Bone Stress Reaction

Fractures due to the strain caused by repetitive exercise. They are thought to arise from a combination of MUSCLE FATIGUE and bone failure, and occur in situations where BONE REMODELING predominates over repair. The most common sites of stress fractures are the METATARSUS; FIBULA; TIBIA; and FEMORAL NECK.

Synonym
Fractures, March
Micro Fractures
Fractures, Fatigue
Stress Reaction, Bone
Bone Stress Reaction
Fractures, Stress
Fatigue Fractures
Insufficiency Fractures
Stress Fractures
Microfractures

Excerpt	Reference
"Stress fractures are infrequently seen in non-weight-bearing bones."	( Geiser, C; Raasch, WG; Young, CC, 1995)
"Stress fractures are common injuries in sports medicine clinics."	( Lombardo, JA; Waninger, KN, 1995)
"In rowing, stress fractures are rare."	( Christiansen, E; Kanstrup, IL, 1997)
"Stress fractures are common in endurance athletes and in military populations; however, stress fracture of the acetabulum is uncommon."	( Denison, G; Gorman, JD; Puckett, ML; Shin, AY; Williams, TR, 2002)
"Stress fractures are commonplace in military populations, especially endurance trainees."	( Denison, G; Gorman, JD; Puckett, ML; Shin, AY; Williams, TR, 2002)
"Tibial stress fractures are an important cause of lameness in the Thoroughbred racehorse."	( Head, MJ; Newton, JR; Ramzan, PH; Shepherd, MC, 2003)
"Fatigue fractures are not exceptional in unselected adults."	( Armesto, V; Garcia-Porrua, C; Gonzalez-Gay, MA; Mañana, P, 2003)
"Stress fractures are a common and serious overuse injury in runners, particularly female runners."	( Davis, IS; Hamill, J; Milner, CE, 2006)
"Femoral diaphyseal stress fractures are often inconspicuous with conventional radiography."	( Resnick, D; Theodorou, DJ; Theodorou, SJ, 2006)
"Stress fractures are the injuries of soft tissues and bones caused by intensive and repeated stress on a bone."	( Ajdinović, B; Dopuda, M; Gardasević, K; Jauković, L, 2008)
"Lower extremity stress fractures are relatively common among competitive athletes."	( Heffernan, MJ; Li, X; Mortimer, ES, 2010)
"Sacral stress fractures are included among the many possibilities."	( Black, KP; Silvis, ML; Southam, JD, 2010)
"Stress fractures are common injuries in athletes and military recruits."	( Kapil, N; Patel, DS; Roth, M, 2011)
"Fifth metatarsal stress fractures are common in sports and often result in delayed and non-union."	( Abbey, AN; Butler, RJ; Nunley, JA; Queen, RM; Verma, R, 2014)
"Insufficiency fractures are a common cause of morbidity among geriatric patients worldwide."	( Burk, DR; Smith, JL; Wild, JR, 2017)
"Stress fractures are a limitation for athletes not only in sports performance but in activities of daily living."	( Ishida, H; Ito, E; Kobayashi, T; Matsumoto, H; Matsumoto, M; Miyamoto, K; Miyamoto, T; Nakamura, M; Nishiwaki, Y; Oguma, Y; Otani, T; Sato, Y; Tani, M, 2018)
"Debilitating stress fractures are surprisingly common in physically active individuals, including athletes, military recruits, and dancers."	( Fertala, A; Park, J; Tomlinson, RE, 2019)

Excerpt	Reference
"Prevention of stress fractures has been studied in military personnel, but more research is needed in other populations."	( Kapil, N; Patel, DS; Roth, M, 2011)

