Page last updated: 2024-10-25

amphetamine and Fatigue

amphetamine has been researched along with Fatigue in 36 studies

Amphetamine: A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
1-phenylpropan-2-amine : A primary amine that is isopropylamine in which a hydrogen attached to one of the methyl groups has been replaced by a phenyl group.
amphetamine : A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.

Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.

Research Excerpts

ExcerptRelevanceReference
"Amphetamine is a stimulant drug that enhances attention and feelings of alertness."6.75More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. ( de Wit, H; Dlugos, AM; Goldman, D; Hamidovic, A; Hodgkinson, CA; Palmer, AA, 2010)
"Chronic fatigue is a complex and little understood symptom for which there is no safe and effective pharmacotherapy."5.33Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. ( Brown-Borg, HM; Dhanasekaran, M; Manyam, BV; Tharakan, B, 2006)
"Amphetamine is a stimulant drug that enhances attention and feelings of alertness."2.75More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. ( de Wit, H; Dlugos, AM; Goldman, D; Hamidovic, A; Hodgkinson, CA; Palmer, AA, 2010)
"Chronic fatigue is a complex and little understood symptom for which there is no safe and effective pharmacotherapy."1.33Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. ( Brown-Borg, HM; Dhanasekaran, M; Manyam, BV; Tharakan, B, 2006)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199029 (80.56)18.7374
1990's1 (2.78)18.2507
2000's3 (8.33)29.6817
2010's2 (5.56)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Morelli, M1
Tognotti, E1
Morozova, E1
Yoo, Y1
Behrouzvaziri, A1
Zaretskaia, M1
Rusyniak, D1
Zaretsky, D1
Molkov, Y1
Ramsey, CS1
Werchan, PM1
Isdahl, WM1
Fischer, J1
Gibbons, JA1
Dlugos, AM1
Hamidovic, A1
Hodgkinson, CA1
Goldman, D1
Palmer, AA1
de Wit, H1
TYLER, DB1
RUDOLF, GD1
NEWMAN, HW1
SOMERVILLE, W1
Gabbay, FH1
LEAKE, CD2
JAFFE, I1
KISSIN, B1
ROSENBLATT, P1
PICKARD, K1
GALLOP, C1
TEBROCK, HE1
YOUNG, W1
O'DONNELL, W1
KAUFMAN, M1
MAROZZI, E1
TALVARD, J1
BEAU, G1
BONDIVENNE, R1
DUCHENE-MARULLAZ, P1
Tharakan, B1
Dhanasekaran, M1
Brown-Borg, HM1
Manyam, BV1
Cytawa, J1
Oliverio, A1
Akerstedt, T1
Ficca, G1
Quatrini, U1
Orlando, F1
Benigno, A1
Koella, WP1
Heimann, H1
Lukàcs, G1
van Rossum, JM1
Meyer, RE1
DiMascio, A1
Stifler, L1
Bujas, Z1
Iakovlev, NN1
Pearlman, CA1
Greenberg, R1
Spann, W1
Garaseva, TS1
Boutantin, MO1
Beck, CH1
Chambers, WW1
Wagner, HJ1
Frommel, E1
Seydoux, J1
von Ledebur, I1
Chmouliovsky, M1
Prasad, CR1
Paulshock, BZ1
Watkins, C1
Jackson, B1
Reed, A1
Kiplinger, GF1

Reviews

6 reviews available for amphetamine and Fatigue

ArticleYear
Brief history of the medical and non-medical use of amphetamine-like psychostimulants.
    Experimental neurology, 2021, Volume: 342

    Topics: Altitude Sickness; Amphetamine; Animals; Armed Conflicts; Attention Deficit Disorder with Hyperactiv

2021
Alertness-enhancing drugs as a countermeasure to fatigue in irregular work hours.
    Chronobiology international, 1997, Volume: 14, Issue:2

    Topics: Amphetamine; Benzhydryl Compounds; Caffeine; Central Nervous System Stimulants; Fatigue; Humans; Mod

1997
CNS-related (side-)effects of beta-blockers with special reference to mechanisms of action.
    European journal of clinical pharmacology, 1985, Volume: 28 Suppl

    Topics: Adrenergic beta-Antagonists; Amphetamine; Animals; Anxiety; Blood-Brain Barrier; Central Nervous Sys

1985
[Psychophysiological studies of some aspects of fatigue and rest].
    Arhiv za higijenu rada i toksikologiju, 1968, Volume: 19, Issue:3

    Topics: Action Potentials; Age Factors; Amphetamine; Animals; Competitive Behavior; Efficiency; Electric Sti

1968
[Physiological aspects of endurance during muscular activity].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1970, Volume: 56, Issue:9

    Topics: Adenosine Triphosphate; Amphetamine; Brain; Fatigue; Humans; Mitochondria, Muscle; Muscles; Myocardi

