 1 |
| YAMAGOE, A | 1 |
| NIKI, K | 1 |
| FUJIOKA, H | 1 |
| YOSHIMOTO, T | 1 |
| NOGUCHI, O | 1 |
| TABIKI, T | 1 |
| CONSOLAZIO, CF | 2 |
| NELSON, RA | 2 |
| MATOUSH, LO | 2 |
| ISAAC, GJ | 2 |
| NUSSBAUM, HE | 1 |
| OLIVER, S | 1 |
| ALGODOAL, FC | 1 |
| NAGLE, FJ | 1 |
| BALKE, B | 1 |
| GANSLEN, RV | 1 |
| DAVIS, AW | 1 |
| FIERLAFIJN, E | 1 |
| OTSUKA, S | 1 |
| LEVITT, RA | 1 |
| WEBB, WB | 1 |
| TALVARD, J | 1 |
| BEAU, G | 1 |
| BONDIVENNE, R | 1 |
| DUCHENE-MARULLAZ, P | 1 |
| BARNES, RH | 1 |
| LABADAN, BA | 1 |
| SIYAMOGLU, B | 1 |
| BRADFIELD, RB | 1 |
| Tartaglia, MC | 1 |
| Narayanan, S | 1 |
| Francis, SJ | 1 |
| Santos, AC | 1 |
| De Stefano, N | 1 |
| Lapierre, Y | 1 |
| Arnold, DL | 1 |
| HICKS, JT | 1 |
| Téllez, N | 1 |
| Alonso, J | 1 |
| Río, J | 1 |
| Tintoré, M | 1 |
| Nos, C | 1 |
| Montalban, X | 1 |
| Rovira, A | 1 |
| Parisi, A | 1 |
| Quaranta, F | 1 |
| Masala, D | 1 |
| Fagnani, F | 1 |
| Di Salvo, V | 1 |
| Casasco, M | 1 |
| Pigozzi, F | 1 |
| Henderson, EG | 1 |
| Walkenstein, SS | 1 |
| Maughan, RJ | 1 |
| Sadler, DJ | 1 |
| Lehmann, M | 1 |
| Mann, H | 1 |
| Gastmann, U | 1 |
| Keul, J | 1 |
| Vetter, D | 1 |
| Steinacker, JM | 1 |
| Häussinger, D | 1 |
| Cicala, A | 1 |
| Ambrosanio, G | 1 |
| Pino, P | 1 |
| Ajazzi Mancini, M | 1 |
| Cutinelli, L | 1 |
| Sorrentino, L | 1 |
| Tramonti, C | 1 |
| Salvatore, F | 1 |
| Cedrangolo, F | 1 |
| Simon, KH | 1 |
| Lachnit, KS | 1 |
| Hurez, A | 1 |
| Garraud, R | 1 |
2 reviews available for aspartic acid and Fatigue
| Article | Year |
|---|---|
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain.
Topics: Amides; Anesthetics, Local; Aspartic Acid; Chronic Disease; Cyclic AMP; Fatigue; Fibromyalgia; Gluta | 2008 |
[CONSIDERATIONS ON POTASSIUM AND MAGNESIUM ASPARTATES AND THEIR CLINICAL POSSIBILITIES].
Topics: Aspartic Acid; Citric Acid Cycle; Fatigue; Magnesium; Metabolism; Ornithine; Potassium; Proteins | 1963 |
2 trials available for aspartic acid and Fatigue
| Article | Year |
|---|---|
The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise in man.
Topics: Adult; Ammonia; Aspartic Acid; Blood Glucose; Fatigue; Fatty Acids, Nonesterified; Heart Rate; Hemog | 1983 |
[The problem of fatigue and its treatment].
Topics: Adult; Aged; Aspartic Acid; Clinical Trials as Topic; Fatigue; Female; Humans; Male; Middle Aged; Pl | 1967 |
42 other studies available for aspartic acid and Fatigue
| Article | Year |
|---|---|
Biochemical Correlations with Fatigue in Multiple Sclerosis Detected by MR 2D Localized Correlated Spectroscopy.
Topics: Adult; Aspartic Acid; Carnosine; Choline; Creatine; Fatigue; Female; Glutathione; Gyrus Cinguli; Hum | 2021 |
Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy.