Excerpt	Reference
"Trabecular stress fractures tend to occur in the first 18 months of treatment, and cortical stress fractures occur after 30 months of therapy."	( Gear, KA; Robson, HJ; Schnitzler, CM; Wing, JR, 1990)
"This can cause subchondral stress fractures in the growing cartilage that later on, if missed or not sufficiently treated, can cause osteochondrosis dissecans."	( Goesele, A; Morscher, E; Segesser, B, 1995)
"This report describes the development of stress fractures during initial cycles of treatment, with recurrence of symptoms in two patients when etidronate therapy was resumed."	( Collado, A; Guañabens, N; Monegal, A; Muñoz-Gómez, J; Peris, P; Pons, F, 1994)
"This case report demonstrates that stress fractures secondary to osteoporosis may be associated with prolonged magnesium sulfate therapy and bed rest in higher order multiple pregnancy."	( Chan, L; Levav, AL; Wapner, RJ, 1998)
"These insufficiency fractures could possibly have developed from the over suppression of bone turnover from prolonged alendronate therapy, in keeping with recently published evidence."	( Goh, SK; Howe, TS; Koh, JS; Kwek, EB; Png, MA, 2008)
"Treatment of stress fractures consists of activity modification, including the use of nonweight-bearing crutches if needed for pain relief."	( Kapil, N; Patel, DS; Roth, M, 2011)
"Recently stress fractures associated with zoledronic acid therapy for osteoporosis have attracted attention."	( Ishiguro, N; Iwase, T; Kishimoto, Y; Koyama, A; Masui, T; Matsuo, H; Yoshida, G, 2011)
"The authors present 2 cases of insufficiency fractures occurring in geriatric patients receiving warfarin therapy reversed with a 3-factor PCC."	( Burk, DR; Smith, JL; Wild, JR, 2017)
"Although fatigue and insufficiency fractures can be self-limited and go onto healing even without diagnosis, there is usually value in initiating prompt therapeutic measures as incomplete stress fractures have the potential of progressing to completion and requiring more invasive treatment or delay in return to activity."	( Appel, M; Baccei, SJ; Bencardino, JT; Cassidy, RC; Chang, EY; Fox, MG; Greenspan, BS; Gyftopoulos, S; Hochman, MG; Jacobson, JA; Mintz, DN; Mlady, GW; Newman, JS; Roberts, CC; Rosenberg, ZS; Shah, NA; Small, KM; Stone, TJ; Weissman, BN, 2017)
"The sacrum insufficiency fractures (SIFs) were graded according to the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer toxicity criteria."	( Fukahori, M; Furuichi, W; Imai, R; Ishikawa, H; Kanematsu, N; Koto, M; Matsumoto, S; Miyasaka, Y; Mori, Y; Murata, K; Okonogi, N; Tsuji, H; Wakatsuki, M; Yamada, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	24 (5.87)	23.3326
1990's	98 (23.96)	12.5806
2000's	113 (27.63)	18.1394
2010's	122 (29.83)	28.8240