1970
Medical-psychological implications of recent sleep research.
    Psychiatry in medicine, 1970, Volume: 1, Issue:4

    Topics: Adaptation, Psychological; Amphetamine; Barbiturates; Central Nervous System Stimulants; Chloral Hyd

1970

Trials

2 trials available for amphetamine and Fatigue

ArticleYear
More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Amidohydrolases; Amphetamine; Arousal; Cross-Over Studies; Double-Blind Method; F

2010
Variations in affect following amphetamine and placebo: markers of stimulant drug preference.
    Experimental and clinical psychopharmacology, 2003, Volume: 11, Issue:1

    Topics: Adult; Affect; Amphetamine; Amphetamine-Related Disorders; Central Nervous System Stimulants; Cognit

2003

Other Studies

28 other studies available for amphetamine and Fatigue

ArticleYear
Amphetamine enhances endurance by increasing heat dissipation.
    Physiological reports, 2016, Volume: 4, Issue:17

    Topics: Amphetamine; Animals; Body Temperature Regulation; Central Nervous System Stimulants; Cross-Over Stu

2016
Acceleration tolerance at night with acute fatigue and stimulants.
    Aviation, space, and environmental medicine, 2008, Volume: 79, Issue:8

    Topics: Acceleration; Adaptation, Physiological; Adult; Aerospace Medicine; Amphetamine; Analysis of Varianc

2008
The effect of amphetamine sulfate and some barbiturates on the fatigue produced by prolonged wakefulness.
    The American journal of physiology, 1947, Volume: 150, Issue:2

    Topics: Amphetamine; Barbital; Barbiturates; Fatigue; Humans; Sulfates; Wakefulness

1947
The effect of amphetamine on fatigue and depression.
    The British journal of addiction to alcohol and other drugs, 1947, Volume: 44, Issue:2

    Topics: Amphetamine; Amphetamines; Depression; Depressive Disorder; Fatigue; Humans

1947
The effect of amphetamine sulfate on performance of normal and fatigued subjects.
    The Journal of pharmacology and experimental therapeutics, 1947, Volume: 89, Issue:2

    Topics: Amphetamine; Amphetamines; Fatigue; Humans

1947
The effect of benzedrine on mental or physical fatigue in soldiers.
    Canadian Medical Association journal, 1946, Volume: 55, Issue:5

    Topics: Amphetamine; Amphetamines; Fatigue; Humans; Military Personnel; Physical Examination

1946
The amphetamines and the sleepy driver.
    The Ohio State medical journal, 1957, Volume: 53, Issue:2

    Topics: Accidents, Traffic; Amphetamine; Fatigue; Humans; Sleep Stages

1957
The amphetamines and the sleepy driver.
    The Ohio State medical journal, 1957, Volume: 53, Issue:2

    Topics: Accidents, Traffic; Amphetamine; Fatigue; Humans; Sleep Stages

1957
The amphetamines and the sleepy driver.
    The Ohio State medical journal, 1957, Volume: 53, Issue:2

    Topics: Accidents, Traffic; Amphetamine; Fatigue; Humans; Sleep Stages

1957
The amphetamines and the sleepy driver.
    The Ohio State medical journal, 1957, Volume: 53, Issue:2

    Topics: Accidents, Traffic; Amphetamine; Fatigue; Humans; Sleep Stages

1957
Studies in psychic fatigue. II. Physiological effects of D-amphetamine.
    American practitioner and digest of treatment, 1959, Volume: 10, Issue:4

    Topics: Amphetamine; Amphetamines; Dextroamphetamine; Fatigue; Humans

1959
A combined psychic and somatic stimulant in the management of industrial fatigue and mild depression.
    International record of medicine, 1959, Volume: 172

    Topics: Amphetamine; Amphetamines; Central Nervous System Stimulants; Depression; Fatigue; Humans; Occupatio

1959
[TESTING OF THE VIDIC REACTION, USED FOR THE DETECTION OF "DOPING" IN ATHLETES, ON SEVERAL SUBSTANCES OF VARIOUS TYPES].
    Il Farmaco; edizione pratica, 1964, Volume: 19

    Topics: Aminobutyrates; Amphetamine; Amphetamines; Athletes; Central Nervous System Stimulants; Choline; Eph

1964
[POSSIBILITY OF WORK MEASUREMENT BY THE SWIMMING TEST].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Amino Alcohols; Amphetamine; Amphetamines; Aspartic Acid; Fatigue; Pharmacology; Physical Exertion;

1964
Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity.
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:3

    Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Chronic Disease; Dioscoreaceae; Fatigu

2006
[Studies on the phenomenon of fatigue of conditioned reflexes. IV. Effect of chlorpromazine, reserpine and amphetamine on conditioned reflexes].
    Acta physiologica Polonica, 1967, Volume: 18, Issue:1