Topics: Adult; Aspartic Acid; Brain; Choline; Creatine; Fatigue; Fatigue Syndrome, Chronic; Female; Humans; | 2020 |
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Topics: Adaptation, Physiological; Animals; Aspartate Aminotransferases; Aspartic Acid; Carbidopa; Cell Resp | 2019 |
Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study.
Topics: Aspartic Acid; Biomarkers; Brain; Breast Neoplasms; Creatine; Cross-Sectional Studies; Fatigue; Fema | 2014 |
Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis patients with mild disability.
Topics: Adult; Aspartic Acid; Cognition Disorders; Disabled Persons; Fatigue; Female; Humans; Magnetic Reson | 2014 |
Fatigue in Multiple Sclerosis: Assessing Pontine Involvement Using Proton MR Spectroscopic Imaging.
Topics: Adult; Aspartic Acid; Creatine; Fatigue; Female; Humans; Middle Aged; Multiple Sclerosis; Pons; Prot | 2016 |
Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.
Topics: Adult; Aging; Aspartic Acid; Case-Control Studies; Choline; Creatine; Cross-Sectional Studies; Depre | 2017 |
Effect of exercise on glutamine metabolism in macrophages of trained rats.
Topics: Analysis of Variance; Animals; Aspartic Acid; Exercise Test; Fatigue; Glutamic Acid; Glutamine; Hydr | 2009 |
Evidence for neuroinflammation and neuroprotection in HCV infection-associated encephalopathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Case-Control Studies; Choline; Cognition Disorders | 2011 |
Influence of hepatitis C virus on neurocognitive function in patients free from other risk factors: validation from therapeutic outcomes.
Topics: Aspartic Acid; Brain; Cognition Disorders; Cohort Studies; Creatine; Fatigue; Female; Globus Pallidu | 2011 |
[Aspartic acid salts, substances with anti-fatigue properties].
Topics: Aspartic Acid; Fatigue; Salts | 1959 |
[Contribution to the study of the effects of salts of aspartic acid on fatigue in combat swimmers].
Topics: Aspartic Acid; Fatigue; Humans; Military Medicine; Salts; Swimming | 1960 |
Treatment of fatigue with aspartic acid salts.
Topics: Aspartic Acid; Fatigue; Humans; Salts | 1961 |
The housewife syndrome. Treatment with the potassium and magnesium salts of aspartic acid.
Topics: Aspartic Acid; Fatigue; Magnesium; Potassium; Salts; Syndrome | 1962 |
Management of fatigue: a physiologic approach.
Topics: Aspartic Acid; Disease Management; Fatigue; Humans | 1962 |
[Effect of K, Mg-asparate administration on fatigue. I. Effect of K, Mg-asparate on fatigue after the work load by bicycle ergometer].
Topics: Aspartic Acid; Bicycling; Exercise Test; Fatigue; Workload | 1962 |
The effect of potassium and magnesium aspartates on fatigue.
Topics: Aspartic Acid; Fatigue; Magnesium; Mental Fatigue; Potassium | 1962 |
[On the anti-fatigue effects of potassium and magnesium salts of L-aspartic acid as evaluated by several fatigue indexes].
Topics: Aspartic Acid; Fatigue; Humans; Magnesium; Potassium; Salts | 1963 |
[Effect of K, Mg-aspartate administration on fatigue. 2. Aspartic acid concentration in the serum of rabbits administered with K, Mg-aspartate].
Topics: Animals; Aspartic Acid; Fatigue; Lagomorpha; Magnesium; Occupational Medicine; Potassium; Rabbits | 1963 |
Physiologic approach to the problem of fatigue.
Topics: Aspartic Acid; Fatigue; Humans | 1962 |
Physiological and biochemical evaluation of potential antifatigue drugs. I. The effects of aspartic acid salts (Mg and K) on the performance of men.
Topics: Aspartic Acid; Fatigue; Salts | 1963 |
CHRONIC FATIGUE.
Topics: Aspartic Acid; Fatigue; Humans; Placebos; Toxicology | 1963 |
RELATIONSHIP OF FATIGUE TO GASTROINTESTINAL INADEQUACY.
Topics: Anabolic Agents; Aspartic Acid; Fatigue; Gastroenterology; Humans; Magnesium; Potassium; Steroids; T | 1963 |
THE MITIGATION OF PHYSICAL FATIGUE WITH "SPARTASE". REP 63-12.