2020's	52 (12.71)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
adenine	low	1	0
methane	low	1	0
salicylic acid	low	1	0
lactic acid	low	2	0
iodine	low	2	0
nickel	low	2	0
pyruvic acid	low	1	0
alendronate	low	39	0
aspirin	low	2	0
caffeine	low	1	0
carbamazepine	low	1	0
celecoxib	low	1	0
pentetic acid	low	2	0
etidronate	medium	11	2
gabapentin	low	1	0
glyphosate	low	5	0
haloperidol	low	1	0
ibuprofen	low	1	0
ipriflavone	low	1	0
losartan	low	1	0
memantine	low	1	0
methylphenidate	low	3	0
ethylmaleimide	low	1	0
nortriptyline	low	1	0
pamidronate	low	7	0
sodium fluoride	medium	11	1
risedronic acid	medium	6	1
terbutaline	low	1	0
tranexamic acid	low	1	0
urethane	low	1	0
prednisolone	low	4	0
hydroxyproline	low	1	0
thyroxine	low	1	0
prednisone	low	4	0
dehydroepiandrosterone	low	1	0
lysine	low	2	0
levodopa	low	1	0
methylene blue	low	1	0
medroxyprogesterone acetate	low	1	0
arginine	low	2	0
isoprene	low	1	0
methylmethacrylate	low	4	0
methylprednisolone	low	2	0
melamine	low	1	0
thiophenes	low	2	0
meglumine	low	1	0
limestone	medium	3	1
lithium carbonate	low	1	0
glycopyrrolate	low	1	0
c.i. 42510	low	4	0
bisphenol a-glycidyl methacrylate	low	1	0
technetium	low	10	0
titanium	low	6	0
gadolinium	low	2	0
zirconium	low	1	0
magnesium sulfate	low	1	0
tricalcium phosphate	low	3	0
fluorine	low	1	0
trolamine salicylate	low	19	0
ammonium chloride	medium	1	1
fluorides	low	2	0
triamcinolone	low	2	0
ursodeoxycholic acid	low	1	0
transferrin	low	1	0
tramadol	medium	1	1
propiconazole	low	2	0
raloxifene hydrochloride	low	3	0
ibandronic acid	low	3	0
3-iodobenzylguanidine	low	1	0
fluorophosphate	low	1	0
fluorodeoxyglucose f18	low	6	0
zoledronic acid	low	4	0
vitamin b 6	low	1	0
pyridinoline	low	1	0
deoxypyridinoline	low	4	0
deoxyglucose	low	1	0
pentosidine	low	3	0
technetium tc 99m hydroxymethylene diphosphonate	low	7	0
technetium tc 99m etidronate	low	1	0
methotrexate	low	11	0
naproxen	low	1	0
organophosphonates	low	1	0
cimadronate	low	1	0
fibrin	low	3	0
retinol	low	1	0
tenofovir	low	2	0
suberoylbisphosphonic acid	low	1	0
nitinol	low	1	0
osteoprotegerin	low	2	0
calcitriol	low	1	0
vitamin k semiquinone radical	low	2	0
vitamin d 2	low	2	0
cholecalciferol	low	6	0
menaquinone 6	low	1	0
iloprost	medium	1	1
icariin	low	1	0
lead	low	1	0
aluminum	low	2	0
phosphorus	low	2	0
heroin	low	1	0
gadolinium dtpa	low	4	0
carboxyl radical	low	1	0
technetium tc 99m diphosphonate	low	4	0
granite	low	1	0
acid phosphatase	medium	5	1
vendex	low	8	0
chitosan	low	4	0
technetium tc 99m sestamibi	low	1	0
sodium ethylxanthate	low	1	0
gdc 0449	low	1	0
piroxicam	medium	1	1
mobiflex	medium	1	1
warfarin	low	2	0
transforming growth factor beta	low	3	0
gallium ga 68 dotatate	low	1	0
orabase	low	1	0
technetium tc 99m medronate	low	44	0
acyclovir	low	1	0

