reserpine has been researched along with Fatigue in 11 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-γ antagonist, aggravated the FM manifestations in the rat model." | 8.02 | Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. ( Attia, MH; Eid, DM; Hassan, FE; Mohamed, AS; Mohie, PM; Sakr, HI; Suliman, HS, 2021) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 5.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| "Pioglitazone significantly relieved fatigue, improved muscle performance, reduced inflammatory cytokines and enhanced antioxidant's activity, while GW9662, a known PPAR-γ antagonist, aggravated the FM manifestations in the rat model." | 4.02 | Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model. ( Attia, MH; Eid, DM; Hassan, FE; Mohamed, AS; Mohie, PM; Sakr, HI; Suliman, HS, 2021) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 1.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Brum, EDS | 1 |
| Fialho, MFP | 1 |
| Fischer, SPM | 1 |
| Hartmann, DD | 1 |
| Gonçalves, DF | 1 |
| Scussel, R | 1 |
| Machado-de-Ávila, RA | 1 |
| Dalla Corte, CL | 1 |
| Soares, FAA | 1 |
| Oliveira, SM | 1 |
| Hassan, FE | 1 |
| Sakr, HI | 1 |
| Mohie, PM | 1 |
| Suliman, HS | 1 |
| Mohamed, AS | 1 |
| Attia, MH | 1 |
| Eid, DM | 1 |
| Cytawa, J | 1 |
| Bolland, G | 1 |
| Bauer, B | 1 |
| Seyfarth, HJ | 1 |
| Rosen, RC | 1 |
| Kostis, JB | 1 |
| Gona, AG | 1 |
| Gona, O | 1 |
| Snaith, RP | 1 |
| McCoubrie, M | 1 |
| Franklin, KB | 1 |
| Herberg, LJ | 1 |
| Hartmann, E | 1 |
| Cravens, J | 1 |
| Konradi, GP | 1 |
| Vasil'eva, LI | 1 |
| Villeneuve, A | 1 |
1 review available for reserpine and Fatigue
| Article | Year |
|---|---|
Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: a critical review.
Topics: Animals; Antihypertensive Agents; Cats; Cognition; Depression; Electroencephalography; Fatigue; Feed | 1985 |
2 trials available for reserpine and Fatigue
| Article | Year |
|---|---|
[Reaction performance, motor coordination performance and findings in hypertensive patients under diisopropylamine and reserpine therapy].
Topics: Adult; Age Factors; Blood Pressure; Fatigue; Humans; Hypertension; Male; Middle Aged; Motor Skills; | 1979 |
The effects of long term administration of psychotropic drugs on human sleep. II. The effects of reserpine.
Topics: Adult; Amitriptyline; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; D | 1973 |
8 other studies available for reserpine and Fatigue
| Article | Year |
|---|---|
Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Fatigue; Fibromyalgia; Male; Mice; Mi | 2020 |
Pioglitazone improves skeletal muscle functions in reserpine-induced fibromyalgia rat model.
Topics: Animals; Fatigue; Fibromyalgia; Humans; Male; Muscle, Skeletal; Pioglitazone; PPAR gamma; Rats; Rats | 2021 |
[Studies on the phenomenon of fatigue of conditioned reflexes. IV. Effect of chlorpromazine, reserpine and amphetamine on conditioned reflexes].
Topics: Amphetamine; Animals; Chlorpromazine; Conditioning, Classical; Fatigue; Hypothalamus; Limbic System; | 1967 |
Prolactin-releasing effects of centrally-acting drugs in the red-spotted newt, Notophthalmus viridescens.
Topics: Animals; Dose-Response Relationship, Drug; Fatigue; Injections, Intraperitoneal; Metamorphosis, Biol | 1974 |
Antihypertensive drugs and depression.
Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Thera | 1974 |
Self-stimulation and catecholamines: drug-induced mobilization of the 'reserve'-pool re-establishes responding in catecholamine-depleted rats.
Topics: Animals; Catecholamines; Depression, Chemical; Fatigue; Male; Methamphetamine; Methylphenidate; Meth | 1974 |
[The effect of sympathetic cholinergic innervation on fatigued skeletal muscle].
Topics: Acetylcholine; Animals; Cats; Ergotamine; Fatigue; Hypothalamus; Muscle Contraction; Muscles; Reserp | 1972 |
The rabbit syndrome. A peculiar extrapyramidal reaction.
Topics: Aged; Anxiety; Basal Ganglia Diseases; Benztropine; Chlorpromazine; Fatigue; Female; Humans; Male; M | 1972 |