Topics: Aspartic Acid; Biomedical Research; Exercise Test; Fatigue; Magnesium; Mental Disorders; Pharmacolog | 1963 |
[TRIAL TREATMENT OF FATIGUE STATES].
Topics: Aspartic Acid; Fatigue; Humans; Iron | 1964 |
EFFECTS OF ASPARTIC ACID SALTS (MG AND K) ON PHYSICAL PERFORMANCE OF MEN.
Topics: Aspartic Acid; Biomedical Research; Drug Therapy; Fatigue; Magnesium; Physical Fitness; Placebos; Po | 1964 |
[EFFECT OF K, MG-ASPARATE ADMINISTRATION ON FATIGUE].
Topics: Aspartic Acid; Biomedical Research; Fatigue; Magnesium; Pharmacology; Potassium | 1964 |
EFFECT OF ASPARTIC ACID SALTS ON EXHAUSTION PRODUCED BY SLEEP DEPRIVATION.
Topics: Aspartic Acid; Fatigue; Magnesium; Pharmacology; Potassium; Rats; Research; Salts; Sleep; Sleep Depr | 1964 |
[POSSIBILITY OF WORK MEASUREMENT BY THE SWIMMING TEST].
Topics: Amino Alcohols; Amphetamine; Amphetamines; Aspartic Acid; Fatigue; Pharmacology; Physical Exertion; | 1964 |
EFFECTS OF EXERCISE AND ADMINISTRATION OF ASPARTIC ACID ON BLOOD AMMONIA IN THE RAT.
Topics: Ammonia; Aspartic Acid; Blood; Exercise; Fatigue; Metabolism; Ornithine; Pharmacology; Physical Exer | 1964 |
The relationship between diffuse axonal damage and fatigue in multiple sclerosis.
Topics: Adult; Aspartic Acid; Axons; Brain Chemistry; Creatine; Cross-Sectional Studies; Fatigue; Female; Hu | 2004 |
TREATMENT OF FATIGUE IN GENERAL PRACTICE: A DOUBLE BLIND STUDY.
Topics: Aspartic Acid; Double-Blind Method; Family Practice; Fatigue; Hypoxia; Magnesium; Mice; Pharmacology | 1964 |
The basal ganglia: a substrate for fatigue in multiple sclerosis.
Topics: Adolescent; Adult; Aspartic Acid; Choline; Corpus Striatum; Creatine; Disability Evaluation; Energy | 2008 |
Do aspartate and asparagine acute supplementation influence the onset of fatigue in intense exercise?
Topics: Adult; Asparagine; Aspartic Acid; Cross-Over Studies; Double-Blind Method; Exercise; Fatigue; Humans | 2007 |
Repolarization of striated muscle fibers by the antifatigue agent, K-Mg-aspartate.
Topics: Animals; Anura; Aspartic Acid; Calcium Chloride; Chlorides; Culture Media; Electrophysiology; Fatigu | 1967 |
Unaccustomed high-mileage vs intensity training-related changes in performance and serum amino acid levels.
Topics: Adult; Amino Acids; Arginine; Asparagine; Aspartic Acid; Cystine; Erythrocyte Count; Exercise Test; | 1996 |
[On the use of a preparation of acetylaspartic acid and citrullin in aeronautic sport practice].
Topics: Adolescent; Adult; Aerospace Medicine; Aspartic Acid; Audiometry; Citrulline; Fatigue; Humans; Male; | 1965 |
[The problems of "fatigue" in the light of the most recent advances in biochemistry].
Topics: Adenine Nucleotides; Animals; Asparagine; Aspartic Acid; Fatigue; Humans; Magnesium; Muscles; Potass | 1970 |
Protection by ornithine-aspartate of the effects of physical exercise.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alanine Transaminase; Ammonia; Animals; Aspartate Amino | 1970 |
[The therapy of states of exhaustion with Ornithin-Aspartat].
Topics: Aspartic Acid; Fatigue; Female; Humans; Male; Ornithine | 1968 |
[Attempt of clinical application of aspartic acid in geriatrics].
Topics: Aged; Aspartic Acid; Blood Cell Count; Body Weight; Electrocardiography; Fatigue; Female; Geriatrics | 1965 |
[Clinical study of bio-stimulant preparation in pediatric therapeutics].
Topics: Adolescent; Aspartic Acid; Asthenia; Child; Child, Preschool; Fatigue; Female; Humans; Male; Vitamin | 1966 |