Protein Targets (954)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
dopamine D1 receptor	4	0	0	4
thioredoxin reductase	18	0	0	18
GLS protein	10	0	0	10
Thrombopoietin	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C19 precursor	5	0	0	5
ras-related protein Rab-9A	3	0	0	3
histone acetyltransferase KAT2A isoform 1	10	0	0	10
lethal factor (plasmid)	6	0	0	6
POU domain, class 2, transcription factor 1	0	0	0	1
Spike glycoprotein	12	0	0	12
ATP-dependent phosphofructokinase	14	0	0	14
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	10	0	0	10
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	13	0	0	13
TDP1 protein	29	0	0	29
Smad3	6	0	0	6
thyroid stimulating hormone receptor	13	0	0	13
EWS/FLI fusion protein	17	0	0	17
arylsulfatase A	10	0	0	10
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
activating transcription factor 6	8	0	0	8
Histone H2A.x	7	0	0	7
Bloom syndrome protein isoform 1	13	0	0	13
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
lamin isoform A-delta10	21	0	0	21
Solute carrier family 22 member 1	0	3	0	4
ATP-binding cassette sub-family C member 3	0	20	0	20
Multidrug resistance-associated protein 4	0	20	0	21
Solute carrier family 22 member 6	0	5	0	6
Bile salt export pump	0	5	0	5
Bile salt export pump	0	31	0	31
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	15	0	17
Cytochrome P450 2J2	0	9	0	9
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	5	0	8
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	6
Canalicular multispecific organic anion transporter 1	0	20	0	20
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	16	0	0	16
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	26	0	0	26
AR protein	34	0	0	34
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
glucocorticoid receptor [Homo sapiens]	33	0	0	33
estrogen-related nuclear receptor alpha	29	0	0	29
pregnane X nuclear receptor	23	0	0	23
estrogen nuclear receptor alpha	44	0	0	44
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	14
heat shock protein beta-1	11	0	0	11
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	16	0	0	16
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	12	0	0	12
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	15	0	0	15
Ataxin-2	16	0	0	16
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	7	0	8
Farnesyl pyrophosphate synthase	0	12	0	12
Acetylcholinesterase	0	5	0	5
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	7	0	7
Farnesyl pyrophosphate synthase	0	3	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	5	0	0	5
alpha-galactosidase	2	0	0	2
chromobox protein homolog 1	13	0	0	13
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	11	0	0	11
muscarinic acetylcholine receptor M1	8	0	0	8
Cytochrome P450 3A4	0	7	0	11
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
GTP-binding protein (rab7)	0	0	2	2
ras protein, partial	0	0	2	2
interleukin 8	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
hypothetical protein, conserved	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
cytochrome P450 2D6	12	0	0	12
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	16	0	0	16
Rac1 protein	0	0	2	2
IDH1	14	0	0	14
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	2	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Prostaglandin G/H synthase 2	0	4	0	4
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	10	0	11
Carbonic anhydrase 2	0	10	1	12
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	5	1	0	6
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Integrin alpha-IIb	5	1	0	6
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	9	0	10
Adenosine receptor A1	0	7	0	9
Adenosine receptor A2a	0	6	0	9
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	10	1	12
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	6	0	0	6
Ras-related protein Rab-2A	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	10	4	1	15
Prostaglandin G/H synthase 2	0	6	0	6
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Chain A, Beta-lactamase	12	0	0	12
glp-1 receptor, partial	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
SMAD family member 2	12	0	0	12
ATAD5 protein, partial	12	0	0	12
SMAD family member 3	12	0	0	12
GLI family zinc finger 3	24	0	0	24
TSHR protein	2	0	0	2
estrogen receptor 2 (ER beta)	14	0	0	14
progesterone receptor	18	0	0	18
retinoid X nuclear receptor alpha	22	0	0	22
farnesoid X nuclear receptor	15	0	0	15
67.9K protein	5	0	0	5
peroxisome proliferator activated receptor gamma	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	21	0	0	21
aryl hydrocarbon receptor	13	0	0	13
thyroid stimulating hormone receptor	10	0	0	10
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
thyroid hormone receptor beta isoform 2	25	0	0	25
DNA polymerase eta isoform 1	5	0	0	5
geminin	29	0	0	29
Cellular tumor antigen p53	24	0	0	24
Alpha-synuclein	6	1	0	7
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	24	0	0	24
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
thyroid hormone receptor beta isoform a	11	0	0	11
DNA polymerase beta	5	0	0	5
nuclear receptor ROR-gamma isoform 1	10	0	0	10
Potassium channel subfamily K member 2	0	1	1	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Adenosine receptor A3	0	3	0	3