    Topics: Amphetamine; Animals; Chlorpromazine; Conditioning, Classical; Fatigue; Hypothalamus; Limbic System;

1967
Analysis of the "anti-fatigue" activity of amphetamine. Role of central adrenergic mechanisms.
    Il Farmaco; edizione scientifica, 1967, Volume: 22, Issue:6

    Topics: Amphetamine; Animals; Avoidance Learning; Desipramine; Drug Antagonism; Escape Reaction; Fatigue; Me

1967
[Behavior of blood pyruvate in albino rats at rest or during muscular fatigue after administration of beta-phenyl-isopropylamine].
    Bollettino della Societa italiana di biologia sperimentale, 1976, Mar-30, Volume: 52, Issue:6

    Topics: Amphetamine; Animals; Fatigue; Female; Male; Physical Exertion; Pyruvates; Rats

1976
[Experimental psychological differentiation of the effect of 2 psychostimulants (F-1983 and amphetamine) in humans].
    Psychopharmacologia, 1965, Jul-28, Volume: 8, Issue:2

    Topics: Amphetamine; Central Nervous System Stimulants; Fatigue; Humans; Motor Skills; Placebos; Psychopharm

1965
[The effect of psychostimulants on the central and autonomic nervous system].
    Schweizerische Zeitschrift fur Sportmedizin, 1967, Volume: 15, Issue:1

    Topics: Amphetamine; Autonomic Nervous System; Central Nervous System; Central Nervous System Stimulants; Fa

1967
Personality differences in the response to stimulant drugs administered during a sleep-deprived state.
    The Journal of nervous and mental disease, 1970, Volume: 150, Issue:2

    Topics: Adult; Affect; Amphetamine; Blood Pressure; Ethylamines; Fatigue; Humans; Male; Mental Fatigue; Moto

1970
[Doping in sport from the medical view point].
    Fortschritte der Medizin, 1974, Jul-18, Volume: 92, Issue:20

    Topics: Amphetamine; Anabolic Agents; Fatigue; Female; Humans; Male; Motor Skills; Narcotics; Oxygen; Sports

1974
[Effect of the adrenergic substrate of the brainstem reticular formation on the development of fatigue from static loads].
    Gigiena truda i professional'nye zabolevaniia, 1973, Volume: 17, Issue:7

    Topics: Adult; Amphetamine; Chlorpromazine; Electromyography; Fatigue; Humans; Male; Physical Exertion; Rece

1973
[Action of amphetamine and an aqueous pollen extract on muscle fatigue in mice].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1969, Aug-04, Volume: 269, Issue:5

    Topics: Amphetamine; Animals; Fatigue; Female; Mice; Muscles; Physical Exertion; Phytotherapy; Plant Extract

1969
Speed, accuracy, and strength of forelimb movement after unilateral pyramidotomy in rhesus monkeys.
    Journal of comparative and physiological psychology, 1970, Volume: 70, Issue:2

    Topics: Amphetamine; Animals; Fatigue; Forearm; Haplorhini; Motor Skills; Movement; Muscles; Physical Exerti

1970
["Sleep for seconds" in elderly automobile drivers].
    Deutsche medizinische Wochenschrift (1946), 1972, Jun-02, Volume: 97, Issue:22

    Topics: Amphetamine; Automobile Driving; Caffeine; Fatigue; Gymnastics; Humans; Middle Aged; Sleep; Substanc

1972
Neuropharmacological study of central reactions to intense muscular exertion, sensorial fatigue, sexual excitation, hunger, and thirst.
    Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1966, Volume: 14

    Topics: Amphetamine; Animals; Brain; Electric Stimulation; Electroshock; Fatigue; Female; Guinea Pigs; Hunge

1966
Coping on amphetamines.
    The New England journal of medicine, 1970, Feb-05, Volume: 282, Issue:6

    Topics: Amphetamine; Antidepressive Agents; Depression; Fatigue; Humans

1970
Use of amphetamine by medical students.
    Southern medical journal, 1970, Volume: 63, Issue:8

    Topics: Amphetamine; Fatigue; Humans; Learning; Mental Disorders; Narcotics; Physicians; Students; Students,

1970
Another abusable amphetamine.
    JAMA, 1970, Feb-02, Volume: 211, Issue:5

    Topics: Amphetamine; Anxiety; Fatigue; Humans; Substance-Related Disorders; Wisconsin

1970
The effects of drugs on the rate of development of fatigue in mice.
    Texas reports on biology and medicine, 1967,Winter, Volume: 25, Issue:4

    Topics: Amphetamine; Animals; Dextroamphetamine; Fatigue; Imipramine; Male; Methods; Mice; Morphine; Pentoba

1967