Replicase polyprotein 1ab	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	1	4
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	1	1	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
Guanine deaminase	0	1	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	12	0	0	12
PPM1D protein	5	0	0	5
Microtubule-associated protein tau	8	0	0	8
thioredoxin glutathione reductase	8	0	0	8
mitogen-activated protein kinase 1	5	0	0	5
peripheral myelin protein 22	13	0	0	13
Interferon beta	16	0	0	16
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Androgen receptor	0	5	2	7
Cytochrome P450 2D6	0	5	0	5
Vitamin D3 receptor	0	3	4	11
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Cytochrome P450 2C19	0	3	0	3
Kappa-type opioid receptor	0	1	1	2
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
acetylcholinesterase	9	0	0	9
Vpr	2	0	0	2
Albumin	0	0	5	5
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	5	0	0	5
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
pregnane X receptor	6	0	0	6
caspase 7, apoptosis-related cysteine protease	4	0	0	4
G	12	0	0	12
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
caspase-3	4	0	0	4
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	3	0	0	3
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
caspase-3	3	0	0	3
cytochrome P450 3A4 isoform 1	10	0	0	10
Gamma-aminobutyric acid receptor subunit pi	10	2	0	12
Prostaglandin E synthase	0	1	0	1
Histone deacetylase 3	0	2	0	2
3-phosphoinositide-dependent protein kinase 1	0	1	0	1
Carbonic anhydrase 12	0	3	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Carbonic anhydrase 3	0	2	0	3
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	8	0	8
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Beta-3 adrenergic receptor	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	10	2	0	12
Alpha-1B adrenergic receptor	0	5	0	5
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-2	10	2	1	13
5-hydroxytryptamine receptor 1A	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-3	10	2	0	12
D(1A) dopamine receptor	0	6	0	7
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase 6	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	10	2	0	12
Gamma-aminobutyric acid receptor subunit alpha-2	10	2	0	12
Sodium-dependent noradrenaline transporter	0	10	1	11
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	10	2	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	10	2	0	12
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	10	2	0	12
Sodium-dependent serotonin transporter	0	8	0	8
Sodium-dependent serotonin transporter	0	2	1	3
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Prostaglandin G/H synthase 2	0	4	0	6
Carbonic anhydrase	0	3	0	4
Alpha-1A adrenergic receptor	0	6	0	6
Carbonic anhydrase 7	0	2	0	3
Carbonic anhydrase	0	1	0	2
Histone deacetylase 4	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-3	10	2	0	12
Gamma-aminobutyric acid receptor subunit beta-2	10	2	1	13
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Prostaglandin G/H synthase 2	0	2	0	2
Histone deacetylase 1	0	2	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Carbonic anhydrase 9	0	4	0	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	6
Carbonic anhydrase	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
GABA theta subunit	10	2	0	12
Inositol hexakisphosphate kinase 1	12	0	0	12
Histone deacetylase 2	0	2	0	2
Carbonic anhydrase 4	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Carbonic anhydrase 15	0	3	0	4
Histone deacetylase 8	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	10	2	0	12
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Carbonic anhydrase 14	0	3	0	4
Histone deacetylase 5	0	2	0	2
Carbonic anhydrase 5B, mitochondrial	0	2	0	3
cytochrome P450 2C9, partial	12	0	0	12
Luciferase	10	0	0	10
15-lipoxygenase, partial	9	0	0	9
vitamin D3 receptor isoform VDRA	11	0	0	11
survival motor neuron protein isoform d	6	0	0	6
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Glutamine synthetase	0	1	0	1
Sex hormone-binding globulin	0	0	2	2
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
Fumarate hydratase	5	0	0	5
polyprotein	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
eyes absent homolog 2 isoform a	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
peripheral myelin protein 22 isoform 1	5	0	0	5
M-phase phosphoprotein 8	5	0	0	5
neuropeptide S receptor isoform A	5	0	0	5
Ghrelin O-acyltransferase	0	1	0	1
Monoglyceride lipase	0	1	0	1
14 kDa phosphohistidine phosphatase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
acid sphingomyelinase	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
Multidrug resistance-associated protein 1	0	0	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
D(1A) dopamine receptor	3	0	0	3
transcriptional regulator ERG isoform 3	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	1	2	4
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Albumin	0	2	3	5
Sodium-dependent dopamine transporter	0	3	0	3
Smoothened homolog	0	1	1	2
Glutamate receptor ionotropic, NMDA 2B	0	3	0	5
Sonic hedgehog protein	0	1	0	2
Sonic hedgehog protein	0	1	0	1
Smoothened homolog	0	2	2	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	5	0	5
Muscarinic acetylcholine receptor M1	0	5	0	5
Muscarinic acetylcholine receptor M3	0	5	0	5
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
nonstructural protein 1	8	0	0	8
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	2	2
Integrin beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	5
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	5
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	2	1	5
5-hydroxytryptamine receptor 2A	0	4	0	4
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	4	0	4
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	1	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	6	0	6
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 1D	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	3	2	5
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
D(3) dopamine receptor	0	4	1	7
Sodium channel protein type 1 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	4	0	4
Histamine H2 receptor	7	1	0	10
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	0	2
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	0	4
Glutamate receptor ionotropic, NMDA 2C	0	3	0	4
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	4
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	3	0	3
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	4
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	4
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
muscleblind-like protein 1 isoform 1	7	0	0	7
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Albumin	0	1	0	2
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	6
Caspase-1	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	3	0	3
Caspase-3	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	2	0	2
Caspase-5	0	2	0	2
Caspase-9	0	2	0	2
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	0	1	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	0	1	1
Prostacyclin receptor	0	2	1	3
Prostacyclin receptor	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Prostaglandin D2 receptor	0	0	1	1
histone deacetylase 9 isoform 3	3	0	0	3
BRCA1	1	0	0	1
SUMO-1-specific protease	0	1	0	1
SUMO1/sentrin specific peptidase 7	0	1	0	1
STAT3, partial	0	0	1	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
huntingtin isoform 2	5	0	0	5
caspase-3 isoform a preproprotein	0	2	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	0	1	1
sentrin-specific protease 8	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
cellular tumor antigen p53 isoform a	5	0	0	5
WRN	1	0	0	1
integrase, partial	0	2	0	2
lens epithelium-derived growth factor p75	0	2	0	2
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
Polyphenol oxidase 2	0	1	0	3
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Tyrosinase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	1	0	2
phosphoglycerate kinase	2	0	0	2
Neprilysin	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Atrial natriuretic peptide receptor 3	0	1	0	1
Thromboxane A2 receptor	0	1	0	2
Type-1A angiotensin II receptor	0	2	1	3
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	1	5
Type-1 angiotensin II receptor	0	1	1	2
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
Squalene synthase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Type-1 angiotensin II receptor	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	3	0	4
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
PINK1	2	0	0	2
Parkin	3	0	0	3
Estrogen receptor	0	4	1	5
Glucocorticoid receptor	0	10	4	19
Progesterone receptor	0	4	1	6
Glycine receptor subunit alpha-1	0	10	0	10
Mineralocorticoid receptor	0	3	1	4
Androgen receptor	0	5	0	5
Androgen receptor	0	0	1	1
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Aldo-keto reductase family 1 member C2	0	2	0	2
Guanine nucleotide-binding protein G	4	0	0	4
Aldo-keto reductase family 1 member C1	0	2	0	2
Estrogen receptor beta	0	4	1	5
Solute carrier family 22 member 2	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
protein AF-9 isoform a	0	0	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Amyloid-beta precursor protein	0	2	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Inositol monophosphatase 1	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
endonuclease IV	2	0	0	2
GALC protein	1	0	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
Estrogen receptor	0	1	0	1
Gastric inhibitory polypeptide receptor	0	1	0	1
Estrogen receptor beta	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Butyrophilin subfamily 3 member A1	0	0	2	3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Adenylate kinase isoenzyme 1	0	0	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Capsid protein	0	0	1	1
Reverse transcriptase/RNaseH	0	1	1	4
beta-2 adrenergic receptor	1	0	0	1
Beta-2 adrenergic receptor	0	0	2	2
Beta-1 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	3
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (409)

Protein Targets (954)

Bone Stress Reaction

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (409)

Drugs Studied (146)

Protein Targets (954)